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Artykuły w czasopismach na temat „Red cell ligands”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Smith, Christof, Sarah Entwistle, Caryn Willis, et al. "478 Translation of a therapeutic neoantigen vaccine workflow to SARS-CoV-2 vaccine development." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A510—A512. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0478.

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BackgroundThere is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE) (figure 1). Leveraging methods initially developed for prediction of tumor-specific antigen targets, we combine computational prediction of T cell epitopes, recently published B cell epitope mapping studies, and epitope access

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2

Li, Tong, Nan Li, Yao Ma, Yun-Jie Bai, Cheng-Mei Xing, and Yong-Kuan Gong. "A blood cell repelling and tumor cell capturing surface for high-purity enrichment of circulating tumor cells." Journal of Materials Chemistry B 7, no. 40 (2019): 6087–98. http://dx.doi.org/10.1039/c9tb01649j.

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Irmler, Manfred, and Gerd Meyer. "Notizen: Molekülstruktur von Re3Cl6(Acac)3 im Feststoff / Molecular Structure of Re3Cl6(Acac)3 in the Solid State." Zeitschrift für Naturforschung B 45, no. 7 (1990): 1103–4. http://dx.doi.org/10.1515/znb-1990-0735.

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Dark red single crystals of Re3Cl6(Acac)3 are obtained from a solution of “ReCl3·2H2O” in acetylacetone by slow evaporation. The unit cell (monoclinic, P21/c, a = 1687.3(9), b = 963.4(5), c = 1664.3(9) pm, β = 108.97(4)°) contains four molecules of Re3Cl6(Acac)3. Each of the bidentate Acac(—) ligands substitutes one of the in-plane terminal and one of the out-of-plane terminal ligands with respect to the Re3 triangle.

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4

Marginedas-Freixa, Irene, Cora Alvarez, Martina Moras, et al. "Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands." International Journal of Molecular Sciences 19, no. 10 (2018): 3098. http://dx.doi.org/10.3390/ijms19103098.

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Two main isoforms of the Translocator Protein (TSPO) have been identified. TSPO1 is ubiquitous and is mainly present at the outer mitochondrial membrane of most eukaryotic cells, whereas, TSPO2 is specific to the erythroid lineage, located at the plasma membrane, the nucleus, and the endoplasmic reticulum. The design of specific tools is necessary to determine the molecular associations and functions of TSPO, which remain controversial nowadays. We recently demonstrated that TSPO2 is involved in a supramolecular complex of the erythrocyte membrane, where micromolar doses of the classical TSPO

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5

Paulitschke, M., GB Nash, DJ Anstee, MJ Tanner, and WB Gratzer. "Perturbation of red blood cell membrane rigidity by extracellular ligands." Blood 86, no. 1 (1995): 342–48. http://dx.doi.org/10.1182/blood.v86.1.342.bloodjournal861342.

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It is known that binding of extracellular antibodies against the major sialoglycoprotein, glycophorin A, reduced the deformability of the red blood cell membrane. This has been taken to result from new or altered interactions between the glycophorin A and the membrane skeleton. We have shown by means of the micropipette aspiration technique that antibodies against the preponderant transmembrane protein, band 3, induce similar effects. A definite but much smaller reduction in elasticity of the membrane is engendered by univalent Fab fragments of the anti-band 3 antibodies. By examining cells ge

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6

Smet, P. W., T. F. Pauwels, and P. J. Dierickx. "The effect of hexaaza-and hexathia–macrocyclic ligands on transition metal cytotoxicity in human hepatoma-derived cultured cells." Human & Experimental Toxicology 21, no. 8 (2002): 421–27. http://dx.doi.org/10.1191/0960327102ht277oa.

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The effect of macrocyclic ligands on cytotoxic concentrations of the transition metal ions of copper, zinc, and cadmium was investigated. For this purpose, a hexaaza-[3,6,9,17,20,23-hexaazatricyclo[23.3.1.111,15] triaconta–1(29),11(30),12,14,25,27–hexaene (L2)] and hexathia-chelating ligand [1,4,7,10,13,16-hexathiacyclooctadecane (L3)] were used in the human hepatoma-derived HepG2 cell line. The cytotoxicity was measured by the neutral red uptake inhibition assay. First, the NI50 of the ligands, i.e., the concentration of the ligand inducing a 50% inhibition in neutral red uptake compared to c

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7

Cao, Fei, Antonio Castrillo, Peter Tontonoz, Fabio Re, and Gerald I. Byrne. "Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2." Infection and Immunity 75, no. 2 (2006): 753–59. http://dx.doi.org/10.1128/iai.01386-06.

