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1

Ritu, Goswami, Sudha Vengurlekar Dr., and Sachin Kumar Jain Dr. "Comparative Evaluation of Conventional Backscattered Raman Spectroscopy and Transmission Raman Spectroscopy (TRS) for Monitoring Authenticity of APIs in Fixed Dose Combination Drug of Ibuprofen and Paracetamol." Pharmaceutical and Chemical Journal 10, no. 4 (2023): 30–38. https://doi.org/10.5281/zenodo.13995725.

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Raman spectroscopy, one of the most widely used optical spectroscopic technique can provide molecular information about pharmaceutical drugs. This particular spectroscopic technique has proven its potential over the others by overcoming the barriers faced in traditional approaches and by providing unique benefit of molecular characterization in near real time. In this spectroscopy method, incident light interacts with the molecule inelastically and the scattered light has specific vibration modes of molecules in form of sharper Raman peaks. The technique thus can identify the molecular structu
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Petersen, Marlen, Zhilong Yu, and Xiaonan Lu. "Application of Raman Spectroscopic Methods in Food Safety: A Review." Biosensors 11, no. 6 (2021): 187. http://dx.doi.org/10.3390/bios11060187.

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Food detection technologies play a vital role in ensuring food safety in the supply chains. Conventional food detection methods for biological, chemical, and physical contaminants are labor-intensive, expensive, time-consuming, and often alter the food samples. These limitations drive the need of the food industry for developing more practical food detection tools that can detect contaminants of all three classes. Raman spectroscopy can offer widespread food safety assessment in a non-destructive, ease-to-operate, sensitive, and rapid manner. Recent advances of Raman spectroscopic methods furt
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SAKAMOTO, Kenji, and Sukekatsu USHIODA. "Raman Spectroscopy." Hyomen Kagaku 13, no. 2 (1992): 79–87. http://dx.doi.org/10.1380/jsssj.13.79.

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Gerrard, D. L., and J. Birnie. "Raman spectroscopy." Analytical Chemistry 62, no. 12 (1990): 140–50. http://dx.doi.org/10.1021/ac00211a012.

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Gerrard, D. L., and H. J. Bowley. "Raman spectroscopy." Analytical Chemistry 60, no. 12 (1988): 368–77. http://dx.doi.org/10.1021/ac00163a023.

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Mulvaney, Shawn P., and Christine D. Keating. "Raman Spectroscopy." Analytical Chemistry 72, no. 12 (2000): 145–58. http://dx.doi.org/10.1021/a10000155.

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Lyon, L. Andrew, Christine D. Keating, Audrey P. Fox, et al. "Raman Spectroscopy." Analytical Chemistry 70, no. 12 (1998): 341–62. http://dx.doi.org/10.1021/a1980021p.

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Gerrard, D. L., and J. Birnie. "Raman spectroscopy." Analytical Chemistry 64, no. 12 (1992): 502–13. http://dx.doi.org/10.1021/ac00036a026.

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Gerrard, D. L. "Raman Spectroscopy." Analytical Chemistry 66, no. 12 (1994): 547–57. http://dx.doi.org/10.1021/ac00084a020.

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Gerrard, Donald L., and Heather J. Bowley. "Raman spectroscopy." Analytical Chemistry 58, no. 5 (1986): 6–13. http://dx.doi.org/10.1021/ac00296a002.

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Vandenabeele, Peter. "Raman spectroscopy." Analytical and Bioanalytical Chemistry 397, no. 7 (2010): 2629–30. http://dx.doi.org/10.1007/s00216-010-3872-8.

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Williams, Adrian C., and Brian W. Barry. "Raman spectroscopy." Journal of Toxicology: Cutaneous and Ocular Toxicology 20, no. 4 (2001): 497–511. http://dx.doi.org/10.1081/cus-120001872.

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Fenn, Michael B., Petros Xanthopoulos, Georgios Pyrgiotakis, Stephen R. Grobmyer, Panos M. Pardalos, and Larry L. Hench. "Raman Spectroscopy for Clinical Oncology." Advances in Optical Technologies 2011 (October 19, 2011): 1–20. http://dx.doi.org/10.1155/2011/213783.

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Cancer is one of the leading causes of death throughout the world. Advancements in early and improved diagnosis could help prevent a significant number of these deaths. Raman spectroscopy is a vibrational spectroscopic technique which has received considerable attention recently with regards to applications in clinical oncology. Raman spectroscopy has the potential not only to improve diagnosis of cancer but also to advance the treatment of cancer. A number of studies have investigated Raman spectroscopy for its potential to improve diagnosis and treatment of a wide variety of cancers. In this
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14

Kim, Hyung Hun. "Endoscopic Raman Spectroscopy for Molecular Fingerprinting of Gastric Cancer: Principle to Implementation." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/670121.

