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Artykuły w czasopismach na temat „PRRS-V”

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Data publikacji: 19 grudnia 2024

Data aktualizacji: 31 lipca 2025

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1

Kosinova, E., and I. Psikal. "Restriction fragment length polymorphism of ORF6 and ORF7 genes of porcine reproductive and respiratory syndrome virus (PRRSV) vaccine strains registered in the CzechRepublic." Veterinární Medicína 51, No. 8 (2012): 414–22. http://dx.doi.org/10.17221/5565-vetmed.

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Restriction fragment length polymorphism (RFLP) of open reading frames 6 and 7 was applied to comparative genetic analysis of live attenuated vaccine strains (Amervac-PRRS/A3, Porcilis PRRS, Ingelvac PRRS) of porcine reproductive and respiratory syndrome virus (PRRSV), registered in the Czech Republic, six field viruses (L-588, L-1606, L-2053, L-3305, L-6558, L-6791), and three PRRSV local field isolates (CAMP V-502, CAMP V-503, VOS 2878) found in pig herds in the Czech Republic and Slovak Republic. The set of restriction enzymes Hae II, Alu I and BsaJ I allowed the differentiation of local fi

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Bertram, Mark J., Steve J. Kitt, and Keith Kinsely. "PSVI-14 Impact of Bacillus Subtilis and Bacillus Licheniformis on Weaning Weight and Subsequent Performance, Health and Immune Parameters When Challenged with PRRSV with and Without PRRS Vaccination." Journal of Animal Science 100, Supplement_2 (2022): 160–61. http://dx.doi.org/10.1093/jas/skac064.274.

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Abstract A study was conducted examining the impact of feeding BioPlus 2B to PRRSV naïve sows during gestation and lactation on litter performance and on post-weaning performance when challenged with PRRSV in vaccinated and unvaccinated pigs. A total of 108 sows were allotted by parity and received a control diet (C) or BioPlus 2B (B2B) supplemented diet beginning a minimum of 31 d prior to farrowing through weaning. Pig weight was measured at birth and 17 d of age. At weaning, a subset of 200 pigs from each treatment were transported to a nursery and randomly allotted within dietary treatment

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3

Indik, S., and L. Valíček. "Differentiation of porcine reproductive and respiratory syndrome virus European vaccine strains from Czech field isolates by restriction fragment length polymorphism analysis of ORF5 gene." Veterinární Medicína 47, No. 10 - 11 (2012): 295–301. http://dx.doi.org/10.17221/5838-vetmed.

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Restriction fragment length polymorphism (RFLP) analysis of open reading frame 5 was developed for typing of Czech strains of porcine reproductive and respiratory syndrome virus (PRRSV). The set of restriction enzymes Acc I, Hae II and SnaB I allowed the differentiation of heterogeneous Czech strains of PRRSV clustered separately in the phylogenetic tree. The high-passage strain V-502 (164) was also differentiated from its parent strain V-502. The same restriction enzymes could distinguish the European-type vaccine strains Porcilis PRRS and Pyrsvac-183, registered inCzechRepublic, from the Cze

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4

Torricelli, Martina, Anna Fratto, Marcella Ciullo, et al. "Porcine Reproductive and Respiratory Syndrome (PRRS) and CD163 Resistance Polymorphic Markers: What Is the Scenario in Naturally Infected Pig Livestock in Central Italy?" Animals 13, no. 15 (2023): 2477. http://dx.doi.org/10.3390/ani13152477.

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Porcine Reproductive and Respiratory Syndrome (PRRS) caused by the PRRS virus affects farmed pigs worldwide, causing direct and indirect losses. The most severe manifestations of PRRS infection are observed in piglets and pregnant sows. The clinical outcome of the infection depends on the PRRSV strain’s virulence, the pregnancy state of the female, environmental factors, the presence of protective antibodies due to previous infections, and the host’s genetic susceptibility. The latter aspect was investigated in this study, in particular, evaluating the most significant polymorphisms (SNPs) of

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5

Wilcock, Pete, Kiah M. Berg, Gustavo Cordero, and Anthony Russo. "PSII-14 The Effect of Increasing Soluble Dietary Fiber and the Addition of a Stimbiotic in Gestation on Sow Productivity in a Prrs and Non-Prrs Challenge." Journal of Animal Science 101, Supplement_2 (2023): 290–91. http://dx.doi.org/10.1093/jas/skad341.331.

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Abstract This sow study evaluated the effect that sugar beet pulp (SBP), a soluble fiber source, and a stimbiotic (Signis; AB Vista) can have on sow productivity and health when fed in gestation. A stimbiotic is an additive that stimulates fiber-degrading microbiome, resulting in an increase in fiber fermentability even though the additive itself contributes limited small chain fatty acid production. A commercial gestation barn with two feeding lines was utilized to feed sows (n = 2173) two dietary treatments from d 30 to d 90; a corn, soy, soy hulls with (HSDF) or without (LSDF) SBP (50 kg/t)

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6

ROLINEC, Michal, Daniel Bíro, Branislav Gálik, Milan Šimko, and Miroslav Juráček. "IMMUNOGLOBULINS IN COLOSTRUM OF SOWS WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - PRRS." Journal of Central European Agriculture 13, no. 2 (2012): 301–8. http://dx.doi.org/10.5513/jcea01/13.2.1049.

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7

Graham, Simon P., Yuen-Ki Cheong, Summer Furniss, et al. "Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virus." Nanomaterials 11, no. 8 (2021): 2120. http://dx.doi.org/10.3390/nano11082120.

