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Rozprawy doktorskie na temat „Proteolysis”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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1

El-Daher, Marie-Thérèse. "Huntingtin proteolysis and toxicity." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T029/document.

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La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire autosomique dominante. Elle est due à l’expansion anormale de polyglutamine dans la partie N-terminal de la protéine huntingtine (HTT). Une des étapes clés de la pathologie est le clivage de la HTT pleine longueur en fragments N-terminaux plus petits, contenant l’expansion de polyglutamine, et qui sont toxiques pour les neurones. En effet, les clivages de la HTT mutée génère des fragments N-terminaux (N-ter) de tailles comprises entre les acides aminés 1-105 et 1-586 observés dans des extraits de cerveaux de patients M
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2

Clay, L. "CDC20 function, regulation and proteolysis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597750.

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The destruction of mitotic cyclins and other key regulators uses ubiquitin mediated proteolysis controlled via the activation of the ubiquitin ligase the Anaphase Promoting Complex/Cyclosome (APC/C), and its adaptor proteins Cdc20 and Cdh1. The spindle assembly checkpoint coordinates the APC/C with microtubule attachment and sets the timing from NEBD to anaphase. Cdc20 is inactivated by the spindle assembly checkpoint to prevent premature anaphase onset. Once the spindle assembly checkpoint is satisfied, Cdc20 can be released and activate the APC/C. However, cyclin A is degraded independently
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3

Slee, Adrian. "Regulation of skeletal muscle proteolysis." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/13105/.

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Proteolysis is a component of protein turnover, controlled by multiple proteolytic systems. Alterations in system components within skeletal muscle has been associated with hypertrophy, remodelling, atrophy, apoptosis and metabolic dysregulation. Key components may have novel regulatory roles, e. g. calpain-3 and cathepsin-L. Experiments described within this thesis investigated the hypothesis that the gene expression of specific proteolytic system components within skeletal muscle may be co-ordinately regulated and altered during nutritional and pharmacological states known to modify protein
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4

Andréasson, Claes. "Ligand-activated proteolysis in nutrient signaling /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-075-3/.

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5

Hutton, David Alan. "Studies on mucin isolation and proteolysis." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287272.

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6

Canning, Mary. "Ubiquitin-mediated proteolysis and Drosophila embryogenesis." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/13305.

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Ubiquitination provides a means of rapidly and irreversibly eliminating an unwanted protein from the cell, and is therefore a potentially effective tool for regulating cellular behaviour. Ubiquitin-mediated proteolysis is involved in such diverse physiological functions as growth control, cell signalling, differentiation and the immune response. The aim of this research has been to investigate its role in <i>Drosophila </i>embryogenesis. Protein ubiquitination is a stepwise process carried out by three classes of enzyme known as E1s, E2s and E3s. The E1 (ubiquitin-activating enzyme), generates
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7

Smith, Kate L. "Tumour associated proteolysis and protein metabolism." Thesis, Aston University, 1992. http://publications.aston.ac.uk/12604/.

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The effect of cancer cachexia on protein metabolism has been studied in mice transplanted with the MAC16 adenocarcinoma. The progressive cachexia induced by the MAC16 tumour was characterised by a reduction in carcass nitrogen between 16-30% weight loss and a reciprocal increase in tumour nitrogen content. Carcass nitrogen loss was accompanied by a concomitant decrease in gastrocnemius muscle weight and nitrogen content and also by a decrease in liver nitrogen content. The loss of gastrocnemius muscle throughout the progression of cachexia was attributable to a 60% decrease in the rate of prot
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8

Lemberg, Marius Kaspar. "Intramembrane proteolysis by the aspartic protease SPP /." Zürich, 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15327.

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9

Potocka, Isabel. "Cell-cycle regulated proteolysis in Caulobacter crescentus." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252229.

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10

Campbell, William. "Characterisation of the proteolysis of chromogranin A." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301777.

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11

Brose, Michael C. "Fujinami sarcoma virus P140 proteolysis and peptide purification." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24487.

