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Artykuły w czasopismach na temat „Sensory receptors”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Yu, Jerry. "Deflation-activated receptors, not classical inflation-activated receptors, mediate the Hering-Breuer deflation reflex." Journal of Applied Physiology 121, no. 5 (2016): 1041–46. http://dx.doi.org/10.1152/japplphysiol.00903.2015.

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Many airway sensory units respond to both lung inflation and deflation. Whether those responses to opposite stimuli come from one sensor (one-sensor theory) or more than one sensor (multiple-sensor theory) is debatable. One-sensor theory is commonly presumed in the literature. This article proposes a multiple-sensor theory in which a sensory unit contains different sensors for sensing different forces. Two major types of mechanical sensors operate in the lung: inflation- and deflation-activated receptors (DARs). Inflation-activated sensors can be further divided into slowly adapting receptors

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2

Montell, Craig. "Drosophila sensory receptors—a set of molecular Swiss Army Knives." Genetics 217, no. 1 (2021): 1–34. http://dx.doi.org/10.1093/genetics/iyaa011.

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Abstract Genetic approaches in the fruit fly, Drosophila melanogaster, have led to a major triumph in the field of sensory biology—the discovery of multiple large families of sensory receptors and channels. Some of these families, such as transient receptor potential channels, are conserved from animals ranging from worms to humans, while others, such as “gustatory receptors,” “olfactory receptors,” and “ionotropic receptors,” are restricted to invertebrates. Prior to the identification of sensory receptors in flies, it was widely assumed that these proteins function in just one modality such

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3

Yu, Jerry. "Spectrum of myelinated pulmonary afferents (III) cracking intermediate adapting receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 319, no. 6 (2020): R724—R732. http://dx.doi.org/10.1152/ajpregu.00136.2020.

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Conventional one-sensor theory (one afferent fiber connects to a single sensor) categorizes the bronchopulmonary mechanosensors into the rapidly adapting receptors (RARs), slowly adapting receptors (SARs), or intermediate adapting receptors (IARs). RARs and SARs are known to sense the rate and magnitude of mechanical change, respectively; however, there is no agreement on what IARs sense. Some investigators believe that the three types of sensors are actually one group with similar but different properties and IARs operate within that group. Other investigators (majority) believe IARs overlap

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4

Birder, Lori A., and Edward R. Perl. "Cutaneous Sensory Receptors." Journal of Clinical Neurophysiology 11, no. 6 (1994): 534–52. http://dx.doi.org/10.1097/00004691-199411000-00002.

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Burnside, Beth. "Cytoskeletal functions in sensory receptors." Proceedings, annual meeting, Electron Microscopy Society of America 47 (August 6, 1989): 796–97. http://dx.doi.org/10.1017/s0424820100155955.

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Since the shapes of sensory receptors are so exquisitely specialized for mediating their unique functions, the cytoskeletons of sensory cells are deployed for morphogenetic and motile objectives in particularly interesting ways. Receptors erect cytoskeletal scaffolding to support two basic sorts of surface elaborations: 1) those designed to achieve the most effective presentation of specialized membrane laden with receptor proteins (photoreceptors, olfactory receptors, taste cells, and chemoreceptors), and 2) those designed to respond directly to mechanical perturbations in the cell's environm

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6

Adetunla, Adedotun O., Olanrewaju Kolade, Adeyinka M. Adeoye, and Saheed Akande. "Development of a Prototype Sensory Device as a Substitute for Single Sided Deaf People in Developing Nations." Journal Européen des Systèmes Automatisés 55, no. 6 (2022): 765–69. http://dx.doi.org/10.18280/jesa.550608.

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Hearing loss is the inability to hear sounds ranging from 20 decibels or more in one or both ears. It can affect one or both ears and leads to difficulty in hearing speech or sounds in general. Single-sided deafness or unilateral hearing loss is a very widespread disability. However, most people only see hearing loss as being a binary problem assuming that you either have perfect hearing in both ears or are completely deaf in both ears, and dismiss the other types of hearing loss. Sensory substitution involves remapping the information gathered by one sensory receptor to another. Sensory recep

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7

Jablońska, Beata, and Jolanta Skangiel-Kramska. "Sensory conditioning and sensory stimulation do not affect GABAA receptor binding in the barrel field of mice." Acta Neurobiologiae Experimentalis 55, no. 4 (1995): 289–93. http://dx.doi.org/10.55782/ane-1995-1088.

