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Artykuły w czasopismach na temat „Pulsatile drug delivery system”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Sharma, Abhimanyu Rai, Binu Raina, Prabhjot Singh Bajwa, Anurag Bhargava, Toshiba Toshiba, and Vrinda Goel. "Pulsatile Drug Delivery System-A Review." Asian Pacific Journal of Health Sciences 5, no. 3 (2018): 260–70. http://dx.doi.org/10.21276/apjhs.2018.5.3.38.

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Kundan Rajendra Mahajan, Ashish Prakash Gorle, and Vijay Sanjay Khalane. "Overview on pulsatile drug delivery system." International Journal of Science and Research Archive 5, no. 2 (2022): 110–18. http://dx.doi.org/10.30574/ijsra.2022.5.2.0067.

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Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal

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Belgamwar, VeenaS, MadhuriV Gaikwad, GaneshB Patil, and Sanjay Surana. "Pulsatile drug delivery system." Asian Journal of Pharmaceutics 2, no. 3 (2008): 141. http://dx.doi.org/10.4103/0973-8398.43297.

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SHARMA, PRASHANT. "Pulsatile Drug Delivery System – A Novel Approach for Time and Spatial Controlled Drug Delivery." Journal of Pharmaceutical Technology, Research and Management 4, no. 1 (2016): 13–29. http://dx.doi.org/10.15415/jptrm.2016.41002.

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Kapila, Arpita* Rambabu Sharma Agarwal Shweta. "PULSATILE DRUG DELIVERY SYSTEM: A MECHANISTIC UPDATE." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 3928–34. https://doi.org/10.5281/zenodo.1042593.

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Pulsatile drug delivery systems are the systems which deliver the drug according to the circadian rhythm of the body. The product follows a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus, these systems deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Various capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible polymer coatings, rupturable membran

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Garg, Tarun. "PULSATILE DRUG DELIVERY SYSTEMS: PULSINCAP SYSTEM." IOSR Journal of Pharmacy (IOSRPHR) 2, no. 2 (2012): 338–39. http://dx.doi.org/10.9790/3013-0220338339.

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Shelke Amruta P, Wagh Priti A, Nikam Sakshi M, and Bhosale Jaydeep J. "Pulsatile drug delivery system: A review." World Journal of Biology Pharmacy and Health Sciences 21, no. 2 (2025): 457–66. https://doi.org/10.30574/wjbphs.2025.21.2.0187.

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Pulsatile Drug Delivery Systems (PDDS) are increasingly recognized for their ability to deliver drugs at specific times, tailored to the pathophysiological needs of a disease. This approach enhances therapeutic efficacy and patient compliance. The core concept of PDDS involves a defined lag-time before a rapid drug release, which can be particularly beneficial for treatments requiring synchronization with the body’s natural circadian rhythms. By aligning peak plasma concentrations with these biological cycles, PDDS can improve both the safety and effectiveness of drugs over a 24-hour period. T

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Albadri, Ahmed A., Mustafa R. Abdulbaqi, and Yasir Q. Almajidi. "Recent Trends in Chronopharmaceutics, Pulsatile Drug Delivery System." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 4 (2019): 41–49. http://dx.doi.org/10.32947/ajps.v19i4.631.

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Pulsatile Drug Delivery Systems (PDDS) are getting considerable interest in delivering a drug at the correct position, at the correct time, and in the correct quantity, thus offering temporal, spatial, and intelligent delivery with improving patient compliance. These systems are  intended to meet body's biological rhythm. Here, the delivery of drugs is assisted by the rhythm of disease. The main reason for the using pulsatile drug release is when the continuous drug release is not required. A PDDS must be designed in such a way that after the lag time a complete and fast release of

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D., K. Singh, Poddar A.S., Nigade S.U., and S. Poddar S. "Pulsatile Drug Delivery System: An Overview." International Journal of Current Pharmaceutical Review and Research 2, no. 2 (2011): 55–80. https://doi.org/10.5281/zenodo.12698485.

