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Artykuły w czasopismach na temat „S100A8”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Mitrović Ajtić, Olivera, Tijana Subotički, Miloš Diklić, et al. "Regulation of S100As Expression by Inflammatory Cytokines in Chronic Lymphocytic Leukemia." International Journal of Molecular Sciences 23, no. 13 (2022): 6952. http://dx.doi.org/10.3390/ijms23136952.

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The calcium-binding proteins S100A4, S100A8, and S100A9 are upregulated in chronic lymphocytic leukemia (CLL), while the S100A9 promotes NF-κB activity during disease progression. The S100-protein family has been involved in several malignancies as mediators of inflammation and proliferation. The hypothesis of our study is that S100A proteins are mediators in signaling pathways associated with inflammation-induced proliferation, such as NF-κB, PI3K/AKT, and JAK/STAT. The mononuclear cells (MNCs) of CLL were treated with proinflammatory IL-6, anti-inflammatory IL-10 cytokines, inhibitors of JAK

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Broome, Ann-Marie, David Ryan, and Richard L. Eckert. "S100 Protein Subcellular Localization During Epidermal Differentiation and Psoriasis." Journal of Histochemistry & Cytochemistry 51, no. 5 (2003): 675–85. http://dx.doi.org/10.1177/002215540305100513.

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S100 proteins are calcium-activated signaling proteins that interact with target proteins to modulate biological processes. Our present studies compare the level of expression, and cellular localization of S100A7, S100A8, S100A9, S100A10, and S100A11 in normal and psoriatic epidermis. S100A7 and S100A11 are present in the basal and spinous layers in normal epidermis. These proteins appear in the nucleus and cytoplasm in basal cells but are associated with the plasma membrane in spinous cells. S100A10 is present in basal and spinous cells, in the cytoplasm, and is associated with the plasma mem

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Peterova, Eva, Jan Bures, Paula Moravkova, and Darina Kohoutova. "Tissue mRNA for S100A4, S100A6, S100A8, S100A9, S100A11 and S100P Proteins in Colorectal Neoplasia: A Pilot Study." Molecules 26, no. 2 (2021): 402. http://dx.doi.org/10.3390/molecules26020402.

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S100 proteins are involved in the pathogenesis of sporadic colorectal carcinoma through different mechanisms. The aim of our study was to assess tissue mRNA encoding S100 proteins in patients with non-advanced and advanced colorectal adenoma. Mucosal biopsies were taken from the caecum, transverse colon and rectum during diagnostic and/or therapeutic colonoscopy. Another biopsy was obtained from adenomatous tissue in the advanced adenoma group. The tissue mRNA for each S100 protein (S100A4, S100A6, S100A8, S100A9, S100A11 and S100P) was investigated. Eighteen biopsies were obtained from the he

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Calaf, Gloria M., Luis N. Ardiles, and Leodan A. Crispin. "Role of Calcium in an Experimental Breast Cancer Model Induced by Radiation and Estrogen." Biomedicines 12, no. 11 (2024): 2432. http://dx.doi.org/10.3390/biomedicines12112432.

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Background: Breast cancer, a global health challenge, significantly impacts women worldwide, causing morbidity, disability, and mortality. Objectives: To analyze the role of genes encoding S100 calcium-binding proteins and their relationship with radiation as possible markers in breast carcinogenesis. Methods: The normal MCF-10F cell line was used to study the role of ionizing radiation and estrogen to induce distinct stages of malignancy giving rise to an in vitro experimental breast cancer model. Results: Analysis of an Affymetrix system revealed that the gene expression levels of the S100 c

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5

Li, Changyou, Siyuan Li, Changkai Jia, Lingling Yang, Zicheng Song, and Yiqiang Wang. "Low Concentration of S100A8/9 Promotes Angiogenesis-Related Activity of Vascular Endothelial Cells: Bridges among Inflammation, Angiogenesis, and Tumorigenesis?" Mediators of Inflammation 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/248574.

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Previous studies showed that several members of the S100A family are involved in neovascularization and tumor development. This study checked whether low concentrations of S100A8 or S100A9 has any effect on the behaviour of vascular endothelial cells. A human umbilical vascular endothelial cell (HUVEC) line was used to measure vascular endothelial cell bioactivity related to angiogenesis, such as cell proliferation, migration, and vessel formation. In the low concentration range up to 10 μg/mL, either each alone or in combination, S100A8 and S100A9 proteins promoted proliferation of HUVEC cell

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6

Wakiya, R., T. Kameda, K. Ueeda, et al. "Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus." Lupus 28, no. 7 (2019): 826–33. http://dx.doi.org/10.1177/0961203319846391.

