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Rozprawy doktorskie na temat „Protein association”

Autor: Grafiati

Data publikacji: 6 września 2023

Data aktualizacji: 26 lipca 2025

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1

Romero, Durana Miguel Alfonso. "Improving the description of protein-protein association energy." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/665466.

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Proteins play a crucial role in virtually every biological process taking place within our cells. Most of the times, proteins do not participate in these processes alone but forming complexes of two or more proteins. Therefore, the study of protein-protein interactions (PPIs) and complex formation has become an important field of research in the last decades due to its scientific relevance and therapeutic interest. Protein docking is one of the several computational approaches that have been applied to study protein interactions over the last years. It aims to determine the three-dimensional s

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2

Samuel, Jarvie John. "Elicitation of Protein-Protein Interactions from Biomedical Literature Using Association Rule Discovery." Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc30508/.

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Extracting information from a stack of data is a tedious task and the scenario is no different in proteomics. Volumes of research papers are published about study of various proteins in several species, their interactions with other proteins and identification of protein(s) as possible biomarker in causing diseases. It is a challenging task for biologists to keep track of these developments manually by reading through the literatures. Several tools have been developed by computer linguists to assist identification, extraction and hypotheses generation of proteins and protein-protein interactio

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3

Ahmad, Mazen [Verfasser], and Volkhard [Akademischer Betreuer] Helms. "Mechanisms of protein-protein association : atomistic molecular dynamics study of the association process / Mazen Ahmad. Betreuer: Volkhard Helms." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052551688/34.

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Donnini, S. (Serena). "Computing free energies of protein-ligand association." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285745.

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Abstract Spontaneous changes in protein systems, such as the binding of a ligand to an enzyme or receptor, are characterized by a decrease of free energy. Despite the recent developments in computing power and methodology, it remains challenging to accurately estimate free energy changes. Major issues are still concerned with the accuracy of the underlying model to describe the protein system and how well the calculation in fact emulates the behaviour of the system. This thesis is largely concerned with the quality of current free energy calculation methods as applied to protein-ligand system

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5

Doig, Andrew James. "Thermodynamics of peptide association and protein folding." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386389.

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6

Irudayam, Sheeba Jem. "Thermodynamics of Protein-Ligand Association and Hydration." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506575.

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7

Morrow, Robert Peter. "A study into human erythrocyte membrane protein association." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288406.

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8

Li, X. F. "Investigation of protein-protein interactions : multibody docking, association/dissociation kinetics and macromolecular crowding." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1302277/.

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Protein-protein interactions are central to understanding how cells carry out their wide array of functions and metabolic procedures. Conventional studies on specific protein interactions focus either on details of one-to-one binding interfaces, or on large networks that require a priori knowledge of binding strengths. Moreover, specific protein interactions, occurring within a crowded macromolecular environment, which is precisely the case for interactions in a real cell, are often under-investigated. A macromolecular simulation package, called BioSimz, has been developed to perform Langevin

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9

Huang, Wenhui. "Towards constructing disease relationship networks using genome-wide association studies." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/46326.

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Background: Genome-wide association studies (GWAS) prove to be a powerful approach to identify the genetic basis of various human[1] diseases. Here we take advantage of existing GWAS data and attempt to build a framework to understand the complex relationships among diseases. Specifically, we examined 49 diseases from all available GWAS with a cascade approach by exploiting network analysis to study the single nucleotide polymorphisms (SNP) effect on the similarity between different diseases. Proteins within perturbation subnetwork are considered to be connection points between the disease sim

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10

Jaeger, Samira. "Network-based inference of protein function and disease-gene association." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 2012. http://dx.doi.org/10.18452/16623.

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Proteininteraktionen sind entscheidend für zelluläre Funktion. Interaktionen reflektieren direkte funktionale Beziehungen zwischen Proteinen. Veränderungen in spezifischen Interaktionsmustern tragen zur Entstehung von Krankheiten bei. In dieser Arbeit werden funktionale und pathologische Aspekte von Proteininteraktionen analysiert, um Funktionen für bisher nicht charakterisierte Proteine vorherzusagen und Proteine mit Krankheitsphänotypen zu assoziieren. Verschiedene Methoden wurden in den letzten Jahren entwickelt, die die funktionalen Eigenschaften von Proteinen untersuchen. Dennoch bleibt

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11

Wang, Zhaoshuai. "ILLUMINATE THE PATHWAY OF MEMBRANE PROTEIN ASSOCIATION AND DEGRADATION." UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/87.

