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Artykuły w czasopismach na temat „PTX”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 11 marca 2023

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1

Ito, Ichiaki, Abdelrahman M. G. Yousef, Princess A. Dickson, Keith F. Fournier, Natalie Wall Fowlkes, and John Paul Y. C. Shen. "Antitumor activity of intraperitoneal (IP) paclitaxel to mucinous appendiceal adenocarcinoma in orthotopic patient-derived xenograft model." Journal of Clinical Oncology 41, no. 4_suppl (February 1, 2023): 151. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.151.

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151 Background: Appendiceal adenocarcinomas (AAs) are a rare and heterogeneous mix of tumors for which only few preclinical models exist for drug discovery. These tumors are commonly treated with chemotherapy like those for colorectal cancer despite clear evidence that the two cancers are distinctly different in their clinical behavior and molecular profiles. Taxanes such as paclitaxel (PTX) and docetaxel have been used in the systemic treatment of gastric cancer with peritoneal metastases. IP administration of PTX has been considered a promising treatment for eliminating peritoneal metastasis

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Kim, Gunzung, Imran Ashraf, Jeongsook Eom, and Yongwan Park. "Optimal Path Configuration with Coded Laser Pilots for Charging Electric Vehicles Using High Intensity Laser Power Beams." Applied Sciences 11, no. 9 (April 23, 2021): 3826. http://dx.doi.org/10.3390/app11093826.

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Wireless power transmission (WPT) for wireless charging has been gaining wide attention as a promising approach to miniaturizing the battery size and increasing the maximal total range of an electric vehicle (EV). With an appropriate charging infrastructure, WPT holds great potential to accelerate the acceptance of EVs through users’ higher satisfaction, reducing EV cost, and increasing the driving range and capability. A WPT system based on high-intensity laser power beaming (HILPB) provides an optimal solution for wirelessly charging electric vehicles from a distance of several meters. Despi

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Borghese, Cinzia, Naike Casagrande, Giuseppe Corona, and Donatella Aldinucci. "Adipose-Derived Stem Cells Primed with Paclitaxel Inhibit Ovarian Cancer Spheroid Growth and Overcome Paclitaxel Resistance." Pharmaceutics 12, no. 5 (April 27, 2020): 401. http://dx.doi.org/10.3390/pharmaceutics12050401.

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Adipose-derived stem cells (ADSCs) primed with paclitaxel (PTX) are now hypothesized to represent a potential Trojan horse to vehicle and deliver PTX into tumors. We analyzed the anticancer activity of PTX released by ADSCs primed with PTX (PTX-ADSCs) (~20 ng/mL) in a panel of ovarian cancer (OvCa) cells sensitive or resistant to PTX. We used two (2D) and three dimensional (3D) in vitro models (multicellular tumor spheroids, MCTSs, and heterospheroids) to mimic tumor growth in ascites. The coculture of OvCa cells with PTX-ADSCs inhibited cell viability in 2D models and in 3D heterospheroids (S

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4

Lippton, H. L., Q. Hao, T. Hauth, and A. Hyman. "Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 3 (March 1, 1992): H926—H929. http://dx.doi.org/10.1152/ajpheart.1992.262.3.h926.

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The purpose of the present study was to investigate the contribution of pertussis toxin (PTX)-sensitive guanine nucleotide (G) proteins in the pulmonary vascular response to adenosine and ATP in the intact cat under conditions of controlled pulmonary blood flow and left atrial pressure. Adenosine, ATP, and beta-tau-ATP increased lobar arterial pressure in a dose-dependent manner. The pulmonary vasoconstrictor response to adenosine was abolished by BW 1433U, a specific purinergic receptor (P1) inhibitor, PTX pretreatment, indomethacin, and ONO 3708, a thromboxane A2 (TxA2) receptor antagonist.

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Melloni, Elisabetta, Elena Marchesi, Lorenzo Preti, Fabio Casciano, Erika Rimondi, Arianna Romani, Paola Secchiero, Maria Luisa Navacchia, and Daniela Perrone. "Synthesis and Biological Investigation of Bile Acid-Paclitaxel Hybrids." Molecules 27, no. 2 (January 12, 2022): 471. http://dx.doi.org/10.3390/molecules27020471.

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Chenodeoxycholic acid and ursodeoxycholic acid (CDCA and UDCA, respectively) have been conjugated with paclitaxel (PTX) anticancer drugs through a high-yield condensation reaction. Bile acid-PTX hybrids (BA-PTX) have been investigated for their pro-apoptotic activity towards a selection of cancer cell lines as well as healthy fibroblast cells. Chenodeoxycholic-PTX hybrid (CDC-PTX) displayed cytotoxicity and cytoselectivity similar to PTX, whereas ursodeoxycholic-PTX hybrid (UDC-PTX) displayed some anticancer activity only towards HCT116 colon carcinoma cells. Pacific Blue (PB) conjugated deriv

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6

Koeda, Keisuke, Kohei Shitara, Atsuo Takashima, Kazumasa Fujitani, Hironori Tsujimoto, Akihito Tsuji, Eiji Oki, et al. "ABSOLUTE: A phase 3 trial of nanoparticle albumin-bound paclitaxel (nab-PTX) versus solvent-based paclitaxel (sb-PTX) in patients with pre-treated advanced gastric cancer (AGC)—Efficacy and QOL results." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 4010. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4010.

