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Artykuły w czasopismach na temat „Recombinant Salmonella vaccine”

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1

Kraehenbuhl, J. P., I. Corthésy-Theulaz, and D. Nardelli-Haefliger. "Recombinant Salmonella as vaccine carriers." Research in Immunology 149, no. 1 (January 1998): 87–90. http://dx.doi.org/10.1016/s0923-2494(98)80054-0.

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Bradley, Mark P., Lyn A. Hinds, and Peter H. Bird. "A bait-delivered immunocontraceptive vaccine for the European red fox (Vulpes vulpes) by the year 2002?" Reproduction, Fertility and Development 9, no. 1 (1997): 111. http://dx.doi.org/10.1071/r96066.

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An orally-delivered immunocontraceptive vaccine is being developed for the control of fox populations. A number of genes (PH-20, LDH-C4, ZP3) encoding gamete proteins have been cloned, produced in recombinant expression systems and used in fertility trials to test the efficacy of these antigens. As the immunocontraceptive vaccine will be delivered in a bait, there is a requirement for a greater understanding of the immune responses of the reproductive mucosa in canids, and the assessment of the best vaccine delivery system that will evoke a mucosal antibody response. Several vaccine delivery s

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3

Husseiny, Mohamed I., and Michael Hensel. "Rapid Method for the Construction of Salmonella enterica Serovar Typhimurium Vaccine Carrier Strains." Infection and Immunity 73, no. 3 (March 2005): 1598–605. http://dx.doi.org/10.1128/iai.73.3.1598-1605.2005.

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ABSTRACT Salmonella enterica serovar Typhimurium is a versatile organism for the generation of live recombinant vaccines for mucosal immunization. Various strategies have been devised for the stable and efficient expression of heterologous antigens by attenuated S. enterica strains, but these methods often require complex manipulations. Use of phage λ Red recombinase has recently been devised for gene replacements in Escherichia coli and S. enterica after introduction of PCR products. Based on this method, we have developed an approach that allows the integration of recombinant expression cass

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4

Potera, Carol. "Phosphatase Makes Recombinant Salmonella Vaccine Vectors Safer." Microbe Magazine 6, no. 11 (January 1, 2011): 471–72. http://dx.doi.org/10.1128/microbe.6.471.1.

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Kang, Ho Young, Jay Srinivasan, and Roy Curtiss. "Immune Responses to Recombinant Pneumococcal PspA Antigen Delivered by Live Attenuated Salmonella enterica Serovar Typhimurium Vaccine." Infection and Immunity 70, no. 4 (April 2002): 1739–49. http://dx.doi.org/10.1128/iai.70.4.1739-1749.2002.

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ABSTRACT Attenuated Salmonella enterica serovar Typhimurium expressing recombinant antigens from other pathogens elicits primarily a Th1-type dominant immune response to both recombinant and Salmonella antigens. The immunogenicity and appropriate subcellular location of the recombinant antigen in the Salmonella vaccine strain may contribute to augmenting immune responses by facilitating adequate exposure of recombinant antigen to antigen-presenting cells for processing. To allow for secretion from gram-negative bacteria and overexpression of antigen, a DNA fragment encoding a highly antigenic

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6

Su, Huali, Qing Liu, Xiaoping Bian, Shifeng Wang, Roy Curtiss, and Qingke Kong. "Synthesis and delivery of Streptococcus pneumoniae capsular polysaccharides by recombinant attenuated Salmonella vaccines." Proceedings of the National Academy of Sciences 118, no. 2 (December 30, 2020): e2013350118. http://dx.doi.org/10.1073/pnas.2013350118.

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Streptococcus pneumoniae capsular polysaccharides (CPSs) are major determinants of bacterial pathogenicity. CPSs of different serotypes form the main components of the pneumococcal vaccines Pneumovax, Prevnar7, and Prevnar13, which substantially reduced the S. pneumoniae disease burden in developed countries. However, the laborious production processes of traditional polysaccharide-based vaccines have raised the cost of the vaccines and limited their impact in developing countries. The aim of this study is to develop a kind of low-cost live vaccine based on using the recombinant attenuated Sal

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7

Gunn, Bronwyn M., Soo-Young Wanda, Dana Burshell, Caihong Wang, and Roy Curtiss. "Construction of Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Vector Strains for Safety in Newborn and Infant Mice." Clinical and Vaccine Immunology 17, no. 3 (March 2010): 354–62. http://dx.doi.org/10.1128/cvi.00412-09.

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ABSTRACT Recombinant bacterial vaccines must be safe, efficacious, and well tolerated, especially when administered to newborns and infants to prevent diseases of early childhood. Many means of attenuation have been shown to render vaccine strains susceptible to host defenses or unable to colonize lymphoid tissue effectively, thus decreasing their immunogenicity. We have constructed recombinant attenuated Salmonella vaccine strains that display high levels of attenuation while retaining the ability to induce high levels of immunogenicity and are well tolerated in high doses when administered t

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8

Cao, Y., Z. Wen, and D. Lu. "Construction of a recombinant oral vaccine against Salmonella typhi and Salmonella typhimurium." Infection and Immunity 60, no. 7 (1992): 2823–27. http://dx.doi.org/10.1128/iai.60.7.2823-2827.1992.

