Artykuły w czasopismach: „Premature rupture of fetal membranes”

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Sefik Gokce i Dilsad Herkiloglu. "Premature rupture of membranes". World Journal of Advanced Research and Reviews 11, nr 3 (30.09.2021): 363–70. http://dx.doi.org/10.30574/wjarr.2021.11.3.0393.

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Prenatal (premature) rupture of membranes (PROM) is defined as rupture of fetal membranes before the onset of labor or regular uterine contractions. PROM can lead to serious complications such as uterine cavity infection, umbilical cord compression, oligohydramnios, fetal malpresentation, umbilical cord prolapse, preterm delivery, fetal asphyxia and death. Initial evaluation of all term pregnancies with suspected PROM should include confirmation of membrane rupture and assessment of maternal and fetal well-being. Immediate initiation of labor is recommended in term pregnant women with PROM. Compared with expectant management, induction of labor is associated with a reduction in maternal and possibly neonatal infection and lower treatment costs without an increase in cesarean delivery. Induction with oxytocin is recommended. Oxytocin is as effective as prostaglandins, easier to titrate and may be less expensive depending on the preparation. Balloon catheter use is not recommended for cervical ripening in PROM.

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Azqinar, Tiara Cornela, i Agung Ikhssani. "The Role of Vitamin C in the Prevention of Premature Rupture of Membranes". Journal of Maternal and Child Health Sciences (JMCHS) 1, nr 2 (17.12.2021): 51–56. http://dx.doi.org/10.36086/maternalandchild.v1i2.966.

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Premature rupture of membranes [PROM] is an early event in approximately one third of preterm births resulting in significant infant mortality and morbidity. The exact mechanism by which the fetal membranes weaken and rupture in term and preterm pregnancy is unknown. However, it has been hypothesized that the fetal membranes weaken and eventually rupture as a result of collagen remodeling and apoptosis. Some studies have speculated that vitamin C supplementation during pregnancy will be useful in the prevention of PROM but some studies have also shown that vitamin C supplementation does not affect normal fetal membrane remodeling processes leading to weakening and rupture of the fetal membranes. This literature review discusses the role of Vitamin C in the prevention of PROM, where the role of vitamin C can induce collagen degradation and apoptosis. The assumption that vitamin C supplementation may be a prophylactic regimen for premature PROM should be investigated further. Caution should be exercised in using vitamin C supplements to prevent PROM in pregnant women. This literature review discusses the role of vitamin C in preventing premature rupture of membranes.

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Fitriyani, Fitriyani. "FAKTOR DETERMINAN PADA KETUBAN PECAH DINI". JURNAL MEDIA KESEHATAN 11, nr 1 (16.11.2018): 053–61. http://dx.doi.org/10.33088/jmk.v11i1.357.

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Every year the incidence of premature rupture of membranes ranges from 5-10% of all preterm preterm births and membranes occurring in 1% of all pregnancies.70% of cases of premature rupture of membranes occur in early pregnancy, prematurerupture of membranes is the cause of preterm birth as much as 30% (Manuaba, 2010). Atthe Derah Kepahiang General Hospital, the incidence of premature rupture of membranesis 219 cases in 2016.This research is analytical descriptive research with case controldesign. The sample in this study amounted to 138 people divided into two groups of 69cases and 69 controls. Statistical test using chi square test and binary logisticregression.Results of the study of 69 people with premature rupture of membranes atmaternal age <20 and> 35 years (46.4%), primiparity and grandemultipara parity(62.3%), fetal abnormalities (33.3%), gestational age aterm ( 63.8%) and those with ahistory of premature rupture (18.8%) in Kepahiang Hospital by 2016. Maternal age (pvalue0.013 OR = 2.646), parity (p-value 0.0,0 OR OR = 3.111) (p-value 0,0017 OR =2,950), gestational age (p-value 0,386) and history of premature rupture (p-value 0,167)at Kepahiang Hospital 2016. The most dominant factor causing premature rupture ofmembranes in RSUD Kepahiang year 2016 is parity (Exp (B) 2,806).It is expected thatthe hospital can use the research as input to suppress the incidence of premature ruptureof membranes, by counseling to explain the risk factors of premature rupture ofmembranes, especially maternal age, parity and fetal abnormalities.

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Banotra, Palvi, Zahoor Ahmad i Samaa Haneef. "Fetal-Maternal Complications due to Premature Rupture of Membranes: A Prospective Study at Valley’s Famous Maternity Hospital". International Journal of Research and Review 9, nr 1 (29.01.2022): 610–13. http://dx.doi.org/10.52403/ijrr.20220170.

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Background: The fetal membrane remains intact till the labor starts in order to maintain the protective intrauterine fluid environment. However, sometimes membranes ruptures prematurely (PROM), a condition in which the disruption of fetal membranes takes place before the beginning of labor that ultimately results in spontaneous leakage of amniotic fluid. The present study is aimed to evaluate the feto-maternal outcomes due to premature rupture of membranes at term. Methods: A total 70 pregnant women patients with premature rupture of membranes after 37 completed weeks were selected in the study after they properly signed the consent form. Gestational age was confirmed from LMP, clinically, and radiologically. Cervical dilatation of <3 cms, Lack of uterine contractions for at least 1 hour from PROM, Single live pregnancy in vertex presentation and PROM confirmed by Direct visualization or Litmus. Results: Febrile illness as maternal outcome was found in 18.6% patients followed by wound infection in 4.3%. Rest of the patients had pph (2.9%), UTI (1.4%) and sepsis (2.9) as maternal outcome. Perinatal outcome was assessed among the studied patients and it was found that (17.1%) had birth asphyxia followed by (5.7%) patients with septicemia perinatal outcome. Only (2.9%) patients had death as perinatal outcome. Conclusion: The present study revealed that PPROM is undoubtedly associated with a prenatal morbidity and mortality. However, early diagnosis and timely management is must in order to reduce the associated complications due to PROM. Keywords: Premature rupture of membrane, perinatal complications, gestational age.

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Parry, Samuel, i Jerome F. Strauss. "Premature Rupture of the Fetal Membranes". New England Journal of Medicine 338, nr 10 (5.03.1998): 663–70. http://dx.doi.org/10.1056/nejm199803053381006.

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Weitz, Beth W. "PREMATURE RUPTURE OF THE FETAL MEMBRANES". MCN, The American Journal of Maternal/Child Nursing 26, nr 2 (marzec 2001): 86–92. http://dx.doi.org/10.1097/00005721-200103000-00007.

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Draper, Deborah, Ward Jones, R. Phillip Heine, Michelle Beutz, Janice I. French i James A. McGregor. "Trichomonas vaginalisWeakens Human Amniochorion in an In Vitro Model of Premature Membrane Rupture". Infectious Diseases in Obstetrics and Gynecology 2, nr 6 (1995): 267–74. http://dx.doi.org/10.1155/s1064744995000160.

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Objective: Trichomonas vaginalis (TV)infection is associated with preterm rupture of membranes (PROM) and preterm birth. We evaluated the effects ofTVgrowth and metabolism on preparations of human amniochorion to understand and characterize howTVmay impair fetal-membrane integrity and predispose to PROM and preterm birth.Methods:Term fetal membranes were evaluated using an established in vitro fetal-membrane model. FreshTVclinical isolates were obtained from pregnant women. The protozoa (5.0×105to1.5×106/ml) were incubated with fetal membranes in modified Diamond's medium for 20 h at 37°C in 5%CO2.The effects of fetal-membrane strength (bursting tension, work to rupture, and elasticity) were measured using a calibrated Wheatstone-bridge dynamometer. Tests were also performed to evaluate the effects of 1) inoculum size; 2) metronidazole (50 μg/ml); and 3) cell-free filtrate.Results:TheTV-induced membrane effects were 1) isolate variable; 2) inoculum dependent; 3) incompletely protected by metronidazole; and 4) mediated by both live organisms as well as protozoan-free culture filtrates. Six of 9 isolates significantly reduced the calculated work to rupture (P≤ 0.02); 7 of 9 reduced bursting tension; and 1 of 9 reduced elasticity. One isolate significantly increased the work to rupture and bursting tension (P≤ 0.002).Conclusions:In vitro incubation of fetal membranes withTVcan significantly impair the measures of fetal-membrane strength. This model may be used to delineate the mechanisms ofTV-induced membrane damage. This study suggests that there are enzyme-specific effects as well as pH effects.

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Tkalich, V. O., V. V. Bila i O. S. Zahorodnya. "The prevalence of inflammatory process in placentas from premature births in different gestational periods". Reproductive health of woman, nr 5 (31.07.2024): 90–94. http://dx.doi.org/10.30841/2708-8731.5.2024.310399.

