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Rozprawy doktorskie na temat „Protozoan diseases”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 sierpnia 2024

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1

Menon, Kathleen I. "Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation." Thesis, Menon, Kathleen I. (2002) Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation. PhD thesis, Murdoch University, 2002. https://researchrepository.murdoch.edu.au/id/eprint/201/.

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The purpose of the present study was to evaluate the potential usefulness of tubulin inhibitors when complexed with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) against a range of protozoan parasites. This approach involved investigations into the complexation of these drugs with HP-beta-CD, and subsequent investigations of these drugs and their complexes in regard to cytotoxicity, pharmacokinetics, in vitro efficacy against Giardia, Cryptosporidium and rodent malaria (Plasmodium chabaudi), and their in vivo efficacy against Giardia and malaria. Albendazole (ABZ) is a benzimidazole carbamat

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Menon, Kathleen I. "Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation." Access via Murdoch University Digital Theses Project, 2002. http://wwwlib.murdoch.edu.au/adt/admin/view/adt-MU20040820.133836.

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3

Martínez, Flórez Alba. "Drug repurposing of bioenergetic modulators: use in treatment and vaccination of protozoan parasitic diseases." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458381.

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Las leishmaniasis, la tripanosomiasis Americana y Africana, y la malaria son enfermedades parasitarias que constituyen un importante problema de salud global que afecta mayoritariamente a países en desarrollo. El aumento del número de resistencias a sus tratamientos actuales, su toxicidad y la necesidad de asistencia sanitaria para la aplicación de los mismos reflejan la urgente necesidad de desarrollar vacunas eficaces y nuevos tratamientos económicos, fáciles de administrar y resistentes a condiciones de almacenamiento adversas. Basándonos en que estas enfermedades parasitarias compart

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4

Saville, William James Allan. "The epidemiology of equine protozoal myeloencephalitis (EPM)." Connect to resource, 1998. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1243352811.

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5

Ulrich, Paul N. "Sensitivity of molluscs to temperature, osmotic shock, and infection by protozoa implications for temperate and polar bivalves /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 267 p, 2007. http://proquest.umi.com/pqdlink?did=1251900721&Fmt=7&clientId=79356&RQT=309&VName=PQD.

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6

Yichoy, Mayte. "Lipid uptake and metabolism in the parasitic protozoan giardia lamblia." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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7

Moyo, Sipho Dugunye. "Comparative study of clan CA cysteine proteases: an insight into the protozoan parasites." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1020309.

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Protozoan infections such as Malaria, Leishmaniasis, Toxoplasmosis, Chaga’s disease and African trypanosomiasis caused by the Plasmodium, Leishmania, Toxoplasma and Trypanosoma genuses respectively; inflict a huge economic, health and social impact in endemic regions particularly tropical and sub-tropical regions. The combined infections are estimated at over a billion annually and approximately 1.1 million deaths annually. The global burden of the protozoan infections is worsened by the increased drug resistance, toxicity and the relatively high cost of treatment and prophylaxis. Therefore th

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8

Al-Dahwi, Zaineb. "Impairment of protective immunity to intestinal helminthiases." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2007. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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9

Arrowood, Michael James. "Cryptosporidium: Oocyst production and hybridoma generation for examining colostrum and monoclonal antibody roles in cryptosporidial infections." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184335.

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Techniques for the large-scale isolation of Cryptosporidium oocysts and sporozoites, obtained from the feces of experimentally infected Holstein calves, were developed employing discontinuous sucrose gradients and isopycnic Percoll gradients. The three step oocyst recovery method utilized two sequential discontinuous sucrose gradients followed by one Percoll gradient. Recovered oocysts were essentially free of debris and bacteria and represented 34% of the original oocyst suspension. Sporozoites were recovered from excystation mixtures on a single Percoll gradient. Sixty-three percent of the o

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10

Heskett, Katherine A. "Investigation of a method to reduce false-positive equine protozoal myeloencephalitis test results title." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0005184.

