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Rozprawy doktorskie na temat „RAG1 expression”

Autor: Grafiati

Data publikacji: 6 września 2023

Data aktualizacji: 31 lipca 2025

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1

Braga, Aécio Assunção. "Polimorfismos dos genes CD40, ICAM-1, VCAM, E-selectina, LIGHT, RAGE e CX3CR1 relacionados com inflamação e sua associação à obesidade." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-26052015-143307/.

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INTRODUÇÃO: A obesidade é um grave problema de saúde pública, sendo definida como o acúmulo excessivo de gordura, possivelmente decorrente do desequilíbrio, por um longo período, entre a quantidade de energia ingerida e o gasto energético. OBJETIVO: Investigar a contribuição dos polimorfismos dos genes CD40, ICAM-1, VCAM, E-selectina, LIGHT, RAGE e CX3CR1 na associação com a obesidade. CASUÍSTICA E MÉTODOS: O estudo foi realizado no Instituto Dante Pazzanese de Cardiologia (IDPC) e no Hospital Universitário da Universidade de São Paulo (HU/USP), com 199 indivíduos (40 com peso normal, 55 com s

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Lovejoy, Elizabeth A. "RAGE-based strategies for the control of gene expression." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/26699.

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The Cre/loxP site-specific recombinase system evolved within bacteriophage PI as a mechanism to maintain correct unit copy segregation of the prophage within host cells. This thesis reports the application of this system to regulate gene expression in murine cells. To regulate gene expression via RAGE (Recombination Activated Gene Expression) a novel floxed STOP cassette was designed, constructed and tested in murine embryonic fibroblasts (EF) and embryonic stem (ES) cells. When the floxed STOP cassette was used to regulate the expression of the Enhanced Green Fluorescent Protein (EGFP) marker

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Carvalho, Vanessa Isabel Dias Ribeiro de. "C. albicans Cek1 and Ras1: cloning, expression and purification." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/9526.

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Mestrado em Biologia Aplicada - Biologia Molecular e Celular<br>Candida albicans é um fungo polimórfico e patogénico que reside de forma comensal nas superfícies mucosas humanas. Este fungo apresenta um código genético ambíguo, uma vez que, o codão universal leucina CUG é predominantemente traduzido como serina (97%), mas também como leucina (3%). A análise de proteínas de C. albicans que contêm resíduos CUG em importantes posições funcionais, revela que a ambiguidade do codão modela a função da proteína e poderá ter um papel determinante nas vias de sinalização associadas a mudanças mo

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Kim, Sun. "HAPLOINSUFFICIENCY OF RAI1 AND ITS EFFECT ON BDNF EXPRESSION." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/165.

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Smith-Magenis Syndrome (SMS) [OMIM, #182290] is a congenital anomaly and mental retardation (MCA/MR) syndrome associated with deletion of chromosome17p11.2 [1]. The clinical phenotype has been well described and includes minor craniofacial anomalies, self-injurious behaviors as well as sleep disturbances, speech delays, and obesity [1,2,3]. The incidence of SMS is estimated to be ~ 1:15,000 - 25,000 births [2,6]. Among SMS patients, ~90% are comprised of 17p11.2 deletions, while ~10% have RAI1 mutations [8]. All 17p11.2 deletions associated with SMS include RAI1 deletion [10]. RAI1 is thou

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Chen, Suzi Su-Hsin, and suzi chen@med monash edu au. "Cyclooxygenase Expression in Human Diabetes." RMIT University. Medical Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080206.121439.

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Cyclooxygenase (COX) is the rate limiting enzyme that catalyses the production of prostanoids, which are crucial to vascular homeostasis. Evidence suggests that endothelial dysfunction and inflammation play a role in vascular complications in aging and diabetes. Previous animal studies by our laboratory at RMIT University reported enhanced COX expression with aging in rat aortas, platelets and monocytes. Potentially, alteration in COX expression may result in an imbalanced prostanoid production favoring the synthesis of vasoconstrictors and hence increase the risk of cardiovascular events in t

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Sikora, Kristin [Verfasser]. "RAGE-abhängige S100A8- und S100A9-Expression in humanen THP-1 Zellen / Kristin Sikora." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023749920/34.