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Porcine reproductive and respiratory syndrome viruses (PRRSV) are responsible for one of the most economically important diseases affecting the global pig industry. On-farm high-efficiency particulate air (HEPA) filtration systems can effectively reduce airborne transmission of PRRSV and the incidence of PRRS, but they are costly, and their adoption is limited. Therefore, there is a need for low-cost alternatives, such as antimicrobial filters impregnated with antiviral nanoparticles (AVNP). During the past 10 years, tailored intermetallic/multi-elemental AVNP compositions have demonstrated ef

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8

Kyutoku, Fumiaki, Takashi Yokoyama, and Katsuaki Sugiura. "Genetic Diversity and Epidemic Types of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus in Japan from 2018 to 2020." Epidemiologia 3, no. 2 (2022): 285–96. http://dx.doi.org/10.3390/epidemiologia3020022.

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To clarify the genetic diversity of the porcine reproductive and respiratory syndrome virus (PRRSV) in Japan in recent years, we determined the nucleotide sequence of open reading frame 5 of 2482 PRRSV sequences obtained from samples collected from pigs between January 2018 and December 2020. As a result of molecular phylogenetic analysis, Cluster II represented the largest proportion (44.9–50.6%) throughout the study period, followed by Cluster IV (34.0–40.8%), Cluster III (7.8–12.1%), Cluster I (3.1–6.7%), and Cluster V (0.1–0.2%). The relative distributions between Clusters varied between g

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9

Liu, Wenguang, Bing Liu, Gege Zhang, et al. "Molecular and Functional Characterization of a Short-Type Peptidoglycan Recognition Protein, Ct-PGRP-S1 in the Giant Triton Snail Charonia tritonis." International Journal of Molecular Sciences 23, no. 19 (2022): 11062. http://dx.doi.org/10.3390/ijms231911062.

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Peptidoglycan recognition proteins (PGRPs) are a family of pattern recognition receptors (PRRs) involved in host antibacterial responses, and their functions have been characterized in most invertebrate and vertebrate animals. However, little information is available regarding the potential function of PGRPs in the giant triton snail Charonia tritonis. In this study, a short-type PGRP gene (termed Ct-PGRP-S1) was identified in C. tritonis. Ct-PGRP-S1 was predicted to contain several structural features known in PGRPs, including a typical PGRP domain (Amidase_2) and Src homology-3 (SH3) domain.

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10

Yoshino, Hironori, and Ikuo Kashiwakura. "Beneficial Effects Of Ionizing Radiation To Enhance Anti-Cancer Effects Of RIG-Like Receptor Stimulus." Blood 122, no. 21 (2013): 4721. http://dx.doi.org/10.1182/blood.v122.21.4721.4721.

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Introduction The immune system is composed of innate and adaptive immunity. Antigen presenting cells (APCs), such as macrophages and dendritic cells, serve as a link between innate and adaptive immunity. Furthermore, APCs express pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns. Retinoic acid-inducible gene-I (RIG-I)-like receptors [RLRs; RIG-I and melanoma differentiation-associated gene 5 (MDA5)] are a type of PRRs and sense virus-derived RNA or a synthetic analog of dsRNA polyinosinic-polycytidylic acid [poly(I:C)]. Although macrophages are resistant to

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11

Yeske, Paul. "41 Is there anything we can do to lessen the severity of PRRSv?" Journal of Animal Science 102, Supplement_2 (2024): 235–36. http://dx.doi.org/10.1093/jas/skae102.268.

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Abstract Veterinarians and the swine industry continue to battle PRRS virus (v), as demonstrated by both the MSHMP (Morrison Swine Health Monitoring Project) and the SDRS (Swine Disease Reporting System). Both systems depict a continued increase in PRRSv prevalence and percentage of positive cases. The PRRSv variants that are circulating today seem to be more severe, especially in the last 2 to 3 yr, with more significant health and production losses in the nursery and finishing phases for prolonged periods of time. The best thing that can be done is to avoid having the virus with a good bioex

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12

Modak, Tejashree H., and Marta Gomez-Chiarri. "Contrasting Immunomodulatory Effects of Probiotic and Pathogenic Bacteria on Eastern Oyster, Crassostrea Virginica, Larvae." Vaccines 8, no. 4 (2020): 588. http://dx.doi.org/10.3390/vaccines8040588.

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Several Vibrio spp. cause acute and severe mortality events in hatcheries where larvae of bivalve mollusks are reared, potentially leading to subsequent shortage of bivalve seed for the grow-out industry. In particular, strains of Vibrio coralliilyticus have been identified as a major cause of disease in Pacific, Crassostrea gigas, and eastern, C. virginica, oyster hatcheries in the USA of America. Probiotic bacteria are an inexpensive, practical, and natural method of disease control. Previous research shows that pretreatment of larval oysters with probiotic bacteria Bacillus pumilus RI06–95

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13

Arepally, Gowthami M., Rui Qi, John Hollingsworth, and Shayela Suvarna. "Determinants of PF4/Heparin Immunogenicity in a Murine Model of HIT." Blood 108, no. 11 (2006): 96. http://dx.doi.org/10.1182/blood.v108.11.96.96.