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Premature birth (PB) is the birth in less than 37 weeks, which can be spontaneous and iatrogenic, its frequency reaches 10% of all births. The pathogenesis of premature labor is based on the inflammatory reaction of the chorion, amnion and decidual membrane, but the origin of the inflammatory reaction is different depending on the gestational age.The objective: to study the prevalence of the inflammatory response in placenta samples from very early preterm, early preterm and term births.Materials and methods. Placenta samples from 203 parturient women who gave birth in the gestational period of 22–27 weeks – very early PB (I group – 101 parturient women with premature rupture of membranes (PROM), II group – 102 parturient women with the onset of labor with intact membranes) and 202 parturient women were examined with deliveries in the period of 28–34 weeks – early PB (III group – 100 women in labor with PROM and IV group – 102 women in labor with the onset of labor with intact fetal membranes) and 60 women in labor with term deliveries.Immunohistochemical detection of CD8, CD3 and CD14 antigens in villi was used to assess the prevalence of the inflammatory process and compare it between groups.Results. In 56.7% of placentas from term deliveries no markers of villousitis were detected, a mild form of villousitis was found in another third of cases. In placentas of woman with the onset of labor between the 28th and 34th weeks with intact fetal membranes there were signs of villousitis in 54.9%, and its mild manifestations in 33.3%. In the case of premature rupture of the membranes, the prevalence of villousitis reached 65%, its severe forms were more often observed.On the other hand, in the groups of very early PB only 14.9 and 15.7% of placentas had no signs of vilouisitis, one in five placentas from these groups had severe focal or diffuse villousitis. In the group of early PB and intact amniotic membranes, one third of the placentas demonstrated an isolated CD3 lymphocyte marker, no antigen was detected in 47.1% of placentas, and only in every tenth placenta antigens of macrophages of fetal origin were determined. A similar distribution was found in placentas from early PB with PROM.In placentas from very early PB the highest frequency of CD14 detection was found – every second placenta contained this marker in isolation and in 22.5% – in combination with maternal lymphocyte markers. In the group of very early PB on the background of PROM placentas with a positive CD14 test dominated – 31.7% isolated and 45.5% in combination with CD3.Conclusions. 1. In placentas from premature births (PB) at 28–34 weeks, villousitis was detected in 54.9% of cases against the background of intact amniotic membranes and in 65.0% – on the background of premature rupture of the membranes, from very early PBs – in 85.1% and 83.3%, respectively. Placentas from deliveries with premature rupture of the fetal membranes more often had signs of severe villousitis – in 21% of cases at 28–34 weeks and in 20.6% at 22–27 weeks.2. In placentas from early PB, macrophage antigen of fetal origin was detected in 22% of cases in the cases of premature rupture of the fetal membranes and in 21.6% of cases of childbirth with intact membranes; these samples were dominated by infiltration by lymphocytes of maternal origin. On the other hand, placentas from very early PB and ruptured fetal membranes in 77.2% of cases contained antigen of fetal macrophages and in 71.6% of cases of onset of labor with intact membranes.Such results indicate the fetal origin of the inflammatory process in very early PB.

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Ohel, Gonen, E. Sadovsky, Y. Aboulafia, A. Simon i G. Zajicek. "Fetal Activity in Premature Rupture of Membranes". American Journal of Perinatology 3, nr 04 (październik 1986): 337–38. http://dx.doi.org/10.1055/s-2007-999892.

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M., Poovathi, i Yogalaksmi Yogalaksmi. "A study of perinatal outcome in preterm premature rupture of membranes". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, nr 12 (26.11.2018): 5061. http://dx.doi.org/10.18203/2320-1770.ijrcog20184967.

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Background: Preterm premature rupture of membranes is defined as rupture of fetal membrane before onset of labour at less than 37 completed weeks of gestation and after 28 weeks of gestation. Incidence ranges from 3-10% of all deliveries. Preterm premature rupture of membrane is one of the important causes of preterm birth can result inhigh perinatal morbidity and mortality. Preterm premature rupture of membranes complicates 3% of pregnancies and leads to one third of preterm birth. Preterm delivery affects one in 10 birth in USA and even greater birth in developing continues and causes 40-75% neonatal death. There are numerous risk factors for preterm premature rupture of membrane such as maternal, socioeconomic class, infection at early gestational age and associated co-morbid condition. Both mother and fetus are at greater risk of infection after preterm premature rupture of membrane.The fetal and neonatal morbidity and mortality risks are significantly affected by severity of oligohydrominos, duration of latency and gestation at preterm premature rupture of membrane. The objective is to study perinatal outcome in preterm premature rupture of membrane.Methods: This is a prospective study conducted in Mahathma Gandhi Memorial Government Hospital attached to K. A. P. V. Government Medical College, Trichy, Tamil Nadu, India. This is a tertiary health centre. This study has been conducted from January 2018 to June 2018.Results: Incidence of PPROM ranges from 3.0-10.0% of all deliveries. PPROM complicates approximately 3% of pregnancies and leads to one third of preterm birth.Conclusions: In present study most of newborn had better 5min Apgar especially late preterm group. In present study RDS was common in early preterm group and hyper bilirubinaemia common in late preterm group. In current study most of patients delivered vaginally compared to 36% of LSCS.

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Afanasyeva, Marina H., Vyacheslav M. Bolotskih i Victoria O. Polyakova. "Signal molecules as biomarkers of prediction of the premature rupture of membranes (clinicodiagnostic aspects)". Journal of obstetrics and women's diseases 65, nr 6 (15.12.2016): 19–27. http://dx.doi.org/10.17816/jowd65619-27.

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One of the most commonly encountered pregnancy complications is the premature rupture of membranes. This pathology results in the increase of frequency of operative delivery, birth traumatism and neonatal complications. The purpose of the research described was verification of key signal molecules, providing integrity of fetal membranes, with subsequent development of possible biomarkers of non-invasive prediction of the premature rupture of membranes. This work presents the comparison studies of expression of VEGF, MMP-9, connexin 37, connexin 40, endorphins, enkephalins, actin, miosin in a buccal epithelium and fetal membranes for 70 patients of the basic group (with premature rupture of membranes) and for 70 patients of the control group (with timely rupture of membranes). Research of fetal membranes and buccal epithelium was carried out by means of primary monoclonal mouse antibodies to the investigated markers. The universal basis set was used as the secondary antibodies, containing of biotinylated anti-mouse immunoproteins. The study of the preparations was carried out in the confocal microscope OLYMPUS FLUOVIEW FV 1000 at the image enlargement of ×400 and ×1000 with use of the system MRC-1024, with the software suite for computer processing OLYMPUS FLUOVIEW 5.0. Statistical processing of the material was carried out with the application of the standard statistical software suite Statistica 10.0. Obtained in a group with the premature rupture of membranes and in a control group were the reliable differences of expression of MMP-9, VEGF, connexin 37 and connexin 40 were. The multifactorial analysis of the indices of expression of signal molecules allowed to discover the high information significance for premature rupture of membranes prediction, matrix metalloproteinase ММP-9, connexin 37 and connexin 40, as well as VEGF. Matrix metalloproteinase ММP-9, connexin 37 and connexin 40, VEGF can be considered as non-invasive markers of premature rupture of membranes prediction.

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Rahayu, Budi, i Ayu Novita Sari. "Studi Deskriptif Penyebab Kejadian Ketuban Pecah Dini (KPD) pada Ibu Bersalin". Jurnal Ners dan Kebidanan Indonesia 5, nr 2 (7.11.2017): 134. http://dx.doi.org/10.21927/jnki.2017.5(2).134-138.

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Premature Rupture Membranes is a rupture of the membranes prematurely. KPD Cause not known with certainty, but nothing to do with uterine hypermotility, thin membranes, infections, multiparous, maternal age, location of the fetus, and previous history of premature rupture of membranes. Impact of the KPD can cause maternal or neonatal infection, hypoxia or compression of the umbilical cord, fetal deformity syndrome, increased Caesarean labour or normal delivery failure, and increased morbidity and maternal perinatal mortality. This study was to identify the cause of the incident picture premature rupture in women giving birth in hospitals in Yogyakarta. This study uses descriptive design quantitative used retrospective time approach. The population in this study are all mothers who have premature rupture of membranes in hospitals in Yogyakarta in obtained from medical records. Premature rupture of membrane in Yogyakarta Hospital there are 427 cases. A sampling technique that with a total sampling with 427 respondents. Analysis of the data used univariate analysis. The results that most respondents are multipara many as 245 people (57.4%), aged 20-35 years as many as 265 people (62.1%), gestational age ≥37 weeks as many as 343 people (80.3%), over distensi uteri as many as 410 people (96.1%), where the fetus head presentation many as 396 people (92.7). In conclusion, an overview of the causes of premature rupture events on maternal includes multipara, 20-35 years of age, gestational age ≥37 weeks, normal uterine enlargement, and the location of the fetus normal presentation.

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Safa, D. Jilan Haura, Adib Ahmad Shammakh, Dany Karmila i Irwan Setyobudi. "The Relationship of Mother's Age, Parity, and Abnormalities in Fetal Location with The Incidence of Premature Ruptur of Membranes in The Regional Public Hospital of North Lombok". Jurnal Biologi Tropis 24, nr 1b (23.12.2024): 575–83. https://doi.org/10.29303/jbt.v24i1b.8252.

