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Rozprawy doktorskie na temat „Recombinant vaccine”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Hand, Nicholas. "Development of a Recombinant Attenuated Salmonella Cancer Vaccine." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10635177.

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<p>New treatments for neuroblastoma are desperately needed; high-risk neuroblastoma patients have a less than 50% five-year survival rate despite intensive treatment. The greatest impact on improving survival rates for cancer patients in recent years is the result of a number of immunotherapeutic approaches. A proportion of high-risk neuroblastoma patients undergo spontaneous regression, possibly mediated by the immune system, indicating the potential of immunotherapies targeting neuroblastoma-associated antigens. Recombinant attenuated Salmonella vaccines (RASV) are cost-effective and have s

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Cook, Jeremy K. "Recombinant immunotargeting antigen, antibody fusions in vaccine design." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0001/NQ35130.pdf.

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Herr, Roger Alan. "Evaluation of Coccidioides posadasii antigens as recombinantly expressed monovalent, divalent, and chimeric vaccine candidates." Connect to full-text via OhioLINK ETD Center, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1160404292.

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Thesis (Ph.D.)--Medical University of Ohio, 2006.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences." Major advisor: Garry Cole. Includes abstract. Document formatted into pages: ii, 206 p. Title from title page of PDF document. Title at ETD Web site: Evaluation of two homologous Coccidioides posadasii antigens as recombinantly expressed monovalent, divalent, and chimeric vaccine candidates. Bibliography: pages 75-83, 116-120, 165-169, 185-204.

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4

Al-Zarouni, Mansour. "Expression of recombinant antigen in BCG." Thesis, University of Surrey, 2000. http://epubs.surrey.ac.uk/843308/.

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Little is known about the effect of different modes of expression of an antigen in rBCG on immune response. An appropriate wing of the immune system, with different degrees, is activated upon encounter with a foreign antigen. Knowledge of these responses is vital to the development of future recombinant vaccine. Various E. coli-mycobacterial species shuttle vector constructs were made using a combination of mycobacterial promoters and signal sequences. Thus enabling foreign antigens to be expressed cytoplasmically or secreted outside rBCG as native proteins or membrane-associated lipoproteins.

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Danet, Nicolas. "Molecular characterisation of the recombinant Vesicular Stomatitis Virus- ZEBOV-GP virus, prototype vaccine against Ebola virus." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1009/document.

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Ebolavirus (EBOV) est un filovirus responsable de fièvres hémorragiques virales sévères chez l’humain, qui peuvent être létales dans 90% des cas. L’actuelle épidémie en République Démocratique du Congo et l’ampleur démesurée de l'épidémie de 2014-2016 en Afrique de l’Ouest, qui a causé la mort de plus de 11 000 personnes, ont poussé les agences sanitaires internationales à tester plusieurs approches thérapeutiques afin d’essayer d’endiguer rapidement la propagation virale et de limiter la mortalité liée au virus lors de futures épidémies. Parmi toutes les stratégies testées, le virus recombina

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Teixeira, Lais Helena. "Geração e análise da imunogenicidade de proteínas recombinantes baseadas nas diferentes formas do antígeno circumsporozoíta de Plasmodium vivax visando o desenvolvimento de uma vacina universal contra malária." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-11072014-110149/.

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O P. vivax é a segunda espécie mais prevalente causadora de malária no mundo. Medidas de controle ineficientes exigem o desenvolvimento de novas estratégias de prevenção, como vacinas, novas drogas e novos inseticidas. O objetivo geral do trabalho foi gerar uma formulação vacinal universal com proteínas e adenovírus recombinantes capazes de induzir anticorpos contra as diferentes formas alélicas da proteína circumsporozoíta (CSP) do P. vivax. As proteínas foram produzidas em E. coli e purificadas por cromatografia de afinidade e troca iônica. A obtenção destas proteínas nos permitiu testar qua

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Saubi, Roca Narcís. "Scaling up recombinant BCG based HIV vaccine development. Lessons learned." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400667.

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El treball de recerca realitzat en aquesta Tesi Doctoral està dirigit a la millora del desenvolupament de la vacuna contra el VIH basada en BCG recombinant. La Tesi Doctoral inclou tres articles de recerca publicats en revistes “peer-reviewed” i una patent depositada a la Oficina Europea de Patents. Inicialment, hem avaluat la influencia de l’edat i la ruta d’immunització en la inducció de respostes immunes especifiques front a VIH i M. tuberculosis després d’immunitzar ratolins BALB/c recent nascuts i adults amb BCG.HIVA222 i reforçar-los amb Modified Virus Ankara (MVA).HIVA. Les frequ

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Ahuja, Sanjay. "Development of a recombinant protein vaccine against Plasmodium falciparum malaria /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-788-X/.