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Objectives We investigated the effect of hydroxychloroquine (HCQ) on S100A8 and S100A9 serum levels in systemic lupus erythematosus (SLE) patients with low disease activity receiving immunosuppressants. Methods SELENA-SLEDAI, Cutaneous Lupus Erythematous Disease Area and Severity Index (CLASI) and serum levels of complement factors, anti-dsDNA antibodies, and white blood cell, lymphocyte, and platelet counts were used to evaluate disease activity, cutaneous disease activity, and immunological activity, respectively. Serum S100A8 and S100A9 were measured at HCQ administration and after 3 or 6 m

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7

Hu, Shao-yan, Ming-ying Zhang, Shui-yan Wu, et al. "High Transcription Levels Of S100A8 and S100A9 In Acute Myeloid Leukemia Are Predictors For Poor Overall Survival." Blood 122, no. 21 (2013): 2610. http://dx.doi.org/10.1182/blood.v122.21.2610.2610.

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Abstract S100A8 and S100A9 are two members of the S100 calcium-binding protein family, preferentially form functional heterodimers of S100A8/S100A9, and have been increasingly recognized as biomarkers in malignancies. Recent proteomic studies revealed that S100A8 and S100A9 played pivotal roles in hematologic malignancies and elevated expression of S100A8/S100A9 implicated in glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia (ALL). In addition, S100A8 proteomic expression in leukemic cells was reported to predict survival in AML patients. However, information on t

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8

Barabé, Frédéric, Malika Laouedj, and Philippe Tessier. "Myeloid-Related Protein S100A9 Induces Cellular Differentiation in Acute Myeloid Leukemia through TLR2 and TLR4 Receptors." Blood 126, no. 23 (2015): 3858. http://dx.doi.org/10.1182/blood.v126.23.3858.3858.

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Abstract The myeloid-related proteins S100A8 (MRP8) and S100A9 (MRP14) are endogenous alarmins abundantly and constitutively expressed by myeloid cells (neutrophils, monocytes and immature myeloid cells). S100A8 and S100A9 proteins exist as homodimers but also associate to form the heterodimer calprotectin (S100A8/A9) and are up-regulated in several inflammatory diseases and human cancers. In patients with acute myeloid leukemia (AML), the concentration of S100A8/A9 in serum is elevated and the expression of S100A8 correlates with poor prognosis. However, the role of these proteins in hematolo

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9

Jukic, A., R. Hilbe, L. Zundel, et al. "DOP028 The resolution of fecal calprotectin configurations and their biological functions in gut inflammation." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i134. https://doi.org/10.1093/ecco-jcc/jjae190.0067.

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Abstract Background Fecal calprotectin (CP) serves as a worldwide established biomarker used for the diagnosis and management of inflammatory bowel diseases (IBD). However, the biological function of CP in the human gut is still unknown and numerous studies obtained contradictory results. Calprotectin is mainly described to be present as a tetrameric protein complex (S100A8/S100A9)2, while the quaternary protein structure (configuration) of S100A8 and S100A9 in the human gut lumen remains enigmatic.1 In this study we resolved the fecal protein configurations of calprotectin and their biologica

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10

Wolf, Marc, Robiya Joseph, Judith Austermann, et al. "S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of Leukocytes." Biomedicines 11, no. 3 (2023): 835. http://dx.doi.org/10.3390/biomedicines11030835.

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Immune reactions are characterized by the rapid immigration of phagocytes into sites of inflammation. Meticulous regulation of these migratory processes is crucial for preventing uncontrolled and harmful phagocyte extravasation. S100A8/S100A9 is the major calcium-binding protein complex expressed in phagocytes. After release, this complex acts as a proinflammatory alarmin in the extracellular space, but the intracellular functions of these highly abundant proteins are less clear. Results of this study reveal an important role of S100A8/S100A9 in coordinated cytoskeleton rearrangement during mi

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11

Zhang, Yao, Xueyun Zhang, Jiajia Han, et al. "Plasma S100A8 and S100A9 Are Strong Prognostic Factors for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure." Canadian Journal of Gastroenterology and Hepatology 2023 (July 10, 2023): 1–12. http://dx.doi.org/10.1155/2023/6164611.

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Objectives. The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver failure (ACLF) are inseparable from the role of systemic inflammatory response. S100A8 and S100A9 are associated with the excessive cytokine storm and play a decisive part within the process of inflammation. We aimed to clarify the role of them in predicting prognosis of hepatitis B virus-related ACLF (HBV-ACLF). Methods. S100A8 and S100A9 levels were analyzed in plasma of 187 transplant-free HBV-ACLF patients, 28 healthy controls and 40 chronic hepatitis B (CHB) patients. S100A8 and S100A9 mR

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12

Litus, Ekaterina A., Marina P. Shevelyova, Alisa A. Vologzhannikova та ін. "Binding of Pro-Inflammatory Proteins S100A8 or S100A9 to Amyloid-β Peptide Suppresses Its Fibrillation". Biomolecules 15, № 3 (2025): 431. https://doi.org/10.3390/biom15030431.

