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Rozprawy doktorskie na temat „Proteins Synthesis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 30 lipca 2024

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1

Baas, Tracey Lynn. "The design, synthesis, and characterization of template assembled synthetic proteins /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11561.

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2

Draffan, Lynda Catherine. "Chemical synthesis of proteins." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/13715.

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3

Morton, Gail Helen. "The chemical synthesis of proteins." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/15437.

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The viability of extending the present methodology designed for the solid phase synthesis of peptides has been investigated. Using the catalytic domain of stromelysin (SCD. 173 residues) as the model system, a number of different factors affecting the preparation and purification of chemically synthesised proteins are examined. The purification SCD, prepared using stepwise solid phase synthesis is described. Following characterisation, it is evident that protein of the correct primary sequence has been prepared, furthermore, preliminary studies centred on the enzymatic activity of SCD indicate

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4

Walker, Douglas Gordon. "Characterization of immediate-early and early proteins of murine cytomegalovirus synthesized in permissive and nonpermissive cells." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25985.

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The gene products produced by murine cytomegalovirus (MCMV) in infected cells prior to viral DNA synthesis are believed to control the interaction of the virus with the cells, determining whether a permissive infection results, with virus replication, or whether further virus gene expression is inhibited, resulting in a latent or abortive infection. The aim of this study was to characterize the early viral gene products that are produced in permissive and nonpermissive cells. The proteins produced in 3T3-L1 cells, permissively infected with MCMV, during the first six hours of infection (the p

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5

Scott, Felicia Yi Xia. "Controlled Hybrid Material Synthesis using Synthetic Biology." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/86147.

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The concept of creating a hybrid material is motivated by the development of an improved product with acquired properties by amalgamation of components with specific desirable traits. These new attributes can range from improvements upon existing properties, such as strength and durability, to the acquisition of new abilities, such as magnetism and conductivity. Currently, the concept of an organic-inorganic hybrid material typically describes the integration of an inorganic polymer with organically derived proteins. By building on this idea and applying the advanced technologies available tod

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6

Schwartz, Anne. "Characterization of normal and androgen resistant-genital skin fibroblasts using high-resolution two-dimensional gel electrophoresis." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63378.

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7

Zhang, Yinfeng, and 张银凤. "Protein chemical synthesis by serine and threonine ligation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/202359.

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Landmark advances in the field of synthetic protein chemistry have enabled the preparation of complex, homogeneous proteins, including those that carry specific posttranslational modifications (PTMs). In addition, chemical synthesis will allow one to incorporate unnatural elements to generate new biologics with altered properties and functions. Native chemical ligation (NCL) is a milestone in the chemical synthesis of proteins (Kent et al., Science, 1994, 266, 776-779), in which a C-terminal peptide thioester and an N-terminal cysteine (Cys)-containing peptide-both in side-chain unprotected fo

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8

Johnston, Julie Catherine. "In vitro translation of cucumber necrosis virus RNA." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28969.

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The in vitro translation products directed by cucumber necrosis virus (CNV) RNA were analyzed in both rabbit reticulocyte lysate and wheat germ extract cell-free translation systems. In rabbit reticulocyte lysates, one major protein of ca. 33 Mr was produced. In wheat germ extracts, four proteins of ca. 41, 33, 21 and 20 Mr were produced. Hybrid-arrested translation (HART) studies using synthetic CNV antisense RNA corresponding to the entire CNV genome demonstrated that the four major proteins synthesized from CNV virion RNA in wheat germ extracts are virus-specific translation products. The g

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9

Sun, Xiaojiao. "High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation." Doctoral thesis, Uppsala universitet, Fysikalisk-organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183203.

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This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. Competition SPR experiments or other methods proved that the small

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10

Kim, Daniel. "Characterization of the Mata pre-." Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/738.

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11

Lindgren, Joel. "Chemical Engineering of Small Affinity Proteins." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-141014.