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4010 Background: Sb-PTX is a standard second-line treatment for patients (pts) with AGC. Nab-PTX was developed to avoid the toxicities with use of solvents in sb-PTX and potentially improve efficacy. Based on ABSOLUTE trial, we conducted the additional analysis to evaluate the efficacy and QOL of nab-PTX and sb-PTX. Methods: Pts who were refractory to a fluoropyrimidine-containing first-line treatment were randomly assigned (1:1:1) to receive intravenous q3w nab-PTX (260 mg/m2) on day 1 of a 21-day cycle, and q1w nab-PTX (100 mg/m2) or q1w sb-PTX (80 mg/m2) on days 1, 8, and 15 of a 28-day cyc

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7

Hyun, Hoon, Min Park, Gayoung Jo, So Kim, Heung Chun, and Dae Yang. "Photo-Cured Glycol Chitosan Hydrogel for Ovarian Cancer Drug Delivery." Marine Drugs 17, no. 1 (January 10, 2019): 41. http://dx.doi.org/10.3390/md17010041.

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In this study, we prepared an injectable drug delivery depot system based on a visible light-cured glycol chitosan (GC) hydrogel containing paclitaxel (PTX)-complexed beta-cyclodextrin (β-CD) (GC/CD/PTX) for ovarian cancer (OC) therapy using a tumor-bearing mouse model. The hydrogel depot system had a 23.8 Pa of storage modulus at 100 rad/s after visible light irradiation for 10 s. In addition, GC was swollen as a function of time. However, GC had no degradation with the time change. Eventually, the swollen GC matrix affected the releases of PTX and CD/PTX. GC/PTX and GC/CD/PTX exhibited a con

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8

Wang, Longkun, Chunqian Zhao, Lu Lu, Honglei Jiang, Fengshan Wang, and Xinke Zhang. "Transcytosable Peptide-Paclitaxel Prodrug Nanoparticle for Targeted Treatment of Triple-Negative Breast Cancer." International Journal of Molecular Sciences 24, no. 5 (February 28, 2023): 4646. http://dx.doi.org/10.3390/ijms24054646.

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Triple-negative breast cancer (TNBC) is an extremely aggressive subtype associated with a poor prognosis. At present, the treatment for TNBC mainly relies on surgery and traditional chemotherapy. As a key component in the standard treatment of TNBC, paclitaxel (PTX) effectively inhibits the growth and proliferation of tumor cells. However, the application of PTX in clinical treatment is limited due to its inherent hydrophobicity, weak penetrability, nonspecific accumulation, and side effects. To counter these problems, we constructed a novel PTX conjugate based on the peptide-drug conjugates (

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9

Mao, Yukang, Yili Zhang, Zheng Luo, Ruoting Zhan, Hui Xu, Weiwen Chen, and Huicai Huang. "Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs." Molecules 23, no. 12 (December 5, 2018): 3211. http://dx.doi.org/10.3390/molecules23123211.

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Paclitaxel (PTX) is a famous anti-cancer drug with poor aqueous solubility. In clinical practices, Cremophor EL (polyethoxylated castor oil), a toxic surfactant, is used for dissolution of PTX, which accounts for serious side effects. In the present study, a single glucose-conjugated PTX prodrug (SG-PTX) and a double glucose-conjugated PTX prodrug (DG-PTX) were synthesized with a glycosylated strategy via succinate linkers. Both of the two prodrugs presented significant solubility improvement and drug-like lipophilicities. Compared to DG-PTX, SG-PTX manifested more promising release of the par

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10

Tang, Bo, Yu Qian, Yi Gou, Gang Cheng, and Guihua Fang. "VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer." Molecules 23, no. 11 (October 25, 2018): 2760. http://dx.doi.org/10.3390/molecules23112760.

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Multi-drug resistance (MDR) presents a serious problem in cancer chemotherapy. In this study, Vitamin E (VE)-Albumin core-shell nanoparticles were developed for paclitaxel (PTX) delivery to improve the chemotherapy efficacy in an MDR breast cancer model. The PTX-loaded VE-Albumin core-shell nanoparticles (PTX-VE NPs) had small particle sizes (about 100 nm), high drug entrapment efficiency (95.7%) and loading capacity (12.5%), and showed sustained release profiles, in vitro. Docking studies indicated that the hydrophobic interaction and hydrogen bonds play a significant role in the formation of

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11

Wang, Ying, Ke-Chun Wu, Bing-Xiang Zhao, Xin Zhao, Xin Wang, Su Chen, Shu-Fang Nie, Wei-San Pan, Xuan Zhang, and Qiang Zhang. "A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, andIn VivoAntitumor Efficacy and Safety." Journal of Biomedicine and Biotechnology 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/854872.

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The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL. The pharmacokinetics, biodistribution,in vivoantitumor activity and safety of PTX microemulsion was evaluated. The results of pharmacokinetic and distribution properties of PTX in the microemulsion were similar to those of the PTX injection. The antitumor efficacy of the PTX microemulsion in OVCRA-3 and

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12

Nakasya, Akio, Yuya Hagiwara, Tatsuki Ikoma, Yusuke Kurioka, Toshihiko Matsumoto, Yoshiyuki Yamamoto, Takao Tsuduki, et al. "Nanoparticle albumin-bound paclitaxel and ramucirumab versus paclitaxel and ramucirumab as second-line chemotherapy for unresectable advanced or recurrent gastric cancer: a multicenter, propensity score-matched analysis (CROSS SELL study)." International Journal of Clinical Oncology 27, no. 4 (January 28, 2022): 684–94. http://dx.doi.org/10.1007/s10147-022-02114-y.

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Abstract Background Paclitaxel plus ramucirumab (PTX + RAM) is the standard second-line chemotherapy for unresectable advanced or recurrent gastric cancer (AGC). Nanoparticle albumin-bound paclitaxel (nab-PTX) is an improved, more convenient form of PTX and is non-inferior to PTX. Although some retrospective and single-arm phase II studies regarding nab-PTX + RAM have been reported, comparative studies are lacking. Here, we compared the efficacy and toxicity of nab-PTX + RAM and PTX + RAM using propensity score matching. Methods Clinical data of 265 patients treated for AGC with nab-PTX + RAM

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13

Yu, Na, Jun Li, Pankaj Kumar Singh, Dan Ding, Weihao Sun, Qiyun Tang, and Huae Xu. "The Superior Anticancer Effect of Reactive Oxygen Species-Responsive Paclitaxel Nanoparticles is Mediated Through Autophagic Cell Death." Journal of Biomedical Nanotechnology 15, no. 11 (November 1, 2019): 2251–61. http://dx.doi.org/10.1166/jbn.2019.2847.