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Gonçalves, Carolina de Souza. "Expressão de proteínas RAP1 recombinantes e produção de anticorpos anti- RAP1: potencial uso como biomarcador no diagnóstico de tumores." s.n, 2014. https://www.arca.fiocruz.br/handle/icict/9945.

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Di, Candia Leonarda. "The expression and function of RAGE and HMGB1 in airway structural cells in asthma." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32339.

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Asthma is characterised by airway hyperresponsiveness, airflow obstruction, chronic inflammation and airway remodelling, with an increase in airway smooth muscle (ASM) mass and contractility. ASM also releases mediators that support inflammation and remodelling. High-mobility group box 1 (HMGB1) is a nuclear protein that is released by damaged/stressed cells and activated immune cells. HMGB1 signals through pattern recognition receptors (PRRs) including the receptor for advanced glycosylation end products (RAGE) to promote inflammation and tissue repair. HMGB1 binding and function are governed

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Lalk, Michael [Verfasser]. "Tumorregionen-abhängige Expression der Aminosäure-Sensoren MAP4K3, RagC und VPS34 in Glioblastomen / Michael Lalk." Magdeburg : Universitätsbibliothek, 2018. http://d-nb.info/1174626593/34.

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Rösch, Daniela. "Regulation der Expression der Rezeptoren für advanced glycation end products (RAGE) auf humanen Monozyten." [S.l. : s.n.], 2006.

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Gillis, L. Jane. "Expression and recombinase activity of RAG 1 and two splice variants of RAG 2 in mature human primary tonsilar B lymphocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0004/MQ46022.pdf.

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Ferhani, Nassima. "Expression pulmonaire et rôle fonctionnel d'HMGB1 et de son recepteur, RAGE, dans la bronchopneumopathie chronique obstructive." Paris 7, 2010. http://www.theses.fr/2010PA077265.

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La BPCO est une maladie pulmonaire caractérisée par une inflammation et un remodelage tissulaires. HMGBl, une protéine nucléaire libérée durant l'inflammation et la réparation, interagit principalement avec son récepteur, RAGE, constitutivement exprimé dans le poumon. Nous avons montré des taux élevés d'HMGBl dans le lavage bronchoalvéolaire (LBA), la muqueuse et l'épithélium bronchiques, ainsi que dans les macrophages alvéolaires de patients avec BPCO, comparativement à des sujets fumeurs et non-fumeurs. HMGBl dans le LBA corrèle significativement avec le degré de l'obstruction bronchique et

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13

Alexander, Kristen Lena. "Differential Receptors for Advanced Glycation End-Products (RAGE) Expression in Preeclampsia, Intrauterine Growth Restriction and Gestational Diabetes." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5463.

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Preeclampsia (PE), intrauterine growth restriction (IUGR) and gestational diabetes (GDM) increase the risk of maternal and fetal morbidity and mortality. The roles of Advanced Glycation End-products (AGEs) are already well documented concerning inflammation, hypoxia and oxidative stress. AGEs bind to its receptor, Receptor for Advanced Glycation End-products (RAGE), and activate an inflammatory pathway. This pathway alters the efficacy of invasive trophoblast cells and in the placenta and can result in placental dysfunction. We hypothesized that the placental dysfunction found in PE, IUGR, and

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14

Silva, Marcela Claudino da. "Análise da expressão de citocinas e dos receptores RAGE no periodonto de ratos diabéticos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-02062011-150539/.

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As doenças periodontais (DPs) são alterações inflamatórias crônicas que acometem os tecidos de sustentação do órgão dental. A presença do diabetes é refletida em maior severidade e prevalência das DPs tanto em humanos quanto em modelos experimentais. Contudo, os mecanismos biológicos envolvidos no aumento da prevalência e da severidade permanecem pouco conhecidos. Desta forma, o objetivo deste estudo foi avaliar o número de células marcadas por imunohistoquímica para TNF- , IL-1 , IL-6, RANKL, MMP-2, MMP-9 e para os receptores RAGE na doença periodontal experimental decorrente da induçã

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Hausherr, Carolin Kim. "Konditionale Expression von HER-2, H-Ras oder BXB-Raf1 in einem Maustumormodell molekuare [molekulare] Mechanismen der Tumorremission /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975920693.