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Pulsatile drug delivery systems (PDDS) are gaining importance as they deliver a drug atspecific time as per the pathophysiological need of the disease, resulting in improvedtherapeutic efficacy as well as compliance. Diseases wherein PDDS are promising includeasthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children,and hypercholesterolemia. These delivery systems can be classified into time controlledwherein the drug release is governed primarily by the delivery system; stimuli induced inwhich release is controlled by a stimuli, like the pH or enzymes pr

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Hussein, Mayssam, and Israa Nathir. "Pulsatile Drug Delivery System Utilizing Innovative Technology." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 601–6. http://dx.doi.org/10.53350/pjmhs22166601.

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Drugs might be released immediately or over time. Pulsatile medication release systems, on the other hand, have been increasing in popularity in recent years. Many medications or therapies could benefit from pulsatile drug release, in which the drug is released rapidly after a predetermined lag time. Pulsatile release systems come in pairs: multi and separate pulse. Rupturable dose forms are a prominent type of single-pulse device. Other methods have a drug-containing centre covered by both a swelling surface and a semi - permeable barrier polymer layer or membrane that is semipermeable but no

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Solunke, Dr Rahul S. "Pulsatile Drug Delivery System: A Review." International Journal for Research in Applied Science and Engineering Technology 11, no. 12 (2023): 409–16. http://dx.doi.org/10.22214/ijraset.2023.57351.

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Abstract: The pulsatile drug delivery system has carried off a lot of importance in drug delivery technology in the last 30 years the aim of the present work was to formulate and evaluate an oral pulsatile drug delivery system to achieve time release of melonixcam, based on chronopharmaceutical approach for the treatment of anti-inflammatory agent. Thus drug can be delivered at righttime, in right amount and at right site of action by use of such approach. A pulse must be planned sothat a complete and rapid medication release is accomplished after the lag time. Holds good promises and provides

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N., Shiva Krishna* Dr. B. Jayanthi A. Madhukar. "A REVIEW OF PULSATILE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 05, no. 06 (2018): 5488–94. https://doi.org/10.5281/zenodo.1296981.

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<em>Pulsatile drug delivery systems are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site.the product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. diseases where in chronopharmaceutics are promising include asthma,peptic ulcers, cardiovascular diseases, arthritis, neurological disorders and hypercholesterolemia etc. various capsular, osmotic, single and multiple unit systems that are modulated by soluble (or) er

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Gangadhar, B., B. Sai Bhanu Sree, PV Swamy, and M. Aruna Devi. "PULSATILE DRUG DELIVERY SYSTEM: A REVIEW." International Journal of Research in Ayurveda and Pharmacy 13, no. 6 (2022): 124–30. http://dx.doi.org/10.7897/2277-4343.1306171.

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Pulsatile Drug Delivery Systems (PDDS) are gaining a lot of interest as the delivery of the drug will be at the right site and at the right time, and the amount of drug that is reaching the site of action will also be so accurate, and therefore it generally improves the patient compliance. These followed a sigmoidal drug release profile and were characterized by a time of no drug release followed by a rapid and complete drug release. This article focuses on the various types of methodologies involved for the existing system and different marketed technologies, including PulsincapTM, OROS, DIFF

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Liu, Xin-Ming, Bin Yang, Yu-Lu Wang, and Jin-Ye Wang. "New Nanoscale Pulsatile Drug Delivery System." Chemistry of Materials 17, no. 11 (2005): 2792–95. http://dx.doi.org/10.1021/cm0479335.

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Dhengale, Amit A., Avinash B. Darekar, and R. B. Saudagar. "A Review: Pulsatile Drug Delivery System." Research Journal of Pharmaceutical Dosage Forms and Technology 8, no. 3 (2016): 221. http://dx.doi.org/10.5958/0975-4377.2016.00031.8.

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Bussemer, Till, Ina Otto, and Roland Bodmeier. "Pulsatile Drug-Delivery Systems." Critical Reviews in Therapeutic Drug Carrier Systems 18, no. 5 (2001): 26. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v18.i5.10.

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Lalwani, Anita, and DD Santani. "Pulsatile drug delivery systems." Indian Journal of Pharmaceutical Sciences 69, no. 4 (2007): 489. http://dx.doi.org/10.4103/0250-474x.36932.

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Yadav, Rajni, Megha Jha, Diksha Jat, and Deepak Kumar Jain. "Present scenario of pulsatile drug delivery system." IP International Journal of Comprehensive and Advanced Pharmacology 7, no. 4 (2023): 171–78. http://dx.doi.org/10.18231/j.ijcaap.2022.035.