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Small robust affinity proteins have shown great potential for use in therapy, in vivo diagnostics, and various biotechnological applications. However, the affinity proteins often need to be modified or functionalized to be successful in many of these applications. The use of chemical synthesis for the production of the proteins can allow for site-directed functionalization not achievable by recombinant routes, including incorporation of unnatural building blocks. This thesis focuses on chemical engineering of Affibody molecules and an albumin binding domain (ABD), which both are three-helix bu

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12

Brown, Angus R. "Solid phase synthesis of peptides and proteins." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/27313.

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A strategy for the total chemical synthesis and purification of proteins has been investigated and applied to the 85 residue methylated DNA binding domain (MBD) from the chromosomal protein MeCP2, the 66 residue Restriction Alleviation (Ral) protein from bacteriophage λ and the 76 residue β-chemokine Monocyte Chemotactic protein (MCP-1). The hydrophobicity of the N<SUP>α</SUP> protecting group tetrabenzo[a,c,g,i]fluorenyl-17-methoxycabonyl (Tbfmoc) has been exploited to simplify the rapid purification of the 85 amino acid MBD protein by Hplc. Initial structural studies on the synthetic protein

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13

Wuu, Jessica Ja-li. "Cell-free synthesis of integral membrane proteins /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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14

Yoo, Tae Hyeon Tirrell David A. Tirrell David A. "Proteins of novel composition : synthesis, evolution, dynamics /." Diss., Pasadena, Calif. : California Institute of Technology, 2008. http://resolver.caltech.edu/CaltechETD:etd-03202008-163647.

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15

Neubauer, Cajetan Simon Johannes. "Structural aspects of quality control in protein synthesis." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609457.

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16

Misra, Rajeev. "Studies on the TolC protein of Escherichia coli K-12 and its effect on OmpF expression." Title page, table of contents and abstract only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phm678.pdf.

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17

Sadow, Jennifer Beth Hurley. "The X-ray crystal structure of wheat translation initiation factor eIF4E /." Thesis, Full text (PDF) from UMI/Dissertation Abstracts International, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3085056.

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18

Renberg, Björn. "Fluorescence-based ligand assays for protein detection using affibody affinity proteins." Doctoral thesis, KTH, Skolan för bioteknologi (BIO), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3936.

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The detection and quantification of biomolecules, and proteins in particular, are of great interest since these molecules are of fundamental importance to our well-being. Body fluids, as for instance human blood, are well suited for sampling of protein levels. However, the complexity of the fluids and the low abundance of many of the interesting biomolecules makes detection and quantification difficult. This has spurred an interest into the development of many protein detection methods, and of these, ligand assays have proven particularly suitable. In this thesis, different types of ligand ass

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19

Haas, R. Matthew. "Synthesis and characterization of phosphono-CheY from Thermotoga maritima /." Electronic version (PDF), 2007. http://dl.uncw.edu/etd/2007-1/haasr/rmatthewhaas.html.

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20

Cassidy, Peter Joseph. "The design and synthesis of peptide turn mimetics /." St. Lucia, Qld, 1998. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16396.pdf.

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21

Tang, Chi-wai Sydney, and 鄧智偉. "Human kidney as an organ of complement synthesis: its regulation by tubular protein." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31981768.

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22

Wei, Hen-Wei. "Effect of long-term amino-acid deficiency on the amino-acid composition of the body." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302436.

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The aim of this study was to assess changes in the amino-acid composition of the body and in the fractional protein synthesis rates of individual organs or of haemoglobin as a result of long-term amino-acid deficiency in both growing and adult animals. The body weight loss of adults and the growth rates of growing animals were controlled by adjusting the degree of amino-acid deficiency according to individual body weight changes. Adult rats given amino acid-deficient diets had lower absolute weights of muscle (p = 0.052), liver (p = 0.002) and gastrointestinal tract (p < 0.001) than adequately

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23

Narayanan, Pushpa. "Isolation and characterisation of novel ribosome-inactivating proteins from the root tubers of Trichosanthes kirilowii / Pushpa Narayanan." HKBU Institutional Repository, 1996. http://repository.hkbu.edu.hk/etd_ra/67.

