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Rozprawy doktorskie na temat „Quinolinic acid”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Allsebrook, Andrew M. "QPRTase : quinolinic acid analogue synthesis and non-enzymic decarboxylation of N-alkylquinolinic acids." Thesis, University of St Andrews, 1998. http://hdl.handle.net/10023/14376.

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Quinolinate phosphoribosyltransferase (QPRTase, E.C. 2.4.2.19) is considered to be a unique enzyme in that it is thought to catalyse two distinct chemical reactions. Both the transfer of a phosphoribosyl group from 5-phosphoribosyl-1- pyrophosphate onto the nitrogen of quinolinic acid and the subsequent decarboxylation of the intermediate to form nicotinic acid mononucleotide are thought to be catalysed by the QPRTase system. Analogues of quinolinic acid were designed as potential inhibitors of QPRTase. These contain acidic groups at the 2- and 3- positions but are unable to decarboxylate. How

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Miranda, Allan F. "Modulation of quinolinic acid-induced excitotoxicity by endogenous kynurenine pathway intermediates." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq22484.pdf.

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Urenjak, Jutta A., and Tihomir P. Obrenovitch. "Accumulation of quinolinic acid with euro-inflammation: does it mean excitotoxicity?" Thesis, Kluwer Academic, Plenum Publishers, New York, 2003. http://hdl.handle.net/10454/2833.

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Morgan, Elaine M. "The role of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243084.

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Catton, Gemma R. "Mechanistic studies on quinolinate phosphoribosyltransferase /." St Andrews, 2007. http://hdl.handle.net/10023/485.

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Kariyawasam, Sandhya Himani. "An investigation into the biochemical changes in Tourette syndrome and associated conditions with a potential for pharmacological manipulation." Thesis, Aston University, 1999. http://publications.aston.ac.uk/10977/.

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Kynurenine (KYN) is the first stable metabolite of the kynurenine pathway, which accounts for over 95% of tryptophan metabolism. Two previous studies by this research group reported elevated plasma KYN in Tourette syndrome (TS) patients when compared with age and sex matched controls and another study showed that KYN potentiated 5-HT2A-mediated head-shakes (HS) in rodents. These movements have been suggested to model tics in TS. This raised the questions how KYN acts in eliciting this response and whether it is an action of its own or of a further metabolite along the kynurenine pathway. In th

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Heron, Paula Michelle. "An investigation of the neuroprotective effects of estrogen in a model of quinolinic acid-induced neurodegeneration." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003237.

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The hippocampus, located in the medial temporal lobe, is an important region of the brain responsible for the formation of memory. Thus, any agent that induces stress in this area has detrimental effects and could lead to various types of dementia. Such agents include the neurotoxin, Quinolinic acid. Quinolinic acid (QUIN) is a neurotoxic metabolite of the tryptophan-kynurenine pathway and is an endogenous glutamate agonist that selectively injures and kills vulnerable neurons via the activation of the NMDA class of excitatory amino acid receptors. Estrogen is a female hormone that is responsi

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8

Thian, Stefanie. "The quinolinic acid lesion of the neostriatum examined in the context of neuronal transplantation." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624769.

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Ting, Ka Ka Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Quinolinic acid and its effect on the astrocyte with relevance to the pathogenesis of Alzheimer??s disease." Publisher:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/41288.

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There is evidence that the excitotoxin quinolinic acid (QUIN) synthesized through the kynurenine pathway (KP) by activated microglia may play a role in the pathogenesis of several major neuroinflammatory diseases and more particularly in Alzheimer??s disease (AD). The hypothesis of this project is QUIN affects the function and morphology of astrocytes. In this study I used human foetal astrocytes stimulated with AD associated cytokines including IFN-gamma, TNF-alpha, TGF-alpha and different concentrations of QUIN ranging from low physiological to high excitotoxic concentrations. I found that Q

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10

Chen, Yiquan Medical Sciences Faculty of Medicine UNSW. "The involvement of the Kynurenine pathway in amyotrophic lateral sclerosis." Publisher:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/43774.