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ABSTRACT Chlamydia pneumoniae induces macrophage foam cell formation, a hallmark of early atherosclerosis, in the presence of low-density lipoprotein (LDL). This study examined the role that Toll-like receptor 2 (TLR2) and TLR4 may play in pathogen-induced foam cell formation. Murine macrophage RAW 264.7 cells either infected with C. pneumoniae or treated with the TLR4 ligand E. coli lipopolysaccharide (LPS) or the TLR2 ligand Pam3-Cys-Ala-Gly-OH (Pam) became Oil Red O-stained foam cells and showed increased cholesteryl ester (CE) content when cocultured with LDL. In macrophages from TLR2−/− m

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8

Farrés, Judith, Susanna Burckhardt-Herold, Jan Scherrer, Alexander D. Frey, and Pauli T. Kallio. "Analysis of the contribution of the globin and reductase domains to the ligand-binding properties of bacterial haemoglobins." Biochemical Journal 407, no. 1 (2007): 15–22. http://dx.doi.org/10.1042/bj20070668.

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Bacterial Hbs (haemoglobins), like VHb (Vitreoscilla sp. Hb), and flavoHbs (flavohaemoglobins), such as FHP (Ralstonia eutropha flavoHb), have different autoxidation and ligand-binding rates. To determine the influence of each domain of flavoHbs on ligand binding, we have studied the kinetic ligand-binding properties of oxygen, carbon monoxide and nitric oxide to the chimaeric proteins, FHPg (truncated form of FHP comprising the globin domain alone) and VHb-Red (fusion protein between VHb and the C-terminal reductase domain of FHP) and compared them with those of their natural counterparts, FH

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Rosin-Arbesfeld, Rina, Michal Caspi, Ronen Siman-Tov, Yakir Levi, and Chava Perry. "Wnt Signaling in Red Blood Cells." Blood 128, no. 22 (2016): 4806. http://dx.doi.org/10.1182/blood.v128.22.4806.4806.

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Abstract Introduction : Red blood cells (RBCs) are the most common cell type in the human body. These cells deliver oxygen to the body's tissues and are composed of a cytoplasm that is rich in hemoglobin and is surrounded by a membrane that is essential for the cells function by providing properties such as stability and deformability. The membrane is composed of a lipid bilayer, transmembrane proteins, and a filamentous meshwork of proteins such as actin and adducin that forms the cells cytoskeleton along the entire cytoplasmic surface of the membrane. RBCs lack a nucleus and other cellular o

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10

Mangalmurti, Nilam S., Jessica Friedman, Don L. Siegel, Janet Lee, and Steven M. Albelda. "Erythrocyte Advanced Glycation End-Products as Novel Mediators of Endothelial Dysfunction Following Transfusion." Blood 120, no. 21 (2012): SCI—47—SCI—47. http://dx.doi.org/10.1182/blood.v120.21.sci-47.sci-47.

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Abstract Abstract SCI-47 Red cell transfusions are associated with the development of acute lung injury in critically ill patients, yet the mechanisms for this association remain unknown. We have previously shown that stored red blood cells (RBCs) express the advanced glycation end-product Nε-carboxymethyl lysine (Nε-CML) (1). Advanced glycation end-products (AGEs), a heterogeneous group of adducts formed during states of increased oxidative stress or hyperglycemia, are thought to exert their effects by binding to membrane receptors, including RAGE (the receptor for advanced glycation-end prod

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11

Li, Jing, Zhi Wang, Minxia Fan, Guangwan Hu, and Mingquan Guo. "Potential Antioxidative and Anti-Hyperuricemic Components Targeting Superoxide Dismutase and Xanthine Oxidase Explored from Polygonatum Sibiricum Red." Antioxidants 11, no. 9 (2022): 1651. http://dx.doi.org/10.3390/antiox11091651.

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Polygonatum sibiricum Red. (P. sibiricum) has been used as a traditional Chinese medicine with a wide range of pharmacology effects. However, the responsible bioactive compounds and their mechanisms of action concerning its antioxidative and anti-hyperuricemic activities remain unexplored. In this work, the antioxidant capacity of P. sibiricum was firstly evaluated with the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azinobis-(3ethylbenzthiazoline)-6-sulfonic acid (ABTS) and ferric-reducing antioxidant power (FRAP) assays, from which the ethyl acetate (EA) fraction exhibited the highest DPPH, A

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12

Monga, Sheelu, Nunzio Denora, Valentino Laquintana, Rami Yashaev, Abraham Weizman, and Moshe Gavish. "The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson’s Disease." Biology 10, no. 11 (2021): 1183. http://dx.doi.org/10.3390/biology10111183.

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder which is characterized by the degeneration of dopaminergic neurons in substantia nigra (SN). Oxidative stress or reactive oxygen species (ROS) generation was suggested to play a role in this specific type of neurodegeneration. Therapeutic options which can target and counteract ROS generation may be of benefit. TSPO ligands are known to counteract with neuro-inflammation, ROS generation, apoptosis, and necrosis. In the current study, we investigated an in vitro cellular PD model by the assessment of 6-hydroxydopamine (6-OHDA,

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13

Shumaev, Konstantin B., Irina V. Gorudko, Olga V. Kosmachevskaya, et al. "Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid." Oxidative Medicine and Cellular Longevity 2019 (April 8, 2019): 1–12. http://dx.doi.org/10.1155/2019/2798154.

