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Rozprawy doktorskie na temat „Renal tissue”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Chapman, I. D. "Studies on renal tissue kallikrein : Relevance in essential hypertension." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375012.

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Schneider, Caitlin Marie. "Ultrasound elastography for intra-operative use and renal tissue imaging." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61246.

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The kidney is a vital organ within the human body and improvements in the ability to characterize the kidney tissue can create benefits for patients with kidney tumors and for kidney transplant recipients. Often, changes in tissue health or development of cancer are manifested in changes in tissue structure that affect tissue elastic properties. For example, the cancerous tissue of renal cell carcinoma is stiffer than healthy kidney tissue, and the development of fibrosis, which impairs kidney function, also causes the tissue to become stiffer over time. These changes can be imaged with ultr

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3

Sevastos, Jacob Prince of Wales Clinical School UNSW. "The role of tissue factor in renal ischaemia reperfusion injury." Awarded by:University of New South Wales. Prince of Wales Clinical School, 2006. http://handle.unsw.edu.au/1959.4/27416.

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Reperfusion injury may mediate renal dysfunction following ischaemia. A murine model was developed to investigate the role of the tissue factor-thrombin-protease activated receptor pathway in renal ischaemia reperfusion injury (IRI). In this model, mice received 25 minutes of ischaemia and subsequent periods of reperfusion. C57BL6, protease activated receptor-1 (PAR-1) knockout mice, and tissue factor (TF) deficient mice were used. Following 24 hours IRI, PAR-1 deficiency resulted in protection against severe renal failure compared to the C57BL6 mice (creatinine, 118.2 ?? 6.3 vs 203 ?? 12 ??mo

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Yokoi, Hideki. "Role of connective tissue growth factor in renal tubulointerstitial fibrosis." Kyoto University, 2005. http://hdl.handle.net/2433/144757.

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5

Moser, Rudolf. "Changes in renal tissue and circulating catecholamines during gentamicin-induced acute renal failure in the rat /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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6

Hiley, Christopher. "Immunocytochemical studies of antioxidant enzyme expression in developing human tissue." Thesis, Keele University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260287.

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7

Alouffi, Sultan Mohammed R. "Investigation into the effects of end stage renal failure and renal replacement therapy on adipose tissue metabolism." Thesis, University of Liverpool, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569174.

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Background and aims: End stage renal disease (ESRD), an increasing global major public health problem, has greatly increased cardiovascular disease risk (CVD) than the general population for unknown reasons. Preliminary data suggest that adipose tissue, shown to contribute to CVD risk in non-ESRD populations, may also play a part in ESRD. Adipose tissue is a complex organ which not only functions as a fat storing depot, but also plays an essential role in lipid metabolism. Recently, researchers have recognized that adipose tissue is also an endocrine organ since it secretes several cytokines a

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8

Грицюк, Мар'яна Іванівна. "Changes in renal interstitial tissue in experimental animals with diabetes mellitus." Thesis, Метаболічний синдром у загальноклінічній практиці // Матеріали науково-практичної інтернет-конференції з міжнародною участю. – Чернівці: Медуніверситет, 2016. – 58 с, 2016. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/11918.

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9

Brant, Stephen. "Distribution of renal S100 proteins in physiological and pathological models." Thesis, University of East London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342101.

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10

Fainberg, Hernan Pablo. "Alterations induced by juvenile obesity on the renal tissue of nutrient restricted offspring." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11207/.

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Human epidemiological studies have indentified obesity as an independent risk factor for renal disease. In addition, maternal nutrient restriction (MNR) during gestation results in a series of adaptations that may predispose those offspring to obesity and hypertension. Recent reports demonstrated that obese sheep exposed to MNR during early to mid gestation have a predisposition to ectopic lipid deposition in the heart and a rise in necrotic adipocytes, which are markers of severe metabolic dysfunction. Surprisingly, in this model of MNR, the renal tissue of those offspring showed an apparent

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11

Whitehouse, Tony. "Validation of a model measuring rat intra-renal blood flow and tissue oxygen." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445948/.

