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Rozprawy doktorskie na temat „Progression”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Marchetto, Raquel. "O uso do software GeoGebra no estudo de progressões aritméticas e geométricas, e sua relação com funções afins e exponenciais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/172105.

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Esta pesquisa teve por objetivo verificar como é que o aluno consegue por si próprio manipular os recursos, tais como gráficos disponibilizados pelo software GeoGebra, para auxiliar nas práticas diárias de sala de aula, mais especificamente no que tange a construir a conexão entre as progressões aritméticas e as funções afins, bem como entre as progressões geométricas e as funções exponenciais. Este software possibilita fazer análises a partir de diferentes registros tais como: gráficos, tabelas e registros algébricos, seguindo a teoria dos registros semióticos de Duval. Como metodologia, dese

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Cergoli, Daniel. "Ensino de logaritmos por meio de investigações matemáticas em sala de aula." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/45/45135/tde-29112017-171710/.

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Neste trabalho são apresentadas duas propostas de sequências didáticas para ensino de logaritmos. A primeira delas é destinada ao aperfeiçoamento de professores de Matemática e a outra, para alunos de Ensino Médio. Tais sequências foram desenvolvidas com base em pesquisas realizadas pelo Prof. João Pedro da Ponte sobre o processo de investigação matemática. A sequência didática para professores foi aplicada no Centro de Aperfeiçoamento do Ensino de Matemática do Instituto de Matemática e Estatística da Universidade de São Paulo (CAEM IME USP). Já a sequência para alunos foi aplicada em uma e

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3

Biani, Rosana Prado. "A progressão continuada rompeu com mecanismos de exclusão?" [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/252086.

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Orientador : Maria Marcia Sigrist Malavasi<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação<br>Made available in DSpace on 2018-08-09T13:29:41Z (GMT). No. of bitstreams: 1 Biani_RosanaPrado_M.pdf: 2081184 bytes, checksum: f73b85e1cce9e4a11a8ec0bf5ab598d2 (MD5) Previous issue date: 2007<br>Resumo: Este trabalho analisa a seletividade, o fracasso escolar e a exclusão após a implantação da Progressão Continuada na rede escolar pública estadual de São Paulo. Situa-se na perspectiva do materialismo histórico dialético, sua abordagem é qualitativa e sua metodolo

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4

Josefsson, Erik. "Progression of ancestral brutalism." Thesis, Högskolan i Borås, Institutionen Textilhögskolan, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-17068.

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Within the fine arts, clean and flat structures functionas a narrator for the clean, modern and hightech society. A society with a hygienic fear of death, illness and chaotic structures. The aim of the work is through the materialand surface inflict the hidden, the other side, the darkness and death, in strict and formal mens archetype garments.<br>Program: Modedesignutbildningen

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5

Hjeltman, Måsse, and Thomas Ivarsson. "Historieläromedelsböcker, genus & progression." Thesis, Malmö högskola, Lärarutbildningen (LUT), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-33118.

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I denna undersökning ämnar vi ta reda på hur progressionen ser ut gällande framställningen av kvinnor i historieläromedel från 1960-talet till år 2007. Vi har fokuserat kring dem som oftast marginaliserats i innehållet till fördel för de politiska aktiva så som drottningar och andra politiker. Här är det istället bondhustrur, den hemarbetande kvinnan, sömmerskor, hantverkare och andra yrkesarbetande kvinnor som undersöks för att ta reda på om de har en större plats i dag jämfört med på 1960-talet. Vi vill också ta reda på vilket sätt de framställs och har framställts. Är de aktiva och driver h

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6

Strouthidis, N. G. "Measuring progression in glaucoma." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446208/.

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Background: Primary open angle glaucoma is characterised by progressive optic neuropathy associated with characteristic visual field loss. The ability to measure disease progression is of vital importance in the management of patients with glaucoma. Conventionally, disease progression has been monitored using static automated perimetry. Recently, devices which image the optic nerve head quantifiably have been introduced. This thesis sets out to compare structural and functional progression in ocular hypertensive subjects followed longitudinally using novel progression algorithms. Plan of resea

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7

Ambring, Erik. "Gameplay Progression : Om skapandet av en jämn progression av spelmoment till dataspelet Testament." Thesis, University of Skövde, School of Humanities and Informatics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3162.