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Hypochlorous acid (HOCl), one of the major precursors of free radicals in body cells and tissues, is endowed with strong prooxidant activity. In living systems, dinitrosyl iron complexes (DNIC) with glutathione ligands play the role of nitric oxide donors and possess a broad range of biological activities. At micromolar concentrations, DNIC effectively inhibit HOCl-induced lysis of red blood cells (RBCs) and manifest an ability to scavenge alkoxyl and alkylperoxyl radicals generated in the reaction of HOCl withtert-butyl hydroperoxide. DNIC proved to be more effective cytoprotective agents and

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14

Goldston, Amanda M., Rhonda R. Powell, Amrita B. Koushik, and Lesly A. Temesvari. "Exposure to Host Ligands Correlates with Colocalization of Gal/GalNAc Lectin Subunits in Lipid Rafts and Phosphatidylinositol (4,5)-Bisphosphate Signaling in Entamoeba histolytica." Eukaryotic Cell 11, no. 6 (2012): 743–51. http://dx.doi.org/10.1128/ec.00054-12.

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ABSTRACT Entamoeba histolytica is an intestinal parasite that causes dysentery and liver abscess. Parasite cell surface receptors, such as the Gal/GalNAc lectin, facilitate attachment to host cells and extracellular matrix. The Gal/GalNAc lectin binds to galactose or N -acetylgalactosamine residues on host components and is composed of heavy (Hgl), intermediate (Igl), and light (Lgl) subunits. Although Igl is constitutively localized to lipid rafts (cholesterol-rich membrane domains), Hgl and Lgl transiently associate with this compartment in a cholesterol-dependent fashion. In this study, tro

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15

Lavoie, R. Ashton, Alice di Fazio, Ruben G. Carbonell, and Stefano Menegatti. "Multiplexed Competitive Screening of One-Bead-One-Component Combinatorial Libraries Using a ClonePix 2 Colony Sorter." International Journal of Molecular Sciences 20, no. 20 (2019): 5119. http://dx.doi.org/10.3390/ijms20205119.

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Screening solid-phase combinatorial libraries of bioactive compounds against fluorescently labeled target biomolecules is an established technology in ligand and drug discovery. Rarely, however, do screening methods include comprehensive strategies—beyond mere library blocking and competitive screening—to ensure binding selectivity of selected leads. This work presents a method for multiplexed solid-phase peptide library screening using a ClonePix 2 Colony Picker that integrates (i) orthogonal fluorescent labeling for positive selection against a target protein and negative selection against c

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16

Liu, Tao, Ru Bai, Huige Zhou, et al. "The effect of size and surface ligands of iron oxide nanoparticles on blood compatibility." RSC Advances 10, no. 13 (2020): 7559–69. http://dx.doi.org/10.1039/c9ra10969b.

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Due to the unique physicochemical properties, superparamagnetic iron oxide nanoparticles (SPIONs) have attracted increased attention, which show different effects on red blood cell, plasma, platelet, C3 complement and vascular endothelial cell.

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Soler, M., M. González-Bártulos, E. Figueras, et al. "Delivering aminopyridine ligands into cancer cells through conjugation to the cell-penetrating peptide BP16." Organic & Biomolecular Chemistry 14, no. 17 (2016): 4061–70. http://dx.doi.org/10.1039/c6ob00470a.

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El Nemer, Wassim, Marie-Paule Wautier, Cécile Rahuel та ін. "Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell α4β1integrin: role in adhesion of sickle red blood cells to endothelial cells". Blood 109, № 8 (2006): 3544–51. http://dx.doi.org/10.1182/blood-2006-07-035139.

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Abstract The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin α5 chain. In addition to red blood cells, Lu/BCAM proteins are highly expressed in endothelial cells. Abnormal adhesion of red blood cells to the endothelium could potentially contribute to the vaso-occlusive episodes in sickle cell disease. Considering the presence of integrin consensus-binding sites in Lu/BCAM proteins, we investigated their potential interaction with integrin α4β1, the uni

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Sarkar, Parijat, Kaleeckal G. Harikumar, Satinder S. Rawat, Sanjib Das, Tushar K. Chakraborty, and Amitabha Chattopadhyay. "Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors." Molecules 26, no. 13 (2021): 3848. http://dx.doi.org/10.3390/molecules26133848.