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Acute renal failure (ARF) is a common condition on the intensive care unit (ICU) and may affect up to 40% of patients (de Mendonca, A. et al., 2000), (Korkeila, M. et al., 2000). Pathophysiological mechanisms remain unclear. Patients who die from sepsis have kidneys that look histologically normal (Hotchkiss, R.S. et al., 1999), while the renal prognosis in survivors is good with < 2% requiring long-term renal replacement therapy (Noble, J.S. et al., 2001). This has led some authors to suggest that acute renal failure is a physiological process designed to shut down vital processes and protect

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12

Zanusso, Ilenia. "Acellular matrices as tool for renal progenitor differentiation studies and tissue engineering of blood vessels." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423024.

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AMs seem to be a very promising scaffold in TE and can be considered as temporary inductive site-appropriate templates to support the growth, differentiation, and function of the parenchymal cell population of each organ. Nowadays, TE techniques are used both to develop tissue substitutes ex vivo and as reliable tool to investigate cell behaviour, differentiation and proliferation in 3-dimentional environments. In this work the following two different projects have investigated both potentialities using tissue-specific AMs: 1- influence of AMs on differentiation of kidney progenitor cells f

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13

Mountfort, Simon A. "The development of secondary io mass spectrometry for the analysis of aluminium and other trace elements in biological tissue." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357231.

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14

Rabsteyn, Armin [Verfasser], and Stefan [Akademischer Betreuer] Stevanovic. "Mass spectrometry-based analysis of the HLA-ligandomes of renal cell carcinoma and benign renal tissue / Armin Rabsteyn ; Betreuer: Stefan Stevanovic." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1198972769/34.

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15

Balogun, Elizabeth Olayinka. "A functional role for heme oxygenase-1 during hypothermic storage and reperfusion in renal tissue." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409630.

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16

Winn, Simon. "An investigation of the actions of connective tissue growth factor on human renal epithelial cells." Thesis, St George's, University of London, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.754078.

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Introduction. Connective tissue growth factor (CTGF) is the only CCN member recognized as a mediator of chronic fibrotic disease. Accumulating evidence suggests that CTGF is important as a downstream effector of transforming growth factor (TGFβ) in modulating a sustained pro-fibrotic signal in in vivo models. Moreover, in cultured human proximal tubule epithelial cells (PTECs) CTGF mRNA is readily upregulated by TGFP and the nascent protein accumulates extracellularly. How pro-fibrotic signalling occurs is yet to be ascertained but it likely involves extracellular interactions with secreted CT

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17

Chromek, Milan. "Urinary tract infection and renal scarring /." Stockholm, 2006. http://diss.kib.ki.se/2006/7140-844-4/.

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18

Mia, Sobuj [Verfasser], and Florian [Akademischer Betreuer] Lang. "AMP-Activated Protein Kinase alpha1 Dependent Signaling in Renal Tissue Fibrosis / Sobuj Mia ; Betreuer: Florian Lang." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1164017969/34.

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19

Zerati, Marcelo. "Estudo de fatores prognósticos moleculares no carcinoma renal de células claras pela técnica de tissue microarray." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-23082011-143257/.

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INTODUÇÃO: O carcinoma renal (CR) é uma doença agressiva, e sua incidência vem aumentando. A variante de células claras (CRCC) é a mais comum e apresenta comportamento biológico mais agressivo. Os recentes avanços no conhecimento da biologia molecular do tumor demonstram que a oncogênese dos diversos tipos histológicos é regida por mecanismos celulares diversos. Os modelos prognósticos atuais vêm procurando incorporar os recentes avanços da biologia molecular, com o intuito de melhorar sua capacidade de predizer a evolução e o desfecho destes pacientes. OBJETIVOS: Correlacionar a imunoexpressã

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20

Nagarajan, Vivek Krishna. "REAL-TIME ASSESSMENT OF THERMAL TISSUE DAMAGE USING DIFFUSE REFLECTANCE SPECTROSCOPY." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1494313847936136.

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21

Lidgren, Anders. "Hypoxia inducible factor-1α in renal cell carcinoma". Doctoral thesis, Umeå universitet, Kirurgisk och perioperativ vetenskap, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1462.

