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Artykuły w czasopismach na temat „Primary intracranial fibrous histiocytomas”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Martha, Lilia Tena-Suck, Sánchez-Garibay Carlos, and Salinas-Lara Citlaltepelt. "Intracranial Pleomorphic Malignant Fibrous Histiocytoma, Associated to Systemic Lupus Erythematous: A Case Report." British Journal of Medicine & Medical Research 21, no. 9 (2017): 1–9. https://doi.org/10.9734/BJMMR/2017/32743.

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<strong>Background:</strong> Pleomorphic Malignant Fibrous histiocytoma (MFH) is a rare neoplasms of the soft tissue and bone composed of fibroblastic and histiocytic components with mitosis figures, nuclear pleomorphism and anaplasia. <strong>Case Presentation:</strong> We presented a rare case of MFH in 44 year old woman with history of systemic erythematosus lupus and seizures. Treated with prednisone. The cerebral TAC showed a temporal mass. Craniotomy was performed and the examination of the biopsy sample revealed a giant, pleomorphic and atypical cells. Immunohistochemical analysis showe

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Koşucu, Polat, Ali Aydın Yavuz, Melek Nur Yavuz, Abdülkadir Reis, and Ali Ahmetoğlu. "Primary intracranial malignant fibrous histiocytoma." European Journal of Radiology Extra 47, no. 2 (2003): 78–81. http://dx.doi.org/10.1016/s1571-4675(03)00091-9.

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Ochalski, Pawel G., James T. Edinger, Michael B. Horowitz, et al. "Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage." Journal of Neurosurgery 112, no. 5 (2010): 978–82. http://dx.doi.org/10.3171/2009.8.jns081518.

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Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults. The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis. To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease). This is the second report of primary intracranial AFH. Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biol

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4

Deb, Prabal, Vikram Singh, Vibha Dutta, HS Bhatoe, and VijaiMohan Chandran. "Primary intracranial benign fibrous histiocytoma: Report of an unusual case." Journal of Cancer Research and Therapeutics 10, no. 1 (2014): 200. http://dx.doi.org/10.4103/0973-1482.131417.

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Ideguchi, Makoto, Koji Kajiwara, Koichi Yoshikawa, et al. "Benign fibrous histiocytoma of the skull with increased intracranial pressure caused by cerebral venous sinus occlusion." Journal of Neurosurgery 111, no. 3 (2009): 504–8. http://dx.doi.org/10.3171/2008.11.jns081206.

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The authors present a very rare case of benign fibrous histiocytoma of the skull with increased intracranial pressure caused by sinus occlusion. A 33-year-old woman was referred for investigation of a right occipital protrusion with tenderness and double vision. She had only mild divergence insufficiency and bilateral papilledema neurologically. Imaging findings showed that the skull tumor was located at the right occipital bone with bone disruption and a compressed right sigmoid sinus. When planning the resection, caution was required to spare the collateral flow so as to manage the intracran

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6

Bin Abdulqader, Sarah, Khalid Altuhaini, Raghad Tallab, et al. "Primary Intracranial Angiomatoid Fibrous Histiocytoma: Two Case Reports and Literature Review." World Neurosurgery 143 (November 2020): 398–404. http://dx.doi.org/10.1016/j.wneu.2020.07.225.

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Mazur-Hart, David J., Brannan E. O'Neill, Brandi W. Pang, et al. "Operative Technique: Angiomatoid Fibrous Histiocytoma—Unique Case and Management." Journal of Neurological Surgery Reports 83, no. 03 (2022): e110-e118. http://dx.doi.org/10.1055/s-0042-1754320.

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Abstract Objective We describe the first jugular foramen angiomatoid fibrous histiocytoma (AFH) case and the first treatment with preoperative endovascular embolization. AFH is a rare intracranial neoplasm, primarily found in pediatric patient extremities. With an increase in AFH awareness and a well-described genetic profile, intracranial prevalence has also subsequently increased. Study Design We compare this case to previously reported cases using PubMed/Medline literature search, which was performed using the algorithm [“intracranial” AND “angiomatoid fibrous histiocytoma”] through Decembe

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8

Berry, Allen D., Stephen L. Reintjes, and John J. Kepes. "Intracranial malignant fibrous histiocytoma with abscess-like tumor necrosis." Journal of Neurosurgery 69, no. 5 (1988): 780–84. http://dx.doi.org/10.3171/jns.1988.69.5.0780.

