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Data publikacji: 6 września 2023
Data aktualizacji: 7 września 2023

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1

Rowley, Neil K. "Studies on the Saccharomyces cerevisiae genome." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361615.

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Greig, Duncan. "Sex, species and Saccharomyces cerevisiae." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301401.

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Novarina, D. "MECHANISMS PRESERVING GENOME INTEGRITY IN SACCHAROMYCES CEREVISIAE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/215589.

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The integrity of the genome is continuously jeopardized by endogenous reactive byproducts of cellular metabolism and genotoxic insults by environmental agents, as well as by the DNA transactions (replication, transcription and recombination) required for cell survival and proliferation. Failure of the mechanisms deputed to the maintenance of genome integrity leads to genome instability, which is a hallmark of cancer and a driving force of tumorigenesis. To fully understand the mechanisms leading to genome instability and the cellular pathways counteracting them, three basic tasks must be achie
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SHANMUGAN, MUTHU KUMAR. "EXPLORING GENOME INTEGRITY PATHWAYS IN SACCHAROMYCES CEREVISIAE." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229912.

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Genomic DNA is under constant attack from both endogenous and exogenous DNA damaging agents like reactive oxygen species which include O2, H2O2, OH, reactive carbonyl species, alkylating agents such as estrogen and cholesterol metabolites, radiations (like UV, x-rays and gamma rays) and mutagenic chemicals. Moreover, threats to DNA integrity can also come from DNA metabolism such as replication, transcription and recombination. In order to survive and faithfully transmit the genetic material to the progeny, cells must detect the damage and activate repair mechanisms and, if the damage cannot b
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5

Bleackley, Mark Robert. "Transition metal tolerance and the Saccharomyces cerevisiae genome." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/30821.

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Transition metal ions are essential nutrients to all forms of life. Iron, copper, zinc, manganese, cobalt and nickel all have unique chemical and physical properties that make them attractive molecules for use in biological systems. Many of these same properties that allow these metals to provide essential biochemical activities and structural motifs to a multitude of proteins including enzymes and other cellular constituents also leads to a potential for cytotoxicity. Organisms have been required to evolve a number of systems for the efficient uptake, intracellular transport, protein loadi
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Minchell, Nicola E. "DNA topological stress during DNA replication in Saccharomyces cerevisiae." Thesis, University of Sussex, 2019. http://sro.sussex.ac.uk/id/eprint/81222/.

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DNA topological stress impedes normal DNA replication. If topological stress is allowed to build up in front of the replication fork, the fork rotates to overcome the stress, leading to formation of DNA pre-catenanes. The formation of DNA pre-catenanes is therefore a marker of DNA topological stress. In this study, I have examined how transcription linked DNA topological stress impacts on fork rotation and on endogenous DNA damage. Transcription, similar to replication, affects the topology of the DNA; and collision between the two machineries is likely to lead to high levels of DNA topologica
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7

Cook, Kristen. "Regulation of Genome-Wide Transcriptional Stress Responses in Saccharomyces cerevisiae." Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10032.

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In response to osmotic shock in Saccharomyces cerevisiae the MAP kinase Hog1 coordinates a large-scale transcriptional stress response, rapidly producing hundreds of copies of specified transcripts. Many of the most highly induced genes are bound and regulated by a transcription factor, Sko1, but lack the canonical binding site for this factor. We use ChIP-seq to demonstrate a stress-specific binding mode of Sko1. In stress, Sko1 binds to promoters in close proximity to Hog1, and another Hog1-regulated transcription factor, Hot1. This mode of Sko1 binding requires the physical presence of
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8

Coissac, Éric. "Analyse structurale et fonctionnelle du genome de la levure saccharomyces cerevisiae." Paris 6, 1996. http://www.theses.fr/1996PA066520.

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Dans le cadre d'une collaboration internationale, la sequence nucleotidique du genome de la levure saccharomyces cerevisiae a ete entierement determinee. Au sein de ce projet, nous avons sequence un fragment d'adn de 39411 paires de bases correspondant aux regions telomerique et subtelomerique gauches du chromosome vii. Cette region comporte dix-huit phases ouvertes de lectures longues de plus de cent codons et une de soixante-seize. Parmi elles, six correspondent a des genes precedemment identifies : adh4, fzf1, hxk2, rtg2, hfm1 et pde1. La deletion de cinq autres a ete realisee (ygl257c, ygl
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9

Teixeira, Maria Teresa. "Organisation du noyau et analyse fonctionnelle du genome de saccharomyces cerevisiae." Paris 11, 2000. http://www.theses.fr/2000PA112033.