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Hypoxia Inducible Factor-1α in Renal Cell Carcinoma Departments of Surgical and Perioperative Sciences, Urology and Andrology; Radiation Sciences, Oncology; Medical Biosciences, Pathology; and Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all human cancers. A distinguished feature of RCC is vascularisation and among the three dominating RCC types conventional RCC (cRCC) generally is more vascularised than papillary RCC (pRCC) and chromophobe RCC (chRCC). Angiogenesis is a critical step in tumour

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22

Esaki, Roy Kuniaki 1982. "A new surgical model or studying the healing response of renal tissue in the presence of collagen-glycosaminoglycan matrices." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32819.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.<br>Includes bibliographical references (p. 45-46).<br>The treatment of renal trauma can involve the surgical removal of part of a patient's kidney, which leads to scarring, distortion of the renal architecture, and potentially renal insufficiency. Current research suggests that the implantation of collagen-glycosaminoglycan (GAG) extra-cellular matrices after traumatic renal injury prevents contraction, decreases scarring, and may ultimately induce the regeneration of functional renal tissues after inj

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23

Poornejad, Nafiseh. "Decellularization and Recellularization Processes for Whole Porcine Kidneys." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6554.

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Concern over kidney disease has increased dramatically in recent years within the medical community. It is estimated that approximately one in fifteen Americans, nearly 20 million people, experience chronic kidney disease with most of those diagnosed progressing to kidney failure. The ultimate treatment available for end stage renal failure is whole kidney transplantation. However, there are very few kidneys available for patients to receive and those patients who are fortunate enough to receive an organ must remain on immunosuppressive medication for the remainder of their lives. The United S

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24

Santos, Juliana Passos Alves dos. "Terapia celular em gatos portadores de doença renal crônica: avaliação laboratorial e imagiológica." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-05072013-091420/.

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A doença renal crônica é uma das maiores causas de enfermidade e óbito de gatos geriátricos e carreia o declínio da função renal. A forma crônica é caracterizada por persistir um período prolongado de tempo e de prognóstico reservado. Atualmente, a reposição hídrica, a hemodiálise e o transplante são as opções de terapia. Como a terapia com células-tronco tem sido extensivamente estudada nos últimos anos devido a sua capacidade de melhorar a função de órgão lesionados, inclusive os rins, este estudo teve como objetivo avaliar o efeito do transplante de células-tronco de tecido adiposo de gatos

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25

Healing, Guy. "The role of iron and oxygen-derived free radicals in the pathogenesis of renal tissue injury during ischaemia and reperfusion." Thesis, Open University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328524.

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26

Frohlich, Else Marie. "A microscale tissue modeling device (MTMD) to influence renal epithelial cell function through controlled topography and flow-induced shear stress." Thesis, Boston University, 2011. https://hdl.handle.net/2144/38033.

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Thesis (M.S.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Physiologically representative and well-controlled in vitro models of human tissue are required to safely, accurately, and rapidly develop therapies for disease. Current in vitro models do not possess appropri

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27

Vilella-Arias, Santiago Andrés. "Estudo de candidatos a biomarcadores moleculares de prognóstico em carcinoma renal de células claras." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-20032014-075848/.

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O carcinoma de células renais (CCR) é o tumor mais agressivo que afeta o rim de pessoas adultas. O CCR é uma doença heterogênea, com diferentes alterações moleculares e variados patrões histológicos e clínicos que apresentam evolução diferente. Atualmente apenas variáveis anatomopatológicas clássicas são utilizadas para determinar o prognóstico dos pacientes. Utilizando uma plataforma de microarranjos de DNA, nosso grupo identificou em um trabalho anterior um conjunto de genes que se encontram diferencialmente expressos em tumores de rim. Neste estudo, nove candidatos foram selecionados para a

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28

Solomon, Daniel Aran. "Decision Making by Patients Awaiting Kidney Transplant." Yale University, 2010. http://ymtdl.med.yale.edu/theses/available/etd-03052010-141133/.

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Involving patients in medical decisions by acknowledging patients personal values and individual preferences has become an important goal of providing ethical medical care. Despite a general movement towards a model of shared decision-making, many patients do not fully meet their preferred role in practice. The decision whether or not to accept a kidney once it is offered to a patient awaiting transplant has historically been made predominantly by the transplant surgeon with little involvement from the patient. Because dialysis can provide long-term renal replacement, declining a kidney is a v

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Chaudry, Qaiser Mahmood. "Improving cancer subtype diagnosis and grading using clinical decision support system based on computer-aided tissue image analysis." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47745.