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24

Baldridge, Anthony Owen. "Synthesis, photophysics, and application of fluorescent protein chromophore analogs." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44744.

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The green fluorescent protein chromophore exhibits remarkably different properties upon removal from the protective beta-barrel. This work focuses on the synthesis of these chromophores as wells studying the photophysics as to why they readily deactivate. Following these initial discoveries, these chromophores can be applied to many different environments providing a fluorescence "turn-on" and thus proving to be applicable in a number of different environments and fields.

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25

Connors, Mark Terence. "The investigation of the parameters of protein synthesis and translational efficiency in the ovine /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16926.pdf.

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26

Perera, Aruna B. Kane Robert R. "Modification of fresh tissue surfaces ; synthesis of labeled L-dopa analogs; and synthesis of metoclopramide analogs /." Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/2998.

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27

Nagalingam, Anil. "Towards the total synthesis of bacterial immunity proteins." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427784.

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28

Lear, Sam. "Total synthesis of bioactive peptides and whole proteins." Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11946/.

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Total chemical synthesis is an essential tool for the validation of natural product structures and the discovery and elaboration of novel therapeutic scaffolds. Chapter 1 (Part I) surveys existing treatments for trypanosomatid neglected tropical diseases, and the synthesis of a novel class of antiparasitic cyclic depsipeptides is reported (Chapter 2) alongside a full NMR assignment and structure calculation using NMR-derived distance restraints. The synthetic peptides exhibit activity profiles in agreement with published results, and a series of ester-to-amide substitution analogues also synth

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29

Mitchell, Christopher J. "The regulation of polyphosphoinositide synthesis in rat liver." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389879.

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30

Zhang, Guangtao. "Design, synthesis, and evaluation of cholera toxin inhibitors and [alpha]-helix mimetics of dormancy survival regulator /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8485.

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31

Thompson, Robert E. A. "Strategies for the synthesis of posttranslationally modified peptides and proteins." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11435.

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Posttranslational modifications (PTMs) are ubiquitous chemical alterations that are made to peptides and proteins after ribosomal synthesis. The non-templated nature of PTMs hinders the ability to study an individual isoform of a given protein, which may be expressed as complex mixtures in vivo. This thesis describes ligation-based strategies for use in the chemical synthesis of PTM peptides and proteins. Chapter one describes the development of a synthesis of the antibacterial PTM peptide microcin B17 (MccB17). Using Ag(I)-ligation chemistryMccB17 was synthesised efficiently from three precur

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32

Ghannad, Mona. "Design and Synthesis of Collagen-binding Anti-microbial Proteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19981.

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The Herpes simplex virus (HSV) is a virus that commonly infects the skin, and mucous membrane of the mouth, genitalia, and the eye. HSV-1 is the strain that is most commonly associated with corneal infections, and it is the most frequent cause of corneal blindness in North America [1]. Currently no cure is available, and many limitations are characterized by the currently available synthetic antiviral drugs, which suggest the need for other potential drug alternatives and delivery strategies. Anti-microbial peptides are naturally occurring peptides that are potent killers of a broad range of m

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33

Kotaras, Peter J. "Synthesis and secretion of rat pineal proteins in-vitro /." Title page, contents and abstract only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phk871.pdf.

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34

Hui, Daniel Jason. "The Mechanism of Protein Synthesis Inhibition by the P56 Family of Viral Stress Inducible Proteins." Connect to text online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1104848977.

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35

Dingwall, C. "The accumulation of proteins in the Xenopus oocyte nucleus." Thesis, Open University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354967.

