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Rozprawy doktorskie na temat „Prostaglandin”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Venturin, Gabriela Lovizutto. "Efeito regulador da PGE2 na produção de TNF-α e IL-17 na atividade microbicida na leishmaniose canina. /". Araçatuba, 2019. http://hdl.handle.net/11449/183297.

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Orientador: Valéria Marçal Felix de Lima<br>Resumo: A leishmaniose canina (CanL) é causada pelo parasito intracelular Leishmania infantum. Devido ao alto parasitismo na pele o cão é considerado o principal reservatório urbano da L. Infantum. A prostaglandina-E2 (PGE2) possui propriedades reguladoras potentes do sistema imunológico e pode se ligar aos receptores EP1, EP2 e EP4 que geram ativação celular ou EP3 que gera inibição de resposta celular. Na CanL o papel regulador da PGE2 ainda não foi estudado, por isso, os parâmetros foram avaliados em cultura de leucócitos esplênicos de cães com Ca

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2

Javed, T. "Synthesis of prostaglandins and prostaglandin analogues from norbornadiene." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356170.

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Nielsch, A. S. "Effects of prostaglandins and prostaglandin synthetase inhibitors on liver toxicity." Thesis, University of Aberdeen, 1987. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU499301.

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A total of 22 non-steroidal anti-inflammatory drugs and derivatives were added to microsomes to study the denaturation of cytochrome P-450 to cytochrome P-420 in the absence of an NADPH-generating system. There was a highly significant correlation among the different compounds between the extent of denaturation of cytochrome P-450 and their surfactant potency. Endotoxin administration to rats caused a maximum decrease in hepatic microsomal enzymes after 24 hours. Significant decreases in cytochrome P-450 (40%), cytochrome b5 levels (22%), aminopyrine N-demethylase (31%) and biphenyl 4-hydroxyl

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4

Ujjan, Safdar Ali. "Prostaglandin D2 (PGD2) signalling and male germ cell : differentiation in the mouse embryonic testis." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20099.

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La détermination du sexe et la différenciation des cellules germinales est un processus très organisé qui commence au stade embryonnaire et se termine à la vie adulte. Dans les gonades embryonnaires l'expression de Sry suivie par l'expression de Sox9 initie le développement testiculaire tandis que, en l'absence de l'expression de Sry, les gènes associés au sexe féminin initient le développement des ovaires. Les cellules germinales qui ont migré vers les gonades nouvellement formées continuent leur prolifération intense jusqu'à ce qu'ils s'engagent dans la voie le mâle ou femelle. La décision d

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5

Gagliolo, Jean-Marie. "Rôle de la sénescence des fibroblastes dans la physiopathologie de la bronchopneumopathie chronique obstructive." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST1065.

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La sénescence, perte irréversible des capacités réplicatives des cellules associée à la sécrétion de médiateurs inflammatoires, pourrait participer au développement de l'atteinte pulmonaire dans la bronchopneumopathie chronique obstructive (BPCO) en initiant, maintenant et propageant un état inflammatoire. L'objectif de ce travail était d'évaluer les mécanismes de la sénescence impliqués dans l'induction et le maintien de l'inflammation au cours de la BPCO. Ainsi, des fibroblastes pulmonaires de témoins et de patients atteints de BPCO ont été mis en culture à long terme. Un phénotype sénescent

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6

Pereira, Priscilla Aparecida Tartari. "Efeitos antagônicos da prostaglandina D2 e prostaglandina E2 na resposta imune durante infecção experimental por Histoplasma capsulatum." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-06012014-081806/.

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O Histoplasma capsulatum é um fungo dimórfico, patogênico e responsável por graves lesões pulmonares. A infecção é adquirida pela inalação de conídios e posterior conversão para leveduras nos alvéolos e bronquíolos, onde são fagocitadas por macrófagos alveolares residentes e leucócitos que migram para o local da infecção. Recentemente, demonstramos que animais infectados com H. capsulatum e tratados com inibidor da síntese de prostaglandinas apresentaram diminuição de carga fúngica nos pulmões e baço, aumento da produção de nitrito e da fagocitose de leveduras por macrófagos alveolares, e maio

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7

Oliveira, Milena Lopes. "Ação do 17β-estradiol na síntese de PGF2α endometrial em vacas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-25082017-095013/.