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Chavez, Matias Elizabeth Murayama. "Expression of Osteoarthritis Biomarkers in Temporomandibular Joints of Mice with and Without Receptor for Advanced Glycation End Products (RAGE)." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/5242.

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This thesis will be organized into three chapters discussing the mechanism underlying the onset and progression of osteoarthritis (OA) in the temporomandibular joint (TMJ). Understanding the mechanism of OA development in the TMJ helps in understanding how OA progresses and how to treat this disease. The goal of this investigation is to examine the process of cartilage degeneration and OA biomarker expression in the TMJ to understand their role in TMJ OA onset and development.Chapter one covers mechanisms that are altered in TMJ OA during disease progression. Using animal models with different

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Ejdesjö, Andreas. "Teratogenic Predisposition in Diabetic Rat Pregnancy." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178175.

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Pre-gestational diabetes increases the risk of congenital malformation in the offspring and both morbidity and mortality in the diabetic mother and her offspring. During pregnancy, high glucose levels act as a teratogen through several cellular and biochemical pathways and increased production of reactive oxygen species (ROS) has a central role in diabetic embryopathy. The aim of this work was to investigate the importance of genetic predisposition for congenital malformations and to study the genes involved in the teratogenic process of diabetic pregnancy. The crossbreeding of two rat strains

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Sawafta, Ashraf. "Design of vector for the expression of shRNA in transgenic animals." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2008. http://tel.archives-ouvertes.fr/tel-00812776.

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Les petits ARN interférents (siRNA) sont encore rarement utilisés chez les vertébrés transgéniques pour inhiber l'expression de gènes. En effet, les vecteurs contenant un promoteur de type ARN polymérase III comme ceux des gènes U6 et H1 qui permettent une expression élevée des gènes codant pour des ARNi dans des cellules sont souvent silencieux in vivo. Dans cette thèse, divers vecteurs exprimant des petits ARN double brins (shRNA) ont été testés dans des cellules en culture et chez des souris transgéniques pour inhiber l'ARN m du gène précoce IE du virus de la pseudo rage porcine responsable

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Maxwell, Morgan. "Rage and social media: The effect of social media on perceptions of racism, stress appraisal, and anger expression among young African American adults." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4311.

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Recently, social media has become a sociopolitical hotbed for discussions of racism. However, no extant studies have questioned if social media use increases how often African Americans vicariously and/or personally experience discrimination in America. The current study sought to answer this question. By examining the relationships between social media use, general stress, race-related stress, and anger expression, and the mediating role of perceived racism, this study explored if frequent social media use influences young African American adults’: a) perceptions of racism, b) experiences wit

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20

Tahiri-Alaoui, Abdessamad. "Modifications cellulaires et moléculaires après infection des racines de Nicotiana par le champignon pathogène Chalara elegans (Nag Rag & Ken. ) : mécanismes de défense et comparaison avec une infection symbiotique." Dijon, 1992. http://www.theses.fr/1992DIJOS035.

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Ce travail a permis de mettre en évidence des mécanismes de défense actifs développés par des Nicotiana vis-à-vis de l'agent de la pourriture noire des racines C. Elegans. Nous avons identifié et localisé cytochimiquement chez C. Elegans des polysaccharides pariétaux pouvant être à l'origine des phénomènes de reconnaissance cellulaire et d'incompatibilité. L'étude ultrastructurale du processus d'infection des racines de l'hôte modérément résistant par C. Elegans a révélé que des modifications pariétales différentielles, selon les couches cellulaires infectées, peuvent conférer à la paroi un ce

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Figueiredo, Anna Carolina Cançado. "Caracterização imunocitoquímica da expressão da proteína RAP1 em blocos de células escamosas provenientes de citologia cervical em meio líquido." s.n, 2015. https://www.arca.fiocruz.br/handle/icict/10915.