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Abstract Heparin-Induced Thrombocytopenia (HIT) is a life-threatening immune-mediated reaction caused by platelet factor 4 (PF4)/heparin complexes. In recent in vitro studies, we have shown that human and monoclonal HIT antibodies recognize and optimally bind to ultra-large complexes (ULC; MW&gt;670kDa) formed at equimolar ratios of PF4 and heparin. We undertook the following studies to determine if the in vivo immunogenicity of PF4/heparin complexes showed similar requirements for stoichiometric molar ratios of PF4:heparin (PHR). Using a previously described murine immunization model, mic

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14

Wang, Jingjing, Zhaohai Du, Xuehan Huo, et al. "Genome-wide analysis of PRR gene family uncovers their roles in circadian rhythmic changes and response to drought stress in Gossypium hirsutum L." PeerJ 8 (September 25, 2020): e9936. http://dx.doi.org/10.7717/peerj.9936.

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Background The circadian clock not only participates in regulating various stages of plant growth, development and metabolism, but confers plant environmental adaptability to stress such as drought. Pseudo-Response Regulators (PRRs) are important component of the central oscillator (the core of circadian clock) and play a significant role in plant photoperiod pathway. However, no systematical study about this gene family has been performed in cotton. Methods PRR genes were identified in diploid and tetraploid cotton using bioinformatics methods to investigate their homology, duplication and ev

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15

Afzal, Muhammad Amin, Farrukh Azeem, Shumaila Afzal, et al. "Comparative Omics-Based Identification and Expression Analysis of a Two-Component System in Vigna radiata in Drought Stress." Agronomy 13, no. 4 (2023): 989. http://dx.doi.org/10.3390/agronomy13040989.

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Two-component system (TCS) genes regulate a wide range of biological activities in prokaryotes and eukaryotes, including plants. TCS plays an important role in cellular responses to external stimuli, such as biotic and abiotic factors. In plants, this system supports cell division, leaf senescence, stress response, chloroplast division, and nutrient signaling. There are three kinds of proteins responsible for the appropriate functioning of the TCS system: histidine kinases (HKs), histidine phosphotransfer proteins (HPs), and response regulators (RRs). The results of the current study revealed

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16

Pavlakis, Nick, David Turner Ransom, David Wyld, et al. "Australasian Gastrointestinal Trials Group (AGITG) CONTROL NET Study: Phase II study evaluating the activity of 177Lu-Octreotate peptide receptor radionuclide therapy (LuTate PRRT) and capecitabine, temozolomide CAPTEM)—First results for pancreas and updated midgut neuroendocrine tumors (pNETS, mNETS)." Journal of Clinical Oncology 38, no. 15_suppl (2020): 4608. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.4608.

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4608 Background: CAPTEM is an accepted regimen for patients (pts) with advanced pNETs. Single agent 177Lu-Octreotate PRRT is now a standard of care for progressive WHO Grade (G) 1/2 mNETs. High activity was seen with LuTate/CAPTEM in a single arm Phase I/II trial. This study was undertaken to determine the relative activity of adding CAPTEM to LuTate PRRT in pts with mNETs and pNETs. Methods: Non-comparative randomised open label parallel group phase II trial with 2:1 randomisation to PRRT/CAPTEM (experimental arm) vs. PRRT (mNETs control) and CAPTEM (pNETS control). PRRT/CAPTEM: 7.8GBq LuTate

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17

Li, Chunlin, Jin Cui, Hui Zheng та ін. "The NADC30-like PRRSV activates the integrin αV subunit to facilitate its entry into Marc-145 cells". PLOS ONE 20, № 3 (2025): e0316239. https://doi.org/10.1371/journal.pone.0316239.

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Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus that poses a significant threat to the global pig farming industry, resulting in substantial economic losses. However, owing to the high variability of PRRSV and unclear mechanisms of infection, there are currently no effective vaccines or drugs available for its prevention and control. Our previous report revealed that highly pathogenic PRRSV (HP-PRRSV) requires the FAK-PI3K-AKT signaling pathway to facilitate its entry into cells. In this study, we further investigated whether the integrin subunit was in

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18

Ullah, Shaukat, Hikmat Ullah, Kainat Fatima, and Tan Lei. "In Silico Designed Multi-Epitope Vaccine Based on the Conserved Fragments in Viral Proteins for Broad-Spectrum Protection Against Porcine Reproductive and Respiratory Syndrome Virus." Veterinary Sciences 12, no. 6 (2025): 577. https://doi.org/10.3390/vetsci12060577.

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Porcine reproductive and respiratory syndrome virus (PRRSV) is a major viral threat to swine, causing significant economic loss in the global pig farming industry. This virus includes two major genotypes, PRRSV1 and PRRSV2, both characterized by high mutation rates and genetic variability, complicating the development of a universally effective vaccine and disease control. To address this challenge, this study utilizes immunoinformatics tools to identify conserved epitopes and design a multi-epitope vaccine candidate against PRRSV based on reverse vaccinology. The complete sequences of PRRSV-e

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19

Pavlakis, Nick, David Turner Ransom, David Wyld, et al. "First results for Australasian Gastrointestinal Trials Group (AGITG) control net study: Phase II study of 177Lu-octreotate peptide receptor radionuclide therapy (LuTate PRRT) +/- capecitabine, temozolomide (CAPTEM) for midgut neuroendocrine tumors (mNETs)." Journal of Clinical Oncology 38, no. 4_suppl (2020): 604. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.604.