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La structure du noyau semble etre hautement organisee : de nombreux facteurs nucleaires sont adresses a des domaines discrets, en concordance avec leur role localise. Cette regionalisation spatiale et fonctionnelle est particulierement bien etablie dans le cas du nucleole, site d'assemblage des sous-unites ribosomiques et dans le cas du pore nucleaire, site du trafic nucleo-cytoplasmique. Ce travail de these a pour but de participer a la caracterisation moleculaire de certains constituants du noyau impliques dans cette organisation fonctionnelle en prenant comme modele experimental la levure s
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10

Amai, Takamitsu. "Development of genome editing technology of mitochondrial DNA in Saccharomyces cerevisiae." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263707.

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11

Powers, Ralph Wilson. "Genome-wide screens reveal that reduced TOR signaling extends chronological and replicative life span in S. cerevisiae /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5044.

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12

Leadbitter, Matthew. "Genome-wide study to investigate the organisation of global genome nucleotide excision repair in Saccharomyces cerevisiae." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/54442/.

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In <italic>Saccharomyces cerevisiae</italic> efficient global genome nucleotide excision repair (GGR) requires a heterotrimeric protein complex of Abfl, Rad7 and Radl6 termed the GGR complex. Abfl is a site specific DNA binding protein with known roles in DNA replication, transcription and repair. Radl6 has a DNA translocase activity and is a functional component of an E3 ubiquitin ligase. Radl6 has recently been shown to regulate the occupancy of Gcn5 and histone H3 K9K14 acetylation in response to UV damage. The current study investigates how GGR is organised throughout the genome using chro
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13

Driscoll, R. "Saccharomyces cerevisiae proteins Rtt109p and Esc2p : two novel regulators of genome stability." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598656.

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I reveal that <i>Saccharomyces cerevisiae</i> Rtt109p promotes genome stability and resistance to DNA-damaging agents, and that it does this by functionally cooperating with the histone chaperone Asf1p to maintain normal chromatin structure. Furthermore, I show that, as for Asf1p, Rtt109p is required for histone H3 acetylation on lysine 56 (K56) <i>in vivo</i>. Moreover I show that Rtt109p directly catalyzes this modification <i>in vitro</i> in a manner that is stimulated by Asf1p. These data establish Rtt109p as a member of a new class of histone acetyltransferases and show that its actions a
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14

Huang, Meng-Er. "Contribution a l'etude du genome de la levure saccharomyces cerevisiae : chromosome 10." Paris 7, 1993. http://www.theses.fr/1993PA077268.

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Ce travail a ete effectue dans le cadre d'un programme de la communaute europeenne. Il comprend trois parties: 1) construction d'un contig du chromosome x de s. Cerevisiae, 2) sequencage du fragment de 41 kb, 3) analyse de la sequence de ce fragment. Un contig de 250 clones recombinants contenant l'adn du chromosome x a ete assemble en progressant a l'aide de ribosondes t3 et t7. Sa validite a ete confirmee par diverses approches. Une carte de restriction ecori de l'ensemble du contig a ete etablie. Un fragment de 41 kb a ete sequence en utilisant une methode aleatoire de fractionnement a l'ai
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15

PORCU, GIAMPIERO. "Genome wide analysis of effects of protein farnesylation inhibition on saccharomyces cerevisiae." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/559.

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Farmaci anticancro basati sull’inibizione della farnesil-transferasi (FTIs) sono in grado di inibire la prenilazione di Ras e la crescita tumorale in un gran numero di tumori, come evidenziato durante gli studi preclinici. Tuttavia, se testati in studi clinici, gli FTIs hanno dimostrato di avere effetti anti-tumorali solo se usati in combinazione con altri farmaci. Nonostante una decade di studi, il meccanismo d’azione tramite cui gli FTIs agiscono sulle cellule tumorali rimane sconosciuto, tanto più che è evidente che tali farmaci agiscono su molteplici vie e varie proteine prenilate oltre a
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16

Lantermann, Alexandra. "Comparison of Genome-Wide Nucleosome Positioning Mechanisms in Schizosaccharomyces pombe and Saccharomyces cerevisiae." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-118784.

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17

Pegram, Kirsty Elizabeth. "The role of FOB 1 sumoylation in maintaining genome stability in saccharomyces cerevisiae." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528293.