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9

Curtiss III, Roy, Wei Xin, Yuhua Li, Wei Kong, Soo-Young Wanda, Bronwyn Gunn, and Shifeng Wang. "New Technologies in Using Recombinant Attenuated Salmonella Vaccine Vectors." Critical Reviews™ in Immunology 30, no. 3 (2010): 255–70. http://dx.doi.org/10.1615/critrevimmunol.v30.i3.30.

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10

Wang, Shifeng, Qingke Kong, and Roy Curtiss. "New technologies in developing recombinant attenuated Salmonella vaccine vectors." Microbial Pathogenesis 58 (May 2013): 17–28. http://dx.doi.org/10.1016/j.micpath.2012.10.006.

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11

Xu, Xin, Mohamed I. Husseiny, Andreas Goldwich, and Michael Hensel. "Efficacy of Intracellular Activated Promoters for Generation of Salmonella-Based Vaccines." Infection and Immunity 78, no. 11 (August 23, 2010): 4828–38. http://dx.doi.org/10.1128/iai.00298-10.

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ABSTRACT Salmonella enterica is a versatile vaccine carrier for heterologous antigens. One strategy for vaccine antigen delivery is the use of live attenuated S. enterica strains that translocate heterologous antigens into antigen-presenting cells by means of type III secretion systems (T3SS). The feasibility of this approach has been demonstrated in various experimental vaccination studies. The efficacy of recombinant live vaccines is critically influenced by the optimal level of attenuation and many other factors. For the rational design of approaches involving translocation by T3SS, additio

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12

Benitez, Alvaro J., Nina McNair, and Jan R. Mead. "Oral Immunization with Attenuated Salmonella enterica Serovar Typhimurium Encoding Cryptosporidium parvum Cp23 and Cp40 Antigens Induces a Specific Immune Response in Mice." Clinical and Vaccine Immunology 16, no. 9 (July 15, 2009): 1272–78. http://dx.doi.org/10.1128/cvi.00089-09.

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ABSTRACT Attenuated Salmonella enterica serovar Typhimurium vaccine strain SL3261 was used as an antigen delivery system for the oral immunization of mice against two Cryptosporidium parvum antigens, Cp23 and Cp40. Each antigen was subcloned into the pTECH1 vector system, which allows them to be expressed as fusion proteins with highly immunogenic fragment C of tetanus toxin under the control of the anaerobically inducible nirB promoter. The recombinant vector was introduced into Salmonella Typhimurium vaccine strain SL3261, and the stable soluble expression of the chimeric protein was evaluat

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13

Kang, Xilong, Yun Yang, Yang Jiao, Hongqin Song, Li Song, Dan Xiong, Lili Wu, Zhiming Pan, and Xinan Jiao. "HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus in Mice." Journal of Molecular Microbiology and Biotechnology 26, no. 6 (2016): 422–32. http://dx.doi.org/10.1159/000448895.

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In 2009, a novel pandemic swine-origin influenza A (H1N1) virus caused a public emergency of international concern. Vaccination is the primary strategy for the control of influenza epidemics. However, the poor immunopotency of many vaccine antigens is a major barrier to the development of effective vaccines against influenza. Flagellin, a Toll-like receptor 5 (TLR5) ligand, has been used as an adjuvant to enhance the immunopotency of vaccines in preclinical studies. Here, we developed a recombinant candidate vaccine, HA1-2-fljB, in which the globular head of the hemagglutinin (HA) antigen (res

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14

Baud, David, Jalil Benyacoub, Véronique Revaz, Menno Kok, Françoise Ponci, Martine Bobst, Roy Curtiss, Pierre De Grandi, and Denise Nardelli-Haefliger. "Immunogenicity against Human Papillomavirus Type 16 Virus-Like Particles Is Strongly Enhanced by the PhoPc Phenotype in Salmonella enterica Serovar Typhimurium." Infection and Immunity 72, no. 2 (February 2004): 750–56. http://dx.doi.org/10.1128/iai.72.2.750-756.2004.

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ABSTRACT Recombinant Salmonella strains have been widely used to deliver heterologous antigens and induce immune responses in vaccinated animals and humans. It remains to be established, however, how these bacteria mount an immune response; this has prevented the rational design of vaccines. Here we report for the first time that a particular genetic program, PhoPc, is necessary for recombinant Salmonella strains to induce an antibody response to a heterologous antigen, the human papillomaviruses type 16 (HPV16) virus-like particle (VLP). The PhoPc phenotype results from a point mutation in ph

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15

Guillobel, Heloisa C. R., Joana I. Carinhanha, Lucia Cárdenas, John D. Clements, Darcy F. de Almeida, and Luís C. S. Ferreira. "Adjuvant Activity of a Nontoxic Mutant of Escherichia coli Heat-Labile Enterotoxin on Systemic and Mucosal Immune Responses Elicited against a Heterologous Antigen Carried by a LiveSalmonella enterica Serovar Typhimurium Vaccine Strain." Infection and Immunity 68, no. 7 (July 1, 2000): 4349–53. http://dx.doi.org/10.1128/iai.68.7.4349-4353.2000.