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604 Background: Single agent 177Lu-octreotate peptide receptor radionuclide therapy is now a standard of care for progressive mNETS. High activity was seen with LuTate and concurrent CAPTEM chemotherapy in a single arm Phase I/II trial. This study was undertaken to determine the relative activity of adding CAPTEM to LuTate PRRT in patients with mNETs. Methods: Non-comparative randomised open label phase II trial of PRRT +/- CAPTEM in patients with mNETs, with 2:1 randomisation: PRRT /CAPTEM (experimental arm) vs. PRRT (control). PRRT /CAPTEM: 7.8GBq LuTate day(D) 10, 8 weekly (wkly) x 4, with

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20

Reymond, Nicolas, Stéphanie Fabre, Eric Lecocq, José Adelaı̈de, Patrice Dubreuil, and Marc Lopez. "Nectin4/PRR4, a New Afadin-associated Member of the Nectin Family That Trans-interacts with Nectin1/PRR1 through V Domain Interaction." Journal of Biological Chemistry 276, no. 46 (2001): 43205–15. http://dx.doi.org/10.1074/jbc.m103810200.

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Cao, Zong-Xi, Pei-Rong Jiao, Yu-Mao Huang, et al. "Genetic diversity analysis of the ORF5 gene in porcine reproductive and respiratory syndrome virus samples from South China." Acta Veterinaria Hungarica 60, no. 1 (2012): 157–64. http://dx.doi.org/10.1556/avet.2012.013.

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To understand the genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) in South China, we collected 231 clinical samples from pigs with suspected PRRSV infection in Guangdong between 2007 and 2009. We found that 74 of 231 samples were positive by RT-PCR. The PCR products of the ORF5 gene of 35 isolates from different farms were sequenced and their DNA sequences were compared to 23 other PRRSV isolates in the GenBank. We found that the nucleotide similarity among all South China isolates ranged from 87.6% to 100%, and all belonged to the North American genotype. Most

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Lopez, Marc, Mustapha Aoubala, François Jordier, Daniel Isnardon, Sophie Gomez, and Patrice Dubreuil. "The Human Poliovirus Receptor Related 2 Protein Is a New Hematopoietic/Endothelial Homophilic Adhesion Molecule." Blood 92, no. 12 (1998): 4602–11. http://dx.doi.org/10.1182/blood.v92.12.4602.424k21_4602_4611.

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We have recently described Poliovirus Receptor Related 2 (PRR2), a new cell surface molecule homologous to the poliovirus receptor (PVR/CD155). Both molecules are transmembrane glycoproteins belonging to the Ig superfamily (IgSF). They contain 3 Ig domains of V, C2, and C2 types in their extracellular regions that share 51% aa identity. The PRR2 gene encodes two mRNA isoforms of 3.0 kb (hPRR2 [short form]) and 4.4 kb (hPRR2δ [long form]), both widely expressed in human tissues, including hematopoietic cells. To further characterize PRR2 expression during hematopoiesis and to analyze its funct

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Indik, Stanislav, Lubomír Valíček, Dieter Klein, and Jana Klánová. "Variations in the major envelope glycoprotein GP5 of Czech strains of porcine reproductive and respiratory syndrome virus." Journal of General Virology 81, no. 10 (2000): 2497–502. http://dx.doi.org/10.1099/0022-1317-81-10-2497.

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The major envelope glycoprotein genes (ORF5) of seven Czech isolates of porcine reproductive and respiratory syndrome virus (PRRSV) were amplified and their nucleotide sequences were determined. ORF5 displayed nucleotide and amino acid identities of 87·5–100% and 87·6–100%, respectively, among the isolates. In a phylogenetic tree, all European isolates were grouped in a genotype distinct from that of reference American strains (VR-2332, IAF-Klop). Among the European isolates, two different clades were identified. Two Czech isolates (V-501 and V-503) and Italian strain PRRSV 2156 fell into one

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Lopez, Marc, Mustapha Aoubala, François Jordier, Daniel Isnardon, Sophie Gomez, and Patrice Dubreuil. "The Human Poliovirus Receptor Related 2 Protein Is a New Hematopoietic/Endothelial Homophilic Adhesion Molecule." Blood 92, no. 12 (1998): 4602–11. http://dx.doi.org/10.1182/blood.v92.12.4602.

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Abstract We have recently described Poliovirus Receptor Related 2 (PRR2), a new cell surface molecule homologous to the poliovirus receptor (PVR/CD155). Both molecules are transmembrane glycoproteins belonging to the Ig superfamily (IgSF). They contain 3 Ig domains of V, C2, and C2 types in their extracellular regions that share 51% aa identity. The PRR2 gene encodes two mRNA isoforms of 3.0 kb (hPRR2 [short form]) and 4.4 kb (hPRR2δ [long form]), both widely expressed in human tissues, including hematopoietic cells. To further characterize PRR2 expression during hematopoiesis and to analyze

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Crisci, Elisa, Andrew R. Kick, Lizette M. Cortes, et al. "Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex." Vaccines 13, no. 7 (2025): 740. https://doi.org/10.3390/vaccines13070740.

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Background/Objectives: The porcine respiratory disease complex (PRDC) is a multifaceted, polymicrobial syndrome resulting from a combination of environmental stressors, primary infections (e.g., PRRSV) and secondary infectious agents (viruses and bacteria). PRDC causes severe lung pathology, leading to reduced performance, increased mortality rates, and higher production costs in the global pig industry. Our goal was to conduct a comprehensive study correlating both the anti-PRRSV immune response and 21 secondary infectious agents with PRDC severity. Methods: To this end, PRRSV-negative weaner

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Nemec, James M., and Paweł Moskalik. "Four ‘Peculiar’ RRd stars observed by K2." Monthly Notices of the Royal Astronomical Society 507, no. 1 (2021): 781–802. http://dx.doi.org/10.1093/mnras/stab1929.

