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Rozprawy doktorskie na temat „Respiratory infection”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Oliveira, Ana Luísa Araújo. "Adventitious respiratory sounds in children with respiratory infection." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13734.

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Mestrado em Fisioterapia<br>Background: Lower respiratory tract infections (LRTI) are the leading cause of hospital visits in children under 5 years old. Therefore, there is an urgent and unmet need to develop objective, reliable and quick measures for respiratory paediatric assessment. Computerised adventitious respiratory sounds (ARS) have shown to be objective and reliable to assess/monitor respiratory diseases; however its application in children with LRTI is unknown. Aim: To characterise/compare ARS in healthy children and children with LRTI. Methods: A cross-sectional descriptive

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Del, Valle Mendoza Juana, Tapia Ángela Cornejo, Pablo Weilg, et al. "Incidence of Respiratory Viruses in Peruvian Children With Acute Respiratory Infections." John Wiley & Sons, 2015. http://hdl.handle.net/10757/347016.

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jdelvall@upc.edu.pe<br>Acute respiratory infections are responsible for high morbi–mortality in Peruvian children. However, the etiological agents are poorly identified. This study, conducted during the pandemic outbreak of H1N1 influenza in 2009, aims to determine the main etiological agents responsible for acute respiratory infections in children from Lima, Peru. Nasopharyngeal swabs collected from 717 children with acute respiratory infections between January 2009 and December 2010 were analyzed by multiplex RT-PCR for 13 respiratory viruses: influenza A, B, and C virus; parainfluenza virus

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Pruikkonen, H. (Hannele). "Viral infection induced respiratory distress in childhood." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207919.

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Abstract Dyspnoea associated with respiratory infection is a common symptom in infancy and early childhood. Inspiratory stridor is the main symptom in cases of croup and expiratory wheezing in cases of bronchiolitis, obstructive bronchitis and acute asthma exacerbations. Dyspnoea associated with respiratory infection is a common cause of emergency department visits and unplanned hospital admissions among infants and preschool children. The assessment of dyspnea associated with acute childhood respiratory infection is largely subjective, and evidence regarding the severity of acute dyspnoea is

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4

Hussain, Imran Raza. "The immunobiology of respiratory syncytial virus infection." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289569.

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Wrightson, John M. "Pathogen identification in lower respiratory tract infection." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:30c757ec-99b7-492e-a12e-ff996581863a.

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Treatment of lower respiratory tract infection (pneumonia and pleural infection) relies on the use of empirical broad spectrum antibiotics, primarily because reliable pathogen identification occurs infrequently. Another consequence of poor rates of pathogen identification is that our understanding of the microbiology of these infections is incomplete. This thesis addresses some of these issues by combining the acquisition of high quality lower respiratory tract samples, free from nasooropharyngeal contamination, with novel molecular microbiological techniques in an attempt to increase rates of

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Clark, Tristan William. "The role of respiratory virus infection in adults hospitalised with acute respiratory illness." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28098.

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Acute respiratory illness represents a large proportion of adult patients admitted to secondary care. Many of these patients have respiratory virus infection but the exact burden of disease in defined clinical groups is unknown. Rhino-enteroviruses are increasingly implicated in severe acute respiratory illness in adults and advances in molecular diagnostics have led the recognition of high strain diversity and to the discovery of a new species (HRV-C). Biomarkers such as procalcitonin and C reactive protein may be able to identify patients with acute respiratory illness without bacterial infe

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7

Tong, Jie [Verfasser]. "Co-infection of respiratory epithelial cells by respiratory viruses and streptococci / Jie Tong." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2018. http://d-nb.info/1162715758/34.

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Shi, Ting. "Epidemiology of respiratory syncytial virus associated acute lower respiratory infection in young children." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23610.