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Escherichia coli transporter protein AcrB and its homologues are the inner membrane components of the Resistance-Nodulation-Division (RND) family efflux pumps in Gram-negative bacteria. It is well accepted that soluble proteins are only marginally stable, but such insight is missing for membrane proteins. The lack of stability data, including thermodynamic stability and oligomer association affinity is a result of intrinsic difficulties in working with membrane proteins. In addition, the degradation of soluble proteins in E. coli has been extensively studied whereas the degradation process of

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12

Yalamanchili, Hari Krishna. "Computational approaches for protein functions and gene association networks." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206477.

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Entire molecular biology revolves primarily around proteins and genes (DNA and RNA). They collaborate with each other facilitating various biomolecular systems. Thus, to comprehend any biological phenomenon from very basic cell division to most complex cancer, it is fundamental to decode the functional dynamics of proteins and genes. Recently, computational approaches are being widely used to supplement traditional experimental approaches. However, each automated approach has its own advantages and limitations. In this thesis, major shortcomings of existing computational approaches are identif

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13

Vagedes, Peter. "Simulation of enzyme reactions the influence of protonation on catalysis and on protein protein association /." [S.l. : s.n.], 2001. http://www.diss.fu-berlin.de/2001/49/index.html.

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14

Taniguchi, Yoshihito. "LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein." Kyoto University, 1998. http://hdl.handle.net/2433/182239.

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15

Huffman, Jennifer Elizabeth. "Genetic analysis of protein N-glycosylation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10038.

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The majority of human proteins are post-translationally modified by covalent addition of one or more complex oligosaccharides (glycans). Alterations in glycosylation processing are associated with numerous diseases and glycans are attracting increasing attention both as disease biomarkers and as targets for novel therapeutic approaches. Using a recently developed high performance liquid chromatography (HPLC) method for high-throughput glycan analysis, genome-wide association studies (GWAS) of 33 directly measured and 13 derived N-glycan features were performed in 3533 individuals from four Eur

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16

Strout, Stephen Lewis. "Association between systemic lupus erythematosus and periodontitis." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004857.

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Thesis (M.S.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 43 pages. Includes Vita. Includes bibliographical references.

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17

Jacobs, Michael Graham. "Membrane association of dengue 2 virus non-structural protein 1." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325917.

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18

Deng, Yu. "Regulation of mammalian STE20-like kinase (MST2) by phosphorylation/dephosphorylation, proteolysis and association with HSP90 during apoptosis /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20DENG.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 148-164). Also available in electronic version. Access restricted to campus users.

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19

Kemper, Courtney Paige. "Association Among Physical Activity, Protein, Intake and Clinical Indicators of Sarcopenia." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1605816952601922.

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20

Kidd, Kameha Rae. "Angiogenesis and neovascularization in association with extracellular matrix protein modified biomaterials." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/279992.

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Synthetic biomedical implants are used to replace diseased tissues and organs. Unfortunately, these implants often fail due to a lack of biocompatibility and poor integration by the recipient. This implant failure is associated with the formation of an avascular fibrous capsule and chronic inflammatory response. Additionally, small diameter vascular grafts have complications associated with surface thrombogenenicity and intimal hyperplasia. Porous polymers are often incorporated in the construction of biomedical devices because they permit tissue integration and improved biocompatibility. Whil

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21

Foster, Andrew. "Development of a novel two-hybrid system for the identification of cyclic peptide induced protein-protein association." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/418010/.

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Chemically-induced protein association is involved in key regulatory pathways throughout the body. Many natural products exert their downstream effect by the stabilisation of naturally occurring interactions, either by an allosteric effect or by the direct binding of two distinct protein partners. The targeting of these interactions by small-molecules is a relatively under developed field, with the inhibition of existing protein-protein interactions (PPIs) a more investigated target. One such method to investigate PPI inhibition is a bacterial reverse two-hybrid system (RTHS), which has been s

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22

Panova, Stanislava. "NMR approaches to understanding intramolecular and intermolecular interactions in proteins." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/nmr-approaches-to-understanding-intramolecular-and-intermolecular-interactions-in-proteins(95a44c16-fd44-4909-8ee2-435f574d2970).html.

