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Artykuły w czasopismach na temat „REM dependent obstructive sleep apnea”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Lee, Seung Cheol, Doh-Eui Kim, Young Hwangbo, Mei Ling Song, Kwang Ik Yang, and Yong Won Cho. "Does REM Sleep-Dependent Obstructive Sleep Apnea Have Clinical Significance?" International Journal of Environmental Research and Public Health 19, no. 21 (2022): 14147. http://dx.doi.org/10.3390/ijerph192114147.

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(1) Background: The clinical significance of rapid eye movement (REM) sleep-dependent obstructive sleep apnea (OSA) remains controversial because various criteria have been used to describe it. This study determined the clinical significance of REM-OSA in Koreans using data from patients with sufficient total sleep time (TST) and REM sleep duration. (2) Methods: We investigated 1824 patients with OSA who were diagnosed by polysomnography (PSG). REM-OSA was defined as an overall apnea–hypopnea index (AHI) ≥ 5, NREM-AHI < 15, and REM-AHI/NREM-AHI ≥ 2. Demographic and medical data were collect

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Ece, Yazla, Bilici Mustafa, and Pelin Zerrin. "Dream Anxiety in Patients with Rapid Eye Movement Dependent Obstructive Sleep Apnea Syndrome." International Neuropsychiatric Disease Journal 9, no. 3 (2017): 1–9. https://doi.org/10.9734/INDJ/2017/33703.

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<strong>Aims:</strong> The aim of this study is to investigate the effect of the breathing disorders that arise during sleep and are predominantly observed in Rapid Eye Movement (REM) phase onto the dreams which have negative effects on daily life. While doing this, we also investigated differences between the REM dependent and non REM dependent obstructive sleep apnea syndrome groups in terms of some sociodemographic and clinical characteristics. <strong>Methods: </strong>Seventy patients who had got the diagnosis of obstructive sleep apnea syndrome (OSAS) according to American Academy of Sle

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3

Padia, Hiral, and Q. Afifa Shamim-Uzzaman. "1018 Finally Awake: Treatment of Severe REM-Isolated Obstructive Sleep Apnea." SLEEP 46, Supplement_1 (2023): A447—A448. http://dx.doi.org/10.1093/sleep/zsad077.1018.

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Abstract Introduction Obstructive sleep apnea (OSA) is typically treated with positive airway pressure (PAP) therapy in symptomatic patients with ≥ 5 obstructive respiratory events (apneas, hypopneas or respiratory effort related arousals) per hour of sleep. In this case, we present a patient with severe OSA isolated to REM sleep who demonstrated significant symptomatic improvement on PAP therapy, despite an overall apnea-hypopnea index (AHI) of less than 5 events/hour. Report of case(s) A 73-year-old obese male with history of SVT, hypertension, and diabetes presented with symptoms of snoring

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Rosa, Cintia Felicio Adriano, Marcela Souza Boldt, João Guilherme Borgio, et al. "0530 Rem-dependent Obstructive Sleep Apnea: Prevalence, Associated Comorbidities and Polysomnographic Characteristics." SLEEP 47, Supplement_1 (2024): A227. http://dx.doi.org/10.1093/sleep/zsae067.0530.

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Abstract Introduction Obstructive Sleep Apnea (OSA) in the REM phase is a phenotype whose prevalence varies between 10% and 36% of patients with OSA, it is more common in women, especially those under 55 years of age. Characterized by muscle relaxation, sympathetic activation, hypoxemia and sleep deprivation, this type of OSA can increase metabolic and cardiovascular risks. This study seeks to understand, through a large population sample, how gender influences REM OSA and its relationships with other comorbidities and risk factors. Methods The study performed a retrospective epidemiological a

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5

Bonsignore, Maria R., Emilia Mazzuca, Pierpaolo Baiamonte, Bernard Bouckaert, Wim Verbeke, and Dirk A. Pevernagie. "REM sleep obstructive sleep apnoea." European Respiratory Review 33, no. 171 (2024): 230166. http://dx.doi.org/10.1183/16000617.0166-2023.

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Obstructive sleep apnoea (OSA) can occur in both rapid eye movement (REM) and non-REM sleep or be limited to REM sleep, when the upper airway is most prone to collapse due to REM sleep atonia. Respiratory events are usually longer and more desaturating in REM than in NREM sleep. The prevalence of REM OSA is higher in women than in men and REM OSA usually occurs in the context of mild–moderate OSA based on the apnoea–hypopnoea index calculated for the entire sleep study. Studies have highlighted some detrimental consequences of REM OSA; for example, its frequent association with systemic hypert

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6

Ludwig, Katharina, Sebastian Malatantis-Ewert, Tilman Huppertz, et al. "Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study." Biology 12, no. 2 (2023): 298. http://dx.doi.org/10.3390/biology12020298.