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O 17β-E2 estimula a expressão de receptores endometriais, ER e OXTR. A ativação de OXTR induz a ativação da cadeia de síntese de PGF2α. A hipótese do presente estudo é que as enzimas de síntese de PGF2α são reguladas pelo 17β-E2. Objetivou-se determinar os efeitos do 17β-E2 na expressão gênica e proteica, assim como na localização de proteínas envolvidas na síntese de PGF2α. Vacas Nelore multíparas, solteiras e cíclicas foram sincronizadas por aplicação de BE e inserção de dispositivo de P4. Após 8 dias realizou-se a remoção do dispositivo de P4 e aplicação de PGF

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8

Feltrin, Isabella Rio. "Efeitos do 17β-estradiol na abundância de transcritos para enzimas envolvidas na síntese de PGF2α endometrial em fêmeas bovinas no final do diestro". Botucatu, 2020. http://hdl.handle.net/11449/192193.

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Orientador: Claudia Maria Bertan Membrive<br>Resumo: Em bovinos, o 17β-estradiol (17β-E2) estimula a expressão de receptores de estradiol (ER) e ocitocina (OXTR) no endométrio. A ativação de OXTR induz a ativação de uma complexa cascata que resulta na síntese de PGF2α. A hipótese é que o tratamento com 17β-E2, 15 dias após o estro (D15), modula a expressão gênica das proteínas quinase (PKC) e fosfolipase A2 (PLA2), ambas envolvidas na síntese de PGF2α e dependentes de cálcio. Objetivou-se neste estudo determinar os efeitos do 17β-E2 na abundância de trancritos (PKCα, PKCβ, PLA2G4, AKR1B1, AKR1

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9

Gyomorey, Sandor. "Temporal expression of prostaglandin endoperoxide H synthase type 2 and prostaglandin receptors at birth." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0023/MQ40864.pdf.

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10

Matthews, Jane Simone. "Characterisation of prostaglandin E receptors." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19997.

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Prostaglandin (PG) E<SUB>2</SUB> has been shown to act on at least three distinct receptor subtypes, designated EP<SUB>1</SUB>, EP<SUB>2</SUB> and EP<SUB>3</SUB>, with recent evidence suggesting the possibility of a fourth EP-receptor subtype. Whilst good antagonists are not available, a range of PGE analogues of differing selectivity for the three receptor subtypes may be used to determine which is effective in a given system. The activity of these analogues has not yet been assessed on the putative EP<SUB>4</SUB>-receptor containing preparation. This research has involved the use of such com

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11

Engblom, David. "Prostaglandin E₂ in immune-to-brain signaling /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med801s.pdf.

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12

Soontrapa, Kitipong. "Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression." Kyoto University, 2013. http://hdl.handle.net/2433/170077.

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13

Silva, Felipe Fortino Verdan da. "Prostaglandina E2 inibe a diferenciação de células Th17 no contexto de fagocitose de células apoptóticas infectadas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-07012016-154146/.

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A fagocitose de células apoptóticas, também denominada eferocitose, é um processo dinâmico e de fundamental importância para homeostase dos tecidos após uma injúria. Estudos demonstraram previamente que a fagocitose de células apoptóticas promove a síntese de mediadores anti-inflamatórios como PGE2, TGF-? e IL-10, podendo resultar num microambiente supressor e aumento da susceptibilidade do hospedeiro contra agentes infecciosos. Entretanto, a fagocitose de células apoptóticas infectadas por células dendríticas promove a geração não apenas de citocinas anti-inflamatórias como TGF-?, mas também

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14

Nascimento, Juliana. "Perfil do RNAm da proteína transportadora de prostaglandina (PGT) no endométrio equino in vivo e sobre influência embrionária in vitro." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-10102012-182843/.