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Introduction Acute lower respiratory infection (ALRI) remains as a leading cause of childhood morbidity and mortality. With the continued universal vaccination campaign against bacterial pathogens, an increase in relative proportion of respiratory viruses contributing to ALRI is anticipated. Respiratory syncytial virus (RSV) has been recognised as the most common pathogen identified in young children presenting with ALRI as well as an important cause of hospital admission. This thesis aims to estimate the aetiological roles and attributable fractions of common respiratory viruses among ALRI ca

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9

Barasheed, Osamah Abdullah A. "Prevention of respiratory viral infection among Hajj pilgrims." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23506.

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Hajj is one of the five basic tenets of Islam. Every practicing, financially and physically capable, Muslim is required to perform Hajj at least once in his/her lifetime. Each year up to three million people from more than 180 countries assemble in Mecca, Saudi Arabia, to perform Hajj pilgrimage. Severe crowding, shared accommodation, poor personal hygiene, and environmental pollution at Hajj may collectively lead to increased transmission of respiratory viruses. Influenza-like illness (ILI) is one of the most common medical presentations to primary care, mostly due to viral infection, in whic

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10

Kristo, A. (Aila). "Acute rhinosinusitis during upper respiratory infection in children." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278720.

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Abstract Acute rhinosinusitis is estimated to be one of the most common diseases in childhood. Still, the diagnostics and clinical relevance of this disease are controversial. Bacterial rhinosinusitis cannot be differentiated from mere rhinitis on clinical grounds alone. Abnormal radiologic findings have been found to be common in child and adult volunteers without sinus symptoms and in adults during viral upper respiratory infection. In children, the results of the few placebo-controlled studies on the benefit of antimicrobial treatment of clinically diagnosed acute rhinosinusitis are contro

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11

Manley, Grace C. A. "The roles of DUSPs in respiratory viral infection." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19257/.

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12

Mize, Maximillion. "Interleukin-17A Worsens Severe Murine Respiratory Mycoplasma Infection." Thesis, University of North Texas Health Science Center at Fort Worth, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10843638.

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<p> The purpose of these studies was to determine the role of Interleukin-17A (IL-17A) in the immune response to respiratory mycoplasma infection. Serum levels of IL-17A increase in disease-susceptible BALB/c mice, but not disease-resistant C57BL/6 mice, infected with <i>Mycoplasma pulmonis</i>. Increased serum IL-17A was associated with mycoplasma pathology during infection in BALB/c mice, including: the presence of pulmonary neutrophils, progressive weight loss, and the development of inflammatory lung lesions. </p><p> Neutralizing the function of IL-17A using monoclonal anti-IL-17A antib

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13

Cline, Troy. "Innate Immune Mechanisms of Controlling Respiratory Virus Infection." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1262099397.

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14

Deacon, Jill. "Antimicrobial nanotherapies for respiratory infection in cystic fibrosis." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695326.

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This thesis presents the design, development and efficacy of antimicrobial nanotherapies, to overcome the challenges faced by conventional antimicrobial delivery for the treatment of Pseudomonas aeruginosa respiratory infections in cystic fibrosis (CF). In the CF lungs, mucus and biofilms pre.sent complex barriers to the optimal delivery of antimicrobial therapy, leading to low antimicrobial exposure to resident bacteria and inadequate eradication. Respiratory disease, associated with chronic respiratory infection, is ultimately the main cause of morbidity and mortality in CF patients. There i

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15

Brown, Helen. "Host responses to respiratory infection in cystic fibrosis." Thesis, University of Bath, 2001. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392017.

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Xie, Xiaojian. "Evaporation and movement of respiratory droplets in indoor environments." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40987802.

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Agoti, Charles Nyaigoti. "Genetic diversity of respiratory syncytial virus (RSV) in relation to infection and re-infection." Thesis, Open University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664468.

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Background. Respiratory syncytial virus (RSV) causes recurrent epidemics in communities and repeated reinfections of individuals throughout life. The extent to which this is a consequence of antigenic diversity of the virus caused by genetic evolution is poorly defined. Clarification of these phenomena has implications for our understanding of RSV persistence and vaccine control. Further, studying RSV epidemics genetic composition contributes to understanding of the transmission dynamics of this virus. Methods. RSV positive specimens were available from the freezer archives of three epiderrnol

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18

Graham, Neil M. H. "Psychosocial factors in the epidemiology of acute respiratory infection /." Title page, contents, thesis synopsis and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09MD/09mdg741.pdf.

