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Rozprawy doktorskie na temat „Regenerative Medicine Mesenchymal Stem-cells”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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Perruisseau-Carrier, Claire. "Neuronal commitment of Umbilical Cord Mesenchymal Stem Cells for brain regenerative medicine." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10192.

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De nos jours, aucune prévention ou aucun remède efficace n'existe pour guérir les maladies du cerveau humain. Les cellules souches représentent un grand espoir pour la réparation et la régénération des tissus neuraux endommagés. L'objectif de cette thèse est d'évaluer la capacité des cellules souches du cordon ombilical humain (hUC MSCs) à se différencier en neurones, pour une thérapie cellulaire appliquée au cerveau. Nous avons isolé, multiplié et caractérisé les hUC MSCs naïves à l'échelle des gènes et des protéines. Ensuite, les e_ets sur l'expansion des hUC MSCs et leur différenciation neu

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Youngstrom, Daniel W. "Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64422.

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Tendon function is essential for quality of life, yet the pathogenesis and healing of tendinopathy remains poorly understood compared to other musculoskeletal disorders. The aim of regenerative medicine is to replace traditional tissue and organ transplantation by harnessing the developmental potential of stem cells to restore structure and function to damaged tissues. The recently discovered interdependency of cell phenotype and biophysical environment has created a paradigm shift in cell biology. This dissertation introduces a dynamic in vitro model for tendon function, dysfunction and devel

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Popielarczyk, Tracee. "Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78789.

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Mesenchymal stem cells (MSCs) have great potential to improve clinical outcomes for many inflammatory and degenerative diseases through delivery of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined by microenvironmental cues, specifically dimensionality, topography, and cell-cell interactions. MSC responses of migration and differentiation are the focus of this dissertation. Cell migration occurs in several physiological and pathological processes; migration mode and cell signaling

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Miller, Angela. "Peptide based hydrogels in the study of mesenchymal stem cells for the purposes of regenerative medicine." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6880/.

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Regenerative medicine is a vastly expanding subject area, with a number of different strategies and substrates being studied to ultimately create a model for repairing diseased and injured tissue. Stem cells are a promising cell type in this field as they are known to differentiate into a number of cell types and contribute to normal cell repair. However, despite their potential as a useful cell choice in the field of regenerative medicine, stem cell based therapies have limited potential due to their ability to form tumours when implanted in the human body, problems arising with immunogenicit

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Coffin, Spencer. "Extending the Window of Use for Human Mesenchymal Stem Cell Seeded Biological Sutures." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-theses/510.

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Cell therapy, including human mesenchymal stem cell (hMSC) therapy, has the potential to treat different pathologies, including myocardial infarctions (heart attacks). Biological sutures composed of fibrin have been shown to effectively deliver hMSCs to infarcted hearts. However, hMSCs rapidly degrade fibrin making cell seeding and delivery time sensitive. To delay the degradation process, we propose using aprotinin, a proteolytic enzyme inhibitor that has been shown to slow fibrinolysis. This project investigated the effects of aprotinin on hMSCs and suture integrity. Viability of hMSCs incub

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Sheard, Jonathan. "Screening and improving the safe provision of mesenchymal stem cells in regenerative medicine : an in vitro study." Thesis, Aston University, 2016. http://publications.aston.ac.uk/30085/.

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A number of studies have suggested that mesenchymal stem cells (MSCs) may undergo genetic alterations and spontaneous malignant transformation to form tumour cells, or at least can become contaminated with other cell types following extended periods in culture. Possible transformation or contamination of MSCs during cell culture expansion prior to their use in transplantation therapies is a risk, which should be taken into account. There is a continued need for the development of improved tools for monitoring safety and release criteria of cells intended for cell-based therapies. In order to h

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Lazin, Jamie Jonas. "The effect of age and sex on the number and osteogenic differentiation potential of adipose-derived mesenchymal stem cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34696.

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It has been shown that stem cells exist within adult adipose tissue. These stem cells are named adipose-derived mesenchymal stem cells (ASCs), are derived from the mesoderm, and can differentiate into a number of cells including osteoblasts, chondrocytes, and adipocytes. However, before these cells can be used clinically it is important that we understand how factors like age, sex, and ethnicity affect ASC number and potential. Additionally, since men and women vary in their distribution of adipose tissue, it will be important to see if the ideal source of ASCs is different for each sex. The

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Chan, Alexander K. C. "Development of characterisation and quality potency assays for human mesenchymal stem cells." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/22977.