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Fujinami sarcoma virus encodes a 140/000 m.w. polypeptide (P140) which has been correlated as the agent of transformation in host chicken fibroblasts and mammalian fibroblasts. To conclusively identify the role of P140 in the transformation process it will be necessary to obtain intact/ purified P140. The availability of an antibody monoclonally specific to the N-terminal gag encoded portion of P140 suggested a one-step immunoaffinity purification of P140. After purification of the antibody out of mouse ascites fluid, by 50% ammonium sulfate fractionation and ion exchange chromatography, antib
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12

Zhang, Ying. "Function of SPX and its control by proteolysis /." Full text open access at:, 2007. http://content.ohsu.edu/u?/etd,264.

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13

Fairbairn, Robert L. "Proteolysis associated with the fermentation of ensiled forage." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75861.

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Chopped alfalfa and chopped whole-plant corn were ensiled and the proteolytic changes which occurred during ensiling were investigated. Proteolysis was measured in terms of end-products of protein degradation and by protein isolation followed by electrophoresis. The effects of formic acid and ammonia, applied at the time of ensiling, on proteolytic changes were investigated.<br>Alfalfa treated with formic acid contained significantly reduced levels of NH$ sb3$-N and NPN compared to control silage; ammonia (NH$ sb3$)-treated alfalfa silage had significantly less NPN (P $<$ 0.05). After 90d of s
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14

Stanton, Catherine. "Proteolysis-induced changes in meat collagen during conditioning." Thesis, Bournemouth University, 1988. http://eprints.bournemouth.ac.uk/298/.

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Changes in intramuscular connective tissue brought about by conditioning were investigated in bovine muscles of different quality. Perimysial and endomysial collagens were solubilized to a small extent during conditioning and residual insoluble collagens in both connective tissue domains were damaged by proteolytic processing. Yields of soluble perimysial material from unconditioned muscles were significantly lower (p = 0.096) than from conditioned muscles. Solubilized perimysial collagen from unconditioned muscles was significantly lower (p = 0.015) than from conditioned muscles with 1±0.8 %
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15

Rusbridge, Nicholas Mercer. "Tryptic proteolysis of glycogen phosphorylase b in vitro." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317367.

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16

Newman, Andrew. "The regulation of L-selectin activity by proteolysis." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/103855/.

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L-selectin (CD62L) is a type I transmembrane protein expressed by lymphocytes which directs their migration from the bloodstream into lymph nodes and infected tissues. Stimulation of the T cell receptor (TCR) activates the enzyme A Disintegrin and Metalloproteinase 17 (ADAM 17), which cleaves L-selectin at the ectodomain generating a metalloproteinase product (MP product) comprising of a transmembrane region and a 17-amino acid intracellular domain (ICD). ϒ-secretase is a multi-subunit protease that cleaves up to 90 identified type I transmembrane proteins in the intramembrane region following
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17

Fraser-Smith, Emma Louise. "Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure". The University of Waikato, 2006. http://hdl.handle.net/10289/2253.

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Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that we understand the mechanism of meat tenderisation of which, the calpain protease system is believed to play a central role. This thesis focuses on three aspects; characterisation of calpain activity, the effect of porcine μ-calpain on myofibril degradation and the effect of μ-calpain on specific proteins desmin and troponin-T. To study the eff
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18

Alban, Andrew. "The interactions of ubiquiton-containing proteins with S5a and the 26S proteasome." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323187.

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19

Sivertsson, Elin Maria. "Enzymatic degradation of topologically simple and complex proteins." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708862.

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20

Hsu, Melissa Karen. "Effect of Post Manufacture Thermal Dip Treatment on Proteolysis of Commercial String Cheese During Storage." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/924.

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String cheese, a Mozzarella cheese, has the unique ability to string in fibrous strands when pulled apart. Graders judge string cheese by its stringy texture; samples with copious amounts of string are awarded high ratings. But just as the texture of natural cheeses softens with time, the stringy texture of string cheese can diminish with age too. Age related softening in cheese is due primarily to an important biochemical event known as proteolysis, which is attributed to inherent milk proteinases, residual coagulant activity, and enzymes from the lysis of starter culture microorganisms. It i
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21

Rozkov, Aleksei. "Control of Proteolysis of Recombinant Proteins in Escherichia coli." Doctoral thesis, KTH, Biotechnology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3227.