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The whisker-to-barrel system of adult mice was used in a study on the effects of short-lasting tactile stimulation and sensory conditioning training on GABAA receptor binding in the barrel field of somatosensory cortex. In vitro receptor binding autoradiography was used to examine the pattern and intensity of [3H]muscimol binding to GABAA receptors. A well-defined pattern of GABAA receptors in the barrel field remained unaffected after both procedures used. Also, no differences in intensity of GABAA receptor binding were observed. These results suggest that GABAA receptors are not involved in

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8

Julius, D., and J. Nathans. "Signaling by Sensory Receptors." Cold Spring Harbor Perspectives in Biology 4, no. 1 (2011): a005991. http://dx.doi.org/10.1101/cshperspect.a005991.

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9

Proske, U., J. E. Gregory, and A. Iggo. "Sensory receptors in monotremes." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 353, no. 1372 (1998): 1187–98. http://dx.doi.org/10.1098/rstb.1998.0275.

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This is a summary of the current knowledge of sensory receptors in skin of the bill of the platypus, Ornithorhynchus anatinus , and the snout of the echidna, Tachyglossus aculeatus . Brief mention is also made of the third living member of the monotremes, the long–nosed echidna, Zaglossus bruijnii . The monotremes are the only group of mammals known to have evolved electroreception. The structures in the skin responsible for the electric sense have been identified as sensory mucous glands with an expanded epidermal portion that is innervated by large–diameter nerve fibres. Afferent recordings

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10

DeMaria, Shannon, and John Ngai. "The cell biology of smell." Journal of Cell Biology 191, no. 3 (2010): 443–52. http://dx.doi.org/10.1083/jcb.201008163.

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The olfactory system detects and discriminates myriad chemical structures across a wide range of concentrations. To meet this task, the system utilizes a large family of G protein–coupled receptors—the odorant receptors—which are the chemical sensors underlying the perception of smell. Interestingly, the odorant receptors are also involved in a number of developmental decisions, including the regulation of their own expression and the patterning of the olfactory sensory neurons' synaptic connections in the brain. This review will focus on the diverse roles of the odorant receptor in the functi

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11

Koo, Ho, Jigong Wang, Ramesh Pariyar, Regan M. Hammond, and Jun-Ho La. "Modulation of mechanosensation by endogenous dopaminergic signaling in the lateral parabrachial nucleus in mice." PAIN Reports 9, no. 5 (2024): e1186. http://dx.doi.org/10.1097/pr9.0000000000001186.

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Abstract Introduction: The lateral parabrachial nucleus (LPBN), a crucial hub for integrating and modulating diverse sensory information, is known to express both D1 and D2 dopamine receptors and receive dopaminergic inputs. However, the role of the LPBN's dopaminergic system in somatosensory processing remains largely unexplored. In this study, we investigated whether mechanical sensory stimulation triggers dopamine release in the LPBN and how D1- and D2-like receptor signaling in the LPBN influences mechanosensitivity in mice. Methods: We used a G-protein-coupled receptor–based dopamine sens

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12

Wang, Hui, Donna H. Wang, and James J. Galligan. "P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298, no. 6 (2010): R1634—R1641. http://dx.doi.org/10.1152/ajpregu.00235.2009.

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The transient receptor potential vanilloid type 1 (TRPV1) channel is a ligand-gated cation channel expressed by sensory nerves. P2Y receptors are G protein-coupled receptors that are also expressed by TRPV1-positive sensory neurons. Therefore, we studied interactions between P2Y receptors and TRPV1 function on kidney projecting sensory neurons. Application of Fast Blue (FB) to nerves surrounding the renal artery retrogradely labeled neurons in dorsal root ganglia of rats. Whole cell recording was performed on FB-labeled neurons maintained in primary culture. Capsaicin was used to activate TRPV

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13

Hocker, Geoffrey A. "A Hypothesis to Explain how the Sensory Cortices Respond in the Appropriate Sensory Mode." Journal of the Royal Society of Medicine 96, no. 2 (2003): 70–73. http://dx.doi.org/10.1177/014107680309600205.