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Thesis (M.S.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 79 pages. Includes Vita. Includes bibliographical references.

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11

Oliver, Jacques L. "Protease Inhibitors of the Eastern Oyster, Crassostrea virginica, and their Relationship to the Protozoan Pathogen, Perkinsus marinus." W&M ScholarWorks, 1999. https://scholarworks.wm.edu/etd/1539617747.

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12

Chakaingesu, Chikomborero. "Synthesis and structure-activity relationship studies of 1,4-naphthoquinone derivatives as potential anti-trypanosomal agents." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1020959.

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Human African Trypanosomiasis (HAT) is an infectious, vector-borne protozoal disease which is amongst the so-called neglected diseases. In 2000, at a summit of the United Nations, eight Millennium Development Goals (MDGs) were set, to be achieved by 2015. MDG 6 states “to combat HIV/AIDS, malaria & other diseases”. With just under 2 years to go before the end of 2015, HAT is still thriving in developing countries. The drugs currently used for the treatment of HAT are in short supply, have severe side effects and those used to treat late stages of the disease are very difficult to administer. T

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13

Rayo, Camacho Corona Maria del. "Natural products against protozoal diseases." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301221.

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14

Angwin, Catherine-Jane. "ANALYSIS OF HUMORAL IMMUNE RESPONSES IN HORSES WITH EQUINE PROTOZOAL MYELOENCEPHALITIS." UKnowledge, 2017. http://uknowledge.uky.edu/gluck_etds/30.

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Equine protozoal myeloencephalitis (EPM), caused by the protozoan parasite Sarcocystis neurona, is one of the most important neurological diseases of horses in the Americas. While seroprevalence of S. neurona in horses is high, clinical manifestation of EPM occurs in less than 1% of infected horses. Factors governing the occurrence and severity of EPM are largely unknown, although horse immunity might play an important role in clinical outcome. We hypothesize that EPM occurs due to an aberrant immune response, which will be discernable in the equine IgG subisotypes a, b, and (T) that recognize

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15

Townley, David. "Control of brassica clubroot disease using modern anti-protozoal fungicides." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415514.

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16

Davutluoglu, Ayten. "Detection Of Helminth Eggs And Protozoan Cysts In Wastewaters." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605921/index.pdf.

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The withdrawal of water sources concluded the reuse of treated wastewaters, especially for non-potable purposes. Agricultural use of the reclaimed wastewaters is one of the reuse options. However health considerations of the reuse of reclaimed wastewaters for public related purposes are underestimated, since wastewaters contain a variety of microbial pathogens, which may be transmitted to workers and consumers through the crops irrigated. Of these, parasitic eggs have a special place, as they are capable of surviving in the soil for months or even years, depending on environmental conditions.

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17

Cotterell, Sarah Elizabeth Jane. "The production and recruitment of leukocytes during murine visceral leishmaniasis." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321966.

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18

Bromley, Elizabeth Verity. "Characterisation of a novel protein belonging to the WD repeat family in the protozoan parasite Trypanosoma cruzi." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289740.

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19

Joyce-Menekse, Miranda Elizabeth. "Synthesis of novel azasteroids and azastilbenes as potential inhibitors of 24-methyltransferase." Thesis, Cardiff University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344021.

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20

Hay, Alayna Nicole. "Equine Protozoal Myeloencephalitis: investigating immunopathogenesis and treatment efficacy in mouse models and clinically affected horses." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/96373.

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Equine protozoal myeloencephalitis (EPM), predominantly caused by the protozoa Saracocystis neurona, is a common neurologic disease in horses from North America. Equine exposure to the parasite occurs frequently as the protozoa is excreted in opossum (Didelphis virginiana) feces and contaminates the horse's environment. However, clinical neurologic disease only emerges in a small fraction of exposed horses. The seemingly protective immune response that develops in some exposed horses but not all is not fully defined. Previous reports utilizing horse EPM models and immune compromised mouse mode

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21

Ben, Younes Chennoufi Amena. "Etude immunopathologique des lésions neuromusculaires de la maladie de Chagas expérimentale de la souris." Paris 6, 1986. http://www.theses.fr/1986PA066216.