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ABSTRACT Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenicEscherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT(R192G). The results further support the adjuvant effects of LT(R192G) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccin

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16

Luo, Fengling, Yong Feng, Min Liu, Pingfei Li, Qin Pan, Victor Tunje Jeza, Bing Xia, Jianguo Wu, and Xiao-Lian Zhang. "Type IVB Pilus Operon Promoter Controlling Expression of the Severe Acute Respiratory Syndrome-Associated Coronavirus Nucleocapsid Gene in Salmonella enterica Serovar Typhi Elicits Full Immune Response by Intranasal Vaccination." Clinical and Vaccine Immunology 14, no. 8 (June 27, 2007): 990–97. http://dx.doi.org/10.1128/cvi.00076-07.

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ABSTRACT Attenuated Salmonella enterica serovar Typhi strains have been considered to be attractive as potential live oral delivery vector vaccines because of their ability to elicit the full array of immune responses in humans. In this study, we constructed an attenuated S. enterica serovar Typhi strain stably expressing conserved nucleocapsid (N) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) by integrating the N gene into the pilV gene, which was under the control of the type IVB pilus operon promoter in S. enterica serovar Typhi. BALB/c mice were immunized w

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17

Kohler, James J., Latha Pathangey, Adnan Hasona, Ann Progulske-Fox, and Thomas A. Brown. "Long-Term Immunological Memory Induced by Recombinant Oral Salmonella Vaccine Vectors." Infection and Immunity 68, no. 7 (July 1, 2000): 4370–73. http://dx.doi.org/10.1128/iai.68.7.4370-4373.2000.

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ABSTRACT We have previously shown that Salmonella entericaserovar Typhimurium expressing the hagB hemagglutinin gene from Porphyromonas gingivalis can induce primary and recall immune responses in serum and secretions in mice; however, the longevity of memory induced by oral Salmonella carriers has not been adequately demonstrated. In this study, we examined the capacity of mice to mount a recall response 52 weeks after primary immunization. Recall responses were seen in serum immunoglobulin G (IgG) and IgA following boosting at week 52, and in most cases, they were equal to or greater than th

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18

Sbrogio-Almeida, M. E., T. Mosca, L. M. Massis, I. A. Abrahamsohn, and L. C. S. Ferreira. "Host and Bacterial Factors Affecting Induction of Immune Responses to Flagellin Expressed by Attenuated Salmonella Vaccine Strains." Infection and Immunity 72, no. 5 (May 2004): 2546–55. http://dx.doi.org/10.1128/iai.72.5.2546-2555.2004.

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ABSTRACT Previous observations demonstrated that the delivery of recombinant Salmonella enterica serovar Dublin strains to mice via mucosal routes did not efficiently activate systemic and secreted antibody responses to either type d flagellin or genetically fused heterologous B-cell epitopes, thus reducing the usefulness of the protein as a carrier of epitopes for vaccine purposes. In this work, we investigated murine systemic and mucosal flagellin immunogenicity after oral immunization with attenuated Salmonella strains. The reduced anti-type d flagellin antibody responses in mice immunized

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19

Schnapp, Anita R., Chris S. Eickhoff, Donata Sizemore, Roy Curtiss, and Daniel F. Hoft. "Cruzipain Induces Both Mucosal and Systemic Protection against Trypanosoma cruzi in Mice." Infection and Immunity 70, no. 9 (September 2002): 5065–74. http://dx.doi.org/10.1128/iai.70.9.5065-5074.2002.

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ABSTRACT Cruzipain, the major cysteinyl proteinase of Trypanosoma cruzi, is expressed by all developmental forms and strains of the parasite and stimulates potent humoral and cellular immune responses during infection in both humans and mice. This information suggested that cruzipain could be used to develop an effective T. cruzi vaccine. To study whether cruzipain-specific T cells could inhibit T. cruzi intracellular replication, we generated cruzipain-reactive CD4+ Th1 cell lines. These T cells produced large amounts of gamma interferon when cocultured with infected macrophages, resulting in

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20

Baud, David, Françoise Ponci, Martine Bobst, Pierre De Grandi, and Denise Nardelli-Haefliger. "Improved Efficiency of a Salmonella-Based Vaccine against Human Papillomavirus Type 16 Virus-Like Particles Achieved by Using a Codon-Optimized Version of L1." Journal of Virology 78, no. 23 (December 1, 2004): 12901–9. http://dx.doi.org/10.1128/jvi.78.23.12901-12909.2004.

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ABSTRACT Cervical cancer results from cervical infection by human papillomaviruses (HPVs), especially HPV16. An effective vaccine against these HPVs is expected to have a dramatic impact on the incidence of this cancer and its precursor lesions. The leading candidate, a subunit prophylactic HPV virus-like particle (VLP) vaccine, can protect women from HPV infection. An alternative improved vaccine that avoids parenteral injection, that is efficient with a single dose, and that induces mucosal immunity might greatly facilitate vaccine implementation in different settings. In this study, we have

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Leal, Monica Teixeira Andrade, Ariane Guglielmi Ariza Camacho, Laís Helena Teixeira, Daniel Youssef Bargieri, Irene Silva Soares, Cibele Aparecida Tararam, and Mauricio M. Rodrigues. "Immunogenicity of Recombinant Proteins Consisting of Plasmodium vivax Circumsporozoite Protein Allelic Variant-Derived Epitopes Fused with Salmonella enterica Serovar Typhimurium Flagellin." Clinical and Vaccine Immunology 20, no. 9 (July 17, 2013): 1418–25. http://dx.doi.org/10.1128/cvi.00312-13.