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<p>Det här arbetets slutgiltiga uppgift har varit att skapa ett första utkast till enövergripande plan för en jämn fördelning av spelmoment för spelet Testament, ett spel som utvecklas för Svenska Kyrkan med syfte att användas inom konfirmandundervisning. Med spelmoment menas exempelvis story, miljö, utrustning och liknande.</p><p>Arbetet ger inledningsvis en kort översikt över hur leveldesignen inom dataspel har utvecklats och går därefter in på det mer specifika området gameplay progression, utvecklat av Mike Lopez, som ger en översyn över vad som krävs för att skapa ett spel med en jämn för

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8

Costa, Antonio Carlos de Lima. "O estudo de Induções e Recorrências - uma abordagem para o Ensino Médio." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8064.

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Submitted by Maike Costa (maiksebas@gmail.com) on 2016-03-30T11:36:15Z No. of bitstreams: 1 arquivo total.pdf: 1989591 bytes, checksum: c1b3f2740144367fd7ef458d0603ba20 (MD5)<br>Approved for entry into archive by Viviane Lima da Cunha (viviane@biblioteca.ufpb.br) on 2016-03-30T15:42:56Z (GMT) No. of bitstreams: 1 arquivo total.pdf: 1989591 bytes, checksum: c1b3f2740144367fd7ef458d0603ba20 (MD5)<br>Made available in DSpace on 2016-03-30T15:42:56Z (GMT). No. of bitstreams: 1 arquivo total.pdf: 1989591 bytes, checksum: c1b3f2740144367fd7ef458d0603ba20 (MD5) Previous issue date: 2015-02-26<

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9

Reichart, Sven. "Progression nach kurativer kolorektaler Karzinomchirurgie." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-99172.

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10

Hung, Tzong Tyng Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "Studies of bladder cancer progression." Awarded by:University of New South Wales, 2009. http://handle.unsw.edu.au/1959.4/39786.

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Bladder cancer (BlCa) is the second most common genitourinary cancer, affecting both men and women. Most (70%) cases present at the superficial stage; 20% of these recur with muscle-invasive disease. Major genetic alterations associated with BlCa include: loss/gain in expression or mutations in Retinoblastoma (RB) gene, human epidermal growth factor receptors (HERs), H-ras, p53 and FGFR3. Only p53 mutations are well correlated with invasive BlCa; other changes show variable correlations with disease status. To understand the progression of BlCa, a model of nine human BlCa cell sublines derived

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Hung, Tzong-Tyng Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "Studies of bladder cancer progression." Awarded by:University of New South Wales. Clinical School - Prince of Wales Hospital, 2007. http://handle.unsw.edu.au/1959.4/40450.

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Bladder cancer (BICa) is the second most common genitourinary cancer, affecting both men and women. Most (70%) cases present at the superficial stage; 20% of these recur with muscle-invasive disease. Major genetic alterations associated with BICa include: loss/gain in expression or mutations in Retinoblastoma (RB) gene, human epidermal growth factor receptors (HERs), H-ras, p53 and FGFR3. Only p53 mutations are well correlated with invasive BICa; other changes show variable correlations with disease status. To understand the progression of BICa, a model of nine human BICa cell sublines derived

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12

Moroz, Kelly. "Drug use, initiation and progression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0020/MQ55227.pdf.

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13

Horsford, Bernard I. "Career progression of black managers." Thesis, Cranfield University, 2003. http://hdl.handle.net/1826/4275.

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This research programme examined the factors that affect the career progression of Black managers in the United Kingdom. The research comprised two distinct but related studies. The first study was a qualitative investigation of the factors affecting the career progression of Black managers (n = 64). The main finding from the first study was that for some the achievement of high salaries and senior positions may be at the expense of one's positive Black racial identity attitudes and wellbeing. The second study was a quantitative examination of aspects revealed as important correlates of career

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14

Shahrabi, Farahani Hossein. "Computational Modeling of Cancer Progression." Doctoral thesis, KTH, Beräkningsbiologi, CB, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-121597.

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Cancer is a multi-stage process resulting from accumulation of genetic mutations. Data obtained from assaying a tumor only contains the set of mutations in the tumor and lacks information about their temporal order. Learning the chronological order of the genetic mutations is an important step towards understanding the disease. The probability of introduction of a mutation to a tumor increases if certain mutations that promote it, already happened. Such dependencies induce what we call the monotonicity property in cancer progression. A realistic model of cancer progression should take this pro

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15

Li, Weiling. "Genetic changes in melanoma progression." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5595.