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22

Rodrigues, Daniela Almeida. "MÉTODO PARA ENUMERAÇÃO DE OVOS DE HELMINTOS E OOCISTOS DE PROTOZOÁRIOS NA RIZOSFERA DE UMA MACRÓFITA." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/7648.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Brazil has a sanitation service with greater deficit coverage, this factor, related to water pollution that receives the discharge of effluents untreated, mainly from domestic sources, as the collection and treatment do not exist or are inadequate. Discharging effluents directly into the ground without proper treatment can lead to contamination of water resources, soil and groundwater, according to local characteristics. Amid this reality, the degradation of natural resources on the campus of UFSM, due to increased academic populat

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23

RIBEIRO, ROSANGELA do S. P. "Incidencia e epidemiologia da Leishmaniose visceral no norte do Tocantins." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9611.

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PARTATA, ANETTE K. "Epidemiologia da Leishmaniose visceral humana em Araguaia (TO) e o diagnostico sorologico da doenca." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11532.

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25

BORBOREMA, SAMANTA E. T. "Desenvolvimento e farmacocinetica de antimonio encapsulado em lipossomas de fostatidilserina utilizando radioisotopos em leishmaniose experimental." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9537.

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26

Pardini, Anne Dale. "The pathology and pathogenesis of canine cerebral babesiosis." Diss., University of Pretoria, 2000. http://hdl.handle.net/2263/27842.

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The pathology of canine cerebral babesiosis was examined at the gross, histological and ultrastructural levels. Gross lesions could be categorised as either global or regional. Congestive brain swelling , diffuse cerebral congestion and diffuse cerebral pallor were classified as global lesions. Multifocal haemorrhage and malacia were classified as regional lesions. Oedema was inconsistently present and could be either focal or diffuse. The majority of histological changes were observed in both cerebral babesiosis and control cases. Regional lesions were unique to cerebral babesiosis and

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27

GALISTEO, JUNIOR ANDRES J. "Toxoplasma gondii vs radiacao ionizante: estudo da imunidade intestinal em camundongos C57Bl/6j experimentalmente vacinados com taquizoitos irradiados." reponame:Repositório Institucional do IPEN, 2004. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11255.

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Ochaya, Stephen O. "Mapping the genome and characterization of an acetyltransferase of Trypanosoma cruzi /." Stockholm, 2006. http://diss.kib.ki.se/20060523/ocha/.

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SILVA, ANDREIA dos S. "Investigação de interações hiperfinas em DNA e anticorpos de diferentes linhagens de camundongos frente à infecção por T. cruzi pela epectroscopia de correlação angular gama-gama perturbada." reponame:Repositório Institucional do IPEN, 2012. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10117.

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Gautam, Ablesh. "EXAMINATION OF THE SNSAG SURFACE ANTIGEN GENE FAMILY IN SARCOCYSTIS NEURONA." UKnowledge, 2014. http://uknowledge.uky.edu/gluck_etds/20.

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Sarcocystis neurona is a protozoan parasite that causes the serious neurologic disease equine protozoal myeloencephalitis (EPM). The life cycle of S. neurona progresses through multiple developmental stages that differ morphologically and molecularly. The S. neurona merozoite surface is covered by multiple related proteins, which are orthologous to the surface antigen (SAG) gene family of Toxoplasma gondii. The SAG surface antigens in T. gondii and another related parasite Neospora caninum are life cycle stage-specific and seem necessary for parasite transmission and persistence of infection.