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Paclitaxel (Ptx) is a first-line chemotherapeutic drug for advanced gastric cancer. However, the poor solubility of Ptx still limits its clinical application. Here, we designed a methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) (DSPE-PEG2000-TK-Ptx) nanoparticle loaded with "ROS sensitive" groups—thioketal (TK) to improve Ptx release in high ROS areas in cells. We evaluated the anticancer effect of the DSPE-PEG2000-TK-Ptx nanoparticles (Ptx-NPs) in the SGC-7901 gastric tumor cell line. The Ptx-NPs-treated group showed superior cytotoxicity to the same dose of free Ptx by MTT test and c

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14

Kimura, Michio, Eiseki Usami, Hitomi Teramachi, and Tomoaki Yoshimura. "Cost-effectiveness and safety of ramucirumab plus paclitaxel chemotherapy in the treatment of advanced and recurrent gastric cancer." Journal of Oncology Pharmacy Practice 24, no. 6 (April 24, 2017): 403–11. http://dx.doi.org/10.1177/1078155217707335.

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Introduction Weekly paclitaxel (PTX), irinotecan (CPT-11) and ramucirumab plus paclitaxel (Ram + PTX) are currently recommended as the standard second-line or later chemotherapies for advanced and recurrent gastric cancer. This study aims to compare the cost-effectiveness of using Ram + PTX vs. PTX or CPT-11. Furthermore, we investigated the safety and treatment continuity of Ram + PTX in Japan. Methods Expected costs were calculated based on data from patients with advanced and recurrent gastric cancer who were treated with PTX, CPT-11 and Ram + PTX. A literature review was performed to obtai

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15

Hirata, Kenro, Yasuo Hamamoto, Hirokazu Shoji, Hiroki Hara, Chihiro Kondoh, Hisateru Yasui, Takeshi Kajiwara, et al. "A randomized phase II trial of paclitaxel plus ramucirumab versus nab-paclitaxel plus ramucirumab for gastric cancer with peritoneal dissemination refractory to first-line therapy (WJOG10617G/P-SELECT)." Journal of Clinical Oncology 40, no. 4_suppl (February 1, 2022): 280. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.280.

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280 Background: Combination of ramucirumab (RAM) + weekly paclitaxel (PTX) is recommended as a standard second-line therapy for unresectable or recurrent gastric cancer (GC). A recent phase II trial evaluating nab-PTX and RAM combination showed that nab-PTX+RAM is promising efficacy and tolerability as well as PTX+RAM. In subgroup analysis of another phase III trial (ABSOLUTE) comparing different nab-PTX scheduling with PTX, weekly nab-PTX was especially effective for the patients with peritoneal dissemination compared to PTX without RAM combination. Therefore, we hypothesized that nab-PTX+RAM

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Zuo, Yangsong, Wenyi Shen, Lili Wang, Chengshi Wang, and Juan Pu. "Study on the Mechanism of Action of Paclitaxel-Loaded Polylactic-co-glycolic Acid Nanoparticles in Non-Small-Cell Lung Carcinoma Cells." Computational and Mathematical Methods in Medicine 2022 (April 6, 2022): 1–7. http://dx.doi.org/10.1155/2022/8524951.

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Objective. To study effective carriers that can enhance the antitumor effect of paclitaxel (PTX). Methods. PTX-loaded polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) (PTX-PLGA NPs), constructed using the emulsification solvent evaporation method, were characterized by scanning electron microscopy and dynamic light scattering. Non-small-cell lung carcinoma (NSCLC) cells were divided into the dimethyl sulfoxide (DMSO) group, PLGA NPs group, PTX group, and PTX-PLGA NPs group. Cell viability was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), cell apoptosis w

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Kitayama, Joji, Hironori Ishigami, Hironori Yamaguchi, Jun Yamada, Daisuke Soma, Hideyo Miyato, Takao Kamei, Alan Kawarai Lefor, and Naohiro Sata. "Optimal drug delivery for intraperitoneal paclitaxel (PTX) in murine model." Pleura and Peritoneum 2, no. 2 (June 27, 2017): 95–102. http://dx.doi.org/10.1515/pp-2017-0002.

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AbstractBackgroundRepeated intraperitoneal (IP) administration of paclitaxel (PTX) with concurrent systemic chemotherapy is clinically effective for the treatment of peritoneal metastases (PM) from gastric cancer. However, it is unclear how biochemical modifications may affect the pharmacokinetics and bioavailability of IP administered PTX.MethodsIn a xenograft PM model using human gastric cancer cells, MKN45, fluorescein-conjugated PTX (OG-PTX) was given IP and the intra-tumor distribution of PTX examined with fluorescein microscopy.ResultsAfter IP injection, PTX was seen to directly infiltra

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Hussain, Talib, Sathishbabu Paranthaman, Syed Mohd Danish Rizvi, Afrasim Moin, Devegowda Vishakante Gowda, Gehad Muhammed Subaiea, Mukhtar Ansari, and Abulrahman Sattam Alanazi. "Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management." Polymers 13, no. 19 (September 22, 2021): 3210. http://dx.doi.org/10.3390/polym13193210.