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Regenerative medicine and cell therapies hold great potential to treat a variety of medical conditions. Product characterisation of these therapies is particularly difficult as they pose regulatory challenges due to donor heterogeneity and the lack of standardised lot release tests that can reliably predict in vivo function. Human mesenchymal stem cells (hMSCs), also called multipotent stem cells or mesenchymal stromal cells, are a viable option in cell therapies due to their immunosuppressive and pro-angiogenic functions. Currently there are no standardised methods or potency assays to quanti

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Bogers, Sophie Helen. "Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/81746.

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Osteoarthritis (OA) is a degenerative disease of diarthrodial joints causing pain and loss of joint function. Etiology is heterogeneous, but commonly involves inflammation arising from impairment of normal tissue homeostasis and/or function. A cycle of low-grade inflammation and global tissue degradation causes alteration of tissue morphology and function via primary mechanisms or inability to withstand physiological forces. Current therapies variably ameliorate symptoms but do not modify progression. Mesenchymal stem cells (MSCs) have multi-modal properties but are ineffective in ameliorating

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VECCHIATINI, Renata. "Mesenchymal stem cells from Wharton's Jelly and periodontal ligament: reliable not controversial sources for osteogenic differentiation and regenerative medicine." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388818.

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Mesenchymal stem cells (MSCs) are uniquely capable of crossing germinative layers borders (these cell populations are able to differentiate towards ectoderm-, mesoderm- and endoderm- derived lineages) and are viewed as promising cells for regenerative medicine approaches in several diseases. Some undoubtedly limiting factors for the clinical use of MSCs, i.e. for the repair of bone defects, are related to many different problems, that only partially today can be overcome through ex-vivo expansion and cells modification strategies. Considering MSCs sources, the use of fetal annexes-deriv

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Gomiero, Chiara. "Novel regenerative medicine approaches with the use of adult mesenchymal stem cells: in vitro and in vivo experimental procedures." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422897.

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Tendon injuries are often associated with skeletal muscle lesions that can originate from a variety of events, including direct trauma, tendon and muscle lacerations and contusions, indirect insults and degenerative diseases as muscular dystrophies. Currently, a complete cure for musculoskeletal diseases is not present and the restitutio ad integrum is difficult to obtain. In the last decade, adult MSCs gained general attention in both human and veterinary medicine and the understanding of MSC function is improved promoting the application of cell therapy and the development of powerful cell

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Reisbig, Nathalie A. "Synovial Extracellular Matrix and Synovial Mesenchymal Stem Cells are Chondrogenic In Vitro and In Vivo." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543150403002824.

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Rafiq, Qasim Ali. "Developing a standardised manufacturing process for the clinical-scale production of human mesenchymal stem cells." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/12335.

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Human mesenchymal stem cells (hMSCs) are a promising candidate for cell-based therapies given their therapeutic potential and propensity to grow in vitro. However, to generate the cell numbers required for such applications, robust, reproducible and scalable manufacturing methods need to be developed. To address this challenge, the expansion of hMSCs in a microcarrier-based bioreactor system was investigated. Initial studies performed in T-flask monolayer cultures investigated the effect of key bioprocess parameters such as dissolved oxygen concentration (dO2), the level of medium exchange and

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Shaffer, Robyn Denise. "Complementary Strategies to Promote Mesenchymal Stem Cell Differentiation for Ligament Tissue Engineering." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/40295.

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Anterior cruciate ligament (ACL) ruptures and tears are significant orthopedic problems that result in discomfort and limited mobility. Fully functional tissue engineered ligament replacements are promising alternatives to current graft choices for repair of ACL disruptions. The cell-based approach to construct engineered ligament grafts presented herein involves the culture of mesenchymal stem cells (MSC) on biodegradable, fibrous polymeric scaffolds to promote tissue formation. Multipotent MSCs are advantageous because of their in vitro proliferative capacity and ease of harvest; however;

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Kaur, Navdeep. "Influence of culture conditions on the molecular signature of mesenchymal stem cells." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/43719/1/Navdeep_Kaur_Thesis.pdf.

