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Oksuz, Arif. "Software Development For R/c Building Vulnerability Index And Member Importance Calculation." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12604847/index.pdf.
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SOFTWARE DEVELOPMENT FOR
R/C BUILDING VULNERABILITY INDEX
AND MEMBER IMPORTANCE CALCULATION
Turkey has many active faults which have the potential to generate large
earthquakes. Recent earthquakes showed that the buildings in Turkey are not well
designed and vulnerable to earthquakes. Previous studies on the subject showed
that many structures in Turkey need to be strengthened before the next major
earthquake to minimize property loss and casualties.
A number of fast and approximate (mostly empirical) methods have been
developed in the past to process large building stock. However, there are some
important and special structures that do not fit with the general building stock and
needs special consideration (e.g., disaster management center, governmental
buildings, hospitals, tall structures, etc.). This study targets to evaluate those
important and special structures in a detailed, fast, and correct manner. The
developed software, which constitutes an important part of this study, does process
the building information several times to determine member-based importance
factors. The vulnerability index of the building will be determined using the importance of each load-carrying member and how much each member is forced
with respect to its capacity.
In order to augment user perception, a functional graphical user-interface is
designed. Software is equipped with modules that generate input files for SAP2000
analysis program, conduct dynamic and static analysis automatically, and postprocess
the generated analysis results which enable the engineer to make a
decision on the vulnerability of the structure. Program is written in C++, using
object-oriented programming technique.
The main difference between this and similar studies is the generator
program which automatically generates 3D-FE models and post-processes nonlinear
analysis results for an effective decision mechanism. In this way, more
realistic results can be obtained much faster.
As future studies, new routines are planned to be implemented to the
graphical user interface of the program which will suggest smart and engineered
retrofit/strengthening alternatives to the user.
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Yalim, Baris. "Internet Based Seismic Vulnerability Assessment Software Development For R/c Buildings." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605599/index.pdf.
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Structural evaluation and seismic vulnerability assessment of Reinforced Concrete (R/C) buildings have especially become the focus of many researches in Turkey and abroad especially after the August 17, 1999 earthquake causing major life and property losses. A devastating earthquake being expected in Istanbul-Marmara region raises many questions on how well the existing buildings are constructed and whether they can stand a major earthquake. Evaluation of existing buildings for seismic vulnerability requires time consuming input preparation (pre-processing), modelling, and post processing of analysis results. The objective of the study is to perform automated seismic vulnerability assessment of existing R/C buildings automatically over the internet by asking internet users to enter their building related data, and streamlining the modelling-analysis-reporting phases by intelligent programming. The internet based assessment tool is prepared for two levels of complexity: (a) the detailed level targets to carry out seismic evaluation of the buildings using a linear structural analysis software developed for this study<br>(b) the simplified level produces seismic evaluation index for buildings, based on simple and easy to enter general building information which can be entered by any person capable of using an internet browser. Detailed level evaluation program includes a user friendly interface between the internet user and analysis software, which will enable data entry, database management, and online evaluation/reporting of R/C buildings. Building data entered by numerous users over the internet will also enable formation of an extensive database of buildings located all around Turkey.
36 buildings from Dü<br>zce damage database, generated by the cooperation of Scientific and Research Council of Turkey (TÜ<br>BiTAK) and Structural Engineering Research Unit (SERU) after the 17 August 1999 Kocaeli and the 12 November 1999 Dü<br>zce earthquakes, are used in the analyses to identify relationship between calculated indices and observed damage levels of buildings, which will enable prediction of building damage levels for future earthquakes. The research is funded by Science Research Program (BAP 2003-03-03-03), NATO-SfP 977231, and TUBITAK ICTAG-I574 projects.
The contribution of the research is composed of a) online building index -performance analysis/evaluation software which might be used by any average internet user, b) an ever-growing R/C building database entered by various internet users.
3
Demirok, Emel. "3d-fe Model Field-calibration And Rating Studies On Existing R/c Buildings." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607223/index.pdf.
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Dynamic instrumentation and a series of ambient vibration tests were performed on a four storey strengthened R/C building within the scope of this study. Traffic load and wind load were accepted as natural dynamic loads and the vibrations were recorded by sensitive accelerometers.For that study, 12 uniaxial, 1 triaxial accelerometers and a 15 channel data logger system were used.
Four sets of dynamic measurements were recorded over a period of 6 months. Recorded readings were analyzed using UPC, PC and CVA algorithms and Artemis software. The natural freqeuncies, mode shape of the tested building were determined. The experimental results were compared against each other. A 3D-FE model of the building was prepared and analytical results were also compared against experimental results.The calibration (updating) of the analytical model was carried out using the experimentally obtained mode shapes and freqeunices.
The results of the study indicate that first few mode shapes and freqeuncies of the building can be obtained successfully within zero to 10 Hz range using ambient monitoring. Field calibrated FE models can effectively simulate the first translational and torsional modes of the building. Calibration studies indicate that the upper floor is more flexible than the nominal model and there are weaknesses between the shear wall and roof slab connections.
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STADLER, MICHAEL. "Proteines de la structure r b c c et transcription." Paris 7, 1999. http://www.theses.fr/1999PA077260.
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Les proteines r b c c sont caracterisees par la presence, de l'aminoterminus au carboxyterminus, des trois motifs ring, boite b et coiled coil. Le doigt de zinc du type ring (c 3hc 4) fait partie des interactions intermoleculaires dans des complexes multiproteiques et pourrait jouer un role dans leur assemblage ou stabilisation. Il est aussi responsable, en collaboration avec la boite b, de la localisation compartementalisee subcellulaire des proteines. Le doigt de zinc du type boite b (chc 3 - 4h 2) est implique dans des interactions proteine-proteines, par exemple dans la liaison de pml a rb1. Le domaine de dimerisation par helices hydrophobes (coiled coil) est une super-helice des helices et participe a la dimerisation, ensemble avec la boite b : le coiled coil comme surface d'interaction, la boite b peut-etre comme stabilisateur de l'orientation du coiled coil. Les trois domaines constituent le motif tripartie qui semble jouer un role fondamental dans l'adressage ou l'assemblage des macromolecules. Les membres les mieux etudies de cette famille multiproteique sont pml et les tif1. Pml est une proteine avec des capacites multiples de regulation : elle fait partie des complexes transcriptionnellement actifs, elle reprime (a travers l'apoptose) la croissance et la transformation, et elle controle des fonctions immunitaires, sous influence de l'acide retinoique et des interferons. Nous avons pu eclaircir le mecanisme moleculaire de l'induction transcriptionnelle de pml par les interferons avec l'identification d'elements fonctionnels de reponse aux interferons dans le promoteur de pml. Pml est fusionne au recepteur de l'acide retinoique, rar dans la translocation t(15 ; 17) specifiquement rencontree dans la vaste majorite
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Vafadar, Afshar Rita. "Using ObjectStore in building C++ interface application." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ47854.pdf.
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Maingot, Stéphane. "Sur l'extension des fonctions C R." Paris 11, 1985. http://www.theses.fr/1985PA112345.
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Dans cette thèse, on considère M, une sous-variété C R de CN, passant par 0 et on donne des conditions suffisantes, liées à la forme de Levi en 0, pour que toutes fonction C R sur ω, un voisinage ouvert de 0 dans M, soit la restriction à ω d’une fonction holomorphe au voisinage de 0 dans CN. La méthode utilisée consiste en la construction de disques analytiques dont le bord est sur M et qui contiennent un voisinage de 0 dans CN, d’abord dans un cas modèle puis dans la cas général par approximations<br>In this thesis, we consider M, a CR submanifold of ₵N, which passes through 0, and, we give sufficient conditions, related to the Levi form at the origin, so that each C R function on ω, an open neighborhood of 0 in M, is the restriction to ω of a holomorphic function defined on an open neighborhood of 0 in ₵N. The method used is to construct analytic discs whose boundaries lie on M and which contain a neighborhood of 0 in ₵N, first in a model case, then in the general case by approximations
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Guo, Xiangyu. "Ruthenium-catalyzed C-C bond formation via functional-group directed C-H bond activation." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110570.
