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Rozprawy doktorskie na temat „Scaffold Bone Defect”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Lui, Yuk-fai, and 呂旭輝. "Evaluation of porous polyurethane scaffold on facilitating healing in critical sized bone defect." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49858865.

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Bone graft substitute is a continuously developing field in orthopedics. When compared to tradition biomaterial in the field such as PLA or PCL, elastomer like polyurethane offers advantages in its high elasticity and flexibility, which establish an intimate contact with surrounding bones. This tight contact can provide a stable bone-material interface for cell proliferation and ingrowth of bone. The aim of this study is to evaluate the osteogenesis capabilities of a porous polyurethane scaffold in a critical size bone defect. In this study, a porous scaffold synthesized from segmented polyur

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Wojtowicz, Abigail M. "Genetically-engineered bone marrow stromal cells and collagen mimetic scaffold modification for healing critically-sized bone defects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34705.

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Non-healing bone defects have a significant socioeconomic impact in the U.S. with approximately 600,000 bone grafting procedures performed annually. Autografts and allografts are clinically the most common treatments; however, autologous donor bone is in limited supply, and allografts often have poor mechanical properties. Therefore, tissue engineering and regenerative medicine strategies are being developed to address issues with clinical bone grafting. The overall objective of this work was to develop bone tissue engineering strategies that enhance healing of orthotopic defects by targeti

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Hart, Amanda Peter. "BONE ENGINEERING OF THE ULNA OF RABBIT." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_theses/199.

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Repair of bone defects is a major challenge in orthopaedic surgery. Current bone graft treatments, including autografts, allografts and xenografts, have many limitations making it necessary to develop a biomaterial to be a bone graft substitute. One such biomaterial is bioactive resorbable silica-calcium phosphate nanocomposite (SCPC). SCPC was processed using a 3D rapid prototyping technique and sintered at different temperatures to create porous scaffolds. SEM analyses and mercury intrusion porosimetry showed SCPC to be highly porous with micro- and nanopores. BET analysis indicated that SCP

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Blomberger, Daniela. "Development of a novel Voronoi structured scaffold for critical-size bone defects." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/206168/1/Daniela_Blomberger_Thesis.pdf.

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Over the last decade, technological development has led to a revolution in the treatment of bone injuries. Few technologies hold more promise than 3D printing of biological material, which includes the field of bone science. This dissertation focused on 3D printed biodegradable scaffolds by using a novel Voronoy structured scaffold for critical-size bone defects that follows the definitions defined by mathematician Georgy Voronoy. These offer innovative healing opportunities for patients experiencing large bone defects, induced either by accidental or pathological causes, to regenerate the dam

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Reichert, Johannes Christian. "Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/48080/1/Johannes_Reichert_Thesis.pdf.

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Currently, well established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, their application, however, is associated with disadvantages. These include limited access and availability, donor site morbidity and haemorrhage, increased risk of infection, and insufficient transplant integration. As a result, recent research focuses on the development of complementar

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Henkel, Jan. "Bone tissue engineering in two preclinical ovine animal models." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/109909/1/Jan_Henkel_Thesis.pdf.

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This PhD-research was focused on the development and evaluation of innovative scaffold-based bone tissue engineering concepts for the treatment of large volume bone defects, which still represent a major challenge in orthopaedic and reconstructive surgery. Two different types of bone tissue engineering constructs were investigated and successfully applied to regenerate critically-sized segmental bone defects in ovine animal models. The results outlined in the PhD thesis represent a significant contribution to potential future clinical translations of bone tissue engineering concepts from bench

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Heidarkhan, Tehrani Ashkan. "Exploring methods of preparing functional cartilage-bone xenografts for joint repair." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/90556/1/Ashkan_Heidarkhan%20Tehrani_Thesis.pdf.