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Cell based therapies require cells capable of self renewal and differentiation, and a prerequisite is the ability to prepare an effective dose of ex vivo expanded cells for autologous transplants. The in vivo identification of a source of physiologically relevant cell types suitable for cell therapies is therefore an integral part of tissue engineering. Bone marrow is the most easily accessible source of mesenchymal stem cells (MSCs), and harbours two distinct populations of adult stem cells; namely hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs). Unlike HSCs, there ar

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Corradetti, Bruna. "Mesenchymal stem cells from extra-fetal tissues in the horse: in vitro and in vivo studies for the allogenic application in regenerative medicine." Doctoral thesis, Università Politecnica delle Marche, 2012. http://hdl.handle.net/11566/242562.

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Obiettivo di questo lavoro è stato quello di mettere a punto protocolli per l’isolamento, l’espansione e la caratterizzazione in vitro di popolazioni omogenee di cellule staminali mesenchimali (MSC) isolate da tessuti extra-fetali equini (matrice cordonale e amnios), valutandone il possibile impiego nella terapia delle lesioni tendinee. Dai risultati ottenuti emerge che le popolazioni cellulari isolate sono caratterizzate dall’espressione di marker di mesenchimalità e pluripotenza, dall’assenza di espressione di marker di immunogenicità, da un’intensa capacità proliferativa e differenzi

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PISTILLO, ROSSELLA SOCCORSA. "Human chorionic villus, amniotic fluid and amniotic membrane: Three different gestational tissues as source of valuable mesenchymal stem cells for regenerative medicine applications." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/252919.

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La medicina “rigenerativa” ha come scopo quello di riparare o ripristinare la funzionalità di organi o tessuti danneggiati da malattie, traumi o dal “semplice” invecchiamento mediante l’utilizzo di cellule staminali. Una linea cellulare staminale molto importante e molto utilizzata in approcci di medicina rigenerativa è costituita dalle staminali adulte o staminali mesenchimali. Il midollo osseo e il tessuto adiposo sono stati considerati, per lungo tempo, la principale fonte di staminali mesenchimali adulte. Tuttavia le staminali adulte prevedono tecniche di prelievo invasive, non prive di co

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Haddouti, El-Mustapha [Verfasser]. "Characterization of Mesenchymal Stromal Cells for Musculoskeletal Disorders and Regenerative Medicine / El Mustapha Haddouti." Bonn : Universitäts- und Landesbibliothek Bonn, 2021. http://d-nb.info/1238687407/34.

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Menezes, Rui Miguel Van Raay Ferraz de Menezes. "Intralesional treatment with mesenchymal stem cells in horses with suspensory ligament desmitis and super cial digital exor tendonitis: a retrospective study." Master's thesis, Universidade de Évora, 2021. http://hdl.handle.net/10174/29764.

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Mesenchymal stem cells (MSCs) promote the regeneration of scarless tendon tissue after injury. Various sources have been described and used to obtain MSCs, adipose tissue and bone-marrow are one of the most used. A population of 49 horses, that suffered superficial digital flexor tendonitis or suspensory ligament desmitis and were treated either with the combination of stromal vascular fraction and platelet rich plasma, or with allogenic bone marrow derived MSCs, was analyzed retrospectively. The influence of different factors (age, breed, discipline, injury chronicity, treated structure and t

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Heathman, Thomas R. J. "Developing a process control strategy for the consistent and scalable manufacture of human mesenchymal stem cells." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/22174.

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Human mesenchymal stem cells (hMSCs) have been identified as a promising cell-based therapy candidate to treat a number of unmet clinical indications, however, in vitro expansion will be required to increase the available number of cells and meet this demand. Scalable manufacturing processes, amenable to closed, single-use and automated technology, must therefore be developed in order to produce safe, effective and affordable hMSC therapies. To address this challenge, a controlled serum-free end-to-end microcarrier process has been developed for hMSCs, which is amenable to large-scale manufact

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Doyle, Adele Marion. "Conservation of mechanosignaling: responses of human adult mesenchymal stem cells and differentiated vascular cells to applied physical forces." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39526.