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AbstractRuthenium-Catalyzed C-C Bond Formation via Functional-Group Directed C-H Bond ActivationXiangyu GuoAdvisor: Prof. Chao-Jun LiMcGill UniversityThis thesis is an investigation on the formation of carbon-carbon (C-C) bonds in the presence of ruthenium catalyst.In the first part of this thesis, oxidative dehydrogenative coupling reactions for carbon-carbon (C-C) bond formation are described. A ruthenium-catalyzed dimerization of 2-phenylpyridine derivatives is demonstrated to synthesize biaryls using iron(III) chloride as the terminal oxidant. In addition, the oxidative cross coupling of arenes and cycloalkanes is also illustrated, achieving a unique para-selectivity.In the second part of the thesis, a ruthenium-catalyzed olefination via decarbonylative addition of aldehydes to terminal alkynes is described. Conjugated and isolated C=C bonds can be chemoselectively generated in two catalytic systems starting from aromatic and aliphatic aldehydes. The method provides an alternative synthesis of C=C bonds from direct C-H bond addition to triple bonds.<br>RésuméRuthenium-Catalyzed C-C Bond Formation via Functional-Group Directed C-H Bond ActivationXiangyu GuoSuperviseur: Prof. Chao-Jun LiUniversité McGillCette thèse est le résultat de la recherche sur la formation de liaisons carbone-carbone (C-C), catalysé par le ruthénium. La première partie de cette thèse expose les résultats sur la formation de liaison carbone-carbone (C-C) par la réaction de couplage oxydant par déshydrogénation. La synthèse de composés biaryl par l'utilisation d'un catalyseur de ruthénium a permis la dimérisation des dérivés de la 2-phénylpyridine en présence de chlorure de fer (III) comme oxydant terminal. En outre, l'oxydative cross-coupling entre arènes et cycloalcanes, a montrer une notable, para-sélectivité. La seconde partie de cette thèse, décrit les résultats obtenue sur la réaction d'oléfination decarbonylative entre un aldéhyde et un alcyne vrai, catalyser par le ruthénium. En partant d'aldéhydes aromatiques ou aliphatiques et par l'utilisation de deux systèmes catalytiques, la synthèse chemioselective de double liaison C=C conjuguée ou isolée ont pu être réalisé. Cette réaction fournit ainsi, une intéressante alternative à la synthèse de doubles liaisons C=C par la directe addition de liaison C-H sur une triple liaison.
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Correia, Camille. "Oxidative C-C bond formation via metal-catalyzed coupling of two C-H bonds." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114441.
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This thesis describes the formation of new C-C bonds from the direct oxidative coupling of two C-H bonds, through the use of metal catalysts for activation. First, three different oxidative Cross-Dehydrogenative-Coupling (CDC) reactions will be presented. Initially, through the use of an organic co-catalyst, N-hydroxyphthalimide (NHPI), oxygen could be utilized as the terminal oxidant for the metal catalyzed alkylation of benzylic C-H bonds with 1,3-dicarbonyls and ketones in Chapter 2. The reaction was found to be feasible for a variety of substrates with readily enolizable C-H bonds. Next, the 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated alkynylation of sp3 C-H bonds was studied. A novel copper (I) triflate catalyzed CDC reaction of unactivated benzylic C-H bonds and terminal aromatic alkynes is presented in Chapter 3. After further studies, the alkynylation of benzylic ethers could also be realized in the presence of a catalytic amount of silver (I) triflate, as described in Chapter 4. Both procedures were found to be amendable for aromatic terminal alkynes, however could not be extended to aliphatic alkynes. Finally, a palladium catalyzed Minisci-type reaction will be described in Chapter 6. Peroxide generated α-hydroxyalkyl radicals could be reacted with azines in moderate to good yields. A stoichiometric amount of acid, used in the traditional Minisci reaction, was replaced by a catalytic amount of palladium dichloride.<br>Cette thèse décrit la formation de nouvelles liaisons C-C par activation oxydative directe de deux liaisons C-H grâce à l'utilisation de métaux de transition comme catalyseurs. La première partie présentera trois différentes réactions de Cross-Dehydrogenative-Coupling (CDC) oxydantes. Dans un premier temps, sera présentée dans le chapitre 2, la réaction d'alkylation de liens C-H benzylique par 1,3-dicarbonyles et cétones. Ce system a démontré son efficacité sur une large variété de substrats contenant des liaisons C-H enolysable. De plus il a été rendu possible, grâce à l'utilisation d'un co-catalyseur organique, le N-Hydroxyphthalimide (NHPI), d'utiliser l'oxygène moléculaire comme oxydant terminal. Dans un second temps, nous étudierons l'utilisation du 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) comme médiateur pour l'alkynylation de liaisons sp3 C-H. Une nouvelle CDC réaction catalysée par le triflate de cuivre (I) sera présentée dans le chapitre 3, entre un alcyne et une liaison C-H benzylique. Le chapitre 4 présentera le développement de cette réaction à l'alcynation d'éthers benzyliques en présence d'une quantité catalytique de triflate d'argent (I). Ces deux procédures sont seulement applicables pour les alcynes vrais aromatiques. Finalement, le chapitre 6 portera sur la réaction de Minisci catalysée par le palladium. Le peroxyde radical α-hydroxyalkyl généré lors de la réaction est capable de réagir avec les azines. La quantité stœchiométrique d'acide nécessaire lors de la traditionnelle réaction de Minisci, a été remplacée par une quantité catalytique de dichloro palladium.
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Hashim, Khairuddin. "A preprocessor building system for the C language." Thesis, University of Bath, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233580.
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Johnston, Jean-Michel. "The moods of modernity : Germany in the age of telegraphy, c.1830-c.1880." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:2054eff2-ca29-4326-bc27-a79396f6de6a.
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This thesis investigates the origins and impact of electrical telegraphy in Germany between 1830 and 1880, situating them within the context of long-term transformations in the theory and practice of communication. It uses the development of telegraphy as an analytical lens through which to explore the connections between actors at the heart of the socio-economic transformations taking place in Germany during the period. Both as an innovation and as a tool of communication, this thesis argues, the telegraph epitomised the simultaneously growing interdependence and differentiation between people and places which was a defining characteristic of modernity. By exploring the motivations and interactions of scientists, entrepreneurs, state officials, and ordinary users who engaged with the technology, this thesis highlights the diverse expectations which were placed upon telegraphy, and the many different directions in which its development was pulled. In doing so, it reveals the ties between the âmodernisingâ processes with which the technology has been associated. It challenges linear narratives of technological innovation which focus exclusively upon individual or state actors, emphasising the cooperation and collaboration across society which was necessary to produce the telegraph. It similarly questions triumphalist interpretations of the 'communications revolution' so often attributed to the nineteenth century, emphasising instead the tensions and divisions which it also generated. Revisiting the themes of industrialisation, capitalism, community and bourgeois class-formation in nineteenth-century Germany in this light, this thesis emphasises their intrinsic interdependence, and the inevitable mixture of hopes and anxieties, expectations and frustrations, which it produced.
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Herberholz, Miriam. "Auswirkungen von Tenascin–C, –R und –C/R–Defizienz auf den skelettalen Phänotyp von Mäusen mit hohem Lebensalter." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-48935.
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Coupiat, Pierre. "B-e-r-g-e-r-a-c,. . . Archipel pavillonnaire." Bordeaux 2, 2009. http://www.theses.fr/2009BOR21605.