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Human serum albumin (HSA) is a natural depot of amyloid-β peptide (Aβ), a key player in Alzheimer’s disease (AD). HSA and pro-inflammatory Ca2+-binding proteins S100A8 and S100A9 are involved in Aβ metabolism and its deposition in the brain, serving as probable triggers and therapeutic targets in AD, but their interplay with regard to Aβ binding/fibrillation is unclear. To this end, here we explore the in vitro binding of Ca2+-bound S100A8 or S100A9 to monomeric Aβ and the influence of the S100 proteins on Aβ fibrillation. The equilibrium dissociation constants of the complexes of dimeric S100

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13

Holmannová, Drahomíra, Barbora Císařová, Pavel Borský, et al. "Goeckerman Regimen Reduces Alarmin Levels and PASI Score in Paediatric Patients with Psoriasis." Acta Medica (Hradec Kralove, Czech Republic) 64, no. 4 (2021): 204–12. http://dx.doi.org/10.14712/18059694.2022.3.

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Background. Psoriasis is a chronic systemic inflammatory disease with (extra-)cutaneous manifestations. Inflammation is associated with cellular stress and tissue damage which lead to the release of alarmins (signals of danger). Goeckerman regimen (GR) is a highly efficacious treatment consisting of the application of pharmaceutical crude tar and UVB light exposure. The reduction of inflammatory processes in the skin is accompanied by changes in the levels of inflammatory markers - alarmins (HMBG-1, S100A7, S1000A8, S100A9, S100A12, IL-17, IL-22, and IL-33). Methods. The alarmin levels in sera

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14

Xia, Pengpeng, Xin Ma, Li Yan, et al. "Generation and Application of Monoclonal Antibodies against Porcine S100A8, S100A9, and S100A12 Proteins Using Hybridoma Technology." International Journal of Molecular Sciences 25, no. 2 (2024): 1029. http://dx.doi.org/10.3390/ijms25021029.

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S100A8, S100A9, and S100A12 proteins are important members of the S100 protein family, act primarily as congenital immunomodulators, and are closely related to the occurrence of infectious diseases. There have been few reports on the functional properties of S100A8, S100A9, and S100A12 proteins in swine, but it is certain that porcine S100A8, S100A9, and S100A12 proteins are highly expressed in diseased swine. To address the current lack of reliable and timely detection tools for these three proteins, we generated monoclonal antibodies specific to the porcine S100A8, S100A9, and S100A12 protei

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Thurainayagam, Sumita, Viktor Wixler, Johannes Roth та Thomas Vogl. "Recovery of S100A8 in the absence of S100A9 exacerbates TNFα-mediated psoriatic-like arthritis (IRC4P.462)". Journal of Immunology 194, № 1_Supplement (2015): 57.15. http://dx.doi.org/10.4049/jimmunol.194.supp.57.15.

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Abstract Psoriasis is a chronic autoimmune disorder and frequently associated with arthritis (PsA). Alarmins S100A8 and S100A9, expressed in granulocytes, monocytes and activated keratinocytes, are highly up-regulated in psoriatic skin and synovium. Although S100a8 mRNA remains unchanged in S100A9-deficient (S100A9-/-) mice, S100A8 protein expression is abrogated, thus generating a functionally double knockout mouse model. In general, S100A9-/- mice show reduced inflammatory activities in several mouse models of infection and inflammation. Recently, we generated ihTNFtgxS100A9-/- mice by cross

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16

Ji, Xiaoyi, Chunhua Nie, Yuan Yao, Yu Ma, Huafei Huang, and Chuangli Hao. "S100A8/9 modulates perturbation and glycolysis of macrophages in allergic asthma mice." PeerJ 12 (April 18, 2024): e17106. http://dx.doi.org/10.7717/peerj.17106.

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Background Allergic asthma is the most prevalent asthma phenotype and is associated with the disorders of immune cells and glycolysis. Macrophages are the most common type of immune cells in the lungs. Calprotectin (S100A8 and S100A9) are two pro-inflammatory molecules that target the Toll-like receptor 4 (TLR4) and are substantially increased in the serum of patients with severe asthma. This study aimed to determine the effects of S100A8/A9 on macrophage polarization and glycolysis associated with allergic asthma. Methods To better understand the roles of S100A8 and S100A9 in the pathogenesis

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Stewart, Helen J. S., Sabah Chaudry, Asante Crichlow, Freya Luiling Feilding, and Timothy J. T. Chevassut. "BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death." Bone Marrow Research 2018 (May 31, 2018): 1–9. http://dx.doi.org/10.1155/2018/5742954.

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S100A8 and S100A9 are both members of the S100 family and have been shown to play roles in myeloid differentiation, autophagy, apoptosis, and chemotherapy resistance. In this study we demonstrate that the BET-bromodomain inhibitor JQ1 causes rapid suppression of S100A8 and S100A9 mRNA and protein in a reversible manner. In addition, we show that JQ1 synergises with daunorubicin in causing AML cell death. Daunorubicin alone causes a dose- and time-dependent increase in S100A8 and S100A9 protein levels in AML cell lines which is overcome by cotreatment with JQ1. This suggests that JQ1 synergises

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Van Crombruggen, Koen, Thomas Vogl, Claudina Pérez-Novo, Gabriele Holtappels, and Claus Bachert. "Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue." European Respiratory Journal 47, no. 1 (2015): 264–74. http://dx.doi.org/10.1183/13993003.00159-2015.