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This research focuses towards the development of a clinical decision support system (CDSS) based on cellular and tissue image analysis and classification system that improves consistency and facilitates the clinical decision making process. In a typical cancer examination, pathologists make diagnosis by manually reading morphological features in patient biopsy images, in which cancer biomarkers are highlighted by using different staining techniques. This process is subjected to pathologist's training and experience, especially when the same cancer has several subtypes (i.e. benign tumor subtyp

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Sharkey, Don. "The impact of pre- and postnatal nutrition on cellular stress and inflammation in the renal and perirenal adipose tissue of sheep." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523579.

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McElligott, Anthony Morgan. "The role of matrix metalloproteinases and their inhibitors, the tissue inhibitors of metalloproteinases, in renal cell carcinoma cell invasion and metastasis." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326125.

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Athanassopoulou, F. "A study of myxosporea SPP in Rutilus L. (roach) with particular reference to Myxidium rhodei Leger, 1905 in the renal tissue." Thesis, University of Stirling, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277409.

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Jacobsen, Jan. "Vascular endothelial growth factor in renal cell carcinoma." Doctoral thesis, Umeå : Kirurgisk och perioperativ vetenskap, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-713.

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Boissier, Romain. "La fraction vasculaire stromale issue du tissu adipeux en urologie : propriétés thérapeutiques et modèle d'évaluation de la vasculocompétence du transplant rénal." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0691.

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La Fraction Vasculaire Stromale (FVS) est une population cellulaire obtenue par digestion enzymatique du tissu adipeux.L’objectif de ce travail était de transposer le modèle de la FVS en urologie, en évaluant ses propriétés thérapeutiques dans un modèle animal de lésion sphinctérienne urétrale puis en tant que matériel non invasif d’étude des altérations associé à la moindre fonction de transplants rénaux prélevés chez le donneur marginal, ou ECD (Extended Criteria Donor).1. L’injection de FVS autologue dans un modèle porcin de lésion urétérale entrainait une réduction significative de la surf

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35

Sandlund, Johanna. "Angiogenesis in human renal cell carcinoma : hypoxia, vascularity and prognosis." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1331.

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Cuartero, Sala Mireia. "Tissue inhibitor of metalloproteinases-2 (TIMP-2) e Insulin-like growth factor-binding protein 7 (IGFBP7): Biomarcadores precoces de disfunción renal aguda en el paciente crítico séptico." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/386498.

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La disfunción renal aguda (DRA) es una enfermedad frecuente en las unidades de cuidados intensivos (UCI), y con frecuencia se asocia a la sepsis. La DRA y la sepsis son factores de riesgo recíprocos. El diagnóstico de DRA ha cambiado en la última década con la aparición de la clasificaciones RIFLE, AKIN y KDIGO. Todas ellas se basan en la creatinina plasmática y la diuresis. Aunque la creatinina sigue siendo el gold-standard para el diagnóstico de DRA, es un biomarcador funcional tardío y no específico. Este hecho ha promovido el estudio de nuevos biomarcadores. Estudios recientes han mostrado

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Caldas, Heloisa Cristina. "Efeito das células derivadas da medula óssea no tratamento da insuficiência renal crônica experimental." Faculdade de Medicina de São José do Rio Preto, 2011. http://bdtd.famerp.br/handle/tede/104.

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Made available in DSpace on 2016-01-26T12:51:30Z (GMT). No. of bitstreams: 1 heloisacaldas_tese.pdf: 13961449 bytes, checksum: adc041656d053c466bd2f0851119388c (MD5) Previous issue date: 2011-07-26<br>Chronic renal failure (CRF) is characterized by progressive and irreversible loss of renal function and its treatment generates significant public spending for maintenance and care of patients on dialysis. Stem cell (SC) therapy, in its potential for treatment of chronic diseases, may be a promising strategy for repairing the damage from or slowing the progression of CRF. There are questions ab

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38

Giuliani, Stefano. "AMNIOTIC FLUID STEM CELLS AND KIDNEY REGENERATION." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426889.