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La petite ville s'est transformée au point que seuls les anciens s'en souviennent encore et narrent une ville qui désormais a disparu. Le plus remarquable est la séparation du politique et du système d'intégration à la ville désormais ouvert au système marchand. L'unité de la ville s'efface alors au profit de la qualité de séparation. Dans ce contexte, l'habitant en tant que statut disparaît au profit de l'habitant qualité qui s'acquiert. La petite ville n'est plus qu'un "habit vide" et les relations entre les individus s'effectuent ailleurs. Plus précisément, à partir d'un "archipel pavillonnaire" et donc dans des îlots séparés et différenciés socialement. Nous argumentons donc pour une séparation des univers sociaux à l'instar des territoires urbains et plus précisément des villes américaines. Les habitants vivent dans des groupes sociaux inclusifs organisés sur une base spatiale. L'archipel pavillonnaire est alors un monde de la complexité dans lequel l'individualisation et la séparation en formulent l'expérience. En définitive, dans l'archipel pavillonnaire, la qualité de séparation, la faiblesse des liens et l'évitement des conflits constituent un ordre moral singulier : le minimalisme moral<br>The little town has changed so much that only the elderly can remember it and tell the story of bygone days. What is worth noting is the separation between politics, and the town system of integration now open to free trade. The town unity is replaced by the quality of separation. In these circumstances, the inhabitant as status steps aside in favor of the inhabitant as quality, which can be acquired. The small town is merely an empty garment and the relationships between inhabitant are elsewhere, more precisely from a residential area in socially separate places. We therefore advocate for a separation of social universes following the example of urban territories and more precisely American cities. The inhabitant live in inclusive social groups organized on a spatial basis. The suburban area is then a world of complexity in which individualization and separation express this experience. In other words, in the suburban area, the quality of separation, the weak ties and the avoidance of conflicts compose a peculiar moral order : the moral minimalism
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Carlyle, Margaret. "Cultures of anatomy in enlightenment France (c.1700-c.1795)." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114315.
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This thesis provides a cultural history of anatomy in Enlightenment France (c. 1700-c.1795). It tells the overlapping stories of the rise of anatomy as a public, polite, and sociable science experienced by gentlemanly amateurs and of anatomy's consolidation as a dynamic experimental branch of natural history. The first narrative explores how eighteenth-century anatomy gained amateur adherents through textbooks, three-dimensional objects, spectacular courses, and tutors. The second offers an account of how anatomists transformed their field into a viable, utilitarian, and socially useful research discipline. This project makes contributions to the histories of science, Old Regime France, and gender, and the social history of medicine. It shows how Enlightenment anatomy enlisted a distinctive set of places, objects, and peoples. First, anatomy was produced, packaged, and disseminated to consumer audiences in traditional scholarly and pedagogical spaces, but also outside them, in venues of learning that included the court, commercial districts, museums, public spaces, private chambers, amphitheatres, and cabinets. Second, anatomical knowledge was created, conveyed, and ratified in these settings using familiar materials like corpses, as well innovative artificial materials like wax, wicker, glass, and textiles. The material culture of anatomy was inscribed in the worlds of amateur appreciation and experimental practice, where tourism played an important role in the exchange of goods and know-how. Finally, those who practised anatomy and the public which digested it achieved new recognition during this period and collectively contributed to shaping the form and content of anatomical knowledge. The result was that eighteenth-century anatomy accommodated a broader range of individuals – men and women, amateurs, medical practitioners, artists, and artisans – than ever before.<br>Cette thèse examine l'histoire culturelle de la science anatomique dans la France au siècle des Lumières (c.1700-c.1795). En adoptant une approche culturelle, elle étudie à la fois l'émergence de l'anatomie comme science liée à la mondanité, pratiquée par des amateurs appartenant à l'élite, ainsi que la formalisation de la discipline anatomique en tant que domaine expérimental de l'histoire naturelle. En premier lieu, cette thèse explore comment l'anatomie, à l'aide de manuels, d'objets tridimensionnels, de leçons publiques et de tuteurs, a attiré des disciples amateurs. En second lieu, elle démontre comment les anatomistes ont transformé leur champ en une discipline scientifique viable et utile pour leur société. Cette double analyse contribue donc à l'histoire des sciences, de la France d'Ancien Régime, du genre, ainsi qu'à une histoire sociale de la médecine. Cette thèse tente de démontrer comment la discipline anatomique telle que pratiquée au cours des Lumières réunissait un ensemble distinct de pratiques, d'objets et de personnes. D'abord, le savoir anatomique était produit, accumulé et disséminé au public dans des espaces pédagogiques et académiques traditionnels mais également, au-delà de ceux-ci, dans des espaces d'apprentissage plus larges qui incluaient la cour, des musées, des espaces commerciaux, des espaces publics tout comme des chambres privées ainsi que des amphithéâtres et des cabinets. Ensuite, le savoir anatomique était créé, transmis et confirmé dans ces espaces en utilisant des matériaux familiers tels que des corps, mais aussi des matériaux artificiels novateurs tels que la cire, l'osier, le verre et les textiles. Ainsi, la culture matérielle de la science anatomique s'est inscrite en lien avec la culture amateur de l'appréciation et la pratique expérimentale, où le tourisme jouait un rôle important pour l'échange d'objets et de savoirs. Finalement, les anatomistes, et leur public, ont acquis un nouveau degré de reconnaissance au cours du siècle des Lumières et ont, ensemble, contribué au développement du savoir anatomique tant au niveau de la forme que du contenu. Ces transformations ont permis à un plus grand nombre d'individus d'origines diverses – hommes, femmes, amateurs, médecins, artistes, artisans – de se familiariser avec l'anatomie.
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Adams, Jane M. "The mixed economy for medical services in Herefordshire c. 1770 - c. 1850." Thesis, University of Warwick, 2003. http://wrap.warwick.ac.uk/2640/.
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This study considers the mixed economy for medical services in Herefordshire between 1770 and 1850. Medical services were an integral part of wider systems of welfare and were provided within a mixed economy that included private practice, state provision, philanthropic activities and mutual societies. Significant resources were spent within the sector and influence over their deployment was of direct interest to parishes, the municipal council, magistrates, philanthropists and individual members of the elite. Four types of medical services are reviewed. These are the provision of personal care by medical practitioners in the private, public and charitable sectors, the establishment of Hereford General Infirmary, changes in institutional services for the insane and developments in public health. Two underlying themes are discussed throughout the thesis. The first of these is the complexity of the mixed economy for medical services. Important changes over the period are identified and the interrelationships between the various sectors investigated. The dominance of public, private or charitable provision shifted in the period as a result of both national and local factors. The second theme explored is the interplay between politics and the systems and institutions providing medical services. The importance of political considerations in shaping local policy towards medical services is demonstrated through detailed case studies. These include examining the link between the launch of the subscription appeal for Hereford Infirmary and the parliamentary election campaign in 1774, approaches taken towards the management of the cholera epidemic of 1832 and the campaign to establish a public lunatic asylum in the late 1830s.
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Rigg, Suzanne. "Scots in the Hudson's Bay Company, c.1779 - c.1821." Thesis, University of Aberdeen, 2008. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU511840.