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Nas éguas cíclicas, a luteólise ocorre entre os dias 14 e 16 após ovulação, pela ação da PGF2&#940 endometrial. Entretanto, durante a gestação, a luteólise deve ser bloqueada, ao mesmo passo que a ação da PGE2 deve ser estimulada. Ambos hormônios possuem baixa difusão pela membrana plasmática, sendo necessária a presença da proteína transportadora de prostaglandina (PGT) para o influxo e efluxo destes hormônios nas células. Os objetivos deste experimento foram identificar e relacionar o RNAm da PGT no endométrio de éguas cíclica e gestante aos 14 dias (experimento 1) e avaliar o perfil do RNAm

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15

Soares, Júlia Gleyci. "Estratégias para aumentar a recuperação de estruturas embrionárias de búfalas superovuladas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-16092015-111659/.

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Apesar de inúmeros estudos desenvolvidos no Brasil e no mundo, a utilização das biotecnologias de superovulação (SOV) e transferência de embriões (TE) em bubalinos ainda apresenta resultados inconsistentes, associados à principalmente à baixa taxa de recuperação de embriões. Dessa forma, o objetivo do presente estudo foi avaliar o efeito da utilização de dispositivo de P4 (para promover diminuição da contratilidade do trato genital, Capitulo 1) ou da administração de PGF2α (para promover aumento da atividade da fímbria e da frequência do batimento ciliar, Capítulo 2) durante o período per

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16

Fennekohl, Alexandra. "Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin-E2-Rezeptoren." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96491574X.

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17

Milling, Smith Oliver Patrick. "Prostaglandin signalling in the human endometrium." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/24983.

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This thesis is based on the hypothesis that menstrual dysfunction, including heavy menstrual blood loss (MBL) is due to (a) up-regulated expression/synthesis of cycloxygenase enzymes and prostaglandin receptors, and (b) initiation of enhanced intracellular signalling pathways in response to prostaglandins. This thesis describes the use of an endometrial epithelial cell line to explore the molecular signalling pathways involved with the activation of a prostaglandin receptor – the prostacyclin receptor. A rapid activation of ERK1/2 signalling is demonstrated with alterations in expression of an

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18

Norwitz, Errol R. "Prostaglandin production by human decidual cells." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314894.

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19

Alzamil, Hana Abdulrahman. "Localization of terminal prostaglandin synthases and prostaglandin transporter in human intrauterine tissues and the effect of pro-inflammatory cytokines on prostaglandin production at term and preterm labour." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526056.

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Silva, Júlio César Barboza da. "Utilização de FSH durante a sincronização da emergência da onda de crescimento folicular de doadoras submetidas à Ovum Pick Up, visando melhorar a produção in vitro de embriões." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-24032015-094737/.

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Biotecnologias como a Ovum Pick-Up e a Produção In vitro de embriões (OPU-PIVE) tem sido uma importante ferramenta para alcançar o melhoramento genético rápido nos rebanhos, diminuindo o intervalo entre gerações. No Brasil, a PIVE está em fase de crescimento e representa 70,7% de toda a produção in vitro mundial. Contudo a OPU-PIVE é ainda ineficiente em vacas de leite, especialmente devido à sua reduzida população folicular. Muitos estudos têm mostrado um efeito positivo do FSH em gado de leite e corte. Recentemente, a pré-estimulação com FSH mostrou ser capaz de aumentar o diâmetro dos folíc

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21

Kowalewski, Mariusz Paweł. "Untersuchungen zur Rolle des Prostaglandin Systems in der Regulation der Corpus Luteum Funktion der Hündin durch Erfassung der Expression von Cyclooxygenase 1 und -2 (Cox1,-2), Prostaglandin F2alpha Synthase (PGFS), Prostaglandin E2 Synthase (PGES) und Prostaglandin F2alpha Rezeptor (PGFR)." Lollar : Rosenbaum, 2007. http://geb.uni-giessen.de/geb/volltexte/2007/4476/index.html.

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Zarroug, Osman Hamza. "The roles of prostaglandin E2, prostaglandin F2α and aldo-keto reductase 1C isoenzymes in endometriosis and breast cancer". Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-roles-of-prostaglandin-e2-prostaglandin-f2alpha-and-aldoketo-reductase-1c-isoenzymes-in-endometriosis-and-breast-cancer(08db7cb3-7222-4513-b13b-cc3474c1ca2b).html.