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18

Garduño, Bertha Veronića. "Cbf1 regulates chromatin remodelling of the Saccharomyces cerevisiae genome at multiple binding sites." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:be76ba21-1336-4ac8-9da3-918fd58d5908.

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The centromere binding factor 1, Cbf1, of Saccharomyces cerevisiae is a bHLH/ZIP protein which has been described as a determinant of specific chromatin structures and as a tethering factor for activators of transcription at the promoters of genes of the Methionine Biosynthesis Pathway. Deletion mutants show various phenotypes, among them methionine auxotrophy, an increased rate of chromosome loss, modifications in the growth rate and modification of the chromatin structure at MET genes. Meiosis competence also becomes greatly reduced in cbf1 cells. The sequence motif (RTCACRTG) to which Cbf1p
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19

Jennings, Ezra (Ezra Gray) 1971. "Genome-wide expression and location profiling in Saccharomyces cerevisiae : experimental and graphical analysis." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/29919.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2002.<br>Includes bibliographical references.<br>Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific t
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20

Hui, Sheng. "The analysis of metabolism in saccharomyces cerevisiae with genome-scale gene expression data." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/640.

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21

Ojo, Tolulope A. "Characterization of new mutants in the 16S ribosomal subunit region of the mitochondrial genome of Saccharomyces cerevisiae /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2006/148.pdf.

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22

Lévesque, Nancy. "Deciphering the function of chromatin modifiers in genome regulation and maintenance in Saccharomyces cerevisiae." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43352.

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Chromatin is a dynamic structure that facilitates DNA compaction inside the cell nucleus and contributes nuclear process regulation such as transcription, DNA repair and DNA replication. Chromatin structure can be modified by several mechanisms, including the incorporation of histone variants, histone sliding or removal by ATP-dependent remodelling enzymes, addition of post-translational modifications, and addition of methylation marks on DNA. This dissertation aims to comprehend better the role of chromatin modifiers like histone acetyltransferases (HATs) in cellular processes such as genome
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23

Harris, M. R. "G1/S transcriptional regulation in Saccharomyces cerevisiae integrates cell cycle progression and genome stability." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419003/.

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Saccharomyces cerevisiae provides an ideal model to study the regulation of cell cycle commitment due to the high conservation of signalling pathways and regulatory modules through to higher eukaryotes. My work investigates the interplay of cell cycle progression and arrest via the action of transcription factor regulation. Cell cycle commitment is controlled by the cyclin-dependent activation of transcription factor complexes, MBF and SBF. Here I describe the dynamics of SBF and MBF using new polyclonal anti-sera against the three key components Mbp1, Swi4 and Swi6, and their interaction with
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24

MAFTAHI, MOHAMED. "Contribution au sequencage et a l'analyse fonctionnelle du genome de la levure saccharomyces cerevisiae." Paris 7, 1997. http://www.theses.fr/1997PA077134.

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La levure saccharomyces cerevisiae represente le premier organisme eucaryote a voir son genome entierement sequence grace a une collaboration scientifique a l'echelle internationale. Au sein du projet biotech, nous avons determine la sequence d'un fragment de 40 kb du chromosome xiv de la levure. L'analyse de ce fragment situe a proximite du telomere gauche a revele la presence de 24 orfs parmi lesquelles 8 correspondent a des genes connus, 8 autres orfs presentent soit des homologies significatives dans les banques de donnees, soit des motifs connus. Enfin les 8 orfs restantes sont consideree
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25

Gillet-Markowska, Alexandre. "Etude quantitative des variations structurelles des chromosomes chez Saccharomyces cerevisiae." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066233/document.

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L’accumulation de remaniements de la structure des chromosomes aussi appelés variations structurelles (SV) est un important contributeur à la transformation des cellules malignes et à la constitution d’une hétérogénéité intratumorale. Nous avons développé un outil bio-informatique qui permet désormais d’obtenir une image fine de ces SV qui se produisent dans le génome humain. Nous avons ainsi pu démontrer l’existence de SV présentes à de faibles fréquences dans différentes populations cellulaires supposées clonales montrant que les taux de formation des SV pourraient être grandement sous-estim
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26

Tsaponina, Olga. "Regulation of ribonucleotide reductase and the role of dNTP pools in genomic stability in yeast Saccharomyces cerevisiae." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43978.