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Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease of unclear aetiology, although the general consensus is of a multifactorial disease. The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS. The KP is the major route for tryptophan (TRP) catabolism. The intermediates generated can be either neurotoxic, such as quinolinic acid (QUIN), or neuroprotective, such as picolinic acid (PIC), an important endogenous metal chelator. The first and inducible enzyme is indoleamine 2,3-dioxygenase (IDO). As the e

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11

Lee, Christopher James. "Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0020/MQ48164.pdf.

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12

Yan, Edwin B., Tony Frugier, Chai K. Lim, et al. "Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans." BioMed Central, 2015. http://hdl.handle.net/10150/610324.

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ABSTRACT: During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydroxykynurenine (3HK). Despite the importance of excitotoxicity in the development of secondary brain damage, investigations on the KP in TBI are scarce. In this study, we comprehensively characterised changes in KP activation by measuring numerous metabolites in cerebrospinal fluid (CSF) from TBI patients and assessing the expression of key KP enzymes in brain tissue from TBI victims. Acute

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13

Catton, Gemma Rachel. "Mechanistic studies on quinolinate phosphoribosyltransferase." Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/485.

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Quinolinate phosphoribosyltransferase (QPRTase, EC 2.4.2.19) is an intriguing enzyme which appears to catalyse two distinct chemical reactions; transfer of a phosphoribosyl moiety from 5-phosphoribosyl-1-pyrophosphate to the nitrogen of quinolinic acid and decarboxylation at the 2-position to give nicotinic acid mononucleotide. The chemical mechanism of QPRTase is not fully understood. In particular, enzymatic involvement in the decarboxylation step is yet to be conclusively proven. QPRTase is neurologically important as it degrades the potent neurotoxin, quinolinic acid, implicated in disease

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14

Tronel, Claire. "Evaluation des effets de molécules à visée neuroprotectrice dans un modèle in vivo de neuroinflammation chez le rat : étude mécanistique et caractérisation du modèle au cours du temps." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR3806/document.

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La mise au point de médicaments ciblant la neuroinflammation, une composante importante de la physiopathologie des maladies neurodégénératives, fait l’objet de nombreuses recherches. Dans ce travail de thèse, nous avons étudié les effets de deux molécules potentiellement anti-inflammatoires et neuroprotectrices : l’hémine, un inducteur de l’hème oxygénase 1(HO-1) et ; le C16, un inhibiteur de la protéine kinase activée par l’ARN (PKR) dans un modèle de neuroinflammation in vivo par injection intrastriatale d’acide quinolinique (AQ) chez le rat. Nos résultats ont montré que l’induction de la HO

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15

Ignarro, Raffaela Silvestre 1987. "Efeito da inibição da enzima JAK2 sobre a morte neuronal, astrogliose e neurogênese no estriado de camundongos adultos após injeção unilateral de ácido quinolínico." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314752.

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Orientadores: Fabio Rogério, Carlos Amilcar Parada<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-18T17:39:33Z (GMT). No. of bitstreams: 1 Ignarro_RaffaelaSilvestre_M.pdf: 3644274 bytes, checksum: 6e13f812b2d525e18878656d3ec27815 (MD5) Previous issue date: 2011<br>Resumo: A injeção de ácido quinolínico (AQ), um agonista glutamatérgico do receptor N-metil-D-aspartato, no estriado de roedores induz morte seletiva de neurônios espinhosos médios, gliose reativa e neurogênese na zona subventricular, acompanhada da migraç

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16

Müller, Adrienne Carmel. "An investigation into the neuroprotective properties of acyclovir." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003254.

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Accumulating evidence suggests that quinolinic acid has a role to play in disorders involving impairment of learning and memory. In the present study, the effect of the guanosine analogue antiherpetic, acyclovir, on quinolinic acid-induced spatial memory deficits was investigated, as well as some of the mechanisms which underlie this effect. Behavioural studies using a Morris water maze show that post-treatment of rats with acyclovir significantly improves spatial memory deficits induced by intrahippocampal injections of quinolinic acid. Histological analysis of the hippocampi show that the ef

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Alves, Catiane Bisognin. "AVALIAÇÃO DO EFEITO PROTETOR DE SINVASTATINA NA FORMA LIVRE E NANOENCAPSULADA EM CONVULSÕES INDUZIDAS POR ÁCIDO QUINOLÍNICO EM RATOS." Centro Universitário Franciscano, 2015. http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/534.