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This dissertation examines Scottish involvement in the Hudson's Bay Company (HBC), c.1779 to c.1821. It surveys the Company's recruitment practices, and the national and regional contribution of Scots to the HBC, demonstrating that Orkneymen were disproportionately numerous throughout the entire period under examination. This study explores their motivation for entry to the HBC, and the various routes (and obstacles) to advancement of salary and station. It also seeks to establish whether Scottish networks operated in the fur trade, and the utility of such connections. Although Scots encountered many opportunities for betterment in Rupert's Land, they were also confronted with the challenge of working in a commercially competitive and remote wilderness environment. Extreme climatic conditions, insufficient food/medicinal supplies, laborious work duties, and violent trade rivalry meant that illness, disability, and death were common occurrences. The extent to which the paternalistic directors endeavoured to mitigate such hardships, and tended to the welfare of employees and their dependents, is assessed. Finally, the social, cultural and economic impact of Scots on both their temporary and home residences is explored. This discussion includes the significance of 'Scottishness' in the fur trade and the importance of 'home' to temporary migrants. In addition, this study highlights the difficulties of remitting savings and domestic support money to dependents in Scotland, and the successes of employees who fulfilled their personal ambitions on their return to Orkney, and climbed onto the property ladder.
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El, Naggar Ossama. "Approaches to the syntheses of c-substituted-a-amino-c lactones." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65948.
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Campbell, Bruce Donald. "Experimental tests of C-S-R strategy theory." Thesis, University of Sheffield, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279651.
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Gomes, Bernardo Paschoarelli Veiga. "Sobre o closing lemma de classe C^r." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-02022007-133405/.
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Neste trabalho reunimos alguns resultados afirmativos relacionados ao closing lemma de classe C^r em variedades bidimensionais compactas.<br>In this work we present some partial results corcerning closing lemma for smooth flows on compact bidimensional manifolds.
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Harinck, Pascale. "Fonctions generalisees spheriques sur g(c)/g(r)." Paris 7, 1988. http://www.theses.fr/1988PA077186.
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On considere un espace symetrique semi-simple g/h ou g est un groupe de lie semi-simple complexe et h une forme reelle de g. On etudie les fonctions h-invariantes sur g/h qui sont solutions propres des operateurs differentiels g-invariants sur g/h. De telles fonctions sont dites spheriques. Dans la premiere partie, nous montrons qu'une fonction generalisee spherique sur un ouvert h-invariant v de g/h est une fonction localement integrable sur v et analytique sur l'ensemble des points reguliers de v. Nous donnons egalement des conditions suffisantes pour qu'une fonction h-invariante et localement integrable sur g/h soit spherique. Dans la deuxieme partie, on suppose que l'algebre de lie h de h admet une sous-algebre de cartan compacte t. On note t le sous-ensemble de cartan associe a t. On montre qu'une fonction generalisee spherique sur g/h est determinee par sa restriction a t. Ensuite, a partir d'une fonction generalisee h-invariante et temperee f sur h qui est solution propre des operateurs differentiels h-invariants a coefficients constants sur h, on construit une fonction generalisee spherique f' sur g/h. Lorsque la fonction f est la transformee de fourier de l'orbite d'un element regulier elliptique du dual de h sous l'action de la representation coadjointe de h, on obtient une serie continue de fonctions generalisees spheriques sur g/h. Sur un exemple, on montre comment cette serie continue intervient dans la formule d'inversion pour g/h. Ceci donne un lien entre l'analyse harmonique sur g/h et la methode des orbites
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Harinck, Pascale. "Fonctions généralisées sphériques sur G(C)/G(R)." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37614310p.
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Kenrick, David William. "Pioneers and progress : white Rhodesian nation-building, c.1964-1979." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a9e3ff0d-dfca-4e19-8adc-788c3e7faf9f.
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The thesis explores the white Rhodesian nationalist project led by the Rhodesian Front (RF) government in the UDI-period of 1965 to 1979. It seeks to examine the character and content of RF nation-building, arguing that it is important to consider the context of wider global and regional trends of nationalism at the time. Thus, it places the white Rhodesia within wider 'British World' studies of settler societies within the British Empire, but also compares it to other African nationalist movements in the 1960s and 1970s. It studies white Rhodesian nationalism on its own terms as a sincere, albeit unrealistic, alternative to majority-rule independence, and considers how the RF adapted over the period in its continuing attempts to justify minority-rule in an era of global decolonisation. Two thematic sections examine the RF's nation-building project in systematic detail. The first section, on symbolism, considers Rhodesia's processes of 'symbolic decolonisation'. This involved white Rhodesians creating new national symbols not associated with Britain or the British Empire. Processes by which new national symbols were chosen are used as a lens to explore white Rhodesian debates about their 'new' nation after the Unilateral Declaration of Independence (UDI) was taken in 1965. They reveal the ambiguities and complexities at the heart of the RF's nation-building project; a project that was frequently exclusionary and hotly contested at every opportunity. The second section explores how history was used to help create and defend the nation, adding to studies of the use of history in nationalist projects. It considers a range of non-professional sites of history-making, demonstrating the complicated relationships between these different sites and the state's wider nationalist agenda. It also explores how history was invoked to justify and defend minority-rule independence both before and after UDI.
22
Yim, Hoi Wing. "The role of C-C chemokine receptor 1 in skeletal muscle regeneration." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86732.
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Diaphragmatic myotubes are known to constitutively express CCR1, a chemokine receptor in the C-C chemokine family, when cultured in vitro. It has been shown that CCR1 and its ligand CCL3 (MIP-1α) are directly involved in muscle repair responses in vitro. Furthermore, in vivo experiments, carried out in the MDX mouse model of muscular dystrophy, showed that these molecules were up-regulated in the dystrophic diaphragm muscle thus suggesting a role for CCR1 in inflammation and muscle healing. In this study, indeed, the role of CCR1 was investigated, with focus on inflammatory cell infiltration within the injured muscle using the freeze injury murine model. This study suggested that there is no significant difference in muscle regeneration or infiltration between CCR1-/- mice and their wild-type controls. There was also no difference in the muscle force between the knockout and their controls at 3, 7, and 14 days post injury. Investigation of individual infiltrating cell (macrophage, CD4 T-cells, CD8 T-cells) populations in the injured tissue yielded no significant difference. These data suggest that, although CCR1 has been found to play a role in myoblast proliferation and migration in vitro, it does not seem to have any apparent effect on muscle regeneration in vivo in the context of the freeze-injury model.<br>In vitro, les myotubes diaphragmatiques expriment de façon constitutive CCR1, le récepteur de la famille des chemokines C-C. Il a été démontré que CCR1 et son ligand, CCL3 (MIP-1α), sont directement impliqués dans le processus de la réparation musculaire in vitro. De plus, des études in vivo dans la souris MDX ont démontré que l'expression de ces molécules augmente dans le diaphragme dystrophique. Ceci suggère un rôle pour CCR1 dans l'inflammation et la réparation musculaire. Dans cette étude, le rôle de CCR1 a été étudié avec un focus sur l'infiltration des cellules dans le muscle blessé suite à une blessure par congélation dans le modèle animal. Cette étude suggère qu'il n'y a aucune différence dans la réparation musculaire et l'infiltration cellulaire entre la souris CCR1 -/- et le contrôle. De plus, il n'y a aucune différence significative dans la force musculaire entre ces deux modèles à 3,7 et 14 jours suite à la blessure. L'étude individuelle des populations cellulaires (macrophages, cellules T CD4+ et CD8+) n'a montré aucune différence significative. Nos résultats suggèrent que malgré le rôle de CCR1 dans la prolifération et la migration de myoblastes in vitro, CCR1 n'est pas implique dans cette régénération post-traumatique in vivo.
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Goldsmith, Alistair Lindsay. "The development of the city of Glasgow police c.1800 - c.1939." Thesis, University of Strathclyde, 2002. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21167.
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Sun, Shangzheng. "Building up molecular complexity by Ni-catalyzed cross-coupling reactions." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670603.
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En línia amb la investigació desenvolupada al nostre grup basada en l’elaboració de noves reaccions d’acoblament
creuat, hem decidit centrar la tesis doctoral en l’estudi de la formació de nous enllaços Csp3–Csp3, utilitzant reaccions
d’acoblament creuat reductores catalitzades per níquel.