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Labrie, Joseph E. III. "Expression of rag2 and V(D)J Recombinase Activity are Reduced in Aged Mice as a Result of Changes in the Bone Marrow Microenvironment: a Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/236.

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Both humans and mice display an age-related decline in immunity. Reduced generation of mature B cells may be a contributing factor due to reduced entry of mature B cells with novel B cell receptors and specificity for pathogens into the mature B cell pool. In aged mice the numbers of B cell precursors within the bone marrow are diminished; there is a severe reduction in numbers of pre-B cells and an increase in numbers of re-circulated mature B cells. Other defects in developing B cells include reduced expression of rag1 and rag2 when measured in total bone marrow precursor populations. In the

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Fantino, Emmanuelle. "Expression transcriptionnelle du gène SRP1 de Saccharomyces cerevisiae : caractérisation d'une séquence intragénique cis-activatrice et implication du facteur général de transcription TUF/RAP1/GRF1." Aix-Marseille 2, 1991. http://www.theses.fr/1991AIX22006.

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Ce memoire decrit un exemple original de regulation de l'expression genique au niveau transcriptionnel, dans la levure saccharomyces cerevisiae. Le gene srp1 est efficacement transcrit et cette transcription est regulee en fonction du substrat et/ou de la phase de croissance. L'utilisation de la technique de retardement de migration a permis de mettre en evidence in vitro une interaction proteine-adn specifique impliquant une region de 33 pb situee en aval du promoteur, dans la region codante du gene srp1, et un facteur proteique specifique et abondant. Le role essentiel de la sequence cible d

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Kanellopoulou, Chrysi. "Analysis of locus accessibility for V(D)J recombination and its potential in generating a mouse model for monitoring RAG protein expression in peripheral B cells." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965433579.

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Gravel, William-Édouard. "Expression de la dystrophine humaine dans le Tibialis anterior de souris Rag/mdx suite à une greffe de cellules myogéniques dérivées d'hiPSCs dystrophiques et corrigées génétiquement." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/26698.

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Les cellules souches embryonnaires humaines (hESCs) et les cellules souches pluripotentes induites humaines (hiPSCs) ont démontré leur capacité d'auto-renouvellement et peuvent potentiellement se différencier en tous les types de lignées cellulaires. Elles représentent donc une source illimitée de cellules pour le développement de thérapies curatives pour les maladies dégénératives, telles que la dystrophie musculaire de Duchenne (DMD). Cette maladie héréditaire est le résultat de diverses mutations dans le gène de la dystrophine. Ces mutations engendrent un changement dans le cadre de lecture

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Degani, G. "MOLECULAR CHARACTERIZATION OF MEMBRANE-BOUND GLYCOPROTEINS INVOLVED IN HUMAN DISEASES AND POTENTIAL TARGETS FOR NEW THERAPIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/274187.

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The present thesis is focused on the molecular characterization of two eukaryotic membrane glycoproteins that are promising candidates for new therapeutic approaches to human diseases. The first glycoprotein is the human Receptor for the Advanced Glycation End products (hRAGE), a member of the immunoglobulin superfamily. RAGE is a type I transmembrane glycoprotein that is beneficial in normal physiological conditions but it is also a key player in the etiology and progression of several chronic pathologies such as neurodegenerative disorders (Alzheimer), atherosclerosis, cancer and complicat

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Rosa, Júnior Nevton Teixeira da. "Determinação da correlação entre as proteínas do complexo shelterin, disquerina, citocinas inflamatórias e comprimento dos telômeros em indivíduos portadores de obesidade." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/157951.