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Endometriosis and breast cancer are sex hormone dependent diseases characterised by the local production of high levels of 17β-oestradiol. The relationship between prostaglandins and sex steroid hormones is one of the focal questions in endometriosis, breast cancer and other sex steroid hormone related disorders. Therefore, the main hypothesis was that the aldo-keto reductase (AKR) 1C isoenzymes are responsible for controlling the availability of 17β-oestradiol, progesterone and prostaglandins in the microenvironment of the endometrium, and surrounding adipose tissues of endometriotic lesions

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23

Wangpradit, Orarat. "Prostaglandin H synthase catalyzes the oxidation of 4-chlorobiphenyl metabolites, and the in vivo effects on prostaglandin production." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1101.

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Polychlorinated biphenyls (PCBs) exert a broad range of toxicity via both parent compounds and their metabolites. Our previous study showed that hydroquinone (H2Q) metabolites of PCBs act as cosubstrates for prostaglandin H synthase (PGHS), and are oxidized by this enzyme to corresponding quinones (Q). The goal of this thesis is to illuminate the PGHS-mediated toxicity of lower chlorinated PCBs. It is hypothesized that PGHS catalyzes two sequential one-electron oxidations of PCB-H2Q to semiquinone (SQ), and Q that interact with biomolecules, such as amino acids, glutathione (GSH), protein, and

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24

Elander, Louise. "Prostaglandin E₂ in brain-mediated illness responses /." Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53701.

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Elander, Louise. "Prostaglandin E2 in Brain-mediated Illness Responses." Doctoral thesis, Linköpings universitet, Cellbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53701.

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We are unceasingly exposed to potentially harmful microorganisms. The battle against threatening infectious agents includes activation of both the innate and of the adaptive immune systems. Illness responses are elicited and include inflammation, fever, decreased appetite, lethargy and increased sensitivity to painful stimuli in order to defeat invaders. While many of these signs of disease are controlled by the central nervous system, it has remained an enigma how signals from the peripheral immune system reach the brain through its blood-brain barrier, which precludes macromolecules, includi

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Karlsson, Sofia. "Studies of prostaglandin E2 formationin human monocytes." Licentiate thesis, Karlstads universitet, Avdelningen för kemi och biomedicinsk vetenskap, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4638.

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Prostaglandin (PG) E2 is an eicosanoid derived from the polyunsaturated twenty carbon fatty acid arachidonic acid (AA). PGE2 has physiological as well as pathophysiological functions and is known to be a key mediator of inflammatory responses. Formation of PGE2 is dependent upon the activities of three specific enzymes involved in the AA cascade; phospholipase A2 (PLA2), cyclooxygenase (COX) and PGE synthase (PGEs). Although the research within this field has been intense for decades, the regulatory mechanisms concerning the PGE2 synthesising enzymes are not completely established. PGE2 was in

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Li, Ding-You. "Ontogeny and regulation of cerebral prostaglandin receptors." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39944.

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The objective of this thesis was to test the hypothesis that the decreased effects of PGE$ sb2$ and PGF$ sb{2 alpha}$ on cerebral metabolism and vasculature in the newborn might result from a deficiency of brain EP and FP receptors, which may be downregulated by the relatively high brain levels of PGE$ sb2$ and PGF$ sb{2 alpha}.$<br>This study revealed that the densities of EP and FP receptors and receptor-coupled second messengers in brain synaptosomes and microvessels were much lower in the newborn than in the adult pigs, also the relative distribution of EP receptor subtypes in brain synapt

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Guyot, Thierry. "Stereoselective syntheses of allenes and prostaglandin derivatives." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367140.

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Haupt, Hayley Claire. "Strategies towards the synthesis of prostaglandin analogues." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/6312.

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Includes bibliographical references (leaves 173-179).<br>Different strategies for the synthesis of cyclopentenone prostaglandins and their analogues have been explored. The key transformation critical to the success of each of the described routes involves a Lewis-acid mediated retro Diels-Alder (rDA) reaction as the final step in liberating a 4, 5 disubstituted cyclopent-2-ene-1- one under extremely mild conditions. The first approach involves installation of the a-chain followed by base-mediated methodology to affect regiospecific enolate generation. Effective trapping of the enolate generat

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Inazumi, Tomoaki. "Roles of Prostaglandin EP4 Receptor in Adipocytes." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188727.