Al primer capítol, els nostres esforços es centren en la preparació d’una nova metodologia basada en l’alquilació
reductiva de a-haloboronats, utilitzant com a matèria prima olefines no activades. Aquest nou protocol, quimio- i
regioselectiu, permet l’incorporació d’un fragment alquílic-boronat a olefines no activades, mitjançant condicions de
reacció suaus. Per altra banda, l’ús d’olefines internes permet la formació d’enllaços carboni-carboni en posicions C–H
sp3 llunyanes, a través del procés anomenat “chain-walking” catalitzat per níquel. Al segon capítol, continuant amb el
nostre interès en reaccions catalitzades per níquel, hem estudiat un mètode catalític d’alquilació desaminativa
d’olefines no activades. Aquesta nova metodologia opera sota condicions de reacció suaus i es caracteritza per l’ampli
espectre de compostos que poden acoblar-se selectivament. Aquesta tècnica pot tenir aplicació en el context de la
derivatització de l’etilè i per la funcionalització de molècules d’alt valor afegit.<br>En línea con la investigación desarrollada en nuestro grupo basada en la elaboración de reacciones de
acoplamiento cruzado, hemos decidido centrar la tesis doctoral en el estudio de la formación de enlaces Csp3–Csp3,
usando reacciones de acoplamiento cruzado reductoras catalizadas por níquel.
En el primer capitulo, nuestros esfuerzos se centran en la preparación de una nueva metodología basada en la
alquilación reductiva de a-haloboronatos usando como materia prima olefinas no activadas. Este protocolo, quimio- y
regioselectivo, permite la incorporación de un fragmento alquílico-boronato en olefinas no activadas, y presenta unas
condiciones de reacción suaves. Por otro lado, el uso de olefinas internas permite la formación de enlaces carbonocarbono
en posiciones C-H sp3 lejanas, a través del proceso llamado “chain-walking”, catalizado por níquel. En el
segundo capitulo, siguiendo nuestro interés en reacciones catalizadas por níquel, hemos estudiado un método
catalítico de alquilación desaminativa de olefinas no activadas. Esta nueva metodología opera bajo condiciones de
reacción suaves y se caracteriza por el amplio espectro de compuestos que pueden acoplarse selectivamente. Esta
técnica también puede ser aplicada en el contexto de la derivatización del etileno y para la funcionalización de
moléculas de alto valor añadido.<br>In line with our group research interests on cross-coupling-reactions, we decided to focus this doctoral studies on the
development of sp3 C–C bond formation by means of nickel catalyzed reductive-cross-coupling.
Our first effort was focused on the development of a reductive alkylation of a-haloboronates with unactivated olefin
feedstocks. We have developed a mild, chemo- and site-selective catalytic protocol that allows the incorporation of an
alkylboron fragment into unactivated olefins. Moreover, the use of internal olefins enables C C bond-formation at
remote sp3 C-H sites via nickel catalyzed chain-walking process. Following up our interest on nickel catalyzed chainwalking
events, we reported a site-selective catalytic deaminative alkylation of unactivated olefins. This method
operates under mild conditions and is characterized by a wide substrate scope and exquisite site-selectivity profile.
Particularly noteworthy is that this technique could be employed in the context of ethylene derivatization and for the
late-stage functionalization of complex molecules. Our final efforts for the sp3 C–C bond formation was focused on the
development of a regio-selective cross-coupling of three electrophiles by means of nickel/photoredox dual catalysis.
We developed a modular, chemo- and regio-selective 1,2-difunctionalization of simple vinyl boronates with readily
available organic halides.
25
McAlister, Kirsty F. "James VII and the conduct of Scottish politics c.1679 to c.1686." Thesis, University of Strathclyde, 2003. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21854.
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This thesis provides a detailed examination of the impact of James VII, both as Duke of York and King, on Scottish politics between c. 1679 and c. 1686. This start date has been chosen because, as a result of the Exclusion Crisis in England, Charles II sent his brother and heir, James, Duke of York, to Scotland in November 1679. The thesis ends with a thorough investigation of the final session of James VII's Scottish Parliament, in which his notion of toleration for Roman Catholics was rejected as unpalatable. Between c. 1679 and c. 1686, James had a managerial role over the government of Scotland, not least of all as a result of his prolonged residence in Edinburgh which lasted, with the exception of a seven month period back in England, from November 1679 until March 1682. In the subsequent years James remained closely involved with the government of Scotland largely as a result of the political reshuffle he oversaw immediately prior to his final departure. The themes examined in this thesis include the role of James in relation to a number of significant Scottish political concerns. These include the militia and Highland policies, as well as the enforcement of the 1681 Test Act and pacification of disorder, particularly from the remnant Covenanters. The 1681 Parliament, in which James was High Commissioner, is analysed in detail, as are the1685 and 1686 sessions of the Parliament James held as King. The threat posed by the 1685 Argyll rebellion is also investigated, as is the political factionalism of the period. A substantial amount of primary and secondary sources have been used during the research for this thesis. The primary material includes both printed and manuscript sources, much of which has been previously neglected. This includes contemporary pamphlet literature and correspondence, as well as Supplementary Parliamentary Papers.
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Aglaé, Marie-Joseph. "Fiscalité et intégration dans le C. A. R. I. C. O. M : Caribbean Community an Common Market." Paris 1, 1991. http://www.theses.fr/1991PA010262.
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Une approche comparée des fiscalités internes dans le CARIMON permet de mettre en évidence des différences en matière d'impôt sur les bénéfices des entreprises, et une disparité des techniques d'imposition de la dépense. Elle suggère également d'étendre la coordination des politiques fiscales des pays membres au-delà de l7accord sur l'harmonisation des incitations à l'investissement dans l'industrie. L'appartenance des états de la région à la catégorie des pays en développement les autorise à revendiquer, dans le cadre des conventions fiscales internationales conclues avec les pays exportateurs de capitaux et de connaissances, un large pouvoir d'imposition pour l'état de la source des revenus, afin de sauvegarder leurs intérêts financiers. L'importance des courants d'échanges entre la Caraïbe et les États-Unis d'Amérique impose aux pays du CARICOM de s'attacher à définir une position commune à l'égard de la politique fiscale américaine dans la région. Dans l'ordre communautaire, la convention fiscale entre les pays plus développés d'une part, et les pays moins développés d'autre part, et la mise en place de tels traités au niveau sous-régional doivent tenir compte de la situation des pays les moins avancés économiquement, et favoriser la fluidité des échanges dans le marché commun<br>A comparative approach of inland taxation in CARICOM allows to emphasize the differences as regards tax on profts, and disparition in sales taxes. This approach also suggests the extension of coordination of fiscal policies of member states beyond the agreement on harmonization of fiscal incentives to industry. The states of the region that belong to the category of developing countries, may claim, in the scope of double taxation agreement with capitals and knowledges exporting countries, a large power to tax for the contracting state in wich the incomes are produced. The importance of exchanges between the Caribbean and United States of America induice the CARICOM countries to adopt a common position concerning the American fiscal policy in this region. In the sphere of the community, the double taxation agreement between more developed countries on the one hand less developed countries on the other hand, and the setting up of such treaties at a subregional level must take into account the situation of less developed countries, and favour the flows of exchanges in the common market
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Panichi, Marie-Noëlle. "Caractérisations du spectre tempéré de GLn(C) / GLn(R)." Paris 7, 2001. http://www.theses.fr/2001PA077230.
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Delobel, Bruno. "Evaluation de la p. C. R. Appliquee aux mycobacteries." Lille 2, 1993. http://www.theses.fr/1993LIL2M342.