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Premature rupture of membranes (PROM) is one of the main causes of the high newborn mortality rates and maternal mortality rate (MMR), which continue to be significant global health challenges. The purpose of this study is to examine the association between the occurrence of PROM at the North Lombok Regional Public Hospital and maternal age, parity, and fetal anomalies. This research uses a case-control study design and is an analytical observational study. Purposive sampling was utilized to choose the research sample, which included 186 people in total. The chi-square test was used to analyze the data and determine how the variables related to one another. According to the study's findings, 120 (64.5%) respondents were not at risk, while 66 (35.5%) were. Of the respondents, 131 (70.4%) had parity without risk, while 55 (29.5%) had parity at risk. Respondents with fetal abnormalities were 28 (15.1%) and 158 (84.9%) had normal fetuses. Age and the frequency of premature membrane rupture are related; the p-value is 0.022 and the OR is 2.145. With a p-value of 0.024 and an OR of 2,203, there is a correlation between parity and the frequency of premature membrane rupture. Premature rupture of the membranes and fetal abnormalities do not correlate, as indicated by the p-value of 0.538. The incidence of PROM is correlated with maternal age and parity, although there is no significant link between PROM and fetal abnormalities.

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Lestariningsih, Yanu Yufita. "Hubungan Ketuban Pecah dengan Kejadian Asfiksia Neonatorum di RSUD Kabupaten Kediri Tahun 2016". Jurnal Kebidanan Midwiferia 3, nr 2 (2.10.2017): 19. http://dx.doi.org/10.21070/mid.v3i2.1467.

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Premature rupture of membranerevolves 5-10% from all birth. Impact a birth premature that espoused broken fetal membrane early causess 12-15% asphyxia neonatorum. The purpose of the study to determine the correlation between premature rupture of membrane with the incidence of asphyxia neonatorum. The research method used is analytic with retrospective cohort approach with independent variable of premature rupture of membrane, dependent variable asphyxia neonatorum. The study was conducted on 7 June to 12 July 2017. The population of 1519 mothers inregional public hospital of Kediri regency 2016. Sample 139 respondents, taken by simple random sampling, was analyzed by Chi Square test with a significant of 0.05. Result of research most of respondent with rupture of membrane counted 46 respondents, almost all respondents that is 82.6% gave birth baby with asphyxia. From result of Chi Square test obtained by result of p-value equal to 0.000 (<0.05), result of coefficient of contingency (C) equal to 0.639 with closeness strong relation, so H1 received H0 rejected which means there is significant relation with closeness strong between premature rupture of membrane with asphyxia neonatorum inregional public hospital of Kediri regency 2016. Relative Risk (RR) 1.65 which means the possibility of a baby experiencing asphyxia neonatorum of 1.65 times in maternal who experience premature rupture of membranes compared to mothers who did not experience premature rupture of membranes.

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Widia, Nani, Yulizar Yulizar i Merisa Riski. "Faktor-Faktor yang Berhubungan dengan Terjadinya Ketuban Pecah Dini (KPD) di Rumah Sakit Muhammadiyah Palembang Tahun 2021". Jurnal Ilmiah Universitas Batanghari Jambi 22, nr 2 (26.07.2022): 817. http://dx.doi.org/10.33087/jiubj.v22i2.1914.

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WHO said cases of premature rupture of membranes ± 5-10% of the total births. PROM in preterm cases is 1% and term pregnancies are 22% of the total pregnancies. Premature rupture of membranes is the rupture of the membranes before the time of delivery that occurs at the end of pregnancy or before. Factors causing PROM are divided into general factors, heredity factors, and obstetric factors. This study aims to determine the relationship between fetal position abnormalities, multiple pregnancies, parity and infection with premature rupture of membranes at Palembang Muhammadiyah Hospital in 2021. Analytical survey research with a Cross Sectional approach. All mothers giving birth at term who were treated at the Palembang Muhammadiyah Hospital in January-May 2021, totaling 965 were used as the population and a sample of 91 mothers were taken using simple random sampling technique. The primary data used was then analyzed by univariate and bivariate analysis by chi square test. The results showed that there was a relationship between fetal position abnormalities (Pvalue = 0.031), multiple pregnancy (Pvalue = 0.001), parity (Pvalue = 0.031) and infection (Pvalue = 0.018) with premature rupture of membranes at Muhammadiyah Hospital Palembang in 2021. It is expected from the results of the study. This can be an illustration for the hospital to further improve health services, especially dealing with the incidence of premature rupture of membranes.

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Dyatlova, L. I., i T. N. Glukhova. "Role of altered amniotic fluid cytokine profile in in development of fetal membrane insufficiency". Medical Immunology (Russia) 26, nr 2 (15.11.2023): 389–92. http://dx.doi.org/10.15789/1563-0625-tro-2880.

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Studies on pathogenesis of fetal membrane insufficiency in preterm pregnancy should expand the opportunities of predicting prenatal rupture of amniotic fluid and improve the strategy of anticipant gestation management in cases of premature rupture of the fetal membranes. The clinical significance of studying this obstetric problem is unquestionable due to the high risk of complications and perinatal losses caused by preterm birth. This research is devoted to studying the changes in cytokine profile of amniotic fluid during prenatal rupture of amniotic fluid at 22 to 34 weeks of gestation. The levels of pro-inflammatory (TNFα, IL-6, IL-1β, IL-2, IL-6, IL-8) and anti-inflammatory (IL-4, IL-10) cytokines in amniotic fluid were determined in 30 patients, whose premature pregnancy was complicated by early rupture of the membranes. For reference, the level of these cytokines in the amniotic fluid was studied in 25 pregnant women with a physiological course of pregnancy at full-term gestation. The ELISA technique was used with a test system produced by JSC Vector-Best. The study was carried out on the basis of the Perinatal Center of the Saratov Region. We have found that premature rupture of the membranes is preceded by increased levels of pro-inflammatory cytokines in amniotic fluid. The latter result suggests a significant alteration in feto-placental complex, which may be the starting point both for damage to the fetal membranes, as well as for development of labor activity.

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Sulastri, Sulastri, i Meri Epriana Epriana. "Analisis Faktor Resiko Ketuban Pecah Dini Di Rsud Mukomuko Kabupaten Mukomuko Tahun 2021". JMNS 3, nr 2 (11.02.2022): 19–34. http://dx.doi.org/10.57170/jmns.v3i2.68.

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Premature rupture of membranes is very dangerous for pregnant women and their babies, the danger of premature rupture of membranes is infection occurs in mother and baby. The rupture of the membranes leaves the baby unprotected by the amniotic membrane and exposed to contact with the outside world, which causes bacteria to enter the mother's womb and infect both mother and baby. This can be life-threatening for both mother and baby. In addition, the birth of a baby that is less than the normal time causes premature babies and the risk of fetal defects is high. The purpose of this study was to analyze the risk factors for premature rupture of membranes in Mukomuko Hospital, Mukomuko Regency. The method used is descriptive-analytical research design using a case-control design. The population in this study were all mothers who gave birth at the Mukomuko Hospital, the sample in this study amounted to 100 people with a ratio of case and control groups of 1:1. Case samples (cases) were taken by total sampling, namely (50 mothers who gave birth with PROM), while the control sample was taken by random sampling from the entire population who did not experience premature rupture of membranes. Bivariate statistical test using Chi-square (X²). The results of univariate analysis most of the respondents (74.0%) were not infected, most of the respondents (71.0%) did not do pregnancy exercise, most of the respondents (54.0%) were primiparous, most of the respondents (82.0%) had no history of premature rupture of membranes, some respondents (50.0%) experienced premature rupture of membranes and some respondents (50.0%) did not experience premature rupture of membranes. The results of the bivariate analysis showed that there was a relationship between infection, pregnancy exercise, parity, and a history of PROM with the incidence of premature rupture of membranes. It is hoped that the hospital must have socialization of pregnancy exercise and the dangers of KPD in pregnant women.

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Khan, Maira, i Saima Khattak. "Comparison of induction of labor versus conservative management in premature rupture of membranes on fetal outcome". Anaesthesia, Pain & Intensive Care 28, nr 3 (30.05.2024): 541–46. http://dx.doi.org/10.35975/apic.v28i3.2470.

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Background & Objective: Premature rupture of the membranes (PROM) is defined as rupture of the membranes (amniotic sac) before the commencement of the labor and after 37 weeks gestation. Opinions differ whether to induce labor in these parturients or continue to manage conservatively. The purpose of this research was to compare the incidence of unfavorable fetal outcomes in cases of early rupture of the membranes and expectant treatment in the induction of labor. Methodology: This randomized controlled trial was conducted at the Department of Obstetrics & Gynaecology, Lady Reading Hospital, Peshawar, from 1st August 2022 to 31st January 2023. A total of 610 pregnant women with PROM were included in the study. In total, 305 patients were in the expectant management group or Group A, while 305 patients were in induction of labor or Group B. After delivery, fetal outcomes (birth asphyxia, low Apgar score, and sepsis) were noted and compared in both groups. Results: Birth Asphyxia was observed in 69 (22.6%) patients in Group A as compared to 44 (14.4%) patients in Group B (P = 0.009). A low Apgar Score was observed in 27 (8.9%) patients in Group A compared to 10 (3.3%) patients in Group B (P = 0.004). Sepsis was observed in 8 (2.6%) patients in Group A as compared to 1 (0.3%) patient in Group B (P = 0.019). Conclusion: It is concluded that all patients presenting with premature rupture of membranes at term should be actively managed with induction of labor. Keywords: Pregnancy; Premature rupture of membranes; Labor induction; Expectant management; Adverse fetal outcomes Citation: Khan M, Khattak S. Comparison of induction of labor versus conservative management in premature rupture of membranes on fetal outcome. Anaesth. pain intensive care 2024;28(3):541−546; DOI: 10.35975/apic.v28i3.2470 Received: March 08, 2024; Reviewed: May 01, 2024; Accepted: May 05, 2024

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ALLEN, STEVEN R. "Epidemiology of Premature Rupture of the Fetal Membranes". Clinical Obstetrics and Gynecology 34, nr 4 (grudzień 1991): 685–93. http://dx.doi.org/10.1097/00003081-199112000-00004.