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Patients with sleep-disordered breathing show a combination of different respiratory events (central, obstructive, mixed), with one type being predominant. We observed a reduced prevalence of central apneic events (CAEs) during REM sleep compared to NREM sleep in patients with predominant obstructive sleep apnea (OSA). The aim of this retrospective, exploratory study was to describe this finding and to suggest pathophysiological explanations. The polysomnography (PSG) data of 141 OSA patients were assessed for the prevalence of CAEs during REM and NREM sleep. On the basis of the apnea–hypopnea

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7

Moon, Hye-Jin, Sang-Hun Lim, Do Hyung Kim, Dong Eun Kim, Sang Hee Hwang, and Yong Won Cho. "Clinical Characteristics of REM-Dependent Obstructive Sleep Apnea in Korean Adults." Journal of the Korean Neurological Association 34, no. 2 (2016): 124–29. http://dx.doi.org/10.17340/jkna.2016.2.6.

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Kang, Yu-Jin, and Su-Hyun Han. "Nightmare Distress and Dream Recall in Patients With Obstructive Sleep Apnea." Journal of Sleep Medicine 20, no. 3 (2023): 169–74. http://dx.doi.org/10.13078/jsm.230022.

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Objectives: We aimed to examine dream recall and nightmare distress in patients with obstructive sleep apnea (OSA), and identify the associating factors.Methods: This cross-sectional study retrospectively enrolled adult participants (age ≥18 years) with newly diagnosed OSA that was confirmed by full-night polysomnography between 2016 and 2022. Dreaming components were assessed using a nine-item dreaming questionnaire (nightmare distress and dream recall). We compared the clinical and polysomnographic findings according to OSA severity and the presence of rapid eye movement (REM)-dependent OSA.

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9

Ozcan, Kursat Murat, Muge Ozcan, Fatih Ozdogan, Omer Hizli, Huseyin Dere, and Adnan Unal. "The predictive value of Muller maneuver in REM-dependent obstructive sleep apnea." European Archives of Oto-Rhino-Laryngology 270, no. 10 (2013): 2759–62. http://dx.doi.org/10.1007/s00405-013-2509-x.

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Cunningham, Tony, Divya Kishore, Mengshuang Guo, et al. "049 The Effect of Obstructive Sleep Apnea on Emotional Memory Consolidation." Sleep 44, Supplement_2 (2021): A21. http://dx.doi.org/10.1093/sleep/zsab072.048.

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Abstract Introduction A growing body of evidence suggests that sleep is critical for the processing and consolidation of emotional information into long-term memory. Previous research has indicated that emotional components of scenes particularly benefit from sleep in healthy groups, yet sleep dependent emotional memory processes remain unexplored in many clinical cohorts, including those with obstructive sleep apnea (OSA). Methods In this study, a group of newly diagnosed OSA patients (n=26) and a matched group of healthy controls (n=24) encoded scenes with negative or neutral foreground obje

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11

Schecter, Scott, and Junjie Liu. "411 REM predominance of OSA: Associated with supine position, but not with CPAP adherence." Sleep 44, Supplement_2 (2021): A163. http://dx.doi.org/10.1093/sleep/zsab072.410.

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Abstract Introduction Obstructive sleep apnea (OSA) is a heterogeneous disease dependent on many factors including the sleep stage and the body position. OSA is often more severe during the rapid eye movement (REM) sleep stage, a phenomenon known as REM predominance. Prior studies suggested associations of higher REM predominance of OSA with younger age, higher obesity, and lower adherence to continuous positive airway pressure (CPAP) therapy, but these studies had small cohort sizes. Here we leverage home-based sleep tests (HST) that estimate REM sleep and measure body position to study REM p

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12

Soca, Rodolfo, Erica Buchner, and Hrayr Attarian. "Continuous positive airway pressure in patients with rapid eye movement (REM)-specific obstructive sleep apnea, a retrospective match-controlled chart review." F1000Research 7 (November 26, 2018): 1848. http://dx.doi.org/10.12688/f1000research.16688.1.

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Background: Rapid eye movement (REM) obstructive sleep apnea (OSA) represents 13 to 35% of all OSA cases and is more common in women. Continuous positive airway pressure (CPAP) is the gold standard for treatment of all forms of OSA but we do not know if patients with REM OSA have different pressure requirements than those with non-stage dependent OSA. Methods: This was a retrospective case control study. We first identified individuals with REM OSA and then tried to identify apnea hypopnea index (AHI), gender, and body mass index (BMI) matching controls that had non-stage specific OSA. Individ

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Soca, Rodolfo, Erica Buchner, and Hrayr Attarian. "Continuous positive airway pressure in patients with rapid eye movement (REM)-specific obstructive sleep apnea, a retrospective match-controlled chart review." F1000Research 7 (December 13, 2019): 1848. http://dx.doi.org/10.12688/f1000research.16688.2.