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How does an area of sensory cortex recognize the specific nature of the sensory mode of the stimulus that arrives from the peripheral sensory receptor, when nerve impulses are only all-or-nothing action potentials? Work in animals has shown that an area of sensory cortex can learn in which mode to respond. A period of cortical learning is required for phantom limb phenomena to develop, and for the ocular blind to dream in the visual mode. Arguing from these facts I develop the hypothesis that within the sensory cortices there are neurons that learn by neurotropic factor transport from their se

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14

Bowker, R. M., A. M. Brewer, K. B. Vex, et al. "Sensory receptors in the equine foot." American Journal of Veterinary Research 54, no. 11 (1993): 1840–44. http://dx.doi.org/10.2460/ajvr.1993.54.11.1840.

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Summary Two types of sensory receptors were located in the equine foot, using anatomic techniques. Histologic examination of stained hoof sections revealed lamellated corpuscles in the hoof dermis, which had many of the morphologic characteristics of Pacinian corpuscles. These sensory receptors were restricted to the palmar (caudal) aspects of the solar dermis of the heel. A second type of receptor was detected by use of immunocytochemistry, indicating apparently naked nerve endings containing the neuropeptide calcitonin gene-related peptide-like immunoreactivity in skin, solar dermal tubules,

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15

Rohde, K., and NA Watson. "Ultrastructure of Sensory Receptors of an Undescribed Species of Luridae (Platyhelminthes, Rhabdocoela)." Australian Journal of Zoology 41, no. 1 (1993): 53. http://dx.doi.org/10.1071/zo9930053.

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Nine types of uniciliate sensory receptors are described from an undescribed species of Luridae: a collar receptor with a collar formed by 7-8 rods; a receptor with a long vertical and short horizontal rootlet and a thick ring-like electron-dense collar; a receptor with an approximately 2-mum-long cilium that has a narrow bent tip; a bulbous receptor with a short bulbous cilium; an intraepidermal receptor with a short cilium enclosed in an epidermal cavity; a receptor with a long cilium, short ciliary rootlet and electron-dense rod; pharyngeal receptors with long (at least 4 mum long) and shor

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16

Norton, Charles E., Elizabeth A. Grunz-Borgmann, Marcia L. Hart, Benjamin W. Jones, Craig L. Franklin, and Erika M. Boerman. "Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease." American Journal of Physiology-Heart and Circulatory Physiology 320, no. 5 (2021): H1887—H1902. http://dx.doi.org/10.1152/ajpheart.00037.2021.

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Our study is the first to show that IBD causes profound impairment of sensory vasodilation and inhibition of sympathetic vasoconstriction in mesenteric arteries. This occurs alongside decreased SP-containing nerve density and increased expression of NK1 receptors for SP. In contrast, CGRP dilation, nerve density, and receptor expression are unchanged. Blocking NK1 receptors restores sensory vasodilation in MAs and increases CGRP-mediated vasodilation, indicating that SP interference with CGRP signaling may underlie impaired sensory vasodilation with IBD.

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17

Vlajkovic, Srdjan M., and Peter R. Thorne. "Purinergic Signalling in the Cochlea." International Journal of Molecular Sciences 23, no. 23 (2022): 14874. http://dx.doi.org/10.3390/ijms232314874.

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The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues. Two families of P2 receptors, ATP-gated ion channels (P2X receptors) and G protein-coupled P2Y receptors, activate intracellular signalling pathways that regulate cochlear development, homeostasis, sensory transduction, auditory neurotransmission and response

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18

Cervero, Fernando. "Ainsley Iggo. 2 August 1924—25 March 2012." Biographical Memoirs of Fellows of the Royal Society 67 (August 14, 2019): 217–36. http://dx.doi.org/10.1098/rsbm.2019.0023.