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Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2018-08-16T19:38:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_CatianeBisogninAlves.pdf: 1685484 bytes, checksum: f55dbdb3d23dcf00e605bf4bcddc7bb7 (MD5)<br>Made available in DSpace on 2018-08-16T19:38:00Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_CatianeBisogninAlves.pdf: 1685484 bytes, checksum: f55dbdb3d23dcf00e605bf4bcddc7bb7 (MD5) Previous issue date: 2015-03-06<br>Statins are cholesterol-lowering agents d

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Zheve, Georgina Teurai. "Neuroprotective mechanisms of nevirapine and efavirenz in a model of neurodegeneration." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003285.

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AIDS Dementia Complex (ADC) is a neurodegenerative disorder implicated in HIV-1 infection that is associated with elevated levels of the neurotoxin, quinolinic acid (QA) which causes a cascade of events to occur, leading to the production of reactive oxygen species (ROS), these being ultimately responsible for oxidative neurotoxicity. In clinical studies, Non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP) have been shown to potentially delay the progressive degeneration of neurons, thus reducing the frequency and neurological deficits associated with

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19

Bipath, Priyesh. "Tryptophan and the kynurenine pathway in chronic renal failure patients on dialysis." Diss., Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-10212008-135418.

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Velloso, Nádia Aléssio. "Efeitos da espermina sobre parâmetros motores, cognitivos e neuromorfológicos em um modelo experimental da doença de huntington." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/4402.

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Spermine (SPM) is an aliphatic amine which contains four nucleophilic centers and is found in all eukaryotic cells, including nervous cells. It belongs to the group of polyamines, which are molecules associated with both neuroprotection and neurotoxicity. The aim of this study was to investigate the effects of spermine on some parameters of toxicity induced by striatal administration of quinolinic acid (QA), an experimental model of Huntington s disease in adult and male Wistar rats. The intrastriatal administration of QA (180 nmol/site) induced contralateral rotations and increase the number

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21

Puntel, Robson Luiz. "Efeito de intermediários do ciclo de krebs sobre alterações oxidativas induzidas por diferentes agentes oxidantes." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/11136.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Recent data from the literature have suggested that some Krebs cycle intermediates could act as potent antioxidant agents, both in vitro and in vivo, against a variety of pro-oxidant agents. However, the mechanism(s) involved in the antioxidant effect of Krebs cycle intermediates are not fully understood. Additionally, there are scarce data in the literature taking into account the in vitro effect of Krebs cycle intermediates during oxidative stress conditions. Thus, the aim of this study was to determine the effect of some Krebs c

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22

Tan, Vanessa. "Identification of biomarkers for MND, and understanding the potential role of the cyanotoxin BMAA in neurodegeneration Involvement of Quinolinic Acid in the Neuropathogenesis of amyotrophic lateral sclerosis Detection of the Cyanotoxins L-BMAA Uptake and Accumulation in Primary Neurons and Astrocytes." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS590.

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La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative dévastatrice dont les causes sont inconnues et pour laquelle il n’existe aucun traitement ni marqueur spécifique. Dans ce contexte, nous avons étudié le rôle de la voie métabolique des kynurénines impliquée dans la production de métabolites neuroactifs qui peuvent être immunomodulateurs, neuroprotecteurs ou à l’inverse neurotoxiques. Dans une étude longitudinale du sérum de 66 patients atteints de SLA, nous avons évalué le profil de 10 métabolites de la voie des kynurénines par chromatographie HPLC et spectrographie GC/

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23

Dobrachinski, Fernando. "ASSOCIAÇÃO DO DISSELENETO DE DIFENILA E MODULADORES DO SISTEMA GLUTAMATÉRGICO FRENTE AO DANO OXIDATIVO CAUSADO POR ÁCIDO QUINOLÍNICO." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/11214.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Excessive formation of reactive oxygen species (ROS) and disruption of glutamate uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)- induced toxicity. Thus, here we investigate if the use of diphenyl diselenide (PhSe)2, guanosine (GUO) and MK-801, alone or in combination, could protect rat brain slices from QA-induced toxicity. QA (1 mM) increased ROS formation, thiobarbituric acid reactive substances (TBARS) and decreased cell viability after 2 h of exposure. (PhSe)2 (1 μM) protected against this