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Intracellular Ca2+-binding S100A8/A9 proteins gain novel functions when released during inflammation. The exact outcome of their extracellular function depends on the local tissue environment in which they are released; both anti-inflammatory and pro-inflammatory responses are described, modulating the immune system by binding Toll-like receptor (TLR)-4 or the receptor for advanced glycation end-products (RAGE). However, the contribution of the proteins in the pathophysiology of chronic rhinosinusitis (CRS) remains unclear.Homomeric S100A8 and S100A9, and heteromeric S100A8/A9 proteins were ev

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Landers-Ramos, Rian Q., Ryan M. Sapp, Emily VandeWater, et al. "Investigating the extremes of the continuum of paracrine functions in CD34−/CD31+ CACs across diverse populations." American Journal of Physiology-Heart and Circulatory Physiology 312, no. 1 (2017): H162—H172. http://dx.doi.org/10.1152/ajpheart.00342.2016.

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Paracrine function of circulating angiogenic cells (CACs) is thought to contribute to vascular maintenance. We previously identified S100A8 and S100A9 secreted from physically inactive individuals’ CD34–/CD31+ CACs as negative regulators of capillary-like network formation. The purpose of this study was to investigate further the extremes of the continuum of CAC paracrine actions using two distinctly different groups representing “healthy” and “impaired” CAC function. We aimed to determine how capillary-like network formation in human umbilical vein endothelial cells (HUVECs) is affected by S1

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Leukert, Nadja, Clemens Sorg, and Johannes Roth. "Molecular basis of the complex formation between the two calcium-binding proteins S100A8 (MRP8) and S100A9 (MRP14)." Biological Chemistry 386, no. 5 (2005): 429–34. http://dx.doi.org/10.1515/bc.2005.051.

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Abstract S100 proteins form characteristic homo- and/or heterodimers that play a role in calcium-mediated signaling. We characterized the formation of the human S100A8/S100A9 heterodimer using the yeast two-hybrid system. Employing site-directed mutagenesis we found that distinct hydrophobic amino acids of helix I/I′ are located at a crucial site of the S100A8/S100A9 dimer interface, whereas conserved residues within helix IV/IV′ are not important for heterodimerization. Furthermore, amino acids Y16 and F68 prevent homodimerization of human S100A8. These data demonstrate for the first time the

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Villodre, Emilly S., Xiaoding Hu, Juhee Song, et al. "Abstract P3-05-22: Serum S100A8/S100A9 levels are associated with increased risk of brain metastasis in patients with aggressive breast cancer." Cancer Research 83, no. 5_Supplement (2023): P3–05–22—P3–05–22. http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-05-22.

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Abstract Background: Inflammatory breast cancer (IBC) is a rare and extremely aggressive form of breast cancer with an increased propensity to disseminate to distant organs such as the brain; indeed, a previous study reported that 37% of patients with HER2+ IBC present with brain metastasis as the first site of relapse. Our group recently generated new sublines from HER2+ IBC that exhibited a high brain metastatic propensity and further demonstrated that the stress response protein N-myc downstream regulated gene 1 (NDRG1) is a driver of breast cancer brain metastasis. Transcriptome analysis c

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Geven, Edwin J. W., den Bosch Martijn H. J. van, Ceglie Irene Di, et al. "S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis." Arthritis Research & Therapy 18, no. 1 (2016): 247. https://doi.org/10.1186/s13075-016-1121-z.

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<strong>Background: </strong>Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is released by activated phagocytes, and high levels are found in seronegative arthritides. In this study, we investigated the biomarker potential of systemic and local levels of these S100 proteins to assess joint inflammation and joint destruction in an experimental model for seronegative arthritis.<strong>Methods: </strong>Serum levels of S100A8/A9 and various cyto

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Wen, Liting, Yu Ding, Xiaodong Chen, et al. "Influences of S100A8 and S100A9 on Proliferation of Nasopharyngeal Carcinoma Cells through PI3K/Akt Signaling Pathway." BioMed Research International 2021 (September 24, 2021): 1–7. http://dx.doi.org/10.1155/2021/9917365.

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Objective. To investigate the effects of S100A8 and S100A9 on proliferation in nasopharyngeal carcinoma cells and the regulatory effects of PI3K/Akt signaling pathway. Methods. Nasopharyngeal carcinoma cells (CNE1) were cultured and randomly divided into three groups: control group, S100A8/S100A9 overexpression group, and siRNA S100A8/S100A9 group. CCK-8 method was used to detect the effect of S100A8 and S100A9 on the viability of nasopharyngeal carcinoma cells. The effects of S100A8 and S100A9 on the colony forming ability of nasopharyngeal carcinoma cells were detected by colony forming assa

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Schiopu, Alexandru, and Ovidiu S. Cotoi. "S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease." Mediators of Inflammation 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/828354.