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Ainsley Iggo's research was focused on the functional properties of sensory receptors in the skin and viscera. He developed a new electrophysiological technique for recording the electrical activity of individual afferent fibres and was the first to record such activity from single unmyelinated afferents, the smallest diameter afferents in sensory nerves. His seminal work contributed to the discovery of nociceptors; the sensory receptors that respond to injury and are at the origin of pain sensation. He also recorded the functional activity of many types of sensory receptor in the skin, muscle

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19

MORAN, DAVID T. "Evolutionary Patterns in Sensory Receptors." Annals of the New York Academy of Sciences 510, no. 1 Olfaction and (1987): 1–8. http://dx.doi.org/10.1111/j.1749-6632.1987.tb43458.x.

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Bradley, Robert M. "Sensory receptors of the larynx." American Journal of Medicine 108, no. 4 (2000): 47–50. http://dx.doi.org/10.1016/s0002-9343(99)00339-3.

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Wade, Nicholas J. "Microscopic anatomy of sensory receptors." Journal of the History of the Neurosciences 28, no. 3 (2019): 285–306. http://dx.doi.org/10.1080/0964704x.2018.1554298.

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Burnstock, G. "P2X receptors in sensory neurones." British Journal of Anaesthesia 84, no. 4 (2000): 476–88. http://dx.doi.org/10.1093/oxfordjournals.bja.a013473.

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23

Li, Huafeng, Lei Du, Peyman Otmishi, Yuwen He, Juan Guardiola, and Jerry Yu. "Opposite responses to lidocaine between intrapulmonary mechanical and chemical sensors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297, no. 3 (2009): R853—R858. http://dx.doi.org/10.1152/ajpregu.00013.2009.

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We attempted to determine whether intrapulmonary sensory receptors are nourished by the pulmonary or the systemic circulation. Single-unit activity from the cervical vagus nerve was recorded in anesthetized, open chest, mechanically ventilated rabbits, comparing responses to right or left ventricular injection of 2% lidocaine (at 4 mg/kg). Airway mechanosenors [slowly adapting receptor (SARs) and rapidly adapting receptors] were inhibited by lidocaine, whereas chemosensors (C-fiber receptors and high-threshold Aδ-receptors) were stimulated. Furthermore, all types of airway sensors were perfuse

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24

Panek, Izabela, Shannon Meisner, and Päivi H. Torkkeli. "Distribution and Function of GABAB Receptors in Spider Peripheral Mechanosensilla." Journal of Neurophysiology 90, no. 4 (2003): 2571–80. http://dx.doi.org/10.1152/jn.00321.2003.

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The mechanosensilla in spider exoskeleton are innervated by bipolar neurons with their cell bodies close to the cuticle and dendrites attached to it. Numerous efferent fibers synapse with peripheral parts of the mechanosensory neurons, with glial cells surrounding the neurons, and with each other. Most of these efferent fibers are immunoreactive to γ-aminobutyric acid (GABA), and the sensory neurons respond to agonists of ionotropic GABA receptors with a rapid and complete inhibition. In contrast, little is known about metabotropic GABAB receptors that may mediate long-term effects. We investi

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25

Lundberg, Jan M. "Tachykinins, sensory nerves, and asthma—an overview." Canadian Journal of Physiology and Pharmacology 73, no. 7 (1995): 908–14. http://dx.doi.org/10.1139/y95-125.

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Tachykinin peptides, substance P (SP) and neurokinin A (NKA), are released from airway sensory nerves upon exposure to irritant chemicals and endogenous agents including bradykinin, prostaglandins, histamine, and protons. The released neuropeptides are potent inducers of a cascade of responses, including vasodilatation, mucus secretion, plasma protein extravasation, leukocyte adhesion–activation, and bronchoconstriction. Neurokinin 1 receptors (preferably activated by SP) seem to be most important for inflammatory actions, while neurokinin 2 receptors (preferably activated by NKA) mediate bron

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Yoon, Hyun-Ji, and Sung-Cherl Jung. "Reactive oxygen species-specific characteristics of transient receptor potential ankyrin 1 receptor and its pain modulation." Journal of Medicine and Life Science 20, no. 1 (2023): 1–7. http://dx.doi.org/10.22730/jmls.2023.20.1.1.