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Inhibition of the intrinsically disordered proteins (IDP) is a recognized issue in drug research. Standard approaches, based on key-lock model, cannot be used in the absence of rigid structure and defined active site. Here a basic helix-loop-helix leucine zipper (bHLHZip) domain of c-Myc was studied, which is intrinsically disordered and prone to aggregation. Chemical denaturation of proteins is a widely accepted technique to study protein folding, but here this methodology was applied to IDP, observing its effect on the structural ensemble of c-Myc by NMR spectroscopy. Nonlinear chemical shif

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23

Ozer, Hatice Gulcin. "Residue Associations In Protein Family Alignments." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211570026.

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24

Cai, Jingfei. "Probing the Membrane Association Mechanisms for Pulmonary Collectins and Mammalian Phospholipase C." Thesis, Boston College, 2013. http://hdl.handle.net/2345/3872.

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Thesis advisor: Mary F. Roberts<br>Thesis advisor: Eranthie Weerapana<br>Peripheral proteins from mammals often exhibit multi-domain structures and require metal ions such as calcium as co-factors. This dissertation investigates two types of such proteins -- pulmonary collectins (surfactant proteins A and D) and phosphatidylinositol-specific phospholipase C (PLC) delta1 -- and their interactions with model membranes. One approach to work around the complexity brought upon by such multi-domain protein structure is to use a truncated construct or an isolated single domain. For pulmonary collecti

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25

Hill, Stephanie. "Folding and association of spectrin tetramer domains : a study of intrinsically disordered proteins from a protein folding perspective." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648579.

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26

Cromwell, Mary Ellen Miley. "Self-association, crystallization, and phase separation : understanding intermolecular interactions for a monoclonal antibody /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Pharmaceutical Sciences) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 209-236). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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27

Martínez, Barrio Álvaro. "Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies." Uppsala : Acta Universitatis Upsaliensis, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111932.

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Martínez, Barrio Álvaro. "Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies." Doctoral thesis, Uppsala universitet, Centrum för bioinformatik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111932.

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Recently, the pace of growth in the amount of data sources within Life Sciences has increased exponentially until pose a difficult problem to efficiently manage their integration. The data avalanche we are experiencing may be significant for a turning point in science, with a change of orientation from proprietary to publicly available data and a concomitant acceptance of studies based on the latter. To investigate these issues, a Network of Excellence (EMBRACE) was launched with the aim to integrate the major databases and the most popular bioinformatics software tools. The focus of this thes

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29

di, Bard Barbara Lelj Garolla. "Self-association and chaperon activity of the small heat shock protein 27." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31382.

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Human Hsp27 is a member of the small heat shock protein family that is over-expressed during cellular stress and that is involved in biological functions ranging from inhibition of apoptosis to regulation of cellular glutathione levels. In addition, Hsp27 is an ATP-independent molecular chaperon that binds to unfolding peptides and inhibits their precipitation. Roles for Hsp27 in several human diseases have also been proposed. For example, the expression of Hsp27 by several human tumors has been noted as a potential diagnostic feature or a therapeutic target. Increasing evidence indicates that

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30

Naji, Hassan Salim. "Association of Bisphenol A and C-Reactive Protein Concentrations with Cardiovascular Diseases." ScholarWorks, 2015. http://scholarworks.waldenu.edu/dissertations/1707.

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Bisphenol A (BPA), a widely used chemical in plastic, has drawn wide attention due to its presence in many consumer products and the environment. The purpose of this study was to examine the association between urinary BPA and the reporting of cardiovascular diseases (CVD), and then to examine the effect of C-reactive protein (CRP) as a moderating variable. The data used in this research were extracted from the National Health and Nutrition Examination Survey collected in 2009-2010. Guided by the advanced epidemiological triangle, analysis involved 2 stepwise binary logistic regressions. The f

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31

Lawton, Edward. "Self association and transcription activation determinants in a bacterial enhancer binding protein." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29205.