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In current years, pulsatile drug release systems (PDRS) are ahead raising attention as compared to conventional drugs. In this delivery system, the drug is liberate quickly after a well defined insulate-time, could be helpful for many medicines or treatments. It can be labeled in single and a couple of-pulse structures. Other structures consist of a drug-enclosed core, enclosed by means of a swelling layer and an outer layer is insoluble, however coating with semipermeable polymer. The lag time earlier to the rupture is specifically controlled via: the penetration and mechanical houses of the

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Vani, Chiluvuru, and K. Srinivas Reddy. "PULSATILE DRUG DELIVERY SYSTEM-A TECHNIQUE OF DELIVERING DRUG IN ACCORDANCE WITH BIOLOGICAL CLOCK - A REVIEW." International Journal of Advanced Research 9, no. 4 (2021): 101–24. http://dx.doi.org/10.21474/ijar01/12813.

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Over last 30 years pulsatile drug delivery system has achieved a lot of importance in drug delivery technology. And the reason why this pulsatile drug delivery is gaining importance is because of its strategy of delivering drug molecule at right place, right time. There are certain diseases which are controlled by biological clock of our body and follow circadian rhythms like congestive heart failure, asthma, rheumatoid arthritis ,osteoarthritis, inflammatory disorders and other hormonal disorders, for this type of diseases conventional solid dosage forms like immediate release tablets or modi

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Parmar, Ramesh D., Rajesh K. Parikh, G. Vidyasagar, Dhaval V. Patel, Chirag J. Patel, and Biraju D. Patel. "Pulsatile Drug Delivery Systems: An Overview." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 605–14. http://dx.doi.org/10.37285/ijpsn.2009.2.3.3.

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Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single- an

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Gouse, Firoz Syed, Kothai R., and Arul B. "Formulation and Evaluation of Colon Specific Pulsatile Drug Delivery System of Zidovudine." International Journal of Zoological Investigations 08, Special Issue (2022): 85–90. http://dx.doi.org/10.33745/ijzi.2022.v08i0s.010.

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Traditional dosage forms are vastly outclassed by PDDS (pulsatile drug delivery systems). It is more effective than regular doses since it is delivered at the proper time, location, and dose. After a lag period, the medication is delivered as a whole pulse. The release profile of these products is sigmoid. Chronopharmacological drugs and pharmaceuticals with a first-pass effect benefit from these systems. The early research of zidovudine as an anticancer therapy had mediocre results, thus it is presently utilised to treat HIV-infected individuals as a thymidine analogue. For the medicine Zidov

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Rahul, Mante* Dr. R. S. Radke Dr. Aijaz Sheikh Dr. K. R. Biyani. "Formulation And Evaluation of Pulsatile Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2369–79. https://doi.org/10.5281/zenodo.15417701.

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Pulsatile drug delivery systems (PDDS) are designed to release drugs in a transient manner, following a predetermined lag time, to synchronize with the body's circadian rhythms or specific biological events. This study aimed to develop and evaluate a press-coated pulsatile tablet of Telmisartan, a drug commonly used to treat hypertension, where blood pressure typically peaks in the morning. Preformulation studies confirmed the drug's purity and solubility profile, with UV spectroscopy determining the maximum wavelength at 295 nm. Standard calibration curves were linear (2-18 µg/ml) in a

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Patil S. V., Salokhe P. A., Patil S. S., Ustad J. Y., and Shedbale S. S. "Formulation and Evaluation of Bio-adhesive Pulsatile Drug Delivery System of Telmisartan." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1282–87. http://dx.doi.org/10.26452/ijrps.v11i2.1982.

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The main objective of this study was to formulate and evaluate of Bio-adhesive pulsatile drug delivery system of Telmisartan, an anti-hypertensive drug in order to achieve better therapeutic efficacy and patient compliance. The approach of combination of bio-adhesive pulsatile formulation is suitable for gastro retention and time specific drug delivery. The study was carried by preparation of fast disintegrating core tablet followed by incorporation of core tablet to design bio-adhesive pulsatile tablet by press coating. The press coated tablet was prepared with the polymersethyl cellulose and

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Hameed, Huma, Arwa Khalid, Fazala Khalid, Rabeea Khan, and Akhtar Rasul. "Chrono pharmacotherapy: A pulsatile Drug Delivery." Pakistan Journal of Pharmaceutical Research 1, no. 1 (2015): 25. http://dx.doi.org/10.22200/pjpr.2015125-32.