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Background: Rapid eye movement (REM) obstructive sleep apnea (OSA) represents 13 to 35% of all OSA cases and is more common in women. Continuous positive airway pressure (CPAP) is the gold standard for treatment of all forms of OSA but we do not know if patients with REM OSA have different pressure requirements than those with non-stage dependent OSA. Methods: This was a retrospective case control study. We first identified individuals with REM OSA and then tried to identify apnea hypopnea index (AHI), gender, and body mass index (BMI) matching controls that had non-stage specific OSA. Individ

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14

McCall, Catherine A., and Nathaniel F. Watson. "A Narrative Review of the Association between Post-Traumatic Stress Disorder and Obstructive Sleep Apnea." Journal of Clinical Medicine 11, no. 2 (2022): 415. http://dx.doi.org/10.3390/jcm11020415.

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Obstructive sleep apnea (OSA) and post-traumatic stress disorder (PTSD) are often co-morbid with implications for disease severity and treatment outcomes. OSA prevalence is higher in PTSD sufferers than in the general population, with a likely bidirectional effect of the two illnesses. There is substantial evidence to support the role that disturbed sleep may play in the pathophysiology of PTSD. Sleep disturbance associated with OSA may interfere with normal rapid eye movement (REM) functioning and thus worsen nightmares and sleep-related movements. Conversely, hyperarousal and hypervigilance

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15

Bahr-Hamm, Katharina, Nabin Koirala, Marsha Hanif, Haralampos Gouveris, and Muthuraman Muthuraman. "Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea." International Journal of Molecular Sciences 24, no. 1 (2022): 47. http://dx.doi.org/10.3390/ijms24010047.

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Intensity of respiratory cortical arousals (RCA) is a pathophysiologic trait in obstructive sleep apnea (OSA) patients. We investigated the brain oscillatory features related to respiratory arousals in moderate and severe OSA. Raw electroencephalography (EEG) data recorded during polysomnography (PSG) of 102 OSA patients (32 females, mean age 51.6 ± 12 years) were retrospectively analyzed. Among all patients, 47 had moderate (respiratory distress index, RDI = 15–30/h) and 55 had severe (RDI > 30/h) OSA. Twenty RCA per sleep stage in each patient were randomly selected and a total of 10131 R

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Ramaniuk, Aliaksandr, Semiramis Carbajal-Mamani, Susheela Hadigal, and Basma Ricaurte. "850 REM Sleep and ST Deviation in Acute Myocardial Infarction." Sleep 44, Supplement_2 (2021): A330—A331. http://dx.doi.org/10.1093/sleep/zsab072.847.

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Abstract Introduction Sleep stage architecture and amount of REM sleep have been associated with mortality and clinical recovery, without clear etiology. Patients recovering from critical illness frequently experience sleep disturbances, episodic arrhythmogenesis, EKG changes. This case aims to add to current field of study and describes an unusual pattern of sleep stage dependent, hypoxia independent, ST segment variation, which may benefit from further exploration and utilization of polysmongoraphy (PSG) in the immediate post acute MI period. Report of case(s) 46 year old female with history

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Naji, Mohsen, Maxim Komarov, Giri P. Krishnan, et al. "Computational model of brain-stem circuit for state-dependent control of hypoglossal motoneurons." Journal of Neurophysiology 120, no. 1 (2018): 296–305. http://dx.doi.org/10.1152/jn.00728.2017.

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In patients with obstructive sleep apnea (OSA), the pharyngeal muscles become relaxed during sleep, which leads to a partial or complete closure of upper airway. Experimental studies suggest that withdrawal of noradrenergic and serotonergic drives importantly contributes to depression of hypoglossal motoneurons and, therefore, may contribute to OSA pathophysiology; however, specific cellular and synaptic mechanisms remain unknown. In this new study, we developed a biophysical network model to test the hypothesis that, to explain experimental observations, the neuronal network for monoaminergic

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Erdemir Isik, Merda, Banu Eris Gulbay, Turan Acican, Fatma Ciftci, and Baris Bulut. "Comparison of REM-Dependent Obstructive Sleep Apnea (OSA) Patients with NREM-Dependent OSA Patients: Clinical and Polysomnographic Differences." Turkish Thoracic Journal 20, no. -1 (2019): 140. http://dx.doi.org/10.5152/turkthoracj.2019.140.