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Vaughan, Owen. "The r-map, c-map and black hole solutions." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/8953/.
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We consider various geometrical and physical aspects of the r-map and c-map, which are two maps induced by the dimensional reduction of 5d and 4d, N = 2 supergravity coupled to vector multiplets respectively. We treat reduction over a spacelike or timelike dimension on an equal footing, and prove, for the first time, that the target manifold in the image of the timelike c-map is para-quaternion Kahler. In order to do this we provide a new formulation of projective special Kahler geometry based on real Darboux coordinates, which is useful both mathematically and physically in its own right. As an application we investigate how the r-map and c-map can be used to generate new stationary black hole solutions. In four dimensions we construct new extremal non-BPS solutions, and in both four and five dimensions we construct new non-extremal solutions. We also take the first steps towards constructing new rotating solutions, though at this stage we only recover known solutions. The systematic and geometrical nature of these constructions allows us to gain a deeper understanding of many familiar properties of black holes in supergravity, such as the attractor mechanism and the transformation of BPS into non-BPS black holes using a field rotation matrix. We also observe an interesting and novel feature relating to non-extremal black holes: in order for solutions to correspond to non-extremal black holes with finite scalar fields we find that the number of integration constants must reduce by half. This suggests that non-extremal black holes always satisfy first order equations similar to their extremal counterparts. For STU-like models all calculations are performed explicitly.
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Margeta, Milica. "From building a neuron to building a circuit : polarity and synaptic specificity in C. elegans /." May be available electronically:, 2009. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
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Gutiérrez, Bonet Alvaro. "Building up molecular complexity via C-H functionalization and skeletal rearrangements." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/401743.
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L'obtenció de molècules orgànicas complexes a partir de simpl precursors és, avui en dia encara, de gran interès en
el camp de la química sintética. En els darrers anys, la funcionalizació d´enllaços C-H en les molèculas orgàniques i la
no necessitat de prefuncionalizació del productes de partida són els principals avantatges pel gran creixement que ha
experimentat aquesta metodologia. No obstant això, manquen per resoldre aspectes relacionats amb la poca
reactivitat i els problemes associats amb la selectivitat derivats de l´enllaç C-H.
En el treball presentat, s´han desenvolupat dues metodologies on s´utilizen enllaços C-H com a parellas d´acoblament
d´halurs d´aril amb catàlisis de pal.ladi per la construcció de sisteme bicíclics benzofusionats dált valor:
Benzociclobutanones i indans. En el primer cas, un enllaç C(sp2)-H aldehídic és activat per la formació d´anells de 4
membres altament tensionats. En el segon, compostos diazo són combinats amb enllaços C(sp3)-H no activats per a
la síntesis d´estructures tipus indanil amb dos centres quaternaris. Cal remarcar, que per primera vegada s´ha utilizat
un enllaç C(sp3)-H no activat per la síntesis de centres quaternaris.<br>La formación de diversidad estructural a partir the reactivos comunes es de gran importancion en síntesis orgánica.
Durante las últimas décadas, las reacciones de funcionalización C-H han surgido como una excelente alternativa para
tal fin. Entre sus principales ventajas destacan el evitar tener que prefuncionalizar los substratos de partida así como
la ubicuidad de los enlaces C-H. Lamentablemente, su utilización presenta numerosas dificultades como su falta de
reactividad y los problemas de selectividad asociados a su ubicuidad.
Durante el presente trabajo, hemos desarrollado dos metodologías basadas en la utilización de enlaces C-H para la
formación de sistemas cíclicos con un anillo de benceno, concretamente, benzociclobutenonas e indanos. En el caso
de las primeras, hemos llevado a cabo la funcionalización de enlaces aldehídico C(sp2)-H para formar anillos de
cuatro miembros con alta tensión anular. En el segundo caso, diazo compuestos han sido acoplados con enlace C-H
no activados. Cabe destacar que la presente metodología describe la utilización, por vez primera, de enlaces C
(sp3)-H no activados para la síntesis de centros cuaternarios.<br>The construction of molecular complexity from readily available materials is of utmost importance in Organic
Synthesis. In the last decades, C-H functionalization reactions have arosed as an excellent approach to such goal.
The main advantages of C-H functionalization events is the no need of prefunctionalization of the substrate as well as
the ubiquity of the C-H bonds. However, numerous challenges are present as well, such as the poor reactivity of these
bonds and selectivity issues.
During the present work, we have been able to develop two methodologies that employ C-H bonds as coupling partner
with aryl halides under palladium-catalysis for the construction of benzofused bucyclic systems of high added value:
Benzocyclobutenones and indanes. In the first case, an aldehydic C(sp2)-H bond is activated for the synthesis of a
highly strained four-membered ring. For the second, diazo compounds are combined with non-activated C(sp3)-H
bonds for the synthesis of indanyl-cores bearing two quaternary centers.
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Krishnan, Swati [Verfasser], Friedrich C. [Akademischer Betreuer] Simmel, Tim [Gutachter] Liedl, and Friedrich C. [Gutachter] Simmel. "Building Biomimetic Systems using Vesicles and DNA Channels / Swati Krishnan ; Gutachter: Tim Liedl, Friedrich C. Simmel ; Betreuer: Friedrich C. Simmel." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1182536220/34.
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Klimanis, Nils. "Generic programming and algebraic multigrid building blocks for scientific computing." Saarbrücken VDM Verlag Dr. Müller, 2006. http://d-nb.info/989177548/04.
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Ratsch, Friederike [Verfasser]. "Stereo-controlled cleavage of cyclobutanols through Ir-catalyzed C-C bond activation: Mechanistic studies and application in the Total Synthesis of (R,R,R)-alpha-tocopherol / Friederike Ratsch." München : Verlag Dr. Hut, 2020. http://d-nb.info/1219471534/34.
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Wenstad, Peder. "GPS Guided R/C Car : The Local Bug Test Platform." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for teknisk kybernetikk, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-11121.
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This thesis is a part of the Local Hawk student project where the overall goal is to develop a Autonomous Unmanned Aerial Vehicle (AUAV). The project was initiated by Kongsberg Defence Systems (KDS) and is developed in collaboration with the Norwegian University of Science and Technology (NTNU). In an AUAV it is necessary to have a guidance system in order to be autonomous. To be able to test guidance principles in practice without risking the Local Hawk airframe the need of a ground based test platform became apparent. This thesis is the development of the Local Bug Test Platform.The Local Bug is based on a R/C car and utilizes electronics used and developed in the Local Hawk project. In order to understand the system behaviour, vehicle modelling is discussed and two models are presented. One of them is used in a SIMULINK simulator design for the Local Bug. The simulator is used to ensure the correct controller behaviour before it is tested on the real system. Phoenix II is the backbone of the Local Bug electronics and is used to gather measurement data, log data to memory and execute controller algorithms. Custom made C-code is used as a framework providing all the functionality needed. A introduction to Real-Time Workshop is given, and a step-by-step guide on how to use RTW generated C-code on the Phoenix II for controller purposes.A heading controller is designed and used in combination to two different guidance algorithms. The Line of Sight algorithm aims for the next waypoint regardless where the vehicle is positioned relative other waypoints. A Cross-Track Error algorithm with look ahead distance functionality focuses on minimizing the vehicles distance from a desired path. Both algorithms successfully guides the vehicle trough the test route visiting all the waypoints. The Local Bug is now usable as a test platform for controller algorithms. Measurements are logged to memory making it possible to analyse the performance after a test has been conducted. The overall functionality is found to be satisfactory and the Local Hawk project now has its desired controller/guidance test platform.
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Sayada, Chalom. "Interet du typage par p. C. R. De chlamydia trachomatis." Amiens, 1992. http://www.theses.fr/1992AMIEM076.