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Mesenchymal stem cells (MSCs) may benefit vascular cell-based therapies as smooth muscle or endothelial cell substitutes or through paracrine actions to repair, replace, or regenerate vascular tissue. Previous studies have demonstrated that MSCs can adopt traits of smooth muscle cells (SMCs) or endothelial cells (ECs), as well as secrete specific factors that tune signaling and material properties in the local environment. Few studies have investigated the cell signaling response of MSCs to mechanical forces present in the vasculature: specifically, shear stress due to blood flow and cyclic st

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Fotticchia, Andrea. "Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21407.

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In several cases, current therapies available to treat a large number of musculoskeletal system diseases are unsatisfactory as they provide only temporary or partial restoration of the damaged or degenerated site. In an attempt to maintain a high standard of life quality and minimise the economic losses due to the treatments of these frequently occurring ailments and subsequent lost working days, alternative therapies are being explored. Contrary to the current treatments, tissue engineering aims to regenerate the impaired tissue rather than repair and alleviate the symptoms; thus offering a d

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TIMONERI, Francesca. "Wharton’s Jelly Mesenchymal Stem Cells from Preterm Umbilical Cords: Isolation, Characterization and Potential Use as Extrahepatic Progenitors." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91037.

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Alt, Daniel Scott. "PREVASCULAR CELL CONDENSATIONS FOR MODULAR TISSUE ENGINEERING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1599521079956842.

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André, Emilie. "Combination of nano and microcarriers for stem cell therapy of Huntington's disease : new regenerative medicine strategy." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0047/document.

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La combinaison de biomatériaux et cellules souches, a pour but de protéger des cellules endommagées et de ralentir la progression des maladies neurodégénératives, comme la maladie de Huntington (MH). Les cellules souches mésenchymateuses et particulièrement une sous-population, les cellules MIAMI, ont déjà démontré leur efficacité dans la maladie de Parkinson. Il est cependant essentiel d’améliorer leur différenciation neuronale, leur survie et évaluer leur sécrétome. L’objectif principal de ce travail fut de proposer une stratégie innovante de médecine régénératrice pour la MH associant cellu

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Hammoudi, Taymour Marwan. "3D micropatternable hydrogel systems to examine crosstalk effects between mesenchymal stem cells, osteoblasts, and adipocytes." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45972.

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Poor skeletal health results from aging and metabolic diseases such as obesity and diabetes and involves impaired homeostatic balance between marrow osteogenesis and adipogenesis. Tissue engineering provides researchers with the ability to generate improved, highly controlled and tailorable in vitro model systems to better understand mechanisms of homeostasis, disease, and healing and regeneration. Model systems that allow assembly of modules of MSCs, osteoblasts, and adipocytes in a number of configurations to engage in signaling crosstalk offer the potential to study integrative physiologica

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Kramm, Anneke. "Identification and characterisation of epigenetic mechanisms in osteoblast differentiation of human mesenchymal stem cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b6f7a356-b20f-4988-8770-8bebc233bf4b.

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A major therapeutic challenge in musculoskeletal regenerative medicine is how to effectively replenish bone tissue lost due to pathological conditions such as fracture, osteoporosis, or rheumatoid arthritis. Mesenchymal stem cells are currently investigated for applications in bone-tissue engineering and human bone marrow-derived mesenchymal stem cells (hMSCs) could be a promising source for generation of tissue-engineered bone. However, the therapeutic potential of MSCs has not been fully exploited due to a lack of knowledge regarding the identity, nature, and differentiation of hMSCs. Epigen

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GORGUN, CANSU. "Functional Characterization of Mesenchymal Stromal Cell- Derived Extracellular Vesicles." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1044371.

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Mesenchymal Stromal Cells (MSCs) are currently considered a powerful tool for the treatment of multiple diseases. Indeed, the original hypothesis underlying MSC based regenerative therapies was based on functional recovery as a consequence of stem cell differentiation. But it is now clear that other mechanisms of action are involved. The recent emerging paradigm shift suggests that the paracrine effects of MSCs may be as important as cell differentiation in eliciting functional tissue repair. Among the factors responsible for the paracrine effects, extracellular vesicles (EVs) have been recent

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Vivas, Pradillo Daniel. "Optimisation of a Tissue Engineering Product based on Mesenchymal Stromal Cells aiming to regenerate bony tissue." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664844.