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Bacterial transcription initiation relies on the binding of a dissociable sigma factor to the catalytic RNA polymerase (RNAP) 'core' enzyme to enable promoter specific DNA recognition. While the initial σ70 RNAP-promoter DNA bound complex (termed the closed complex) can spontaneously isomerise to form open promoter complexes, RNAP containing the major variant, the σ54 factor requires activation by bacterial enhancer binding proteins (bEBPs) which reorganize the initial closed promoter complex to an open complex in an ATP consuming reaction. These bEBPs belong to the AAA+ (ATPases associated wi

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32

Hallén, Elin. "Coagulation properties of milk : association with milk protein composition and genetic polymorphism /." Uppsala : Department of Food Science, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200875.pdf.

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Atway, Nader G. "The Association of Cell Cycle and Growth Related Protein Kinases with the Fibroblast Cytoskeleton." Connect to online version at Digital.Maag Connect to online version at OhioLINK ETD, 1999. http://hdl.handle.net/1989/4814.

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34

Meng, Hai Yun. "Determinants of cis-trans isomerism of the aromatic-prolyl amide bond and design of lathanide-binding peptides." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 2.04 Mb., 133 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1432291.

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35

Costanzi, Elisa. "Structural analysis of molecular recognition and ligand association processes." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3421838.

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Molecular recognition is a fundamental step in essentially any biochemical process. Detailed structural knowledge is crucial to have a better understanding of the processes in which the two interacting molecular partners are involved and can be exploited in several applied fields such as supramolecular design of new molecular assemblies, rational drug design, and enzyme engineering. In the context of molecular recognition, I have investigated (mainly by single crystal x-ray crystallography) some relevant protein-protein and protein-ligand systems in order to gain detailed structural insights

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36

Perschbacher, Katherine. "Regulator of G Protein Signaling 2 (RGS2) in preeclampsia: association, consequence, and cause." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6621.

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Increased signaling of various hormones through their cognate G Protein-Coupled Receptors (GPCRs), including the angiotensin, endothelin, and vasopressin systems, are implicated in human preeclampsia (PreE) and animal models of the disorder. Cascade-specific termination of GPCR signaling following receptor activation is catalyzed by the Regulator of G protein Signaling (RGS) family members. Within the RGS B/R4 family, RGS5 and RGS2 are implicated in human PreE and gestational hypertensive disorders. Mutations within the RGS2 gene, a B/R4 RGS member, are associated with human hypertensive popul

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37

Köster, Liza Sally. "C-reactive protein in canine babesiosis caused by Babesia rossi and its association with outcome." Pretoria : [s.n.], 2010. http://upetd.up.ac.za/thesis/available/etd-02262010-140236/.

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38

Chen, Bernard. "Discovery and Extraction of Protein Sequence Motif Information that Transcends Protein Family Boundaries." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/cs_diss/42.

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Protein sequence motifs are gathering more and more attention in the field of sequence analysis. The recurring patterns have the potential to determine the conformation, function and activities of the proteins. In our work, we obtained protein sequence motifs which are universally conserved across protein family boundaries. Therefore, unlike most popular motif discovering algorithms, our input dataset is extremely large. As a result, an efficient technique is essential. We use two granular computing models, Fuzzy Improved K-means (FIK) and Fuzzy Greedy K-means (FGK), in order to efficient

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39

Ragheb, Amro M. Brook Michael A. "Controlling protein-silicone interactions by the modification of silicone elastomers with poly(ethylene oxide) /." *McMaster only, 2005.

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40

Ahmadi-Abhari, Sara. "Epidemiology of C-reactive protein in the older adult population : distribution, determinants, and association with health outcomes." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709155.

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41

Ostermeir, Katja [Verfasser], Martin [Akademischer Betreuer] Zacharias, Iris [Akademischer Betreuer] Antes, and Ulrich [Akademischer Betreuer] Gerland. "Advanced sampling to study protein plasticity and protein association / Katja Ostermeir. Gutachter: Martin Zacharias ; Iris Antes ; Ulrich Gerland. Betreuer: Martin Zacharias." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1061126188/34.

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42

Vilaprinyó, Pascual Sílvia. "The dynamic nature of amyloid-beta protein aggregation and its association to Alzheimer’s disease." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/305364.

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Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant processing of Aß that determines its accumulation and aggregation into large oligomer species that evolve into the fibrillar structures deposited in amyloid plaques in the brain of AD patients. The neurotoxicity observed in AD has been attributed to the oligomeric intermediates, although their stoichiometry and structure still remain unknown. This is the reason why no AD therapeutic approaches

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Barnett, Catherine Margaret Eleanor. "Association of Single Nucleotide Polymorphisms in Surfactant Protein A and D with Otitis Media." The University of Waikato, 2007. http://hdl.handle.net/10289/2338.

