Gotowe bibliografie tematyczne / Protein Based Molecular Diseases

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Gotowa bibliografia na temat „Protein Based Molecular Diseases”

Autor: Grafiati

Data publikacji: 7 września 2023

Data aktualizacji: 31 lipca 2025

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Artykuły w czasopismach na temat "Protein Based Molecular Diseases"

Li, Yan, Yi Jia, Xiao-Lin Wang, Hai Shang, and Yu Tian. "Protein-Targeted Degradation Agents Based on Natural Products." Pharmaceuticals 16, no. 1 (2022): 46. http://dx.doi.org/10.3390/ph16010046.

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Natural products are an important source of drug lead compounds, and natural products with significant biological activity are constantly being discovered and used in clinical practice. At present, natural products play an important role in the targeted therapy of cancer, cardiovascular and cerebrovascular diseases, nervous system diseases, and autoimmune diseases. Meanwhile, in recent years, the rise of protein-targeted degradation technologies, such as proteolysis-targeting chimeras (PROTACs) and molecular glues, has provided a new solution for drug resistance caused by clinical molecular-ta

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Telling, Glenn. "Protein-based PCR for prion diseases?" Nature Medicine 7, no. 7 (2001): 778–79. http://dx.doi.org/10.1038/89895.

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Yadav, Kusum, Anurag Yadav, Priyanka Vashistha, Veda P. Pandey, and Upendra N. Dwivedi. "Protein Misfolding Diseases and Therapeutic Approaches." Current Protein & Peptide Science 20, no. 12 (2019): 1226–45. http://dx.doi.org/10.2174/1389203720666190610092840.

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Protein folding is the process by which a polypeptide chain acquires its functional, native 3D structure. Protein misfolding, on the other hand, is a process in which protein fails to fold into its native functional conformation. This misfolding of proteins may lead to precipitation of a number of serious diseases such as Cystic Fibrosis (CF), Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and Amyotrophic Lateral Sclerosis (ALS) etc. Protein Quality-control (PQC) systems, consisting of molecular chaperones, proteases and regulatory factors, help in protein folding and prevent its aggregat

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Teribele Venturin, Gianina, and Zhen Cheng. "Small Peptide and Protein-based Molecular Probes for Imaging Neurological Diseases." Current Protein & Peptide Science 17, no. 6 (2016): 543–58. http://dx.doi.org/10.2174/1389203717666160101123500.

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Lorenzo-Pouso, Alejandro I., Mario Pérez-Sayáns, Susana B. Bravo, et al. "Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases." Disease Markers 2018 (November 7, 2018): 1–22. http://dx.doi.org/10.1155/2018/6141845.

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The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and acce

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Pang, Yihe, and Bin Liu. "DMFpred: Predicting protein disorder molecular functions based on protein cubic language model." PLOS Computational Biology 18, no. 10 (2022): e1010668. http://dx.doi.org/10.1371/journal.pcbi.1010668.

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Intrinsically disordered proteins and regions (IDP/IDRs) are widespread in living organisms and perform various essential molecular functions. These functions are summarized as six general categories, including entropic chain, assembler, scavenger, effector, display site, and chaperone. The alteration of IDP functions is responsible for many human diseases. Therefore, identifying the function of disordered proteins is helpful for the studies of drug target discovery and rational drug design. Experimental identification of the molecular functions of IDP in the wet lab is an expensive and labori

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Kovacs, Gabor G. "Molecular pathology of neurodegenerative diseases: principles and practice." Journal of Clinical Pathology 72, no. 11 (2019): 725–35. http://dx.doi.org/10.1136/jclinpath-2019-205952.

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Neurodegenerative diseases are characterised by selective dysfunction and progressive loss of synapses and neurons associated with pathologically altered proteins that deposit primarily in the human brain and spinal cord. Recent discoveries have identified a spectrum of distinct immunohistochemically and biochemically detectable proteins, which serve as a basis for protein-based disease classification. Diagnostic criteria have been updated and disease staging procedures have been proposed. These are based on novel concepts which recognise that (1) most of these proteins follow a sequential dis

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Chaudhuri, Tapan K., and Subhankar Paul. "Protein-misfolding diseases and chaperone-based therapeutic approaches." FEBS Journal 273, no. 7 (2006): 1331–49. http://dx.doi.org/10.1111/j.1742-4658.2006.05181.x.