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This thesis explores the feasibility of donor-receiver concept for joint replacement where cartilage-bone tissues can be taken from either human or other mammals and prepared scientifically for repairing focal joint defects in knees, hips and shoulders. The manufactured construct is immunologically inert and is capable of acting as a scaffold for engineering new cartilage-bone laminates when placed in the joint. Innovative manufacturing procedures and assessment techniques were developed for appraising this tissue-based scaffold. This research has demonstrated that tissue replacement technolog

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Tim, Carla Roberta. "Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato® no processo de reparação óssea." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/6973.

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Made available in DSpace on 2016-08-17T18:39:36Z (GMT). No. of bitstreams: 1 3621.pdf: 12488772 bytes, checksum: 3b893af6e3b0ea869fd5eda12f270c8a (MD5) Previous issue date: 2011-02-24<br>Financiadora de Estudos e Projetos<br>Several resources have been studied in order to accelerate the process of bone repair. Among these resources, bioactive materials and low level laser therapy (LLLT) have gained prominence. Several studies suggest that both resources are able of stimulating osteoblast proliferation and osteogenesis at the fracture site, promoting a greater deposition of bone mass, which i

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Jones, Brendan John. "Reconstruction of critical-sized ovine mandibular defects - a pilot study." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/72238/1/Brendan_Jones_Thesis.pdf.

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Establishing the sheep model for translational research of mandible (jaw) segmental defect regeneration. Providing a framework from which additional experimentation and evaluation of novel tissue engineered constructs may be undertaken, compared and collated. For current and future novel approaches to mandible segmental defect reconstruction that may be transferable to the human condition and, ultimately, the operative table.

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Rentsch, Claudia, Wolfgang Schneiders, Ricarda Hess, et al. "Healing properties of surface-coated polycaprolactone-co-lactide scaffolds: A pilot study in sheep." Sage, 2014. https://tud.qucosa.de/id/qucosa%3A35693.

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The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds were implanted into a 3 cm sheep tibia critical size defect for 3 or 12 months (n¼5 each). Bone healing was estimated by quantification of bone volume in the defects on computer tomography and microcomputer tomography scans, plain radiographs, biomechanical testing as well as by his

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Hulsart, Billström Gry. "Bone Regeneration with Cell-free Injectable Scaffolds." Doctoral thesis, Uppsala universitet, Ortopedi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234846.

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Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to injury or diseases can be a great challenge and affect the patient significantly. Transplanting bone graft from one site in the patient to the site of fracture or bone void, i.e. autologous bone grafting is commonly used throughout the world. The transplanted bone not only fills voids, but is also bone inductive, housing the particular cells that are needed for bone regeneration. Nevertheless, a regenerative complement to autograft is of great int

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Hulsart, Billström Gry. "Bone Regeneration with Cell-free Injectable Scaffolds." Doctoral thesis, Uppsala universitet, Ortopedi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310312.

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Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to injury or diseases can be a great challenge and affect the patient significantly. Autologous bone grafting is commonly used throughout the world. Autograft both fills the void and is bone inductive, housing the particular cells that are needed for bone regeneration. However, a regenerative complement to autograft is of great interest as the use of biomaterials loaded with bioactive molecules can avoid donor site morbidity and the problem of a limi

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Liu, Gang. "Controlled Release of Growth Factors from Microsphere Scaffolds for Osteogenesis." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367685.

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Large bone defects present a major challenge to orthopaedic surgeons. Tissue engineering technology may provide a potential strategy to repair such defects, which involves the implantation of scaffold constructs typically loaded with cells and growth factors. It is expected that such growth factors loaded scaffolds can produce optimal microenvironments for the differentiation of seeded cells. The purpose of this project was to construct a dual growth factor release system in vitro using gelatin hydrogel and microspheres (MSs) to carry and deliver two growth factors, which have different effect

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PIVA, PAOLO. "Tissue engineering in oro-maxillary bone regeneration." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/203399.