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Lobato, J?nior Wellington Sena. "Protozo?rios de vida livre em dois trechos da bacia hidrogr?fica do Rio Pirangi (RN): rela??es com a educa??o em ci?ncias e preserva??o." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18238.

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32

Molina, Julia Pereira 1985. "Caracterização da infecção por tripanossomatídeos (Protozoa: Kinetoplastida) presentes em três espécies de cascudo (Pisces: Loricariidae) do Rio Mogi-Guaçu, SP." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/315169.

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Orientador: Marlene Tiduko Ueta<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-17T04:30:52Z (GMT). No. of bitstreams: 1 Molina_JuliaPereira_M.pdf: 1442066 bytes, checksum: e8ad2a162950fbe267341b74c08ad0f7 (MD5) Previous issue date: 2010<br>Resumo: Os tripanossomas já foram reportados em diversas espécies de peixes de água salgada e doce, sendo a maioria das espécies descritas com base nas características morfológicas. Tripanossomas parasitos de peixes são heteroxenos e são transmitidos por hirudíneos. Este trabalho

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33

Branche, Carole. "Genome characterisation and mobility investigation in trypanosomes /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-682-4/.

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Pereira, Mirna Aparecida. "Ocorrencia de Cryptosporidium spp. e Giardia spp. em hortaliças da região metropolitana de Campinas (SP) : sua relação com a comunidade de trabalhadores e com a area agricola." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/315591.

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Orientador: Regina Maura Bueno Franco<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-10T17:55:42Z (GMT). No. of bitstreams: 1 Pereira_MirnaAparecida_D.pdf: 2261433 bytes, checksum: 8a2057547b84881643df7c062530dc1e (MD5) Previous issue date: 2008<br>Resumo: Cryptosporidium spp. e Giardia spp. são parasitos causadores de gastroenterites destacando se pela elevada incidência de casos, características de resistência aos tratamentos químicos e capacidade de permanência no meio ambiente. O importante papel desses protozoários

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OLIVEIRA, MARIA J. A. de. "Obtenção de membranas de hidrógeis para tratamento alternativo da Leishmaniose tegumentar." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10511.

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Millet, Pascal. "Développement, en culture cellulaire, de quelques Coccidiomorphes (Isopora, Plasmodium) : mise au point d'un modèle expérimental pour la chimiothérapie du paludisme." Paris 6, 1986. http://www.theses.fr/1986PA066272.

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Andrade, Elisabeth Campos de. "Ensaio clínico randomizado da nitazoxanida no tratamento de poliparasitoses intestinais em municípios da Zona da Mata, Minas Gerais." Universidade Federal de Juiz de Fora (UFJF), 2009. https://repositorio.ufjf.br/jspui/handle/ufjf/3946.

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LE, COZ SERGE. "La rhizomanie de la betterave sucriere : multiplication du virus et aspects agronomiques de la maladie." Paris 6, 1986. http://www.theses.fr/1986PA066644.

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Les chloroplastes des feuilles de betteraves rhizomaniees sont appauvries en pigments, en proteines, en liquides polaires et leur activite photosynthetique est reduite. Dans les cellules virosees, l'etude ultrastructure montre une association des amas de virus avec le reticulum endoplasmique granuleux. Un protocole pour la preparation de suspensions enrichies en cytosores isoles de polymyxa betae est propose. Le champignon est retrouve a tous les niveaux du sol de quatre parcelles rhizomaniees ou saines de la region de pithiviers. Une terre rhizomaniee reste infectieuse aprese un an et demi de

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Hawkesford, T. "Diagnosis, epidemiology and human immune response to cryptosporidiosis." Thesis, 1989. https://eprints.utas.edu.au/20297/7/whole_HawkesfordTiina1989.pdf.