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24

Puntel, Robson Luiz. "Caracterização da atividade pró-oxidante de diferentes agentes e estudo do potencial antioxidante de intermediários do ciclo de krebs sobre alterações oxidativas induzidas in vitro." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/4400.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Previous data from the literature have shown that some Krebs cycle intermediates could act as antioxidant in several models, both in vitro and in vivo. However, the mechanism(s) involved in the antioxidant effect of Krebs cycle intermediates are not fully understood. Additionally, there are scarce data in the literature taking into account the in vitro effect of Krebs cycle intermediates during oxidative stress conditions. Thus, the aim of this study was to determine the effect of some Krebs cycle intermediates on lipid peroxidatio

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25

Zehr, Peter S. "Synthesis of novel alkaloids using squaric acid esters." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4411.

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Thesis (Ph. D.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains xvii, 207 p. : ill. Includes abstract. Includes bibliographical references (p. 97-101).

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26

Dobson, Allison J. "X-ray diffraction investigations of quinoline and amino carboxylic acids /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487949836206992.

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Mazzanti, Stefano. "A novel atroposelective strategy for the synthesis of quinoline substrates." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16660/.

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Among heterocyclic compounds, quinoline scaffold has become an important motif for the development of new pharmacological active compounds. Since the discovery of their antimalarial properties, a large variety of quinolines was found to have interesting physiological activities and displayed attractive applications for pharmaceutical industries. In accordance to the above-mentioned features, a number of methods were developed for their synthesis but enantioselective versions are still lacking in the literature. In the past decades, this question has become even more complex, with the emergenc

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García, Aguirre Ana I. "An evaluation of cognitive deficits in a rat-model of Huntington's disease." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8827.

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The purpose of this thesis was to develop methodology by which treatments for the cognitive impairments in Huntington's disease (HD) could be tested. As such, the thesis focused mainly on evaluating rats with quinolinic acid (QA) lesions of the striatum, as this manipulation mimics some aspects of the neural damage in Huntington's disease, to try to identify cognitive deficits of HD resulting from cell loss in the striatum. In the first part (Chapters 3-5), the role of the striatum in implicit memory was investigated. Chapter 3 compared the performance of rats and humans on a reaction time tas

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29

Zhurakovskyi, Oleksandr. "NOVEL DUAL LEWIS ACID - LEWIS BASE BINDERS AS POTENTIAL HYDROGEN AND CARBONYL ACTIVATORS." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/193458.

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A series of new “frustrated Lewis pairs” (FLPs), including chiral versions, with a predefined spatial relationship between the basic and acidic centers is proposed. Several synthetic protocols toward the targets were investigated: through an aryllithium-haloborane coupling; using organotin reagents and a chiral diazaborolidine; and through organoboranes RBH₂ as the boron component. Further development of the project is discussed in light of the discovered data. The intermolecular system consisting of 8-bromo-2-methylquinoline and (C₆F₅)₃B was shown to exist in the form of an FLP. This FLP is n

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Lu, Jianyu. "Syntheses of quinolines as neural protective reagents and progress towards total synthesis of (+) - myriceric acid A." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/27652.

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Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>The first chapter of this dissertation introduces and discusses the syntheses of a series of substituted quinolines as glycogen synthase kinase-3[beta] (GSK-3[beta]) inhibitors. GSK-3[beta] is highly associated with Alzheimer’s disease (AD), and it is suggested that inhibition of this enzyme could alleviate the symptoms of AD. Total 16 novel substituted quinolines were designed and synthesized, and their bio-activities were evaluated on MC65 cell protection assay. Four of the most active compounds were selected to test their enzy

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31

Hu, Xiaobo. "Synthèse, analyses structurales et assemblage de foldamères oligoamide hydrosolubles à base de quinolines." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0611/document.

