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Rozprawy doktorskie na temat „Serine recombinase”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Malla, Sunir K. "Using site-specific serine recombinases as tools for chromosome engineering." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430624.

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Kobir, Ahasanul. "Physiological roles of Eukaryotic Hanks type Ser/Thr kinase in transition to stationary phase in Bacillus subtilis." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00911812.

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Bacillus subtilis is the model organism for low GC Gram-positive bacteria and is of great biotechnological interest. Protein phosphorylation is an important regulatory mechanism in bacteria and it has not been extensively studied yet. Recent site-specific phosphoproteomic studies identified a large number of novel serine/threonine phosphorylation sites in B. subtilis, including a) two transition phase global gene regulators DegS and AbrB and b) RecA, that plays a major role in double-strand break repair and DNA recombination. .B. subtilis disposes of several putative Ser/Thr kinases like PrkA,

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Marcello, Matthew R. "Analysis of recombinant human prostasin carrying a serine active site mutation." Honors in the Major Thesis, University of Central Florida, 2003. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/325.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Health and Public Affairs<br>Molecular Biology and Microbiology

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Santos, Juliete Vitorino dos. "Expressão e purificação da forma recombinante dos Inibidores de Serino Peptidase ISP1 e ISP2 de Leishmania infantum chagasi." reponame:Repositório Institucional da UFABC, 2017.

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Orientadora: Profª Drª Márcia Aparecida Sperança<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, 2017.<br>A leishmaniose visceral, causada pelos parasitas das espécies Leishmania infantum e Leishmania donovani, do Velho Mundo, e pela Leishmania infantum chagasi, do Novo Mundo, é uma doença infecciosa e letal se não for tratada. O número de casos desta doença está aumentando no Estado de São Paulo. Uma vez diagnosticada, o tratamento para a leishmaniose visceral tem efeitos colaterais importantes, além da ocorrência de parasitas resistentes ao

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Benchabane, Meriem. "Modifications post-traductionnelles d'une serpine humaine recombinante exprimée chez les plantes." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24868/24868.pdf.

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Benchabane, Meriem. "Modifications post-traductionnelles d’une serpine humaine recombinante exprimée chez les plantes." Rouen, 2007. http://www.theses.fr/2007ROUES020.

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Les plantes ont la capacité de produire des protéines recombinantes mais des problèmes de N-glycosylation et de protéolyse persistent. Afin d’établir l’impact de la localisation sur la stabilité et la glycosylation d'une protéine recombinante, nous avons exprimé l’inhibiteur de protéase α1-antichymotrypsine (AACT) humaine dans quatre compartiments (RE, vacuole, apoplasme et cytosol) de cellules de tabac en culture. Le produit obtenu s'est avéré être plus hétérogène au sein du système de sécrétion, en raison d'une maturation de la N-glycosylation et d'une maturation protéolytique. Inversement,

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Eilerts, Diane. "Recombinant Expression and Potential Autocatalysis of Aedes aegypti Trypsin-Like Serine Proteases (AaSPII and AaSPIV)." Thesis, San Jose State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10284010.

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<p> <i>Aedes aegypti</i> mosquitoes can be found globally in tropical and subtropical urban areas and spread Zika, Dengue fever, yellow fever, and Chikungunya viruses. Current vector control methods are limited and nonspecific. The female <i>Ae. aegypti</i> mosquito uses blood meal proteins to obtain nutrients required for oogenesis; inhibition of the midgut trypsin-like serine proteases responsible for blood meal digestion may provide a novel method of vector control. <i>Ae. aegypti</i> blood meal digestion is complex and the role of uncharacterized serine proteases in blood digestion is uncl

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Telli, Ilkin Ece. "Determination Of Metabolic Bottlenecks Using Reaction Engineering Principles In Serine Alkaline Protease Production By Recombinant Bacillus Species." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/12605227/index.pdf.

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In this study, firstly, bioprocess characteristics for Serine Alkaline Protease (SAP) production, using recombinant Bacillus subtilis carrying pHV1431::subC, were examined. The cell concentration, substrate concentration, SAP activity and SAP synthesis rate profiles demonstrated that the system reaches to a steady state in terms of cell growth and SAP synthesis between t=15-25 h, therefore, this time interval is appropriate to employ both metabolic flux analysis and metabolic control analysis, which apply strictly to steady state systems. After that, three separate perturbations were intr

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Andrade, Regina Aparecida de. "Desenvolvimento de Vioserpina para estudo de especificidade e inibição da calicreína tecidual humana 5 recombinante, utilizando mutantes da vioserpina." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Luciano Puzer<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, São Bernardo do Campo, 2017.<br>Serpina é o nome dado à superfamília de proteínas com uma vasta diversidade de funções biológicas, que tem como principal característica a inibição irreversível de serino proteases. A característica estrutural mais marcante das serpinas é a presença de uma alça na sua porção C-terminal, composta por 20 aminoácidos denominados alça do centro reativo (RCL). A RCL é a região da serpina que se liga covalentemente ao sítio ativo da s

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10

Rascon, Alberto, Johnathon Gearin, Jun Isoe, and Roger Miesfeld. "In vitro activation and enzyme kinetic analysis of recombinant midgut serine proteases from the Dengue vector mosquito Aedes aegypti." BioMed Central, 2011. http://hdl.handle.net/10150/610098.