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Melanoma is a highly aggressive tumour with a poor prognosis for patients with advanced disease because it is resistant to current therapies. Therefore, the development of novel strategies for melanoma treatment is important. The characterization of the molecular mechanisms underlying melanoma proliferation, progression, and survival could help the development of novel targeted melanoma treatments. The MAPK and PI3K pathways both play important roles in melanoma progression. In the MAPK pathway, DUSP6, which acts as a phosphatase to negatively control the activation of ERK1/2, is involved in t

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16

Johnson, Timothy Scott. "Transglutaminase apoptosis and tumour progression." Thesis, Nottingham Trent University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283035.

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17

Chan, Yin-Ping Rita. "Thematic progression in educational text." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252733.

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Chuprovska, Yu Ya. "Characteristics of breast cancer progression." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18208.

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19

Jansson, Alexander. "Strategic conditions for negotiation progression." Thesis, Uppsala universitet, Institutionen för freds- och konfliktforskning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413153.

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This thesis investigates conditions for formal negotiation onset. The cases that are investigated are found in the overarching conflict between the Government of Colombia and the guerilla group, Ejército de Liberación Nacional (ELN). The thesis argues that ideology and ecological rationality set the framework for disputant negotiation strategies and that disputants decide whether to progress negotiations to an elevated stage based on their perceived relative strategic position. It is hypostasized, firstly, that the disputants go to formal negotiations when the guerilla perceives itself in a

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20

Russell, Michael L. "The Phenomenology of Harmonic Progression." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703408/.

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This dissertation explores a method of music analysis that is designed to reflect the phenomenology of the listening experience, specifically in regards to harmony. It is primarily inspired by the theoretical approaches of the music theorist Moritz Hauptmann and by the writings of philosopher Edmund Husserl.

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21

Hutchings, Natalie. "Identification of visual field progression." Thesis, Aston University, 1996. http://publications.aston.ac.uk/14548/.

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The study developed statistical techniques to evaluate visual field progression for use with the Humphrey Field Analyzer (HFA). The long-term fluctuation (LF) was evaluated in stable glaucoma. The magnitude of both LF components showed little relationship with MD, CPSD and SF. An algorithm was proposed for determining the clinical necessity for a confirmatory follow-up examination. The between-examination variability was determined for the HFA Standard and FASTPAC algorithms in glaucoma. FASTPAC exhibited greater between-examination variability than the Standard algorithm across the range of s

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22

Cahlin, Christian. "Cyclooxygenase activity and tumor progression /." Göteborg : Departments of Surgery and Transplantation, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/18198.

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Riordan, Edward A. "Imaging markers for osteoarthritis progression." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20347.

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Joint damage in osteoarthritis (OA) involves characteristic changes in multiple joint tissue types, with alterations in the shape of subchondral bone and composition of synovial fluid occurring concomitantly with cartilage damage. Systemic risk factors such as obesity and local biomechanical processes that determine joint loading have long been shown to predispose to the disease, and more recent evidence suggests that specific genetic loci and inflammatory processes may make contributions, but the exact mechanisms driving the initiation and progression of the disease are yet to be elucidated.

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CERESA, DAVIDE. "Clonal tracking of Glioma progression." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/977087.

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Khaleeli, Z. "Understanding progression in primary progressive multiple sclerosis : a longitudinal clinical and magnetic resonance imaging study." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19213/.

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The work in this thesis applies magnetization transfer imaging (MTI) and conventional MRI measures (brain volume, T2 lesion load and enhancing lesions) to investigate the mechanisms underlying progression in primary progressive multiple sclerosis (PPMS), and identifies MR markers to predict and monitor progression. First, we demonstrated that MTI was sensitive to change in the normal appearing brain tissues over one year, and that clinical progression over this period was predicted by baseline normal appearing white matter (NAWM) MT ratio (MTR). However, our second study showed that over three

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Verma, Kuldeep Kumar. "Different ladders for police progression? : reviewing black and minority officers' progression in the police service." Thesis, University of Portsmouth, 2015. https://researchportal.port.ac.uk/portal/en/theses/different-ladders-for-police-progression(f30809ef-d3dd-419c-b7a5-1c83c9c812cc).html.