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22

Solomonson, Matthew Morris. "Structure, proteolysis, and evolution of secreted tuberculosis virulence factors." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54572.

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Mycobacterium tuberculosis uses the ESX-1 type VII secretion system to export proteins to its cell surface, which permeabilize the host macrophage phagosomal membrane, allowing the bacterium to escape and spread to new cells. The structure of the type VII membrane complex and how it mediates this function is unknown, but it is hypothesized that some of the secreted proteins form an extracellular appendage that facilitates membrane lysis or direct secretion of virulence factors into the host cytoplasm. This thesis investigates the structural relationship between one of these secreted proteins,
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23

Chove, Lucy Mlipano. "Detection of proteolysis in milk by four selected methods." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515687.

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24

Cooke, F. M. "The role of localisation in regulating proteolysis in mitosis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597941.

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In order to maintain genetic fidelity and to avoid aberrant proliferation, the cell cycle must be carefully regulated. Progression through mitosis is controlled by ubiquitin-mediated proteolysis of cell cycle proteins, allowing each stage in the cell division process to begin only when the previous stage is successfully completed and the various checkpoints are satisfied. As proteolysis contributes to the correct timing of exit from mitosis and cytokinesis, I have investigated the mechanisms responsible for degrading specific proteins at specific times during the cell cycle and how this is reg
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25

Brown, Geraldine Marie. "Extracellular matrix proteolysis by bronchoalveolar leukocytes in experimental pneumoconiosis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19447.

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Neutral proteinases, released by inflammatory leukocytes, have been implicated in the pathogenesis of pneumoconiosis but there has been no systematic study of the proteolytic acitivty of leukocytes from dust-exposed lung. The aim of the present study was, therefore, to assess the bronchoalveolar leukocyte profile and proteolytic activity of the leukocytes in a rat model of pneumoconiosis. An assay, based on the breakdown of [<SUP>125</SUP>I] fibronectin, that would measure the overall proteolytic activity of the bronchoalveolar leukocytes and indicate their potential to damage the connective t
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26

McKinnon, Thomas Antony Jude. "Von Willebrand factor glycans : modifiers of function & proteolysis." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/7380.

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27

Broadfoot, Kerry. "Phosphorylation of Rpn 10 and other proteasome subunits." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251093.

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28

Metodiev, Metodi Dimitrov. "Role of prohibitins for proteolysis in yeast and murine mitochondria /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979125634.

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29

Sherman, Robyn. "Regulation of Histone H3 Proteolysis by Acetylation in Tetrahymena thermophila." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/598.

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Chromatin is the combination of DNA and proteins in the nucleus that is used to aid in the compaction of DNA. Histones are a group of proteins used to condense DNA by forming a complex (nucleosome) around which DNA wraps around; there are two of each type of histone in a nucleosome: H2A, H2B, H3 and H4. Once the DNA is wrapped around the histones, the genome is further compacted. A shortened, "clipped" version of histone H3 has been found in some organisms including yeasts, flies, mammalian stem cells, and the ciliated protozoan, Tetrahymena thermophila. In each organism, clipping occurs at a
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30

Lowrie, A. G. "Neoplastic expression and cellular functions of proteolysis inducing factor/dermcidin." Thesis, University of Edinburgh, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654076.

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Proteolysis inducing factor (PIF) is a pro-cachectic glycopeptide purified from the urines of mice inoculated with the MAC16 tumour and from the urines of weight losing patients with pancreatic carcinoma. It arises from the dermcidin gene which produces 2 other peptides, Y-P30, an unglycosylated neuronal survival factor with homology to the PIF peptide core and DCD-1, an antibiotic peptide secreted by eccrine sweat glands which has no homology with PIF. We sought to investigate PIF / dermcidin expression in cell lines and pancreatic carcinoma tissue, the role of proteolysis inducing factor as
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31

Kemp, Caroline. "The role of caspase-mediated postmortem proteolysis in meat tenderisation." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435987.