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The ability of proteins to accumulate in the nucleus has been studied by injecting nucleoplasmin and calf thymus histone H1 into the cytoplasm of Xenopus oocytes. Nucleoplasmin, the most abundant protein in the Xenopus oocyte nucleus is pentameric and proteolysis of the nuceloplasmin pentamer produces a relatively protease resistant 'core' molecule that cannot enter the nucleus after microinjection into the cytoplasm. The polypeptide domain ('lq tail') of each subunit removed by proteolysis was obtained as a discrete fragment and has the ability to accumulate in the nucleus. Partially cleaved

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36

Huang, Edwin P. C. Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Recombinant protein production utilising a metallothionein expression system and a Super-CHO cell line." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2006. http://handle.unsw.edu.au/1959.4/24940.

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A novel metal-inducible and amplifiable metallothionein (MT) expression system, pNK, was firstly optimised and characterised for the production of a reporter protein, human growth hormone (hGH) in a suspension CHO cell line grown in a serum-free media. The pNK-based hGH production was demonstrated in cadmium-free condition under various fermentation modes (batch, fed-batch and perfusion) and scales (flask to bench-top bioreactor). Improvement of specific productivity of recombinant protein from pNK was shown to be possible by addition of butyrate or substrate substitution of glutamine by gluta

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37

Adedeji, Dolapo A. Duin Evert C. "Isoprenoid synthesis new roles for iron sulfur clusters /." Auburn, Ala., 2007. http://repo.lib.auburn.edu/Send%2002-04-08/ADEDEJI_DOLAPO_4.pdf.

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38

Tang, Norina Mei Ngon. "Regulation of protein synthesis and induction of oncogenesis by a cellular protein kinase inhibitor /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/11501.

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39

Tang, Chi-wai Sydney. "Human kidney as an organ of complement synthesis : its regulation by tubular protein /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23295181.

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40

Suleman, Essa. "Mutational analysis of the PacC binding sites within the aflR promoter in Aspergillus flavus." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/d1012683.

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It is generally known that media containing simple sugars (sucrose, glucose) and organic nitrogen sources (ammonium) when buffered to acidic pH stimulates aflatoxin production in Aspergillus flavus & A. parasiticus while lactose, nitrate and an alkaline pH inhibit aflatoxin biosynthesis. It has been shown that pH of the growth medium is the most important regulatory factor for aflatoxin biosynthesis since media containing stimulatory carbon and/or nitrogen sources (sucrose and ammonia) do not enhance aflatoxin (or sterigmatocystin) production at alkaline pH. RNA interference (in A. flavus) of

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41

Schinn, Song Min. "Cell-Free Synthesis of Proteins with Unnatural Amino Acids: Exploring Fitness Landscapes, Engineering Membrane Proteins and Expanding the Genetic Code." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6496.

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Unnatural amino acids (uAA) expand the structural and functional possibilities of proteins. Numerous previous studies have demonstrated uAA as a powerful tool for protein engineering, but challenges also remain. Three notable such challenges include: (1) the fitness of uAA-incorporated proteins are difficult to predict and time-consuming to screen with conventional methods, (2) uAA incorporation in difficult-to-express proteins (e.g. membrane proteins such as G-protein coupled receptors) remain challenging, and (3) the incorporation of multiple types of uAA are still limited. In response, we p

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42

Vinogradov, Alexander Alexandrovich. "New methods for synthesis and modification of peptides and proteins." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/109680.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Chemical modification of peptides and proteins is an enabling suite of tools for tailoring the properties of these biomolecules to specific applications. A number of bio-conjugation reactions allows fine-tuning of the biological activity, proteolytic stability, and immunogenicity of peptides and proteins, as well as equipping them with completely novel functions such as cell penetration, fluorescence, unique chemical reactivit

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43

Patterson, Jennifer Ann. "The chemical synthesis of proteins and peptide C-terminal derivatives." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/12777.

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Methodology for the synthesis of peptide <i>C</i>-terminal aldehydes has been investigated. Modification of a linker system, based on a terabenzosuberyl construct, has been demonstrated to be suitable for the synthesis of peptide <i>C</i>-terminal semicarbazones. The route has been fully optimised to yield a series of peptide <i>C</i>-terminal semicarbazones and the corresponding peptide aldehydes. The chemical synthesis of deglycosylated human interferon-gamma (143 residues) has been carried out. The purification of this protein has been investigated and a short purification protocol develope

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44

Hsieh, Yves Shang-Yi. "Chemical Synthesis of Peptides & Proteins with Post-Translational Modifications." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9422.