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ABSTRACT Four stars pulsating simultaneously with a dominant period PD ∈ (0.28, 0.39) d and an additional period PA ∈ (0.20, 0.27) d have been identified from among the more than 3000 RR Lyrae stars observed by the Kepler space telescope during NASA’s K2 Mission. All four stars are located in the direction of the Galactic Bulge and have period ratios, PA/PD, significantly smaller than those of most double-mode RR Lyrae (RRd) stars: PA/PD ∈ (0.694, 0.710) versus P1/P0 ∈ (0.726, 0.748). Three of the stars are faint (〈V〉 = 18–20 mag) and distant and are among the ‘peculiar’ RRd (pRRd) stars disco

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Harrison, Olivia, Haley Otott, Jianfa Bai, et al. "67 Decontamination of a feed manufacturing environment following inoculation of porcine epidemic diarrhea virus, porcine reproductive and respiratory virus, and Seneca Valley virus 1." Journal of Animal Science 102, Supplement_2 (2024): 46–47. http://dx.doi.org/10.1093/jas/skae102.055.

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Abstract Feed mill decontamination is difficult because equipment is not designed to be cleaned with water. Alternate strategies may improve the ability of a mill to decontaminate in the event of viral contamination. The objective was to evaluate different decontamination strategies within a mill following the inoculation of porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV), and Seneca Valley virus 1 (SVV1) contaminated feed. A batch of feed was inoculated with PEDV, PRRSV, and SVV1 and ran through a mixer, bucket elevator, corn cleaner, screw

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Harrison, Olivia, Catherine Grace Elijah, Allison K. Blomme, et al. "53 Evaluating the Efficacy of Boot Baths with Wet and Dry Disinfectants for Porcine Epidemic Diarrhea Virus and Porcine Reproductive and Respiratory Syndrome Virus." Journal of Animal Science 100, Supplement_2 (2022): 17–18. http://dx.doi.org/10.1093/jas/skac064.029.

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Abstract Maintaining biosecurity between barns is challenging. Boot baths, either wet or dry, can be implemented to limit pathogen spread. The objective was to evaluate the efficacy of boot baths using wet or dry disinfectants for porcine epidemic diarrhea virus (PEDV) and porcine reproductive and respiratory syndrome virus (PRRSV). Treatments included 1) control, 2) wet disinfectant (Synergize, Neogen, Lexington, KY), and 3) dry disinfectant (Traffic C.O.P., PSP, LLC, Rainsville, AL). Prior to disinfection, 0.5 mL of both PRRSV (~1×105 TCID50/mL) and PEDV (~1×105 TCID50/mL) was placed onto a

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Eddicks, Matthias, Lina Eddicks, Julia Stadler, Walter Hermanns, and Mathias Ritzmann. "Der Porcine Respiratory Disease Complex (PRDC) – eine klinische Übersicht." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 49, no. 02 (2021): 120–32. http://dx.doi.org/10.1055/a-1403-1976.

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ZusammenfassungDer Porcine Respiratory Disease Complex (PRDC) beschreibt eine klinische Kondition, die sich in Form einer häufig therapieresistenten Atemwegsinfektion bei Mastschweinen manifestiert. Die multifaktorielle Ätiologie beinhaltet infektiöse und nicht infektiöse Faktoren. Bei Entstehung und Verlauf des PRDC spielen neben Management und Hygiene v. a. virale und bakterielle Erreger eine bedeutende Rolle. Das Virus des Porzinen Reproduktiven und Respiratorischen Syndroms (PRRSV), das porzine Circovirus Typ 2 (PCV2), Influenza-A-Virus (IAV) und Mycoplasma (M.) hyopneumoniae stellen die r

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Gosewisch, Astrid, Harun Ilhan, Lena Vomacka, and Guido Böning. "Dosimetrie bei der Radionuklidtherapie mit Lu-177." Der Nuklearmediziner 41, no. 01 (2018): 69–80. http://dx.doi.org/10.1055/s-0043-122171.

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ZusammenfassungDie Radioligandentherapie (RLT) mit radioaktiv markierten PSMA-Liganden (z. B. Lu-177-PSMA-617) und die Peptid-Rezeptor-Radionuklidtherapie (PRRT) mit radioaktiv markierten Somatostatin-Analoga (z. B. Lu-177-DOTATATE) haben sich über die letzten Jahre als vielversprechende Therapieoptionen bei metastasierten, kastrationsresistenten Prostatakarzinomen bzw. inoperablen oder metastasierten neuroendokrinen Tumoren entwickelt. Das Theragnostiknuklid Lu-177 weist dabei neben der Therapie-relevanten Beta-Minus-Komponente eine, auch für die Bildgebung gut nutzbare, Gammaemission auf, di

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Krummenacher, Claude, Isabelle Baribaud, Manuel Ponce de Leon, et al. "Localization of a Binding Site for Herpes Simplex Virus Glycoprotein D on Herpesvirus Entry Mediator C by Using Antireceptor Monoclonal Antibodies." Journal of Virology 74, no. 23 (2000): 10863–72. http://dx.doi.org/10.1128/jvi.74.23.10863-10872.2000.