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Every living organism is programmed to reproduce and to pass genetic information to descendants. The information has to be carefully copied and accurately transferred to the next generation.  Therefore organisms have developed the network of conserved mechanisms to survey the protection and precise transfer of the genetic information. Such mechanisms are called checkpoints and they monitor the correct execution of different cell programs. The DNA damage and the replication blocks are surveyed by the conserved Mec1-Rad53 (human ATM/ATR and Chk2, respectively) protein kinase cascade. Mec1 and Ra
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Martos, Alexandre. "Relocalisation expérimentale de gènes mitochondriaux au noyau : un éclairage nouveau sur l'évolution du génome mitochondrial." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22003/document.

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Malgré la relocalisation au noyau d'une majorité des gènes du procaryote ancestral à l'origine des mitochondries, une poignée de gènes réside encore dans l'organite après près de deux milliards d'années d'évolution. Les raisons du maintien d'un génome mitochondrial sont mal comprises. Je me suis intéressé à cette problématique via des expériences de relocalisation artificielle de gènes mitochondriaux chez la levure Saccharomyces cerevisiae. Nous avons réussi, pour la première, à exprimer de manière fonctionnelle depuis le noyau le gène ATP9 qui encode une petite protéine hydrophobe essentielle
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Tran, Grant. "Modeling drug efficacy in the tumour microenvironment with Saccharomyces cerevisiae genome-wide screens in hypoxic conditions." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60210.

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Hypoxia, the state of reduced oxygen, is a microenvironment found in many solid tumours and is correlated with an increased risk in patient mortality. This is due to an increase in resistance to radiotherapy and chemotherapy as well as a decrease in drug efficacy. The mechanisms and cellular factors (gene products) associated with this reduced chemotherapeutic efficacy in hypoxia remains unclear. This research looks to identify cellular processes and pathways that cancerous cells are able to exploit in order to survive and thrive in this microenvironment. The eukaryotic model baker’s yeast Sac
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Schlecht, Hélène. "Investigating the correlation between genome location, ectopic recombination and chromosome organisation during meiosis in Saccharomyces cerevisiae." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398663.

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Harbison, Christopher T. 1973. "Genome-wide analysis of transcriptional expression programs, regulatory networks and Cis-regulatory sequences in Saccharomyces cerevisiae." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/28933.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2005.<br>Includes bibliographical references.<br>Historically, knowledge of gene-specific transcription has been accumulated by the study of the individual genetic and physical interactions between transcriptional regulators and the genes they regulate, often requiring considerable time and effort. Microarray technology now enables investigation of gene expression at the level of the entire genome, allowing researchers access to rich datasets and promising new levels of depth in the understanding of transcriptional regul
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Jones, Hope. "Genetic Characterization and Analysis of Cis and Trans-elements That Facilitate Genome Stability in Saccharomyces cerevisiae." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/193584.

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Chromosomal fragile sites are specific loci associated with a high frequency of breakage and recombination. A cell's ability to repair and/or replicate through a lesion is prerequisite to the maintenance of genomic stability. An improved understanding of fragile site biology and its contribution to replication defects and genomic instability is critical for prevention, intervention, and diagnosis of genetic diseases such as cancer. This work seeks to identify and characterize both trans and cis fragile sites associated elements involved in instability onset and progression. An array of Sacc
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32

Biteau, Nicolas. "Faisabilité du séquençage systématique d'un chromosome : stratégies et exploration du génome de Saccharomyces cerevisiae." Bordeaux 2, 1993. http://www.theses.fr/1993BOR28241.

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Coi, Anna Lisa. "A genome based approach to characterize genes involved in yeast adaptation to Sherry-like wines’ biological ageing." Thesis, Montpellier, SupAgro, 2014. http://www.theses.fr/2014NSAM0005/document.

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La fermentation œnologique et le vieillissement oxydatif des vins sous voile représentent des modes de vie très contrastés qui sont effectués par deux lignées différentes de souches de levures de l'espèce Saccharomyces cerevisiae. Dans cette thèse, nous avons comparé le génome de souches de levures de voile à celui de levures de vin afin de détecter leurs spécificités. Nous tout d'abord sélectionné 16 souches (8 levures de vin et 8 levures de voile) isolées en France, Hongrie, Italie et Espagne, pour séquencer leur génome sur une plateforme Illumina (HiSeq2000). Nous avons également développé
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Mischo, Hannah. "Disengaging Polymerases : Transcriptional termination by RNA polymerase II in Saccharomyces cerevisiae and the maintenance of genome integrity." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514968.