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Otitis Media is one of the most common childhood diseases. Recurrent acute otitis media RAOM is characterized by repeated episodes of inflammation of the middle ear in conjunction with middle ear fluid, and often with an inflamed or bulging eardrum. Defective clearance by the Eustachian tube results in mucus build-up and is characteristic of otitis media with effusion (OME). Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, respiratory syncytial virus, and rhinovirus are the most common contributors to otitis media pathogenesis. In New Zealand, OME has been implicated wi

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44

Dunne, P. D. "Association and segregation : fluorescence studies of protein organisation in the membranes of living cells." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598700.

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This thesis details efforts to develop and adapt fluorescence microscopy techniques for the study of membrane protein association and segregation in live cells, both within membranes and between different membranes. After an initial introduction to the cell membrane and fluorescence microscopy, the experimental section of this thesis is split into two parts. Part A concerns the development of techniques to explore the unresolved triggering mechanism through which T-cells, a cell of the adaptive immune system, first recognise threats. After a brief introduction to T-cell biology, association of

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45

Van, Niekerk Michelle. "Association of nonstructural protein NS3 of African horsesickness virus with cytotoxicity and virus virulence." Thesis, University of Pretoria, 2002. http://hdl.handle.net/2263/29951.

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Factors that determine the molecular basis of African horsesickness virus (AHSV) virulence are unclear. Several proteins and different events in the viral replication cycle together with different environmental factors are likely to contribute to the virulence phenotype. The aim of this investigation was to study the possible contribution of AHSV nonstructural protein NS3 to virus virulence. NS3 is a cytotoxic protein that localizes in areas of plasma membrane disruption and is assumed to be associated with the release of virus particles from infected cells. A conserved feature in all AHSV NS3

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46

Martinez, Jessica A., Betsy C. Wertheim, Cynthia A. Thomson, et al. "Physical Activity Modifies the Association between Dietary Protein and Lean Mass of Postmenopausal Women." ELSEVIER SCIENCE INC, 2017. http://hdl.handle.net/10150/623078.

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Background Maintenance of lean muscle mass and related strength is associated with lower risk for numerous chronic diseases of aging in women. Objective Our aim was to evaluate whether the association between dietary protein and lean mass differs by physical activity level, amino acid composition, and body mass index categories. Design We performed a cross-sectional analysis of a prospective cohort. Participants/setting Participants were postmenopausal women from the Womens Health Initiative with body composition measurements by dual-energy x-ray absorptiometry (n=8,298). Main outcome measures

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47

Carnio, Leanne Katherine. "Direct association of integrin-linked kinase with a novel calponin homology domain-containing protein, CLINT." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0022/MQ50412.pdf.

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48

Lilja, Sandra. "The association of the genes HvNAM1 and HvNAM2 with grain protein content in Nordic barley." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119194.

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In barley, the GPC (Grain Protein Content) has proved to be of great importance for both feed, food and beer production. When it comes to feed and food, a high GPC is desirable since it indicates good nutritional values, while in beer production a low and stable GPC is needed to avoid beer chill haze. In previous studies a decrease in the GPC has been seen in different accessions of barley developed at different time periods during the last 100 years. The gene family HvNAM, including the genes HvNAM1 and HvNAM2, has in previous studies been shown to be important for the remobilization of nutri

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Koster, Liza Sally. "C-reactive protein in canine babesiosis caused by Babesia rossi and its association with outcome." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/22860.

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Acute phase proteins (APP) are ideal biomarkers for inflammation due to their stability, relative ease of assay and apparent relation between their concentration and the extent of the insult to tissue. C-reactive protein (CRP) is a positive major APP in dogs and can be used as a predictive marker for risk of disease and to monitor the response to treatment. Increased concentrations in certain diseases are associated with poor outcome. This cross-sectional, observational study of 75 dogs naturally infected with Babesia rossi, a cause of virulent canine babesiosis, was designed to examine the as

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Zhang, Yifeng. "Association of Protein Disulfide Isomerase and ATP Synthase β Subunit with Membrane-Bound P-Glycoprotein". Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/322110.

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