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Jakobovits, Ákos A., i László Zubek. "Premature rupture of the membranes and fetal sex". American Journal of Obstetrics and Gynecology 159, nr 5 (listopad 1988): 1307–8. http://dx.doi.org/10.1016/0002-9378(88)90473-5.

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Magsi, Shahida, Sonia Gul Qureshi, Fatima Rajput, Basma Zia i Inayatullah Magsi. "Frequency of Cesarean Section in Premature Rupture of Membranes". Pakistan Journal of Medical and Health Sciences 16, nr 8 (31.08.2022): 74–76. http://dx.doi.org/10.53350/pjmhs2216874.

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Background: Premature rupture of membranes (PROM) is always of clinical significance either it occurs before onset of labour at term or preterm. It is defined as spontaneous rupture of fetal membranes which results in leakage of amniotic fluid. PROM is related with maternal and perinatal morbidity and mortality if not treated sensibly on time, due not only to conditions causing it but also likelihood of emergency cesarean delivery. Aim: To ascertain frequency of C- section in women presented with premature rupture of membranes at tertiary care hospital. Study Design: Cross-sectional descriptive study Place and Duration of Study: Department of Obstetrics and Gynaecology Unit 1, Sheikh Zayed Women Hospital, Shaheed Mohtarma Benazir Bhutto Medical University Larkana from 1st October 2020 to 30th April 2021 Methodology: One hundred and eighty six pregnant women having gestation from 28 weeks till 40 weeks and diagnosed as premature rupture of membranes were included. Results: The average age 27.97±5.66 years. 29.57% of caesarean section presented PROM was observed. Conclusion: PROM remains an imperative cause of maternal and fetal morbidity and increased rate of cesarean section delivery to focus upon. Timely evaluation of reasons leading to PROM can help us in reducing the soaring rate of cesarean section in developing countries. Keywords: Premature rupture of membranes, Caesarean section, complications.

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Muliani, Resty Himma. "ANALISIS FAKTOR RESIKO KETUBAN PECAH DINI DI PUSKESMAS MARGADANA". Jurnal Ilmiah Kebidanan Imelda 10, nr 1 (30.03.2024): 1–4. http://dx.doi.org/10.52943/jikebi.v10i1.1555.

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Maternal Mortality Rate is an indicator of maternal welfare that occurs from pregnancy to the end of the postpartum period. Infection is one of the contributors to AKI in Indonesia. Premature rupture of membranes is a condition where the membranes rupture before the time of delivery which occurs at the end of pregnancy or prematurely which can cause infection. This research is a descriptive study with the research objective to determine the risk factors for KPD in the Margadana Health Center area of Tegal City. The total population is 22 respondents. The research results showed that the majority of respondents who experienced premature rupture of membranes were multiparous and aged 20 to 35 years. There were more respondents with normal fetal position than abnormal position and most respondents did not experience pre-eclampsia.

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ZOYA, S. NAZ, SB SOOMRO, ZAINAB, PARAS i N. KHOKHAR. "FETAL OUTCOME OF PREGNANCY WITH PRETERM PREMATURE RAPTURE OF MEMBRANE AT SHAIKH ZAID WOMEN HOSPITAL, LARKANA SINDH". Biological and Clinical Sciences Research Journal 2024, nr 1 (24.12.2024): 1380. https://doi.org/10.54112/bcsrj.v2024i1.1380.

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Preterm premature rupture of membranes (PPROM) is a multifactorial condition that can significantly influence fetal outcomes, primarily through complications linked to preterm birth and increased vulnerability to infections Objective: The main objective of the study is to find the fetal outcome of pregnancy with the preterm premature rupture of membrane at Shaikh Zaid Women Hospital, Larkana Sindh Methods: This research utilises descriptive cross-sectional fetal outcomes In pregnancies complicated by preterm premature rupture of membranes (PPROM). The study is conducted in the Department of Obstetrics and Gynecology at Shaikh Zaid Women’s Hospital in Larkana, Sindh from 1st September 2023 to 28 February 2024. The sample size calculation is based on previous studies, particularly considering early fetal death as a sensitive outcome, with an incidence rate of 14.3%. Results: Data were collected from 74 patients and the mean age of participants was 30.98 years (± 5.12), with an average BMI of 27.5 kg/m² (± 4.3), reflecting a moderately high weight profile among the cohort. Most participants (60%) were multigravidas, while 40% were experiencing their first pregnancy (primigravidas). Additionally, 65% of the participants belonged to a lower socioeconomic status, which may have influenced their access to prenatal care and associated pregnancy outcomes. A prior history of PPROM was noted in 20% of cases, while 25% of participants had a urinary tract infection, and 18% had a vaginal infection, both of which are known risk factors. Smoking was reported by 10% of the mothers, and a majority (65%) belonged to a lower socioeconomic status. Conclusion: It is concluded that preterm premature rupture of membranes (PPROM) significantly impacts neonatal outcomes, increasing the risks of complications such as low birth weight, respiratory distress, and infections.

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Bila, V. V. "Laboratory manifestations of fetal inflammatory response syndrome in extremely premature newborns". REPRODUCTIVE ENDOCRINOLOGY, nr 73 (18.10.2024): 68–73. https://doi.org/10.18370/2309-4117.2024.73.68-73.

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Background. Fetal inflammatory response syndrome (FIRS) is a pathological response to changes in the chorion and is manifested by inadequate cytokine production and endothelial dysfunction.Objective of the study: to investigate laboratory changes in extremely premature newborns depending on the presence of FIRS criteria. Materials and methods. The prevalence of umbilical cord blood leukocytosis and leukopenia, anemia and thrombocytopenia, as well as increased levels of C-reactive protein and procalcitonin in 403 premature newborns was analyzed depending on the presence of FIRS laboratory criteria. Newborns were divided depending on the gestational age (I and II groups – 24–27 weeks, III and IV groups – 28–34 weeks), and the presence of prenatal rupture of the fetal membranes (I and III groups) or the onset of labor with intact membranes (II and IV groups). Results. FIRS increases the frequency of leukopenia, anemia, and thrombocytopenia in extremely premature newborns, and the frequency of leukocytosis and the appearance of young forms of leukocytes in premature infants from early preterm labour. Elevated levels of C-reactive protein and procalcitonin were more common in cases of premature rupture of membranes than in cases of labor with intact amniotic sac. This frequency did not depend on the presence of FIRS in extremely premature newborns; such dependence was outlined for premature infants from early preterm labour. Conclusions. Leukopenia is more often found in premature babies from very early premature births than from early premature births. More than 20 × 109/ml leukocytosis and an increased proportion of young forms of neutrophils of more than 10% were found in the case of premature rupture of the fetal membranes, more often than during childbirth with intact membranes. In extremely premature newborns FIRS was accompanied by an increased frequency of leukopenia, thrombocytopenia, and anemia. FIRS do not increase levels of C-reactive protein and procalcitonin in extremely premature newborns.

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KHVOROSTUKHINA, NATALIA F., VLADISLAV O. BAKHMACH, OKSANA V. TRUSHINA, EKATERINA A. KOLESNIKOVA, OKSANA S. ODNOKOZOVA i RUSLAN V. CHUPAKHIN. "PREMATURE RUPTURE OF MEMBRANES IN FULL-TERM PREGNANCIES AS A RISK FACTOR OF UTERINE CERVIX RUPTURES IN CHILDBIRTH". Bulletin of Contemporary Clinical Medicine 17, nr 1 (luty 2024): 63–70. http://dx.doi.org/10.20969/vskm.2024.17(1).63-70.