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The Police Service has a strategic priority to improve approaches to progression forunder-represented groups; however, it is facing continued challenges for this priority, as there is a lack of progression for Black and Minority Ethnic (BME) officers. There are implicit suggestions in policy that increasing BME officers in the police would improve police culture in the form of attenuating the racism that may be creating barriers to recruitment and progression. Reform efforts have taken place in the UK Police Services in the last decade to have a more diverse workforce, especially with regard t

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Rosa, Marcella Suelma de Torrecillas. "Expressão tecidual e sérica de microRNAs associados a receptores de estrógeno e progesterona em meningiomas grau I, II e III." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-09112018-110503/.

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Os meningiomas são os tumores primários do Sistema Nervoso Central (SNC) mais frequentes e representam 35,5% dos casos considerando-se todas as faixas etárias. Apesar dos progressos ocorridos nas últimas décadas, a tumorigênese dos meningiomas ainda permanece como um desafio. Há um consenso da necessidade de ferramentas moleculares para ajudar tanto no diagnóstico quanto no prognóstico dos meningiomas. Neste contexto, alguns trabalhos demonstram a importância do papel dos receptores de estrógeno e progesterona, assim como o entendimento das alterações nos níveis de expressão dos microRNAs (miR

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Carneiro, Vinicius Marques. "Perfil de expressão tecidual e plasmática dos microRNAs miR-130a, miR-181c e miR-181d em meningiomas grau I, II e III." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-01022016-155451/.

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Introdução: Os meningiomas são neoplasias intracranianas de crescimento lento que se originam das células meningoteliais da aracnoide e representam os tumores intracranianos mais comuns, contabilizando 13-26% deste total, sendo um dos primeiros tumores sólidos a terem alterações genéticas identificadas. Inúmeros tem sido os avanços para a melhor compreensão das vias moleculares correlacionadas com a tumorigênese e progressão tumoral dos meningiomas, neste contexto tem se destacado o papel dos microRNAs que são RNAs não-codificantes (ncRNAs) constituídos por 19 a 25 nucleotídeos, cuja função é

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Andrade, Afonso Martins. "Avaliação, ciclo e progressão no ensino de matemática: uma consequência refletida ou uma saída aleatória?" Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-12062008-132214/.

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Esta pesquisa é resultado da minha inquietação e do desconforto produzido ao longo dos últimos anos de atuação no magistério público, levando-me a questionar as hipóteses elaboradas e as finalidades identificadas na construção dos caminhos que culminaram na adoção do sistema de ciclos com progressão continuada implantado no Ensino Fundamental na Rede Pública de Ensino do Estado de São Paulo. Tendo como base tal inquietação, o objetivo deste trabalho é compreender melhor tal elaboração assim como de que maneira a ausência de novos métodos, estratégias e instrumentos de avaliação pode ser vista

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Gallégo, Hélène. "Progression de l'athérosclérose après angioplastie des coronaires : une analyse multivariée des relations entre progression et resténose." Bordeaux 2, 1989. http://www.theses.fr/1989BOR23024.

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Ibrahimi, Merita, and Flurije Bajrami. "Svenska som andraspråk : Arbetssätt för progression." Thesis, Linnéuniversitetet, Institutionen för pedagogik, psykologi och idrottsvetenskap, PPI, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-18577.

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Hörkkö, T. (Tuomo). "Growth and progression in colorectal cancer." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514282809.

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Abstract Colorectal cancer is the second most common malignancy in the Western World. The overall 5-year survival is still only 50–60%. Thus, better prognostic markers are needed to improve survival of the disease. Most colorectal cancers develop from pre-existing adenomas including conventional, flat and serrated adenomas. The most important prognostic factors include tumour stage, histologic subtype and poor differentiation. The prognosis of colorectal cancer depends mainly on tumour stage. The growth of colorectal cancer is determined by cell proliferation, differentation and apoptosis. Th

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Quaglia, Alberto. "Mechanisms of progression in hepatocellular carcinoma." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271505.

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Rowan, Mark Stephen. "Information-selectivity of Alzheimer's disease progression." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4328/.

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Homeostatic synaptic scaling mechanisms, which normally balance potentiation during learning, may direct the progression of the disease throughout the brain as cells scale up their sensitivity to compensate for lost activation. Such a mechanism would be likely to target those cells with the lowest contribution of information to the network in early stages of the disease, resulting in delayed onset of cognitive symptoms and making timely intervention and treatment of the disease more difficult. These predictions were investigated in a Hopfield-type neural network. Lesioning according to the sca

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Ng, Grace. "Genomic investigations of cervical cancer progression." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613036.