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19

Snelgrove, Robert. "Manipulation of the myeloid immune compartment during respiratory infection." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/11917.

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20

Droniou, Magali Eliane. "Localisation of human respiratory syncytial virus proteins during infection." Thesis, University of Warwick, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487956.

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Human respiratory syncytial vilUs (hRSV) is an important pathogen causing respiratory disease, affecting predominantly the infant and elderly populations. No effective vaccine or anti-viral treatment is yet available against this virus. hRSV is a negative-sense, nonsegmented RNA virus, which encodes II proteins. The N, P, Land M2-1 proteins constitute the viral polymerase and the M2-2 protein acts as a regulatory element in the balance between transcription and replication. The G protein allows attachment of the virus to cellular glycosaminoglycans receptors, and the F protein mediates entry o

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21

Almond, Elizabeth Jennifer Philippa. "Epstein-Barr virus infection of the lower respiratory tract." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31208484.

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22

Weber, Martin Willi. "Infection with the respiratory syncytial virus in the Gambia." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262711.

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23

Van, der Heyde Yolande. "Lower respiratory tract infection in sudden unexpected infant deaths." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/14391.

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Pneumonia due to polymicrobial infection is known to increase the severity and risk of fatality among young children. A retrospective study was undertaken on Sudden Unexpected Infant Death cases occurring, between 1 May and 30 September 2009, which were admitted to a medico-legal mortuary servicing the Cape Town western metropole. Published studies have shown the risk factors for lower respiratory tract infection to include lack of breast feeding, prenatal and environmental tobacco smoke exposure, prematurity, immunosuppression, underlying medical conditions and overcrowding. The present study

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24

Hardisty, Gareth Rhys. "The effect of on-going and persistent infection on acute respiratory infection with influenza A." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22080.

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Humans are subject to infection with a wide range of commensal and pathogenic organisms. Each pathogen requires an appropriate immune response to eliminate or control the invading organism and minimise pathology. Many pathogens have evolved strategies to subvert or manipulate the immune response and establish on-going infections. Similarly acute respiratory infection with virulent strains of influenza A virus are often poorly controlled by the immune system and can cause severe immunopathology and even fatality as a result of an inappropriate and excessive inflammatory response called a ‘cytok

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25

Spyer, Moira Jane. "Respiratory syncytial virus host cell receptor interactions." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269926.

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26

Xie, Xiaojian, and 解晓健. "Evaporation and movement of respiratory droplets in indoor environments." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40987802.

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27

Thomas, Linda D., and n/a. "Pseudomonas aeruginosa : development of a mucosal vaccine for respiratory infection." University of Canberra. Human & Biomedical Sciences, 2001. http://erl.canberra.edu.au./public/adt-AUC20061109.130804.

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Pseudomonas aeruginosa (P. aeruginosa) is a frequently isolated pathogen that causes septicaemia and chronic respiratory infection. It exhibits a higher mortality rate than other gram-negative bacteria and the need for effective immunotherapy is emphasised by the frequency of antibiotic resistance associated with this organism. Mucosal immunisation with a whole killed cell P. aeruginosa vaccine has previously demonstrated a significant immune response in both rodent studies and human trials. This study is a continuation of that research, with the major goal being the identification of a purifi

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28

McGill, Alison Kate. "The role of antigenic variation in respiratory syncytial virus infection." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391959.

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SÌarmaÌ„, RaviÌ„ndra. "Immuno-pathogenesis of bovine respiratory syncytial virus infection in lambs." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316908.

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30

Muloiwa, Rudzani. "Epidemiology of pertussis in children hospitalised with respiratory tract infection." Doctoral thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/33846.