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Colby, E. R. "Creating site-specific abasic sites in the genome of Saccharomyces cerevisiae to analyse replication-associated lesion bypass." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419675/.

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Abasic sites are thought to be one of the most frequently formed lesions within cells. They are particularly dangerous during DNA replication as they can block the progression of replication forks. Such stalled forks have the potential to collapse, which can impact genome stability and therefore cell survival. To complete replication in the presence of abasic sites, cells use DNA damage tolerance pathways that can bypass abasic sites without their repair. The in vivo study of DNA damage tolerance is complicated by the temporal and spatial nature of naturally occurring damage. To understand the
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Wu, Jingyan. "A Genome-wide Analysis to Identify and Characterize Novel Genes Involved in tRNA Biology in Saccharomyces cerevisiae." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429197786.

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Tuck, Alex Charles. "Genome-wide identification of non-canonical targets of messenger RNA synthesis and turnover factors in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11719.

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Pervasive transcription is widespread amongst eukaryotic genomes, and produces long noncoding RNAs (lncRNAs) in addition to classically annotated transcripts such as messenger RNAs (mRNAs). LncRNAs are heterogeneous in length and map to intergenic regions or overlap with annotated genes. Analogous to mRNAs, lncRNAs are transcribed by RNA polymerase II, regulated by common transcription factors, and possess 5’ caps and perhaps 3’ poly(A) tails. However, lncRNAs perform distinct functions, acting as scaffolds for ribonucleoprotein complexes or directing proteins to nucleic acid targets. The act
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38

Treu, Laura. "A genomic and transcriptomic approach to characterize oenological Saccharomyces cerevisiae strains." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422965.

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Genus Saccharomyces includes a large number of microorganisms that are important for industrial applications such as the production of fermented beverages, biofuel and baking. Natural selection combined with domestication applied selective pressures to the genome of this yeast producing large numbers of different strains with specialized phenotypes. During the last decades thousand of strains have been phenotypically characterized but correlation between phenotype and genotype is not yet completely unveiled. Genome sequence analysis is a crucial step to obtain a general description of gene co
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39

Peter, Jackson. "Dissection de la relation génotype-phénotype par des études d'association chez Saccharomyces cerevisiae." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ064/document.

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Un objectif central en biologie est de comprendre la relation entre le génotype et le phénotype. Afin de disséquer les bases génétiques de la diversité phénotypique, il est nécessaire de disposer d’une collection de données génomiques d’un grand nombre d’individus d’une même espèce. Dans ce but, mes travaux de thèse se basent sur l’étude des séquences génomiques ainsi que des données phénotypiques de 1011 isolats naturels de la levure Saccharomyces cerevisiae. Dans un premier temps, je me suis intéressé à la description de la variation génétique et phénotypique pour dresser un portrait précis
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40

TIAN, GUO-LIANG. "Recherches sur la structure et l'organisation du genome mitochondrial de la levure saccharomyces douglasii et d'un genome mitochondrial chimerique s. Douglasii et s. Cerevisiae." Paris 6, 1993. http://www.theses.fr/1993PA066260.

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Nous avons etabli la carte physique et genetique du genome mitochondrial de la levure saccharomyces douglasii. La capacite codante de ce genome est tres semblable a celle du genome mitochondrial de s. Cerevisiae. Les sequences nucleotidiques des genes coxi, aap1, oli2 et cytb ont ete etablies. La structure des genes morceles (coxi et cytb) est differente par rapport a ceux correspondants chez s. Cerevisiae (notamment la presence des nouveaux introns). La comparaison structurale des genomes mitochondriaux de s. Douglasii et s. Cerevisiae a revele la translocation d'un segment genomique d'enviro
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41

Schulze, Julia Maria. "Genome-wide analysis of chromatin modification patterns and their functional associations with major cellular processes in Saccharomyces cerevisiae." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29154.

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Chromatin is a nucleoprotein complex packaging DNA inside the cell nucleus and is of crucial relevance for genome regulation. Its structure is highly dynamic undergoing post-translational modifications, replacement by histone variants, and ATP-dependent remodelling. My dissertation aims to better understand the regulation of chromatin by studying the structure and function of a chromatin modifier, mapping chromatin modifications at a genome-wide scale, and linking modification patterns to cellular functions in the model organism Saccharomyces cerevisiae. Multiple chromatin modifying and transc
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Chu, Hui-Yi. "Genome-wide Investigation of Cellular Functions for tRNA Nucleus-Cytoplasm Trafficking in the Yeast Saccharomyces cerevisiae." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343397048.