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Abstract. Introduction. Premature rupture of membranes continues to be one of the urgent problems in modern obstetrics, since it is exactly the pathology a high frequency of unfavorable pregnancy outcomes is associated with. At the same time, an equally important task in obstetrics and gynecology remains the problem of maternal birth injuries, including cervical ruptures, the frequency of which ranges 6 to 15 %. Aim. To study how premature ruptures of membranes in full-term pregnancies aﬀect the frequency of cervical ruptures in childbirth and to identify the risk factors of cervical injuries in at-term labor complicated by premature rupture of membranes. Materials and Methods. A retrospective analysis of birth histories for the years 2019-2020 was carried out according to the data of the perinatal center at Saratov City Clinical Hospital No. 8. The study group included 894 histories of single at-term vaginal deliveries complicated by premature rupture of membranes, while the control group included 6,735 birth histories of women whose vaginal deliveries were performed with timely ruptures of membranes. Later, we identiﬁed subgroups within the study group: Subgroup 1 (n=101) included patients with premature rupture of membranes at full-term gestation, whose at-term labors were complicated by uterine cervix ruptures, while Subgroup 2 (n=336) included women with premature ruptures of membranes during at-term labors without any maternal birth traumas. When analyzing medical records, special attention was paid to the anamnesis details and to the special aspects of birth courses and outcomes. Statistical data processing was performed using the MS Excel and Statistica 7.0 software programs. Diﬀerences in indications were considered statistically signiﬁcant at p<0.05. Results and Discussion. Probability of premature ruptures of membranes during full-term pregnancy increases in patients expecting their ﬁrst childbirth by 1.6 times (χ2 = 173.49; p <0.001), those with a burdened obstetric/gynecological history, such as abortions, miscarriages, and genital pathology, and those with concomitant extragenital diseases (85.9%). In the study group, we identiﬁed an increase in the incidence of labor anomalies (by 3 times) and acute fetal distress (by 1.9 times), which increased the proportion of using surgical aids in childbirth (by 2.7 times) and the risk of obstetric injuries to the mother (by up to 63.4%), including uterine cervix ruptures by up to 11.3%. Conclusions. Premature rupture of membranes at full-term gestation increases the risk of uterine cervix ruptures in childbirth by 10.3 times. In this obstetric context, the uterine cervix rupture risk factors should include the ﬁrst birth (57.4%; p= 0.003) in the absence of biological readiness of the birth canal (“unripe” or “insuﬃciently ripe” uterine cervix, 76.2%), development of ineﬀective uterine contractions (12.9%), and the use of surgical aids in delivery (vacuum-assisted deliveries and episiotomies, 32.7%).

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Tri Harjati, Eny Sendra, Lumastari Ajeng Wijayanti i Ririn Indriani. "Correlation between the Duration of Premature Rupture of Membranes during the Labor and the Asphyxia of Newborn Babies at Aura Syifa Hospital Kediri Regency". STRADA Jurnal Ilmiah Kesehatan 11, nr 2 (30.11.2022): 133–40. http://dx.doi.org/10.30994/sjik.v11i2.965.

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Premature Rupture of Membranes (PROM) is rupture of membranes more than one hour before onset of labor. One of the complications caused by PROM is asphyxia. The longer the rupture of the membranes the greater the risk of fetal distress. By the rupture of the membranes the amniotic fluid volume decreases and there is an emphasis on the umbilical cord so that there is less supply of oxygen and nutrients to the fetus which causes the newborn to have asphyxia.The purpose of this study was to determine the correlation between the length of premature rupture of membranes during labor with asphyxia of the new born infant in Aura Syifa Kediri Hospital. This study used an observational research design with a Cross Sectional approach.

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Aziz, Abdul, Siti Farida i Byba Melda Suhita. "Analysis of Factors that Influence the Occuration of Early Rapture of Money in Particular Patients in Pragaan Public Health Center, Sumenep Regency". Journal for Quality in Public Health 5, nr 1 (9.11.2021): 7–18. http://dx.doi.org/10.30994/jqph.v5i1.242.

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Pregnancy is a moment that is highly desired by husband and wife. This can make the family more harmonious because it has a child who is always coveted. But in reality, sometimes pregnancy is accompanied by several obstacles, such as premature rupture of membranes. The purpose of this study is to analyzethe effect of economic status, fetal position and family support on the incidence of premature rupture of membranes in inpartu patients at the Pragaan Health Center, Sumenep Regency. The design of this research is an observational quantitative research with a cross sectional approach with the focus of the research being directed at analyzingthe effect of economic status, fetal position and family support on the incidence of premature rupture of membranes in inpartu patients at the Pragaan Health Center, Sumenep Regency. The total population of 160 respondents and a sample of 100 respondents were taken by Accidental Sampling technique. The findings show that almost half of the respondents haveeconomic status middle class category as many as 42 respondents (42%).Almost half of the respondents experienced an anterior fetal position as many as 39 respondents (39%). Most of the respondents have family support in the less category as many as 62 respondents (62%). Most of the respondents experienced premature rupture of membranes as many as 56 respondents (56%). Based on the results of the Logistics Regression analysis shows that the p-value <0.05 then H1 is accepted so it is concluded that there is an effect of economic status, fetal position and family support for the incidence of premature rupture of membranes in inpartu patients at the Pragaan Health Center, Sumenep Regency. It is hoped that both pregnant women can manage the needs and things that must be done during pregnancy until delivery, starting from maintaining a lifestyle and even monitoring the development of the fetus in order to reduce the incidence of KTD.

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Baisova, Baisova A. R., Amiraslanov E. Yu Amiraslanov, Frankevich V. E. Frankevich, Chagovets V. V. Chagovets V, Tokareva A. O. Tokareva, Kulikova G. V. Kulikova, Shchegolev A. I. Shchegolev, Каn N. E. Каn i Tyutyunnik V. L. Tyutyunnik. "Lipid profile of fetal membrane tissue in premature rupture of membranes". Akusherstvo i ginekologiia 2_2025 (28.02.2025): 40–51. https://doi.org/10.18565/aig.2025.37.

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Timokhina, Elena V., Vladimir A. Lebedev, Alina M. Karpova, Parvin F. Kurbanzade i Mariya V. Mikheeva. "Premature rupture of the fetal membranes during premature pregnancy. Management: reality and prospects". V.F.Snegirev Archives of Obstetrics and Gynecology 8, nr 2 (1.06.2021): 93–100. http://dx.doi.org/10.17816/2313-8726-2021-8-2-93-100.

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Premature rupture of the fetal membranes is a complication of pregnancy, causing premature labour and birth of a premature newborn. Premature birth rate consist of 6 to 12%. MATERIALS AND METHODS: We perform a retrospective analysis of 71 cases of patients with a premature rupture of the fetal membranes with active and expectant management and perinatal outcomes. The 1st group consisted of 19 patients with a gestation age of 2228 weeks, the 2nd group ― 52 patients with a gestation age of 2934 weeks. RESULTS: The duration of the period between rupture of membranes and delivery in patients of the first group (2228 weeks) was: up to 48 hours ― 3 patients, 48 hours 14 days ― 15 patients, more than 14 days ― 1 patient. In patients of the second group (2934 weeks), respectively: up to 48 hours ―17 patients, 48 hours 14 days ― 30 patients, more than 14 days ― 5 patients. The duration of expectant management for PRFM in premature pregnancy is determined by the duration of pregnancy, the condition of the mother of the fetus, the presence of clinical and laboratory signs of chorioamnionitis, the amount and changing of the volume of amniotic fluid. The management of prolongation preterm pregnancy led to the fact that the gestational age at the time of delivery compared to the time of hospitalization significantly increased. In the group of patients, 2228 weeks gestation, the increase averaged 6.7 days, the maximum increase was 25 days, in the group of patients 2934 weeks gestation, the increase averaged 6.8 days, the maximum increase in gestational age was 35 days. CONCLUSION: The expectant management of premature pregnancy in PRFM allows to increase the gestational age (by an average of 6.8 days), to increase the weight of the fetus, to reduce perinatal mortality, to reduce the need for prematures in mechanical ventilation by more than half, to ensure a high level of discharge of newborns home.

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Lestari, Dwi Anggun. "Faktor Yang Mempengaruhi Kejadian Ketuban Pecah Dini Pada Kehamilan Trimester III di Puskesmas Silo Kabupaten Jember." MEDICAL JURNAL OF AL QODIRI 5, nr 1 (28.02.2020): 1–6. http://dx.doi.org/10.52264/jurnal_stikesalqodiri.v5i1.31.

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Premature rupture of membranes is rupture of membranes in pregnant women before any sign of labor. The direct cause of maternal death in Indonesia is 27% due to premature rupture of membranes which can ultimately lead to complications in puerperium. Based on the 2017 Riskesdas data, the Maternal Mortality Rate was 348 per 100,000 live births in 2015. In 2018 Jember district has a higher maternal mortality rate than the province. In 2018 at the Silo Health Center in Jember District, there were 239 cases of premature rupture of membranes in pregnant women. The purpose of this study was to study and explain the description of the incidence of premature rupture of membranes in pregnant women. The research design used is case control through a retrospective approach. The population in this study were 275 third trimester pregnant women with 153 mothers experiencing premature rupture of membranes and 122 who did not experience premature rupture of membranes. The sample size in this study was 122 cases and 122 controls. The control sample was taken by simple random sampling. Data collection was performed using medical records. The analysis of this study used univariate, bivariate using Chi Square (X²) and multivariate with Simple Logistic Regression test. In this study, the variables that influence the occurrence of premature rupture of membranes are age, occupation, parity, multiple pregnancy, fetal abnormalities, birth spacing and history of KPD with p value <0.05. The most dominant variable on the occurrence of premature rupture of membranes is the history of KPD with OR = 40.137: 95% CI and p value 0.000 so that different proportions of cases and controls are significant in the sense that there is a significant influence between the history of KPD on the incidence of premature rupture of membranes. So it is expected for third trimester pregnant women to be more diligent in doing ANC (Antenatal Care) in the next pregnancy.

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Sadia Ali Khan, Fatima Imran i Junaid Ali Khan. "Review of Feto-Maternal Outcome in Patients with Premature Rupture of Membranes at Term". Journal of Saidu Medical College, Swat 14, nr 2 (21.04.2024): 105–8. http://dx.doi.org/10.52206/jsmc.2024.14.2.855.