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Chronopharmacotherapy refers to a treatment in which controlled drug delivery is achieved according to circadian rhythms of disease by enhancing therapeutic outcomes and minimizing side effects. Colon targeting has gained great importance not only for the treatment of local diseases such as Crohn’s disease, inflammatory bowel disease and ulcerative colitis but also very important in systemic delivery of proteins/peptides, antiasthmatic drugs, antidiabetic agents and antihypertensive drugs, which mostly show their efficacy based on circadian rhythms of the body.Colon drug delivery is one of the

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V, Ravali, and P. Balaji. "Pulsatile Drug Delivery Systems: A Comprehensive Review." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 463–71. http://dx.doi.org/10.25258/ijddt.14.1.65.

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sigmoidal drug release profile is formed when a pulsatile drug delivery system (PDDI) initiates drug administration and follows it up with rapid and complete drug release. It ensures the correct dosage of the drug is delivered at the right time and place. Pulsatile drug delivery is effective for treating asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcers, and hypercholesterolemia, among others. There are many types of delivery systems in the pharmaceutical industry, including capsular, osmotic, single and multi-unit designs and membranes that are soluble and erodible. Innovati

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Rao, N. G. Raghavendra, P. Soumya, K. Revathi, and B. Sanjeev Nayak. "A REVIEW ON PULSATILE DRUG DELIVERY SYSTEM." International Research Journal of Pharmacy 4, no. 3 (2013): 31–44. http://dx.doi.org/10.7897/2230-8407.04307.

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Khankari, Rupali V., and Sneha M. Umale. "A Review on Pulsatile Drug Delivery System." Asian Journal of Pharmacy and Technology 10, no. 2 (2020): 121. http://dx.doi.org/10.5958/2231-5713.2020.00021.5.

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Maroni, Alessandra, Lucia Zema, Matteo Cerea, and Maria Edvige Sangalli. "Oral pulsatile drug delivery systems." Expert Opinion on Drug Delivery 2, no. 5 (2005): 855–71. http://dx.doi.org/10.1517/17425247.2.5.855.

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james, Apollo, Jasmina khanam, Mohanraj Palanisamy, and Arun Radhakrishnan. "Preparation and Bio Pharmaceutical Evaluation of Chrono Pharmaceutical Drug Delivery System of Atenolol." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4761–69. http://dx.doi.org/10.55522/jmpas.v11i2.3310.

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A time-adjustable pulsatile release system containing atenolol as an active pharmaceutical agent was developed for bedtime dosage administration and release of medicine in the early morning to manage elevated blood pressure. The system contained an immediate release (IR) core, a sustained-release (SR) plug, and a mucoadhesive cup layer and it was designed by the cup and core technique. The immediate-release layer was composed of atenolol, croscarmellose sodium, microcrystalline cellulose (MCC), sorbitol, talc, and magnesium stearate. The SR plug was composed of hydroxyl propyl methylcellulose

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Agam, Tushar, Gangotri Yadav, Ashish Jain, Pallavi Ware, and Srushti Kamble. "Formulation and Evaluation of Pulsatile Drug Delivery System of Dexlansoprazole." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 5 (2023): 6976–78. http://dx.doi.org/10.37285/ijpsn.2023.16.5.6.

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Background: A pulsatile drug delivery system is intended to deliver drugs according to the circadian rhythm, or disease cycle. PDDS prepared by pulsincap technology contain a cross-linked hard gelatin capsule filled with the optimized immediate-release tablet, sodium alginate beads. Dexlansoprazole is used to treat the signs and symptoms of gastroesophageal reflux disease (GERD), erosive esophagitis, and stomach ulcers. Objective: The objective of the research is to develop and analyse a controlled-release pulsatile medication delivery system for the treatment of peptic ulcers that contains de

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Dhiraj S. Bhusewad, Sandip A. Wathore, Gunesh N. Dhembre, et al. "Development and evaluation of pulsatile drug delivery system of Telmisartan." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 403–12. http://dx.doi.org/10.30574/wjbphs.2024.20.2.0883.