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Serotonin is a neurotransmitter that plays a crucial role in the regulation of several behavioral and cognitive functions by binding to a number of different serotonin receptors present on the cell surface. We report here the synthesis and characterization of several novel fluorescent analogs of serotonin in which the fluorescent NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) group is covalently attached to serotonin. The fluorescent ligands compete with the serotonin1A receptor specific radiolabeled agonist for binding to the receptor. Interestingly, these fluorescent ligands display a high environm

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Mangalmurti, Nilam S., Jessica L. Friedman, Liang-Chuan Wang, et al. "The receptor for advanced glycation end products mediates lung endothelial activation by RBCs." American Journal of Physiology-Lung Cellular and Molecular Physiology 304, no. 4 (2013): L250—L263. http://dx.doi.org/10.1152/ajplung.00278.2012.

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The receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor implicated in multiple disease states. Although RAGE is expressed on systemic vascular endothelium, the expression and function of RAGE on lung endothelium has not been studied. Utilizing in vitro (human) and in vivo (mouse) models, we established the presence of RAGE on lung endothelium. Because RAGE ligands can induce the expression of RAGE and stored red blood cells express the RAGE ligand Nε-carboxymethyl lysine, we investigated whether red blood cell (RBC) transfusion would augment RAGE e

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Carrancio, Soraya, Jennifer A. Markovics, Piu Wong та ін. "Sotatercept Promotes Differentiation and Survival Of Erythroid Progenitors By Blocking Inhibitory Effects Of TGFβ Superfamily Members". Blood 122, № 21 (2013): 944. http://dx.doi.org/10.1182/blood.v122.21.944.944.

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Abstract Erythropoiesis, the process of cell proliferation and differentiation that produces erythrocytes, is a tightly regulated process, but apart from early progenitor development and the EPO-dependent response, very little is known about other molecular signals which control cellular fate during RBC production. Members of the transforming growth factor beta (TGFβ) superfamily have been studied as potential regulators of erythropoiesis, iron regulation and globin expression. Sotatercept, an ActRIIA ligand trap, binds to and inhibits activin and other members of the TGFβ superfamily to induc

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Ibragimova, M. Y., V. V. Semenov, Ya Kh Kh Ibragimov, Sh Z. Validov, and R. I. Zhdanov. "Genetic effects of medicines - lipid exchange modulators." Genes & Cells 9, no. 3 (2014): 199–203. http://dx.doi.org/10.23868/gc120301.

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There are medicines known as adrenoreceptors ligands, which influences a variety of lipid exchange, therefore the study of their mutagenic and antimutagenic potentials, their genotoxicity, is of great interest. The study are fullfiled using C57B4/6 mice (males) of 20 g and 1,5-2 months of age. Mutagenic and antimutagenic effects of the ligands were evaluated using in vivo tests: mouse brain skeleton cells (a number of chromosomal aberrations) and mouse peripheral red blood cells peripheral (a number of cells with micronuclei from 2000 analyzed cells). 6 male mice were used for every experiment

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Kostova, Irena, Georgi Momekov, Tzvetomira Tzanova, and Margarita Karaivanova. "Synthesis, Characterization, and Cytotoxic Activity of New Lanthanum(III) Complexes of Bis-Coumarins." Bioinorganic Chemistry and Applications 2006 (2006): 1–9. http://dx.doi.org/10.1155/bca/2006/25651.

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Complexes of lanthanum(III) with bis-coumarins: 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) (H2L1) and bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-(1H-pyrazol-3-yl)-methane (H2L2) were synthesized by reaction of lanthanum(III) salt and the ligands, in amounts equal to metal: ligand molar ratio of1:2. The complexes were prepared by adding an aqueous solution of lanthanum(III) salt to an aqueous solution of the ligand subsequently raising the pH of the mixture gradually to circa 5.0 by adding dilute solution of sodium hydroxide. The lanthanum(III) complexes with bis-coumarins were characteriz

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Alves-Rosa, María Fernanda, Nicole M. Tayler, Doriana Dorta, Lorena M. Coronado, and Carmenza Spadafora. "P. falciparum Invasion and Erythrocyte Aging." Cells 13, no. 4 (2024): 334. http://dx.doi.org/10.3390/cells13040334.

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Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose receptors for the pathogen ligands and, on the other hand, maintain the right geometry to facilitate merozoite attachment and entry into the red blood cell. Both characteristics change with the maturation of erythrocytes. Some Plasmodia prefer younger vs. older erythrocytes. How does the life evolution of the RBC affect the invasion of the parasite? What happens when the RBC ages? In this review, we present what is known up until now.

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Martínez-Muñoz, Alberto, Berenice Prestegui-Martel, David Méndez-Luna, et al. "Selection of a GPER1 Ligand via Ligand-based Virtual Screening Coupled to Molecular Dynamics Simulations and Its Anti-proliferative Effects on Breast Cancer Cells." Anti-Cancer Agents in Medicinal Chemistry 18, no. 11 (2019): 1629–38. http://dx.doi.org/10.2174/1871520618666180510121431.