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The protozoan parasite Cryptosporidium is now widely accepted as a cause of human gastroenteritis. The apparent lack of host specificity and the ability of the organism to undergo its entire life-cycle within the one host has important epidemiological implications. Studies here in Australia and in many other countries have shown Cryptosporidium to be an important pathogenic agent in gastroenteritis with an increased incidence in children, a strong rural connection and a possible seasonal trend in some places. The results of this study show that there are simple and sensitive methods

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40

Ferreira, Maryke Louise. "Systematics and ecology of Australian and South African gnathiid isopods, with observations on blood-inhabiting Protozoa found in some of their host fishes." Thesis, 2011. http://hdl.handle.net/10210/3766.

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M.Sc.<br>In this research project, a variety of sites and ecosystems were studied. These ranged from tropical coral reefs (north-eastern Coast of Australia), to warm temperate intertidal pools (South Coast of South Africa, SA) and sub-tropical estuaries (East Coast of SA). The overall aims of the thesis were to examine the haematophagous gnathiid ectoparasites and blood protozoans of some host teleosts found in these systems, and to some extent to investigate the role gnathiids might play as vectors of the protozoans. Gnathiid research in Australia on the Great Barrier Reef (GBR) focuses mainl

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Cloete, Yolandi Clignet. "The characterization of an intracellular protozoan parasite infecting the digestive gland of abalone, Haliotis midae." Thesis, 2010. http://hdl.handle.net/10210/3210.

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M.Sc.<br>Abalone are among the world’s leading shellfish consumed by human populations. Harvesting in California began in the late 1800s from intertidal zones and in the early 1900s wild abalone were collected by diving. Popular demand for abalone products in the Far East then led to extensive harvesting of wild abalone and a drastic decline in population numbers. This problem was overcome to a degree by the development of land-based abalone farms. At these farms it was possible to breed abalone on a large scale. Currently twelve abalone farms operate in South Africa and the estimated producti

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DI, CHIO Carla. "Design, synthesis and biological evaluation of novel bioactive molecules for the treatment of protozoan and human diseases." Doctoral thesis, 2021. http://hdl.handle.net/11570/3214296.

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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PSEUDOPEPTIDES AS INHIBITORS OF RHODESAIN OF T. brucei rhodesiense Human African Trypanosomiasis (HAT) is caused by a protozoan of Trypanosoma genus. There are two forms of HAT, the chronic form caused by Trypanosoma brucei gambiense and the acute form caused by Trypanosoma brucei rhodesiense. This infection is transmitted to humans by the bite of a fly belonging to Glossina genus (tsetse fly). There is an urgent need to find new targets for HAT treatment because current therapy shows many problems. In this research area, rhodesain, a cyst

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Roy, Nainita. "Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases." Thesis, 2011. https://etd.iisc.ac.in/handle/2005/1965.

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Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated machinery called chaperones to enable protein folding. One class of these chaperones is heat shock proteins named so because they were initially discovered to be heat inducible and particularly important during heat stress. However the role of heat shock proteins has now been extended from merely being important for stress tolerance. Heat shock proteins are prominently involved

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Roy, Nainita. "Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases." Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/1965.

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Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated machinery called chaperones to enable protein folding. One class of these chaperones is heat shock proteins named so because they were initially discovered to be heat inducible and particularly important during heat stress. However the role of heat shock proteins has now been extended from merely being important for stress tolerance. Heat shock proteins are prominently involved

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Kwitshana, Zilungile L. "In vitro culture and isoenzyme analysis of giardia lamblia." Thesis, 1999. http://hdl.handle.net/10413/8226.

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Giardia lamblia, an enteric protozoan parasite, infects a large number of individuals worldwide. In South Africa prevalences ranging between 4 and 63% are documented, however, the impact of giardiasis is underreseached in this country. Giardia infections vary from asymptomatic carriage or a self-limiting acute symptomatic illness to chronic, debilitating malabsorption syndrome. The factors responsible for development of symptomatic versus asymptomatic infection are poorly understood. It is believed by some that host factors determine the clinical outcome of infection. On the other hand, the po

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"Biodiversity and systematics of apicomplexan parasites infecting South African leopard and hinged tortoises." Thesis, 2010. http://hdl.handle.net/10210/3081.