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The aim of the present study was the formulation of pulsatile tablets of Telmisartan by press coating technique that could release the drug time controlled manner. The core tablets and press coated pulsatile tablet of Telmisartan was prepared by direct compression technique. The core tablets were formulated using super disintegrating agent cross carmilose sodium and pulsatile tablets were by using polymer HPMC and Ethyl cellulose in various concentrations. Compatibility studies indicate that there is no interaction between the excipient and the drug. All tablets formulations were subjected to

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Nath, Bipul, and Santimoni Saikia. "Characterization and Screening of a Novel Multiparticulate Pulsatile Delivery of Aceclofenac." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 5 (2016): 3494–501. http://dx.doi.org/10.37285/ijpsn.2016.9.5.7.

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In the present investigation, sodium alginate based multiparticulate system overcoated with time and pH dependent polymer was studied in the form of oral pulsatile system to achieve pulsatile with sustained release of aceclofenac for chronotherapy of rheumatoid arthritis seven batches of micro beads with varying concentration of sodium alginate (2-5 %) were prepared by ionotropic-gelation method using CaCl2 as cross-linking agent. The prepared Ca-alginate beads were coated with 5% Eudragit L100 and filled into pulsatile capsule with varying proportion of plugging materials. Drug loaded microbe

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SV, Patil, Sutar SB, Yesare SA, and Behera AL. "Innovations and Applications in Bioadhesive-Based Pulsatile Drug Delivery Systems." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 955–60. https://doi.org/10.25258/ijddt.14.4.69.

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Recent technological advancements have significantly increased the demand for Novel Drug Delivery Systems (NDDS) in the pharmaceutical industry. Controlled Drug Delivery Systems (CDDS) are a notable example, maintaining consistent drug levels and enhancing bioavailability. However, oral dosage forms can face challenges with fluctuating plasma levels and bioavailability due to variable gastric emptying rates, particularly affecting drugs absorbed in the upper gastrointestinal tract. To address this, Gastroretentive Formulations (GRDFs) have been created to extend gastric retention and improve d

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P, Mahalakshmi, Suriyaprakash T N K, and S. Lakshmana Prabu. "Chronomodulated Delivery of Pantoprazole for Nocturnal Hyperacidity." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3038–44. http://dx.doi.org/10.37285/ijpsn.2015.8.4.7.

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The objective of this work was to design and evaluate an oral site-specific, pulsatile drug delivery system containing Pantoprazole sodium which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal hyperacidity. Five different composition of Core tablets were prepared by direct compression technique. Based on the release studies of core tablets, nine different compositions of press coated tablets were prepared and analyzed. The press coated tablet further coated by using five different proportions of Eudragit

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Jagdale, Swati C., Sachin M. Chede, Ram Gulwady, et al. "Pulsatile multiparticulate drug delivery system for metoprolol succinate." Archives of Pharmacal Research 34, no. 3 (2011): 369–76. http://dx.doi.org/10.1007/s12272-011-0303-0.

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V., Rajesh Babu V. Mallikarjun Abdul Sayeed P. Rajasridhar Rao. "DESIGN AND EVALUATION OF MINI-TABLETS - PULSATILE DRUG DELIVERY SYSTEM OF RAMIPRIL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1839–49. https://doi.org/10.5281/zenodo.1211347.

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The aim of present study was to design and evaluate mini-tablets: pulsatile delivery of Ramipril based on chronophamaceutical approach for the treatment of hypertension. In the present study the immediate release core mini tablets were prepared by direct compression by using different superdisintegrantslike sodium starch glycollate, croscaramellose sodium and crospovidone. The optimized core tablets were then coated with PH sensitive polymers like Eudragit -S100 and Eudragit- L100. To get the desired dissolution profile various parameters like coating time and coat thickness studied. The formu

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Ali, J., Alka Ahuja, Sanjula Baboota, J. Qureshi, and Shweta Arora. "Pulsatile drug delivery systems: An approach for controlled drug delivery." Indian Journal of Pharmaceutical Sciences 68, no. 3 (2006): 295. http://dx.doi.org/10.4103/0250-474x.26655.