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Abraham, Stanley, Madeleine Basist, Sean Duenas, et al. "0499 Relationship Between RDW and Disease Burden in Obstructive Sleep Apnea." SLEEP 47, Supplement_1 (2024): A214—A215. http://dx.doi.org/10.1093/sleep/zsae067.0499.

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Abstract Introduction Obstructive sleep apnea (OSA) has significant physiologic consequences. The Apnea-Hypopnea Index (AHI) is used to define severity, but AHI only reflects the rate of sleep-disordered breathing events and does not correlate well with clinical outcomes that arise from hypoxia. Percentage of cumulative time with oxygen saturation below 90% (T90) and hypoxic burden (HBI) more accurately reflect nocturnal hypoxia and may be more suitable correlates to morbidity associated with sleep apnea. Rising Red Cell Distribution Width (RDW) reflects dysregulation in erythrocyte homeostasi

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Amorim, Mateus, Xin Wang, O. Aung, et al. "0040 Leptin Signaling in the Dorsomedial Hypothalamus Couples Metabolism and Breathing in Obesity." SLEEP 46, Supplement_1 (2023): A18—A19. http://dx.doi.org/10.1093/sleep/zsad077.0040.

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Abstract Introduction Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation to match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of the upper airway during sleep, is present in 90% of OHS patients. Leptin, an adipocyte-produced hormone, acts in leptin receptor (LEPRb) positive neurons and was implicated in the pathophysiology of OSA and OHS. Diet-induced obese (DIO) C57BL/6J mice shows features of OHS and OSA. Leptin-mediated neural pathways may link metabolism and breathing in obesity. We hypothesized that LEPRb-p

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Mazeika, Gandis, Yeilim Cho, Jack Anderson, et al. "0753 Relationship Between OSA and Sleep Biomarker Based Neurodegenerative Disorder Risk in a Clinical Cohort." SLEEP 47, Supplement_1 (2024): A322—A323. http://dx.doi.org/10.1093/sleep/zsae067.0753.

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Abstract Introduction In this pilot study, sleep biomarker-based neurodegenerative disorder (NDD) risk was assessed in a clinical cohort of patients diagnosed with varying severity of obstructive sleep apnea (OSA). Methods Consecutive in-home multi-night Sleep Profiler records from a community sleep clinic were screened for age &gt;54 years old. Cases with comorbid restless leg syndrome, hypersomnia, missing apnea-hypopnea indexes (AHI), AHI&lt; 5 or single-night recordings were excluded. The 67 remaining records were 40% female, ages 63 + 7.4 years and up to 84 years old. NDD risk was

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Kam, Korey, Jonathan Jun, Omonigho Bubu, et al. "0275 Effect of acutely induced severe OSA on AD plasma biomarkers." Sleep 45, Supplement_1 (2022): A124. http://dx.doi.org/10.1093/sleep/zsac079.273.

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Abstract Introduction Obstructive sleep apnea (OSA) has been associated with Alzheimer’s disease (AD) progression but a causal relationship is unclear. We hypothesized that OSA can influence (AD) biomarkers including beta-amyloid (Aβ) and tau, as well as neural filament light chain (NfL). Methods To test this hypothesis, we examined plasma tau, NfL, Aβ42, and Aβ40 in a randomized crossover study of OSA vs. 3-night CPAP withdrawal in 30 subjects with severe OSA adherent to CPAP. We compared the overnight change in evening to morning plasma samples across the untreated night (off) versus CPAP tr

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Lee, Ian, and Anahid Hekmat. "1008 Excessive daytime sleepiness in myotonic dystrophy treated with modafinil." SLEEP 46, Supplement_1 (2023): A443—A444. http://dx.doi.org/10.1093/sleep/zsad077.1008.

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Abstract Introduction Physiology of excessive daytime sleepiness (EDS) in myotonic dystrophy type 1 (DM1) remains incompletely understood and best practice treatment approaches are unclear. Report of case(s) We present a 73-year-old man with atrial fibrillation, implantable cardioverter defibrillator for inducible ventricular tachycardia, hypertension, and severe obstructive sleep apnea (OSA) was referred after a recent diagnosis of myotonic dystrophy type 1 (DM1) for EDS. He presented with foot pain, balance issues, and falls. A subdural hemorrhage from a fall prompted thorough evaluation inc

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Reis, Leonardo Frasson, Kelly Xu, Irma Rukhadze, and Victor Fenik. "0038 Genioglossus muscle (GG) activity evoked by pharmacological stimulation of alpha1-adrenoceptors in pre-hypoglossal region (PHR)." SLEEP 46, Supplement_1 (2023): A18. http://dx.doi.org/10.1093/sleep/zsad077.0038.