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Currently, positive endoscopic biopsy is the standard criterion for gastric cancer diagnosis but is invasive, often inconsistent, and delayed although early detection and early treatment is the most important policy. Raman spectroscopy is a spectroscopic technique based on inelastic scattering of monochromatic light. Raman spectrum represents molecular composition of the interrogated volume providing a direct molecular fingerprint. Several investigations revealed that Raman spectroscopy can differentiate normal, dysplastic, and adenocarcinoma gastric tissue with high sensitivity and specificit
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15

Sinha, Rajeev K. "An Inexpensive Raman, Spectroscopy Setup for Raman, Polarized Raman, and Surface Enhanced Raman, Spectroscopy." Instruments and Experimental Techniques 64, no. 6 (2021): 840–47. http://dx.doi.org/10.1134/s002044122106018x.

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Serebrennikova, Kseniya V., Anna N. Berlina, Dmitriy V. Sotnikov, Anatoly V. Zherdev, and Boris B. Dzantiev. "Raman Scattering-Based Biosensing: New Prospects and Opportunities." Biosensors 11, no. 12 (2021): 512. http://dx.doi.org/10.3390/bios11120512.

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The growing interest in the development of new platforms for the application of Raman spectroscopy techniques in biosensor technologies is driven by the potential of these techniques in identifying chemical compounds, as well as structural and functional features of biomolecules. The effect of Raman scattering is a result of inelastic light scattering processes, which lead to the emission of scattered light with a different frequency associated with molecular vibrations of the identified molecule. Spontaneous Raman scattering is usually weak, resulting in complexities with the separation of we
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Yin, Yin, Wu, et al. "Characterization of Coals and Coal Ashes with High Si Content Using Combined Second-Derivative Infrared Spectroscopy and Raman Spectroscopy." Crystals 9, no. 10 (2019): 513. http://dx.doi.org/10.3390/cryst9100513.

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The organic and mineral components in two coals and resulting high-temperature ashes with high silicon content were characterized by second-derivative infrared spectroscopy, Raman spectroscopy, and X-ray diffraction (XRD). The infrared spectra of raw coals show weak organic functional groups bands but strong kaolinite bands because of the relatively high silicates content. In contrast, the Raman spectra of raw coals show strong disordered carbon bands but no mineral bands since Raman spectroscopy is highly sensitive to carbonaceous phases. The overlapping bands of mineral components (e.g., cal
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Agsalda-Garcia, Melissa, Tiffany Shieh, Ryan Souza, et al. "Raman-Enhanced Spectroscopy (RESpect) Probe for Childhood Non-Hodgkin Lymphoma." SciMedicine Journal 2, no. 1 (2020): 1–7. http://dx.doi.org/10.28991/scimedj-2020-0201-1.

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Raman-enhanced spectroscopy (RESpect) probe, which enhances Raman spectroscopy technology through a portable fiber-optic device, characterizes tissues and cells by identifying molecular chemical composition showing distinct differences/similarities for potential tumor markers or diagnosis. In a feasibility study with the ultimate objective to translate the technology to the clinic, a panel of pediatric non-Hodgkin lymphoma tissues and non-malignant specimens had RS analyses compared between standard Raman spectroscopy microscope instrument and RESpect probe. Cryopreserved tissues were mounted
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Frosch, Timea, Andreas Knebl, and Torsten Frosch. "Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy." Nanophotonics 9, no. 1 (2019): 19–37. http://dx.doi.org/10.1515/nanoph-2019-0401.

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AbstractInnovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Rama
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20

Xu, Sai, Xiongmei Huang, and Huazhong Lu. "Advancements and Applications of Raman Spectroscopy in Rapid Quality and Safety Detection of Fruits and Vegetables." Horticulturae 9, no. 7 (2023): 843. http://dx.doi.org/10.3390/horticulturae9070843.

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With the improvement in living standards, consumers have become more aware of healthy diets and pay more attention to the quality and safety of fruits and vegetables. Therefore, it is essential to strengthen the research on rapid detection of the quality and safety of fruits and vegetables. This study mainly outlines five Raman spectroscopy techniques. It introduces their principles and advantages and the current research progress of their application in fruit and vegetable quality and safety detection. Based on the characteristic Raman spectroscopy analysis of different fruits and vegetables,
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21

Luo, Ruihao, Juergen Popp, and Thomas Bocklitz. "Deep Learning for Raman Spectroscopy: A Review." Analytica 3, no. 3 (2022): 287–301. http://dx.doi.org/10.3390/analytica3030020.