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ABSTRACT The human herpesvirus entry mediator C (HveC), also known as the poliovirus receptor-related protein 1 (PRR1) and as nectin-1, allows the entry of herpes simplex virus type 1 (HSV-1) and HSV-2 into mammalian cells. The interaction of virus envelope glycoprotein D (gD) with such a receptor is an essential step in the process leading to membrane fusion. HveC is a member of the immunoglobulin (Ig) superfamily and contains three Ig-like domains in its extracellular portion. The gD binding site is located within the first Ig-like domain (V domain) of HveC. We generated a panel of monoclona

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Martinez, Wanda M., and Patricia G. Spear. "Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry." Journal of Virology 75, no. 22 (2001): 11185–95. http://dx.doi.org/10.1128/jvi.75.22.11185-11195.2001.

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ABSTRACT One step in the process of herpes simplex virus (HSV) entry into cells is the binding of viral glycoprotein D (gD) to a cellular receptor. Human nectin-2 (also known as HveB and Prr2), a member of the immunoglobulin (Ig) superfamily, serves as a gD receptor for the entry of HSV-2, variant forms of HSV-1 that have amino acid substitutions at position 25 or 27 of gD (for example, HSV-1/Rid), and porcine pseudorabies virus (PRV). The gD binding region of nectin-2 is believed to be localized to the N-terminal variable-like (V) Ig domain. In order to identify specific amino acid sequences

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Domingues, Francisco, Olivia Harrison, Jianfa Bai, et al. "PSII-16 Evaluation of formaldehyde on complete feed when inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and Seneca Valley virus 1." Journal of Animal Science 103, Supplement_1 (2025): 290–91. https://doi.org/10.1093/jas/skaf102.323.

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Abstract Chemical mitigants have been found to decrease virus concentrations in feed. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in this matrix. Therefore, the objective was to evaluate different inclusion levels of formaldehyde when applied either before virus inoculation (pre-inoculation) or after inoculation (post-inoculation) of porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV) and Seneca Valley virus 1 (SVV1) to complete feed. The experiment was designed in a 2×2 fac

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HOU, Jie, Rui LI, Hongfang MA, Songlin QIAO, and Gaiping ZHANG. "Structural prediction of porcine sialoadhesin V-set Ig-like domain sheds some light on its role in porcine reproductive and respiratory syndrome virus (PRRSV) infection." Frontiers of Agricultural Science and Engineering 3, no. 1 (2016): 65. http://dx.doi.org/10.15302/j-fase-2016086.

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Chhajlani, Siddharth, Jelka Kuiper, Philippe Beutels, et al. "Somatostatin analogue continuation upon progression in patients with gastroenteropancreatic neuroendocrine tumour (SAUNA trial): a randomised controlled trial protocol." BMJ Open 15, no. 7 (2025): e099996. https://doi.org/10.1136/bmjopen-2025-099996.

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Introduction Gastroenteropancreatic neuroendocrine tumours (GEP NET) are malignant neoplasms that impact survival. Somatostatin analogues (SSA) are used for treating hormonal symptoms caused by GEP NET and have antiproliferative effects. They are used as first-line therapy in patients with advanced GEP NET, but disease control is limited to a median progression-free survival (mPFS) of 14–32 months. Second-line treatment options include targeted therapy (everolimus or sunitinib), or peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE. In patients suffering from a NET-related hormon

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Wannier, T., T. G. Deliagina, G. N. Orlovsky, and S. Grillner. "Differential Effects of the Reticulospinal System on Locomotion in Lamprey." Journal of Neurophysiology 80, no. 1 (1998): 103–12. http://dx.doi.org/10.1152/jn.1998.80.1.103.

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Wannier, T., T. G. Deliagina, G. N. Orlovsky, and S. Grillner. Differential effects of the reticulospinal system on locomotion in lamprey. J. Neurophysiol. 80: 103–112, 1998. Specific effects of stimulating different parts of the reticulospinal (RS) system on the spinal locomotor pattern are described in lamprey. In the in vitro brain stem and spinal cord preparation, microstimulation in different areas of the reticular formation was performed by ejecting a small amount of d-glutamate from a micropipette. These areas were distributed over the four reticular nuclei of the brain stem: the mesenc

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Sharma, Vishal, Surinder Singh Rana, and Deepak Kumar Bhasin. "Role of Endoscopic Ultrasound in Gastroenteropancreatic Neuroendocrine Tumors and Update on Their Treatment." Journal of Postgraduate Medicine, Education and Research 47, no. 1 (2013): 54–60. http://dx.doi.org/10.5005/jp-journals-10028-1056.

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ABSTRACT The gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare tumors and include all tumors arising from the gastrointestinal (GI) or pancreatic neuroendocrine cells. They can occur anywhere in the GI tract with the small intestine, pancreas and rectum being the common GI sites. Because of nonspecific symptoms they are difficult to diagnose and diagnosis is often delayed by years. Advancement in cross-sectional imaging techniques and advent of radionuclide-labeled somatostatin analogs have improved our accuracy of diagnosis and staging GEP NETs. Endoscopic ultrasound (EUS) wi

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Harrison, Olivia, Jianfa Bai, Martee Larson, et al. "PSI-4 Evaluation of chemical mitigants when soybean meal was inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory virus, and Seneca Valley virus 1." Journal of Animal Science 102, Supplement_2 (2024): 349–50. http://dx.doi.org/10.1093/jas/skae102.400.