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Mishra and Dey. "Molecular Docking Studies of a Cyclic Octapeptide-Cyclosaplin from Sandalwood." Biomolecules 9, no. 11 (2019): 740. http://dx.doi.org/10.3390/biom9110740.

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Natural products from plants, such as chemopreventive agents, attract huge attention because of their low toxicity and high specificity. The rational drug design in combination with structure-based modeling and rapid screening methods offer significant potential for identifying and developing lead anticancer molecules. Thus, the molecular docking method plays an important role in screening a large set of molecules based on their free binding energies and proposes structural hypotheses of how the molecules can inhibit the target. Several peptide-based therapeutics have been developed to combat

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Gul, Irfan, Amreena Hassan, Ehtishamul Haq, et al. "An Investigation of the Antiviral Potential of Phytocompounds against Avian Infectious Bronchitis Virus through Template-Based Molecular Docking and Molecular Dynamics Simulation Analysis." Viruses 15, no. 4 (2023): 847. http://dx.doi.org/10.3390/v15040847.

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Vaccination is widely used to control Infectious Bronchitis in poultry; however, the limited cross-protection and safety issues associated with these vaccines can lead to vaccination failures. Keeping these limitations in mind, the current study explored the antiviral potential of phytocompounds against the Infectious Bronchitis virus using in silico approaches. A total of 1300 phytocompounds derived from fourteen botanicals were screened for their potential ability to inhibit the main protease, papain-like protease or RNA-dependent RNA–polymerase of the virus. The study identified Methyl Rosm

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Rozprawy doktorskie na temat "Protein Based Molecular Diseases"

Kumari, Vandana. "Structure-Based Computer Aided Drug Design and Analysis for Different Disease Targets." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1311612599.

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Dickerson, Matthew Thomas. "PROTEIN BASED BIOMIMETIC APPROACHS TO SURFACE HEMOCOMPATIBILITY AND BIOCOMPATIBILITY ENHANCEMENT." UKnowledge, 2012. http://uknowledge.uky.edu/cme_etds/6.

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T. pallidum can survive a primary immune response and continue growing in the host for an extended period of time. T. pallidum is thought to bind serum fibronectin (FN) through Tp0483 on the surface to obscure antigens. A Tp0483 fragment (rTp0483) was adsorbed onto functionalized self-assembled monolayers (SAMs) with FN. FN capture by adsorbed rTp0483 depended greatly on surface chemistry with COO- groups being best for FN binding. Hemocompatibility was determined by analysis of plasma protein adsorption, intrinsic pathway activation, and platelet activation. rTp0483+FN bound an equal or lesse

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Drobin, Kimi. "Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum." Licentiate thesis, KTH, Proteinvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-225980.

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Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. A highly multiplexed antibody-based suspension bead array is created by coupling antibodies generated in the Human Protein Atlas project to color-coded beads. The beads are combined for parallel analysis of up to 384 analytes in patient and control samples. This provides data to compare protein levels from the different groups. In paper I osteoporosis patients are compa

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Liu, Jiyun. "Structure based design of inhibitors toward disease related multivalent protein targets /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8482.

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Freer, Rosie. "Molecular origins of tissue vulnerability to aberrant aggregation in protein misfolding diseases." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275420.

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Neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are increasingly common in our ageing society, are remain incurable. A major obstacle encountered by researchers in their attempts to find effective therapies is represented by the current lack of understanding of the molecular origins of these disorders. It is becoming clear that, although the aggregation of specific proteins, including amyloid β (Aβ) and tau in AD and α-synuclein in PD, hallmark these disorders, such behaviour is a consequence of a wider, system-level disruption of protein homeostas

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Lewandowski, Eric Michael. "Structure Based Drug Design Targeting Bacterial Antibiotic Resistance and Alzheimer's Disease." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5982.