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Abstract Introduction The sleep-related withdrawal of noradrenergic excitation and increased cholinergic inhibition of hypoglossal motoneurons (HM), which control the tone of the GG, the largest protruder muscle of the tongue, play a critical role in obstructive sleep apnea pathophysiology. In an animal model of REM sleep, antagonism of alpha1 noradrenergic signaling by microinjections of prazosin into the hypoglossal nucleus (HN) strongly decreased hypoglossal nerve activity. However, a significant delay of this decrease prompted a hypothesis that prazosin must diffuse outside the HN to block

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Severiche-Bueno, Diego Fernando, and María Angelica Bazurto Zapata. "Apnea obstructiva del sueño en REM y su relevancia clínica." Revista Colombiana de Neumología 37, no. 1 (2025): 26–37. https://doi.org/10.30789/rcneumologia.v37.n1.2025.758.

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Introduction. Sleep apnea in REM is an entity that occurs in a subgroup of patients with obstructive sleep apnea, which has generated interest in recent years. Although it is a condition that has been described for several years, it is only now that its differences concerning obstructive sleep apnea have begun to be investigated. This is how we have sought to establish the function of REM sleep and determine its associations with relevant clinical scenarios in daily practice, such as daytime sleepiness and cardiovascular disease. This article reviews the importance of REM sleep and describes t

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Basner, R. C., E. Onal, D. W. Carley, E. J. Stepanski, and M. Lopata. "Effect of induced transient arousal on obstructive apnea duration." Journal of Applied Physiology 78, no. 4 (1995): 1469–76. http://dx.doi.org/10.1152/jappl.1995.78.4.1469.

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Six untreated male patients (age 19–55 yr) with obstructive sleep apnea underwent nocturnal polysomnography with acoustic stimulation to determine the effect of transient arousal on obstructive apneas during sleep. Binaural tone bursts (25–95 dB) were delivered in late expiration during the second obstructive apnea of a cycle consisting of four consecutive apneas. For the group, stimulated apneas were significantly shorter (P < 0.05, Fisher's protected least significant difference test) than were the unstimulated apneas when transient electrocortical arousal was elicited in both non-rapid-e

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Yakovlev, A. V., S. N. Shilov, N. F. Yakovleva, et al. "PROGNOSTIC ROLE OF BREATHING PARAMETERS IN THE DEVELOPMENT OF ARRHYTHMIAS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND CHRONIC HEART FAILURE." Sibirskij medicinskij vestnik 6, no. 3 (2022): 35–42. http://dx.doi.org/10.31549/2541-8289-2022-6-3-35-42.

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Abstract. Obstructive sleep apnea syndrome (OSAS) is increasingly being considered as a factor associated with the development of nocturnal arrhythmias, as well as an increased risk of sudden cardiac death. The prevalence of OSA reaches 5-7% in the adult population. The prognostic role of pathological breathing patterns has not been sufficiently investigated, and therefore further study of the pathogenesis of arrhythmias for the subsequent intensification of therapeutic measures is promising. Aim of the Research. To study the prognostic significance of individual breathing parameters in differ

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Stoohs, R., and C. Guilleminault. "Cardiovascular changes associated with obstructive sleep apnea syndrome." Journal of Applied Physiology 72, no. 2 (1992): 583–89. http://dx.doi.org/10.1152/jappl.1992.72.2.583.

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Five men free of lung or cardiovascular diseases and with severe obstructive sleep apnea participated in a study on the impact of sleep states on cardiovascular variables during sleep apneas. A total of 128 obstructive apneas [72 from stage 2 non-rapid-eye-movement (NREM) sleep and 56 from rapid-eye-movement (REM) sleep] were analyzed. Each apnea was comprised of an obstructive period (OP) followed by a hyperventilation period, which was normally associated with an arousal. Heart rate (HR), stroke volume (SV), cardiac output (CO) (determined with an electrical impedance system), radial artery

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Yakovlev, A. V., S. D. Mayanskaya, S. N. Shilov, A. T. Teplyakov, I. V. Shirinsky, and N. F. Yakovleva. "Predictive value of respiratory parameters in patients with obstructive sleep apnea and chronic heart failure with preserved ejection fraction." Kazan medical journal 101, no. 5 (2020): 652–60. http://dx.doi.org/10.17816/kmj2020-652.