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Bone is a highly organised and specialised connective tissue that provides a rigid, protective and supporting framework to the body. In addition to this, bone is unique in its capacity to self-regenerate without the formation of a fibrotic scar. Despite its natural healing potential, bone is not always able to repair large defects, which can result in permanent bone loss and fracture non-unions. Consequently, interventions such as bone grafting are required to replace damaged or diseased bone, accounting for more than two million grafted bones in the world annually. Currently, autografts are

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Rony, R. M. Imtiaz Karim. "Transcriptional characterization of osteogenic and adipogenic differentiation of human bone marrow derived mesenchymal stem cells in 2D and 3D peptide hydrogel culture system." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1536841298659517.

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Sanchez, Diego Noé Rodriguez [UNESP]. "Efeito do transplante de células-tronco mesenquimais multipotentes na regeneração de nervo periférico em ratos." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/139525.

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Shafiee, Abbas. "Isolation and characterisation of primitive stem cell populations from placenta." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/95086/1/Abbas_Shafiee_Thesis.pdf.

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Cardiovascular diseases (CVD) are the leading cause of death in developed societies. Vascular stem cells (VSCs) have been proposed as a cell population with regenerative potential for CVD. However, the in vivo ontogeny of VSCs remains controversial. In current study, we have isolated VSCs from the human term placenta and characterized in vivo cell populations which give rise to different stem cells. Furthermore, a novel hierarchy among vascular cells as well as their physiological localization were established. Collectively, this is an important finding for both developmental biology and cell-

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Wojtowicz, Abigail M. "Genetically-engineered bone marrow stromal cells and collagen mimetic scaffold modification for healing critically-sized bone defects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34705.

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Non-healing bone defects have a significant socioeconomic impact in the U.S. with approximately 600,000 bone grafting procedures performed annually. Autografts and allografts are clinically the most common treatments; however, autologous donor bone is in limited supply, and allografts often have poor mechanical properties. Therefore, tissue engineering and regenerative medicine strategies are being developed to address issues with clinical bone grafting. The overall objective of this work was to develop bone tissue engineering strategies that enhance healing of orthotopic defects by targeti

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Simonato, Enea. "Studio in vitro e in vivo di cellule mesenchimali da sangue cordonale e cellule satellite da fibre muscolari scheletriche nella rigenerazione muscolare." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425210.

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Previous works showed that muscle substitutes composed by acellular matrix and myoblasts may represent a promising approach for the treatment of diseases characterized by congenital absence or loss of large areas of skeletal muscle tissue. Here, the regeneration process occurring in vivo within the prosthetic material has been studied verifying the expression, as mRNA and protein, of some skeletal muscle and nerve tissue markers during three month after reconstructive surgery. The experimental evidences indicate that a progressive muscle remodelling within the implants exists and it is not c

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Boopathy, Archana Vidya. "Engineering stem cell responses using oxidative stress and notch ligand containing hydrogels." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51837.

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Heart failure is the leading cause of death worldwide. In 2013, the American Heart Association estimated that one American will die of cardiovascular disease every 39 seconds. While heart transplantation is the most viable treatment option, the limited availability of donor hearts has necessitated the search for treatment alternatives such as the use of adult stem cells for cardiac repair and regeneration. Following myocardial infarction (MI), the inflammatory cardiac microenvironment, limited survival of stem/progenitor cells, myocardial scarring and fibrosis affect cardiac regeneration. Thi

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Sá, Patrícia Amorim de. "Utilização de engenharia de tecidos no tratamento de feridas crônicas." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5147.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A pele é o maior órgão do corpo humano sendo também o órgão mais suscetível de lesões que permitem a limitação da qualidade de vida de um paciente, pelo que as feridas crônicas são cada vez mais presenciadas. Para combater esta consequência surgiu a engenharia de tecidos que permite a implantação de substitutos cutâneos semelhantes à pele humana, através do desenvolvimento de suportes que são denominados por scaffolds que podem s

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Bertoni, Lélia. "Évaluation du potentiel thérapeutique des cellules souches mésenchymateuses dans un modèle d'arthropathie expérimentale induite chez le cheval Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1 Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization Evaluation of allogeneic bone-marrow-derived and umbilical cord blood-derived mesenchymal stem cells to prevent the development of osteoarthritis in an equine model Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC417.