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Quest, Matthew. "C. L. R. James, direct democracy, and national liberation struggles." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318351.
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Williams, Robert D. "Characterisation of molecular variations in human C-reactive protein." Thesis, Keele University, 2017. http://eprints.keele.ac.uk/3528/.
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The research described here focuses on the molecular variations, clinical significance and structural interactions of the innate immune protein, C-reactive protein (CRP). Monomeric CRP (mCRP) was produced through urea-induced dissociation, at an optimum concentration of 3M urea over a 10-week period. Dissociated samples were purified via size exclusion chromatography and confirmation was provided via Western Blot analysis. In contrast with previous published works, this mCRP retained the ability to reversibly bind to phosphocholine. Furthermore, the binding of mCRP with cell wall polysaccharide does not result in the generic precipitation trend as that seen with pentameric CRP (pCRP). Human serum samples with raised CRP levels ( > 100mg/L) were analysed (n =40) to determine whether circulating mCRP could be detected in vivo. All 40 samples tested positive for pCRP via Western Blot and ELISA analysis, with further quantification via the UV Spectrophotometer supporting the calculated pCRP levels. Monomeric CRP was identified in all the 40 patient samples tested, with an average value recorded of 0.88mg/L (SE = ±0.142). Informed by the results from in vitro mCRP studies, the mCRP displayed a molecular weight of approximately 25kDa based on size exclusion chromatography and Western Blot analysis and demonstrated an ability to reversibly bind phosphocholine. To our knowledge, we are the first to successfully purify and identify a monomeric form of CRP from human serum through these procedures. Crystallisation trials of in vitro produced mCRP and the complex of pCRP with C1qGHR and CWPS did not result in the growth of any protein crystals of sufficient diffraction quality. One crystal from the complex crystallisation trials diffracted to 9Å with follow up conditions currently being pursued. Furthermore, additional crystallisation trials from both experiments have generated potential conditions which may be refined in future research to produce high-quality diffraction grade crystals.
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Cash, Heather. "A Library of Functions in C++ for Building and Manipulating Large Graphs." Honors in the Major Thesis, University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1213.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Engineering and Computer Science<br>Computer Science
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Smith, Angela J. "The life and building activity of Bishop Richard Fox, c. 1448-1528." Thesis, University of London, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367013.
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McAndrew, D. "The catalysts and constraints of castle-building in Suffolk c.1066-1200." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444227/.
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Twenty-seven Suffolk castles were built between 1066 and 1200. This thesis summarises the modern multi-disciplinary surveys of six of them, with the objective of identifying their location, morphology, form and function. The majority of Suffolk castles were built between the late 11th and mid-H-century and reached their largest number during the civil wars cA 135-54. However, a few remained operational after c.1200 and those that did are characterised as either royal or baronial caput castles. Moreover, almost all Suffolk castles were originally earth and timber, whereas the surviving examples were rebuilt in stone before c.1300. Therefore, those castles that survived beyond or were established after c.1200 are unrepresentative. Instead this thesis focuses on the period 1066 to 1200, when the more common sub-baronial, earth and timber Suffolk castles were evidenced. Chapter one identifies the key issues. Chapter two critiques each of the current models in castle studies before rejecting them in favour of a modified Annates model. Chapter three identifies the constraints of the tongue duree, identified as the environmental factors, defined as the climate, topography, geology, hydrology and timber supply in the vicinity of the castle. Chapter four identifies societal constraints, which are sub-divided into structural, social and cultural, and focuses on the Abbey of St Edmund's, its cult, viceroyship, ecclesiastical autonomy and barony, its relationship with the new elite and how it influenced castle building. Chapter five focuses on three of the six surveyed castle earthworks to establish the evenement level of the model, which identifies the castle building agents and the specific historical and political context in which these castles were built. Chapter six brings the different sources and levels of data together to offer a new model, a more nuanced definition of a castle and a comprehensive assessment of the conflicting demands of the catalysts and constraints operating upon the construction of castles in Suffolk. In this it is supported by over two hundred figures and plans, numerous tables, a comprehensive set of appendices and an extensive bibliography.
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Vieira-Martinez, Carolyn E. "Building Kimbundu language community reconsidered in West Central Africa, c. 1500-1750 /." Diss., Restricted to subscribing institutions, 2006. http://proquest.umi.com/pqdweb?did=1280142401&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Newfield, Timothy. "The contours of disease and hunger in Carolingian and early Ottonian Europe (c. 750 - c. 950)." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103644.
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This thesis is the first systematic examination of the textual and material evidence for diseaseand hunger in Carolingian and early Ottonian Europe, c.750 to c.950 CE. It draws upon medieval textual records including annals, capitularies, chronicles, concilia, correspondence, histories, gesta, poetry, polyptychs, secular biographies, and vitae, as well as numerous modern archaeological, palaeobotanical, palaeoclimatic, palaeomicrobiological and palaeopathological reports in order to comment on epidemics, epizootics, food shortages and the baseline or current of non-pestilential disease and chronic hunger underlying them. It first surveys the historical and scientific scholarship on these phenomena and the methodologies intrinsic to their study. The evidence for non-pestilential and chronic hunger is then addressed, before pestilences and food shortages are identified in time and space. We can discern roughly thirty-two peacetime epidemics, ten epizootics, ten famines and twelve lesser shortages. A short investigation of the impact of, and response to, disease and hunger in Carolingian and early Ottonian Europe is presented in conclusion. The thesis demonstrates that disease and hunger, in both endemic and epidemic forms, were common realities for mid eighth- through mid tenth-century continental European populations, and argues that epidemics, epizootics and subsistence crises had major, short-lived but possibly cumulative, repercussions for Carolingian and early Ottonian demographic and, consequently, economic growth, in addition to intensifying the impact of the silent toll of the baseline of non-pestilential disease and chronic hunger. The textual evidence addressed in the thesis is presented in Latin and English in three appendices.<br>Cette thèse est le premier examen systématique des sources textuelles et matérielles concernant la maladie et la faim en Europe carolingienne et ottonienne, entre le milieu du VIIIe et le milieu du Xe siècle. Elle s'appuie sur des sources textuelles, comprenant des annales, capitulaires, chroniques, actes de conciles, la littérature épistolaire, les oeuvres historiques, les gesta, la poésie, les polyptyques, biographies laïques et vies de saints, ainsi que de nombreux rapports archéologiques, paléobotaniques, paléoclimatiques, paléomicrobiologiques et paléopathologiques récents afin d'expliquer les épidémies, épizooties et pénuries alimentaires, de même que le problème fondamental de la faim, qu'elle soit la conséquence de maladies non-pestilentielles ou de maladies chroniques sous-jacentes. Elle passe en revue l'historiographie et l'état des recherches scientifiques sur ces phénomènes ainsi que la méthodologie qui sert à leur étude. Les indications concernant la faim non pestilentielle et chronique sont alors analysées, ensuite celles concernant les pestes et les pénuries alimentaires, qui sont identifiées dans le temps et l'espace. Nous pouvons discerner assez bien trente-deux épidémies en temps de paix, une dizaine d'épizooties, dix famines et dix à douze pénuries moindres. La conclusion présente une enquête bref sur l'impact de la maladie et de la faim et la réponse qu'elles ont suscitées en Europe carolingienne et ottonienne. La thèse démontre que la maladie et la faim, dans ses formes endémique autant qu'épidémique, étaient des réalités courantes pour les populations européennes continentales entre le milieu du VIIIe et le milieu du Xe siècle et défend l'idée selon laquelle les épidémies, les épizooties et les crises de subsistance ont été majeures, de courte durée mais dont l'effet a pu être cumulatif. Leurs répercussions sur la démographie de l'Europe carolingienne et ottonienne et, par conséquent, sur la croissance économique ont intensifié l'impact déjà dévastateur des maladies non pestilentielles et de la faim chronique. Les indications tirées des sources écrites utilisées dans la thèse sont présentées en latin et en traduction anglaise dans trois annexes.