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To synthesize a polyurethane (PU) foam-like scaffold which could perform both as a resorbable membrane and as a cavity filling material in oro-maxillary bone defects. MATERIALS & METHODS: A PU foam was synthesized via a onepot reaction starting from a pre-polymerized isocyanate and a biocompatible polyester diol, using water as a foaming agent. Different foaming conditions were examined, with the aim of creating a dense/porous functional graded material. The obtained PU was characterized in terms of morphological and mechanical properties. Biocompatibility assessment was performed in

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15

Parikh, Anand. "LONG-TERM CRANIAL RECONSTRUCTIONS IN FULL THICKNESS DEFECTS USING CARBONATED CALCIUM PHOSPHATE CEMENT WITH TITANIUM MESH SCAFFOLD IN A SHEEP MODEL: BIOMECHANICAL ANALYSIS." Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1164993505.

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Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2006.<br>"December, 2006." Title from electronic thesis title page (viewed 06/27/2007) Co-Advisors, Glen O. Njus, Daniel B. Sheffer; Faculty Reader, Mary C. Verstraete; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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Collignon, Anne-Margaux. "Utilisation de cellules souches pulpaires combinées à une matrice de collagène pour la réparation osseuse cranio-faciale Strategies developed to induce, direct, and potentiate bone healing Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells Mouse Wnt1-CRE-RosaTomato dental pulp stem cells directly contribute to the calvarial bone regeneration process Early angiogenesis detected by PET imaging with 64Cu-NODAGA-RGD is predictive of bone critical defect repair." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB113.

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La région cranio-faciale est particulièrement vulnérable aux pertes de structures. Sa localisation et sa visibilité font qu'une atteinte entraîne des troubles, aussi bien physiques (alimentation, phonation...) que psychologiques (intégrité de la personne...). Les traitements actuels (régénération osseuse guidée, autogreffe osseuse ou allogreffe) sont particulièrement invasifs et présentent un taux d'échec élevé. Tout cela affecte fortement la qualité de vie du patient. De plus, le coût direct de ces traitements est important pour les systèmes de santé et le patient. Il existe donc un réel beso

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Chang, Guang-Wei, and 張光偉. "Study of novel malleable composite scaffold for bone defect repair." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/6f7n6d.

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博士<br>國立臺北科技大學<br>化學工程與生物科技系化學工程博士班<br>106<br>An osteoconductive scaffold can facilitate bone defect repair. Bone defects are serious complications that are most commonly caused by extensive trauma, tumors, infections, or congenital musculoskeletal disorders. If nonunion occurs, the implantation of biomaterials developed as a bone defect filler, which can promote bone regeneration, is essential. In order to evaluate biomaterials for potential development as bone substitutes for bone defect repair, it is essential to establish clinically relevant in vitro and in vivo testing models to investiga

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Kuzyk, Paul Robert Thomas. "Evaluation of a biodegradable scaffold for the treatment of a diaphyseal bone defect of the tibia." 2008. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=771981&T=F.

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"Mechanistic study of phytoestrogenic icaritin and Its osteopromotive effects after incorporation into a composite scaffold for enhancing bone defect repair in steroid associated osteonecrosis (SAON)." 2012. http://library.cuhk.edu.hk/record=b5549546.

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激素性骨壞死是由於經常使用脈衝性激素處理非骨科性問題引起的一種常見的骨科疾病。在組織病理學上，激素性骨壞死指骨死亡，血管內血栓閉塞和血管外骨髓脂肪沉積會引起缺血導致骨修復不足。上游的分子細胞病理學機制研究表明間充質幹細胞細胞池活性下降，成骨細胞凋亡和骨小梁基質退變導致的不充分修復是激素性骨壞死發生的重要因素。<br>間充質幹細胞是骨髓的基質組成部分，具有分化成多種細胞的潛能。最近的研究表明，激素性骨壞死可能是骨細胞和/或間質幹細胞病變引起的一種疾病。研究發現，在接受類固醇治療而發生骨壞死的病人中，骨髓間充質幹細胞活性下降和分化潛能發生改變。在骨髓細胞中，激素能夠誘導脂肪發生。盛輝等發現來源於激素性骨壞死兔子中的間充質幹細胞成脂分化增強，謝新薈等進一步發現發生激素性骨壞死的兔子，骨缺損修復延遲，這可能是由激素導致的間充質幹細胞潛能發生改變引起的。綜合以上研究表明，間充質幹細胞在骨壞死發生和修復過程中起著重要作用。我們之前報導過淫羊藿黃酮（EFs）的腸代謝產物淫羊藿素Icaritin通過抑制血栓的形成和脂肪沉澱預防激素性骨壞死。最近，我們把Icaritin整合到聚乳酸聚乙醇酸共聚物/磷酸三鈣（PLGA/TCP）支架材料中，形成PLGA/TCP/Icaritin複合支架材料。我們發現PLGA/TCP/Icaritin複合材料可以促進激素性骨壞死骨缺損的修復，肌肉移植發現PLGA/TCP/