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Background: Recent reports have demonstrated the role of the G Protein-Coupled Estrogen Receptor 1 (GPER1) on the proliferation of breast cancer. The coupling of GPER1 to estrogen triggers cellular signaling pathways related to cell proliferation. Objective: Develop new therapeutic strategies against breast cancer. Method: We performed in silico studies to explore the binding mechanism of a set of G15 /G1 analogue compounds. We included a carboxyl group instead of the acetyl group from G1 to form amides with several moieties to increase affinity on GPER1. The designed ligands were submitted to

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Rock, EP, EF Jr Roth, RR Rojas-Corona, et al. "Thrombospondin mediates the cytoadherence of Plasmodium falciparum- infected red cells to vascular endothelium in shear flow conditions." Blood 71, no. 1 (1988): 71–75. http://dx.doi.org/10.1182/blood.v71.1.71.71.

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Abstract Cerebral malaria is thought to involve specific attachment of Plasmodium falciparum-infected knobby red cells to venular endothelium. The nature of surface ligands on host endothelial cells that may mediate cytoadherence is poorly understood. We have investigated the effects of soluble thrombospondin, rabbit antiserum raised against thrombospondin, and human immune serum on cytoadherence of parasitized erythrocytes in ex vivo mesocecum vasculature. Preincubation of infected red cells with soluble thrombospondin or human immune serum inhibits binding of infected red cells to rat venula

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Rock, EP, EF Jr Roth, RR Rojas-Corona, et al. "Thrombospondin mediates the cytoadherence of Plasmodium falciparum- infected red cells to vascular endothelium in shear flow conditions." Blood 71, no. 1 (1988): 71–75. http://dx.doi.org/10.1182/blood.v71.1.71.bloodjournal71171.

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Cerebral malaria is thought to involve specific attachment of Plasmodium falciparum-infected knobby red cells to venular endothelium. The nature of surface ligands on host endothelial cells that may mediate cytoadherence is poorly understood. We have investigated the effects of soluble thrombospondin, rabbit antiserum raised against thrombospondin, and human immune serum on cytoadherence of parasitized erythrocytes in ex vivo mesocecum vasculature. Preincubation of infected red cells with soluble thrombospondin or human immune serum inhibits binding of infected red cells to rat venular endothe

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Khan, Shan, Manas Paresh Patel, Aleem Damji Patni, and Sung-Jae Cha. "Targeting Plasmodium Life Cycle with Novel Parasite Ligands as Vaccine Antigens." Vaccines 12, no. 5 (2024): 484. http://dx.doi.org/10.3390/vaccines12050484.

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The WHO reported an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries in 2022. A total of 94% of malaria deaths occurred in Africa, 80% of which were children under 5. In other words, one child dies every minute from malaria. The RTS,S/AS01 malaria vaccine, which uses the Plasmodium falciparum circumsporozoite protein (CSP) to target sporozoite infection of the liver, achieved modest efficacy. The Malaria Vaccine Implementation Program (MVIP), coordinated by the WHO and completed at the end of 2023, found that immunization reduced mortality by only 13%. To further

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Telen, Marilyn J., Milena Batchvarova, Siqing Shan, et al. "Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell-induced vaso-occlusion." British Journal of Haematology 175, no. 5 (2016): 935–48. http://dx.doi.org/10.1111/bjh.14303.

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Kowalski, Szymon, Dariusz Wyrzykowski, Stanislaw Hac, Michal Rychlowski, Marek Witold Radomski, and Iwona Inkielewicz-Stepniak. "New Oxidovanadium(IV) Coordination Complex Containing 2-Methylnitrilotriacetate Ligands Induces Cell Cycle Arrest and Autophagy in Human Pancreatic Ductal Adenocarcinoma Cell Lines." International Journal of Molecular Sciences 20, no. 2 (2019): 261. http://dx.doi.org/10.3390/ijms20020261.

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Pancreatic cancer is characterized by one of the lowest five-year survival rates. In search for new treatments, some studies explored several metal complexes as potential anticancer drugs. Therefore, we investigated three newly synthesized oxidovanadium(IV) complexes with 2-methylnitrilotriacetate (bcma3−), N-(2-carbamoylethyl)iminodiacetate (ceida3−) and N-(phosphonomethyl)-iminodiacetate (pmida4−) ligands as potential anticancer compounds using pancreatic cancer cell lines. We measured: Cytotoxicity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), neutral red (NR) an

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Khmil, N. V., and V. G. Kolesnikov. "Model study of the protein-ligand binding in the development of hypersensitivity to folic acid and its analogs." Low Temperature Physics 50, no. 1 (2024): 9–14. http://dx.doi.org/10.1063/10.0023884.