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✓ A case of a malignant fibrous histiocytoma (MFH) in the right temporal lobe of a 75-year-old man is reported. The tumor involved the brain and the overlying dura as one continuous mass and had undergone extensive liquefaction necrosis of its center that had a gross appearance similar to that of an abscess. The preoperative computerized tomography scan with injection of contrast material showed the lesion to have central and peripheral enhancement suggestive of metastatic tumor, glioblastoma multiforme, or abscess. Microscopically, the tumor showed the typical features of a MFH with marked ac

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9

Hansen, Jakob Møller, Vibeke Andrée Larsen, David Scheie, Arie Perry, and Jane Skjøth-Rasmussen. "Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features." Cephalalgia 35, no. 14 (2015): 1334–36. http://dx.doi.org/10.1177/0333102415583988.

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A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia. Three years later, changes in her headache pattern prompted hospital referral. Brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions. The resection specimen yielded a rare diagnosis of primary intracranial angiomatoid fibrous histiocytoma (AFH). Tumor removal resulted in cessation of her migraine and anemia. AFH may cause systemic symptoms – in this case fatigue and anemia – long before focal neurological symptoms are present. This is the first repo

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10

Maruno, Motohiko, A. K. M. Ghulam Muhammad, Junji Taguchi, et al. "Giant cell type of primary intracranial malignant fibrous histiocytoma: a case report." Brain Tumor Pathology 23, no. 1 (2006): 65–70. http://dx.doi.org/10.1007/s10014-006-0200-2.

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11

Sion, Amanda E., Rizwan A. Tahir, Abir Mukherjee, and Jack P. Rock. "Cranial angiomatoid fibrous histiocytoma: A case report and review of literature." Surgical Neurology International 11 (September 18, 2020): 295. http://dx.doi.org/10.25259/sni_282_2020.

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Background: Angiomatoid fibrous histiocytoma (AFH) is a rare low-grade soft-tissue tumor that typically arises from the deep dermal and subcutaneous tissue of the extremities in children and young adults. Intracranial AFH is exceedingly rare, and only four cases of primary AFH tumors have been reported to date. Case Description: A 43-year-old male presented to our hospital with headaches, vision changes, and a known brain tumor suspected to be an atypical meningioma. After undergoing craniotomy for resection of the mass, the immunomorphologic features of the resected tumor showed typical featu

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12

Pople, Ian K., and Brian Harding. "Primary intracranial malignant fibrous histiocytoma in a 5-year-old boy: Case report." British Journal of Neurosurgery 5, no. 5 (1991): 509–13. http://dx.doi.org/10.3109/02688699108998481.

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13

Özhan, S., E. T. Tali, S. Işik, M. R. Saygili, and K. Baykaner. "Haematoma-like primary intracranial malignant fibrous histiocytoma in a 5-year-old girl." Neuroradiology 41, no. 7 (1999): 523–25. http://dx.doi.org/10.1007/s002340050797.

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14

Peng, Li, Zhou Qiangyi, Yang Zhijun, et al. "Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review." Translational Neuroscience and Clinics 2, no. 3 (2016): 155. http://dx.doi.org/10.18679/cn11-6030/r.2016.024.

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15

Li, Peng, Qiangyi Zhou, Zhijun Yang, et al. "Clinical Features and Prognostic Factors of Primary Intracranial Malignant Fibrous Histiocytoma: A Report of 8 Cases and a Literature Review." Translational Neuroscience and Clinics 2, no. 3 (2016): 155–64. http://dx.doi.org/10.18679/cn11-6030_r.2016.024.

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16

Moliterno, Jennifer A., Shreya Sood, Eduardo Zambrano, Jung H. Kim, Joseph M. Piepmeier, and Joachim M. Baehring. "Intracranial benign fibrous histiocytomas: a case report and review." Journal of Neuro-Oncology 92, no. 2 (2008): 203–9. http://dx.doi.org/10.1007/s11060-008-9743-x.

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17

Curry, William T., Garth Rees Cosgrove, Fred H. Hochberg, Jay Loeffler, and Nicholas T. Zervas. "Stereotactic interstitial radiosurgery for cerebral metastases." Journal of Neurosurgery 103, no. 4 (2005): 630–35. http://dx.doi.org/10.3171/jns.2005.103.4.0630.