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Nos indivíduos com obesidade, o excesso de tecido adiposo, exerce um papel fundamental induzindo um estado inflamatório crônico e sistêmico. A obesidade mimetiza processos celulares semelhantes aos do envelhecimento tais como a deterioração de tecidos e órgãos e diminuição na capacidade de reparo dos danos induzidos ao DNA. Nesse contexto, as citocinas pró-inflamatórias induzem atritos ao DNA que impactam, principalmente nas regiões mais susceptíveis dos cromossomos, os telômeros. Os telômeros, presentes nas extremidades dos cromossomos, estão associados a um complexo proteico denominado compl

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Muth, Ingrid Elisabeth Verfasser], and Mathias [Akademischer Betreuer] [Bähr. "Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis / Ingrid Elisabeth Muth. Gutachter: Mathias Bähr. Betreuer: Mathias Bähr." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2009. http://d-nb.info/1043027270/34.

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Waern, Johan [Verfasser], and Michael [Akademischer Betreuer] Ott. "Effects of ectopic murine CD47 expression on human hepatocyte engraftment in Rag, gamma c uPA mice / Johan Martin Waern. Klinik für Gastroenterologie, Hepatologie und Endokrinologie der Medizinische Hochschule Hannover. Betreuer: Michael Ott." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2012. http://d-nb.info/1025784057/34.

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Medeiros, Marcell Costa de [UNESP]. "Modulação da proliferação, morte celular e expressão gênica de mediadores inflamatórios pela ativação de RAGE e TLR4 em células da resposta imune inata e adaptativa: papel das vias de sinalização p38 MAPK e NF-kB." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/96192.

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Made available in DSpace on 2014-06-11T19:28:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-03-29Bitstream added on 2014-06-13T19:36:29Z : No. of bitstreams: 1 medeiros_mc_me_arafo.pdf: 437623 bytes, checksum: c85b61f51fbdc5822633362a48f3573b (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O diabetes está associado à maior susceptibilidade à infecções e sepsis, demonstrando uma influência desta condição sobre a resposta imune. A doença periodontal é um tipo de infecção crônica, modulada pela resposta imune que apresenta maior prevalência e severidad

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Medeiros, Marcell Costa de. "Modulação da proliferação, morte celular e expressão gênica de mediadores inflamatórios pela ativação de RAGE e TLR4 em células da resposta imune inata e adaptativa : papel das vias de sinalização p38 MAPK e NF-kB /." Araraquara : [s.n.], 2012. http://hdl.handle.net/11449/96192.

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Orientador: Carlos Rossa Junior<br>Banca: José Eduardo Cezar Sampaio<br>Banca: Adriana Campos Passanezi Sant'Ana<br>Resumo: O diabetes está associado à maior susceptibilidade à infecções e sepsis, demonstrando uma influência desta condição sobre a resposta imune. A doença periodontal é um tipo de infecção crônica, modulada pela resposta imune que apresenta maior prevalência e severidade em pacientes diabéticos. Nosso objetivo foi avaliar um possível sinergismo entre os receptores RAGE e TLR4 na modulação da proliferação celular, atividade metabólica, apoptose e expressão de citocinas inflamató

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Karol, Sven. "Well-Formed and Scalable Invasive Software Composition." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-170162.

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Software components provide essential means to structure and organize software effectively. However, frequently, required component abstractions are not available in a programming language or system, or are not adequately combinable with each other. Invasive software composition (ISC) is a general approach to software composition that unifies component-like abstractions such as templates, aspects and macros. ISC is based on fragment composition, and composes programs and other software artifacts at the level of syntax trees. Therefore, a unifying fragment component model is related to the cont

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Nilavar, Namrata M. "Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5132.

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In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the 3 clinically approved HIV integrase inhibitors (Elvitegravir, Dolutegravir, and Raltegravir) investigated, Elvitegravir can cause harmful effects on long term treatment. In nonlymphoid organ, brain, we observe that RAG1, but not RAG2 is expressed in an age dependent manner. Importantly, RAG1 expression was primarily limited to astrocytes and its expression in neuron appe

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Wang, Ya-Jean, and 王雅貞. "Cloning recombination activating gene 1 and 2 ( rag1 and rag2 ) and analyzing of the genes expression in adaptive immunity ontogenesis of Orange-Spotted Grouper (Epinephelus coioides)." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/38350825233940536103.