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Vaghefi, Negin Gitiban. "The role of innate immunity in protection against respiratory syncytial virus (RSV)." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1138388518.

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10

Okay, Sezer. "Development Of Recombinant Vaccines Composed Of Plpe And Omph From Pasteurella Multocida A:3." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613980/index.pdf.

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Pasteurella multocida serotype A:3 is a gram-negative bacterial pathogen which is one of the causative agents of shipping fever in cattle. In this study, ompH and two fragments of plpE gene (plpEN and plpEC) were cloned from the genomic DNA of P. multocida P-1062 (ATCC 15743, serotype A:3) and plpEN-ompH and plpEC-ompH fusions were constructed. In vitro expression of the genes was shown in HEK-293 cells. Later, full-length plpE gene was cloned and the recombinant proteins were expressed in E. coli and purified. Three DNA vaccine formulations, namely pCMV-ompH, pCMV-plpEN-ompH and pCMV-plpEC-om

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11

Amaral, Maria Rita Rebocho Lopes do. "Evaluation of a new vaccine based on pDNA and recombinant protein against Helicobacter pylori." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8520.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Helicobacter pylori is a bacterium capable of surviving and infecting a healthy human stomach and it is estimated that infect more than a half of world population. Despite of being almost always asymptomatic, in some cases, the infection can evolve to several gastric disease as chronic gastritis, peptic ulcers, gastric cancer and MALT lymphoma. Vaccination against H. pylori is a promising option due to emerging problems of antibiotics treatment. It is thought that oral immunization could be a good approach for

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12

Ramamoorthy, Sheela. "Approaches towards vaccine development against Neospora caninum." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/28054.

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Neospora caninum is an apicomplexan parasite that causes neuromuscular paralysis in dogs and abortions in cattle. N. caninum is responsible for losses of several million dollars to the dairy and beef industries in several parts of the world. The key players in the host immune response to N. caninum include CD4+ T cells, the Th1 cytokines IL-12, Interferon gamma and IgG2a isotype antibodies. There are currently no chemotherapeutic agents that are effective against adult cattle neosporosis. A commercially available, inactivated vaccine induces the undesirable Th2 type of immunity against N. cani

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13

Corgozinho, Carolina Nunes Costa. "Desenvolvimento de vacina baseada em sistema de liberação sustentada contendo proteína recombinante." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-31072009-083709/.

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No Brasil, e em outros paises de clima tropical, os carrapatos se tornaram um enorme problema economico de^$de que a industria do gado se desenvolveu. O carrapato Boophilus microplus, um dos artropodes mais importantes na veterinaria, causa efeitos direto, como suc,cao de sangue, e indireto, como a transmissao de uma grande variedade de patogenos que normalmente resulta em infec,c~es letais. As vacinas genicas contendo o antigeno Bm86, uma proteina ligada a membrana do intestino do carrapato B. microplus, representam uma alternativa atrativa aos acaricidas para controlar as infesta~oes por car

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14

Alharbi, Naif K. "New approaches for improving the immunogenicity of modified vaccinia virus Ankara as a recombinant vaccine vector." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:bbde86fd-ea8f-4e66-b260-f923d7e01e4b.

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Orubu, Toritse. "Generation of multivalent recombinant MVA vaccines for malaria." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589603.

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Modified vaccinia virus Ankara (MVA) has been used extensively as a recombinant vector for delivery of antigens from diverse pathogens. Its ability to generate strong antigen specific CD8+ T cell responses in humans has been shown in clinical trials of novel vaccines against malaria, tuberculosis, HIV I AIDS, influenza and cancer. The work in this thesis describes the use of BAC recombineering technology to harness the endogenous regulatory signal (promoter) that drives the expression of non-essential open reading frames (ORFs) in MVA for immunogenic expression of a recombinant antigen. Replac

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16

Sridhar, Saranya. "Development of recombinant adenoviral vectors as a pre-erythrocytic malaria vaccine." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497101.