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Folic acid (FA) plays a vital role in various metabolic processes, including synthesis and repair of DNA, cell division, the production of red blood cells, and fetal development. However, hypersensitivity to FA and its analogs can occur, leading to various symptomatic manifestations, including shortness of breath, skin rashes, itching, hives, swelling, gastrointestinal disturbances, tachycardia, and anaphylaxis. The mechanism of hypersensitivity to FA and its analogs is not well understood. However, it is known that human serum albumin (HSA) serves as a major pharmacokinetic effector for many

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Masson, P., MT Froment, RC Sorenson, CF Bartels, and O. Lockridge. "Mutation His322Asn in human acetylcholinesterase does not alter electrophoretic and catalytic properties of the erythrocyte enzyme." Blood 83, no. 10 (1994): 3003–5. http://dx.doi.org/10.1182/blood.v83.10.3003.3003.

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Abstract The YT blood group antigen is located on human red blood cell (RBC) acetylcholinesterase. Wild-type acetylcholinesterase, YT1, has histidine at codon 322, whereas the genetic variant of acetylcholinesterase, YT2, has asparagine. This mutation is located within exon 2 of the ACHE gene, an exon that is present in all alternatively spliced forms of acetylcholinesterase. Therefore, acetylcholinesterase in brain and muscle has the same mutation as RBC acetylcholinesterase. We compared the electrophoretic and kinetic properties of RBC acetylcholinesterases having His 322 or Asn 322. We foun

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Setty, B. N. Yamaja, Surekha Kulkarni, and Marie J. Stuart. "Role of erythrocyte phosphatidylserine in sickle red cell–endothelial adhesion." Blood 99, no. 5 (2002): 1564–71. http://dx.doi.org/10.1182/blood.v99.5.1564.

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Phosphatidlyserine (PS) exposure on the erythrocyte surface endows the cell with the propensity of adhering to vascular endothelium. Because individuals with sickle cell disease (SCD) manifest loss of erythrocyte membrane asymmetry with PS exposure, we have assessed the contribution of this marker to the process of sickle erythrocyte–microendothelial adhesion. Assays for plasma-induced adhesion were conducted on unactivated endothelium, in the absence of immobilized ligands, such that PS was compared to the erythrocyte adhesion receptor CD36. Blocking studies with erythrocytes pretreated with

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Pinheiro, Carla da S., Ana Paula T. Monteiro, Fabiano F. Dutra та ін. "Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products". Mediators of Inflammation 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2086840.

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TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participation of TLR2, TLR3, TLR4, and TLR9 in FcγR-mediated phagocytosis and whether this process is modulated by LTs. Rat alveolar macrophages (AMs), murine bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PMs) treated with TLR2, TLR3, and TLR4 agonists, but not TLR9,

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Eidelman, O., P. Yani, H. C. Englert, H. G. Lang, R. Greger, and Z. I. Cabantchik. "Macromolecular conjugates of transport inhibitors: new tools for probing topography of anion transport proteins." American Journal of Physiology-Cell Physiology 260, no. 5 (1991): C1094—C1103. http://dx.doi.org/10.1152/ajpcell.1991.260.5.c1094.

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Macromolecular-conjugated, water-soluble, membrane-impermeant compounds were designed and assessed as topological probes for chloride-transporting agencies. The novel compounds were derivatives of either disulfonic stilbene (DS) and benzylaminoethylsulfonate (BS), "classical" inhibitors of erythrocyte chloride-bicarbonate exchange, or of phenylanthranilates (PA), high-affinity blockers of epithelial chloride channels. Covalent reactive derivatives of various DS, BS, and PA were synthesized and coupled either directly to polyethylene glycol or via spacer arms of different lengths to dextrans. T

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Guchhait, Prasenjit, Perumal Thiagarajan, and Jose A. Lopez. "Cell Membrane Sulfatide Promotes Sickle Cell Adhesion to Endothelium." Blood 110, no. 11 (2007): 1722. http://dx.doi.org/10.1182/blood.v110.11.1722.1722.

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Abstract Sickle cell disease (SCD) affects millions of people worldwide, and is associated with significant morbidity and mortality. Although the clinical manifestations of the disease are very complex, much of the cause can be ascribed to occlusion of small vessels by the sickle red blood cells (RBCs). More than 30% of all deaths in SCD are due to the vasoocclusion, which results in ischemia, multiorgan failure and strokes. The proximate cause for vasoocclusion appears to be an increased adhesiveness of sickle cells to the vessel wall, and we postulate that the exposure of sulfatide on sickle

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Terpstra, Valeska, and Theo J. C. van Berkel. "Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice." Blood 95, no. 6 (2000): 2157–63. http://dx.doi.org/10.1182/blood.v95.6.2157.

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Abstract In vitro studies have shown that damaged red cells and apoptotic cells are efficiently phagocytosed by scavenger receptors from macrophages, even under non-opsonizing conditions. Damaged red blood cells are in vivo effectively removed from the blood circulation, but the responsible receptor systems are largely unknown. We used a murine model in which 51Cr-labeled oxidized red blood cells were injected intravenously, and the cellular uptake sites and the potential involvement of scavenger receptors were analyzed. The decay of damaged red cells was rapid (more than 50% removed within 10

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Ghosh, Arunima, Maria Febbraio, Keith McCrae, and Roy L. Silverstein. "Endothelial Derived Microparticles Bind and Activate Platelets in a CD36 Dependent Manner." Blood 110, no. 11 (2007): 418. http://dx.doi.org/10.1182/blood.v110.11.418.418.