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Object. The Photon Radiosurgery System (PRS) is a miniature x-ray generator that can stereotactically irradiate intracranial tumors by using low-energy photons. Treatment with the PRS typically occurs in conjunction with stereotactic biopsy, thereby providing diagnosis and treatment in one procedure. The authors review the treatment of patients with brain metastases with the aid of the PRS and discuss the indications, advantages, and limitations of this technique. Methods. Clinical characteristics, treatment parameters, neuroimaging-confirmed outcome, and survival were reviewed in all patients

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18

Sima, A. A. F., R. T. Ross, G. Hoag, B. Rozdilsky, and M. Diocee. "Malignant Intracranial Fibrous Histiocytomas. Histologic, Ultrastructural and Immunohistochemical Studies of Two Cases." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 13, no. 2 (1986): 138–45. http://dx.doi.org/10.1017/s0317167100036088.

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ABSTRACT:Two cases of malignant intracranial fibrous histiocytoma are presented. In Case 1 the tumour arose from the meninges and showed a disseminated spread throughout the neuroaxis. In the second case the tumour appeared to arise from within the brain substance. In this case surgical intervention and radiotherapy appeared to have achieved a cure, since no residual tumour was found at autopsy.The tumours were examined using ultrastructural and immunohistochemical techniques, which appeared advantageous in delineating this rare tumour from other intracranial neoplasms.

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19

Altunkol, Adem, Murat Savas, Halil Ciftci, Mehmet Gulum, Ismail Yagmur, and Muharrem Bitiren. "Primary giant cell malignant fibrous histiocytoma-associated with renal calculus." Canadian Urological Association Journal 8, no. 3-4 (2014): 193. http://dx.doi.org/10.5489/cuaj.1485.

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Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics.

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20

Johnson, Sarah, Malte Renz, Lindsay Wheeler, et al. "Vulvar sarcoma outcomes by histologic subtype: a Surveillance, Epidemiology, and End Results (SEER) database review." International Journal of Gynecologic Cancer 30, no. 8 (2020): 1118–23. http://dx.doi.org/10.1136/ijgc-2020-001516.

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ObjectiveVulvar cancers account for 5% of all gynecologic malignancies; only 1%–3% of those vulvar cancers are primary vulvar sarcomas. Given the rarity of vulvar sarcomas, outcome data specific to histopathologic subtypes are sparse. The aim of this study was to identify clinical and pathologic factors of primary vulvar sarcomas that are associated with survival and may inform treatment decisions.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was searched for women diagnosed with vulvar sarcoma between 1973 and 2018. We identified 315 patients and reviewed their demogr

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21

Domingo, Ricardo A., Tito Vivas-Buitrago, Mark Jentoft, and Alfredo Quinones-Hinojosa. "Intracranial Myxoid Mesenchymal Tumor/Myxoid Subtype Angiomatous Fibrous Histiocytoma: Diagnostic and Prognostic Challenges." Neurosurgery 88, no. 1 (2020): E114—E122. http://dx.doi.org/10.1093/neuros/nyaa357.

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ABSTRACT BACKGROUND AND IMPORTANCE In the setting of intracranial neoplasms, EWSR1-cAMP Response Element-Binding Protein (CREB) transcription factor family fusions have been described in myxoid mesenchymal tumors, extremely rare entities with a close histopathologic and immunologic resemblance to myxoid subtype angiomatoid fibrous histiocytomas (AFH). Controversy exists on whether these central nervous system lesions are a subtype of myxoid AFH or a completely separate entity, which entitles a distinct clinical behavior and, consequently, a different approach to management. Upon review of the

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22

Gibson, Sarah E., and Richard A. Prayson. "Primary Skull Lesions in the Pediatric Population: A 25-Year Experience." Archives of Pathology & Laboratory Medicine 131, no. 5 (2007): 761–66. http://dx.doi.org/10.5858/2007-131-761-pslitp.

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Abstract Context.—Primary skull lesions are rare in the pediatric population. The differential diagnosis of these lesions is broad and includes both congenital and acquired lesions. Previous studies of skull lesions in the pediatric population suggest that dermoid/epidermoid tumors are the most common childhood skull tumors. Objective.—To review the clinicopathologic features of primary skull lesions identified within the pediatric population of an academic tertiary medical center. Design.—A retrospective review of surgical pathology reports during a 25-year period identified 19 primary skull

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23

Barron, J., R. Hammond, D. Ramsay, S. Lownie, and D. Lee. "PRIMARY INTRACRANIAL MALIGNANT SOLITARY FIBROUS TUMOR." Journal of Neuropathology and Experimental Neurology 58, no. 5 (1999): 565. http://dx.doi.org/10.1097/00005072-199905000-00236.