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Transient receptor potential ankyrin 1 (TRPA1) receptors are major polymodal nociceptors that generate primary pain responses in the peripheral nerve endings of the dorsal root ganglion neurons. Recently, we reported that the activation of TRPA1 receptors by reactive oxygen species (ROS) signaling, which is triggered by Ca<sup>2+</sup> influx through T-type Ca<sup>2+</sup> channels, contributes to prolonged pain responses induced by jellyfish toxin. In this review, we focus on the characteristics of the TRPA1 receptor involved in intracellular signaling as a secondary p

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27

Connelly, Timothy, Agnes Savigner, and Minghong Ma. "Spontaneous and sensory-evoked activity in mouse olfactory sensory neurons with defined odorant receptors." Journal of Neurophysiology 110, no. 1 (2013): 55–62. http://dx.doi.org/10.1152/jn.00910.2012.

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Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in establishing proper synaptic connections and may also increase the sensitivity of the cells. However, where the spontaneous activity originates and whether it informs sensory-evoked activity remain unclear. We addressed these questions by examining patch-clamp recordings of genetically labeled mouse

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Rogers, Duncan F. "Neurokinin receptors subserving airways secretion." Canadian Journal of Physiology and Pharmacology 73, no. 7 (1995): 932–39. http://dx.doi.org/10.1139/y95-129.

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Mucus secretion can be induced in the airways by activation of nerves. The principal mechanism mediating neurogenic mucus secretion is cholinergic. However, a small but significant secretory response remains after adrenoceptor and cholinoceptor blockade. The identity of this nonadrenergic, noncholinergic (NANC) neural mechanism is unclear but includes an orthodromic pathway and a capsaicin-sensitive "sensory-efferent" (or "local effector") pathway. The orthodromic pathway comprises cholinergic nerves (and to a much lesser extent adrenergic nerves) in which neuropeptides, including vasoactive i

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Pan, Wen, Li-Na Cui, Chun-Ping Chu, Wen-Zhe Jin, and De-Lai Qiu. "Etomidate Modulates the Tactile Stimulation-Evoked Field Potential Responses in Cerebellar Granule Cell Layer in vivo in Mice." Pharmacology 104, no. 5-6 (2019): 287–95. http://dx.doi.org/10.1159/000502133.

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Etomidate (ET) produces sedation by binding on the γ-aminobutyric acid type A (GABAA) receptors. We previously found that ET inhibited cerebellar Purkinje cells activity via both GABAA and glycine receptors in vivo in mice, suggesting that ET modulated sensory information synaptic transmission in cerebellar cortex. In this study, we investigated the effect of ET on the sensory stimulation-evoked responses in the cerebellar granule layer (GL) in urethane-anesthetized mice, using electrophysiological and pharmacological methods. Our results showed that cerebellar surface perfusion of ET (100 μmo

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Huang, M. H., C. Sylven, M. Horackova, and J. A. Armour. "Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 269, no. 2 (1995): R318—R324. http://dx.doi.org/10.1152/ajpregu.1995.269.2.r318.

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Effects elicited by adenosine and substance P on ventricular sensory endings of 14 dorsal root ganglion afferent neurons were studied in situ in anesthetized dogs. Sensory-field application of adenosine (1 microM) increased the activity of these neurons by 179%. Application of a nonspecific adenosine antagonist to epicardial sensory fields suppressed ongoing activity in all 14 neurons by 39%. Application of an A1- or A2-adenosine-receptor antagonist suppressed activity generated by 10 of these neurons by 44 and 59%, respectively. Adenosine applied after A1- or A2-receptor blockade increased ac

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Dunn, Tyler W., Carole A. Farah, and Wayne S. Sossin. "Inhibitory responses in Aplysia pleural sensory neurons act to block excitability, transmitter release, and PKC Apl II activation." Journal of Neurophysiology 107, no. 1 (2012): 292–305. http://dx.doi.org/10.1152/jn.00767.2011.

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Expression of the 5-HT1Apl(a) receptor in Aplysia pleural sensory neurons inhibited 5-HT-mediated translocation of the novel PKC Apl II in sensory neurons and prevented PKC-dependent synaptic facilitation at sensory to motoneuron synapses ( Nagakura et al. 2010 ). We now demonstrate that the ability of inhibitory receptors to block PKC activation is a general feature of inhibitory receptors and is found after expression of the 5-HT1Apl(b) receptor and with activation of endogenous dopamine and FMRFamide receptors in sensory neurons. Pleural sensory neurons are heterogeneous for their inhibitor

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Mori, K. "Grouping of odorant receptors: odour maps in the mammalian olfactory bulb." Biochemical Society Transactions 31, no. 1 (2003): 134–36. http://dx.doi.org/10.1042/bst0310134.