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Vedhara, Kavita. "A psychoneuroimmunological investigation into HIV progression." Thesis, University of Newcastle upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260956.

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Bengtsson, Filip, and Philip Undin. "Moderna progression system, en kooperativ regress." Thesis, Blekinge Tekniska Högskola, Institutionen för teknik och estetik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-12935.

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Digitala spel är ett av dagens största digitala medier där det dagligen släpps nya spel. En av de största spel-genrerna är multiplayer First-Person Shooter (FPS) spel. Inom multiplayer FPS-spel, där kooperativt lagsamarbete spelar stor roll, har det på senare år uppkommit en trend där de flesta av dessa spel innehåller progression system som kan vara direkt skadande för spelets kooperativa upplevelse. Genom att undersöka frågeställningen “Hur kan vi med hjälp av progression system göra moderna FPS-spel mer kooperativa?” har vi försökt ta fram hur spelutvecklare istället kan öka den kooperativa

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Laranjeira, Simão. "Modelling the progression of neurodegenerative diseases." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:ebb621d0-e4e6-405e-9e54-ba385c3ebd0a.

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Neurodegenerative disease is an umbrella term for pathologies that primarily damage neurons. As their incidence increases with age it is becoming of a greater concern for the west, due to its aging population. Due to their chronic nature and the difficulty to create reliable and reproducible animal models of these diseases their pathophysiologies are still poorly understood. For all these reasons, a mathematical modelling approach is suggested. The methodology of the work here consisted of identifying the state of the art models that describe the healthy behaviour of cells (e.g. metabolism and

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Santos, Carlo Steven. "Circadian Control of Cell Cycle Progression." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/76987.

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Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint pathways involve a p53 dependent pathway which can trigger the cell to go through cell arrest or programmed cell death4. Understanding all the mitigating factors involved in regulating cell cycle progression under DNA damage can offer a better idea in how cells become immortal. Initially discovere

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Wilson, William. "Kant on the Progression of Representation." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/77888.

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Recently, the key point of contention in Kant scholarship has revolved around a question concerning whether, for Kant, intuitions can play their role of presenting objects to the mind without the discursive activity of the intellect. According to 'conceptualist' interpretations, intuitions depend for their generation on the activity of the understanding. According to 'nonconceptualist' interpretations, at least some intuitions do not depend for their generation on the activity of the understanding. I argue that although the conceptualism/nonconceptualism debate has brought greater clarity to a

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Flaten, Kayla. "The Progression of Agile Software Development." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1717.

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This paper examines the use of Agile Software Development in the technology industry and how it came to be one of the leading models used in project management. By investigating the software development methods used in the late 1900s, it becomes clear where the system needed improvement in order to improve the efficiency in developing products. In investigating the Agile Manifesto, new and essential components are introduced that become vital in successfully producing a product. From this, it is easier to understand why Agile is so commonly used in the software development industry and how it

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Khoynezhad, Shirin. "Halofuginone Prevents the Progression of Osteoarthritis." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331948.

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Background: Halofuginone (HF) is a natural product that has been shown to have therapeutic benefits in a variety of pathologic conditions, from cancer to autoimmune diseases. These beneficial effects are mainly through inhibition of pro-inflammatory cytokines. Inflammatory cytokines have been recently shown to exert a crucial role in development of osteoarthritis and one of their most important targets is Matrix metallopeptidase-13 (MMP-13). In this preclinical study, we investigated the effect of HF on the progression of Osteoarthritis. Methods: The effect of adding HF ± IL-1β/TNF-α on mRNA

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Sou, Paul Wing. "Cell‐cell interactions in tumour progression." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13961.

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Background: When EMT arises in carcinomas, it is often localised, the tumours being composed of both cells that have undergone an EMT, and cells that have retained epithelial characteristics. We hypothesised that these two cancer cell populations can cooperate to increase malignancy. Aim: To test Snail2 and the G12V mutant form of Hras for the ability to cooperate to increase malignancy when they are present in different clones. Methods: Snail2 and Hras were expressed in head and neck squamous cell carcinoma (HNSCC) cells as fluorescent protein fusions, enabling us to follow the behaviour of i

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Algotar, Amit Mohan. "RISK FACTORS FOR PROSTATE CANCER PROGRESSION." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195437.