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Amplification of innate immune responses by endogenous danger-associated molecular patterns (DAMPs) promotes inflammation. The involvement of S100A8 and S100A9, DAMPs belonging to the S100 calgranulin family, in the pathogenesis of cardiovascular disease is attracting an increasing amount of interest. S100A8 and S100A9 (also termed MRP8 and MRP14) preferentially form the S100A8/A9 heterodimer (MRP8/14 or calprotectin) and are constitutively expressed in myeloid cells. The levels of circulating S100A8/A9 in humans strongly correlate to blood neutrophil counts and are increased by traditional ca

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Serhal, Rim, George Hilal, George Boutros, et al. "Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/850246.

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Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevat

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Boucher, Julien, Caroline Gilbert, Santanu Bose, and Philippe A. Tessier. "S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation." Journal of Immunology 212, no. 10 (2024): 1523–29. http://dx.doi.org/10.4049/jimmunol.2300640.

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Abstract The study of S100A9 in viral infections has seen increased interest since the COVID-19 pandemic. S100A8/A9 levels were found to be correlated with the severity of COVID-19 disease, cytokine storm, and changes in myeloid cell subsets. These data led to the hypothesis that S100A8/A9 proteins might play an active role in COVID-19 pathogenesis. This review explores the structures and functions of S100A8/9 and the current knowledge on the involvement of S100A8/A9 and its constituents in viral infections. The potential roles of S100A9 in SARS-CoV-2 infections are also discussed.

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Razmkhah, Farnaz, Sena Kim, Sora Lim, Abdul-Jalil Dania, and Jaebok Choi. "S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy." International Journal of Molecular Sciences 24, no. 17 (2023): 13382. http://dx.doi.org/10.3390/ijms241713382.

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S100A8 and S100A9 are multifunctional proteins that can initiate various signaling pathways and modulate cell function both inside and outside immune cells, depending on their receptors, mediators, and molecular environment. They have been reported as dysregulated genes and proteins in a wide range of cancers, including hematologic malignancies, from diagnosis to response to therapy. The role of S100A8 and S100A9 in hematologic malignancies is highlighted due to their ability to work together or as antagonists to modify cell phenotype, including viability, differentiation, chemosensitivity, tr

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Li, Yulin, Boya Chen, Xinying Yang, et al. "S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury." Circulation 140, no. 9 (2019): 751–64. http://dx.doi.org/10.1161/circulationaha.118.039262.

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Background: Myocardial ischemia-reperfusion (MI/R) injury is a significant clinical problem without effective therapy. Unbiased omics approaches may reveal key MI/R mediators to initiate MI/R injury. Methods: We used a dynamic transcriptome analysis of mouse heart exposed to various MI/R periods to identify S100a8/a9 as an early mediator. Using loss/gain-of-function approaches to understand the role of S100a8/a9 in MI/R injury, we explored the mechanisms through transcriptome and functional experiment. Dynamic serum S100a8/a9 levels were measured in patients with acute myocardial infarction be

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Zhou, Yang, Justine Hann, Véronique Schenten, et al. "Role of S100A8/A9 for Cytokine Secretion, Revealed in Neutrophils Derived from ER-Hoxb8 Progenitors." International Journal of Molecular Sciences 22, no. 16 (2021): 8845. http://dx.doi.org/10.3390/ijms22168845.

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S100A9, a Ca2+-binding protein, is tightly associated to neutrophil pro-inflammatory functions when forming a heterodimer with its S100A8 partner. Upon secretion into the extracellular environment, these proteins behave like damage-associated molecular pattern molecules, which actively participate in the amplification of the inflammation process by recruitment and activation of pro-inflammatory cells. Intracellular functions have also been attributed to the S100A8/A9 complex, notably its ability to regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation. However, the co

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Joshi, Abhishek, Lukas E. Schmidt, Sean A. Burnap, et al. "Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity." Arteriosclerosis, Thrombosis, and Vascular Biology 42, no. 1 (2022): 49–62. http://dx.doi.org/10.1161/atvbaha.121.317113.

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Objective: Platelets are central to acute myocardial infarction (MI). How the platelet proteome is altered during MI is unknown. We sought to describe changes in the platelet proteome during MI and identify corresponding functional consequences. Approach and Results: Platelets from patients experiencing ST-segment–elevation MI (STEMI) before and 3 days after treatment (n=30) and matched patients with severe stable coronary artery disease before and 3 days after coronary artery bypass grafting (n=25) underwent quantitative proteomic analysis. Elevations in the proteins S100A8 and S100A9 were de

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Takagi, Ryosuke, Eijiro Sakamoto, Jun-ichi Kido, et al. "S100A9 Increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-Like Cells." BioMed Research International 2020 (February 20, 2020): 1–12. http://dx.doi.org/10.1155/2020/7149408.