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The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is converted into that at the cellular level (olfactory sensory neurons) by the one sensory neuron–one odorant receptor rule, and then into that at the neuronal circuit level in the olfactory bulb by the specific olfactory axon connectivity pattern. Individual glomeruli in the olfactory bu

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van Giesen, Lena, and Paul A. Garrity. "More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture." F1000Research 6 (September 26, 2017): 1753. http://dx.doi.org/10.12688/f1000research.12013.1.

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The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates. Recent work shows that, though initially studied as olfactory receptors, the IRs also mediate the detection of taste, temperature, and humidity. Here, we summarize recent insights into IR evolution and its potential ecological significance as well as recent advances in our understanding of how IRs contribute to diverse sensory modalities.

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Prado, Judith, Remco H. S. Westerink, Jelena Popov-Celeketic, et al. "Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways." Proceedings of the National Academy of Sciences 118, no. 11 (2021): e2009647118. http://dx.doi.org/10.1073/pnas.2009647118.

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New therapeutic approaches to resolve persistent pain are highly needed. We tested the hypothesis that manipulation of cytokine receptors on sensory neurons by clustering regulatory cytokine receptor pairs with a fusion protein of interleukin (IL)-4 and IL-10 (IL4–10 FP) would redirect signaling pathways to optimally boost pain-resolution pathways. We demonstrate that a population of mouse sensory neurons express both receptors for the regulatory cytokines IL-4 and IL-10. This population increases during persistent inflammatory pain. Triggering these receptors with IL4–10 FP has unheralded bio

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Shahbandi, Ashkan, Ezen Choo, and Robin Dando. "Receptor Regulation in Taste: Can Diet Influence How We Perceive Foods?" J 1, no. 1 (2018): 106–15. http://dx.doi.org/10.3390/j1010011.

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Taste buds are the dedicated sensory end organs of taste, comprising a complex and evolving profile of signaling elements. The sensation and ultimate perception of taste depends on the expression of a diverse array of receptors and channels that sense their respective tastes. Receptor regulation is a recognized and well-studied phenomenon in many systems, observed in opioid addiction, insulin resistance and caffeine tolerance. Results from human sensory studies suggest that receptor sensitivity or expression level may decrease after chronic exposure to respective tastants through diet. We revi

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Hu, Jinghua, Samuel G. Wittekind, and Maureen M. Barr. "STAM and Hrs Down-Regulate Ciliary TRP Receptors." Molecular Biology of the Cell 18, no. 9 (2007): 3277–89. http://dx.doi.org/10.1091/mbc.e07-03-0239.

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Cilia are endowed with membrane receptors, channels, and signaling components whose localization and function must be tightly controlled. In primary cilia of mammalian kidney epithelia and sensory cilia of Caenorhabditis elegans neurons, polycystin-1 (PC1) and transient receptor polycystin-2 channel (TRPP2 or PC2), function together as a mechanosensory receptor-channel complex. Despite the importance of the polycystins in sensory transduction, the mechanisms that regulate polycystin activity and localization, or ciliary membrane receptors in general, remain poorly understood. We demonstrate th

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Shimada, Kunio. "Morphological Configuration of Sensory Biomedical Receptors Based on Structures Integrated by Electric Circuits and Utilizing Magnetic-Responsive Hybrid Fluid (HF)." Sensors 22, no. 24 (2022): 9952. http://dx.doi.org/10.3390/s22249952.

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Biomedical receptors such as cutaneous receptors or intelligent cells with tactile, auditory, gustatory, and olfactory sensations function in the five senses of the human body. Investigations focusing on the configuration of such receptors are useful in the fields of robotics and sensors in the food industry, among others, which involve artificial organs or sensory machines. In the present study, we aimed to produce the receptors for four senses (excepting vision) by morphologically mimicking virtual human ones. The mimicked receptors were categorized into eight types of configured structure.