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Aim. To study individual functional parameters of respiration in different phases of sleep in patients with obstructive sleep apnea (OSA) and chronic heart failure with preserved ejection fraction (HFpEF) and to assess their effect on the clinical course of the disease. Methods. The study included 86 men with OSA [with an apnea-hypopnea index (AHI) 15 per hour]. Upon inclusion in the study, all patients underwent a polysomnographic study and echocardiography, the level of brain natriuretic peptide (NT-proBNP) was determined, a six-minute walk test was performed. After 12 months of prospe

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Balcan, Baran, Yeliz Celik, Jennifer Newitt, Patrick J. Strollo, and Yüksel Peker. "REM-Predominant Obstructive Sleep Apnea in Patients with Coronary Artery Disease." Journal of Clinical Medicine 11, no. 15 (2022): 4402. http://dx.doi.org/10.3390/jcm11154402.

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Obstructive sleep apnea (OSA) is common in adults with coronary artery disease (CAD). OSA that occurs predominantly during rapid-eye movement (REM) sleep has been identified as a specific phenotype (REM-predominant OSA) in sleep clinic cohorts. We aimed to examine the association of REM-predominant OSA with excessive sleepiness, functional outcomes, mood, and quality of life in a CAD cohort, of whom 286 OSA patients with total sleep time ≥ 240 min, and REM sleep ≥ 30 min, were included. REM-predominant OSA was defined as a REM-apnea-hypopnea-index (AHI) /non-REM (NREM) AHI ≥ 2. In all, 73 (25.

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Aurora, R. Nisha, Ciprian Crainiceanu, Daniel J. Gottlieb, Ji Soo Kim, and Naresh M. Punjabi. "Obstructive Sleep Apnea during REM Sleep and Cardiovascular Disease." American Journal of Respiratory and Critical Care Medicine 197, no. 5 (2018): 653–60. http://dx.doi.org/10.1164/rccm.201706-1112oc.

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Mokhlesi, Babak, and Andrew W. Varga. "Obstructive Sleep Apnea and Cardiovascular Disease. REM Sleep Matters!" American Journal of Respiratory and Critical Care Medicine 197, no. 5 (2018): 554–56. http://dx.doi.org/10.1164/rccm.201710-2147ed.

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Davis, Eric M., Landon W. Locke, Angela L. McDowell, Patrick J. Strollo, and Christopher P. O'Donnell. "Obesity accentuates circadian variability in breathing during sleep in mice but does not predispose to apnea." Journal of Applied Physiology 115, no. 4 (2013): 474–82. http://dx.doi.org/10.1152/japplphysiol.00330.2013.

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Obesity is a primary risk factor for the development of obstructive sleep apnea in humans, but the impact of obesity on central sleep apnea is less clear. Given the comorbidities associated with obesity in humans, we developed techniques for long-term recording of diaphragmatic EMG activity and polysomnography in obese mice to assess breathing patterns during sleep and to determine the effect of obesity on apnea generation. We hypothesized that genetically obese ob/ob mice would exhibit less variability in breathing across the 24-h circadian cycle, be more prone to central apneas, and be more

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Hoshino, Tetsuro, Ryujiro Sasanabe, Kenta Murotani, et al. "Insomnia as a Symptom of Rapid Eye Movement-Related Obstructive Sleep Apnea." Journal of Clinical Medicine 9, no. 6 (2020): 1821. http://dx.doi.org/10.3390/jcm9061821.

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Rapid eye movement (REM)-related obstructive sleep apnea (OSA), a polysomnographic phenotype that affects 12–36% of OSA patients, is defined by apnea and hypopnea events that predominantly or exclusively occur during REM sleep. Recent studies indicated that REM-related OSA was associated with the development of nocturnal non-dipping of systolic and diastolic blood pressure, metabolic syndrome, diabetes, and depressive symptoms. However, to date, the association between REM-related OSA and insomnia still remains unclear. We investigated whether there was a difference between REM- and non-REM-re

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Ho, Minh Tam, Naomi Ghildiyal, Cesar Liendo, et al. "856 Sleep-writing, sleep-talking in uncontrolled REM-predominant obstructive sleep apnea." Sleep 44, Supplement_2 (2021): A333. http://dx.doi.org/10.1093/sleep/zsab072.853.

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Abstract Introduction Abnormal movements and behaviors during sleep are part of a larger group of nocturnal events that may occur during the sleep-wake cycle and/or the transitions into and out of sleep. We are presenting the case of OSA-related confusional arousals associated with sleep-writing and sleep-talking during REM-sleep. Report of case(s) 46 year old female with history of CAD, HTN, RLS, Anxiety, Depression, and REM predominant OSA (AHI of 2.9 per hour of sleep, REM AHI of 40 per hour of sleep, and oxygen saturation nadir of 91%), noncompliant with PAP therapy, returned to reestablis

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Hachul, Helena, Daniel N. Polesel, Luciana Tock, et al. "Sleep disorders in polycystic ovary syndrome: influence of obesity and hyperandrogenism." Revista da Associação Médica Brasileira 65, no. 3 (2019): 375–83. http://dx.doi.org/10.1590/1806-9282.65.3.375.