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Structure based drug design is a rapidly advancing discipline that examines how protein targets structurally interact with small molecules, or known inhibitors, and then uses this information to lead inhibitor optimization efforts. In the case of novel inhibitors, protein structural information is first obtained via X-ray crystallography, NMR studies, or a combination of both approaches. Then, computational molecular docking is often used to screen, in silico, millions of small molecules and calculate the potential interactions they may have with the target protein’s binding pocket, in hopes o

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Hilbert, Brendan J. "Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/681.

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Transcriptional regulatory complexes control gene expression patterns and permit cellular responses to stimuli. Deregulation of complex components upsets target gene expression and can lead to disease. This dissertation examines proteins involved in two distinct regulatory complexes: C-terminal binding protein (CtBP) 1 and 2, and Interferon Regulatory Factors (IRF) 3 and 5. Although critical in developmental processes and injury response, CtBP transcriptional repression of cell adhesion proteins, pro-apoptotic factors, and tumor suppressors has been linked to the pathogenesis of multiple forms

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Hilbert, Brendan J. "Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/681.

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Lau, Kin-chong, and 劉健莊. "Microarray-based investigations of genetic diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45894760.

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Hall, David. "An XML-based Database of Molecular Pathways." Thesis, Linköping University, Department of Computer and Information Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-3717.

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<p>Research of protein-protein interactions produce vast quantities of data and there exists a large number of databases with data from this research. Many of these databases offers the data for download on the web in a number of different formats, many of them XML-based.</p><p>With the arrival of these XML-based formats, and especially the standardized formats such as PSI-MI, SBML and BioPAX, there is a need for searching in data represented in XML. We wanted to investigate the capabilities of XML query tools when it comes to searching in this data. Due to the large datasets we concentrated o

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Książki na temat "Protein Based Molecular Diseases"

Henrik, Bohr, and Brunak Søren, eds. Protein folds: A distance-based approach. CRC Press, 1996.

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Coleman, Thomas F. Parallel continuation-based global optimization for molecular conformation and protein folding. Cornell Theory Center, Cornell University, 1994.

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Crichton, Robert R. Metal-based neurodegeneration: From molecular mechanisms to therapeutic strategies. 2nd ed. John Wiley & Sons, 2013.

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Schwarz, Siegfried. Molecules of life & mutations: Understanding diseases by understanding proteins. Karger, 2002.

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Schwarz, Siegfried. Molecules of life & mutations: Understanding diseases by understanding proteins. Karger, 2002.

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Xu, Jiru. Application of PCR and DNA sequencing based molecular diagnosis in infectious diseases. The Author], 2003.

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Macario, Alberto J. L. The chaperonopathies: Diseases with defective molecular chaperones : an introduction and guide to diseases in which chaperones play an etiologic-pathogenic role. Springer, 2013.

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Expert Workshop on DNA-Based Molecular Diagnostic Techniques : Research Needs for Standardization and Validation of the Detection of Aquatic Animal Pathogens and Diseases (1999 Bangkok, Thailand). DNA-based molecular diagnostic techniques: Research needs for standardization and validation of the detection of aquatic animal pathogens and diseases. Food and Agriculture Organization of the United Nations, 2000.

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1942-, Garland John M., Quesenberry Peter J, and Hilton Douglas J. 1964-, eds. Colony-stimulating factors: Molecular and cellular biology. 2nd ed. M. Dekker, 1997.

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Jon, Lorsch, ed. Translation initiation: Cell biology, high-throughput methods, and chemical-based approaches. Academic Press, 2007.

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Części książek na temat "Protein Based Molecular Diseases"

Herrero-Hernandez, Pablo, Atze J. Bergsma, and W. W. M. Pim Pijnappel. "Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_15.

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AbstractAlternative pre-mRNAsplicing can be cell-type specific and results in the generation of different protein isoforms from a single gene. Deregulation of canonical pre-mRNAsplicing by disease-associated variants can result in genetic disorders. Antisense oligonucleotides (AONs) offer an attractive solution to modulate endogenous gene expression through alteration of pre-mRNAsplicing events. Relevant in vitro models are crucial for appropriate evaluation of splicing modifying drugs. In this chapter, we describe how to investigate the splicing modulating activity of AONs in an in vitro skel

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Davtyan, Hayk, Irina Petrushina, and Anahit Ghochikyan. "Immunotherapy for Alzheimer’s Disease: DNA- and Protein-Based Epitope Vaccines." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0410-5_16.