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Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and brain distribution study. PAX-RESV-loaded PNPs were prepared by the thin film hydration technique and optimized for different dependent and independent variables by using DoE (Design-Expert) software. The in vitro physiochemical characterization of prepared PAX-RESV-loaded PNP

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Chiu, Hui-Wen, Jeng-Shou Chang, Hui-Yu Lin, Hsun-Hua Lee, Chia-Hao Kuei, Che-Hsuan Lin, Huei-Mei Huang, and Yuan-Feng Lin. "FBXL7 Upregulation Predicts a Poor Prognosis and Associates with a Possible Mechanism for Paclitaxel Resistance in Ovarian Cancer." Journal of Clinical Medicine 7, no. 10 (October 6, 2018): 330. http://dx.doi.org/10.3390/jcm7100330.

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Paclitaxel (PTX) is a common regimen used to treat patients with ovarian cancer. Although approximately 60% of ovarian cancer patients exhibit a pathologic complete response (pCR), approximately 40% of patients appear to be insensitive to PTX adjuvant therapy. Thus, identifying a useful biomarker to predict pCR would be of great help to ovarian cancer patients who decide to receive PTX treatment. We found that FBXL7 was downregulated in OVSAHO (PTX-sensitive) but upregulated in KURAMOCHI (PTX-resistant) cells after PTX treatment at cytotoxic concentrations. Moreover, our data showed that the f

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Gomes, Fernando L. T., Raul C. Maranhão, Elaine R. Tavares, Priscila O. Carvalho, Maria L. Higuchi, Fernando R. Mattos, Fabio G. Pitta, Sergio A. Hatab, Roberto Kalil-Filho, and Carlos V. Serrano. "Regression of Atherosclerotic Plaques of Cholesterol-Fed Rabbits by Combined Chemotherapy With Paclitaxel and Methotrexate Carried in Lipid Core Nanoparticles." Journal of Cardiovascular Pharmacology and Therapeutics 23, no. 6 (May 20, 2018): 561–69. http://dx.doi.org/10.1177/1074248418778836.

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In previous studies, it was demonstrated that lipid core nanoparticles (LDE) resemble the low-density lipoprotein structure and carrying the antiproliferative agent paclitaxel (PTX) strongly reduced atherosclerosis lesions induced in rabbits by cholesterol feeding. Currently, the aim was to verify whether combining LDE-PTX treatment with methotrexate (MTX) associated with LDE (LDE-MTX) could accelerate the atherosclerosis regression attained with single LDE-PTX treatment, after withdrawing the cholesterol feeding. Thirty-eight rabbits were fed 1% cholesterol chow for 8 weeks. Six of these rabb

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Wilke, Hansjochen, Eric Van Cutsem, Sang Cheul Oh, Gyorgy Bodoky, Yasuhiro Shimada, Shuichi Hironaka, Naotoshi Sugimoto, et al. "RAINBOW: A global, phase III, randomized, double-blind study of ramucirumab plus paclitaxel versus placebo plus paclitaxel in the treatment of metastatic gastroesophageal junction (GEJ) and gastric adenocarcinoma following disease progression on first-line platinum- and fluoropyrimidine-containing combination therapy rainbow IMCL CP12-0922 (I4T-IE-JVBE)." Journal of Clinical Oncology 32, no. 3_suppl (January 20, 2014): LBA7. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.lba7.

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LBA7 Background: RAM is a human IgG1 monoclonal antibody VEGF-receptor 2 antagonist. We conducted a global, placebo-controlled, double-blind, phase III trial to evaluate the efficacy and safety of PTX +/- RAM in patients with metastatic GEJ or gastric adenocarcinoma who had disease progression on or within 4 months after first-line platinum- and fluoropyrimidine-based combination therapy. Methods: Pts received RAM (8 mg/kg IV q2w) or placebo (PL) plus PTX (80 mg/m2 d1, 8, 15 of a 4 week cycle) until disease progression, unacceptable toxicity, or death. Eligible pts had ECOG PS ≤ 1; and adequat

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Sontag, J. M., D. Thierse, B. Rouot, D. Aunis, and M. F. Bader. "A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers." Biochemical Journal 274, no. 2 (March 1, 1991): 339–47. http://dx.doi.org/10.1042/bj2740339.

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The role of GTP-binding proteins (G-proteins) in the secretory process in chromaffin cells was investigated by studying the effects of pertussis toxin (PTX) on catecholamine release and generation of various second messengers. PTX was found to stimulate the catecholamine secretion induced by nicotine, 59 mM-K+ or veratridine. PTX also potentiated Ca2(+)-evoked catecholamine release from permeabilized chromaffin cells, suggesting that PTX substrate(s) regulate the exocytotic machinery at a step distal to the rise in intracellular Ca2+. We have investigated the possible intracellular pathways in

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Li, Lingling, Saitian Zeng, Liang Guo, Ping Huang, Jie Xi, Jing Feng, Qian Li, et al. "Long Noncoding RNA RMRP Contributes to Paclitaxel Sensitivity of Ovarian Cancer by Regulating miR-580-3p/MICU1 Signaling." Journal of Oncology 2022 (January 29, 2022): 1–10. http://dx.doi.org/10.1155/2022/8301941.

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Ovarian cancer is a prevalent female malignancy affecting the health and life of an increasing population of women around the world. Paclitaxel (PTX) resistance is a significant clinical problem in the treatment of ovarian cancer. However, the regulation mechanism of PTX resistance remains unclear. In this investigation, we reported an innovative function of the long noncoding RNA RMRP in promoting PTX resistance and glycolysis of ovarian cancer cells. We observed that RMRP was highly expressed in the ovarian cancer samples, in which the expression of RMRP was elevated in the PTX-resistant pat

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Yonemaru, M., J. R. Hatherill, H. Hoffmann, H. Zheng, K. Ishii, and T. A. Raffin. "Pentoxifylline does not attenuate acute lung injury in the absence of granulocytes." Journal of Applied Physiology 71, no. 1 (July 1, 1991): 342–51. http://dx.doi.org/10.1152/jappl.1991.71.1.342.