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’arthropathie dégénérative est une maladie ayant des répercussions socio-économiques majeures chez l’homme et le cheval. Il n’existe pour l’heure aucun traitement curatif de cette maladie, le cartilage articulaire étant dépourvu de pouvoir de cicatrisation spontané. De nombreux espoirs reposent sur l’utilisation de cellules souches mésenchymateuses (CSM), pour leur potentiel pro-régénératif et anti-inflammatoire. Le premier objectif de cette étude était d’évaluer la tolérance des CSM de sang de cordon ombilical (SCO) et de moelle osseuse (MO) dans des articulations saines. L’étude contrôlée en

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SERRA, FRANCESCA GIULIA. "Bone-like inducing grafts: in vivo and micro-CT analysis." Doctoral thesis, Politecnico di Torino, 2020. http://hdl.handle.net/11583/2858349.

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Dostert, Gabriel. "Les nanovésicules extracellulaires sécrétées par les CSMs et les nanovésicules de synthèse issues d’agro-ressources : de leur caractérisation à leur utilisation en ingénierie tissulaire." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0097/document.

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Les vésicules extracellulaires nanométriques (nEVs) issues de cellules souches mésenchymateuses (CSMs) et les nanovésicules synthétiques sont au centre de nombreuses recherches pour le développement de nouvelles stratégies thérapeutiques en médecine régénérative. La mise en place d’une méthode standardisée pour isoler les nEVs à partir de milieu conditionné de CSMs et de pouvoir les caractériser a été nécessaire. Nous nous sommes concentrés sur leur taille qui se situe entre 30 et 150 nm ainsi que la présence de certains de leur marqueurs membranaires (CD9, CD63 et CD81). Durant ce travail, de

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Gittens, Ibacache Rolando Arturo. "The role of nanostructural and electrical surface properties on the osteogenic potential of titanium implants." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45975.

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Dental and orthopaedic implants are currently the solutions of choice for teeth and joint replacements with success rates continually improving, but they still have undesirable failure rates in patients who are compromised by disease or age, and who in many cases are the ones most in need. The success of titanium (Ti) implants depends on their ability to osseointegrate with the surrounding bone and this, in turn, is greatly dependent on the surface characteristics of the device. Advancements in surface analysis and surface modification techniques have improved the biological performance of met

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Hayer, Benoît d'. "Étude des propriétés physiques et mécaniques de microsphères d'alginate au cours d'un cycle de congélation-décongélation et application pour la cryoconservation de cellules souches mésenchymateuses encapsulées." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB015.

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La thérapie cellulaire et les médicaments de thérapie innovante sont des solutions prometteuses pour la régénération des tissus ou organes présentant des défauts fonctionnels ou organiques. Avant le stade de l'insuffisance cardiaque terminale (stade IV NYHA) suite à un infarctus du myocarde, l'implantation d'un patch de fibrine cellularisé avec des progéniteurs myocardiques sur le site de nécrose de l'infarctus, est l'une des perspectives qui permettrait de régénérer un muscle cardiaque fonctionnel et apparait comme étant une alternative nouvelle avec notamment un essai clinique de phase I en

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Veyssiere, Alexis. "De la décellularisation de cartilage de porc à la chondrogenèse auriculaire." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC408.

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Les reconstructions auriculaires représentent un réel défi pour le chirurgien. Plusieurs techniques existent présentant chacune des inconvénients non négligeables.L’essor de l’ingénierie tissulaire des 20 dernières années ouvre la possibilité à de nouvelles thérapeutiques.L’ingénierie du cartilage ne déroge pas à la règle et connaît une sérieuse évolution, concernant le cartilage articulaire mais également les autres types de cartilages dont le cartilage auriculaire.Appliquées à la reconstruction auriculaire, ces techniques apportent du tissu cartilagineux tout en minorant les effets secondair

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Mandoli, Amit. "Stem cells in molecular and regenerative medicine." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3421742.