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Wang, Hong, and Samir Hanash. "Intact-Protein Analysis System for Discovery of Serum-Based Disease Biomarkers." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-068-3_4.

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Dutta, Naibedya, Suvranil Ghosh, and Mahadeb Pal. "Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin." In Evidence Based Validation of Traditional Medicines. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8127-4_5.

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Suárez-Herrera, Nuria, Tomasz Z. Tomkiewicz, Alejandro Garanto, and Rob W. J. Collin. "Development and Use of Cellular Systems to Assess and Correct Splicing Defects." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_9.

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AbstractA significant proportion of mutations underlying genetic disorders affect pre-mRNA splicing, generally causing partial or total skipping of exons, and/or inclusion of pseudoexons. These changes often lead to the formation of aberrant transcripts that can induce nonsense-mediated decay, and a subsequent lack of functional protein. For some genetic disorders, including inherited retinal diseases (IRDs), reproducing splicing dynamics in vitro is a challenge due to the specific environment provided by, e.g. the retinal tissue, cells of which cannot be easily obtained and/or cultured. Here,

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Yan, Bin, Panwen Wang, Junwen Wang, and Kenneth R. Boheler. "Discovery of Surface Target Proteins Linking Drugs, Molecular Markers, Gene Regulation, Protein Networks, and Disease by Using a Web-Based Platform Targets-search." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7553-2_19.

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Chakraborty, Kausik, Florian Georgescauld, Manajit Hayer-Hartl, and F. Ulrich Hartl. "Role of Molecular Chaperones in Protein Folding." In Protein Misfolding Diseases. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470572702.ch3.

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Tessier, Peter M., and Susan Lindquist. "Unraveling Molecular Mechanisms and Structures of Self-Perpetuating Prions." In Protein Misfolding Diseases. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470572702.ch8.

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Solís-Fernández, Guillermo, Ana Montero-Calle, Miren Alonso-Navarro, et al. "Protein Microarrays for Ocular Diseases." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1562-1_17.

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Esposito, Gennaro, and Vittorio Bellotti. "Emerging Molecular Targets in the Therapy of Dialysis-Related Amyloidosis." In Protein Misfolding Diseases. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470572702.ch38.

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Streszczenia konferencji na temat "Protein Based Molecular Diseases"

Konc, Janez, and Dušanka Janežič. "Algorithms and web servers for protein binding sites detection in drug discovery." In 2nd International Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.014k.

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Drug discovery is a protracted and demanding process, which can be expedited during its early stages through novel mathematical approaches and modern computing. To tackle this crucial issue, we are developing fresh mathematical solutions aimed at detecting and characterizing protein binding sites, pivotal for new drug discovery. This paper introduces algorithms founded on graph theory which we have devised to scrutinize target biological proteins. These algorithms yield vital data, facilitating the optimization of initial phases in novel drug development. A particular emphasis lies in the crea

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Sodnomov, T. C., and I. A. Kutyrev. "STUDY ON POTENTIAL IMMUNOREGULATORY PROTEINS IN THE EXCRETORY-SECRETORY PRODUCTS OF CESTODES." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2024. http://dx.doi.org/10.31016/978-5-6050437-8-2.2024.25.388-393.

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This article studied excretory-secretory products of parasitic flatworms aimed at searching for potential immunoregulatory proteins. Immunoregulatory proteins are poorly studied at the moment. Recent years have showed increased interest in identifying immunoregulatory molecules produced by parasitic worms. Potential immunoregulatory proteins will make a significant contribution to the development of medicine and biotechnology and will make it possible to effectively treat allergic and other autoimmune diseases. The study used methods of bioinformatics, proteomics, and transcriptomics. Potentia

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Faria, Gustavo Hugo de Souza. "The impact of epigenetics on the development of neurodegenerative diseases." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.654.

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Introduction: Neurodegenerative diseases affect thousands of people in Brazil and have been increasing in frequency with the aging population. However, little is known about the molecular mechanisms and biomarkers of these diseases, which leads to a medical approach based on symptomatic and unresolving characteristics. Epigenetics, including DNA methylation, histone modifications, and changes in regulatory RNAs, emerges as a tool for prevention of neurodegenerative diseases. Objectives: To review studies that discuss the role of epigenetics in the development of neurodegenerative diseases. Met

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Wijeratne, Shalini. "A Comparative Analysis of Nanoluc Luciferase and Alkaline Phosphatase as Reporter Proteins for Phage-based Pathogen Detection." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/iibu6123.