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Gruttadauria, Salvatore, Cataldo Doria, Marta Ida Minervini, et al. "Malignant Fibrous Histiocytoma of the Gallbladder: Case Report and Review of the Literature." American Surgeon 67, no. 7 (2001): 714–17. http://dx.doi.org/10.1177/000313480106700727.

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Malignant fibrous histiocytoma is a soft tissue sarcoma of mesenchymal origin. It can rarely present as a primary gallbladder tumor with only five cases having been reported to date in the English literature. Here we report the sixth documented case of malignant fibrous histiocytoma of the gallbladder, and we review all other cases reported. The outcome of the visceral sarcomas is poor when compared with tumors arising from the soft tissues. The treatment of primary malignant fibrous histiocytomas of the gallbladder is surgery. However, tumor recurrence is the norm even if wide clean margins a

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Secco, Léo-Paul, Louis Libbrecht, Elsa Seijnhaeve, Silke Eggers, Anne-France Dekairelle, and An-Katrien De Roo. "Epithelioid Fibrous Histiocytoma with CARS-ALK Fusion: First Case Report." Dermatopathology 10, no. 1 (2023): 25–29. http://dx.doi.org/10.3390/dermatopathology10010003.

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Epithelioid fibrous histiocytoma (EFH) is a type of uncommon skin tumor mostly harboring Anaplastic Lymphoma Kinase (ALK) gene rearrangement, with different fusion partners reported. Whether this tumor is a separate entity or has a relationship with conventional fibrous histiocytomas is still a matter of debate. Benign course is the rule after complete surgical excision. A rare subtype of EFH with fusiform cells has been described, with specific fusion partners. Inflammatory myofibroblastic tumor (IMT) is a type of soft tissue tumor rarer than EFH, and it can display distant metastases. Some c

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Piombino, Eliana, Giuseppe Broggi, Mattia Barbareschi, et al. "Wilms’ Tumor 1 (WT1): A Novel Immunomarker of Dermatofibrosarcoma Protuberans—An Immunohistochemical Study on a Series of 114 Cases of Bland-Looking Mesenchymal Spindle Cell Lesions of the Dermis/Subcutaneous Tissues." Cancers 13, no. 2 (2021): 252. http://dx.doi.org/10.3390/cancers13020252.

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Purpose: to investigate the immunohistochemical expression and distribution of Wilms’ tumor 1 (WT1) (transcription factor produced by the tumor suppressor gene of the same name) in a series of 114 cases of bland-looking mesenchymal spindle cell lesions of the dermis/subcutaneous tissues to establish whether this immunomarker is differentially expressed in dermatofibrosarcoma protuberans (DFSP) versus its potential morphological mimickers. Methods: This retrospective multi-centric immunohistochemical study included 57 DFSP cases, 15 dermatofibromas, 5 deep fibrous histiocytomas, 8 neurofibromas

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Fernebro, Josefin, Ana Carneiro, Anders Rydholm, et al. "Genetic Profiling Differentiates Second Primary Tumors from Metastases in Adult Metachronous Soft Tissue Sarcoma." Sarcoma 2008 (2008): 1–7. http://dx.doi.org/10.1155/2008/431019.

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Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult.Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant subtype.Results. aCGH profiling revealed genetic complexity with multiple gains and losses in all tumors.

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Odzharova, A. A., A. I. Pronin, T. G. Gasparyan та Z. Kh Kamolova. "Positron emission tomography combined with computed tomography with <sup>18</sup>F-fluorodeoxyglucose and <sup>18</sup>F-сholine in meningeal solitary fibrous tumors: short literature review sample and clinical cases". Head and Neck Tumors (HNT) 12, № 2 (2022): 123–31. http://dx.doi.org/10.17650/2222-1468-2022-12-2-123-131.

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Solitary fibrous tumors of the cerebral membranes are rare brain tumors. meningeal solitary fibrous tumors often metastasize outside the central nervous system, which significantly reduces the life expectancy of patients, while metastases can appear in a distant period after radical treatment of the primary intracranial tumor. The results of positron emission tomography combined with computed tomography with 18F-fluorodeoxyglucose and 18F-choline in 2 patients with different differentiation of solitary fibrous tumors were analyzed. The presented clinical cases demonstrate that clinical morphol

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Hendrickson Rahmlow, Tara, Sandhya Kolagatla, Kathleen Mattingly, Jonathan Grube, Subramanya Shyam Ganti, and Nagabhishek Moka. "Liver Metastasis From Intracranial Hemangiopericytoma 8 Years After Initial Resection: Case Report." Journal of Investigative Medicine High Impact Case Reports 10 (January 2022): 232470962211322. http://dx.doi.org/10.1177/23247096221132244.