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Pentoxifylline (PTX), a methylxanthine, can suppress polymorphonuclear leukocyte (PMN) activation and attenuate sepsis-induced acute lung injury. We investigated whether PTX prevents non-PMN-dependent lung injury. First we studied four groups of granulocyte-depleted guinea pigs (control, PTX, Escherichia coli, and E. coli + PTX). Lung injury was assessed by wet-to-dry lung weight (W/D) ratio and lung tissue-to-plasma 125I-albumin ratio (albumin index, AI). The E. coli group showed a significant increase in the lung W/D ratio and AI compared with the control and PTX groups. However, PTX did not

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Abu Samaan, Tala M., Marek Samec, Alena Liskova, Peter Kubatka, and Dietrich Büsselberg. "Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer." Biomolecules 9, no. 12 (November 27, 2019): 789. http://dx.doi.org/10.3390/biom9120789.

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Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of various types of malignant diseases. Mechanisms of PTX action represent several ways in which PTX affects cellular processes resulting in programmed cell death. PTX is frequently used as the first-line treatment drug in breast cancer (BC). Unfortunately, the resistance of BC to PTX treatment is a great obstacle in clinical applications and one of the major causes of death associated with treatment failure. Factors contributing to PTX resistance, such as ABC transporters, microRNAs (miRNAs), or mutations in

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Imai, Hiroo, Keigo Komine, Shin Takahashi, Ken Saijo, Yoshinari Okada, Akihiro Kobayashi, Akira Okita, et al. "Efficacy and Safety Assessment of Paclitaxel in Patients with Docetaxel-Resistant Esophageal Squamous Cell Carcinoma." Chemotherapy 61, no. 5 (2016): 262–68. http://dx.doi.org/10.1159/000444122.

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Background: Incomplete cross-resistances between paclitaxel (PTX) and docetaxel (DTX) has been demonstrated in several types of cancer. The objective of the present study was to assess the existence of cross-resistance between PTX and DTX in esophageal squamous cell carcinoma. Methods: Patients in the PTX group received PTX without DTX pretreatment, patients in the prior DTX (Pr-DTX) group received PTX after the development of resistance to DTX, and patients in the DTX group received DTX without subsequent PTX treatment. Results: A total of 73 patients were enrolled. The response rates to PTX

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Soe, Zar Chi, Wenquan Ou, Milan Gautam, Kishwor Poudel, Bo Kyun Kim, Le Minh Pham, Cao Dai Phung, et al. "Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel." Pharmaceutics 11, no. 11 (October 30, 2019): 562. http://dx.doi.org/10.3390/pharmaceutics11110562.

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In this study, we investigated the active targeted delivery of a hydrophobic drug, paclitaxel (PTX), via receptor-mediated endocytosis by folate receptors expressed on cancer cells using a protein-based nanoparticle system. PTX was loaded on zein nanoparticles and conjugated with folate (PTX/Zein-FA) to estimate its chemotherapeutic efficacy in folate receptor-expressing KB cancer cells. PTX/Zein-FA nanoparticles were successfully developed, with a nanoparticle size of ~180 nm and narrow polydispersity index (~0.22). Accelerated release of PTX in an acidic environment was observed for PTX/Zein

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Gao, Yu, Tao Liu, Xuan Liu, and Chao Wu. "Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines." Journal of Biomaterials Applications 34, no. 8 (December 26, 2019): 1071–80. http://dx.doi.org/10.1177/0885328219896457.

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Folic acid functionalized gelatin-coated mesoporous hollow carbon nanospheres (FGMCN) were synthesized and applied to enhance the antitumor curative effect of paclitaxel (PTX) for human liver cancer cell lines (SMMC-7721). PTX was loaded in FGMCN by the adsorption method and the PTX-loaded samples (PTX-FGMCN) had a drug content of 29.8 ± 1.06%. The PTX-FGMCN with a sustained release effect was characterized by X-ray diffraction and differential scanning calorimeter in order to analyze the PTX state in FGMCN. In vitro cell experiments showed that FMHSN improves the uptake of PTX and promotes ap

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Kuznetsov, Konstantin, Alena Stepanova, Ren Kvon, Timothy Douglas, Nikita Kuznetsov, Vera Chernonosova, Ivan Zaporozhchenko, et al. "Electrospun Produced 3D Matrices for Covering of Vascular Stents: Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment." Materials 11, no. 11 (November 2, 2018): 2176. http://dx.doi.org/10.3390/ma11112176.

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Paclitaxel is a natural, highly lipophilic anti proliferative drug widely used in medicine. We have studied the release of tritium-labeled paclitaxel (3H-PTX) from matrices destined for the coating of vascular stents and produced by the electrospinning method from the solutions of polycaprolactone (PCL) with paclitaxel (PTX) in hexafluoisopropanol (HFIP) and/or solutions of PCL with PTX and human serum albumin (HSA) in HFIP or HIFP-dimethyl sulphoxide (DMSO) blend. The release of PTX has been shown to depend on the composition of electrospinning solution, as well as the surrounding medium, par

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Zhong, Aimin, Viswanath Billa, Lorne E. Rotstein, Pui Y. Wong, Joanne M. Bargman, Stephen I. Vas, and Dimitrios G. Oreopoulos. "Recurrence of Hyperparathyroidism after Total Parathyroidectomy and Autotransplantation in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 20, no. 2 (March 2000): 200–208. http://dx.doi.org/10.1177/089686080002000207.