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LO, GIUDICE ROBERTO. "L’uso degli scaffold nella rigenerazione dei difetti ossei: sviluppo dei sistemi di customizzazione nelle tecniche sottrattive." Doctoral thesis, 2019. http://hdl.handle.net/11570/3146798.

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La medicina rigenerativa è oggi uno tra i campi più interessante della biotecnologia, in grado di combinare diversi aspetti della medicina della biologia cellulare e molecolare dei biomateriali e dell'ingegneria dei tessuti, finalizzata a rigenerare, riparare o sostituire tessuti. La linea di ricerca proposta, sulla base di studi che analizzano vari aspetti della rigenerazione ossea in campo medico è rivolta al miglioramento delle tecniche già utilizzate in questo ambito e si propone di realizzare un sistema integrato standardizzato. Il substrato scelto per l'analisi è costituito da osso equin

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Che, Chen Po, and 陳柏哲. "PLGA-HAP-Silica Composite Scaffolds for Bone Defect Repair." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/96200897106558982812.

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碩士<br>南台科技大學<br>化學工程與材枓工程系<br>96<br>This study is to fabricate there dimensional porous scaffolds through freeze-drying method by completely mixing of either polylactic-co-glycolic acid (PLGA) or PLGA-OH, dioxane and water. It’s biocompatibility and mechanical properties could be enhanced by adding hydroxyapatite (HAP) and nano-SiO2. The different ratio of dioxane and water, dipping temperature, and the concentration of PLGA on the effect of morphology, porosity, pore size, and degradation test of scaffolds were investigated in this study. The SEM results showed that the pore size changed with

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"Bioactive PLGA/TCP composite scaffolds incorporating phytomolecule icaritin developed for bone defect repair." 2012. http://library.cuhk.edu.hk/record=b5549420.

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研究背景：常规骨科临床在治疗大段骨缺损时需要移植骨和（或）支架材料，尤其复合有治疗性生物活性成分的复合材料尤为理想。本研究的策略在于发展开发一种具有生物活性和生物降解特性的的合并有植物小分子icaritin（外源性生长因子）或者骨形态发生蛋白2（BMP-2, 内源性生长因子）的复合骨支架用于骨再生。基于聚乳酸乙交酯共聚物和磷酸三钙，我们利用先进的快速成型技术编制了新型的符合有BMP-2 或者icaritin 的支架材料，命名为PLGA/TCP （对照材料组），PLGA/TCP/BMP-2（BMP-2 编织复合治疗材料组）， PLGA/TCP/icaritin （低，中，高剂量icaritin 编织复合治疗材料组）。<br>研究目标：本研究的总体目标是通过系统的体外实验和兔骨缺损的体内实验，建立和评估一种优化的复合递送系统，用于骨再生的应用。体内效果的研究体现在终点关于合并有外源性生长因子icaritin 和内源性生长因子BMP-2 的复合材料之间的比较研究。<br>材料和方法：低温快速成型机器用于复合材料的编制。PLGA 和TCP 作为基本载体材料，icaritin 和BMP-2 作为具有生物活性的外源性和内源性生长因子，分别进行编织复合。最终编织复合的支架材料命名为P/T 对照组，P/T/BMP-2 和低，中，高剂量P/T/icaritin 治疗组。另外，我们通过液体完全浸

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Zhang, Dawei. "Inorganic-Organic Shape Memory Polymers and Foams for Bone Defect Repairs." Thesis, 2013. http://hdl.handle.net/1969.1/149404.