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Kolli, Dr Tirumala Devi, Dr Prasada Rao Manchineni, Dr Raghavendra Kumar Gunda, and Raja Mohan M. "DESIGN, DEVELOPMENT OF CARVEDILOL FLOATING PULSATILE DRUG DELIVERY SYSTEM." Journal of Applied Pharmaceutical Sciences and Research 7, no. 1 (2024): 41–45. http://dx.doi.org/10.31069/japsr.v7i1.07.

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Objective: The current study's objective is to develop and evaluate Floating Pulsatile delivery systems (FDT) for Carvedilol. Carvedilol, Non selective α, β- receptor blocking agent. It is indicated for the treatment of moderate heart failure, Hypertension. Methods: The rapid release core tablets were formulated using various concentrations of superdisintegrants such as croscaramellose sodium, crospovidone. The optimized pulsatile release tablets were prepared by using different grades of HPMC) at different concentrations Dry coated tablets were prepared by using combination of Pulsatile layer

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NAKAJIMA, Takehisa, and Kimiko MAKINO. "Pulsatile Drug Delivery Systems for Chronopharmacology." Oleoscience 1, no. 7 (2001): 765–72. http://dx.doi.org/10.5650/oleoscience.1.765.

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Yoshida, Ryo, Kiyotaka Sakai, Teruo Okano, and Yasuhisa Sakurai. "Pulsatile drug delivery systems using hydrogels." Advanced Drug Delivery Reviews 11, no. 1-2 (1993): 85–108. http://dx.doi.org/10.1016/0169-409x(93)90028-3.

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Kumar, Amit, Geeta Aggarwal, and S. L. HariKumar. "Colon Specific Drug Delivery by pH Sensitive Polymers & Pulsatile Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 05, no. 01 (2015): 06–11. http://dx.doi.org/10.35652/igjps.2015.18.

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Janugade, Bhagyesh U., and Neelam Singla. "Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 61–68. http://dx.doi.org/10.25258/ijpqa.15.1.09.

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The current research aimed to prepare and estimate bioadhesive pulsatile drug delivery system (BPDDS) of an antihypertensive drug, losartan potassium, containing the formulation of a fast-dissolving core tablet and a combination of core tablet to polymer coating to formulate (BPDDS) tablet through a direct compression procedure. The coating was completed by utilizing polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was entirely assessed for the formulations. Altogether, estimation tests were found to

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Bagade, Om M., Snehal S. Sutar, and Priyanka E. Doke. "A Concise Insight on Pulsatile Drug Delivery System: An Outlook towards its Development." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 5 (2021): 5577–87. http://dx.doi.org/10.37285/ijpsn.2021.14.5.1.

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In pharmaceutical science, the pulsatile drug delivery system gains more attraction because of their number of benefits over the other dosage forms. In these systems, the drug is released at right time at the right site of action, and in the right amount, it is the most beneficial and important characteristic of the PDDS system due to that the patient compliance is increased, and the drug release is after a well-defined lag time. Moreover, this system is designed according to the circadian rhythm of the body. Because the disease has a predictable cyclic rhythm, such as Arthritis, diabetes mell

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Saka Abisheknath, A. Venkateswara Rao, and M. Vineela. "Preparation and evaluation of press coated floating pulsatile drug delivery system of telmisartan." International Journal of Research in Pharmacology & Pharmacotherapeutics 12, no. 3 (2023): 166–74. http://dx.doi.org/10.61096/ijrpp.v12.iss3.2023.166-174.

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The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Telmisartan used for is a medication used for high blood pressure, heart failure, and diabetic kidney disease. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Telmisartan in the inner core were formulated by direct compression method with an outer coating of different amount of Chitosan. The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave goo

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Madhavi, Ala Vijaya, D. Rama Brahma Reddy, M. Venugopal, N. Srihari, P. Chenniah, and P. Koteswarao. "Formulation and Evaluation of Pulsatile Drug Delivery System of Zafirlukast." Journal of Drug Delivery and Therapeutics 10, no. 2 (2020): 122–28. http://dx.doi.org/10.22270/jddt.v10i2.3983.