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Abstract Chemical mitigants have been found to decrease virus concentrations in feed and ingredient matrices. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in these matrices. Therefore, the objective was to evaluate different inclusion levels of two different chemical mitigants when applied either before or after inoculation of porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV) and Seneca Valley virus 1 (SVV1) to soybean meal. The experiment was designed in a 2×2×2 factorial

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Seid, Abubeker Alebachew, and Abdulkerim Hassen Moloro. "Effectiveness of Neurodynamic Interventions in Patients With Stroke: Protocol for a Systematic Review and Meta-analysis." JMIR Research Protocols 11, no. 9 (2022): e38956. http://dx.doi.org/10.2196/38956.

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Background Stroke is the most common and serious neurological condition, which can lead to death, limited functionality, and reduced quality of life. Studies with conflicting results and various methodological limitations have been conducted to assess the effectiveness of neurodynamic interventions for patients with stroke. Objective This systematic review and meta-analysis aimed to investigate the pooled effectiveness of different neurodynamic interventions on patients with stroke. Methods The PubMed, PEDro, and Google Scholar databases will be searched for studies published with full text in

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Hardiansyah, Deni, Wei Guo, Ali Asgar Attarwala, Peter Kletting, Felix M. Mottaghy, and Gerhard Glatting. "Treatment planning in PRRT based on simulated PET data and a PBPK model." Nuklearmedizin 56, no. 01 (2017): 23–30. http://dx.doi.org/10.3413/nukmed-0819-16-04.

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SummaryAim: To investigate the accuracy of treatment planning in peptide-receptor radionuclide therapy (PRRT) based on simulated PET data (using a PET noise model) and a physiologically based pharmacokinetic (PBPK) model. Methods: The parameters of a PBPK model were fitted to the biokinetic data of 15 patients. True mathematical phantoms of patients (MPPs) were the PBPK model with the fitted parameters. PET measurements after bolus injection of 150 MBq 68Ga-DOTATATE were simulated for the true MPPs. PET noise with typical noise levels was added to the data (i.e. c=0.3 [low], 3, 30 and 300 [hig

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Boughen, Keaton, Tyler Neil, Shayan Dullemond, et al. "Cranial Nerve Noninvasive Neuromodulation in Adults With Neurological Conditions: Protocol for a Scoping Review." JMIR Research Protocols 10, no. 7 (2021): e29965. http://dx.doi.org/10.2196/29965.

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Background Cranial nerve noninvasive neuromodulation (CN-NINM) via translingual nerve stimulation (TLNS) is a promising new intervention combined with neurological rehabilitation to improve outcomes for persons with neurological conditions. A portable neuromodulation stimulation (PoNS) device rests on the tongue and stimulates cranial nerves V and VII (trigeminal and facial nerves, respectively). Emerging evidence suggests that CN-NINM using the PoNS device, combined with targeted physical therapy, improves balance and gait outcomes but has not yet been comprehensively reviewed. Objective This

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Krummenacher, Claude, Ann H. Rux, J. Charles Whitbeck, et al. "The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC." Journal of Virology 73, no. 10 (1999): 8127–37. http://dx.doi.org/10.1128/jvi.73.10.8127-8137.1999.

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The human herpesvirus entry mediator C (HveC/PRR1) is a member of the immunoglobulin family used as a cellular receptor by the alphaherpesviruses herpes simplex virus (HSV), pseudorabies virus, and bovine herpesvirus type 1. We previously demonstrated direct binding of the purified HveC ectodomain to purified HSV type 1 (HSV-1) and HSV-2 glycoprotein D (gD). Here, using a baculovirus expression system, we constructed and purified truncated forms of the receptor containing one [HveC(143t)], two [HveC(245t)], or all three immunoglobulin-like domains [HveC(346t)] of the extracellular region. All

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Moscarda, Viola, Elena Trevisani, Anna Reni, et al. "Precision medicine applied to rare malignancies: A single-center experience at University Hospital of Verona." Journal of Clinical Oncology 41, no. 16_suppl (2023): e16296-e16296. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16296.

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e16296 Background: Therapeutic resources are often limited in rare tumors. NGS (Next Generation Sequencing) represents a valuable tool that can provide biological and prognostic information and guide therapeutic options. Here we describe a case series of the University Hospital of Verona, a center of excellence for neuroendocrine and pancreatic neoplasms. Methods: Between October 2020 and December 2022, 75 patients (pts) with a neuroendocrine neoplasm (NEN) or mixed neuroendocrine non-neuroendocrine neoplasia (MiNEN) underwent NGS analysis with an in-house assay CORE panel (covering 174 genes;

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अर्जुन, सिंह छतोला. "महिला सशक्तिकरण और भारत". Journal of Research & Development' 14, № 7 (2022): 39–45. https://doi.org/10.5281/zenodo.6985076.

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<strong>izLrkouk</strong> & efgyk l'kfädj.k  dk rkRi;Z gS efgykvksa dks iq#"kks ads cjkcj  oSèkkfud] jktuhfrd] 'kkjhfjd] ekufld] lkekftd ,oa vkfFkZd {ks=ksa esa muds ifjokj] leqnk;] lekt ,oa jk"Vª dh lkaL—frd i`"BHkwfe esa fu.kZ; ysus dh Lo;rrk ls gksrkgSA21 oha lnh ds nwljs n'kd esa jktuhfr ds Lo:i esa cqfu;knh cnyko gq, gSa vkSj blus ,d ifjorZu'khy oSf”od ekgkSy cuk;k gSA Hkkjr  esa  lekurk  ds  fy,  efgykvksa  rFkk  fofHkUUk lewg vkxs c<s gSAjktuhfr esa efgykvksa dh oSf”od j

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अर्जुन, सिंह छतोला. "महिला सशक्तिकरण और भारत". Journal of Research & Development' 14, № 8 (2022): 39–45. https://doi.org/10.5281/zenodo.6988580.