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Objective To evaluate the effectiveness of total parathyroidectomy (PTX) with autotransplantation in the treatment of secondary hyperparathyroidism (HPT), and to assess recurrence rate of HPT in this peritoneal dialysis (PD) population. Design A retrospective study in a single home PD unit. Patients Between 1994 and 1998, 19 of 574 patients on PD underwent PTX for treatment of secondary HPT. Main Outcome Measures Clinical and biochemical improvement, recurrence of HPT, improvement in anemia post-PTX. Results Nineteen (3.3%) patients required PTX between 1994 and 1998. These 5 men and 14 women

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Kimura, Yasue, Tetsuya Kusumoto, Eiji Kusumoto, Masahiko Sugiyama, Mitsuhiko Ohta, Norifumi Tsutsumi, Yoshihisa Sakaguchi, and Koji Ikejiri. "The comparison of the usefulness of nab-paclitaxel and paclitaxel for advanced or recurrent gastric cancer." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 217. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.217.

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217 Background: For patients who do not respond to S-1-based treatment in Japan, weekly paclitaxel (PTX) therapy is more frequently used as second-line chemotherapy. On the other hand, the agent could not be used for alcohol hypersensitivity in some cases. Nab-Paclitaxel (N-PTX), which is the protein-bound paclitaxel, has recently been introduced in Japan. The purpose of this study was to retrospectively determine the more preferable agent, N-PTX or PTX, following the S-1-containing chemotherapy in patients with advanced or recurrent gastric cancer (ARGC). Methods: We conducted a retrospective

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Zajdel, Alicja, Adam Wilczok, Katarzyna Jelonek, Monika Musiał-Kulik, Aleksander Foryś, Suming Li, and Janusz Kasperczyk. "Cytotoxic Effect of Paclitaxel and Lapatinib Co-Delivered in Polylactide-co-Poly(ethylene glycol) Micelles on HER-2-Negative Breast Cancer Cells." Pharmaceutics 11, no. 4 (April 6, 2019): 169. http://dx.doi.org/10.3390/pharmaceutics11040169.

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To find better strategies to enhance the cytotoxic effect of paclitaxel (PTX) and lapatinib (LAP) against breast cancer cells, we analyzed the efficacy of a novel delivery system containing polylactide-co-poly(ethylene glycol) (PLA-PEG) filomicelles of over 100 nm in length and spherical micelles of approximately 20 nm in diameter. The 1H NMR measurements confirmed the incorporation of PTX and LAP into micelles. Analysis of the drug release mechanism revealed the diffusion-controlled release of LAP and anomalous transport of PTX. Drug content analysis in lyophilized micelles and micellar solut

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Yang, Qilei, Chang Zu, Wengang Li, Weiwei Wu, Yunlong Ge, Lingling Wang, Li Wang, Yong Li, and Xiuhua Zhao. "Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent." Pharmaceutics 12, no. 11 (October 22, 2020): 1008. http://dx.doi.org/10.3390/pharmaceutics12111008.

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Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using 1-hexyl-3-methylimidazolium bromide (HMImBr) as solvent and water as an antisolvent. The factors influencing saturation solubility of PTX crystal powders in water in water were optimized using a single-factor design. The optimum conditions for the antisolvent precipitation process were as follows: 5

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34

Wei, Yuping, Liang Zhang, Yankai Fu, and Xia Xu. "Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth." Journal of Materials Chemistry B 5, no. 37 (2017): 7768–74. http://dx.doi.org/10.1039/c7tb01259d.

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PTX is rapidly translocated into HeLa cells with the help of R7. The intracellular PTX concentration of R7/PTX complex group is 3 fold that of the free PTX group. This delivery system does not contain any organic solvent. The tumor growth is significantly suppressed by a tail vein injection of the R7/PTX complex.

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Pan, Wang, Qian Wang, Yi Zhang, Naishu Zhang, Jiamin Qin, Wei Li, Jing Wang, Fangfang Wu, Lingsen Cao, and Guanglin Xu. "Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression." Cellular Physiology and Biochemistry 39, no. 2 (2016): 481–90. http://dx.doi.org/10.1159/000445640.

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Background/Aims: Paclitaxel (PTX) is one of the most effective anti-cancer drugs. However, multiple drug resistance is still the main factor that hinders the effective treatment of cancer with PTX. Several factors including YAP over-expression can cause PTX resistance. In this study, we aimed to verify the role YAP plays in PTX resistance, explore the reversal of PTX resistance by verteporfin (VP) and investigate the effect of combination therapy of PTX and VP on the PTX resistant colon cancer cells (HCT-8/T). Methods: To study the relationship between YAP and PTX resistance, a stable YAP-over

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Prinetti, Alessandro, Danilo Millimaggi, Sandra D'Ascenzo, Matilda Clarkson, Arianna Bettiga, Vanna Chigorno, Sandro Sonnino, Antonio Pavan, and Vincenza Dolo. "Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells." Biochemical Journal 395, no. 2 (March 28, 2006): 311–18. http://dx.doi.org/10.1042/bj20051184.

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PTX (Paclitaxel®) is an antimitotic agent used in the treatment of a number of major solid tumours, particularly in breast and ovarian cancer. This study was undertaken to gain insight into the molecular alterations producing PTX resistance in ovarian cancer. PTX treatment is able to induce apoptosis in the human ovarian carcinoma cell line, CABA I. PTX-induced apoptosis in CABA I cells was accompanied by an increase in the cellular Cer (ceramide) levels and a decrease in the sphingomyelin levels, due to the activation of sphingomyelinases. The inhibition of acid sphingomyelinase decreased PTX

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Nakatani, Yuki, Aya Nakaya, Takayasu Kurata, Takashi Yokoi, Yuki Takeyasu, Maiko Niki, Kayoko Kibata, et al. "Interstitial Lung Disease Following Single-Agent Nanoparticle Albumin-Bound Paclitaxel Treatment in Patients with Advanced Non-Small Cell Lung Cancer." Case Reports in Oncology 10, no. 2 (August 4, 2017): 683–88. http://dx.doi.org/10.1159/000479148.