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In the current scenario of pharmaceutical research much attention has been focused on patients health in terms of therapeutic efficacy and economical standards (price factor).The formulation design consist of core tablets designed by direct compression method. Core tablets were coated with an naturally occurring swelling agent (carbopol & Karaya gum). Evaluation studies were performed for prepared pulsatile tablets hardness. In in vitro release profile of 6 hours study in first 5 hours it shows minimum drug release and at the end of six hours rapid and transient release was observed. Stabi

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Bhaskar, Shrestha Sajan Maharjan* Himal Chhetry Panna Thapa. "Formulation and in vitro evaluation of floating pulsatile drug delivery system of Atenolol based on coated effervescent core." Int. J. in Pharm. Sci. 1, no. 8 (2023): 140–51. https://doi.org/10.5281/zenodo.8249869.

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Present research work attempts to design, formulate and optimize the floating pulsatile drug delivery system (FPPDS) intended to treat nocturnal hypertension. FPPDS was designed based on central reservoir system containing effervescent agent with rupturable coating and a buoyant layer on top of the coated core. This system consists of rapid release core that contains drug with disintegrants, osmogent (sodium chloride) and effervescent agent (sodium bicarbonate and tartaric acid) which was film coated by hydrophobic polymer Ethyl Cellulose(EC) with polyethylene Glycol(PEG) 6000 as a plasticizer

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Raj, Behin Sundara, I. S. R. Punitha, and M. J. Gifty. "Formulation and Evaluation of Floating Pulsatile Drug Delivery System of Ibuprofen and Ranitidine Combination." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3009–17. http://dx.doi.org/10.37285/ijpsn.2015.8.4.3.

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Since rheumatoid arthritis patients experience severe pain, inflammation, and joint stiffness in the early morning hours a pulsatile drug delivery system of a suitable anti-inflammatory drug that is administered at bedtime but release the drug in the early morning would be a promising system. The objective of this work was to develop a pulsatile release tablet containing a combination of ibuprofen and ranitidine HCl from which ibuprofen gets released after a lag time of 6-7 hours. The methodology involves; analytical method development for simultaneous estimation of combination drugs, developm

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Mohui, Yang, Wang Xingli, Ouyang Jiabi, Zhang Zhen, Tan Yani, and Li Sha. "Drug Release and Pharmacokinetics Behavior of a Simple Ethylcellulose Coating Pulsatile Tablet of Time-Controlled Explosive System." Journal of Pharmaceutical and Biomedical Sciences 10, no. 03 (2020): 57–64. https://doi.org/10.5281/zenodo.3903310.

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<em><strong>Core tip:</strong></em> The time rhythm of the human body is associated with the occurrence and development of many diseases. Kinds of diseases of particular onset biorhythm provided the room for the development of chronopharmacological drug delivery systems. Metoprolol tartrate (MT), a medicine commonly used for treatment of cardiovascular diseases in clinic, was selected as model drug to develop a time-controlled explosive pulsatile tablet. The prepared MT pulsatile tablets showed a drug release lag time of 7.10 h <em>in vitro</em> perfectly consistent with the absorption lag tim

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Das, Sudipta, Baishali Ghosh, and Surita Basu. "Formulation and Evaluation of Pulsatile Drug Delivery System of Atenolol." Journal of Basic and Applied Research in Biomedicine 6, no. 1 (2020): 45–49. http://dx.doi.org/10.51152/jbarbiomed.v6i1.8.

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The objective of the present study was formulation and evaluation of pulsatile release tablets of Atenolol. A tablet system consisting of cores which was coated with layers of swelling and rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression with appropriate ratios of lactose and microcrystalline cellulose and then coated sequentially with different ratios of an inner swelling layer containing HPMC and an outer rupturable layer of Ethyl Cellulose. The effect of level of swelling layer and rupturable coating was investigated. The different formulation

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KUMAR, YEDHUNOORI GANESH, Ravi Pratap Pulla, A. Ganesh, G. Naresh, and Afreen Saleem. "FORMULATION AND IN-VITRO EVALUATION OF FLOATING PULSATILE DRUG DELIVERY SYSTEM OF IVABRADINE." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 188–93. http://dx.doi.org/10.22270/jddt.v9i3.2862.

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The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Ivabradine used for is a medication used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Ivabradine in the inner core were formulated by direct compression method with an outer coating of different amount of HPMCK200 M. The release profile of press coated tablet ex

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