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The availability of an effective vaccine against Bordetella pertussis substantially reduced the morbidity and mortality from pertussis, however, in the last decade there appears to have been a substantial increase in pertussis cases as reported mainly in high income countries. Although it is believed that the greatest burden of pertussis, including deaths, is in low- and middle-income countries (LMICs), there seem to be little data available to back this up. This thesis set out to find data that will give some insight into the burden of pertussis in a low- and middle-income setting in infants

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Stokes, A. "Immune effector mechanisms in equine herpesvirus type-1 infection." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233248.

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Juntti, H. (Hanna). "Association of respiratory syncytial virus infection with asthma and atopic allergy." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514287947.

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Abstract Respiratory syncytial virus (RSV) infection may be associated with the development of asthma and atopy. The aim of the present study was to investigate this association and the related immunological mechanisms. Seventy-six children admitted to Oulu University Hospital in 1991–1994 for an RSV infection at an age of less than 12 months and healthy controls were called for a visit at the age of 6–10 years. Twenty subjects (26%) had asthma compared with 12 controls (16%) (difference 11%, 95% confidence interval (CI) –3% to 24%). Asthma had been diagnosed significantly earlier in the subj

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Hayes, Peter John. "The role of macrophages in respiratory syncytial virus infection of mice." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358972.

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Hamal, Giuma Fituri. "Respiratory tract infection in infants and young children with bronchopulmonary dysplasia." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365909.

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Sorensen, George Edwin Peter. "Host-virus interactions in porcine reproductive and respiratory syndrome virus infection." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10040.

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Porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly evolving virus that has significant economic and welfare implications for the pig industry. Vaccination strategies have proved largely ineffective in controlling PRRSV, in some cases even reverting to virulence. An increasing body of evidence suggests a host genetic basis for PRRSV resistance so there is a need to examine the role of host genetics in a biologically relevant in vitro cell culture system. However, PRRSV research is inhibited by the current scarcity of suitable in vitro culture systems. With the aim of devel

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Allman, Mark. "What influences the prescribing of antibiotics in lower respiratory tract infection?" Thesis, University of Bath, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687300.

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Antibiotics are widely prescribed for patients with lower respiratory tract infection (LRTI) yet only a minority have a pneumonia which responds to antibiotic treatment. Unwarranted prescribing of antibiotics is associated with several problems aside from the financial implications of unnecessary treatment: increased incidence of hospital-acquired infections, including MRSA and Clostridium difficile and the problem of antibiotic resistance. The aim of this study was to investigate the influence of the history and examination findings on antibiotic prescribing where LRTI is the principal diagno

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Molina, Barrios Ramón Miguel. "Porcine reproductive and respiratory syndrome virus understanding and managing persistent infection /." [Ames, Iowa : Iowa State University], 2008.

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Schmidt, Megan Elizabeth. "Assessing T cell responses in respiratory syncytial virus infection and vaccination." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6850.

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Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in infants and young children, but no vaccine is currently available. CD4 and CD8 T cells are critical for mediating viral clearance but also contribute to immunopathology following an acute RSV infection. However, few RSV-derived CD4 and CD8 T cell epitopes in the commonly used C57BL/6 mouse strain have been described. I utilized an overlapping peptide library spanning the entire RSV proteome and intracellular cytokine staining for interferon-gamma (IFN-γ) to identify novel CD4 and

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Bustami, Mona Ratib. "Reactive oxygen and nitrogen species in cystic fibrosis." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248100.

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Woensel, Jacobus Bernardus Maria van. "Lower respiratory tract infection caused by respiratory syncytial virus the short-term and long-term efficacy of corticosteroids /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/63898.

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Binns, Sarah Helen. "Studies on the epidemiology of Bordetella bronchiseptica infection in cats." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243267.

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Al, Alwadhi Fahimah Kamil M. R. "Upper respiratory tract infection : implementation of multiple interventions on antibiotic prescribing for patients with upper respiratory tract infection in primary health care settings in United Arab Emirates." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440096.