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Interstitial lung disease (ILD) is a serious and potentially fatal adverse event in lung cancer therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a novel, solvent-free formulation of paclitaxel (PTX). Although the incidence of nab-PTX-induced ILD is not clear, it is generally considered that this formulation presents a similar risk of developing ILD as PTX. Here, we report 3 patients who developed severe ILD following treatment with nab-PTX. We draw attention to the risk of developing drug-induced ILD following nab-PTX treatment, and highlight that this novel formulation might theref

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Cui, Hongmei, Kinsie Arnst, Duane D. Miller, and Wei Li. "Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance." Current Medicinal Chemistry 27, no. 39 (November 24, 2020): 6573–95. http://dx.doi.org/10.2174/0929867326666191016113631.

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Paclitaxel (PTX) is a first-line drug for late-stage non-small cell lung cancer (NSCLC) patients who do not benefit from targeted therapy or immunotherapy. However, patients invariably develop resistance to PTX upon prolonged treatments. Although diverse mechanisms leading to PTX resistance have been well-documented in the literature, strategies to overcome PTX resistance in NSCLC based on these mechanisms are still challenging. In this article, we reviewed recent advancements elucidating major mechanisms of PTX resistance in NSCLC, including the overexpression of ABC transporters, alternation

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Nguyen, Thi Lan, Thi Hiep Nguyen, and Dai Hai Nguyen. "Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel." International Journal of Biomaterials 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/8234712.

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The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131±30.5 nm. Besides, PTX was efficiently encapsulated in Lips, 94.5±3.2% for drug loading efficiency, and slowly relea

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40

Ribeiro, Edson A., Luiz F. Poli-de-Figueiredo, Rodrigo Vincenzi, Flavio H. F. Galvao, Nelson Margarido, Mauricio Rocha-e-Silva, and Ruy J. Cruz. "Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury." HPB Surgery 2013 (August 29, 2013): 1–6. http://dx.doi.org/10.1155/2013/689835.

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Pentoxifylline (PTX) has been shown to have beneficial effects on microcirculatory blood flow. In this study we evaluate the potential hemodynamic and metabolic benefits of PTX during hepatic ischemia. We also test the hypothesis that portal PTX infusion can minimize the I/R injury when compared to systemic infusion. Methods. Twenty-four dogs ( kg) were subjected to portal triad occlusion (PTO) for 45 min. The animals were assigned to 3 groups: CT (control, PTO, ), PTX-syst (PTO + 25 mg/Kg of PTX IV, ), and PTX-pv (PTO + 25 mg/Kg of PTX in the portal vein, ). Animals were followed for 120 min.

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Kigawa, J., W. Kawaguchi, H. Itamochi, Y. Kanamori, T. Oishi, M. Shimada, S. Sato, S. Sato, and N. Terakawa. "Effect of simultaneous inhibition of MEK and PI3K/Akt pathways on paclitaxel sensitivity in ovarian cancer." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 16046. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.16046.

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16046 Background: Paclitaxel (PTX) is one of the key drugs for ovarian cancer treatment. PTX activates the Raf-mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol 3’-kinase (PI3K) pathways that lead to cell survival pathways. The purpose of this study was to clarify whether and how the inhibitors of MEK and/or PI3K affect the sensitivity to PTX in ovarian cancer cells. Methods: We treated five ovarian cancer cell lines in combination with PTX and MEK- [PD98059 (PD)] and/or PI3K-inhibitor [LY294002 (LY)] and assessed cell viability, apoptosis, and the expression of phosphoryl

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42

Cheng, Xingzhen, Fang Yang, Yang Wang, Wei Nie, Adarsha Mahendra Upadhyay, Maolin Zhang, Qian Wang, and Zhiqiang Yan. "Albumin Paclitaxel Compared with 5-Penfluorouracil, Lobaplatin, and Albumin Paclitaxel Combined with 5-Penfluorouracil in the Treatment of Human Gastric Cancer Cell AGS Line Autophagy and Apoptosis." Canadian Journal of Gastroenterology and Hepatology 2022 (June 10, 2022): 1–14. http://dx.doi.org/10.1155/2022/6015877.

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Background. Gastric cancer is one of the most common malignant tumors in the world. Albumin paclitaxel (Nab-PTX) is a novel microtubule inhibitor with albumin as the carrier. Several clinical trials are underway in gastric cancer, but the autophagy mechanism of Nab-PTX on gastric cancer is still unclear. The autophagy and apoptosis effects of Nab-PTX compared with 5-pentafluorouracil (5-Fu) and lobaplatin (LBP) in gastric cancer are also unclear. Objective. This article will compare the effects of Nab-PTX, 5-Fu, LBP, and albumin paclitaxel + 5-pentafluorouracil (Nab-PTX + 5-Fu) on AGS cells fr

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43

Zharikov, Sergey I., Karina Y. Krotova, Leonid Belayev та Edward R. Block. "Pertussis toxin activates l-arginine uptake in pulmonary endothelial cells through downregulation of PKC-α activity". American Journal of Physiology-Lung Cellular and Molecular Physiology 286, № 5 (травень 2004): L974—L983. http://dx.doi.org/10.1152/ajplung.00236.2003.