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ABSTRACTAPlasmodium falciparumcircumsporozoite protein (CSP)-based recombinant fusion vaccine is the first malaria vaccine to reach phase III clinical trials. Resistance to infection correlated with the production of antibodies to the immunodominant central repeat region of the CSP. In contrast toP. falciparum, vaccine development against the CSP ofPlasmodium vivaxmalaria is far behind. Based on this gap in our knowledge, we generated a recombinant chimeric protein containing the immunodominant central repeat regions of theP. vivaxCSP fused toSalmonella entericaserovar Typhimurium-derived flag

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Popova, P. Yu, and N. I. Mikshis. "PERSPECTIVES OF DEVELOPMENT OF LIVE RECOMBINANT ANTHRAX VACCINES BASED ON OPPORTUNISTIC AND APATHOGENIC MICROORGANISMS." Journal of microbiology epidemiology immunobiology, no. 1 (February 28, 2016): 79–89. http://dx.doi.org/10.36233/0372-9311-2016-1-79-89.

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Live genetic engineering anthrax vaccines on the platform of avirulent and probiotic micro-ogranisms are a safe and adequate alternative to preparations based on attenuated Bacillus anthracis strains. Mucosal application results in a direct contact of the vaccine preparations with mucous membranes in those organs and tissues of the macro-organisms, that are exposed to the pathogen in the first place, resulting in a development of local and systemic immune response. Live recombinant anthrax vaccines could be used both separately as well as in a prime-boost immunization scheme. The review focuse

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Nurjayadi, Muktiningsih, Izzatul Ilma Chairinnisa, Geta Putri Mentari, Dudi Hardianto, Asri Sulfianti, and Kurnia Agustini. "Pengaruh Jumlah Inokulum Sel Inang Bakteri E.coli BL21 (DE3) pLysS dan Waktu Overekspresi pada Produksi Protein Rekombinan Fim-C Salmonella typhi." Jurnal Kimia VALENSI 4, no. 2 (November 30, 2018): 98–106. http://dx.doi.org/10.15408/jkv.v4i2.8077.

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Recombinant protein Fim-C S.typhi is a potential protein that can be used as an alternative typhoid vaccine and produced on a large scale. However, before entering into a large-scale stage, laboratory optimum data on the factors that affect the production process of Fim-C Salmonella typhi proteins are required. This study aims to obtain information regarding the effect of host cell number E.coli BL21 (DE3) pLysS and overexpression time on production of recombinant protein Fim-C Salmonella typhi as the basis for developing candidate of typhoid vaccine. The optimization process of overexpression

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Vindurampulle, Christofer J., and Stephen R. Attridge. "Impact of Vector Priming on the Immunogenicity of Recombinant Salmonella Vaccines." Infection and Immunity 71, no. 1 (January 2003): 287–97. http://dx.doi.org/10.1128/iai.71.1.287-297.2003.

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ABSTRACT There are conflicting reports concerning the impact of prior vector priming on the immunogenicity of recombinant-Salmonella-based vaccines. A comparison of experimental protocols identified two variables which might account for this inconsistency: the potential of the vector strain to colonize the murine gut-associated lymphoid tissue (GALT) and the nature of the foreign antigen subsequently delivered by the recombinant Salmonella construct. The former was investigated by constructing an aroA mutant of the Salmonella enterica serovar Stanley vector previously used in our laboratory. A

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Kozarov, Emil, Naohisa Miyashita, Jacob Burks, Karen Cerveny, Thomas A. Brown, William P. McArthur, and Ann Progulske-Fox. "Expression and Immunogenicity of Hemagglutinin A from Porphyromonas gingivalis in an AvirulentSalmonella enterica Serovar Typhimurium Vaccine Strain." Infection and Immunity 68, no. 2 (February 1, 2000): 732–39. http://dx.doi.org/10.1128/iai.68.2.732-739.2000.

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ABSTRACT Porphyromonas gingivalis is a major etiologic agent of periodontitis, a chronic inflammatory disease that ultimately results in the loss of the supporting tissues of the teeth. Previous work has demonstrated the usefulness of avirulent Salmonella enterica serovar Typhimurium strains as antigen delivery systems for protective antigens of pathogens that colonize or cross mucosal surfaces. In this study, we constructed and characterized a recombinantS. enterica serovar Typhimurium avirulent vaccine strain which expresses hemagglutinin A and carries no antibiotic resistance markers. HagA,

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Torres-Escobar, Ascención, María Dolores Juárez-Rodríguez, Bronwyn M. Gunn, Christine G. Branger, Steven A. Tinge, and Roy Curtiss. "Fine-Tuning Synthesis of Yersinia pestis LcrV from Runaway-Like Replication Balanced-Lethal Plasmid in a Salmonella enterica Serovar Typhimurium Vaccine Induces Protection against a Lethal Y. pestis Challenge in Mice." Infection and Immunity 78, no. 6 (March 22, 2010): 2529–43. http://dx.doi.org/10.1128/iai.00005-10.