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Background: Premature rupture of membranes complicates 5 to 10 % of the singleton pregnancies and is a major contributor of maternal morbidity and neonatal morbidity and mortality in terms of sepsis and prematurity, even in the today's era of antibiotics. Most of these complications can be prevented provided timely, targeted management is initiated.Objectives: To provide a comprehensive understanding of the fetal and maternal outcome with premature rupture of membranes at term, for a better management.Material and Methods: This descriptive Cross Sectional study was conducted in department of Obstetrics and Gynecology HMC, from 15th of September 2022 till 15th of February 2023. Random sampling method was adopted in this study and a total of 241 patients presented with spontaneous rupture of membranes after 37 weeks till 41 weeks. A detail history, physical and gynecological examination was performed, and all the information gathered from the patient by the doctors was then recorded on a pre-designed proforma.Results: Out of 241 patients of PROM 60 cases of maternal and 145 cases of fetal complications were observed. As per maternal outcomes, 28(46.7%) patients had wound infection,16(26.6%) patients developed oligohydramnios, 07 (11.7%) patients were recorded with Puerperal Pyrexia secondary to endometritis, and 09 (15%) patients developed chorio-amnionitis. About 56% of the mothers had cesearen deliveries. As per fetal outcomes, 78(53.8%) cases were recorded with RDS, 35(24.1) with hyperbilirubinemia, 23 (16%) babies developed neonatal sepsis, and 09(6.2%) had necrotizing Enterocolitis. Conclusion: Premature Rupture of Membrane at term has a risk of both fetal and maternal complications. Prolonging pregnancy as in conservative management adds to the fetal and maternal morbidity more in terms of sepsis. In this study, we concluded that conservative management to prolong pregnancy carry risk both for mother and baby and is recommended only under strict monitoring.Keywords: Chorioamnionitis, Latency period, Maternal outcome, Perinatal outcome, Sepsis.

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Turlina, Lilin, Faizatul Ummah i Sulistyowati. "Risk Factors for Premature Rupture of the Membranes". Jurnal Kebidanan Midwiferia 6, nr 2 (16.12.2020): 35–43. http://dx.doi.org/10.21070/midwiferia.v6i2.605.

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The incidence of premature rupture of membranes (PRM) ranges from 8-10% at term pregnancy and 1% in preterm pregnancy. The incidence of PRM at RSUD dr. SoegiriLamongan in 2017 amounted to 16,43%. The purpose of this study was to analyze risk factors of the occurrence of premature rupture membranes in RSUD Dr. SoegiriLamongan. The research used descriptive analytical method with cross sectional approach. The sample is 268 maternity mothers, divided into 134 mothers giving birth with PRM and 134 normal maternity mothers at Dr. Soegiri Lamongan on 2018. Sampling is done by simple random sampling. Data collection uses patient medical record and with multivariate multiple logistic regression analysis.The results showed that presentation abnormalities with a p value of 0.045 <0.05 and CPD with a p value of 0.002 <0.05. Based on the Odds Ratio (OR) values as follows: Maternal age OR 1,141, OR parity 0.933, OR fetal presentation 2,779, OR Twins 1,394, OR CPD 6. and OR Large infants 0.783.Meaning that there was a significant influence between fetal presentation and CPD on PRM.

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Bila, V. V. "Fetal inflammatory response syndrome in extremely premature newborns". REPRODUCTIVE ENDOCRINOLOGY, nr 72 (30.06.2024): 53–59. https://doi.org/10.18370/2309-4117.2024.72.53-59.

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Background. Fetal inflammatory response syndrome (FIRS) is a pathological reaction of the fetal immune system to infection of the amnion or inflammation of the chorion, which significantly increases the risk of neonatal mortality and morbidity. Objective of the study: to study the clinical features of the course of the neonatal period in premature babies with different gestational periods against the background of FIRS. Material and methods. The course of the neonatal period was analyzed in 405 premature newborns, divided depending on the gestational age and the presence of premature rupture of the fetal membranes. The content of IL-6 in umbilical cord blood was determined in all newborns by enzyme-linked immunosorbent assay. Its value greater than 11 pg/ml was the basis for establishing a diagnosis of FIRS. The duration of respiratory support in general, artificial lung ventilation, non-invasive lung ventilation, and the need for additional oxygen, periventricular hemorrhages, and necrotizing enterocolitis were analyzed in all newborns depending on the presence of FIRS. Results. Extremely premature newborns with FIRS have a longer duration of both invasive and non-invasive ventilation, newborns from early preterm births with FIRS required non-invasive ventilation longer only in case of premature rupture of the fetal membranes. In extremely premature newborns with FIRS the duration of the additional oxygen supply increases, in newborns from early premature births this pattern was only in the case of premature rupture of the fetal membranes. Only in premature babies from very early premature births with FIRS a doubling of the frequency of hemorrhages in the ventricles of the brain and necrotizing enterocolitis was found. Conclusions. FIRS in extremely premature newborns is associated with a longer duration of invasive and non-invasive ventilation, as well as with a longer need for oxygen enrichment of inhaled air. FIRS in extremely premature newborns increase the frequency and severity of intraventricular hemorrhages and necrotizing enterocolitis.

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Albab, Muhamad Ulil, Heriyanti Widyaningsih, Sri Hartini i Ambarwati Ambarwati. "Incidence of Neonatal Asphyxia Events In Mothers Maternity With Early Ruptured Amniotic Fluid". South East Asia Nursing Research 2, nr 3 (30.09.2020): 99. http://dx.doi.org/10.26714/seanr.2.3.2020.99-104.

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Asphyxia and Intrauterine fetal dead (IUFD) are a threat if a premature rupture of membranes is not immediately treated quickly and appropriately. Neonatal asphyxia can occur due to complications from premature rupture of membranes. IMR in Indonesia is the fifth country for ASEAN countries, 35/1000 birth. Based on data from RA Kartini Hospital in Jepara, asphyxia cases from approximately (12,6%) and incidence of premature rupture of membranes 816 cases or around (85,8%). While the incidence of neonatal asphyxia born from PROM totalled 15 cases or about (1,6%). This research using quantitative descriptive methods with cross-sectional design. This research was conducted on April 21-23, 2020 using a total sampling method of 148 respondents. The data used are secondary data with a single variable, namely the incidence of neonatal asphyxia in mothers with maternity premature rupture of membranes. Data analysis uses a descriptive statical test. Aims to know the description of the incidence of neonatal asphyxia in mothers with maternity premature rupture of membranes in General Hospital of Raden Ajeng Kartini Jepara 2019 and describe the incidence of neonatal asphyxia in mothers with maternity premature rupture of membranes in General Hospital Raden Ajeng Kartini Jepara 2019. The result showed that of 148 respondents on average had no risk age (20-35 years) as many as 120 respondents (81,1%) and the average parity PROM mothers as many as 148 respondents had multiparous parity of 85 respondents (57,4%). Then from 148 PROM mothers, 6 respondents (4,1%) gave birth to babies who had asphyxia. The highest incidence of neonatal asphyxia in mothers with maternity premature rupture of membranes was mild asphyxia of 3 respondents (2,0%), moderate to severe asphyxia of 2 respondents (1,4) and moderate asphyxia of 1 respondent (0,7%). The average degree of asphyxia in women with premature rupture of membranes is mild asphyxia.

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Rufaida, Zulfa. "Proporsi Asfiksia Neonatorum pada Kasus KPD dengan Non KPD di RSUD dr. Mohammad Soewandhi Surabaya". Jurnal Kebidanan Midwiferia 2, nr 1 (30.04.2016): 34–44. http://dx.doi.org/10.21070/mid.v2i1.762.

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Severe fetal or asphyxia intrauterin can be a result of cord compression and repetitive due to prolonged reduction prolapsus amniotic fluid or umbilical cord. Complications are most common in PROM before 37 weeks gestation is respiratory distress syndrome (asphyxia), which occurs in 10-40% of new born babies. Risk of infection, disability, and death was also increased in the PROM events. This research methods, analytical case control study design. Inpartu mother population in maternity hospitals VK dr. Mohamad Soewandhie Surabaya in 2008 some 2101 cases. Sampling techniques proportional stratified random sampling. Large sample of 67 cases. Independent variable, premature rupture of membranes (PROM) and the dependent variable, neonates asphyxia. Instruments used data collection sheets. Sources of data from medical records. Analysis of data using non-parametric statistical approach Chi Square. The results of 33 cases of maternal inpartu that experience premature rupture of membranes (PROM), had 20.9% asphyxia and from were 34 cases of inpartu mothers who did not KPP, 20.9% experienced not asphyxia. Chi Square test results, X2arhitetic <X2table (1.802 <3.48) means that there is no difference in incidence neonates asphyxia in premature rupture cases (KPP) and no premature rupture of membranes (non – KPP). The conclusion of this study, less than 50% of inpartu mothers who experienced premature rupture of membranes (PROM), and more than 50% occurred asphyxia was, and there was no difference in incidence neonates asphyxia in premature rupture cases (KPP) and no premature rupture of membranes (non – KPP).

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Zhong, Nanbert. "Extracellular Matrix in Preterm Premature Rupture of Fetal Membranes". American Journal of Biomedical Science & Research 13, nr 1 (1.06.2021): 54–60. http://dx.doi.org/10.34297/ajbsr.2021.13.001831.