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Pertussis toxin (PTX) induces activation of l-arginine transport in pulmonary artery endothelial cells (PAEC). The effects of PTX on l-arginine transport appeared after 6 h of treatment and reached maximal values after treatment for 12 h. PTX-induced changes in l-arginine transport were not accompanied by changes in expression of cationic amino acid transporter (CAT)-1 protein, the main l-arginine transporter in PAEC. Unlike holotoxin, the β-oligomer-binding subunit of PTX did not affect l-arginine transport in PAEC, suggesting that Gαi ribosylation is an important step in the activation of l-

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44

Monroe, J. J., and A. H. Tashjian. "Palytoxin modulates cytosolic pH in human osteoblast-like Saos-2 cells via an interaction with Na(+)-K(+)-ATPase." American Journal of Physiology-Cell Physiology 270, no. 5 (May 1, 1996): C1277—C1283. http://dx.doi.org/10.1152/ajpcell.1996.270.5.c1277.

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Palytoxin (PTx) at nanomolar concentrations enhances the permeability of mammalian cell membranes to both Na+ and Ca2+. In basal human osteoblast-like Saos-2 cells, PTx (8 nM) caused a persistent decrease in cytosolic pH (pHi) of about 0.2 units, which required the presence of extracellular Ca2+ (Cae2+) and Na+ (Nae+). We acidified Saos-2 cells by incubation with nigericin to examine the action of PTx in cells with an activated Na+/H+ antiporter. Under these conditions, PTx increased the pHi without requiring Cae2+ or Nae+, and the alkalinization was unaffected by hexamethylene amiloride. We c

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Markeb, Ahmed A., Nagwa A. El-Maali, Douaa M. Sayed, Amany Osama, Mohamed A. Y. Abdel-Malek, Amen H. Zaki, Mostafa E. A. Elwanis, and James J. Driscoll. "Synthesis, Structural Characterization, and Preclinical Efficacy of a Novel Paclitaxel-Loaded Alginate Nanoparticle for Breast Cancer Treatment." International Journal of Breast Cancer 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/7549372.

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Purpose. The antitumor activity of a novel alginate (ALG) polymer-based particle that contained paclitaxel (PTX) was evaluated using human primary breast cancer cells.Materials and Methods. PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-linking methods that improved the aqueous solubility. Structural and biophysical properties of the PTX-ALG nanoparticles were then determined by transmission electron microscopy (TEM) and high performance

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46

Xu, Xiaoyan, Chao Wu, Andi Bai, Xuan Liu, Huiling Lv, and Ying Liu. "Folate-Functionalized Mesoporous Silica Nanoparticles as a Liver Tumor-Targeted Drug Delivery System to Improve the Antitumor Effect of Paclitaxel." Journal of Nanomaterials 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/2069685.

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The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution investigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid f

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47

Yang, Haotian, Jun Zhang, Ying Huan, Yawei Xu, and Rong Guo. "Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism." Disease Markers 2019 (March 12, 2019): 1–6. http://dx.doi.org/10.1155/2019/2324515.

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Objective. To investigate the value of the PTX-3 test in evaluating the prognosis of acute pulmonary embolism (APE). Method. 117 APE patients were selected and divided into two groups according to plasma PTX-3 levels, including the group in which PTX−3≥3.0 ng/mL (n=42) and the group in which PTX−3<3.0 ng/mL (n=75). Patients were stratified into high-risk, medium-risk, and low-risk groups according to the Wells scores, and the PTX-3 levels were compared among the groups. Patients had been followed-up as well. Results. According to the Wells scores, 11 patients were classified as high-risk (9

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Sun, Hongwen, Xiaoting Zhou, Yanan Bao, Guosheng Xiong, Yue Cui, and Hua Zhou. "Involvement of miR-4262 in paclitaxel resistance through the regulation of PTEN in non-small cell lung cancer." Open Biology 9, no. 7 (July 2019): 180227. http://dx.doi.org/10.1098/rsob.180227.

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Non-small cell lung cancer (NSCLC) is considered to be the primary cause of cancer-related mortalities worldwide. Paclitaxel (PTX), either as a monotherapy or in combination with other drugs, is an alternative therapy for advanced NSCLC. However, cancer cell resistance against PTX represents a major clinical problem. This study aimed to investigate the role and underlying mechanism of miR-4262 in PTX-resistant NSCLC. The levels of miR-4262 were analysed by quantitative reverse transcription polymerase chain reaction. A luciferase reporter assay and bioinformatics were used to explore the poten

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Liao, Shang-Chih, Sin-Hua Moi, Fong-Fu Chou, Cheng-Hong Yang, and Jin-Bor Chen. "Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6453803.

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Background. We examined the changes in circulating fibroblast growth factor 23 (FGF23) and Klotho concentrations in hemodialysis patients after parathyroidectomy (PTX). Methods. We enrolled a cohort of hemodialysis patients who received PTX. Postoperatively, patients received calcium supplements and/or vitamin D analogue (calcitriol) to maintain serum calcium within 7.0–8.0 mg/dL. Information on clinical parameters including bone-mineral metabolic variables was collected pre-PTX and on days 5 and 90 after PTX. Concomitantly, serum full-length FGF23 and α-Klotho levels were measured. The relati

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Airoldi, M., L. Cattel, R. Passera, P. Milla, L. Delprino, C. Boselli, C. Buffa, and F. Pedani. "Paclitaxel and pegylated liposomal doxorubicin in recurrent head/neck cancer: An unexpected administration interval-dependent pharmacokinetic interaction." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 2042. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.2042.

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2042 Background: Combination of paclitaxel (PTX) with pegylated liposomal doxorubicin (PLD) is an interesting opportunity for recurrent head/neck cancer treatment. Their pharmacokinetic (PK) behavior could be dependent not only on PTX excipient (polyethoxylated castor oil) interference, but also on different iv administration interval between the two drugs. The study endpoint was to evaluate any possible administration interval-dependent PK interaction, when PLD infusion start is delayed from 0 to 24 h after PTX infusion end. Methods: 24 patients affected by recurrent cisplatin pre-treated squ

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