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Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare intracranial tumor that arises from pericytes surrounding the blood vessels. Solitary fibrous tumor/hemangiopericytoma accounts for less than 1% of primary brain tumors and is classified as grades I, II, or III based on mitotic count. These tumors often masquerade as meningiomas. Histologically, SFT/HPC is vascular with high cellularity and often surrounded by connective tissue. Immunohistochemistry is positive for stat 6, vimentin, and CD34. Although aggressive surgical resection is the mainstay of treatment, close long-term follow

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Bangolo, Ayrton, Pierre Fwelo, Kritika M. Iyer, et al. "Primary Cardiac Sarcoma: Clinical Characteristics and Prognostic Factors over the Past 2 Decades." Diseases 11, no. 2 (2023): 74. http://dx.doi.org/10.3390/diseases11020074.

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Background: Primary cardiac sarcomas (PCS) are extremely rare malignant tumors involving the heart. Only isolated case reports have been described in the literature over different periods of time. This pathology has been associated with a dismal prognosis and given its rarity; treatment options are very limited. Furthermore, there are contrasting data about the effectiveness of current treatment modalities in improving the survival of patients with PCS, including surgical resection which is the mainstay of therapy. There is a paucity of data on the epidemiological characteristics of PCS. This

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Reindel, J., W. Bobrowski, A. Gough, and J. Anderson. "Malignant Intracranial Teratoma in a Juvenile Wistar Rat." Veterinary Pathology 33, no. 4 (1996): 462–65. http://dx.doi.org/10.1177/030098589603300421.

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An intracranial malignant teratoma was identified in a 91-day-old male Wistar rat manifesting central nervous system-related clinical signs. This tumor occupied the right midbrain and portions of the right caudal cerebrum and cranioventral cerebellum. Microscopically, the tumor contained intermingled cartilage, bone (with medullary hematopoietic tissue), fibrous connective tissue, skeletal muscle, fat, pseudostratified ciliated epithelium, stratified squamous epithelium, serous and mucoserous glands, and neural tissue with ependymal and choroid plexus epithelia. Poorly differentiated cells wit

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Sun, Zhixiang, Feng Li, Xintao Cai, and Zhiquan Jiang. "Intracranial Primary Malignant Solitary Fibrous Tumor/Hemangiopericytoma Masquerading as Meningioma: Report of a Rare Case." International Journal of General Medicine Volume 13 (October 2020): 963–67. http://dx.doi.org/10.2147/ijgm.s279483.

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Zaheer, S., and G. M. Kleinman. "Primary Meningioma of the Middle Ear - A Rare Presentation." American Journal of Clinical Pathology 154, Supplement_1 (2020): S26. http://dx.doi.org/10.1093/ajcp/aqaa161.050.

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Abstract Introduction/Objective Meningiomas are the benign intracranial neoplasm, most commonly occurring in the third and sixth decade of life. The most common intracranial locations for meningiomas are parasagittal sinuses and large dural sinuses. Very rarely extracranial meningiomas can also be observed. We present a case of fibrous meningioma presenting as middle ear mass, in which a 13 years old female was presented with drainage from the left ear. Biopsy showed fibromyxomatous tissue. CT scan of the head showed soft tissue filling the middle ear and extending into the mastoid. Methods Th

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Reddy, Sumanth, Aaron Plitt, Jack Raisanen, et al. "Intracranial anaplastic hemangiopericytoma presenting with simultaneous extra-cranial metastases: A case report and review of the literature." Surgical Neurology International 10 (July 26, 2019): 148. http://dx.doi.org/10.25259/sni_111_2019.

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Background: Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare mesenchymal tumor with a propensity to recur and metastasize extracranially years after treatment. Accordingly, there are no reported cases of a patient presenting with a simultaneous intracranial primary and extracranial metastases. We present the case of a patient presenting with an intracranial SFT/HPC and simultaneous liver metastases and propose a treatment paradigm. Case Description: A 74-year-old male smoker presented with confusion. An MRI of the brain revealed a heterogeneously enhancing left fronta

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Patel, Arjun, David Palma, Nikhil Sangle, and Sondos Zayed. "Radiation management of a late thoracic metastasis from an intracranial solitary fibrous tumour." BMJ Case Reports 15, no. 11 (2022): e250862. http://dx.doi.org/10.1136/bcr-2022-250862.