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Abstract Endothelial cell (EC) derived microparticles (MP) have been identified in the circulation of patients with arterial prothrombotic tendencies such as diabetes, anti-phospholipid syndrome and acute coronary syndrome. CD36 is a Type B scavenger receptor that is expressed on many cells including megakaryocytes and platelets, where it was first identified as glycoprotein IV. It recognizes several classes of ligand including thrombospondins, oxidized LDL, and apoptotic cells, and has been shown to play a role in phagocytosis, angiogenesis and atherosclerosis. The function of CD36 on platele

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Neutra, M. R., A. Ciechanover, L. S. Owen, and H. F. Lodish. "Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis." Journal of Histochemistry & Cytochemistry 33, no. 11 (1985): 1134–44. http://dx.doi.org/10.1177/33.11.2997327.

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Proteins coupled to colloidal gold particles have been widely used to visualize the uptake and intracellular transport of specific ligands by receptor-mediated endocytosis. The intracellular route of lysosome-directed ligands such as asialoglycoproteins (ASGP) are apparently unaltered by conjugation to gold, but the pathway of transferrin, a ligand that normally recycles to the cell surface, was reported to be altered by conjugation to 15-20 nm gold. In this study, we sought to determine whether a smaller transferrin-gold probe would recycle, and whether it might enter the same endosomal and l

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Coates, Christopher J., Claire McCulloch, Joshua Betts, and Tim Whalley. "Echinochrome A Release by Red Spherule Cells Is an Iron-Withholding Strategy of Sea Urchin Innate Immunity." Journal of Innate Immunity 10, no. 2 (2017): 119–30. http://dx.doi.org/10.1159/000484722.

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Cellular immune defences in sea urchins are shared amongst the coelomocytes - a heterogeneous population of cells residing in the coelomic fluid (blood equivalent) and tissues. The most iconic coelomocyte morphotype is the red spherule cell (or amebocyte), so named due to the abundance of cytoplasmic vesicles containing the naphthoquinone pigment echinochrome A. Despite their identification over a century ago, and evidence of antiseptic properties, little progress has been made in characterising the immunocompetence of these cells. Upon exposure of red spherule cells from sea urchins, i.e., Pa

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Lynch, Will E., Clifford W. Padgett, Brandon Quillian, and John Haddock. "A square-planar hydrated cationic tetrakis(methimazole)gold(III) complex." Acta Crystallographica Section C Structural Chemistry 71, no. 4 (2015): 298–300. http://dx.doi.org/10.1107/s205322961500474x.

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The cationic pseudo-square-planar complex tetrakis(1-methyl-2,3-dihydro-1H-imidazole-2-thione-κS)gold(III) trichloride sesquihydrate, [Au(C4H6N2S)4]Cl3·1.5H2O, was isolated as dark-red crystals from the reaction of chloroauric acid trihydrate (HAuCl4·3H2O) with four equivalents of methimazole in methanol. The AuIIIatoms reside at the corners of the unit cell on an inversion center and are bound by the S atoms of four methimazole ligands in a planar arrangement, with S—Au—S bond angles of approximately 90°.

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Campos, María I. León. "Study of composition of hydrogels and bioactive zinc (II) MOFs on plant tissue growth." Mediterranean Journal of Basic and Applied Sciences 08, no. 02 (2024): 21–31. http://dx.doi.org/10.46382/mjbas.2024.8202.

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In this work, we report the synthesis of metal-organic frameworks (MOFs) using zinc (II) and the amino acids L-phenylalanine (Phe), L-tryptophan (Trp), and L-histidine (His) as ligands. They were incorporated in hydrogel matrixes comprised of collagen, starch, green and red tomato cells to obtain composite hydrogels. The cell migration into the polymer matrices, the resistance to degradation and in vitro biocompatibility of hydrogels was studied. The cell migration assay showed a high confluence of plant cells, indicating a favorable environment for cell migration and proliferation in the pres

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Lee, Yung-Kuo, Wen-Chiu Chang, Ekambaranellore Prakash, et al. "Carbohydrate Ligands for COVID-19 Spike Proteins." Viruses 14, no. 2 (2022): 330. http://dx.doi.org/10.3390/v14020330.

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An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022. Although carbohydrates have been found to play a role in coronavirus binding and infection, the role of cell surface glycans in SARS-CoV-2 infection and pathogenesis is still not understood. Herein, we report that the SARS-CoV-2 spike protein S1 subunit binds specifically to blood group A and B antigens, and that the spike protein S2 subunit has a bi

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Spiller, Fernando, Corwin M. Nycholat, Chika Kikuchi, James C. Paulson, and Matthew S. Macauley. "Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens." Journal of Immunology 200, no. 3 (2017): 949–56. http://dx.doi.org/10.4049/jimmunol.1701257.