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Alkahtani, Saad M. "Recombinant expression and immuno-screening for vaccine candidates in Plasmodium falciparum." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/12491.

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The main aim of this study was to develop a fast and efficient way of expressing <i>P. falciparum </i>antigenic epitopes as conformationally conserved antigenic structures whose expression can be readily ‘scaled-up’ for clinical testing. The <i>E. coli</i> and <i>P. pastoris</i> systems were used, both singly and as linked production systems using ‘shuttle vectors’ that can be dually expressed in both microorganisms. Initially a proof-of-principle experiment to express the CIDRI domain of PfEMP1 has been conducted. It was expressed and purified in good quantity and used to immunize rabbits. Th

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18

Taupin, Jean-Luc. "Anticorps monoclonaux dirigés contre la cytokine humaine HILDA/LIF : production au moyen de virus de la vaccine recombinants, caractérisation et mise au point d'un test ELISA pour le dosage du HILDA/LIF." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2P049.

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Al, Qublan Hamzeh. "Development and testing of recombinant B. abortus RB51 vaccine strains carrying M. tuberculosis protective antigens." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73696.

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Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most prevalent infectious diseases inflicting humankind. The World Health Organization estimates that one third of the world's population, approximately 2.2 billion people, is infected with TB with a mortality of 1.7 million people annually. Currently, the WHO estimates that each year more than 9 million people develop TB. Bacille Calmette-Guérin (BCG), an attenuated strain of M. bovis, is the only licensed TB vaccine in the world. Clinical studies have shown childhood vaccination with BCG to be protective against disseminating

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20

Bridge, Simon Harwood. "HIV-Neutralising response to recombinant, cross-clade, adjuvanted, VLP-forming vaccine candidates." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485898.

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The development of a safe, effective and affordable HIV-1 vaccine is urgently needed especially in resource poor settings. It is widely accepted that for a vaccine to confer sterilising immunity to HIV-1 it will have to elicit broadly neutralising antibodies (nAbs) to primary isolates of HIV but this goal has remained elusive. There are two key problems to be addressed in this regard: vaccine candidates have to express the correct epitopes capable of eliciting broadly cross-reactive neutralising antibodies to HIV, and they have to provide potent stimulatory signals to the relevant B cells so t

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Rajakumar, P. D. "The chloroplast of Chlamydomonas reinhardtii as a platform for recombinant vaccine production." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1532922/.

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Infectious diseases represent an on-going problem adversely affecting the poultry industries and fish farming. Protein-base vaccines that are currently used for the prevention and spread of diseases have several drawbacks including high cost of recombinant production and delivery; and the needs to eliminate endotoxins when produced in bacterial platforms such E. coli. Therefore, there is an urgent need for effective, cheaper and safer vaccines. The microalga Chlamydomonas reinhardtii could be an ideal candidate for the production of recombinant protein such as vaccines. This is because: i) it

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Labus, Marie B. "The production of a recombinant vaccine against the salmon louse Lepeophtheirus salmonis." Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU539163.

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Infestation of commercially reared salmonids with the salmon louse Lepeophtheirus salmonis, is a large problem for the fish farming industries in Scotland, Ireland and Norway. Lice infestations cause high fish mortalities and losses in revenue for the fish farmer. Conventional treatment of lice infestation involves the use of organophosphate insecticides which are limited in their efficacy against lice, as well as being highly toxic to the flora and fauna which surround the sea cages. We have investigated the possibility of producing a recombinant vaccine against L. salmonis based on immunisat

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Chun, Elizabeth M. "Developing a Recombinant Plant Virus Nanoparticle Vaccine for Rift Valley Fever Virus." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/scripps_theses/1345.

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Rift Valley Fever (RVF) is an emerging infectious disease found in both livestock and humans. RVF is associated with high abortion and mortality rates in livestock and can be fatal in humans. As such, RVF is economically and socially significant to affected smallholder and subsistence farmers, those infected, and national livestock industries. However, Rift Valley Fever virus (RVFV) vaccines are not commercially available outside of endemic areas or for humans, and current vaccines are limited in their safety and efficacy. A plant-based, viral nanoparticle vaccine offers a more affordable alte

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Nascimento, Ivan Pereira. "Expressão de antígenos de Bordetella pertussis em BCG Recombinante: subunidade 1 da toxina Pertussis e fragmento A da Hemaglutinina Filamentosa (FHA)." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-15022016-163854/.