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Part I. Aims: The aims of part I of this research programme were to: measure the prevalence of antibiotic prescription for U.R.T.I. in Primary Health Care Centres in the United Arab Emirates; understand the rational behind antibiotic prescription; Evaluate the effect of different patient characteristics such as self treatment, age, education, occupation and gender; evaluate the effect of physician characteristics such as gender, communication and practice location; and to evaluate the degree of patient compliance and satisfaction with treatment. Main Conclusions: U.R.T.I. is one of the main

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Ortiguerra, Ryan Gatdula. "Risk Factors Associated With Severe Acute Respiratory Infections Cases." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2749.

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The close proximity of the United States to the Mexican border poses a concern for communicable diseases because of the high flow of population movement. The purpose of this retrospective, quantitative study was to identify risks associated with respiratory diseases using an analysis of archived data from the Severe Acute Respiratory Illness (SARI) surveillance program. Based on the epidemiologic triangle theory, demographic and etiologic factors were analyzed to examine any associations with SARI in this population. Between 2010 and 2012, 798 subjects enrolled in this program, with 336 (42.1%

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Mulpuru, Sunita. "Does Respiratory Viral Testing in Adult Hospitalized Patients Impact Hospital Resource Utilization and Improve Patient Outcomes?" Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31165.

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Respiratory viral testing in hospitalized patients is thought to improve quality of care by reducing the use of diagnostic tests, guiding infection control precautions, and rationalizing antimicrobial therapies. Few small published studies have tested these assumptions, and have demonstrated conflicting results. We conducted a retrospective cohort study of 24,567 hospitalizations using administrative data to determine the associations between viral testing, patient outcomes, and process of care. Viral testing was not associated with improved mortality or length of stay in hospital, and resulte

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Saravanos, Gemma Lea. "Unknowns of Severe Acute Respiratory Infection (SARI) in Australian Children: Enhancing understanding of epidemiology to inform disease prevention." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27237.

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My doctoral research aimed to enhance understanding of the virology and clinical epidemiology of severe acute respiratory infection (SARI) in Australian children to inform disease prevention strategies. I first studied respiratory syncytial virus (RSV), a leading cause of acute lower respiratory infection in young children. Specifically, I aimed to estimate the incidence of respiratory syncytial virus (RSV) hospitalisations in the Australian population, examine the circulation and associated disease severity of RSV subtype infections, determine whether RSV infection contributes to deaths in Au

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West, Keith Henry. "The effect of vaccination on the response to experimental infection with bovine respiratory syncytial virus infection in calves." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ37923.pdf.

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Chauhan, Anoop Jivan. "Personal exposure to the air pollutant nitrogen dioxide and the risk of lower respiratory disease with upper respiratory infection." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266657.

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Davies, Bronwen J. "Physical activity and symptoms of upper respiratory tract infection in university students." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ61257.pdf.

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German, Matthew. "Tissue specific pathology associated with micronutrient supplementation during respiratory syncytial virus infection." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106408.

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Micronutrients are increasingly appreciated as potent immunomodulators. Long used to 'treat' measles virus (MeV), vitamin A was recently shown to act through RIG-I to up-regulate type 1 interferons. Similar actions are seen with some (mumps virus and CDV) but not all members of the Paramyxoviridae. However, children infected with respiratory syncytial virus (RSV), a close relative of MeV, do worse when given pharmacological doses of vitamin A. RSV is known to elicit a pathologic Th2-biased response. Vitamin A also has a strong Th2-deviating influence. Our primary objective was to develop a sma

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Munywoki, Patrick Kiio. "Transmission of respiratory syncytial virus in households : who acquires infection from whom?" Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607465.

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Households represent a setting of frequent and intense contacts and hence are conducive to the spread of respiratory viruses, such as respiratory syncytial virus (RSV). Infants are most vulnerable to severe RSV disease but a vaccine is oat yet available hence the need to explore alternate strategies of protecting them, Such strategies would require better understanding of who infects the infants. During the RSV season of200912010, we undertook a prospective study in rural Kenya involving 493 members of 47 households each with a child born after the preceding RSV epidemic and at least one elder

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