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Raman spectroscopy (RS) is a spectroscopic method which indirectly measures the vibrational states within samples. This information on vibrational states can be utilized as spectroscopic fingerprints of the sample, which, subsequently, can be used in a wide range of application scenarios to determine the chemical composition of the sample without altering it, or to predict a sample property, such as the disease state of patients. These two examples are only a small portion of the application scenarios, which range from biomedical diagnostics to material science questions. However, the Raman si
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Kitagawa, Teizo. "Resonance Raman spectroscopy." Journal of Porphyrins and Phthalocyanines 06, no. 04 (2002): 301–2. http://dx.doi.org/10.1142/s1088424602000361.

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The main topics in resonance Raman spectroscopy presented at ICPP-2 in Kyoto are briefly discussed. These include: (i) coherent spectroscopy and low frequency vibrations of ligand-photodissociated heme proteins, (ii) vibrational relaxation revealed by time-resolved anti-Stokes Raman spectroscopy, (iii) electron transfer in porphyrin arrays, (iv) vibrational assignments of tetraazaporphyrins and (v) resonance Raman spectra of an NO storing protein, nitrophorin.
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Shaikh, Rubina, Valeria Tafintseva, Ervin Nippolainen, et al. "Characterisation of Cartilage Damage via Fusing Mid-Infrared, Near-Infrared, and Raman Spectroscopic Data." Journal of Personalized Medicine 13, no. 7 (2023): 1036. http://dx.doi.org/10.3390/jpm13071036.

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Mid-infrared spectroscopy (MIR), near-infrared spectroscopy (NIR), and Raman spectroscopy are all well-established analytical techniques in biomedical applications. Since they provide complementary chemical information, we aimed to determine whether combining them amplifies their strengths and mitigates their weaknesses. This study investigates the feasibility of the fusion of MIR, NIR, and Raman spectroscopic data for characterising articular cartilage integrity. Osteochondral specimens from bovine patellae were subjected to mechanical and enzymatic damage, and then MIR, NIR, and Raman data w
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Jehlička, Jan, Howell G. M. Edwards, and Aharon Oren. "Raman Spectroscopy of Microbial Pigments." Applied and Environmental Microbiology 80, no. 11 (2014): 3286–95. http://dx.doi.org/10.1128/aem.00699-14.

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ABSTRACTRaman spectroscopy is a rapid nondestructive technique providing spectroscopic and structural information on both organic and inorganic molecular compounds. Extensive applications for the method in the characterization of pigments have been found. Due to the high sensitivity of Raman spectroscopy for the detection of chlorophylls, carotenoids, scytonemin, and a range of other pigments found in the microbial world, it is an excellent technique to monitor the presence of such pigments, both in pure cultures and in environmental samples. Miniaturized portable handheld instruments are avai
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Carpentier, Philippe, Antoine Royant, Jérémy Ohana, and Dominique Bourgeois. "Advances in spectroscopic methods for biological crystals. 2. Raman spectroscopy." Journal of Applied Crystallography 40, no. 6 (2007): 1113–22. http://dx.doi.org/10.1107/s0021889807044202.

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A Raman microspectrophotometer is described that allows the spectroscopic investigation of protein crystals under exactly the same conditions as those used for X-ray data collection. The concept is based on the integration of the Raman excitation/collection optics into a microspectrophotometer built around a single-axis diffractometer and a cooling device. It is shown that Raman spectra of outstanding quality can be recorded from crystallized macromolecules under non-resonant conditions. It is proposed that equipment developed in the context of macromolecular cryocrystallography, such as commo
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TAKAYANAGI, Masao, and Hiromi OKAMOTO. "Nonlinear Raman Spectroscopy." Journal of the Spectroscopical Society of Japan 46, no. 3 (1997): 131–45. http://dx.doi.org/10.5111/bunkou.46.131.

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TASUMI, MITSUO. "Laser Raman spectroscopy." Review of Laser Engineering 21, no. 1 (1993): 208–11. http://dx.doi.org/10.2184/lsj.21.208.

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Grausem, J., B. Humbert, A. Burneau, and J. Oswalt. "Subwavelength Raman spectroscopy." Applied Physics Letters 70, no. 13 (1997): 1671–73. http://dx.doi.org/10.1063/1.118665.