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Al-Zaid, N. S., K. A. Gumaa, M. N. Bou-Resli, M. E. A. Ibrahim i N. S. Al-Zaid. "Premature Rupture of Fetal Membranes Changes in Collagen Type". Acta Obstetricia et Gynecologica Scandinavica 67, nr 4 (styczeń 1988): 291–95. http://dx.doi.org/10.3109/00016348809004222.

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Romero, R., J. Espinoza, LF Gonçalves, R. Gomez, L. Medina, M. Silva, T. Chaiworapongsa i in. "Fetal cardiac dysfunction in preterm premature rupture of membranes". Journal of Maternal-Fetal & Neonatal Medicine 16, nr 3 (1.09.2004): 146–57. http://dx.doi.org/10.1080/jmf.16.3.146.157.

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VINTZILEOS, ANTHONY M., i ROBERT A. KNUPPEL. "Fetal Biophysical Assessment in Premature Rupture of the Membranes". Clinical Obstetrics and Gynecology 38, nr 1 (marzec 1995): 45–58. http://dx.doi.org/10.1097/00003081-199503000-00007.

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Al-Zaid, N. S., K. A. Gumaa, M. N. Bou-Resli i M. E. A. Ibrahim. "Premature Rupture of Fetal Membranes Changes in Collagen Type". Acta Obstetricia et Gynecologica Scandinavica 67, nr 4 (styczeń 1988): 291. http://dx.doi.org/10.1111/j.1600-0412.1988.tb07801.x.

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R, Romero, Espinoza J, Gonçalves LF, Gomez R, Medina L, Silva M, Chaiworapongsa T i in. "Fetal cardiac dysfunction in preterm premature rupture of membranes". Journal of Maternal-Fetal and Neonatal Medicine 16, nr 3 (1.09.2004): 146–57. http://dx.doi.org/10.1080/14767050400009279.

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Goldstein, Israel, Joshua A. Copel i John C. Hobbins. "Fetal Behavior in Preterm Premature Rupture of the Membranes". Clinics in Perinatology 16, nr 3 (wrzesień 1989): 735–54. http://dx.doi.org/10.1016/s0095-5108(18)30629-8.

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Meira, A. B. C., H. Cattini, D. Meira, D. Roucourt i S. Roucourt. "Fetal complications related to premature rupture of the membranes". International Journal of Gynecology & Obstetrics 70 (2000): B122. http://dx.doi.org/10.1016/s0020-7292(00)83080-5.

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Roberts, Alistair B., Israel Goldstein, Roberto Romero i John G. Hobbins. "Fetal breathing movements after preterm premature rupture of membranes". American Journal of Obstetrics and Gynecology 164, nr 3 (marzec 1991): 821–25. http://dx.doi.org/10.1016/0002-9378(91)90523-t.

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Khade, Shweta Avinash, i Amarjeet Kaur Bava. "Preterm premature rupture of membranes: maternal and perinatal outcome". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, nr 11 (25.10.2018): 4499. http://dx.doi.org/10.18203/2320-1770.ijrcog20184496.

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Background: This is an observational analytical study carried out in department of obstetrics and Gynecology, in a tertiary care center to determine the factors influencing fetal and maternal outcome, prognosis and complications in preterm premature rupture of membrane cases.Methods: The present study is a prospective observational study of perinatal and maternal outcome in 100 cases of preterm premature rupture of membranes in between 2837 weeks gestation with singleton pregnancy, from 1st March 2013 to 28th February 2014. Patients with medical complications like anemia, preexisting hypertension, diabetes, vascular or renal disease, multiple gestations, uterine or fetal anomalies etc. are excluded from the study. Detailed history, physical examinations were carried out and appropriate management instituted as per individual patients need.Results: In this study maternal morbidity was 16%. Perinatal morbidity was 33% and most common causes were hyperbilirubinemia (23%), RDS (21%). Perinatal mortality was seen in 15% and mainly due to RDS (53%). Twenty-five (25%) neonates were delivered by cesarean. The main indications for cesarean being malpresentation (36%) followed by fetal distress (24%).Conclusions: PPROM is one of the important causes of preterm birth that can result in high perinatal morbidity and mortality along with maternal morbidity. Looking after a premature infant puts immense burden on the family, economy and health care resources of the country. An understanding of gestational age dependent neonatal morbidity and mortality is important in determining the potential benefits of conservative management of preterm PROM at any gestation.

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Desi Hariani. "1035325 Hubungan Kadar Hemoglobin Ibu dan Letak Janin dengan Kejadian Ketuban Pecah Dini di Klinik Alisa Talang Kramat Kenten Tahun 2018". Jurnal Kebidanan : Jurnal Medical Science Ilmu Kesehatan Akademi Kebidanan Budi Mulia Palembang 9, nr 1 (1.06.2019): 26–31. http://dx.doi.org/10.35325/kebidanan.v9i1.162.

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ABSTRAK Ketuban pecah dini adalah pecahnya selaput ketuban pada setiap saat sebelum permulaan persalinan tanpa memandang apakah pecahnya selaput ketuban terjadi pada kehamilan 24 minggu atau 44 minggu. Kadar hemoglobin adalah ukuran pigmen respiratorik dalam butiran-butiran darah merah. Kelainan letak janin merupakan malpresentasi janin atau kelainan letak janin yang dapat membuat ketuban bagian terendah langsung menerima tekanan intra uteri yang dominan. Tujuan penelitian ini adalah mengetahui hubungan kadar hemoglobin ibu dan letak janin dengan kejadian ketuban pecah dini di klinik alisa talang keramat kenten Palembang Tahun 2018. Desain penelitian ini menggunakan metode survey analitik dengan pendekatan crossectional. Sampel berjumlah 63 orang. Pengambilan menggunakan teknik total sampling. Pengumpulan data menggunakan lembar checklist.Hasil analisis univariat didapatkan jumlah ibu yang mengalami ketuban pecah dini (22,3%), HB tidak normal (41,3%) dan letak sungsang (6,3%). Dari hasil analisis bivariat dengan uji statistik Chi – Square ada hubungan bermakna antara kadar hemoglobin ibu p value = 0,001 < α 0,05 nilai OR = 0,049 dan letak janin p value = 0,001 < α 0,05 nilai OR = 0,032 dengan kejadian ketuban pecah dini secara statistik terbukti. Melalui penelitian ini, diharapkan dapat memberikan pelayanan kesehatan yang lebih baik lagi pada ibu hamil dan bersalin sehingga tidak terjadi komplikasi. Kata Kunci : Ketuban Pecah Dini, Kadar Hemoglobin, Letak Janin ABSTRACT Premature rupture of membranes isthe rupture of the membranes at any time before the onset of labor, regardless of whether the rupture of the membranes occurs at 24 weeks or 44 weeks' gestation. Hemoglobin levels are the size of respiratory pigments in red blood granules. Fetal abnormalities are malpresentations of fetuses or fetal abnormalities that can make the lowest part of the membrane directly accept the dominant intrauterine pressure. The aim of this study is to know the correlation between maternal hemoglobin level and fetal location toward the incidence of premature rupture of membranes at klinik alisa talang keramat kenten The study design using analytical survey method with crossectional approach. The sample numbered 63 people. Taking by using total sampling technique. Data collection using checklist sheet. The result of univariate analysis showed that the number of mothers who had membranes rupturedearly was (22.3%), HB was not normal (41.3%) and breech position was (6.3%). From bivariate analysis with Chi-Square statistical test there was a significant correlation between maternal hemoglobin level p value = 0.001 <α 0.05 value OR = 0.049 and fetal location p value = 0.001 <α 0.05 value OR = 0.032 with incidence of premature rupture of membranes was statistically proven. Through this research, it is expected to provide better health services in pregnant and maternity women so thereis no complications occur. Key word : Premature rupture of membranes, Hemoglobin levels, Fetal Location

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Jatav, Deepika, i Nootan Chandwaskar. "ASSESSMENT OF FACTORS INCREASING THE RISK OF PRELABOUR RUPTURE OF MEMBRANES AND ITS EFFECT ON FETOMATERNAL OUTCOME". International Journal of Advanced Research 11, nr 07 (31.07.2023): 963–71. http://dx.doi.org/10.21474/ijar01/17305.