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The ultimate goal of this research was to develop a “self-fitting” shape memory polymer (SMP) scaffold for the repair of craniomaxillofacial (CMF) bone defects. CMF defects may be caused by trauma, tumor removal or congenital abnormalities and represent a major class of bone defects. Their repair with autografts is limited by availability, donor site morbidity and complex surgical procedures. In addition, shaping and positioning of these rigid grafts into irregular defects is difficult. Herein, we have developed SMP scaffolds which soften at T > ~56 °C, allowing them to conformally fit into a

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Amaral, Miguel Filipe Lourenço de. "Development of multifunctional hybrid scaffolds for massive bone defects filling and regeneration." Master's thesis, 2021. http://hdl.handle.net/10362/130561.

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Despite the growing number of survival cases, due to the increase in cases, the death rate from cancer-related diseases has been increasing over the years. Being less than 0.2% of all cancers, primary bone cancers are extremely unusual and often curable. However, about 50% of these tumors can metastasize, so early intervention is frequently necessary. Tumor or tumor-like resection derived from osteosarcoma usually leads to the creation of large bone defects, which constitute a reconstructive problem. The current standard procedures used to resolve this and other related issues are via

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Gardel, Leandro da Silva. "Autologous bone tissue engineering strategies envisioning the regeneration of critical size defects using cell-seeded scaffolds and a newly developed perfusion bioreactor." Doctoral thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/73874.

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Chen, Min-Chia, та 陳敏嘉. "Effect of Computer-designed 3D-Printed Poly ɛ-caprolactone Scaffolds and Plasma-rich fibrin on Bone Formation in Calvarial Defects in Rats". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/4k44kf.

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碩士<br>國防醫學院<br>牙醫科學研究所<br>106<br>Background: In guiding bone formation, creating an adequate space is critical due to defect complexity. In this study, a polycaprolactones (PCL) scaffold, computer designed and 3D-printed, was implanted into the critical-sized calvaria defect in rat, whereas the effect of plasma-rich fibrin (PRF) on the bone formation was also tested. Methods: Two round defects, 6 mm in diameter, were surgically created in parietal bones of 32 rats, then 4 defect groups, including defect control, PRF, PCL, and PCL-plus-PRF (PRF+PCL), were divided according to scaffold implant

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Gardel, Leandro da Silva. "Autologous bone tissue engineering strategies envisioning the regeneration of critical size defects using cell-seeded scaffolds and a newly developed perfusion bioreactor." Tese, 2013. https://repositorio-aberto.up.pt/handle/10216/73874.

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Rau, Anna. "Radiomorphometrische Untersuchung der Knochenregeneration in vivo durch kombinierte Freisetzung von VEGF und BMP aus den PDLLA/CaCO3-Komposit-Scaffolds." Doctoral thesis, 2021. http://hdl.handle.net/21.11130/00-1735-0000-0005-157B-A.

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Michalak, Milosch. "Therapie osteochondraler Defekte des Kniegelenks unter Verwendung des Knorpel-Knochen-Ersatzmaterials (TruFit®) in Kombination mit einer einzeitigen autologen Knorpelzelltransplantation im Langzeittierversuch." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-5FB0-A.

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Knorpeldefekte des Kniegelenks zeichnen sich durch eine sehr begrenzte spontane Heilungstendenz aus und führen im Verlauf häufig zur Arthrose. Trotz intensiver Forschungsbemühungen konnte bisher keine neue Therapieoption eine zufrieden-stellende Alternative zu den bisherigen Therapien hervorbringen. Eine ACI in Kombination mit einem künstlich hergestellten Knorpel-Knochen-Ersatzmaterial scheint jedoch großes Potential für die Therapie von Knorpel-Knochen-Schäden zu besitzen. Im vorliegenden Langzeittierversuch mit Kaninchen wurde eine einzeitige ACI mit einem biphasischen Ersatzmaterial (TruF

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