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O desenvolvimento de vacinas multivalente constitui urna das prioridades na pesquisa de vacinas modernas. A utilização de vetores vivos para apresentação de antígenos heterólogos mostra-se bastante atraente, e eliminaria a necessidade de várias doses para se alcançar uma proteção máxima. Este tipo de vacina poderia ser administrado em dose única, o que poderia aumentar a cobertura vacinal. Neste trabalho foi explorado o potencial do Mycobacterium bovis BCG recombinante (rBCG) vivo expressando antígenos de Bordetella pertussis, como futuro componente de urna vacina tetravalente rBCG-DTP contra

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Ben, Chehida Regaya Faten. "Etude de la variole ovine en Tunisie et caractérisation des protéines virales impliquées dans la réponse immunitaire anti-capripoxvirus." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT021.

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Le virus de la variole ovine est omniprésent dans les élevages de petits ruminants dans les pays d’Afrique du Nord et particulièrement en Tunisie malgré les campagnes de vaccination annuelles mises en place par les autorités vétérinaires du pays. L’optimisation de la souche vaccinale utilisée passe par le développement de vaccins dits de nouvelle génération tels que les vaccins sous unitaires utilisant des protéines reconnues pour induire une réponse humorale protectrice chez l’animal immunisé. Ceci pourrait être une alternative aux stratégies de lutte actuelles permettant de limiter la dissém

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Branco, Juliana Inês. "Avaliação da imunogenicidade de diferentes formas alélicas da proteína recombinante PvAMA-1expressa em Pichia pastoris: impacto da diversidade antigênica." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9142/tde-12112018-145334/.

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A malária é um problema de saúde pública no Brasil e no mundo. Em 2016, o número de casos estimado pela Organização Mundial de Saúde foi de 216 milhões. Plasmodium falciparum é a espécie mais prevalente e responsável pelo maior número de mortes no mundo, sobretudo no continente africano. Por outro lado, o Plasmodium vivax é conhecido por sua ampla distribuição geográfica, sendo a espécie que predomina nas Américas, incluindo o Brasil. Nos últimos 20 anos, nosso grupo tem gerado e caracterizado diversas proteínas recombinantes baseadas em antígenos imunodominantes de P. vivax que podem servir c

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Thomas, Robin. "Recombinant BCG expressing HIV-1 C GAG : selection of the vaccine gene and construction and evaluation as a vaccine candidate." Doctoral thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/2739.

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Piquart, François. "Les vaccins recombinants : données actuelles." Paris 5, 1989. http://www.theses.fr/1989PA05P110.

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Carre, Heather Emily. "Expression and analysis of recombinant mycoplasma hyponeumoniae proteins as potential subunit vaccine candidates." Thesis, Royal Veterinary College (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522182.

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Breau, Cathy. "Development of an oral recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28079.

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Chancroid, a sexually transmitted genital ulcer disease caused by the Gram-negative bacterium Haemophilus ducreyi, facilitates the acquisition and transmission of H1V. An effective vaccine against chancroid has yet to be developed. We hypothesize that a Salmonella vector-based vaccine, expressing H. ducreyi antigens, could confer protective immunity in the rabbit model of H. ducreyi infection. The H. ducreyi outer membrane hemoglobin receptor HgbA has been shown to be a suitable vaccine candidate. HgbA was expressed from S. typhimurium SL3261 (pnirBhgbA) but not from the control strain, S. typ

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Halle, Briana. "Production of a Cost-Effective, TMV-Based Rabies Vaccine through Recombinant DNA Technology." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1816.

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Infectious diseases remain a significant cause of human deaths, as approximately 15 million deaths were attributed to infectious diseases in 2010 (Dye, 2014). One such disease is rabies, which causes around 59,000 human deaths worldwide annually according to some estimates (Kessels et al., 2017). However, 95% of human deaths attributed to rabies occur in Asia and Africa (Singh et al., 2017). Rabies is preventable, yet it is still a major concern in developing, low-income countries that lack access to the medical care necessary to combat it (Hampson et al., 2015). Alternative techniques for low

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Judd, Fairbanks Lyndon. "Construction of a recombinant fowlpox virus as a vaccine against avian lymphoid leukosis." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315077.

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Dennehy, Maureen. "Recombinant BCG expressing rotavirus VP6 : construction and evaluation as an anti-rotavirus vaccine." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/2725.