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Rapid and specific detection of pathogenic bacteria in food and water sources can be crucial to disease diagnosis and prevention. Genetically modified bacteriophage-based assays are a promising alternative over standard overnight culture-based assays as they can provide comparatively rapid detection. Bacteriophage (phage) viruses specifically infect live bacterial cells for the rapid replication of their viral genome. Scientists exploit this in-built molecular amplification system by genetically modifying phage genes to express certain reporter proteins during an infection. The expression of r

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Uzel, Sebastien, and Markus J. Buehler. "Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13160.

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Collagen is a crucial structural protein material, formed through a hierarchical assembly of tropocollagen molecules, arranged in collagen fibrils that constitute the basis for larger-scale fibrils and fibers. Osteogenesis imperfecta is a genetic disorder in collagen characterized by mechanically weakened tendon, fragile bones, skeletal deformities and in severe cases prenatal death. Even though many studies have attempted to associate specific mutation types with phenotypic severity, the mechanisms by which a single point mutation influences the mechanical behavior of tissues at multiple leng

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Rubani, Muhammad, and Arli Aditya Parikesit. "Molecular Simulation of Coffee Beans’ Natural Products as Lead Compounds for Stroke Remedy." In The 6th International Conference on Science and Engineering. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-k5delo.

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The consumption of coffee has its health benefits and its risks, one of the risks is mostly related to cardiovascular diseases. One of the diseases is hypertension which is considered “the silent killer” as it is a serious condition which promotes other complications and typically has no symptoms for a period of time until it has done significant damage. Acute hypertension can lead to a stroke. It is a very serious medical condition where the blood flow to the brain is poor, causing the death of cells within the brain. Some medications, surgeries and other healthcare programs are capable of co

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Bent, Andrew. "Molecular characterization of Rhg1 alpha-SNAP in SCN disease resistance in soybean." In IS-MPMI Congress. IS-MPMI, 2023. http://dx.doi.org/10.1094/ismpmi-2023-4.

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Soybean cyst nematode (SCN) is the most yield-reducing pathogen of soybean. Resistance based on the complex rhg1-b haplotype has been the primary control measure, but gradual SCN evolution is incrementally eroding rhg1-b efficacy. rhg1-b carries ten copies of a ~31 kb chromosomal segment with three different genes that contribute to resistance. We are functionally dissecting the rhg1-b α-SNAP to understand and possibly improve this novel defense mechanism. α-SNAP is a housekeeping protein with C-terminal amino acids that are conserved across multicellular eukaryotes. a-SNAP interacts with NSF

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"Molecular characterization of Rhg1 alpha-SNAP in SCN disease resistance in soybean." In IS-MPMI Congress. IS-MPMI, 2023. http://dx.doi.org/10.1094/ismpmi-2023-4r.

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Коробкова, В. А., А. Г. Черноок, М. Г. Дивашук, А. В. Архипов, А. С. Яновский, and А. Д. Воропаева. "PROSPECTS FOR THE USE OF MOLECULAR MARKERS TO DETECT 1BL/1RS TRANSLOCATION IN WHEAT." In Биотехнология в растениеводстве, животноводстве и сельскохозяйственной микробиологии. Crossref, 2021. http://dx.doi.org/10.48397/arriab.2021.21.xxi.031.

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Один из подходов к увеличению генетического разнообразия пшеницы основан на интрогрессивной гибридизации, обеспечивающей перенос новых генов в геном пшеницы. Этот способ использовался для получения высоко адаптивных линий пшеницы с 1BL/1RS замещением от ржи. 1RS фрагмент хромосомы ржи несет гены устойчивости к бурой ржавчине (Lr26), стеблевой ржавчине (Sr31), мучнистой росе (Рm8), а также жёлтой ржавчине (Yr9), вирусу полосатой мозаики (Wsm) и тле (Gbr) [1, 2]. Данный тип транслокации может не только способствовать устойчивости сортов пшеницы к комплексу болезней, но и увеличению массы зёрен,

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Kemp, Regina, Kevin Fraser, Kyoko Fujita, Douglas MacFarlane, and Gloria Elliott. "Biocompatible Ionic Liquids: A New Approach for Stabilizing Proteins in Liquid Formulation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192986.