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La chimie des foldamères est un domaine de recherche en pleine expansion où les chimistes explorent la construction d’architectures artificielles variées mimant les structures repliées des biopolymères naturels. Les foldamères d’oligoamides quinoline, constituent une branche importante des foldamères montrant de nombreuses caractéristiques attractives, incluant la stabilité et la prédictibilité de leurs conformations repliées, qui en font de bons candidats pour des applications biologiques. Jusqu’à présent, la plupart des études sur les foldamères d’oligoamides quinolines ont été menées dans d

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32

Gaver, Charles Richard. "The highly preorganized ligands 8-(2-Pyridyl) Quinoline, 2,2'-dipyridyl amine and 1,10-phenanthroline-2, 9-dicarboxylic acid, and their complexing properties with metal ions." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/gaverc/charlesgaver.pdf.

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Stemper, Jérémie. "Développement d’une nouvelle famille d’acides phosphoriques à chiralité planaire pour l’organocatalyse." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112260.

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Depuis les années 2000 le domaine de l’organocatalyse asymétrique est en plein développement comme le montre le nombre croissant de publications sur le sujet. Durant cet essor un grand nombre d’organocatalyseurs a été développé, ils se classent en quatre catégories : les catalyseurs de transfert de phase, les bases de Lewis, les bases de Brønsted et les acides de Brønsted. Appartenant à cette dernière catégorie, les acides phosphoriques chiraux font partie des acides de Brønsted les plus populaire. Leurs premières utilisations en organocatalyse asymétrique remontent à 2004 où des acides phosph

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Marques, Naiani Ferreira. "Centella asiática REDUZ PEROXIDAÇÃO LIPÍDICA INDUZIDA POR ÁCIDO QUINOLÍNICO E NITROPRUSSIATO DE SÓDIO IN VITRO EM REGIÕES DO CÉREBRO DE RATO." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/11242.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The oxidative stress is envolved in several diseases, including neurological diseases. Centella asiatica is a medicinal plant which was has long been used to treat neurological disturbances in Ayurvedic medicine. The aim of this study was to evaluate the antioxidant potencial of different extracts of C.asiatica in vitro. Were quantified by High Performance Liquid Chromatograph (HPLC) the present compounds and examined the phenolic content of the infusion and fractions: ethyl acetate, n-butanol and dichlorometane. Furthermore, the a

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35

Goes, Tiago Costa. "Efeito do enriquecimento ambiental e da lesão do cortéx pré-frontal medial nos níveis de ansiedade-traço e -estado." Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3614.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Effect of environmental enrichment and lesion of the medial prefrontal cortex in the trait and state anxiety levels. Tiago Costa Goes, Aracaju – SE, 2016. In the study of anxiety, there are two distinct concepts: state and trait anxiety. State anxiety is the anxiety a subject experiences at a particular moment in time, it is transitory and may be affected by external stimuli; whereas trait anxiety is considered an enduring feature of an individual, it is relatively stable over time and a predisposing factor for anxiety diso

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"Enantiospecific synthesis of valiolumine and its diastereoisomers from (-)-quinic acid." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5887291.

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Wan Leong Hang.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 80-83).<br>Acknowledgments --- p.i<br>Bibliography --- p.ii<br>Contents --- p.iii<br>Abstract --- p.iv<br>Abbreviations --- p.v<br>Chapter I --- Introduction<br>Chapter I-1 --- General Background of Pseudo-sugar --- p.1<br>Chapter I-2 --- Monocarba-sugar --- p.2<br>Chapter I-3 --- Dicarba-sugar --- p.4<br>Chapter I-4 --- Isolation of Valiolamine and Its Related Compounds --- p.6<br>Chapter I-5 --- Previous Syntheses of Valiolamine --- p.8<br>Chapter II --- Result

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"Enantiospecific syntheses of cyclophellitol and its analogues from (-)-quinic acid." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5887850.