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Introduction: This dissertation seeks to identify novel, potentially modifiable risk factors that could be used to reduce the risk of prostate cancer (PCa) progression. Aim 1 investigates the effects of obesity and smoking on PCa progression, aim 2 studies the effects of specific medication use on PCa progression, and aim 3 identifies factors associated with faster PCa progression.Methods: Data from 140 subjects from the Watchful Waiting study followed every 3 months for up to 5 years were used. Multiple linear regressions were used to determine associations with baseline PSA. PSA velocity (ra

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Romano, Elena. "Role of TFF1 in tumor progression." Doctoral thesis, Universita degli studi di Salerno, 2017. http://hdl.handle.net/10556/2573.

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2015 - 2016<br>Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It is expressed in the gastrointestinal tract, where plays an essential role in mucosal protection through mucous-barrier formation, and also in mucosal repair through promotion of restitution after injury. In recent years clinical and experimental studies have shown an active function of the trefoil peptides in the genesis of neoplastic processes. TFF1 is mainly as

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SOKOLOVA, VIKTORIJA. "MICRORNA INVOLVEMENT IN COLON CANCER PROGRESSION." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/214611.

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Loss of response to TGF-β occurs in many cancers and disruption of its regulatory circuitry appears as a central event in the genesis of colorectal cancer (CRC) malignancy. Lack of an inhibitory response to TGF-β is common to most colon cancer cell lines. Recently, abrogation of the TGF-β growth inhibitory response mediated by different miRNAs has been reported. By searching for miRNAs in regions showing copy number changes and concordant gene expression in 36 sporadic CRCs compared to their normal counterpart, we identified the miR-17-92 cluster localized on the 13q31 locus, gained and highly

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Sauty, Benoît. "Multimodal modelling of Alzheimer's Disease progression." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS348.

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La maladie d'Alzheimer (MA) est une pathologie multi-facette qui peut être surveillée grâce à une grande variété de modalités de données. Cette thèse vise à exploiter des données longitudinales multimodales, principalement des données d'imagerie et des tests cognitifs, pour fournir une description statistique de la progression de la MA et permettre une prévision individuelle de la dégradation future. Les modèles de progression à effet-mixtes de la maladie (DPMs) sont couramment utilisés pour ces tâches. Dans ce contexte, notre première contribution remet en question l'hypothèse fréquente selon

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Maero, Athanasius Lutta. "Assessing treatment outcomes of people living with HIV on antiretroviral therapy at Kakamega County General Hospital in Kenya." University of the Western Cape, 2019. http://hdl.handle.net/11394/6891.

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Magister Public Health - MPH<br>Background: The goal of ART therapy is sustained viral load suppression with good immunological and clinical response. This optimal response to therapy results in the prevention of emergent ART drug-resistant mutations, decrease morbidity, and AIDS-related mortality and sustained retention on ART. Kenya, like most countries in Sub-Saharan Africa, has scaled-up the use of ART and is currently implementing a “Test and Treat” strategy in which any client identified and confirmed with an HIV diagnosis is initiated ART. Few studies have been carried out to ascertain

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M'Hammed, Oubella Abdelkrim. "Progression narrative et progression thématique dans "l'enfant de sable" et "la nuit sacrée" de Tahar Ben Jelloun." Paris 3, 1992. http://www.theses.fr/1993PA030085.

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Nous avons essaye d'aborder, premierement, dans notre travail de these, la naissance et l'evolution de la litterature marocaine d'expression francaise. D'autre part, nous avons examine les fonctions et les fonctionnements de la couverture, du titre, et de l'incipit. Par ailleurs, la presence de plusieurs voix differentes dans "l'enfant de sable" nous a pousse a s'attarder sur les instances enonciatives dans ce roman. Le traitement de la narration dans "la nuit sacree" est plus chronologique a cause du respect relatif des successions des evenements romanesques. Nous avons tente, a la fin de not

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Raghavan, Kesav. "Progression Rates and Sample Size Estimates for Primary Progressive Multiple Sclerosis Based on the CLIMB Study Population." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295863.

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Background: The clinical trial design for primary progressive multiple sclerosis (PPMS) requires understanding of disability progression in modern patient cohorts. Objective: To characterize demographic and clinical characteristics of the CLIMB study (Boston, MA) PPMS patient cohort and assess rate of disability progression. Methods: We studied PPMS (n = 73) and relapsing-onset MS (ROMS) patients (n =1541) enrolled in CLIMB, a longitudinal study of MS patients at the Brigham and Women’s Hospital (Boston, MA). Disability progression for each group was compared using interval-censored survival a

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