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The stabilization of proteins is a priority for several important fields, most notably the pharmaceutical industry. Protein-based therapeutic drugs have demonstrated significant efficacy in controlling and curing disease. Unlike traditional small molecule-based drug therapies, a major hurdle in the development of protein drugs is the challenge of maintaining the protein in the folded state throughout processing and also during storage at the end point-of-use. When a protein is taken from its native environment, it is often unstable and unfolds. Because the protein’s 3-dimensional structure is

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Raporty organizacyjne na temat "Protein Based Molecular Diseases"

Matthews, Lisa, Guanming Wu, Robin Haw, et al. Illuminating Dark Proteins using Reactome Pathways. Reactome, 2022. http://dx.doi.org/10.3180/poster/20221027matthews.

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Diseases are often the consequence of proteins or protein complexes that are non-functional or that function improperly. An active area of research has focused on the identification of molecules that can interact with defective proteins and restore their function. While 22% percent of human proteins are estimated to be druggable, less than fifteen percent are targeted by FDA-approved drugs, and the vast majority of untargeted proteins are understudied or so-called "dark" proteins. Elucidation of the function of these dark proteins, particularly those in commonly drug-targeted protein families,

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Gafny, Ron, A. L. N. Rao, and Edna Tanne. Etiology of the Rugose Wood Disease of Grapevine and Molecular Study of the Associated Trichoviruses. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575269.bard.

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Rugose wood is a complex disease of grapevines, characterized by modification of the woody cylinder of affected vines. The control of rugose wood is based on the production of healthy propagation material. Detection of rugose wood in grapevines is difficult and expensive: budwood from tested plants is grafted onto sensitive Vitis indicators and the appearance of symptoms is monitored for 3 years. The etiology of rugose wood is complex and has not yet been elucidated. Several elongated clostero-like viruses are consistently found in affected vines; one of them, grapevine virus A (GVA), is close

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Ohad, Nir, and Robert Fischer. Regulation of plant development by polycomb group proteins. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695858.bard.

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Our genetic and molecular studies have indicated that FIE a WD-repeat Polycomb group (PcG) protein takes part in multi-component protein complexes. We have shown that FIE PcG protein represses inappropriate programs of development during the reproductive and vegetative phases of the Arabidopsis life cycle. Moreover, we have shown that FIE represses the expression of key regulatory genes that promote flowering (AG and LFY), embryogenesis (LEC1), and shoot formation (KNAT1). These results suggest that the FIE PcG protein participates in the formation of distinct PcG complexes that repress inappr

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Bar-Joseph, Moshe, William O. Dawson, and Munir Mawassi. Role of Defective RNAs in Citrus Tristeza Virus Diseases. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575279.bard.

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This program focused on citrus tristeza virus (CTV), the largest and one of the most complex RNA-plant-viruses. The economic importance of this virus to the US and Israeli citrus industries, its uniqueness among RNA viruses and the possibility to tame the virus and eventually turn it into a useful tool for the protection and genetic improvement of citrus trees justify these continued efforts. Although the overall goal of this project was to study the role(s) of CTV associated defective (d)-RNAs in CTV-induced diseases, considerable research efforts had to be devoted to the engineering of the h

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Sessa, Guido, та Gregory Martin. MAP kinase cascades activated by SlMAPKKKε and their involvement in tomato resistance to bacterial pathogens. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7699834.bard.

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The research problem: Pseudomonas syringae pv. tomato (Pst) and Xanthomonas campestrispv. vesicatoria (Xcv) are the causal agents of tomato bacterial speck and spot diseases, respectively. These pathogens colonize the aerial parts of the plant and cause economically important losses to tomato yield worldwide. Control of speck and spot diseases by cultural practices or chemicals is not effective and genetic sources of resistance are very limited. In previous research supported by BARD, by gene expression profiling we identified signaling components involved in resistance to Xcvstrains. Follow u

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Vakharia, Vikram, Shoshana Arad, Yonathan Zohar, Yacob Weinstein, Shamila Yusuff, and Arun Ammayappan. Development of Fish Edible Vaccines on the Yeast and Redmicroalgae Platforms. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699839.bard.