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SUMMARY OBJECTIVE: This study aims to evaluate the sleep of subjects with polycystic ovary syndrome (PCOS), with and without hyperandrogenism, in comparison with a healthy control group and examine the effects of hyperandrogenism and obesity on sleep parameters. METHODS: A total of 44 volunteers were recruited to participate in the study. Clinical, biochemical and polysomnographic parameters were used to diagnose PCOS and hyperandrogenism. The evaluation of sleep quality was made using validated questionnaires and polysomnography test. The frequency of obstructive sleep apnea was also compared

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Ren, R., Y. Zhang, L. Yang, L. Tan, T. Li, and X. Tang. "Apnea-hypopnea events during REM/non-REM sleep and hypertension among patients with obstructive sleep apnea." Sleep Medicine 64 (December 2019): S319. http://dx.doi.org/10.1016/j.sleep.2019.11.893.

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Baril, Andrée-Ann, Katia Gagnon, Pauline Brayet, et al. "Obstructive sleep apnea during REM sleep and daytime cerebral functioning: A regional cerebral blood flow study using high-resolution SPECT." Journal of Cerebral Blood Flow & Metabolism 40, no. 6 (2018): 1230–41. http://dx.doi.org/10.1177/0271678x18814106.

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Obstructive sleep apnea (OSA) predominantly during rapid eye movement (REM) sleep may have impacts on brain health, even in milder OSA cases. Here, we evaluated whether REM sleep OSA is associated with abnormal daytime cerebral functioning using high-resolution single-photon emission computed tomography (SPECT). We tested 96 subjects (25 F, age: 65.2 ± 6.4) with a wide range of OSA severity from no OSA to severe OSA (apnea–hypopnea index: 0–97 events/h). More respiratory events during REM sleep were associated with reduced daytime regional cerebral blood flow (rCBF) in the bilateral ventromedi

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Nakra, Neal, Tricia Morphew, Lois Sayrs, et al. "0792 Relationships Between Age, REM Sleep, and Sleep Disordered Breathing Across the First 24 Months of Life." SLEEP 47, Supplement_1 (2024): A339—A340. http://dx.doi.org/10.1093/sleep/zsae067.0792.

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Abstract Introduction Infant airway anatomy and immature central respiratory systems place infants at risk for sleep disordered breathing. Further, infant sleep is comprised of higher amounts of rapid eye movement (REM) sleep, with a steady decline across the first twenty-four months. Compared to the controlled breathing rate during non-REM (NREM), REM sleep has an erratic rate. The combination of immature anatomy and increased REM amount predispose infants to greater apnea risk, yet there is a poor characterization of age- and REM-associated changes in disordered breathing across the first tw

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Boopathy, Surya, Karim El-Kersh, Kahir Jawad, and Egambaram Senthilvel. "0525 Effect of Body Position and Sleep State on Obstructive Respiratory Events Distribution in Children with Down syndrome." SLEEP 46, Supplement_1 (2023): A231—A232. http://dx.doi.org/10.1093/sleep/zsad077.0525.

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Abstract Introduction The influence of body position and sleep state on obstructive respiratory events distribution in children with Down syndrome (DS) need further studies. Methods This was a single center, retrospective study that included children younger than 18 years old with DS who were evaluated for suspected sleep disordered breathing and underwent a full overnight polysomnography in an academic sleep disorders center over a period of 10 years. DS children with Obstructive apnea hypopnea index (OAHI) ≥ 1.5 were included in this study. Total OAHI, apnea hypopnea index (AHI) in different

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Peker, Yüksel. "REM Sleep: A Nightmare for Patients with Obstructive Sleep Apnea?" American Journal of Respiratory and Critical Care Medicine 190, no. 10 (2014): 1088–90. http://dx.doi.org/10.1164/rccm.201410-1897ed.

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Koo, Dae Lim, and Hyunwoo Nam. "Clinical Considerations of Obstructive Sleep Apnea with Little REM Sleep." Journal of Clinical Neurology 12, no. 4 (2016): 426. http://dx.doi.org/10.3988/jcn.2016.12.4.426.

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Iranzo, Alex, and Joan Santamaría. "Severe Obstructive Sleep Apnea/Hypopnea Mimicking REM Sleep Behavior Disorder." Sleep 28, no. 2 (2005): 203–6. http://dx.doi.org/10.1093/sleep/28.2.203.