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ABSTRACT A balanced-lethal plasmid expression system that switches from low-copy-number to runaway-like high-copy-number replication (pYA4534) was constructed for the regulated delayed in vivo synthesis of heterologous antigens by vaccine strains. This is an antibiotic resistance-free maintenance system containing the asdA gene (essential for peptidoglycan synthesis) as a selectable marker to complement the lethal chromosomal ΔasdA allele in live recombinant attenuated Salmonella vaccines (RASVs) such as Salmonella enterica serovar Typhimurium strain χ9447. pYA4534 harbors two origins of repli

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Benyacoub, Jalil, Sally Hopkins, Alexandra Potts, Sandra Kelly, Jean-Pierre Kraehenbuhl, Roy Curtiss, Pierre De Grandi, and Denise Nardelli-Haefliger. "The Nature of the Attenuation of Salmonella typhimurium Strains Expressing Human Papillomavirus Type 16 Virus-Like Particles Determines the Systemic and Mucosal Antibody Responses in Nasally Immunized Mice." Infection and Immunity 67, no. 7 (July 1, 1999): 3674–79. http://dx.doi.org/10.1128/iai.67.7.3674-3679.1999.

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ABSTRACT We have recently shown by using a recombinant Salmonella typhimurium PhoPc strain in mice the feasibility of using a Salmonella-based vaccine to prevent infection by the genital human papillomavirus type 16 (HPV16). Here, we compare the HPV16-specific antibody responses elicited by nasal immunization with recombinant S. typhimurium strains harboring attenuations that, in contrast to PhoPc, are suitable for human use. For this purpose, χ4989 (Δcya Δcrp) and χ4990 [Δcya Δ(crp-cdt)] were constructed in the ATCC 14028 genetic background, and comparison was made with the isogenic PhoPc and

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Bidmeshki Barzoki, Tahereh, Ali Mohammad Ahadi, and Hoda Ayat. "A New Design and Epitopes Analysis for Recombinant Vaccine against Salmonella typhi by In silico Analysis." Trends in Immunotherapy 4, no. 2 (August 24, 2020): 1. http://dx.doi.org/10.24294/ti.v4.i2.891.

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Nowadays, foodborne diseases are one of the main problems of the world that infect humans due to consumption of contaminated water or food. Typhoid fever is one of the major causes of illness and death in the world caused by Salmonella typhi. Vaccination is one of the most effective approaches in order to reduction of the disease risk. The main goal of this study is designing and characterization of antigenic determinants of a fusion protein originated from S.typhi usable as an effective vaccine. In this study, the outer membrane proteins of salmonella have been considered as candidates confer

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Hui, F. M., C. L. Meng, N. N. Guo, L. G. Yang, F. X. Shi, and D. G. Mao. "Evaluation of attenuated Salmonella choleraesuis-mediated inhibin recombinant DNA vaccine in rats." Genetics and Molecular Research 13, no. 3 (2014): 6113–25. http://dx.doi.org/10.4238/2014.august.7.27.

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Rizos, Konstantin, Claus T. Lattemann, Dirk Bumann, Thomas F. Meyer, and Toni Aebischer. "Autodisplay." Infection and Immunity 71, no. 11 (November 2003): 6320–28. http://dx.doi.org/10.1128/iai.71.11.6320-6328.2003.

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ABSTRACT Live attenuated Salmonella strains expressing antigens of pathogens are promising oral vaccine candidates. There is growing evidence that the topology of expression of the foreign antigens can have a dramatic impact on the immunogenicity. We examined the potential of the AIDA-I (Escherichia coli adhesin involved in diffuse adherence) autotransporter domain to display antigenic fragments of the urease A subunit of Helicobacter pylori for the induction of a protective immune response. In the murine H. pylori model, protection is mainly mediated by CD4+ T cells, and we therefore used the

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Kohler, James J., Latha B. Pathangey, Sheila R. Gillespie, and Thomas A. Brown. "Effect of Preexisting Immunity to Salmonella on the Immune Response to Recombinant Salmonella enterica Serovar Typhimurium Expressing a Porphyromonas gingivalisHemagglutinin." Infection and Immunity 68, no. 6 (June 1, 2000): 3116–20. http://dx.doi.org/10.1128/iai.68.6.3116-3120.2000.

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ABSTRACT Recombinant Salmonella strains expressing foreign heterologous genes have been extensively studied as live oral vaccine delivery vectors. We have investigated the mucosal and systemic immune responses following oral immunization with a recombinantSalmonella enterica serovar Typhimurium expressing the hemagglutinin HagB from Porphyromonas gingivalis, a suspected etiological agent of adult periodontal disease. We have previously shown a primary mucosal and systemic response following oral immunization with χ4072/pDMD1 and recall responses following boosting at 14 weeks after primary imm

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Kulkarni, R. R., V. R. Parreira, Y. F. Jiang, and J. F. Prescott. "A Live Oral Recombinant Salmonella enterica Serovar Typhimurium Vaccine Expressing Clostridium perfringens Antigens Confers Protection against Necrotic Enteritis in Broiler Chickens." Clinical and Vaccine Immunology 17, no. 2 (December 9, 2009): 205–14. http://dx.doi.org/10.1128/cvi.00406-09.