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by Vincent Wing-Fai Tai.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.<br>Includes bibliographical references (leaves 79-83).<br>Acknowledgements --- p.i<br>Contents --- p.ii<br>Abstract --- p.iii<br>Abbreviations --- p.iv<br>Chapter I --- Introduction<br>Chapter I-1 --- General Background --- p.1<br>Chapter I-2 --- Review on Epoxycyclohexanes --- p.2<br>Chapter I-3 --- Mechanistic Aspect of Glycosidase Inhibitors --- p.5<br>Chapter I-4 --- Previous Synthesis of cyclophellitol and its diastereoisomers 1-4 --- p.12<br>Chapter II --- Results and Discussion<br>Chapter II-l -

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"A thesis, in two parts, entitled part A, Enantiospecific syntheses of cyclophexane oxides from (-)-quinic acid, part B, Ruthenium catalyzed cis-dihydroxylation of alkenes." Chinese University of Hong Kong, 1996. http://library.cuhk.edu.hk/record=b5888854.

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by Eric Kwok Wai Tam.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1996.<br>Includes bibliographical references.<br>Table of Contents --- p.i<br>Acknowledgement --- p.iv<br>Abstract --- p.v<br>Abbreviation --- p.vii<br>Part A<br>Enantiospecific Syntheses of Cyclohexane Oxides from (-)-Quinic Acid<br>Chapter 1. --- Synthetic Application of (-)-Quinic Acid --- p.1<br>Chapter 1.1 --- Introduction --- p.1<br>Chapter 1.2 --- Syntheses of Cyclohexane Derivatives --- p.2<br>Chapter 1.2.1 --- Syntheses of Shikimic Acid (2) and its Derivatives --- p.2<br>Chapter 1.2.2 --- "Syntheses of D

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Strauss, Ian. "Proton magnetic resonance spectroscopic imaging of acute and chronic neuronal damage in the rat induced by quinolinic acid /." 1996. http://wwwlib.umi.com/dissertations/fullcit/9701375.

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Zheve, Georgina Teurai. "Neuroprotective mechanisms of nevirapine and efavirenz in a model of neurodegeneration /." 2007. http://eprints.ru.ac.za/1350/.

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Huo, Lu. "Structural and Mechanistic Studies on α-Amino β-Carboxymuconate ε-Semialdehyde Decarboxylase and α-Aminomuconate ε-Semialdehyde Dehydrogenase". 2014. http://scholarworks.gsu.edu/chemistry_diss/100.

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α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) and α-aminomuconate-ε-semialdehyde dehydrogenase (AMSDH) are two neighboring enzymes in the L-tryptophan and 2-nitrobenzoic acid degradation pathways. The substrates of the two enzymes, α-amino-β-carboxymuconate-ε-semialdehyde (ACMS) and α-aminomuconate-ε-semialdehyde (2-AMS), are unstable and spontaneously decay to quinolinic acid and picolinic acid, respectively. ACMSD utilizes a divalent zinc metal as cofactor and is a member of the amidohydrolase superfamily. In this dissertation work, we have identified an important histidine

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O'Connell, Adam Brett. "Development of an acute excitotoxic model of Huntington's disease in sheep." Thesis, 2020. http://hdl.handle.net/2440/127292.

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Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The earliest and most severe neuropathological change in HD occurs within the striatum. Exogenous excitotoxic lesioning of the rodent and non-human primate (NHP) striatum is used to model HD. Apart from NHPs, no other excitotoxic large animal model of HD has been established. Sheep have the potential to be an important species for modelling neurodegenerative disease, primarily because of neuroanatomical similarities between the sheep and human brain. This thesis describes the development of an excitotoxic sheep mode

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Chang, Jia-Hen, and 張嘉恆. "Supramolecular Au(I) Compounds Containing Trithiocyanuric acid or Quinoline-8-thiolate." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/6qkcmp.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>105<br>In the literature, most of the closed-shell d10 gold(I) complexes containing phosphine or thiolate ligands, show intriguing structural and spectroscopic properties. In this thesis, we used AuClPMe3 and AuClPEt3 (PMe3 = trimethylphosphine；PEt3 = triethylphosphine) to react with thiolate ligands H3N3S3 (Trithiocyanuric acid) and H8-QNS (Quinoline-8-thiolate) to construct dinuclear, trinuclear, and hexanuclear gold(I) compounds. Crystal structures of compound 1-4 are determined by single-crystal X-ray crystallography, [(N3S3)Au(AuPMe3)2]2‧2CH2Cl2 (1), [(N3S

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Yeh, Mei-Chun. "Synthesis of quinoline-fatty acid conjugates and characterization of their immunomodulatory properties." Thesis, 2010. http://hdl.handle.net/2440/121656.