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Objective. Calprotectin is a heterocomplex of S100A8 and S100A9 and is mainly secreted from neutrophils, monocytes, and chondrocytes in inflammatory condition. Calprotectin binds to RAGE and TLR4 and induces the expression of proinflammatory chemokines and cytokines in various cells. Periodontitis is a chronic inflammatory disease that leads to gingival inflammation and alveolar bone resorption. Calprotectin levels in gingival crevicular fluid of periodontitis patients are higher than healthy patients. In the present study, the effects of S100A8 and S100A9 on the expressions of proinflammatory

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Matsuo, Kano, Masaki Ikemoto, and Kohki Okada. "Intraperitoneal Administration of S100A8 Ameliorates Experimental Acute Colitis in Rats." Biology 13, no. 11 (2024): 916. http://dx.doi.org/10.3390/biology13110916.

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S100A8 is a protein that is abundant in neutrophils and macrophages (MΦ), but its role in inflammation remains unclear. This study aimed to assess the immunological role(s) of S100A8 in acute intestinal inflammation in rats and its role in MΦ. Rat recombinant S100A8 (rr-S100A8, 1.0 mg/kg) was intraperitoneally administered daily to rats with 3% dextran sulfate sodium (DSS) (DSS + A8 group)-induced experimental acute colitis. The histological severity score (6.50 ± 0.51, p = 0.038) in the DSS + A8 group rats remained lower than that (9.75 ± 1.48) of the rats without S100A8 (DSS group) administr

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Yano, Junko, Glen E. Palmer, Karen E. Eberle, et al. "Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis." Infection and Immunity 82, no. 2 (2013): 783–92. http://dx.doi.org/10.1128/iai.00861-13.

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ABSTRACTVulvovaginal candidiasis (VVC), caused byCandida albicans, affects women worldwide. Animal and clinical studies suggest that the immunopathogenic inflammatory condition of VVC is initiated by S100 alarmins in response toC. albicans, which stimulate polymorphonuclear neutrophil (PMN) migration to the vagina. The purpose of this study was to extend previousin vitrodata and determine the requirement for the alarmin S100A8 in the PMN response and to evaluate pattern recognition receptors (PRRs) that initiate the response. For the former, PMN migration was evaluatedin vitroorin vivoin the p

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Hagelstein, Jill, Pauline Schneider, Jasper de Boer, et al. "High Expression of the Ca2+-Binding Proteins S100A8 and S100A9 Cause Glucocorticoid Resistance in MLL-Rearranged Infant Acute Lymphoblastic Leukemia." Blood 114, no. 22 (2009): 729. http://dx.doi.org/10.1182/blood.v114.22.729.729.

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Abstract Abstract 729 MLL-rearranged Acute Lymphoblastic Leukemia (ALL) in infants (i.e. children <1 year of age) represents an aggressive and difficult to treat type of leukemia, displaying cellular resistance to several chemotherapeutics, especially to glucocorticoids like prednisolone. As prednisolone response is highly predictive for clinical outcome, it is of utmost importance to unravel the mechanism underlying resistance to this drug. To gain insights in the prednisolone resistance mechanism, we compared gene expression profiles (Affymetrix HU133plus2) from prednisolone-resistant and

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Argyris, P. P., Z. M. Slama, K. F. Ross, A. Khammanivong, and M. C. Herzberg. "Calprotectin and the Initiation and Progression of Head and Neck Cancer." Journal of Dental Research 97, no. 6 (2018): 674–82. http://dx.doi.org/10.1177/0022034518756330.

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Calprotectin (S100A8/A9), a heterodimeric complex of calcium-binding proteins S100A8 and S100A9, is encoded by genes mapping to the chromosomal locus 1q21.3 of the epidermal differentiation complex. Whereas extracellular calprotectin shows proinflammatory and antimicrobial properties by signaling through RAGE and TLR4, intracytoplasmic S100A8/A9 appears to be important for cellular development, maintenance, and survival. S100A8/A9 is constitutively expressed in myeloid cells and the stratified mucosal epithelia lining the oropharyngeal and genitourinary mucosae. While upregulated in adenocarci

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Zou, Xianqiong, Brent S. Sorenson, Karen F. Ross, and Mark C. Herzberg. "Augmentation of Epithelial Resistance to Invading Bacteria by Using mRNA Transfections." Infection and Immunity 81, no. 11 (2013): 3975–83. http://dx.doi.org/10.1128/iai.00539-13.

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ABSTRACTTo protect against invading bacteria, oral epithelial cells appear to use two effector antimicrobial peptides (AMPs): calprotectin (S100A8-S100A9 heterodimer [S100A8/A9]) in the cytosol and cathelicidin antimicrobial protein (CAMP) in endosomes. We sought to learn whether innate immunity might be augmented benignly to increase resistance against invasive bacteria. Epithelial cells were transiently transfected with mRNA constructs containing either theCAMP,S100A8, andS100A9open reading frames,A8-IRES-A9(fusion sequence), orA8-nIRES-A9(fusion with native internal ribosome entry site [IRE

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Tardif, Mélanie R., Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, and Philippe A. Tessier. "Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux." Journal of Immunology Research 2015 (2015): 1–16. http://dx.doi.org/10.1155/2015/296149.