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Zhang, Peng, Qi Xu, and Ji Ping He. "Review and Perspective: Sensory Feedback in Upper Limb Prosthesis." Applied Mechanics and Materials 303-306 (February 2013): 261–65. http://dx.doi.org/10.4028/www.scientific.net/amm.303-306.261.

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An emerging challenge in developing intelligent prostheses is to replicate or recreate the sensory functions of natural limbs for amputees. Such functions mainly include tactile sensation and proprioception. This paper reviews the tactile receptors and proprioceptors in human upper limb, the artificial sensors in upper limb prosthesis, and the sensory feedback technology used for reconstruction of lost sensory function in the amputee’s upper limb.

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Cairns, B. E., J. Liu та H. Wong. "Expression of α1 adrenergic receptor subtypes by afferent fibers that innervate rat masseter muscle". Scandinavian Journal of Pain 16, № 1 (2017): 167. http://dx.doi.org/10.1016/j.sjpain.2017.04.010.

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Abstract Aims In temporomandibular disorders sufferers, muscle pain is more severe in individuals who have undergone a traumatic stress. Why stress exacerbates masticatory muscle pain in these individuals is not known. One possibility is that under conditions of stress there is an interaction between the sympathetic and sensory nervous systems. This study investigated whether trigeminal ganglion neurons that innervate the masseter muscle express α1 adrenergic receptor subtypes to identify whether a direct interaction between the sympathetic and sensory nervous systems is feasible. Methods Mass

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Abuin, Liliane, Lucia L. Prieto-Godino, Haiyun Pan, et al. "In vivo assembly and trafficking of olfactory Ionotropic Receptors." BMC Biology 17, no. 1 (2019): 34. https://doi.org/10.1186/s12915-019-0651-7.

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<strong>Background: </strong>Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, IRs are thought to form heteromeric complexes that localise to the ciliated dendrites of sensory neurons. IR complexes are composed of selectively expressed 'tuning' receptors and one of two broadly expressed co-receptors (IR8a or IR25a). While the extracellular

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Lukasiewicz, Peter D., and Rachel O. L. Wong. "GABAC receptors on ferret retinal bipolar cells: A diversity of subtypes in mammals?" Visual Neuroscience 14, no. 5 (1997): 989–94. http://dx.doi.org/10.1017/s095252380001169x.

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AbstractThe GABAC receptor subtypes on bipolar cells of rats and cold-blooded vertebrates differ in their pharmacological properties and probably have different molecular compositions. With the exception of the rat, native GABAC receptors in mammals had not been studied. In ferret, whole-cell, voltage-clamp recordings were made from bipolar cells in the retinal slice preparation to determine which subtype of GABAC receptor predominated. Puff-evoked GABA currents in bipolar cells were partially reduced by the GABAA receptor antagonist bicuculline, indicating that both GABAA and GABAC receptors

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Kopp, U. C., and L. A. Smith. "Inhibitory renorenal reflexes: a role for renal prostaglandins in activation of renal sensory receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 6 (1991): R1513—R1521. http://dx.doi.org/10.1152/ajpregu.1991.261.6.r1513.

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In anesthetized rats, activation of renal sensory receptors with a mechanical stimulus (increased ureteral pressure) and a chemical stimulus (renal pelvic perfusion with 0.9 M NaCl) results in an increase in ipsilateral afferent renal nerve activity and a reflex increase in contralateral urine flow rate and urinary sodium excretion, i.e., a contralateral inhibitory renorenal reflex. Because both interventions are known to increase renal prostaglandin (PG) synthesis, we examined whether renal PGs were involved in the renorenal reflex response to renal sensory receptor stimulation. In the first

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Jiang, Yuan-Hong, Jia-Fong Jhang, Lori A. Birder, and Hann-Chorng Kuo. "Sensory Receptor, Inflammatory, and Apoptotic Protein Expression in the Bladder Urothelium of Patients with Different Subtypes of Interstitial Cystitis/Bladder Pain Syndrome." International Journal of Molecular Sciences 24, no. 1 (2023): 820. http://dx.doi.org/10.3390/ijms24010820.