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Solitary fibrous tumours (SFTs) are a rare soft tissue sarcoma. We present a case of a male patient with an SFT of the right posterior fossa, with a late metastasis to the right lung and chest wall identified 18 years later.A small number of late metastases of SFTs have previously been reported. Metastases are typically managed surgically, although there is limited evidence suggesting that radiotherapy may be effective for primary SFTs.In this case, the patient declined treatment for his metastasised cancer for 5 years. He then only agreed to radiation treatment without surgery, which uniquely

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Aggarwal, Vikram, Khush Kharidia, Han Wool Kim, and Eric Steen. "Synchronous presentation of recurrent intracranial solitary fibrous tumour and chronic myeloid leukaemia: a diagnostic challenge." BMJ Case Reports 17, no. 10 (2024): e260434. http://dx.doi.org/10.1136/bcr-2024-260434.

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Solitary fibrous tumours (SFTs) and chronic myeloid leukaemia (CML) are both uncommon neoplasms with distinct chromosomal aberrations and clinical presentations. Here, we present a case of a male in his late 50s with a history of intracranial SFT who presented 8 years after subtotal resection and adjuvant radiotherapy with splenic infarcts, a white blood cell of 83 000 cells/mL, and liver masses. He was treated with dasatinib for CML and temozolomide/bevacizumab for SFT. This case emphasises the benefits of broad differential diagnoses that include multiple concurrent disease processes when co

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Inoue, Eri, Natsuko Tanoe, Manoj Bohara, et al. "Solitary fibrous tumor of the orbit." Nepal Journal of Neuroscience 21, no. 3 (2001): 44–47. https://doi.org/10.3126/njn.v21i3.69225.

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Intracranial solitary fibrous tumor (SFT) / Hemangiopericytoma (HPC) is a rare mesenchymal tumor. The occurrence in the orbit is quite rare, with only 2/244 cases in the Japanese population of primary tumors in the orbit. Herein, we report the case of a 54-year-old woman who presented with right visual disturbance. The vision had worsened and was lost after a year. Three years later, magnetic resonance image (MRI) revealed a right intraorbital tumor, and 16 years later, swelling of the right eyelid and exophthalmos appeared. Computed Tomography scan revealed a well-defined homogeneous mass in

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Chelsky, Zachary L., Farres Obeidin, Borislav A. Alexiev, et al. "Methylation classifier array and classification of solitary fibrous tumors." Journal of Clinical Oncology 41, no. 16_suppl (2023): e23522-e23522. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e23522.

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e23522 Background: Solitary fibrous tumors (SFTs) are fibroblastic tumors which carry a characteristic NAB2::STAT6 gene rearrangement. SFTs represent a heterogenous group that may arise in multiple locations and have variable risk of progression. Despite a consistent oncogenic driver, there is little biological data explaining this variability. Recently, the German Cancer Research Network (DKFZ) have modified their brain tumor methylation classifier for use in sarcomas. We subjected solitary fibrous tumors diagnosed at our institution to a validated, in-house sarcoma methylation array classifi

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Ren, Xiaohui, Junmei Wang, Mengqing Hu, Haihui Jiang, Jun Yang, and Zhongli Jiang. "Clinical, radiological, and pathological features of 26 intracranial and intraspinal malignant peripheral nerve sheath tumors." Journal of Neurosurgery 119, no. 3 (2013): 695–708. http://dx.doi.org/10.3171/2013.5.jns122119.

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Object Intracranial and intraspinal malignant peripheral nerve sheath tumors (MPNSTs) are rarely reported because of their extremely low incidence. Knowledge about these tumors is poor. In this study the authors aimed to analyze the incidence and clinical, radiological, and pathological features of intracranial and intraspinal MPNSTs. Methods Among 4000 cases of intracranial and intraspinal PNSTs surgically treated between 2004 and 2011 at Beijing Tiantan Hospital, cases of MPNST were chosen for analysis and were retrospectively reviewed. To determine which parameters were associated with long

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Roser, Florian, Makoto Nakamura, Almuth Brandis, Volkmar Hans, Peter Vorkapic, and Madjid Samii. "Transition from meningeal melanocytoma to primary cerebral melanoma." Journal of Neurosurgery 101, no. 3 (2004): 528–31. http://dx.doi.org/10.3171/jns.2004.101.3.0528.