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Tabar, Gholam Reza Hashemi. "Selection of peptides from random peptide libraries for a recombinant vaccine against dermatophilosis." Thesis, Tabar, Gholam Reza Hashemi (1998) Selection of peptides from random peptide libraries for a recombinant vaccine against dermatophilosis. PhD thesis, Murdoch University, 1998. https://researchrepository.murdoch.edu.au/id/eprint/53219/.

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Dermatophilosis commonly known as "lumpy wool" in sheep in Australia, is a skin disease of animals and man caused by Dermatophilus congolensis. In sheep dermatophilosis causes significant wool production losses both directly and indirectly due to down grading of wool and hides, low meat production and high mortality. particularly in young sheep. Control of the disease by vaccination is desirable but has only been partially successful and antigens are difficult to produce in sufficient quantity from D. congolensis. Dr T.M. Ellis and colleagues (Agriculture WA) have developed a vaccine that can

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O’Meara, Kellie Marcella. "Evaluation of Recombinant Salmonella Expressing CD154 for Enhanced Immune Responses in Commercial Turkeys." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1246567532.

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Teixeira, Aline Rodrigues Florencio. "Avaliação e caracterização de candidatos vacinais voltados para o controle da leptospirose." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-25082016-100745/.

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A leptospirose é uma doença sistêmica, causada por bactérias patogênicas do gênero Leptospira. O desenvolvimento de novas estratégias para prevenir a doença é necessário. Vacinas surgem como fortes candidatas para contornar o problema. As pesquisas atuais têm interesse em identificar antígenos conservados que estão envolvidos nas interações patógeno-hospedeiro.O presente projeto selecionou três proteínas hipotéticas de L. interrogans para serem caracterizadas quanto ao seu papel na patogênese e avaliadas quanto ao seu potencial protetor. Os genes foram amplificados por PCR e clonados no vetor

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Mendes, Jéssica Mariane Ferreira. "Produção e Avaliação de antígenos recombinantes candidatos a componente de uma vacina contra leishmaniose visceral canina." reponame:Repositório Institucional da FIOCRUZ, 2016. https://www.arca.fiocruz.br/handle/icict/14161.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2016-05-10T16:21:40Z No. of bitstreams: 1 Jessica Mariane Ferreira Mendes Produção... 2016.pdf: 1965926 bytes, checksum: ac5119592b97390470f4914f6fcbddf0 (MD5)<br>Approved for entry into archive by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2016-05-10T16:21:54Z (GMT) No. of bitstreams: 1 Jessica Mariane Ferreira Mendes Produção... 2016.pdf: 1965926 bytes, checksum: ac5119592b97390470f4914f6fcbddf0 (MD5)<br>Made available in DSpace on 2016-05-10T16:21:54Z (GMT). No. of bitstreams: 1 Jessica Mariane Ferreira Mendes

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Poobalane, Saravanane. "Aeromonas hydrophila vaccine development using immunoproteomics." Thesis, University of Stirling, 2007. http://hdl.handle.net/1893/195.

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Aeromonas hydrophila is an opportunistic pathogen that causes a wide range of symptoms and diseases in fish. Development of a commercial vaccine has been problematic due to the heterogenicity between isolates of A. hydrophila. A new approach using immunoproteomics was used in this study to try to develop a vaccine that would protect against a wide range of A. hydrophila strains. The virulence of 14 isolates of A. hydrophila from different geographical regions was determined in common carp (Cyprinus carpio) indicating that 6 isolates were virulent, while 8 isolates were avirulent. Expression of

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Kalicharran, Kishna Kumar. "Studies on the stability, production and microencapsulation of a recombinant human adenovirus-rabies vaccine." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7579.

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The recombinant human adenovirus type 5 (rHAd5-RG1) tested in this study contains the rabies virus glycoprotein gene. This virus is being considered as a possible substitute for the attenuated rabies virus in the oral immunization of wildlife in Ontario. This study examined the stability of the virus indoors and outdoors, and tested technically simple ways of concentrating the virus and its microencapsulation. The findings of this study show that the recombinant virus has the potential for release into the environment and there is no evidence that the virus will rapidly decay under the outdoor

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Kuzyk, Michael Allan. "Development of an efficacious recombinant vaccine for the obligate intracellular salmonid pathogen Piscirickettsia salmonis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0010/NQ52764.pdf.