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This thesis describes efforts aimed at the synthesis of peptides and proteins bearing homogeneous carbohydrate and sulfate modifications for interrogation of the structural and functional roles of these post-translational modifications. This thesis is divided into two parts. The first section (Chapter Two and Chapter Three) describes efforts toward the synthesis of glycopeptides. Chapter Two describes the synthesis of rare S-linked glycopeptide sublancin-168 and its glycosylated variants, along with structural studies to understand the effect of S-glycosylation. Chapter Three outlines the isol

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45

Blanshard, Maximilian Edward Alfred. "Synthesis of recombinant antibacterial proteins in the Chlamydomonas reinhardtii chloroplast." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045326/.

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The rise of antibiotic resistance and the decline in antibiotic discovery have been well publicised. These issues, in combination with a growing global reliance upon antibiotics for everyday modern life, urgently require the discovery of novel antibacterial drugs. Endolysins are one potential candidate to support, or replace, conventional antibiotics. Endolysins are lytic enzymes produced by bacteriophage in natura to enable the release of viral progeny from inside the host bacterium. When applied exogenously, endolysins can lyse Gram-positive bacteria, and thus could be used as a novel antiba

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46

Patel, Amar S. "Synthesis of Aromatic Monothiols and Aromatic Dithiols to Increase the Folding Rate and Yield of Disulfide Containing Proteins." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/313.

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Most pharmaceutically relevant proteins and many extracellular proteins contain disulfide bonds. Formation of the correct disulfide bonds is essential for stability in almost all cases. Disulfide containing proteins can be rapidly and inexpensively overexpressed in bacteria. However, the overexpressed proteins usually form aggregates inside the bacteria, called inclusion bodies, which contains inactive and non-native protein. To obtain native protein, inclusion bodies need to be isolated and resolubilized, and then the resulting protein refolded in vitro. In vitro protein folding is aided by t

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47

Ellsmore, Victoria. "Human cytomegalovirus origin-dependent DNA synthesis." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340332.

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48

Dodd, Sara. "Hydrodynamic and hydrogel properties of mucins from cultured guinea-pig tracheal epithelial cells." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287166.

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49

Gillespie, Charles Stewart. "Myelin membrane protein biosynthesis : an in vitro study." Thesis, University of Stirling, 1988. http://hdl.handle.net/1893/22868.

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The sites of biosynthesis and incorporation of the abundant CNS myelin proteins 2' , 3' -cyclic nucleotide-3'-phosphodiesterase (CNPase) and P2 protein into the growing myelin membrane were investigated. Cell-free translation systems programmed with mRNA from rat brain, rabbit spinal cord, free and bound polysomes and purified myelin demonstrated conclusively that both CNPase and P2 are synthesized on free polysomes like the myelin basic proteins (MBPs) but unlike the proteolipid protein (PLP), the major intrinsic membrane protein of CNS myelin, which is known to be synthesized at the oligoden

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50

Pfeffer, Frederick Matthew, and mikewood@deakin edu au. "Approaches to the synthesis of peptide substituted frameworks." Deakin University. School of Biological and Chemical Sciences, 2000. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20060713.125622.

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The 1,3 dipolar cycloaddition between carbonyl ylids (generated from cyclobutene epoxides flanked by esters) and norbornyl alkenes the ACE reaction offers a facile method for the construction of polynorbornyl molecular frameworks. This reaction has, as described in this dissertation, underpinned the construction of molecular frameworks that have peptides and amino acids attached. Such highly rigid peptide-frameworks are of use in the field of peptidomimetics; the template molecule governs the final positioning of any attached groups such that a precise arrangement of amino acids can be a

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