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32

Fung, Ella. "Fbxl13 regulates centrosome homeostasis and migration through ubiquitin mediated proteolysis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:5f0198b9-eea7-486f-9860-d006b9ed80e7.

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Fbxl13 (F-box and leucine-rich repeat protein 13) is an orphan F-box protein. Fbox proteins are a family of substrate-targeting specificity factors for the SCF superfamily of E3 ubiquitin ligases. Since their discovery, many F-box proteins have been shown to have oncogenic and tumour suppressive roles. The importance of Fbxl13 itself in tumourigenesis is reflected in several genome-wide shRNA screens. Fbxl13 depletion in human cancer cells correlates with increased ionising radiation sensitivity and increased genomic instability. Furthermore, Fbxl13 depletion reduces proliferation in mouse emb
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33

Ivanushko, Ya G. "Laser radiation effect on the proteolysis state of rat liver." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18209.

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34

Moskaliuk, V. I., and I. I. Moskaliuk. "The role of proteolysis in development of intestinal contractility disorders." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16913.

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35

Mikulets, L. V. "Circadian rhythms of proteolysis indices in patients with rheumatoid arthritis." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18053.

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36

Kirsch, Richard. "Characterisation of fibrinogen and fibrin proteolysis by the neutrophil membrane." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26928.

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Recent studies have identified a novel 600 kDa neutrophil membrane associated protease which degrades fibrinogen, fibrin and C-reactive protein (CRP) during incubation of these ligands with phorbol 12-myristate 13-acetate (PMA, 5-10 ng/ml) stimulated neutrophils. This proteolysis is predominantly an extracellular event which occurs through a ligand dependent release of this protease from the neutrophil. Degradation products arising from this proteolysis not only become neutrophil associated but influence a number of important processes occurring in inflammation and coagulation. The aim of the
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37

Mikita, Natalie. "DEVELOP SPECTROSCOPIC APPROACHES TO STUDY NON-PROTEOSOMAL ATP-DEPENDENT PROTEOLYSIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1401814273.

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38

Mohammad, Kamaruzaman bin. "Proteolysis of zeins in the endosperm of germinating maize seeds." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/53589.

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The pattern and sequence of zein degradation in the endosperm of germinating maize seeds were investigated by sodium dodecyl sulfate polyacrylamide gel electrophoresis and immunoblotting. The proteases involved in the degradation of various zein components (α, ß and γ) were extracted with three buffer systems and partially characterized with respect to their ability to degrade various zein components. They were also investigated in vivo by germinating the seeds in the presence of protease inhibitors used singly and in combination. Of the various zein components, γ-zein (27-kD) was the first
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39

Kim, Ikjin. "Roles of UBL domain containing proteins in proteolysis : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com.libproxy.uthscsa.edu/pqdweb?did=1490071661&sid=4&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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40

Chen, Beibei. "Novel mechanisms for enzymatic regulation of phosphatidylcholine synthesis by proteolysis." Diss., University of Iowa, 2008. https://ir.uiowa.edu/etd/199.

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Pulmonary surfactant is a critical surface-active substance consisting of dipalmitoylphosphatidylcholine (DPPtdCho) and key apoproteins that are produced and secreted into the airspace from alveolar type II epithelial cells. Surfactant deficiency leads to severe lung atelectasis, ventilatory impairment, and gas-exchange abnormalities. These are features of the acute lung injury syndrome, characterized by a strong pro-inflammatory component where cytokines or bacteria infections greatly impair surfactant DPPtdCho biosynthesis. The key enzyme needed to produce surfactant DPPtdCho is a rate-limit
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41

Becerril, Diez Azucena. "Influence of chelating agents on proteolysis of micellar casein slurries." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1635.