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Acute Kidney Disease (CKD) is a major public health problem that affects some 3-7% of patients admitted to the hospital and approximately 25-30% of patients in the intensive care unit. None of the existing therapies are exempt from side effects and kidney physiological functionality is never restored. Transplantation has been reported as the preferred cure for CKD management but organ shortage and risks due to the immunosuppressive therapy makes it far from being the perfect treatment for ESRD. In this study we have focused our attention on finding novel strategies, in vitro and in vivo, to ob

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Li, Dailin. "Regulation of Na⁺, K⁺-ATPase activity by protein phosphatase-1 and protein kinase C : studies in infant and adult renal tissue and on vascular smooth muscle cells /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3563-7/.

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Dias, Cinthia. "Efeito das células-tronco pluripotentes induzidas (iPS) no tratamento da insuficiência renal crônica experimental." Faculdade de Medicina de São José do Rio Preto, 2015. http://hdl.handle.net/tede/270.

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Submitted by Fabíola Silva (fabiola.silva@famerp.br) on 2016-06-21T17:12:33Z No. of bitstreams: 1 cinthiadias_dissert.pdf: 1995817 bytes, checksum: 27317444195c0604e0ed14f9ac182ee5 (MD5)<br>Made available in DSpace on 2016-06-21T17:12:33Z (GMT). No. of bitstreams: 1 cinthiadias_dissert.pdf: 1995817 bytes, checksum: 27317444195c0604e0ed14f9ac182ee5 (MD5) Previous issue date: 2015-08-25<br>Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP<br>Introduction: Stem cell therapy is a promising strategy to repair or delay the progression of chronic renal failure (CRF). Induced plurip

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Harada, Paulo Henrique Nascimento. "Avaliação da associação da gordura pericárdica medida pela tomografia computadorizada com o escore de cálcio coronário em pacientes renais crônicos não dialíticos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-23112015-164730/.

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A gordura pericárdica (GP), um componente do tecido adiposo visceral, tem sido consistentemente relacionada com aterosclerose coronária na população geral. Este estudo avaliou a associação entre GP e a calcificação arterial coronária (CAC) em pacientes com doença renal crônica (DRC) não dialítica. Este é um estudo transversal post-hoc da linha de base de coorte prospectiva de 117 pacientes com DRC em seguimento ambulatorial sem doença coronária manifesta (idade, 56,8 ± 11 anos; 64% do sexo masculino; 95,1% hipertensos; 25,2% diabéticos; 15,5% com história prévia de tabagismo; e estágios 2 a 5

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Araújo, Bibiana Verlindo de. "Modelagem farmacocinética-farmacodinâmica do antifúngico voriconazol." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/12602.

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Objetivos: O objetivo deste trabalho foi o desenvolvimento de um modelo farmacocinético/farmacodinâmico (PK/PD) para descrever o efeito antifúngico voriconazol (VRC) contra espécies de Candida. Método: Para alcançar este objetivo as seguintes etapas foram realizadas: i) foi adaptado e padronizado modelo de candidíase disseminada em ratos Wistar imunocompetentes e imunocomprometidos com Candida sp.; ii) foram validados métodos analíticos de LC-MS/MS e LC-UV para o doseamento do VRC em amostras de plasma e microdialisado de tecido; iii) foram estabelecidas as condições para microdiálise do VRC e

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Pepineli, Rafael. "Avaliação do potencial papel imunomodulador de células-tronco mesenquimais derivadas de tecido adiposo, no modelo experimental de transplante renal em ratos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-06042018-120932/.

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Estudos com células tronco mesenquimais (CTm) têm despertado grande interesse devido a seu promissor potencial terapêutico e representam uma alternativa para o tratamento de diversas patologias em diferentes órgãos, inclusive em transplante renal. A rejeição crônica é um dos maiores desafios no transplante tardio e se caracteriza por perda progressiva da função renal causado pela intensa fibrogênese no aloenxerto. Os tratamentos convencionais com imunossupressores, apesar de reduzirem significativamente as crises de rejeição aguda, não interferem na sobrevida do enxerto a longo prazo. A compre

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Carmo, Lílian Pires de Freitas do. "Avaliação da performance dos biomarcadores e da bioquímica urinária no diagnóstico de injúria renal aguda em pacientes críticos: coorte prospectiva." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-06122016-104121/.