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S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases. These cytoplasmic proteins are secreted by neutrophils at sites of inflammation via alternative secretion pathways of which little is known. This study examined the nature of the stimuli leading to S100A8/A9 and S100A12 secretion as well as the mechanism involved in this alternative secretion pathway. Chemotactic agents, cytokines, and particulate molecules were used to stimulate human neutrophils. MSU crystals, PMA, and H2O2induc

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Wang, Jia-Song, Zhao Zhao, Chao Wang, Hua-Tao Xie, and Ming-Chang Zhang. "Differential expression of antimicrobial peptides in human fungal keratitis." International Journal of Ophthalmology 16, no. 10 (2023): 1630–35. http://dx.doi.org/10.18240/ijo.2023.10.11.

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AIM: To analyze a series of antimicrobial peptides (AMPs) in corneal tissue from individuals with fungal keratitis (FK) during the active phase of the fungus infection and after healing. METHODS: Patients undergone lamellar keratoplasty for the treatment of severe FK or corneal scar had their corneal buttons sampled. Quantitative real-time polymerase chain reaction (PCR) was used to ascertain the gene expression of human beta-defensin (HBD)-1, -2, -3, -9, S100A7, 8, 9, and LL-37. RESULTS: All AMPs’ messenger ribonucleic acid (mRNA) expression was considerably elevated in all samples (n=12). In

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RAM SUDHAN S, MuthuKumar Subramanian, Rajkumar V, Fardeen Shariff, Linish Baalan R, and Sharat Balemane. "Systemic Juvenile Idiopathic Arthritis and arthralgia - can it be diagnosed early within the window period? – An observation of serum biomarkers and analysis with other differential conditions in children." JOURNAL OF THE BULGARIAN ORTHOPAEDICS AND TRAUMA ASSOCIATION 61, no. 4 (2024): 191–201. http://dx.doi.org/10.58542/jbota.v61i4.138.

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Background: Systemic juvenile idiopathic arthritis (sJIA)is a cause of persisting arthralgia which is often missed. Diagnosing sJIA can be challenging, especially when overt arthritis is absent at presentation, highlighting the need for a diagnostic biomarker. Few recent studies have assessed potential biomarkers for sJIA, however, there is no consensus in detecting early. We conducted a study evaluating serum IL-1, IL-6, IL-18, S100A8, and S100A9 as potential diagnostic markers to distinguish sJIA from other conditions presenting as joint pain in children. Methods: A prospective study was con

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Moravkova, Paula, Darina Kohoutova, Jaroslava Vavrova, and Jan Bures. "Serum S100A6, S100A8, S100A9 and S100A11 proteins in colorectal neoplasia: results of a single centre prospective study." Scandinavian Journal of Clinical and Laboratory Investigation 80, no. 3 (2019): 173–78. http://dx.doi.org/10.1080/00365513.2019.1704050.

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Moravkova, Paula, Darina Kohoutova, Jaroslava Vávrová, and Jan Bures. "Tu1943 - Serum S100A6, S100A8, S100A9 and S100A11 in Colorectal Neoplasia: Results of a Single Centre Prospective Study." Gastroenterology 154, no. 6 (2018): S—1060—S—1061. http://dx.doi.org/10.1016/s0016-5085(18)33546-7.

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Mondet, Julie, Simon Chevalier, and Pascal Mossuz. "Pathogenic Roles of S100A8 and S100A9 Proteins in Acute Myeloid and Lymphoid Leukemia: Clinical and Therapeutic Impacts." Molecules 26, no. 5 (2021): 1323. http://dx.doi.org/10.3390/molecules26051323.

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Deregulations of the expression of the S100A8 and S100A9 genes and/or proteins, as well as changes in their plasma levels or their levels of secretion in the bone marrow microenvironment, are frequently observed in acute myeloblastic leukemias (AML) and acute lymphoblastic leukemias (ALL). These deregulations impact the prognosis of patients through various mechanisms of cellular or extracellular regulation of the viability of leukemic cells. In particular, S100A8 and S100A9 in monomeric, homodimeric, or heterodimeric forms are able to modulate the survival and the sensitivity to chemotherapy

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Guo, Li, Ben Berger, Jesse W. Rowley, et al. "Increased Platelet S100A8/S100A9 Associated with Vasculitis in Granulomatosis with Polyangiitis (GPA)." Blood 138, Supplement 1 (2021): 3142. http://dx.doi.org/10.1182/blood-2021-152291.

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Abstract Granulomatosis with polyangiitis (GPA), formerly known as Wegener's Granulomatosis, is characterized by vasculitis that predominantly affects small- and medium-sized blood vessels in the sinuses, lungs, and kidneys. In addition to vascular inflammation, GPA is also characterized by an increased risk of thrombosis. The role of platelets in GPA pathogenesis remains incompletely understood. We aimed to better understand the changes in platelet gene expression and function in patients with GPA. Forty-two patients diagnosed with GPA (n=9 with active GPA and n=33 with GPA in remission) and

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Crombruggen, Koen, Gabriele Holtappels, Thomas Vogl, and Claus Bachert. "S100A8, S100A9 and S100A8/9 in Chronic Rhinosinusitis with Nasal Polyps." Annals of Paediatric Rheumatology 1 (2012): 17. http://dx.doi.org/10.5455/apr.20121129010017.