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Kobayashi, Masamichi. "Laser raman spectroscopy." Kobunshi 40, no. 5 (1991): 338–41. http://dx.doi.org/10.1295/kobunshi.40.338.

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Campion, Alan, and W. H. Woodruff. "Multichannel Raman spectroscopy." Analytical Chemistry 59, no. 22 (1987): 1299A—1308A. http://dx.doi.org/10.1021/ac00149a001.

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Widmann, John F., Christopher L. Aardahl, and E. James Davis. "Microparticle Raman spectroscopy." TrAC Trends in Analytical Chemistry 17, no. 6 (1998): 339–45. http://dx.doi.org/10.1016/s0165-9936(98)00038-7.

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Brusatori, Michelle, Gregory Auner, Thomas Noh, Lisa Scarpace, Brandy Broadbent, and Steven N. Kalkanis. "Intraoperative Raman Spectroscopy." Neurosurgery Clinics of North America 28, no. 4 (2017): 633–52. http://dx.doi.org/10.1016/j.nec.2017.05.014.

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Basilio, Fernando C., Patricia T. Campana, Eralci M. Therézio, et al. "Ellipsometric Raman Spectroscopy." Journal of Physical Chemistry C 120, no. 43 (2016): 25101–9. http://dx.doi.org/10.1021/acs.jpcc.6b08809.

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Hazle, M. A., M. Mehicic, D. J. Gardiner, and P. R. Graves. "Practical Raman Spectroscopy." Vibrational Spectroscopy 1, no. 1 (1990): 104. http://dx.doi.org/10.1016/0924-2031(90)80015-v.

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Durig, J. R. "Practical Raman Spectroscopy." TrAC Trends in Analytical Chemistry 9, no. 10 (1990): IX. http://dx.doi.org/10.1016/0165-9936(90)85071-e.

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Waters, D. N. "Laboratory Raman spectroscopy." Endeavour 9, no. 4 (1985): 207. http://dx.doi.org/10.1016/0160-9327(85)90093-6.

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Ohtsuka, Toshiaki. "Laser Raman Spectroscopy." Zairyo-to-Kankyo 42, no. 9 (1993): 592–600. http://dx.doi.org/10.3323/jcorr1991.42.592.

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DePaola, B. D., S. S. Wagal, and C. B. Collins. "Nuclear Raman spectroscopy." Journal of the Optical Society of America B 2, no. 4 (1985): 541. http://dx.doi.org/10.1364/josab.2.000541.

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Robert, Bruno. "Resonance Raman spectroscopy." Photosynthesis Research 101, no. 2-3 (2009): 147–55. http://dx.doi.org/10.1007/s11120-009-9440-4.

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Ziegler, L. D. "Hyper-Raman spectroscopy." Journal of Raman Spectroscopy 21, no. 12 (1990): 769–79. http://dx.doi.org/10.1002/jrs.1250211203.

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Beattie, ProfessorI. "Laser Raman spectroscopy." Spectrochimica Acta Part A: Molecular Spectroscopy 44, no. 10 (1988): 1063. http://dx.doi.org/10.1016/0584-8539(88)80229-0.

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Priyanshi, Pandey, Vengurlekar Sudha, and Kumar Jain Sachin. "Raman Spectroscopy: A Review." Pharmaceutical and Chemical Journal 10, no. 2 (2023): 43–48. https://doi.org/10.5281/zenodo.13983760.

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This article reviews recent advances in Raman spectroscopy its types and its applications, from the perspective of pharmaceutical analysis. The emerging concepts enable rapid non-invasive analysis of pharmaceutical formulations and could lead to many important applications in pharmaceutical settings, including quantitative bulk analysis of intact pharmaceutical tablets in quality and process control. Raman spectroscopy is particularly useful as a screening tool for quick evaluation of chemicals and pharmaceuticals since it is simple, non- destructive and information-rich.
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Pchelkina, V. A., I. M. Chernukha, L. V. Fedulova, and N. A. Ilyin. "Raman spectroscopic techniques for meat analysis: A review." Theory and practice of meat processing 7, no. 2 (2022): 97–111. http://dx.doi.org/10.21323/2414-438x-2022-7-2-97-111.