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Betanodaviruses are causative agents of viral nervous necrosis (VNN), a devastating disease of cultured marine fish worldwide. Betanodavirus (BTN) genome is composed of two single-stranded, positive-sense RNA molecules. The larger genomic segment, RNA1 (3.1 kb), encodes the RNA-dependent RNA polymerase, while the smaller genomic segment, RNA 2 (1.4kb), encodes the coat protein. This structural protein is the host-protective antigen of VNN which assembles to form virus-like particles (VLPs). BTNs are classified into four genotypes, designated red-spotted grouper nervous necrosis virus (RGNNV),

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Citovsky, Vitaly, and Yedidya Gafni. Viral and Host Cell Determinants of Nuclear Import and Export of the Tomato Yellow Leaf Curl Virus in Tomato Plants. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7585200.bard.

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Tomato yellow leaf curl geminivirus (TYLCV) is a major pathogen of cultivated tomato, causing up to 100% crop loss in many parts of the world. In Israel, where TYLCV epidemics have been recorded since the 1960' s, this viral disease is well known and has been of economic significance ever since. In recent years, TYLCV outbreaks also occurred in the "New World" - Cuba, The Dominican Republic, and in the USA, in Florida, Georgia and Louisiana. Thus, TYLCV substantially hinders tomato growth throughout the world. Surprisingly, however, little is known about the molecular mechanisms of TYLCV inter

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Ehrlich, Marcelo, John S. Parker, and Terence S. Dermody. Development of a Plasmid-Based Reverse Genetics System for the Bluetongue and Epizootic Hemorrhagic Disease Viruses to Allow a Comparative Characterization of the Function of the NS3 Viroporin in Viral Egress. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699840.bard.

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Project Title: "Development of a plasmid-based reverse genetics system for the Bluetongue and Epizootic Hemorrhagic Disease viruses to allow comparative characterization of the function of the NS3 viroporin in viral egress". Project details: No - IS-4192-09; Participants – Ehrlich M. (Tel Aviv University), Parker J.S. (Cornell University), DermodyT.S. (Vanderbilt University); Period - 2009-2013. Orbiviruses are insect-borne infectious agents of ruminants that cause diseases with considerable economical impact in Israel and the United States. The recent outbreaks of BTV in Europe and of Epizoot

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Young, Erin, Cem Kuscu, Christine Watkins, and Murat Dogan. Using CRISPR Gene Editing to Prevent Accumulation of Lipids in Hepatocytes. University of Tennessee Health Science Center, 2022. http://dx.doi.org/10.21007/com.lsp.2022.0007.

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CRISPR gene editing is a molecular technology that can be used to silence gene expression. In this experiment, genes that are known to play a role in lipid accumulation in hepatocytes were targeted. Specifically, levels of fatty acid transport proteins 2 and 5 (FATP2 & 5) have been shown to be elevated in cases of non-alcoholic fatty liver disease. The goal of this experiment was to reduce expression of these genes by using a dead Cas9 (dCas9) protein with an attached inhibitory domain (KRAB) that acts on the promotor region. When measuring the mRNA expression, it was determined that the l

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Manulis, Shulamit, Christine D. Smart, Isaac Barash, Guido Sessa, and Harvey C. Hoch. Molecular Interactions of Clavibacter michiganensis subsp. michiganensis with Tomato. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7697113.bard.

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Clavibacter michiganensis subsp. michiganensis (Cmm), the causal agent of bacterial wilt and canker of tomato, is the most destructive bacterial disease of tomato causing substantial economic losses in Israel, the U.S.A. and worldwide. The molecular strategies that allow Cmm, a Gram-positive bacterium, to develop a successful infection in tomato plants are largely unknown. The goal of the project was to elucidate the molecular interactions between Cmmand tomato. The first objective was to analyze gene expression profiles of susceptible tomato plants infected with pathogenic and endophytic Cmms

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