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Lu, Dongmei Hickey Anthony J. "Aerosol delivery of recombinant antigen 85B in microparticle vaccine systems for protection against tuberculosis." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1388.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmaceutical Sciences." Discipline: Pharmaceutical Sciences; Department/School: Pharmacy.

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Silva, Maria Elizabeth. "Development of a Recombinant Attenuated Salmonella Vaccine System for Taenia Solium Cysticercosis in Pigs." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/81.

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Taenia solium is a cestode that has a two-hosts life cycle. The adult tapeworm causes an asymptomatic disease known as taeniasis whereas the larval stage causes a disease called cysticercosis. In humans, the most common localization for the larvae is the central nervous system where it produces the neurological disorder neurocysticerco-sis. Previous works by several research groups around the world have shown that T. so-lium is a potentially eradicable parasite. Control programs have included treatment of human and pig populations with antihelmintics in conjunction with health education and ar

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Dar, Nosheen. "Development of replication defective recombinant adenoviruses for the purpose of HIV-1 vaccine delivery." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429507.

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Sheih, Tianna. "Development of a Dengue Fever Vaccine from Recombinant DENV2 Protein and Tobacco Mosaic Virus." Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/scripps_theses/810.

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Dengue fever is a rapidly growing concern to human health and is currently the most prevalent mosquito-borne viral disease worldwide. Although there are several vaccine candidates being tested in clinical trials, there are no vaccines publicly available to prevent this disease. Plant-based vaccines are rapidly becoming viable alternatives to traditional animal-based vaccines because they are safe, easy to manufacture, and more cost-efficient. The purpose of this project is to develop a vaccine against the dengue virus by producing a recombinant DENV2 protein, engineered by Dr. David Lo and his

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Ralikhwatha, Tovhowani Daphney. "Development and evaluation of a recombinant vaccine against Clostridium perfringens type D epsilon toxin." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/79304.

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Enterotoxemia, an economically important disease of sheep, goats and calves, is caused by systemic effects of the epsilon toxin produced by the anaerobic bacterium Clostridium perfringens Type D. To combat the disease, a vaccine consisting of formalin-inactivated Type D toxin is available, but several concerns regarding its production have been raised. The development of efficacious recombinant subunit vaccines can provide a means whereby many of the production problems may be eliminated or minimized. However, the production of purified antigens is often associated with weakened antigen immuno

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au, T. La@murdoch edu, and Tom La. "Characterisation, Recombinant Expression and Immunogenicity of BHLP29.7, An Outer Membrane Lipoprotein of Brachyspira Hyodysenteriae." Murdoch University, 2006. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20070830.141953.

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Swine dysentery (SD) is an important endemic infection in many piggeries, and control can be problematic. In this study, the gene encoding a 29.7 kDa outer membrane lipoprotein of the causative intestinal spirochaete Brachyspira hyodysenteriae, was identified and sequenced. An 816 bp hypothetical open reading frame (ORF) was identified, with a potential ribosome binding site, and putative 10 and 35 promoter regions upstream from the start of the ORF. The 29.7 kDa outer membrane lipoprotein was designated Bhlp29.7 and the encoding gene named bhlp29.7. The amino acid sequence of Bhlp29.7 incl

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com, tickle_me_patty@hotmail, and Patrick Leslie Shearer. "Development of Novel Diagnostic and Vaccine Options for Beak and Feather Disease Virus." Murdoch University, 2009. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20090720.142800.

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Beak and Feather Disease Virus (BFDV) is a circovirus which causes ill-thrift, feather loss and immunosuppression leading to secondary infections and eventually death in psittacine birds. The development of standardised reagents for the detection and characterisation of BFDV infections and for the production of protective vaccines has been difficult as no cell culture system has yet been found to grow the virus successfully in vitro. However, the development of consistent and effective diagnostic tests and vaccines is now more practical through the application of nucleic acid-based detection m

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Cavalcanti, Marcos Antônio Rocha. "Efeito de vacinas alopática e homeopática frente a Mycobacterium spp em diferentes modelos animais." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3148.

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Kremer, Courtney J. "Evaluation of Recombinant Salmonella Expressing the Flagellar Protein FliC for Enhanced Immune Responses in Commercial Turkeys." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1246568225.

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Eldaghayes, Ibrahim Mohamed. "Use of chicken interleukin-18 as a vaccine adjuvant with a recombinant fowlpox virus fpIBD1, a subunit vaccine giving partial protection against IBDV." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419211.

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