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The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner’s interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The urothelia from the bladders of 52 NHIC patients were harvested. The expression of sensory receptors, including TRPV1, TRPV4, TRPA1, H1-receptors, and sigma-1 receptors; the inflammatory proteins p38 and tryptase; and the pro-apoptotic proteins, such as caspase-3, BAD, and BAX in the urothelium, were investigated using immun

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Zhao, Tianming, Qi Wang, and An Du. "Self-Powered Flexible Sour Sensor for Detecting Ascorbic Acid Concentration Based on Triboelectrification/Enzymatic-Reaction Coupling Effect." Sensors 21, no. 2 (2021): 373. http://dx.doi.org/10.3390/s21020373.

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Artificial sensory substitution systems can mimic human sensory organs through replacing the sensing process of a defective sensory receptor and transmitting the sensing signal into the nervous system. Here, we report a self-powered flexible gustation sour sensor for detecting ascorbic acid concentration. The material system comprises of Na2C2O4-Ppy with AAO modification, PDMS and Cu wire mesh. The working mechanism is contributed to the triboelectrification/enzymatic-reaction coupling effect, and the device can collect weak energy from body movements and directly output triboelectric current

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Zhao, Tianming, Qi Wang, and An Du. "Self-Powered Flexible Sour Sensor for Detecting Ascorbic Acid Concentration Based on Triboelectrification/Enzymatic-Reaction Coupling Effect." Sensors 21, no. 2 (2021): 373. http://dx.doi.org/10.3390/s21020373.

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Artificial sensory substitution systems can mimic human sensory organs through replacing the sensing process of a defective sensory receptor and transmitting the sensing signal into the nervous system. Here, we report a self-powered flexible gustation sour sensor for detecting ascorbic acid concentration. The material system comprises of Na2C2O4-Ppy with AAO modification, PDMS and Cu wire mesh. The working mechanism is contributed to the triboelectrification/enzymatic-reaction coupling effect, and the device can collect weak energy from body movements and directly output triboelectric current

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Salt, T. E. "Glutamate receptor functions in sensory relay in the thalamus." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 357, no. 1428 (2002): 1759–66. http://dx.doi.org/10.1098/rstb.2002.1165.

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It is known that glutamate is a major excitatory transmitter of sensory and cortical afferents to the thalamus. These actions are mediated via several distinct receptors with postsynaptic excitatory effects predominantly mediated by ionotropic receptors of the α–amino–3–hydroxy–5–methyl–4–isoxazolepropionate (AMPA) and N –methyl–D–aspartate varieties (NMDA). However, there are also other kinds of glutamate receptor present in the thalamus, notably the metabotropic and kainate types, and these may have more complex or subtle roles in sensory transmission. This paper describes recent electrophys

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Ichinose, M., H. Inoue, M. Miura, N. Yafuso, H. Nogami, and T. Takishima. "Possible sensory receptor of nonadrenergic inhibitory nervous system." Journal of Applied Physiology 63, no. 3 (1987): 923–29. http://dx.doi.org/10.1152/jappl.1987.63.3.923.

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To determine the sensory receptor of the nonadrenergic inhibitory nervous system (NAIS), 22 cats were anesthetized and serotonin was continuously administered (50–250 micrograms.kg-1.min-1 iv) to increase pulmonary resistance (RL) to 377 +/- 57% (SE) of the control value. We then 1) mechanically irritated the trachea, 2) intravenously administered capsaicin (5 micrograms/kg), or 3) induced hypoxia (arterial PO2 30–40 Torr) to stimulate irritant and bronchial C-fiber receptors, pulmonary C-fiber receptors, or the carotid body (chemoreceptors), respectively. After treatment with atropine (3 mg/k

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NAKAOKA, Yasuo. "Distribution of sensory receptors in Paramecium." Seibutsu Butsuri 28, no. 4 (1988): 194–97. http://dx.doi.org/10.2142/biophys.28.194.

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Uchida, Mitsuharu. "Sensory Receptors on Oral Thickness Sensation." JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN 66, no. 1 (1999): 1–7. http://dx.doi.org/10.5357/koubyou.66.1.

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Bele, Tanja, and Elsa Fabbretti. "P2X Receptors, Sensory Neurons and Pain." Current Medicinal Chemistry 22, no. 7 (2015): 845–50. http://dx.doi.org/10.2174/0929867321666141011195351.

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