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BACKGROUND:The major Dengue virus vector Aedes aegypti requires nutrients obtained from blood meal proteins to complete the gonotrophic cycle. Although bioinformatic analyses of Ae. aegypti midgut serine proteases have provided evolutionary insights, very little is known about the biochemical activity of these digestive enzymes.RESULTS:We used peptide specific antibodies to show that midgut serine proteases are expressed as zymogen precursors, which are cleaved to the mature form after blood feeding. Since midgut protein levels are insufficient to purify active proteases directly from blood fe

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11

BELORGEY, DIDIER. "Influence de l'adn et de differents polynucleotides sur l'inhibition des serine-proteases leucocytaires humaines. Effet de la dnase recombinante." Université Louis Pasteur (Strasbourg) (1971-2008), 1996. http://www.theses.fr/1996STR13200.

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La mucoviscidose se caracterise, au niveau pulmonaire, par une accumulation de mucus purulent, une obstruction des voies aeriennes et une inflammation conduisant a une detresse respiratoire et finalement a la mort. Au cours de l'inflammation, les neutrophiles vont liberer differentes proteases. D'un autre cote, la quantite importante d'adn derivee de ces neutrophiles augmente la viscosite des secretions bronchiques. Le present travail vise a montrer le role de l'adn dans l'inhibition de l'elastase leucocytaire et des autres proteases contenues dans les granules azurophiles du neutrophile, la c

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Silva, Kelly Pereira da. "Clonagem, expressão recombinante e caracterização de uma serpina da cana-de-açúcar." Universidade Federal de São Carlos, 2008. https://repositorio.ufscar.br/handle/ufscar/5452.

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Made available in DSpace on 2016-06-02T20:21:21Z (GMT). No. of bitstreams: 1 2016.pdf: 1206354 bytes, checksum: fc07f54941a23475ae348908f318c08a (MD5) Previous issue date: 2008-08-29<br>Financiadora de Estudos e Projetos<br>As serpinas são conhecidos inibidores de serino proteases, enzimas notáveis por participarem de inúmeros processos fisiológicos importantes. A proteólise não regulada pode levar ao surgimento de doenças e problemas funcionais e, portanto, a função dos inibidores é fundamental para o bom funcionamento do organismo. No genoma da cana-de-açúcar foi identificada uma ORF (Open

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13

Oktar, Ceren. "Comparative Analysis Of Product And By-product Distributions In Defined And Complex Media In Serine Alkaline Protease Production By Recombinant Bacillus Subtilis." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/1262880/index.pdf.

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In this study, firstly the effects of aspartic acid group amino acids -which were reported to be the potential bottleneck in serine alkaline protease (SAP) synthesis- on SAP production were investigated by substituting at a concentration range of 0-15 mM by using recombinant Bacillus subtilis carrying pHV1434::subC gene. All aspartic acid group amino acids except threonine inhibited SAP activity when CAA&amp<br>#8805<br>2.5 mM. The highest SAP activities with asparagine, aspartic acid, lysine, threonine, isoleucine and methionine werefound to be 1.89-, 1.87-, 1.61-, 1.48-, 1.4-, and 1.4-fold h

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14

Dahl, Mads Ronald. "Mannan-binding lectin (MBL) associated serine protease-3 (MASP-3) : complex formation in serum and plasma, conditions required for the conversion of the zymogen form into a two-chain serin protease, and a search for substrates using recombinant material produced by stable expression in eukaryotic cell lines." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29483.

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The complement system is part of the innate immune system and is crucial for identifying invading microorganisms. The lectin pathway of complement activation is initiated through multimeric macromolecules which recognise pathogen-associated patterns and translate binding through activation of associated serine proteases that start a cascade of proteolytic events leading to bactericidal, opsonising and proinflammatory responses. Mannan-binding lectin (MBL) is one of the macromolecules mediating binding to specific carbohydrate structures common to a range of microorganisms. Three different mann

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Saeed, Bayad Mawlood. "The role of mannose binding lectin associated serine protease MASP-3 in complement mediated haemolysis and the utility of recombinant properdin in fighting Streptococcus pneumoniae infection." Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/39354.

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Complement is a part of our innate immune defence system and plays an important role in fighting infection and maintaining the integrity of our body. Complement activation is tightly regulated through complement regulators, which allow their activation on foreign cells, like pathogens and stop their activation on self-cells. In states that complement activation causes damage to the self-cells (unwanted complement activation on self-cell) that arises due to deficiency of complement regulators, down regulating complement system is essential. In this condition, targeting specific pathway of compl

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16

MONNOT, JACQUARD BENEDICTE. "Traitement de l'hepatite chronique post-virale b par l'association vidarabine monophosphate - interferon alpha recombinant : resultats preliminaires obtenus dans une serie de 13 patients." Besançon, 1994. http://www.theses.fr/1994BESA3027.