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M.Sc.<br>Research into blood protozoans (haematozoans) infecting African tortoises is scanty with only a few records published, many during the early part of the last century. Little research had been done on the blood parasites of tortoises examined in this study namely, Kinixys lobatsiana, K. belliana belliana, K. natalensis, Geochelone pardalis pardalis, G. pardalis babcocki and Chersina angulata. The study therefore aimed to: 1) examine apicomplexan haematozoan parasites infecting several of South Africa’s indigenous tortoises and compare them with published species descriptions, especiall

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Stilger, Krista L. "Identification of TgElp3 as an essential, tail-anchored mitochondrial lysine acetyltransferase in the protozoan pathogen toxoplasma gondii." Thesis, 2014. http://hdl.handle.net/1805/4660.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Toxoplasma gondii, a single-celled eukaryotic pathogen, has infected one-third of the world’s population and is the causative agent of toxoplasmosis. The disease primarily affects immunocompromised individuals such as AIDS, cancer, and transplant patients. The parasites can infect any nucleated cell in warm-blooded vertebrates, but because they preferentially target CNS, heart, and ocular tissue, manifestations of infection often include encephalitis, myocarditis, and a host of neurological and ocular disorders. Toxoplasma can also b

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Makumire, Stanley. "Investigation of the role of the GGMP motif of Plasmodium falciparum Hsp70-1 on the chaperone function of the protein and its interaction with a co-chaperone, PfHop." Thesis, 2019. http://hdl.handle.net/11602/1436.

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PhD (Biochemistry)<br>Department of Biochemistry<br>The main malaria agent, Plasmodium falciparum expresses an Hsp70 (PfHsp70-1) which plays a significant role in parasite survival. PfHsp70-1 is distinct in that it possesses glycine-glycine-methionine-proline (GGMP) tetrapeptide repeats in its C-terminal domain. To date, the GGMP motif of PfHsp70-1 has not been studied. The motif is positioned within the C-terminal lid segment of PfHsp70-1. The motif is also about seven residues upstream the terminal EEVD residues that are responsible for the interaction of PfHsp70-1 with its functional regula

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Lebepe, Charity Mekgwa. "Comparative analysis of a chimeric Hsp70 of E. coli and Plasmodium falciparum origin relative to its wild type forms." Diss., 2018. http://hdl.handle.net/11602/1360.

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MSc (Biochemistry)<br>Department of Biochemistry<br>Sustaining proteostasis is essential for the survival of the cell and altered protein regulation leads to many cellular pathologies. Heat shock proteins (Hsps) are involved in the regulation of the protein quality control. Hsps are a group of molecular chaperones that are upregulated in response to cell stress and some are produced constitutively. The Hsp70 family also known as DnaK in Escherichia coli (E. coli) is the most well-known group of molecular chaperones. Structurally, Hsp70s consist of a nucleotide binding domain (NBD) and a substr

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Mabate, Blessing. "Exploration of interaction between Plasmodium falciparum Hsp70-x (PfHsp70-x) and human Hsp70-Hsp90 organizing protein (human Hop)." Diss., 2017. http://hdl.handle.net/11602/934.

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MSc (Biochemistry)<br>Department of Biochemistry<br>Malaria is a disease that claims about half a million lives annually, mainly children. There are 5 Plasmodium species that cause malaria; namely, P. falciparum, P. ovale, P. malariae, P. knowlesi and P. vivax. P. falciparum is the most virulent of them all. The parasite upregulates some heat shock proteins (Hsps) in response to stress it encounters during its life cycle. These Hsps play a major role in proteostasis. The drug resistance of P. falciparum to traditionally used remedies has led to a need for the development of novel drugs. Hsps h

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