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✓ The authors describe the first case of an intracranial transition of a melanocytoma into a primary malignant melanoma within a short time. A 37-year-old woman presented with progressive brainstem syndrome due to a tumor, originally diagnosed and treated 12 years earlier, that extended from the petroclival area to the anterior craniocervical junction. The histological workup following subtotal tumor resection of the initial tumor had revealed the typical features of a fibrous melanocytic meningioma without increased proliferation. Ten years after the patient had completed treatment for the me

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Chugh, Rashmi, J. Kyle Wathen, Robert G. Maki, et al. "Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model." Journal of Clinical Oncology 27, no. 19 (2009): 3148–53. http://dx.doi.org/10.1200/jco.2008.20.5054.

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Purpose The purpose of this trial was to assess the efficacy of imatinib in patients with one of 10 different subtypes of advanced sarcoma. Patients and Methods Eligible patients were treated daily with imatinib dosed at 300 mg twice a day (for body-surface area ≥ 1.5 m2). The primary end point was response (clinical benefit response [CBR]), defined as complete (CR) or partial response (PR) at 2 months, or stable disease, CR, or PR at 4 months. Rules for early termination within each disease type were based on a Bayesian hierarchical probability model (BHM) accounting for correlation of the re

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Stone, J. B., R. Stonebridge, R. D. Bhuta, and J. L. Boxerman. "Anaplastic Lymphoma Kinase‐Positive Inflammatory Myofibroblastic Tumor Mimicking Meningioma: A Case Report." Neurographics 11, no. 2 (2021): 75–79. http://dx.doi.org/10.3174/ng.2000037.

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A 15-year-old girl presented with intermittent nausea and vomiting, headache, and vision changes. MR imaging of the brain revealed an avidly enhancing infratemporal dural-based mass arising from the tentorium, with hyperintensity on T2WI and transdural extension into the posterior cranial fossa. The well-encapsulated fibrous tumor was resected en bloc after cauterization of its rich tentorial arterial supply. Histologic examination demonstrated pleomorphic myofibroblastic cells admixed with an inflammatory infiltrate. Spindle cells showed strong, diffusely positive immunostaining for anaplasti

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Meloni, Marco, Salvatore Serra, Giulia Bellisano, Nikolaos Syrmos, Sanjeeva Jeyaretna, and Mario Ganau. "Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features." Case Reports in Surgery 2019 (July 16, 2019): 1–6. http://dx.doi.org/10.1155/2019/7105361.

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Background. Gliosarcoma (GS) represents a rare, high-grade (WHO Grade IV), central nervous system neoplasm, characterized by a very poor prognosis. Similar to other high-grade gliomas, GS affects mainly adults in the 5th-7th decade of life and presents a higher incidence in males. The most reported locations of GS are the temporal lobe and the frontal lobe, while only eight cases of GS originating from the posterior cranial fossa are reported in the literature. Case Description. We report the first case occurring during pregnancy in a 33-year-old patient. Diagnosis was obtained on the 15th wee

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Kim, Byung Sup, Yuil Kim, Doo-Sik Kong, et al. "Clinical outcomes of intracranial solitary fibrous tumor and hemangiopericytoma: analysis according to the 2016 WHO classification of central nervous system tumors." Journal of Neurosurgery 129, no. 6 (2018): 1384–96. http://dx.doi.org/10.3171/2017.7.jns171226.

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OBJECTIVEThe authors conducted this retrospective study to investigate the clinical outcomes of intracranial solitary fibrous tumor (SFT) and hemangiopericytoma (HPC), defined according to the 2016 WHO classification of central nervous system (CNS) tumors.METHODSHistopathologically proven intracranial SFT and HPC cases treated in the period from June 1996 to September 2014 were retrospectively reviewed and analyzed. Two neuropathologists reviewed pathological slides and regraded the specimens according to the 2016 WHO classification. Factors associated with progression-free survival (PFS) and

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Venkatasai, Jeyaanth, Vishal Manik, Kazumi Chia, Angela Swampillai, Omar Al-Salihi, and Lucy Brazil. "RADT-34. CLINICAL OUTCOMES OF LOCALISED AND METASTATIC CENTRAL NERVOUS SYSTEM HAEMANGIOPERICYTOMAS/SOLITARY FIBROUS TUMOURS – A SINGLE INSTITUTION EXPERIENCE." Neuro-Oncology 25, Supplement_5 (2023): v56. http://dx.doi.org/10.1093/neuonc/noad179.0223.