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The anti-malarial chloroquine (CQ) and derivatives are useful anti-inflammatory agents which have been useful in treating patients with rheumatoid arthritis and systemic lupus erythromytosus. Nevertheless derivatives of CQ, such as hydroxychloroquine (HCQ) have been made to reduce the toxicity and increase the potency of the drug. We have approached this challenge by synthesizing 13 quinoline based compounds bearing a saturated or un-saturated fatty acid side chain (carbon chain length of 3 to 20). Examination of their immunomodulatory properties in vitro at concentrations up to 50μM showed th

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Cheng, Lin-Chieh, and 鄭琳潔. "Cu-Catalyzed Aerobic Oxidation in the Synthesis of Quinolinium Salts from Secondary Amines, Alkynes, Formaldehyde and Acid." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/dg5crz.

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碩士<br>國立清華大學<br>化學系所<br>106<br>Substituted heterocyclic nitrogen salts are versatile building blocks for a number of natural products and bioactive motifs. Herein, we report a novel and convenient process to synthesize quinolinium salt derivatives by Cu-catalyzed aerobic oxidative coupling of secondary amine, alkyne and formaldehyde. The reaction proceeds via acid induced N,N-disubstituted iminium ion formation followed by nucleophilic addition of alkyne, annulation, and copper-promoted oxidation. This method features an economical catalyst, one pot process, ambient reaction temperature and sh

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Chou, Chein-an, and 周建安. "Complexation of camphor sulfonic acid to affect the emission behavior of organic compound and polymer with quinoline moiety." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/09652709812360188133.

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碩士<br>國立中山大學<br>材料與光電科學學系研究所<br>98<br>Many chromophoric organics and polymers are highly emissive in their dilute solutions but become weakly luminescent in the high concentration and solid film states due to the induced π−π interactions of the intimately-contact chromophores. Therefore, it is practically important to develop fluorescent organic and polymeric materials with enhanced emission in their aggregated states (so called aggregated-induced emission, AIE). In this study, organic compound 2,4-diphenylquinoline (DPQ) with inherent quinoline ring a

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Rong, Dawen, Victoria A. Phillips, R. S. Rubio, Castro M. Angeles, and Richard T. Wheelhouse. "A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea-hydrogen peroxide." 2008. http://hdl.handle.net/10454/6160.

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A novel, convenient, and high-yielding method has been developed for the preparation of heterocyclic N-oxides. The reaction uses the urea·hydrogen peroxide addition complex as a peroxide source for the in situ generation of trifluoroperacetic acid. The advantages of this method are easy handling of a stable, solid oxidant; high yields and simple removal of excess reagents and by-products.

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Wang, Yi-Ju, та 王以如. "具關節炎用藥潛能之2-Quinoline-4-carboxylic Acid類似物之合成". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/59577328372717768347.

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Лагрон, Аліса Вадимівна. "Синтез і властивості 4-гідразинохінолінів та їх іліденогідразинопохідних". Магістерська робота, 2020. https://dspace.znu.edu.ua/jspui/handle/12345/4201.

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Лагрон А. В. Синтез і властивості 4-гідразинохінолінів та їх іліденогідразинопохідних : кваліфікаційна робота магістра спеціальності 102 "Хімія" / наук. керівник О. А. Бражко. Запоріжжя : ЗНУ, 2020. 72 с.<br>UA : В роботі 72 сторінки, 2 таблиці, 38 рисунків, було використано 65 літературних джерела, 20 з них на іноземній мові. Об’єктом дослідження є (хінолін-4-ілгідразон)-карбонові кислоти та їх функціональні похідні. Предметом дослідження є синтез, ідентифікація та фізико-хімічні властивості (хінолін-4-ілгідразон)-карбонових кислот та їх солей, естерів (температура плавлення, ТШХ). Мета

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