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Leach, Steven T., Hazel M. Mitchell, Carolyn L. Geczy, Philip M. Sherman, and Andrew S. Day. "S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa ofHelicobacter Pylori-Infected Children." Canadian Journal of Gastroenterology 22, no. 5 (2008): 461–64. http://dx.doi.org/10.1155/2008/308942.

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The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal andHelicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed inH pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth.

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Zhang, Zhenxing, Xiangying Chen, Yong Meng, et al. "Up-Regulation of S100A8 and S100A9 in Pulmonary Immune Response Induced by a Mycoplasma capricolum subsp. capricolum HN-B Strain." Animals 14, no. 14 (2024): 2064. http://dx.doi.org/10.3390/ani14142064.

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Mycoplasma capricolum subsp. capricolum (Mcc), a member of the Mycoplasma mycoides cluster, has a negative impact on the goat-breeding industry. However, little is known about the pathogenic mechanism of Mcc. This study infected mice using a previously isolated strain, Mcc HN-B. Hematoxylin and eosin staining, RNA sequencing, bioinformatic analyses, RT-qPCR, and immunohistochemistry were performed on mouse lung tissues. The results showed that 235 differentially expressed genes (DEGs) were identified. GO and KEGG enrichment analyses suggested that the DEGs were mainly associated with immune re

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Cao, Junjie, Meifeng Xu, Longfei Zhu, and Shengxiang Xiao. "Viaminate Inhibits Propionibacterium Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade." Current Drug Targets 24, no. 13 (2023): 1055–65. http://dx.doi.org/10.2174/0113894501243867230928115205.

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Background: Viaminate, a vitamin A acid drug developed in China, has been clinically used in acne treatment to regulate epithelial cell differentiation and proliferation, inhibit keratinization, reduce sebum secretion, and control immunological and anti-inflammatory actions; however, the exact method by which it works is unknown. Methods: In the present study, acne was induced in the ears of rats using Propionibacterium acnes combined with sebum application Results: After 30 days of treatment with viaminate, the symptoms of epidermal thickening and keratin overproduction in the ears of rats we

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Stepanov, Alexander, Svetlana A. Usharova, Kristina A. Malsagova, et al. "Tear Proteome Revealed Association of S100A Family Proteins and Mesothelin with Thrombosis in Elderly Patients with Retinal Vein Occlusion." International Journal of Molecular Sciences 23, no. 23 (2022): 14653. http://dx.doi.org/10.3390/ijms232314653.

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Tear samples collected from patients with central retinal vein occlusion (CRVO; n = 28) and healthy volunteers (n = 29) were analyzed using a proteomic label-free absolute quantitative approach. A large proportion (458 proteins with a frequency > 0.6) of tear proteomes was found to be shared between the study groups. Comparative proteomic analysis revealed 29 proteins (p < 0.05) significantly differed between CRVO patients and the control group. Among them, S100A6 (log (2) FC = 1.11, p < 0.001), S100A8 (log (2) FC = 2.45, p < 0.001), S100A9 (log2 (FC) = 2.08, p < 0.001), and mes

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Passey, Robert J., Elizabeth Williams, Agnieszka M. Lichanska, et al. "A Null Mutation in the Inflammation-Associated S100 Protein S100A8 Causes Early Resorption of the Mouse Embryo." Journal of Immunology 163, no. 4 (1999): 2209–16. http://dx.doi.org/10.4049/jimmunol.163.4.2209.

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Abstract S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is expressed together with its dimerization partner S100A9 during myelopoiesis in the fetal liver and in adult bone marrow as well as in mature granulocytes. In this paper we show that S100A8 mRNA is expressed without S100A9 mRNA between 6.5 and 8.5 days postcoitum within fetal cells infiltrating the deciduum in the vicinity of the ectoplacental cone. Targeted disruption of the S100A8 gene caused rapid and synchronous embryo resorp

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McLachlan, Julia L., Alastair J. Sloan, Anthony J. Smith, Gabriel Landini, and Paul R. Cooper. "S100 and Cytokine Expression in Caries." Infection and Immunity 72, no. 7 (2004): 4102–8. http://dx.doi.org/10.1128/iai.72.7.4102-4108.2004.

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ABSTRACT The molecular immune response of the pulpal tissue during chronic carious infection is poorly characterized. Our objective was to examine the expression of potential molecular mediators of pulpal inflammation, correlate their levels with disease severity, and determine the cellular localization of key molecules. Results indicated that there was significantly increased transcriptional activity in carious compared to healthy pulp, and the increase correlated positively with disease severity. Semiquantitative reverse transcriptase PCR analysis in 10 carious and 10 healthy pulpal tissue s

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