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Millard, Lindsey Highstrom. "Prostaglandin Involvement in the Conventional Outflow Pathway." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/145367.

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Prostaglandins (PG) play a major role in many endogenous processes including inflammation, labor, reproduction, and blood clotting. In the last two decades, these lipid signaling molecules have shown great potential as ocular hypotensive agents. Intraocular pressure (IOP) is a major risk factor in primary open-angled glaucoma (POAG), the second leading cause of blindness world-wide. Currently, prostaglandin F(2α) analogues are the most widely prescribed medications used to treat ocular hypertension. Studies have identified that almost all prostaglandin analogues exhibit anti-hypertensive effec

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Fong, Yew Su. "Cardiac contractile actions of prostaglandin F₂α". Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242532.

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Khidhir, Karzan Ghafur. "Regulation of hair growth : prostaglandins and prostamides : studies confirming the growth stimulating effects of prostanoids and prostamides on human hair follicles in organ culture and locating their receptors using lipidomics, molecular biological and immunohistological approaches." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5372.

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Hair growth disorders cause significant psychological distress, but are poorly controlled. Since prostaglandin F₂α (PGF₂α) and prostamide F₂α analogue glaucoma treatments cause eyelash growth as side-effects, they may be useful for alopecia. How they function is unknown; possibilities include direct action on hair follicles or stimulating follicular blood flow. It is important to clarify whether scalp follicles can also respond as human follicle response to androgens differ with body site. Therefore, human scalp follicles were grown in vitro in organ culture with PGF₂α, latanoprost, a PGF₂α an

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Carty, Elizabeth. "Thromboxanes and platelets in inflammatory bowel disease : pathogenic and therapeutic implications." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248411.

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Soares, Elyara Maria. "Avaliação da participação de mediadores lipídicos nas infecções experimentais induzidas por diferentes isolados de Mycobacterium tuberculosis de humanos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-21102013-115021/.

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Os mecanismos que conferem resistência do Mycobacterium tuberculosis (Mtb) à destruição pelo hospedeiro, além da sua capacidade em permanecer e/ou multiplicar-se no interior das células fagocitárias são ainda pouco compreendidos. Nosso grupo de pesquisa tem contribuído para o entendimento do papel dos mediadores lipídicos, que incluem prostaglandinas (PGs) e leucotrienos (LTs) na tuberculose. PGs inibem a resposta imune celular TH1, a produção de citocinas e a fagocitose, e assim facilita a infecção. LTs estão envolvidos no recrutamento de leucócitos, e na modulação da síntese de citocinas, no

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36

Plant, Matthew Hilton. "Characterization of a novel prostaglandin endoperoxide H synthase-1 transcript and examination of prostaglandin endoperoxide H synthase-1 expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/MQ46601.pdf.

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Simm, Björn [Verfasser]. "Zelluläre Wirkungen von Prostaglandin E2 und Prostaglandin D2 auf periphere und zentralnervöse Strukturen des Thermoregulationssystems der Ratte / Björn Simm." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1125345276/34.

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Kobayashi, Takuya. "Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptorsに関する研究". Kyoto University, 2000. http://hdl.handle.net/2433/151431.

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Grahl, Katrin. "Der Einfluss von Glykosaminoglykanen auf die Bildung und Freisetzung von Prostaglandin E2." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-187924.

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Diese Arbeit verdeutlicht die Wirkung von Chondroitinsulfat auf die Synthese von Prostaglandin E2 in humanen mesenchymalen Stromazellen in Abhängigkeit ihres Sulfatierungsgrades. MSC zeichnen sich durch ihre antiinflammatorischen Eigenschaften aus und haben damit einen modulierenden Effekt auf Wundheilungsprozesse. Als Vorläuferzellen von Osteoblasten sind sie direkt an der Knochenneubildung beteiligt. Eine persistierende Entzündung hat eine kontinuierliche Freisetzung von Zytokinen, wie IL-1 zur Folge. Es konnte gezeigt werden, dass IL-1 in hMSC zu einer Freisetzung von PGE2 führt. Unter kurz

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Pereira, Priscilla Aparecida Tartari. "Papel das prostaglandinas na infecção experimental por Histoplasma capsulatum." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-28112013-100514/.