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<strong>izLrkouk</strong> & efgyk l'kfädj.k  dk rkRi;Z gS efgykvksa dks iq#"kks ads cjkcj  oSèkkfud] jktuhfrd] 'kkjhfjd] ekufld] lkekftd ,oa vkfFkZd {ks=ksa esa muds ifjokj] leqnk;] lekt ,oa jk"Vª dh lkaL—frd i`"BHkwfe esa fu.kZ; ysus dh Lo;rrk ls gksrkgSA21 oha lnh ds nwljs n'kd esa jktuhfr ds Lo:i esa cqfu;knh cnyko gq, gSa vkSj blus ,d ifjorZu'khy oSf”od ekgkSy cuk;k gSA Hkkjr  esa  lekurk  ds  fy,  efgykvksa  rFkk  fofHkUUk lewg vkxs c<s gSAjktuhfr esa efgykvksa dh oSf”od j

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Beneforti, Linda, Erica Dander, Silvia Bresolin, et al. "Bone Marrow Mesenchymal Stromal Cells and Inflammation Contribute to ETV6-RUNX1+ Preleukemic Cells Persistence and DNA Damaging." Blood 132, Supplement 1 (2018): 3918. http://dx.doi.org/10.1182/blood-2018-99-114791.

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Abstract INTRODUCTION ETV6-RUNX1 (ER), generated from translocation t(12;21), is the most frequent fusion gene in pediatric cancers, exclusively leading to B-Cell Precursor Acute Lymphoblastic Leukemia. Translocation occurs in fetal hematopoietic stem-progenitor cells (HSPC) but it is insufficient for disease. ER, in fact, is an aberrant transcription factor that expands a silent preleukemic clone with enhanced self-renewal and partial B cell differentiation. Secondary hits are thus required to complete transformation. Epidemiological and experimental data indicate that infections/inflammation

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Suminski Jr, Richard Robert, Gregory Dominick, and Philip Saponaro. "Assessing Physical Activities Occurring on Sidewalks and Streets: Protocol for a Cross-Sectional Study." JMIR Research Protocols 8, no. 7 (2019): e12976. http://dx.doi.org/10.2196/12976.

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Background A considerable proportion of outdoor physical activity (PA) is done on sidewalks and streets, necessitating the development of a reliable measure of PA performed in these settings. The Block Walk Method (BWM) is one of the more common approaches for this purpose. Although it utilizes reliable observation techniques and displays criterion validity, it remains relatively unchanged since its introduction in 2006. It is a nontechnical, labor-intensive, first generation method. Advancing the BWM would contribute significantly to our understanding of PA behavior. Objective This study will

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Renson, Patricia, Sophie Mahé, Mathieu Andraud, et al. "Effect of vaccination route (intradermal vs. intramuscular) against porcine reproductive and respiratory syndrome using a modified live vaccine on systemic and mucosal immune response and virus transmission in pigs." BMC Veterinary Research 20, no. 1 (2024). http://dx.doi.org/10.1186/s12917-023-03853-4.

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Abstract Background Porcine reproductive and respiratory syndrome (PRRS) is a viral disease with worldwide distribution and an enormous economic impact. To control PRRS virus (PRRSV) infection, modified live vaccines (MLVs) are widely used in the field, mainly administered via an intramuscular (IM) route. Currently, some MLVs are authorized for intradermal (ID) administration, which has many practical and welfare advantages. The objectives of the study were to compare the immune responses (systemic in blood and mucosal in lungs) and vaccine efficacy in preventing challenge strain transmission

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Kreutzmann, Heinrich, Julia Stadler, Christian Knecht, et al. "Phenotypic Characterization of a Virulent PRRSV-1 Isolate in a Reproductive Model With and Without Prior Heterologous Modified Live PRRSV-1 Vaccination." Frontiers in Veterinary Science 9 (April 7, 2022). http://dx.doi.org/10.3389/fvets.2022.820233.

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Reproductive disorders induced by porcine reproductive and respiratory syndrome virus (PRRSV) cause high economic losses in the pig industry worldwide. In this study, we aimed to phenotypically characterize a virulent PRRSV-1 subtype 1 isolate (AUT15-33) in a reproductive model. Furthermore, the protective effect of a heterologous modified live virus vaccine (ReproCyc® PRRS EU) was evaluated. In addition, PRRSV AUT15-33 was genotypically compared to other well-characterized isolates. Sixteen gilts were equally divided into four groups: a vaccinated and infected group (V–I), a vaccinated and no

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Balestreri, Cecilia, Declan C. Schroeder, Fernando Sampedro, et al. "Unexpected thermal stability of two enveloped megaviruses, Emiliania huxleyi virus and African swine fever virus, as measured by viability PCR." Virology Journal 21, no. 1 (2024). http://dx.doi.org/10.1186/s12985-023-02272-z.

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Abstract Background The particle structure of Emiliania huxleyi virus (EhV), an algal infecting member of nucleocytoplasmic large DNA viruses (NCLDVs), contains an outer lipid membrane envelope similar to that found in animal viruses such as African swine fever virus (ASFV). Despite both being enveloped NCLDVs, EhV and ASFV are known for their stability outside their host environment. Method Here we report for the first time, the application of a viability qPCR (V-qPCR) method to describe the unprecedented and similar virion thermal stability of both EhV and ASFV. This result contradicts the c

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