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Stem Cells are rare cells with the crucial ability to self-renew and to generate mature cells of any tissue through differentiation. Adult stem cells hold great promise for regenerative medicine, tissue repair, and gene therapy. Adult bone marrow cells (BMCs) include two populations of bone marrow stem cells (BMCs): hematopoietic stem cells (HSCs), which give rise to all mature lineages of blood, and mesenchymal stem cells (MSCs), which can differentiate into osteoblasts, chondrocytes, adipocytes, myocytes, tenocytes, and haematopoiesis supporting stromal cells. Under normal condition these st

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Prasongchean, W. "Somatic stem cells : properties and potential for regenerative medicine." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1336076/.

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Stem cells play fundamental roles in embryonic development, tissue homeostasis and have great potential in regenerative medicine. The main aims of this study were: i) to elucidate the properties and neural differentiation potential of somatic stem cells from different sources focusing on the analysis of stem cells with low immunogenicity and/or suitable for autologous cell therapy, amniotic fluid (AFSC) and adipose tissue-derived stem cells (ADSC), respectively; ii) to investigate a putative neural stem/progenitor cell niche in the choroid plexus (CP), organ that plays crucial roles in cerebro

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Halchuk, K. L. "Third molars as a source of mesenchymal stem cells and their regenerative potential." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19121.

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Wong, J. W. "Centrifugal recovery of embryonic stem cells for regenerative medicine bioprocessing." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/16358/.

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In order to realise the potential of embryonic stem (ES) cells as a regenerative medicine, it is crucial that economical, robust and scalable bioprocesses be established. Because bioprocesses irrevocably define the safety and efficacy of any biologically derived product, an understanding of the the impact of the engineering environment on ES cells is sought. This thesis uses murine ES cells as a mimic for ES cell types that will be used in cell based regenerative medicine applications to examine the bioprocessing impact of centrifugal recovery cells. A micro scale-down approach was used to exa

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Chu, Pui Kei Carol. "The bioprocessing of stem cells for use in regenerative medicine." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17422/.

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Stem cells hold great therapeutic potential in regenerative medicine due to their self-renewal capacity and their ability to differentiate into a wide range of cell lineages. This thesis is focused on the characterisation of both a pluripotent and a more specialised multipotent stem cell source. These studies involve the optimisation of essential parameters for cell expansion and differentiation. Initially, human mesenchymal stem cells (hMSCs) were used as a model system for cell expansion studies. This was followed by more advanced studies using mouse embryonic stem cells (mESC). The results

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Alanazi, Asma. "Studies of recruitment and migration of mesenchymal stem cells." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7112/.

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Mesenchymal stem cells (MSC) are used in therapy by injection into the blood. Adhesion and migration from flowing blood may be critical steps for their recruitment in the microvasculature. We aimed to understand how MSC from different sources might 'home' to injured tissue. MSC from Wharton’s jelly(WJMSC), bone marrow(BMMSC) or trabecular bone(TBMSC) were suspended in culture medium or added to whole blood, and perfused through capillaries coated with matrix proteins (collagen or fibronectin)or P- or E-selectin. Initial comparisons showed that none of the isolated MSC adhered to selectins even

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Blasimme, A. "REGENERATIVE MEDICINE AND THE GOVERNANCE OF STEM CELL INNOVATION." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/214610.

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The aim of this dissertation is to reconstruct analytically and to assess normatively the emerging governance of stem cell clinical translation. I show that the therapeutic promise of stem cell medicine is potentially revolutionary, and that its fulfilment depends on variables that are at the same time scientific and political. The establishment of the governance of stem cell translational research is however taking intricate routes. It is being contested and challenged in many ways by different actors and, most importantly, its development is yet in the making and, hence, uncertain. In this d

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Sutha, Ken. "Osteoinductive material derived from differentiating embryonic stem cells." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/51722.

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The loss of regenerative capacity of bone, from fetal to adult to aged animals, has been attributed not only to a decline in the function of cells involved in bone formation but also to alterations in the bone microenvironment that occur through development and aging, including extracellular matrix (ECM) composition and growth/trophic factor content. In the development of novel treatments for bone repair, one potential therapeutic goal is the restoration of a more regenerative microenvironment, as found during embryonic development. One approach to creating such a microenvironment is through t

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