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histoplasmose é uma doença granulomatosa crônica, cujo agente etiológico é o fungo dimórfico Histoplasma capsulatum. A infecção ocorre pela inalação de conídios ou pequenos fragmentos de micélio que alcançam os alvéolos, onde se transformam em leveduras que é responsável pela patogenia da doença. A imunidade celular do hospedeiro determina o grau das manifestações clínicas na histoplasmose, sendo a interação entre células T e macrófagos, fundamental para o controle da infecção e erradicação do H. capsulatum. Recentemente, nosso grupo de pesquisa demonstrou a participação de leucotrienos nos me

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Strohm, Daniela. "Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide." Phd thesis, Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2011/4967/.

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Die adipositasbedingte Insulinresistenz geht mit einer unterschwelligen Entzündungsreaktion einher. Als Antwort auf dieses Entzündungsgeschehen wird PGE2 unter anderem von Kupffer Zellen der Leber freigesetzt und kann seine Wirkung über vier PGE2-Rezeptorsubtypen (EP1-EP4) vermitteln. In vorangegangenen Arbeiten konnte gezeigt werden, dass PGE2 in Rattenhepatozyten über den EP3 R ERK1/2-abhängig die intrazelluläre Weiterleitung des Insulinsignals hemmt. Über die Modulation der Insulinrezeptorsignalkette durch andere EP-Rezeptoren war bisher nichts bekannt. Daher sollte in stabil transfizierten

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Martin, Rebecca Louise. "Regulation of prostaglandin production in the ovine placenta." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63196.pdf.

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Kwok, Ho-yan Amy, and 郭可茵. "Molecular cloning and characterization of chicken prostaglandin receptors." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508336.

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Matsuoka, Toshiyuki. "Prostaglandin D_2 as a mediator of allergic asthma." Kyoto University, 2000. http://hdl.handle.net/2433/180888.

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Kwok, Ho-yan Amy. "Molecular cloning and characterization of chicken prostaglandin receptors." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508336.

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Krause, Petra. "Effects of Prostaglandin E2 on Dendritic Cell functions." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-54682.

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Karlsson, Sofia. "Studies of prostaglandin E2 formation in human monocytes." Karlstad : Faculty of Technology and Science, Biomedical Sciences, Karlstads universitet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4638.

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Vijay, Rahul. "Prostaglandin regulation of immune responses against coronavirus infections." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3209.

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Prostaglandins (PG) are ubiquitous lipid mediators that play key roles in pathophysiological responses to infections. They are considered to have both pro and anti-inflammatory roles depending upon the time of inflammation, the receptors that they bind to and the tissues that they act upon. Hence given their pleiotropic effects, a perfect balance between the pro and anti-inflammatory functions of PGs are required to ensure that a controlled timely immune response is elicited to mediate protection and to avoid immunopathology. PGD2 is one such PG that was reported to increase with age in the lu

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Rizzoni, Leandro Becalete. "Aplicação do Cloprostenol Sódico em cabras leiteiras no puerpério." Universidade Jose do Rosario Vellano, 2012. http://tede2.unifenas.br:8080/jspui/handle/jspui/148.

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Made available in DSpace on 2016-05-02T13:55:51Z (GMT). No. of bitstreams: 1 LeandroBecaleteRizzoni-Dissertacao.pdf: 3096648 bytes, checksum: d5c52567fe33e15db0244070559133db (MD5) Previous issue date: 2012-04-18<br>This study assessed the of effects the application of cloprostenol in postpartum dairy goats. Twenty-nine Anglonubian goats were used, evenly divided into two groups. The control group received 0.5 ml of saline (0.9%) and group PGF2 0.133 mg cloprostenol in two intramuscular applications on day 1 (D1) and four (D4) PP. The reproductive tract of the animals was assessed by

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Koeberle, Andreas. "Identification and characterization of microsomal prostaglandin E₂ synthase-1 inhibitors = Identifizierung und Charakterisierung von Hemmstoffen der mikrosomalen Prostaglandin E₂ Synthase-1 /." Tübingen, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278394.

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