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Background: Premature rupture of membranes (PROM) refers to a patient who is beyond 37 weeks gestation and has presented with rupture of membranes (ROM) prior to the onset of labor. Patient with PROM presents with leakage of fluid, vaginal discharge and pelvic pressure, but they are not having contraction. It occurs in 3 percent of pregnancies and is the cause of approximately one third of preterm deliveries. It can lead to significant perinatal morbidity, including respiratory distress syndrome, neonatal sepsis, umbilical cord prolapse, placental abruption, and fetal death. Appropriate evaluation and management are important for improving neonatal outcomes. The risk of intrauterine infection increases with the duration of ROM. Evidence supports the idea that induction of labor, as opposed to expectant management, decreases the risk of chorioamnionitis without increasing the cesarean delivery rate. Methods: - This present observational study was conducted at Obstetrics & Gynecology, Department at Sri Aurobindo Medical College and Post Graduate Institute, Indore and who satisfy the inclusion criteria will be studied from 1st April 2021 to 30th September 2022 (18 months). After were Institutional ethical committee. among the patients diagnosed as premature rupture of membrane with women complain of leaking attending antenatal OPD and antenatal ward. On admission detailed history was taken. General and Systemic examination were done including Per Abdomen, Per Speculum and per vaginum carried out and investigations were done as per protocol. Diagnosis of PROM was confirmed by any of this method. Continuous monitoring of maternal and fetal condition done, antibiotics was given intra/ post natal period. P/ V exam were done when necessary. Investigations done and maternal and fetal outcome were noted. Results: The prevalence of premature rupture of membranes (PROM) was found to be 4.1%, with a corresponding perinatal mortality rate of 0.18 per 1000 deliveries. Approximately 33% of the cases involved pre-term premature rupture of membranes (PROM), while the remaining 67% were term PROM. Among the cases with preterm PROM, 10% of the perinatal deaths occurred. The average age of the female participants was 36.9 years, with a standard deviation of 2.1 years. The median number of children per participant was 1, with a range of 1 to 5 children. A notable correlation was observed between the gestational age at which premature rupture of membranes (PROM) occurred in women and the latency period (p< 0.001). There was a significant association between the gestational age at which premature rupture of membranes (PROM) occurred and foetal birth weight, APGAR score, and Neonatal Intensive Care Unit (NICU) admission (p<0.05). A statistically significant distinction was observed between the implemented intervention and the method of delivery (p=0.009). Conclusion: The incidence of PROM at term was high and conservative/ expectant management was effective. The latency period and fetal outcomes such as birth weight, apgar score and NICU admission were determined by the gestational age at which PROM occurred.

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Mandrykova, A. S. "Morphological features of the state of fetoplacental complex in women with early preterm birth after assisted reproductive technologies". HEALTH OF WOMAN, nr 8(114) (30.10.2016): 79–81. http://dx.doi.org/10.15574/hw.2016.114.79.

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The objective: the study of morphofunctional changes of the fetoplacental complex at 28–33 weeks of gestation in women with early preterm delivery after the application of ART. Patients and methods. We have examined 130 patients whose pregnancy occurred after the use of ART. This is the woman who gave birth at 28–33 weeks of gestation. Of these, 80 women had early premature births in the background premature rupture of fetal membranes, 50 – patients with early preterm delivery and timely rupture of fetal membranes (control group 2). The main group included 4 groups of 20 women with regard to the duration of anhydrous interval: 1.1 – anhydrous interval 5–6 hours (main group 1); 1.2 – anhydrous span 24 hours; 1.3 – anhydrous interval 45–48 hours; 1.4 – anhydrous period 5 days after PRFM. Results. Thus, the results of the research indicate that the main cause of early preterm birth in women after using ART are structural dezorhanization changes of collagen fibers of the connective tissue amnion and chorionic which lead to the appearance of microscopic defects – delamination its surface, causing premature rupture of fetal membranes the launch stage localized focal immediate type hypersensitivity reactions and restructuring epithelial cell membranes. Neutrophil macrophage properties in this case reduced and programmed to perform a cycle of incomplete phagocytosis, which increases the synthesis of inflammatory cytokines in the area of rupture of fetal membranes. Сonclusion. Reduced activity of neutrophils increases the effect of abuse and cytokine balance in favor predictor of early spontaneous labor at 28-33 weeks of gestation. Key words: morphological changes of the fetoplacental complex, early preterm birth, expectant tactics of childbirth.

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Nahar, Nurun, Nadira Haque, nahreen Akhtar, Tabinda Anjum Aziz, Rajshree Debnath, Khadija Khan Toma i Afsana Raushan. "Maternal and Fetal Outcome in Term Premature Rupture of Membrane". Dinajpur Medical College Journal 18, nr 01 (1.01.2025): 25–30. https://doi.org/10.69861/djmcj2025v18i1s5.

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Abstract Background: Premature rupture of membranes (PROM) is a significant obstetric desperation.PROMrefers to the breakingof fetal membranes before the onset of labor, resulting in spontaneous leakage of amniotic fluid. PROM, which occurs before 37 weeks of gestation is defined as preterm PROM and PROM that occurs after 37 weeks of gestation is defined as term PROM. It is associated with detrimental maternal and perinatal consequence. Method: This cross-sectional observational study was carried out in the Department of Obstetrics & Gynecology, Bangabandhu Sheikh Mujib Medical University between 1st March 2017 and 31st August 2017. The aim of the study was to assess the maternal and fetal outcome in term premature rupture of membrane and to address the preventable cause for better outcome. A total of 60 pregnant women having term premature rupture of membranes admitted at Department of Obstetrics &Gynecology were enrolled for the study. Statistical analysis of the results was performed by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-20). Results: This study shows greater number of the patients (41.7%) were between the age group of 26-30 years. Among them maximum was multigravida (61.7%) and 60% of term PROM cases have association with medical comorbidities and infections (18.3% anemia, 13.3% UTI, 15% HTN with DM and 6.7% DM). Maximum patients with term pregnancy with PROM went in to spontaneous labor and delivered. Puerperal sepsis was the most frequent maternal morbidity (38.3%) and 10% developed chorioamnionitis. Perinatal outcome:53.3% had birth weight >2.5 kg and 46.7% had birth weight ≤2.5 kg .And 20% had Apgar score<7, 13.3% had developed neonatal jaundice and 10% neonates had developed septicemia. Conclusion: Puerperal sepsis was the most common maternal complication of term PROM and neonatal jaundice and septicemia were more common fetal outcome.

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Mayang Sari, Dwi Saputri. "HUBUNGAN KEHAMILAN GANDA DAN KELAINAN LETAK JANIN DENGAN KEJADIAN KETUBAN PECAH DINI DI RUMAH SAKIT UMUM DAERAH KOTA PRABUMULIH TAHUN 2019". Jurnal Kesehatan Abdurrahman 9, nr 2 (25.09.2020): 56–63. http://dx.doi.org/10.55045/jkab.v9i2.114.

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Early rupture of membranes (KPD) is defined as premature rupture of membranes. This can occur late in pregnancy or long before the time of delivery. Premature rupture of membranes is a complication associated with gestational pregnancy and has a major contribution to the perinatal mortality rate in infants who are preterm. The purpose of this study was to determine the relationship between multiple pregnancy and fetal abnormalities with the occurrence of premature rupture of membranes in the Prehumulih City General Hospital in 2019.This study uses an Analytical Survey using a Cross Sectional approach. The population of this study was mothers who gave birth in the pre-Sumatran city general hospital in 2019 totaling 1712 people. The number of samples in this study were 324 respondents. In the univariate analysis, it is known that of 324 respondents found that mothers who were diagnosed with multiple pregnancy were 163 respondents (50.3%) while mothers who were not diagnosed with multiple pregnancy were 161 respondents (49.7%) and mothers who were diagnosed with fetal abnormalities were 163 respondents ( 50.3%) while mothers who were not diagnosed with fetal abnormalities were 161 respondents (49.7%). Bivariate analysis shows multiple pregnancy has a significant relationship with the incidence of premature rupture of membranes (p value 0,000) and fetal abnormalities have a significant relationship with the incidence of premature rupture of membranes (p value 0,000). The conclusion of this study is that there is a relationship between multiple pregnancy and abnormalities in fetal location and the incidence of premature rupture of membranes in the Prehumulih City General Hospital in 2019. Ketuban Pecah Dini (KPD) didefinisikan sebagai pecahnya ketuban sebelum waktunya melahirkan. Hal ini dapat terjadi pada akhir kehamilan maupun jauh sebelum waktunya melahirkan. Ketuban pecah dini merupakan komplikasi yang berhubungan dengan kehamilan kurang bulan dan mempunyai kontribusi yang besar pada angka kematian perinatal pada bayi yang kurang bulan. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kehamilan ganda dan kelainan letak janin dengan kejadian ketuban pecah dini di rumah sakit umum daerah kota prabumulih tahun 2019. Penelitian ini menggunakan Survey Analitik dengan menggunakan pendekatan Cross Sectional. Populasi penelitian ini adalah ibu yang melahirkan di rumah sakit umum daerah kota prabumulih tahun 2019 berjumlah 1712 orang. Jumlah sampel pada penelitian ini adalah 324 responden. Pada analisa univariat diketahui bahwa dari 324 responden didapatkan ibu yang didagnosa kehamilan ganda sebanyak 163 responden (50,3%) sedangkan ibu yang tidak didiagnosa kehamilan ganda sebanyak 161 responden (49,7%) dan ibu yang didagnosa kelainan letak janin sebanyak 163 responden (50,3%) sedangkan ibu yang tidak didiagnosa kelainan letak janin sebanyak 161 responden (49,7%). Analisa Bivariat menunjukkan kehamilan ganda mempunyai hubungan yang bermakna dengan kejadian ketuban pecah dini (p value 0,000) dan kelainan letak janin mempunyai hubungan yang bermakna dengan kejadian ketuban pecah dini (p value 0,000). Simpulan dari penelitian ini adalah bahwa ada hubungan antara kehamilan ganda dan kelainan letak janin dengan kejadian ketuban pecah dini di rumah sakit umum daerah kota prabumulih tahun 2019.

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