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Jain, Shveta. "Genome-wide analysis of kinases and phosphatases reveal an essential MAP kinase involved in pexophagy in Saccharomyces cerevisiae." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1453663.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed July 28, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references.
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Dauban, Lise. "Organisation du génome par le complexe cohésine chez la levure Saccharomyces cerevisiae." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30100.

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La cohésine est un complexe protéique conservé dans l'évolution composé d'un anneau capable d'embrasser l'ADN et de protéines auxiliaires régulant son association avec l'ADN. D'une part, la cohésine confère la cohésion des chromatides sœurs nécessaire à leur ségrégation, d'autre part elle établit et maintient des boucles de chromatine. Ces boucles sont requises pour la formation de domaines topologiques, l'expression génique et la stabilité du génome. Cependant les mécanismes régissant leur formation ne sont pas entièrement élucidés. Selon le modèle d'extrusion de boucles, la cohésine capturer
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Lee, Ming-Ta. "Analysis of genome stability in mutants defective for the SUMO isopeptidase Smt4/Ulp2 /." Diss., UC access only, 2009. http://proquest.umi.com/pqdweb?index=6&did=1907279801&SrchMode=2&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1270053784&clientId=48051.

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Thesis (Ph. D.)--University of California, Riverside, 2009.<br>Includes abstract. Includes bibliographical references (leaves 213-243). Issued in print and online. Available via ProQuest Digital Dissertations.
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Humphryes, Neil. "Global genome nucleotide excision repair factors and the ubiquitin-proteasome system regulate the DNA damage response in Saccharomyces cerevisiae." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55468/.

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Delahodde, Agnès. "Activites arn-maturasique et adn-endonucleasique de deux proteines introniques homologues du genome mitochondrial de la levure saccharomyces cerevisiae." Paris 6, 1988. http://www.theses.fr/1988PA066185.

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Dans les mitochondries de levure saccharomyces cerevisiae, l'intron bi4 du gene codant pour le cytochrome b et l'intron ai4 du gene codant pour la sousunite i de la cytochrome oxydase possedent une phase de lecture ouverte qui peut-etre traduite en deux proteines homologues. Adaptation des codons uga, ava et cun de ces phases de lecture au code genetique universel de maniere a etudier leur fonction apres traduction dans le cytoplasme de levure ou dans escherichia coli. Chez la levure, les proteines traduites dans le cytoplasme penetrent dans la mitochondrie en associant le cote n terminal des
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Louvet, Olivier. "Analyse fonctionnelle de l'ORF YBR264c identifié lors du séquençage systématique du génome de la levure Saccharomyces Cerevisiae." Bordeaux 2, 1998. http://www.theses.fr/1998BOR28557.

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D'Angiolo, Melania Jennifer. "Étude des mécanismes moléculaires de l'évolution du génome chez la levure bourgeonnante Saccharomyces cerevisiae." Electronic Thesis or Diss., Université Côte d'Azur, 2021. http://theses.univ-cotedazur.fr/2021COAZ6001.

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L'évolution du génome consiste en la modification progressive de ce dernier au fil du temps et résulte de la variation des gènes dans leur ensemble, des mutations, des recombinaisons et échanges génétiques entre populations. L'essor des technologies de séquençage de nouvelle génération ainsi que la réduction de leur coût ont permis d’augmenter le nombre de génomes disponibles, permettant d’élucider les mécanismes moléculaires impliqués dans leur évolution. Dans ce travail, j'ai utilisé la levure bourgeonnante Saccharomyces cerevisiae pour étudier deux aspects fondamentaux de l'évolution du gén
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Mendez, Jamie Elizabeth. "Investigation of Hsf1 Interacting Partners via a Genome-wide Yeast Two-hybrid Screen." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4543.

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Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR), an evolutionarily conserved cellular stress response. HSF1 promotes the expression of a variety of molecular chaperones that aid in restoring protein homeostasis upon exposure to proteoxic stress. However, all of the proteins responsible for regulating the HSR together with HSF1 are unknown. A genome-wide yeast two hybrid screen was performed to identify new S. cerevisiae Hsf1 protein interacting partners. Two GAL4 DNA binding domain-Hsf1 fusion proteins (baits) were constructed with mutations
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