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DeVito, Nicholas, Michael Sturdivant, Luke Wachsmuth, et al. "425 Investigation of Wnt ligand signaling regulators as a predictor of Anti-PD-1 response in metastatic melanoma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A450. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0425.

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BackgroundResponses to anti-PD-1 antibodies (aPD1) have changed the therapeutic landscape of metastatic melanoma, however predictive biomarkers of resistance are lacking. Beta-catenin pathway activation has been inversely correlated with tumor-infiltrating T lymphocytes in melanoma as well as several other solid tumors.1 However, activating mutations involving this pathway are rare, implying that the modulation of upstream Wnt ligand/Fzd receptor (Wnt/Fzd) signaling could be a critical regulator of anti-tumor immunity. Indeed, expression of certain Wnt ligands has been associated with inferior

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Bernit, Emmanuelle, Estelle Jean, Bastien Marlot, et al. "HLA-F and LILRB1 Genetic Polymorphisms Associated with Alloimmunisation in Sickle Cell Disease." International Journal of Molecular Sciences 24, no. 17 (2023): 13591. http://dx.doi.org/10.3390/ijms241713591.

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Red blood cell (RBC) transfusion remains a critical component in caring for the acute and chronic complications of sickle cell disease (SCD). Patient alloimmunisation is the main limitation of transfusion, which can worsen anaemia and lead to delayed haemolytic transfusion reaction or transfusion deadlock. Although biological risk factors have been identified for immunisation, patient alloimmunisation remains difficult to predict. We aimed to characterise genetic alloimmunisation factors to optimise the management of blood products compatible with extended antigen matching to ensure the self-s

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Glass, Karen, Ajit Singh, Mirabella Vulikh, et al. "Plasmodium falciparum Bromodomain Protein 1 (PfBDP1): A master regulator of red blood cell invasion genes." Structural Dynamics 12, no. 2_Supplement (2025): A399. https://doi.org/10.1063/4.0000705.

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Plasmodium falciparum is a unicellular protozoan parasite that is commonly known to cause malaria in humans. The symptoms of malaria associated with repeated rounds of parasite replication, egress, and invasion into the red blood cells. During the red blood cell stage of malaria infection, PfBDP1 is shown to bind at the transcriptional start sites of invasion-related genes and regulates their expression. A recent spike in malaria infections may be attributed to drug-resistance in P. falciparum, thus we need a better understanding of the parasite's life cycle to produce more effective antimalar

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Topić, Edi, Vladimir Damjanović, Katarina Pičuljan, and Mirta Rubčić. "Dinuclear Molybdenum(VI) Complexes Based on Flexible Succinyl and Adipoyl Dihydrazones." Crystals 14, no. 2 (2024): 135. http://dx.doi.org/10.3390/cryst14020135.

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A series of molybdenum(VI) complexes with aryl-functionalized alkyl dihydrazones was prepared by the reaction of [MoO2(acac)2] and the appropriate dihydrazone in methanol. Their solid-state structures were elucidated via single-crystal X-ray diffraction (SC-XRD) and Fourier-transform infra-red (FTIR) spectroscopy, while the thermal stability of compounds was inspected by combined thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) experiments. The behaviour of complexes in DMSO-d6 solution was explored by nuclear magnetic resonance (NMR). The relevant data show that al

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Ihanus, Eveliina, Liisa M. Uotila, Anne Toivanen, Minna Varis, and Carl G. Gahmberg. "Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4." Blood 109, no. 2 (2006): 802–10. http://dx.doi.org/10.1182/blood-2006-04-014878.

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Abstract Intercellular adhesion molecule 4 (ICAM-4) is a unique member of the ICAM family because of its specific expression on erythroid cells and ability to interact with several types of integrins expressed on blood and endothelial cells. The first reported receptors for ICAM-4 were CD11a/CD18 and CD11b/CD18. In contrast to these 2, the cellular ligands and the functional role of the third β2 integrin, CD11c/CD18, have not been well defined. Here, we show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of I

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Keppler-Ross, Sabine, Lois Douglas, James B. Konopka, and Neta Dean. "Recognition of Yeast by Murine Macrophages Requires Mannan but Not Glucan." Eukaryotic Cell 9, no. 11 (2010): 1776–87. http://dx.doi.org/10.1128/ec.00156-10.

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ABSTRACT The first barrier against infection by Candida albicans involves fungal recognition and destruction by phagocytic cells of the innate immune system. It is well established that interactions between different phagocyte receptors and components of the fungal cell wall trigger phagocytosis and subsequent immune responses, but the fungal ligands mediating the initial stage of recognition have not been identified. Here, we describe a novel assay for fungal recognition and uptake by macrophages which monitors this early recognition step independently of other downstream events of phagocytos

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