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碩士<br>國立成功大學<br>生物學系碩博士班<br>97<br>Orange-spotted grouper (Epinephelus coioides) is a fish species with a high economic importance in the aquaculture industry in Taiwan. The high mortalities observed throughout early development such as viral nervous necrosis (VNN) causes the highest mortalities up to 100% always occur among 1-month-old larvae with total body lengths of 2.0 cm. Teleost is the oldest species has the adaptive immune system. However, there is a risk of inducing immunological tolerance if fish that are immunised at a very early age before they are immunocompetent. Thus, it is impor

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Manyoni, Julian R. "Prophets of rage : expressions of Black nationalism in hip hop." Thesis, 2000. http://hdl.handle.net/2429/10663.

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This paper deals with the development of Black nationalist politics in hip hop, focusing primarily on the years up to 1994. This investigation examines two primary strains of nationalist hip hop which emerged in the late 1980s: Afrocentric hip hop nationalism and pro-Black hip hop nationalism. Afrocentric nationalism is based primarily on the notion of Africa as the root of all Black diasporic culture and the idea that a return (either physically or intellectually) to Africa and it's glorious past is the key to develop the Black nation and confront white racism and oppression. Pro-Black

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FORMICHI, CATERINA. "CEBPb expression pattern regulates RAP1 protein levels in adipose tissue of obese patients and distinguishes subjects with metabolic impairment." Doctoral thesis, 2020. http://hdl.handle.net/11573/1362185.

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The prevalence of obesity and its associated mortality/morbidity has dramatically increased in the last decades, however, factors involved in the development of metabolic complications of obesity are still to be fully elucidated. It has been shown in mouse that a deletion of the telomeric protein RAP1 could have a pathogenic role in obesity and metabolic syndrome (MS). The aim of the present work was to evaluate RAP1 expression in human adipose tissues. RAP1 expression was evaluated in visceral (VAT) and subcutaneous (ScAT) adipose tissue of 49 obese patients and 14 metabolically healthy norma

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Rösch, Daniela [Verfasser]. "Regulation der Expression der Rezeptoren für advanced glycation end products (RAGE) auf humanen Monozyten / vorgelegt von Daniela Rösch." 2005. http://d-nb.info/99540819X/34.

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Wan-Hsuan, Tung, and 董宛璇. "The Role of Rac1/MLK3/JNK/AP-1 in CTGF-Induced Type I Collagen Expression in Lung Fibroblasts." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/53899417254003645945.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>98<br>Several evidences suggest that connective tissue growth factor (CTGF) overproduction underlies the development of lung fibrosis. Development of lung fibrosis is characterized by excessive deposition of collagens in the lung interstitium. Mixed linage kinase 3 (MLK3) can be regulated by Rac and then activate downstream molecule JNK, which in turns activates transcription factor activator protein-1(AP-1). In this study, we found that CTGF could induce collagen expression, and overexpression of wild-type MLK3 also enhanced collagen expression. Overexpressed domina

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Wang, Chun-Chieh, and 王俊傑. "Cloning of rag-1 and Ig gene from cobia, Rachycentron canadum, and their expression during ontogenesis." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/k75y3u.

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碩士<br>國立成功大學<br>生物科技研究所碩博士班<br>90<br>Immunoglobulin produced by B lymphocytes is a major protein involved in the humoral immune response. The variable region of Ig gene is assembled during B lymphocyte development by the recombination of multiple V, D, J segments. This V(D)J rearrangement process generates a vast array of antigen receptors and is strictly mediated by RAG recombinase, encoded by recombination activation gene-1 and -2. Because rag-1 gene, especially in the enzyme-activating core region, is highly conserved among species from teleost to mammals and is critical to the differentiat

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Hagel, Marion [Verfasser]. "Hemmende Wirkung von Östrogenen auf die Rac1-Expression und die Freisetzung von Sauerstoffradikalen in humanen Monozyten / vorgelegt von Marion Hagel." 2008. http://d-nb.info/996205101/34.

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Hausherr, Carolin Kim [Verfasser]. "Konditionale Expression von HER-2, H-Ras oder BXB-Raf1 in einem Maustumormodell : molekuare [molekulare] Mechanismen der Tumorremission / Carolin Kim Hausherr." 2005. http://d-nb.info/975920693/34.