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ABSTRACT Necrotic enteritis (NE) in broiler chickens is caused by Clostridium perfringens, and there is currently no effective vaccine for NE. We previously showed that in broiler chickens protection against NE can be achieved through intramuscular immunization with alpha toxin (AT) and hypothetical protein (HP), and we subsequently identified B-cell epitopes in HP. In the present study, we identified B-cell epitopes in AT recognized by chickens immune to NE. The gene fragments encoding immunodominant epitopes of AT as well as those of HP were codon optimized for Salmonella and cloned into pYA

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Kajikawa, Akinobu, Kazuya Masuda, Mitsunori Katoh та Shizunobu Igimi. "Adjuvant Effects for Oral Immunization Provided by Recombinant Lactobacillus casei Secreting Biologically Active Murine Interleukin-1β". Clinical and Vaccine Immunology 17, № 1 (18 листопада 2009): 43–48. http://dx.doi.org/10.1128/cvi.00337-09.

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ABSTRACT Vaccine delivery systems using lactic acid bacteria are under development, but their efficiency is insufficient. Autologous cytokines, such as interleukin-1β (IL-1β), are potential adjuvants for mucosal vaccines and can be provided by recombinant lactic acid bacteria. The aim of this study was the construction and evaluation of recombinant Lactobacillus casei producing IL-1β as an adjuvant delivery agent. The recombinant strain was constructed using an expression/secretion vector plasmid, including a mature IL-1β gene from mouse. The biological activity of the cytokine was confirmed b

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Lásaro, Marcio O., Wilson B. Luiz, Maria E. Sbrogio-Almeida, Lucilia S. Nishimura, Beatriz E. C. Guth, and Luis C. S. Ferreira. "Combined Vaccine Regimen Based on Parenteral Priming with a DNA Vaccine and Administration of an Oral Booster Consisting of a Recombinant Salmonella enterica Serovar Typhimurium Vaccine Strain for Immunization against Infection with Human-Derived Enterotoxigenic Escherichia coli Strains." Infection and Immunity 72, no. 11 (November 2004): 6480–91. http://dx.doi.org/10.1128/iai.72.11.6480-6491.2004.

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ABSTRACT Repeated evidence has demonstrated that combined primer-booster immunization regimens can improve both secreted and humoral immune responses to antigens derived from viral, bacterial, and parasitic pathogens. For the present work, we evaluated the synergic serum immunoglobulin G (IgG) and fecal IgA antibody responses elicited in BALB/c mice who were intramuscularly primed with a DNA vaccine, pRECFA, followed by oral boosting with an attenuated Salmonella enterica serovar Typhimurium vaccine (HG3) strain, with both vaccines encoding the structural subunit (CfaB) of the CFA/I fimbriae p

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Garmory, Helen S., Matthew W. Leckenby, Kate F. Griffin, Stephen J. Elvin, Rosa R. Taylor, M. Gill Hartley, Julian A. J. Hanak, E. Diane Williamson, and Rocky M. Cranenburgh. "Antibiotic-Free Plasmid Stabilization by Operator-Repressor Titration for Vaccine Delivery by Using Live Salmonella enterica Serovar Typhimurium." Infection and Immunity 73, no. 4 (April 2005): 2005–11. http://dx.doi.org/10.1128/iai.73.4.2005-2011.2005.

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ABSTRACT Live, attenuated bacteria are effective vectors for heterologous antigen delivery. However, loss of heterologous gene-bearing plasmids is problematic, and antibiotics and their resistance genes are not desirable for in vivo DNA vaccine delivery due to biosafety and regulatory concerns. To solve this problem, we engineered the first vaccine delivery strain that has no requirement for antibiotics or other selectable marker genes to maintain the recombinant plasmid. This model strain of Salmonella enterica serovar Typhimurium, SLDAPD, uses operator-repressor titration (ORT) technology, w

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Wang, Shifeng, Yuhua Li, Huoying Shi, Giorgio Scarpellini, Ascencion Torres-Escobar, Kenneth L. Roland, and Roy Curtiss. "Immune Responses to Recombinant Pneumococcal PsaA Antigen Delivered by a Live Attenuated Salmonella Vaccine." Infection and Immunity 78, no. 7 (May 17, 2010): 3258–71. http://dx.doi.org/10.1128/iai.00176-10.