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Abstract BACKGROUND/OBJECTIVE Central nervous system (CNS) haemangiopericytomas (HPC) or solitary fibrous tumours (SFT) are rare aggressive tumours. Surgery is the primary modality of treatment, however, often followed by postoperative radiotherapy due to high tendency for local recurrence. Although rare, extracranial metastases to several sites have been described. We aim to report our institutional experience in managing these rare tumours. METHODS Patients with central nervous system HPC/SFT who underwent surgical resection from 2012 to 2022 were included in the study. Data collected includ

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Jiang, Jingcheng, Xiaoqin Qu, Han Wang, et al. "Application and effect evaluation of microsurgical resection combined with intensity-modulated radiation therapy in the treatment of intracranial solitary fibrous tumor/hemangiopericytoma." Medicine 104, no. 6 (2025): e41336. https://doi.org/10.1097/md.0000000000041336.

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Intracranial solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare mesenchymal tumors with significant vascularization, often misdiagnosed as meningiomas. Surgical resection is the primary treatment, with postoperative radiotherapy increasingly recognized for its role in improving recurrence-free survival. However, standard radiotherapy regimens remain undefined. We retrospectively analyzed clinical data from 12 patients diagnosed with SFT/HPC who underwent surgical resection and postoperative intensity-modulated radiotherapy. Clinical information, imaging findings, treatment meth

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Sameeta, F., S. Liu, S. R. Avalos Hernandez, O. Elkadi, and G. Herrera. "Basal Ganglia Intracranial Mixed Germ Cell Tumor With Predominance of Yolk Sac Component." American Journal of Clinical Pathology 154, Supplement_1 (2020): S46—S47. http://dx.doi.org/10.1093/ajcp/aqaa161.099.

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Abstract Introduction/Objective Primary intracranial germ cell tumors (ICGCTs) represent a rare heterogenous group of neoplasms with an overall incidence of 3% of all pediatric brain tumors. ICGCTs are classified into germinomatous and non-germinomatous tumors and approximately 25% are mixed, and contain more than one histologic component. Most ICGCTs are located in suprasellar and pineal regions with some occurring in rare locations such as basal ganglia, thalamus and fourth ventricle. Methods In our case, A 9-year-old Asian-American male presented with headaches and a few weeks history of un

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Rouleau, C., W. Weber, R. Bagley, et al. "Endosialin/TEM1: Cellular localization and prevalence in soft-tissue tumors and carcinomas." Journal of Clinical Oncology 25, no. 18_suppl (2007): 20520. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20520.

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20520 Background: Tumors grow more slowly in endosialin/TEM1 KO mice compared to WT, suggesting that host endosialin/TEM1-positive stroma promotes malignancy (Nanda, PNAS, 2006). Methods: We surveyed 92 human clinical samples by IHC (52 epithelial tumors, 40 sarcomas) to measure the extent of endosialin/TEM1 expression and assess cellular localization. Expression was also studied in primary cell cultures and 49 cancer lines. Results: 46/52 adenocarcinomas and carcinomas (88.5%) expressed endosialin/TEM1 mainly in pericytes (7/7 bladder, 7/11 breast, 5/5 colon, 7/8 ovarian, 7/7 renal, 2/2 liver

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Rivera, Jonathan P., and Jose M. Carnate. "Sinonasal Tract Meningioma." Philippine Journal of Otolaryngology-Head and Neck Surgery 32, no. 2 (2018): 60–61. http://dx.doi.org/10.32412/pjohns.v32i2.89.

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A 63-year old Filipino female presented with epistaxis of undisclosed duration. Examination showed a vascular, pulsating, rubbery intranasal mass involving both nasal cavities. The clinical impression was that of a nasal hemangioma. She underwent excision of the tumor and the specimen was sent for histopathologic evaluation.  The specimen consisted of several tan-brown irregular tissue fragments with an aggregate diameter of 2 cm. Microscopic examination showed a cellular spindle cell tumor underneath the respiratory mucosa. (Figure 1) The tumor cells formed a syncytial pattern arr

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Panu, Liévin, Salma Lahlou, Amine Naja, et al. "Meningiomas in Elderly Subjects: Retrospective Studies of 8 Cases and a Literature Review." European Journal of Medical and Health Sciences 6, no. 5 (2024): 19–25. http://dx.doi.org/10.24018/ejmed.2024.6.5.2165.

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Aim. Intracranial meningiomas in adults are mainly benign tumors that develop from the meninges. They are common, accounting for about 18 to 20% of primary intracranial tumors, and they are slow-growing, with a predominance in women. They can occur at any age but are most common after the age of 56. Symptoms vary depending on the location of the tumor, its size, and the anatomical structures it comes into contact with. Surgery is the main treatment modality for meningiomas. The objective of this study is to evaluate the cases of meningiomas in our series and to compare their different aspects,

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