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Whiteway, Eric. "Chemical vapour deposition and raman spectroscopy of large scale C-12 and C-13 graphene monolayers." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114380.
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Chemical vapour deposition on copper is an effective way to synthesize large scale, high quality graphene monolayers. One of the factors limiting the mechanical strength and electronic properties of CVD graphene is the size of crystal domains and the presence of grain boundaries. We investigated the effects of varying growth conditions and found that decreasing methane flow and pressure led to lower graphene nucleation density and larger grain size.Strain engineering presents an opportunity to tune the electronic properties of graphene. We investigated strain in graphene on copper by Raman spectroscopy and found an upshift in the position of the 2D Raman peak with increasing CVD growth temperature. We showed that it is possible to tune the amount of compressive strain in graphene on copper by modifying the CVD growth temperature and that this leads to a shift in Fermi energy and Fermi velocity. We synthesized graphene monolayers comprised of both C-12 and C-13 carbon atoms. Several combination Raman modes were investigated and the D+D′ peak was shown to be the result of an intervalley + intravalley scattering process. Using the isotope dependent shift in Raman spectrum and the presence of strong double resonance partners for several peaks we were able to accurately determine the position of multiple Raman lines. A combination of three different laser energies allowed us to determine the dispersion of these Raman lines and map out an experimental phonon band structure for graphene.<br>La dépôt chimique en phase vapeur (CVD) sur le cuivre est un moyen efficace pour faire la synthèse à grande échelle de monocouches de graphène de haute qualité. L'un des facteurs limitant les propriétés mécaniques et électroniques du graphène CVD est la taille des domaines cristallins et la présence de joints de grains. Nous avons étudié les effets de la variation des conditions de croissance et constaté que la diminution de débit et de pression de méthane mène à une reduction de la densité de nucléation du graphène et à de plus grands grains. L'ingénierie de la tension offre la possibilité d'ajuster les propriétés électroniques du graphène. Nous avons étudié la tension dans le graphène sur cuivre par spectroscopie Raman et constaté un déplacement positif du pic Raman 2D avec l'augmentation de la température de croissance CVD. Nous avons montré qu'il est possible d'ajuster la quantité de compression dans le graphène sur le cuivre en modifiant la température de croissance CVD et que cela mène à un changement dans l'énergie de Fermi et la vitesse de Fermi.Nous avons synthétisé des monocouches de graphène composées d'atomes de carbone C-12 et C-13. Plusieurs modes de combinaison Raman ont été étudiés et nous avons demontré que le pic D + D′ est le résultat d'un processus de diffusion intervallée + intravallée. En exploitant la dépendance du spectre Raman sur l'isotope de carbone et la présence de partenaires de double résonance pour plusieurs pics nous avons pu déterminer avec précision la position de plusieurs lignes Raman. Une combinaison de trois énergies laser différentes nous a permis de déterminer la dispersion de ces lignes Raman et de reconstruire de manière expérimentale une structure de bande de phonon pour le graphène.
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Samy, Luke. "The building society promise : the accessibility, risk and efficiency of building societies in England c.1880-1939." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543612.
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Kubczyk, Tomasz Miroslaw. "Metal-free C-H functionalisation methods." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27485.
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Gaulton, Barry C. "Seventeenth-century stone construction at Ferryland, Newfoundland (area C) /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq25843.pdf.
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Ladas, Ioannis. "The role of phospholipase C enzymes in health and disease." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/75723/.
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Phospholipases C (PLCs) are a large family of enzymes that regulate the cleavage of phosphatidylinositol-4,5- bisphosphate into Inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). This project included research on PLCζ and PLCβ1 on male infertility and thyroid cancer respectively. Human PLCζ (hPLCζ) is the key protein for egg activation following sperm-egg fusion and triggers the release of Ca2+ producing a series of oscillations which initiate embryogenesis. Defects in hPLCζ lead to infertility, thus the project aimed at its expression and enrichment suitable for biomedical applications. The results included 1) Comparison of hPLCζ bacterial expression from twenty four plasmid constructs with varying protein tags. 2) Expression of active soluble hPLCζ, free from its bacterial solubility partners. The PLCβ1 project involved a novel InDel (1076 bp deletion, ATAA junction insertion) identified in the 3rd intron of PLCβ1 (Chr 20) by genome-wide linkage analysis (GWLA, LOD score 3.01) of a large kindred with multinodular goitre (MNG) progressing to papillary thyroid cancer (PTC). Affected individuals exhibited increased PLCβ1 transcript levels in their thyroids and the InDel has a putative ERα binding site. The project aimed to, 1) Develop a genotyping technique for high-throughput PLCβ1 InDel screening in large cohorts 2) Determine the InDel’s mechanism of action in modifying thyrocyte proliferation. 3) Next generation sequencing (NGS) of the chr20 region identified by GWLA to identify potential variants responsible for MNG. 1) A QPCR genotyping method was established and the InDel identified in patients with benign thyroid disease. 2) Reporter gene assays suggested silencer elements within the InDel. 3) PLCβ1 knockdown using siRNA exhibited a trend in inhibiting proliferation of a thyroid cell-line. 4) NGS of the 20cM-Chr20 GWLA identified region found no additional disease loci confirming a role for the PLCβ1 InDel. The InDel provides a biomarker for MNG patients most likely to develop PTC.
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Green, Adrian Gareth. "Houses and households in County Durham and Newcastle c.1570-1730." Thesis, Durham University, 2000. http://etheses.dur.ac.uk/1600/.
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The north east of England witnessed dramatic economic and social change during this period. This study utilises documentary and archaeological sources to investigate the ways in which houses were built and lived in between the late sixteenth and early eighteenth century. Chapter One, `Introduction', addresses the issues associated with architectural change in this period and explains the evidence employed to analyse the social and economic context of housing and relationship of architectural to social change. Chapter Two, `Regionality', defines a region centred on County Durham including Newcastle as the regional capital. Chapter Three: Households in the Hearth Tax 1660-1680, analyses the social stratigraphy of housing mid-way through the study period. Chapter Four: House Survival, establishes the proportion of surviving , houses and questions previous assumptions involved in the analysis of housing change from standing buildings. Chapter Five: Rebuilding Houses, demonstrates the chronology of rebuilding by separate social groups and the ways in which the internal arrangement and external appearance of houses altered between c. 1570 and 1730. Chapter Six: Housing through the Life Cycle, outlines the typical changes in housing through the life cycle, focusing particularly on the relationship between marriage and rebuilding. Chapter Seven: Houses in the eighteenth century Property Market, shows the significance of the commercial exchange of houses from newspaper property advertisements. Chapter Eight: Durham and Newcastle Houses, analyses architectural change and the social topography and turnover in occupancy of housing in the urban centres of the north-east region. Chapter Nine: The Building Process, investigates the mechanisms for architectural change and evaluates the relationship between regional variation and social identity in houses. Chapter Ten: Conclusions, appraises the role of material culture in social process in houses in one corner of early modem England.
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Sellers, Warren William, and w. sellers@paradise net nz. "Picturing currere towards c u r a: Rhizo-imaginary for curriculum." Deakin University. School of Education, 2008. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20081010.054220.
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This critical inquiry in curriculum studies uses poststructuralist and Deleuzian rhizomatic approaches alongside an original 'picturing' methodology. The author genealogically maps historical and contemporary curriculum theorising to deconstruct curriculum 'development' and foreground currere (curriculum reconceptualising). In performing Deleuzian philosophy, his proposed
c u r a reimagines curriculum via currere to envision generatively living-learning