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Introdução: Injúria Renal Aguda (IRA) é uma patologia grave e com elevada incidência em pacientes críticos. Apesar do avanço no conhecimento fisiopatológico ocorrido nas últimas décadas, pouco desse conhecimento foi traduzido em terapia para IRA já instalada. Medidas preventivas para evitar a progressão da IRA em momentos iniciais da injúria continuam a ser o principal foco na terapia da IRA. Nesse contexto, o diagnóstico e determinação precoce da gravidade da injúria renal são fundamentais para evitar a progressão para estágios mais graves e diminuir a morbidade e a mortalidade associadas à s

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Ferreira, Gustavo Fernandes. "Avaliação do metabolismo mineral do doador de rim em vida." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-09122014-140225/.

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Introdução: Doador de rim em vida é uma importante fonte de órgão para os pacientes portadores de doença renal crônica (DRC). Os doadores experimentam uma redução abrupta da taxa de filtração glomerular (TFG) e adaptações ao metabolismo mineral demandam estudos nesta população. Nós avaliamos prospectivamente esta adaptação em doadores de rim em vida. Métodos: Entre janeiro de 2010 a agosto de 2011, no hospital das Clínicas de São Paulo e na Universidade de Miami, realizamos a avaliação prospectiva do metabolismo mineral e da função renal por 1 ano em 74 doadores de rim em vida. Medimos a taxa

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Sharp, Thomas. "Real-time million-synapse simulation of cortical tissue." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/realtime-millionsynapse-simulation-of-cortical-tissue(687a0eb1-3284-43c4-9dcd-3760444701cb).html.

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The nervous system may be simulated as a network of model neurons as a means to understand the function of the brain. Complex as the mammalian nervous system is, such simulations of any significant scale are computationally and energetically expensive. SpiNNaker is a computer architecture designed to advance the feasible scale of neural tissue models using fifty thousand chips, each containing eighteen low-power processors, to model one billion neurons and one trillion synapses in real-time. This dissertation demonstrates the success of prototype hardware with detailed models of the rodent som

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Rodriguez-Sanchez, Nidia. "Hydration and fluid balance : studies on body composition, drink formulation and ageing." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/25390.

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The thesis reports on 6 studies (2 of which were part of a multi-centre trial) examining hydration and fluid balance. The first study described in this thesis investigated the impact of hydration status on Dual energy x-ray absorptiometry (DXA) and other methods that are popular tools to determine body composition in athletes. We observed that it is important to ensure a euhydration when assessing body composition, particularly when considering changes associated with nutritional or exercise interventions. The second and third studies reported identified beverages that promote longer term flui

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Lee, Z. S. "Towards real-time imaging of strain in soft tissue." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20003/.

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Prapansilp, Panote. "Molecular pathological investigation of the pathophysiology of fatal malaria." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e966a2f2-a37d-4586-b09e-2bb616e5dce2.

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Malaria remains one of the world's major health problems, especially in developing countries. A better understanding of the pathology and pathophysiology of severe malaria is key to develop new treatments. Different approaches have been used in malaria research including the in vitro co-culture models with endothelial cells and both murine and simian animal models. However these are open to controversy due to disagreement on their representativeness of human disease. Using human post-mortem tissue in malaria research is another important approach but is practically challenging, limiting the av

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Comas, Olivier. "Real-time Soft Tissue Modelling on GPU for Medical Simulation." Phd thesis, Université des Sciences et Technologie de Lille - Lille I, 2010. http://tel.archives-ouvertes.fr/tel-00561299.

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Modéliser la déformation de structures anatomiques en temps réel est un problème crucial en simulation médicale. En raison des grandes différences existantes dans leur forme et leur constitution, un modèle unique est insuffisant face à la variété des comportements mécaniques. Par conséquent, nous avons identifié deux principaux types de structures: les organes pleins (cerveau, foie, prostate etc.) et les organes creux (colon, vaisseaux sanguins, estomac etc.). Notre réponse à cette problématique est double. Notre première contribution est une implémentation GPU d'un modèle éléments finis qui e

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