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Costa, Guilherme Nunes Moreira. "Expressão e caracterização bioquímica parcial de uma serinoprotease recombinante da peçonha de Bothrops pauloensis." Universidade Federal de Uberlândia, 2014. https://repositorio.ufu.br/handle/123456789/15888.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>CHAPTER II: The snake venom is composed by a diversity of biomolecules with many actions on physiological processes. The serine peptidases are a group of proteases present in the constitution of the venom, capable of interfering on several points of hemostasis. Some serine peptidases has thrombin-like activity, what makes them targets on the development of therapeutics agentes on the treatment of many hemostatic disorders. In this study, a recombinant thrombin-like serine peptidase called rBpSP-II was obtained from the cDNA of th

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Cartier, Anna. "Inhibition of apoptosis by the Us3 protein kinase of herpes simplex virus 1 /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-022-2/.

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Smith, Eliot T. "Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1198.

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The yeasts Pichia pastoris and Kluyveromyces lactis were used to express several recombinant human proteins for further biochemical characterization. Two substitution variants of recombinant human enteropeptidase light chain (rhEPL) were engineered to modify the extended substrate specificity of this serine protease. Both were secreted as active enzymes in excess of 1.7 mg/L in P. pastoris fermentation broth. The substitution variant rhEPL R96Q showed significantly reduced specificities for the preferred substrate sequences DDDDK and DDDDR; however, the rhEPL Y174R variant displayed improved s

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Leahy, Darren. "Probing the role of methionine oxidation in substrate and inhibitor interactions with native and recombinant Human Neutrophil Elastase." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/204141/1/Darren_Leahy_Thesis.pdf.

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This thesis was an exploration of how Human Neutrophil Elastase (HNE) activity can be modulated by oxidation of methionine residues located on substrates and inhibitors. Research focused on producing a molecular toolbox of innovative HNE substrates and inhibitors specifically engineered to include methionine, then assessing the mechanism by which oxidation leads to targeted interaction with HNE. This may be an important biochemical process in chronic obstructive pulmonary disease, which is linked to HNE destruction of elastic lung tissue together with oxidative damage by cigarette smoke and ne

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Kamali-Moghaddam, Masood. "Co-operative recombination mechanisms promoting gene clustering and lateral transfer of antibacterial drug resistance." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4936-0/.

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Kao, Min-Hsung, and 高敏軒. "The overexpression of recombinant serine protease from Vibrio parahaemolyticus." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/58549807112019590740.

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碩士<br>國立臺灣大學<br>農業化學研究所<br>94<br>Blast against Vibrio parahaemolyticus genome database with the N-terminal sequence of mature protease A purified from V. parahaemolyticus No.93 and the ORF VPA0227 located on chromosome 2 was matched. The ORF VPA0227 has 2,034 base pairs in nucleic acid and 677 amino acids in protein. To study over-expression of protease A, several primers were designed for cloning different length of prtA. The entire prtA containing signal peptide sequence was cloned, and the recombinant proteases were secreted out of E. coli cells. When used azocoll as substrate, the proteas

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"Modifications post-traductionnelles d'une serpine humaine recombinante exprimée chez les plantes." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24868/24868.pdf.

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Su, Xiang-Ping, and 蘇香萍. "Characteristics of the Recombinant Alkaline Serine Protease from Bacillus licheniformis and its Application on Rice Proteins." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/37251550169290647957.

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Glauser, Daniel Lucas. "Role of booster injections and individual interferon systems on shaping of IgG subclass profiles in mice immunized with a recombinant bovine herpesvirus type 1 /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012967455&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Razai, Noushin. "Prospektive Verlaufsstudie zur nachhaltigen Wirksamkeit der intravenösen systematischen Thrombolyse mit recombinant tissue plasminogen activator (rt-PA) bei Patienten mit akutem Hirninfarkt im klinischen Alltag /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013076461&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Rybáriková, Renata. "Rekombinantní exprese a funkční charakterizace rostlinných Kunitzových inhibitorů." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-449050.

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PDI ("potato cathepsin D inhibitor ") and NID ("novel inhibitor of cathepsin D ") from potato (Solanum tuberosum) belong to the protein family of Kunitz inhibitors (I3 family, Merops database). These 20 kDa isoinhibitors with the typical β-trefoil architecture inhibit aspartic and serine peptidases. In this thesis, the constructs for recombinant expression of PDI and NID in the yeast Pichia pastoris system were prepared and high-producing colonies were selected. Both proteins were identified in the cultivation media by mass spectrometry and N-terminal sequencing. A purification protocol for PD

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