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ABSTRACT Streptococcus pneumoniae is a leading cause of morbidity and mortality among children worldwide and particularly in developing countries. In this study, we evaluated PsaA, a conserved antigen important for S. pneumoniae adhesion to and invasion into nasopharynx epithelia, for its ability to induce protective immunity against S. pneumoniae challenge when delivered by recombinant attenuated Salmonella vaccine (RASVs) strains. RASVs were engineered to synthesize PsaA peptides of various lengths. Vaccination with an RASV synthesizing full-length PsaA induced high titers of anti-PsaA antib

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Bumann, Dirk. "In Vivo Visualization of Bacterial Colonization, Antigen Expression, and Specific T-Cell Induction following Oral Administration of Live Recombinant Salmonella enterica Serovar Typhimurium." Infection and Immunity 69, no. 7 (July 1, 2001): 4618–26. http://dx.doi.org/10.1128/iai.69.7.4618-4626.2001.

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ABSTRACT Live attenuated Salmonella strains that express a foreign antigen are promising oral vaccine candidates. Numerous genetic modifications have been empirically tested, but their effects on immunogenicity are difficult to interpret since important in vivo properties of recombinant Salmonella strains such as antigen expression and localization are incompletely characterized and the crucial early inductive events of an immune response to the foreign antigen are not fully understood. Here, methods were developed to directly localize and quantitate the in situ expression of an ovalbumin mode

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Berchtold, Christina, Klaus Panthel, Stefan Jellbauer, Brigitte Köhn, Elisabeth Roider, Miriam Partilla, Jürgen Heesemann, Stefan Endres, Carole Bourquin, and Holger Rüssmann. "Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium." Infection and Immunity 77, no. 12 (September 21, 2009): 5501–8. http://dx.doi.org/10.1128/iai.00700-09.

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ABSTRACT Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. To circumvent this problem, we injected CpG DNA admixed to the immunodominant p60217-225 peptide from Listeria monocytogenes subcutaneously into BALB/c mice and coadministered a p60-translocating Salmonella strain by the orogastric route. The distribution of tetramer-positive p60217-225-specific effector and memory CD8

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Dankel, Dorothy J., Kenneth L. Roland, Michael Fisher, Karen Brenneman, Ana Delgado, Javier Santander, Chang-Ho Baek, Josephine Clark-Curtiss, Roger Strand, and Roy Curtiss. "Making Common Sense of Vaccines: An Example of Discussing the Recombinant Attenuated Salmonella Vaccine with the Public." NanoEthics 8, no. 2 (July 10, 2014): 179–85. http://dx.doi.org/10.1007/s11569-014-0198-6.

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Xu, Can. "Construction of recombinant attenuated Salmonella typhimurium DNA vaccine expressingH pyloriureB and IL-2." World Journal of Gastroenterology 13, no. 6 (2007): 939. http://dx.doi.org/10.3748/wjg.v13.i6.939.

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Chin'ombe, Nyasha. "Recombinant Salmonella enterica Serovar Typhimurium as a Vaccine Vector for HIV-1 Gag." Viruses 5, no. 9 (August 28, 2013): 2062–78. http://dx.doi.org/10.3390/v5092062.

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Ashby, Deborah, Isabelle Leduc, Wallace Lauzon, B. Craig Lee, Neera Singhal, and D. William Cameron. "Attenuated Salmonella typhimurium SL3261 as a vaccine vector for recombinant antigen in rabbits." Journal of Immunological Methods 299, no. 1-2 (April 2005): 153–64. http://dx.doi.org/10.1016/j.jim.2005.02.005.

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Cieslak, Paul R., Zhang Tonghai, and Samuel L. Stanley Jr. "Expression of a recombinant Entamoeba histolytica antigen in a Salmonella typhimurium vaccine strain." Vaccine 11, no. 7 (May 1993): 773–76. http://dx.doi.org/10.1016/0264-410x(93)90264-x.

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Prejit, Rajesh Kumar Agarwal, Kannan Porteen, Zunjar B. Dubal, Karthikeyan Asha, Singh Shweta, and Biswas Ripan. "Evaluation of recombinant outer membrane protein based vaccine against Salmonella Typhimurium in birds." Biologicals 41, no. 3 (May 2013): 162–68. http://dx.doi.org/10.1016/j.biologicals.2013.01.003.

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Konjufca, Vjollca, Mark Jenkins, Shifeng Wang, Maria Dolores Juarez-Rodriguez, and Roy Curtiss. "Immunogenicity of Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Strains Carrying a Gene That Encodes Eimeria tenella Antigen SO7." Infection and Immunity 76, no. 12 (September 22, 2008): 5745–53. http://dx.doi.org/10.1128/iai.00897-08.

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ABSTRACT Recombinant attenuated Salmonella vaccines against avian coccidiosis were developed to deliver Eimeria species antigens to the lymphoid tissues of chickens via the type 3 secretion system (T3SS) and the type 2 secretion system (T2SS) of Salmonella. For antigen delivery via the T3SS, the Eimeria tenella gene encoding sporozoite antigen SO7 was cloned downstream of the translocation domain of the Salmonella enterica serovar Typhimurium sopE gene in the parental pYA3868 and pYA3870 vectors to generate pYA4156 and pYA4157. Newly constructed T3SS vectors were introduced into host strain χ8

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Wang, Zhihao, Jielan Mi, Yulong Wang, Tingting Wang, Xiaole Qi, Kai Li, Qing Pan, et al. "Recombinant Lactococcus Expressing a Novel Variant of Infectious Bursal Disease Virus VP2 Protein Can Induce Unique Specific Neutralizing Antibodies in Chickens and Provide Complete Protection." Viruses 12, no. 12 (November 25, 2020): 1350. http://dx.doi.org/10.3390/v12121350.