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Faber, Claudius. "Die Expression der Rekombination Aktivierenden Gene (RAG) in Gedächtnis B Zellen von Kindern mit ANA-positiver Juveniler Idiopathischer Arthritis." Doctoral thesis, 2006. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-23099.

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In dieser Arbeit wurden Gedächtnis-B-Zellen von Kindern mit ANA-positiver Juveniler Idiopathischer Arthritis auf die Expression der Rekombination Aktivierenden Gene untersucht<br>We examined memory-B-cells from children with ANA-positive Juvenile Idiopathic Arthritis for the expression of Recombination Activating Genes

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Muth, Ingrid Elisabeth. "Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-AF6D-C.

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Nitti, Maria. "Interfering with Rac1 activity in FRT thyroid epithelial cells impairs the expression of the polarized phenotype and of the E-cadherin function." Tesi di dottorato, 2013. http://www.fedoa.unina.it/9450/1/nitti_maria_25.pdf.

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The acquisition of cell polarity, which includes the establishment of the tight junction barrier, polarized assembly of the cytoskeleton and appropriate organization of membrane traffic, requires external cues, that in epithelial cells are represented by the interaction of cells with their neighbors and with the extracellular matrix. The Rho family of small GTPases, regulate many biological processes including cell cycle progression, apoptosis, migration and intercellular adhesion. We focused on the analysis of the role of Rac1 protein in the acquisition and maintenance of the polarized phenot

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Félix, Daniela Ribeiro Bettencourt. "As GTPases RAC1 e RAC1b na modulação da expressão do simportador de sódio e iodo em tecido tiroideu normal." Master's thesis, 2017. http://hdl.handle.net/10362/26982.

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O simportador de sódio e iodo (NIS) é altamente expresso no tecido da tiróide. Uma vez que a expressão de NIS resulta na acumulação de iodeto, a sua expressão em células tumorais permite o uso de iodo radioativo (131I) no diagnóstico e no tratamento da doença. No entanto, os níveis de expressão de NIS e a absorção de iodo no carcinoma de tiróide são reduzidos quando comparados ao tecido normal. Estudos recentes mostraram que, embora desencadeadas por diferentes vias de sinalização, a estimulação da expressão de NIS envolve a indução da atividade da cinase mitogénica p38 pela GTPase RAC1. O no

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Faber, Claudius [Verfasser]. "Die Expression der Rekombination-aktivierenden Gene (RAG) in Gedächtnis-B-Zellen von Kindern mit ANA-positiver juveniler idiopathischer Arthritis / vorgelegt von Claudius Faber." 2007. http://d-nb.info/984710825/34.

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Weidmann, Rolf Günter [Verfasser]. "Endothel und Regulation der Inflammation : Überexpression inaktiver Mutanten der kleinen GTP-bindenden Proteine RhoA/Rac1/Cdc42 inhibiert die LPS-induzierte Expression von Interleukin-8/CXCL8 in humanen mikrovaskulären Endothelzellen / von Rolf Günter Weidmann." 2005. http://d-nb.info/978803736/34.

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Kanellopoulou, Chrysi [Verfasser]. "Analysis of locus accessibility for V(D)J recombination and its potential in generating a mouse model for monitoring RAG protein expression in peripheral B cells / vorgelegt von Chrysi Kanellopoulou." 2001. http://d-nb.info/965433579/34.

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Karol, Sven. "Well-Formed and Scalable Invasive Software Composition." Doctoral thesis, 2014. https://tud.qucosa.de/id/qucosa%3A28724.

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Software components provide essential means to structure and organize software effectively. However, frequently, required component abstractions are not available in a programming language or system, or are not adequately combinable with each other. Invasive software composition (ISC) is a general approach to software composition that unifies component-like abstractions such as templates, aspects and macros. ISC is based on fragment composition, and composes programs and other software artifacts at the level of syntax trees. Therefore, a unifying fragment component model is related to the cont

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