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Ren, Rong, Ye Zhang, Linghui Yang, Lu Tan, Taomei Li, and Xiangdong Tang. "0582 Apnea-hypopnea Events During REM/non-REM Sleep And Hypertension Among Patients With Obstructive Sleep Apnea." Sleep 42, Supplement_1 (2019): A232. http://dx.doi.org/10.1093/sleep/zsz067.580.

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Khorramdel, Kazem, Selma Pasalari, and Mohammad Nami. "Evaluating the diagnosis and intervention of a sleepwalking disorder associated with violence: A case study." Medical Journal of Tabriz University of Medical Sciences 44, no. 1 (2022): 72–79. http://dx.doi.org/10.34172/mj.2022.016.

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This study aimed to investigate a case of sleep problems associated with violence (non-REM parasomnias) and obstructive sleep apnea (OSA) besides related therapeutic approaches. The studied case in the present study was a 60-year-old man with a family history of this sleep disorder. The treatment plan in the present study was as follows: Execution of the principles of sleep hygiene by the patient, use of the continuous positive airway pressure machine (CPAP), and eight sessions of weekly biofeedback therapy. Before the intervention, the subject suffered from anxiety, minor depression, moderate

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Findley, Larry J., Stephen C. Wilhoit, and Paul M. Suratt. "Apnea Duration and Hypoxemia During REM Sleep in Patients with Obstructive Sleep Apnea." Chest 87, no. 4 (1985): 432–36. http://dx.doi.org/10.1378/chest.87.4.432.

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Schneider, H., C. D. Schaub, C. A. Chen, et al. "Effects of arousal and sleep state on systemic and pulmonary hemodynamics in obstructive apnea." Journal of Applied Physiology 88, no. 3 (2000): 1084–92. http://dx.doi.org/10.1152/jappl.2000.88.3.1084.

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During obstructive sleep apnea (OSA), systemic (Psa) and pulmonary (Ppa) arterial pressures acutely increase after apnea termination, whereas left and right ventricular stroke volumes (SV) reach a nadir. In a canine model ( n = 6), we examined the effects of arousal, parasympathetic blockade (atropine 1 mg/kg iv), and sleep state on cardiovascular responses to OSA. In the absence of arousal, SV remained constant after apnea termination, compared with a 4.4 ± 1.7% decrease after apnea with arousal ( P < 0.025). The rise in transmural Ppa was independent of arousal (4.5 ± 1.0 vs. 4.1 ± 1.2 mm

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Qasmi, Syed Talha, and Andre Aguillon. "1025 Schizophrenic Patient with Large REM Rebound Following Treatment of Severe Obstructive Sleep Apnea." SLEEP 46, Supplement_1 (2023): A450. http://dx.doi.org/10.1093/sleep/zsad077.1025.

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Abstract Introduction We present a case of uncontrolled schizophrenia with severe obstructive sleep apnea (OSA) and significant REM rebound after bilevel positive airway pressure (BPAP) therapy. Report of case(s) A 74-year-old female, with Schizophrenia on anti-psychotic therapy, presented to the sleep clinic due to excessive daytime sleepiness (EDS) and an Epworth score of 21/24. Diagnostic polysomnogram (PSG) reported an AHI of 162.1 events/hour with SaO2 nadir of 71% with sleep efficiency of 31.6% and no REM-sleep, consistent with severe OSA. The next morning, multiple sleep latency testing

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Baran, A. S., A. C. Richert, K. Ansarin, H. P. Roffwarg, and A. Halaris. "REM sleep suppression in patients with obstructive sleep apnea: Effects of REM suppressing medication." European Neuropsychopharmacology 11 (January 2001): S347. http://dx.doi.org/10.1016/s0924-977x(01)80516-2.

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Kumagai, Hajime, Hiroyuki Sawatari, Tetsuro Hoshino, et al. "Effects of Continuous Positive Airway Pressure Therapy on Nocturnal Blood Pressure Fluctuation Patterns in Patients with Obstructive Sleep Apnea." International Journal of Environmental Research and Public Health 19, no. 16 (2022): 9906. http://dx.doi.org/10.3390/ijerph19169906.

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This retrospective study was designed to evaluate the effects of continuous positive airway pressure (CPAP) therapy, a well-established treatment for obstructive sleep apnea (OSA), on nocturnal blood pressure fluctuations (NBPFs) during rapid eye movement (REM) and non-REM sleep, and to evaluate the NBPF patterns in patients with OSA. We included 34 patients with moderate-to-severe OSA who underwent polysomnography using pulse transit time before and at 3–6 months after CPAP therapy. Nocturnal BP and NBPF frequency in REM and non-REM sleep were investigated, as well as NBPF pattern changes aft

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