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Recent reports of infectious bursal disease virus (IBDV) infections in China, Japan, and North America have indicated the presence of variant, and the current conventional IBDV vaccine cannot completely protect against variant IBDV. In this study, we constructed recombinant Lactococcus lactis (r-L. lactis) expressing a novel variant of IBDV VP2 (avVP2) protein along with the Salmonella resistance to complement killing (RCK) protein, and Western blotting analysis confirmed that r-L. lactis successfully expressed avVP2-RCK fusion protein. We immunized chickens with this vaccine and subsequently

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Bird, Peter, Christine Hayes, James de Jersey, and Mark Bradley. "Construction and immunological assessment of Salmonella typhimurium expressing fox sperm LDH-C4." Reproduction, Fertility and Development 10, no. 3 (1998): 225. http://dx.doi.org/10.1071/r97076.

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This study examined immune responses of foxes to oral doses of recombinant Salmonella typhimurium expressing fox sperm-specific lactate dehydrogenase (fLDH). The cDNA for fLDH was cloned into the expression plasmid pKK233· 2 (pKKfLDH). Salmonella typhimuriumaroA– (SL3261) was transformed with either the pKK233·2 plasmid alone (SpKK) or the pKKfLDH construct (SpKfLDH). The fLDH expressed by SpKfLDH retained enzymatic activity and was recognized by human LDH-C4-specific antibody. Male European red foxes (Vulpes vulpes) were given an initial oral dose of 1 × 1011 cfu of either SpKK (control, n =

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Ghose, Chandrabali, Janneke M. Verhagen, Xinhua Chen, Jian Yu, Yaoxing Huang, Olivia Chenesseau, Ciarán P. Kelly, and David D. Ho. "Toll-Like Receptor 5-Dependent Immunogenicity and Protective Efficacy of a Recombinant Fusion Protein Vaccine Containing the Nontoxic Domains of Clostridium difficile Toxins A and B and Salmonella enterica Serovar Typhimurium Flagellin in a Mouse Model of Clostridium difficile Disease." Infection and Immunity 81, no. 6 (April 1, 2013): 2190–96. http://dx.doi.org/10.1128/iai.01074-12.

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ABSTRACTClostridium difficileis a spore-forming bacillus that produces toxin-mediated enteric disease.C. difficileexpresses two major virulence factors, toxin A (TcdA) and toxin B (TcdB). Human and animal studies demonstrate a clear association between humoral immunity to these toxins and protection againstC. difficileinfection (CDI). The receptor binding-domains (RBDs) of TcdA and TcdB are known to be immunogenic. Here, we tested the immunoadjuvant properties ofSalmonella entericaserovar Typhimurium flagellin (FliC) subunit D1 as an innate immune agonist expressed as a recombinant fusion vacc

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Soo, Shiu-Shing, Bernardo Villarreal-Ramos, C. M. Anjam Khan, Carlos E. Hormaeche, and Jenefer M. Blackwell. "Genetic Control of Immune Response to Recombinant Antigens Carried by an Attenuated Salmonella typhimuriumVaccine Strain: Nramp1 Influences T-Helper Subset Responses and Protection against Leishmanial Challenge." Infection and Immunity 66, no. 5 (May 1, 1998): 1910–17. http://dx.doi.org/10.1128/iai.66.5.1910-1917.1998.

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ABSTRACT Attenuated strains of Salmonella typhimurium have been widely used as vehicles for delivery and expression of vaccine antigens in murine models of infectious disease. In mice, early bacterial replication following infection with S. typhimurium is controlled by the gene (Nramp1, formerlyIty/Lsh/Bcg) encoding the natural-resistance-associated macrophage protein (Nramp1). Nramp1 regulates macrophage activation and has multiple pleiotropic effects, including regulation of tumor necrosis factor alpha, interleukin 1β (IL-1β), and major histocompatibility complex class II molecules, all of w

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Pan, Zhiming, Qiuxia Cong, Shizhong Geng, Qiang Fang, Xilong Kang, Meng You, and Xinan Jiao. "Flagellin from Recombinant Attenuated Salmonella enterica Serovar Typhimurium Reveals a Fundamental Role in Chicken Innate Immunity." Clinical and Vaccine Immunology 19, no. 3 (January 11, 2012): 304–12. http://dx.doi.org/10.1128/cvi.05569-11.

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ABSTRACTRecombinant attenuatedSalmonellavaccines have been extensively studied, with a focus on eliciting specific immune responses against foreign antigens. However, very little is known about the innate immune responses, particularly the role of flagellin, in the induction of innate immunity triggered by recombinant attenuatedSalmonellain chickens. In the present report, we describe twoSalmonella entericaserovar Typhimurium vaccine strains, wild-type (WT) or flagellin-deficient (flhD)Salmonella, both expressing the fusion protein (F) gene of Newcastle disease virus. We examined the bacterial

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