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Raman spectroscopy (vibrational spectroscopy) proved to be an effective analytical approach in the field of geology, semiconductors, materials and polymers. Over the past decade, Raman spectroscopy has attracted the attention of researchers as a non-destructive, highly sensitive, fast and eco-friendly method and has demonstrated the unique capabilities of food analysis. The use of Raman spectroscopic methods (RSMs) to assess the quality of meat and finished products is rapidly expanding. From the analysis of one sample, you can get a large amount of information about the structure of proteins,
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Laskowska, Paulina, Piotr Mrowka, and Eliza Glodkowska-Mrowka. "Raman Spectroscopy as a Research and Diagnostic Tool in Clinical Hematology and Hematooncology." International Journal of Molecular Sciences 25, no. 6 (2024): 3376. http://dx.doi.org/10.3390/ijms25063376.

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Raman spectroscopy is a molecular spectroscopic technique able to provide detailed information about the chemical structure, phase, crystallinity, and molecular interactions of virtually any analyzed sample. Although its medical applications have been studied for several decades, only recent advances in microscopy, lasers, detectors, and better understanding of the principles of the Raman effect have successfully expanded its applicability to clinical settings. The promise of a rapid, label-free diagnostic method able to evaluate the metabolic status of a cell in vivo makes Raman spectroscopy
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Varghese, Sanoj, Ambili Reveendran, V. senthil Kumar, Karthikeyan Tm, and Venkiteshan Ranganathan. "MICRO RAMAN SPECTROSCOPIC ANALYSIS ON BLOOD SERUM SAMPLES OF DUCTAL CARCINOMA PATIENTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 176. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.26806.

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Objective: Identification of biochemical changes in ductal cancer patient’s serum samples using micro Raman spectroscopy.Methods: Micro Raman spectroscopy was used for the identification of Raman shift bands. Data analysis was done using K-means clustering.Results: Micro Raman spectroscopic analysis of human breast cancer patient’s serum samples was done. Biochemicals present in the samples were identified from the peak evaluations. K-means clustering analysis was used to differentiate the biochemicals present in the samples.Conclusion: From the study, we conclude that Raman spectroscopy has t
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Joshi, Rahul, Ritu Joshi, Changyeun Mo, et al. "Raman Spectral Analysis for Quality Determination of Grignard Reagent." Applied Sciences 10, no. 10 (2020): 3545. http://dx.doi.org/10.3390/app10103545.

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Grignard reagent is one of the most popular materials in chemical and pharmaceutical reaction processes, and requires high quality with minimal adulteration. In this study, Raman spectroscopic technique was investigated for the rapid determination of toluene content, which is one of the common adulterants in Grignard reagent. Raman spectroscopy is the most suitable spectroscopic method to mitigate moisture and CO2 interference in the molecules of Grignard reagent. Raman spectra for the mixtures of toluene and Grignard reagent with different concentrations were analyzed with a partial least squ
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Goldrick, Stephen, David Lovett, Gary Montague, and Barry Lennox. "Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process." Bioengineering 5, no. 4 (2018): 79. http://dx.doi.org/10.3390/bioengineering5040079.

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Raman spectroscopy is a novel tool used in the on-line monitoring and control of bioprocesses, offering both quantitative and qualitative determination of key process variables through spectroscopic analysis. However, the wide-spread application of Raman spectroscopy analysers to industrial fermentation processes has been hindered by problems related to the high background fluorescence signal associated with the analysis of biological samples. To address this issue, we investigated the influence of fluorescence on the spectra collected from two Raman spectroscopic devices with different wavele
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Frost, Ray L., and Matt Weier. "Raman and infrared spectroscopy of tsumcorite mineral group." Neues Jahrbuch für Mineralogie - Monatshefte 2004, no. 7 (2004): 317–36. http://dx.doi.org/10.1127/0028-3649/2004/2004-0317.

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Williams, K. P. J., and I. C. Wilcock. "Raman Spectroscopy of Polymers*." Engineering Plastics 5, no. 6 (1997): 147823919700500. http://dx.doi.org/10.1177/147823919700500605.

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Raman spectroscopy as a routine analytical method is now coming of age. Advances in Raman technology have meant that robust, user-friendly equipment can be manufactured at a reasonable cost. This article describes these advances as well as providing applications of Raman imaging microscope systems to polymer analysis.
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Williams, K. P. J., and I. C. Wilcock. "Raman Spectroscopy of Polymers*." Polymers and Polymer Composites 5, no. 6 (1997): 443–49. http://dx.doi.org/10.1177/096739119700500605.

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Raman spectroscopy as a routine analytical method is now coming of age. Advances in Raman technology have meant that robust, user-friendly equipment can be manufactured at a reasonable cost. This article describes these advances as well as providing applications of Raman imaging microscope systems to polymer analysis.
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