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ABSTRACT Influence of chelating agents on proteolysis of micellar casein slurries Azucena Becerril Díez The focus of this research was to analyze the effect of Ca chelators on the proteolytic activity of rennet during ripening of a micellar casein slurry. This research was divided in two phases. During the first phase, preliminary studies were performed to understand the behavior of rennet and the milk system in the presence of chelating agents. A solution of reconstituted skim milk at 10% (w/v) was prepared. Individual samples of this solution were divided in two study groups, samples with ch
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42

Ugolini, Gabriele. "Role of Abnormal Tau Proteolysis in Alzheimer's Disease Neuronal Degeneration." Doctoral thesis, SISSA, 1999. http://hdl.handle.net/20.500.11767/4443.

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Alzheirner' s disease (AD) is characterized by two main histopathological hallmarks: extracellular plaques made of ~-amyloid protein (Selkoe, 1999) and intraneuronal neurofibrillary lesions (Goedert et al., 1996a). Neurofibrillary lesions are accumulations of non-membrane bound bundles of paired helical filaments (PHFs), sometimes interspersed with straight filaments. The sub-unit protein constitutive of PHFs is the microtubule associated protein tau, modified in such way to form insoluble polymers (Delacourte and Buee, 1997). As it is also shown in a preliminary study introducing this work, A
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43

Bottomley, Joanna R. "Enzymological studies of Type II dehydroquinases." Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294656.

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44

Coombs, R. J. "The hormonal control of plasminogen activation in gonadal tissues." Thesis, University of Kent, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235389.

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45

Lu, Lei. "Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-397-3/.

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46

Mareko, Molebeledi Horatius Dambe. "The effects of growth promoters on post- mortem proteolysis in pigs." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602522.

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The inconsistent quality of pork meat is a major worry for the industry, and is mainly blamed on variable tenderness. Meat tenderness depends in part on the degree of alteration of the structural components of muscle and associated proteins post-mortem. Reduced activity of the calpain proteinase system is associated with tough meat. However, it is known that other proteases such caspase and proteasome proteolytic enzyme systems are involved in skeletal muscle development and remodeling, and it is their proteolytic attributes that make them possible contributors to improved meat tenderness. Thi
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47

陈美翩 and Meipian Chen. "Effects of iron overload on apoptosis and titin proteolysis in cardiomyocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193425.

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Iron is one of the essential elements involved in various fundamental biological activities. However, excess iron may bypass the negative feedback regulatory systems, leading to the formation of iron overload. The increase of iron deposition generates cellular toxicity and subsequently damages vital organs. Primary and secondary iron overload are affecting patients worldwide. Iron overload cardiomyopathy is the primary cause of cardiac dysfunction and cardiovascular mortality in β-thalassaemia major patients. Current effective therapy includes chelation treatment with conventional and new iron
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48

Fleck, Daniel. "Regulated intramembrane proteolysis of NRG1 type III dediates postnatal peripheral myelination." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-183725.

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Neuregulin-1 (NRG1) type III is a growth factor on the surface of neurons in the peripheral nervous system (PNS). It is required for initial myelination of nerves by Schwann cells after birth and for remyelination after injury. Neuregulin-1 type III is activated by cleavage (shedding) in its extracellular juxtamembrane region generating a membrane-bound N-terminal fragment (NTF) that contains a bioactive epidermal growth factor (EGF)-like domain. This domain signals to neighboring Schwann cells in a contact-dependent manner prompting the cells to initiate myelination. The β-site APP cleaving e
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49

Roark, Ryan Leigh. "Regulation of ubiquitin-mediated proteolysis in Xenopus laevis and mammalian cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609218.

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50

Fernandez, Marty. "Sequential Proteolysis by γ-Secretase and Its Implications for Alzheimer’s Disease". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467510.

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The production and aggregation of the amyloid β-peptide (Aβ) is thought to play a central role in Alzheimer’s disease (AD) pathogenesis. The presenilin (PS)-containing γ-secretase complex cleaves the amyloid β-protein precursor C-terminal fragment (APP CTFβ) to generate Aβs of 38-49 residues. Evidence suggests that these Aβs are the result of successive γ-secretase cleavages, which are thought to start at the ε sites to generate Aβ48 or Aβ49, followed by C-terminal trimming mostly every three residues to produce secreted Aβs. Specifically, two product lines have been proposed: the Aβ49-46-4
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