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Artykuły w czasopismach na temat „Serine recombinase”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Marshall Stark, W., Martin R. Boocock, Femi J. Olorunniji, and Sally-J. Rowland. "Intermediates in serine recombinase-mediated site-specific recombination." Biochemical Society Transactions 39, no. 2 (2011): 617–22. http://dx.doi.org/10.1042/bst0390617.

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Site-specific recombinases are enzymes that promote precise rearrangements of DNA sequences. They do this by cutting and rejoining the DNA strands at specific positions within a pair of target sites recognized and bound by the recombinase. One group of these enzymes, the serine recombinases, initiates strand exchange by making double-strand breaks in the DNA of the two sites, in an intermediate built around a catalytic tetramer of recombinase subunits. However, these catalytic steps are only the culmination of a complex pathway that begins when recombinase subunits recognize and bind to their

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2

Rice, Phoebe A., Kent W. Mouw, Sherwin P. Montaño, Martin R. Boocock, Sally-J. Rowland, and W. Marshall Stark. "Orchestrating serine resolvases." Biochemical Society Transactions 38, no. 2 (2010): 384–87. http://dx.doi.org/10.1042/bst0380384.

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A remarkable feature of the serine resolvases is their regulation: the wild-type enzymes will catalyse intra- but not inter-molecular recombination, can sense the relative orientation of their sites and can exchange strands directionally, despite the fact that there is no net release of chemical bond energy. The key to this regulation is that they are only active within a large intertwined complex called the ‘synaptosome’. Because substrate topology greatly facilitates (or, in other cases, inhibits) formation of the synaptosome, it acts as a ‘topological filter’. Within the defined topology of

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3

Mouw, Kent W., Sally-J. Rowland, Mark M. Gajjar, Martin R. Boocock, W. Marshall Stark, and Phoebe A. Rice. "Architecture of a Serine Recombinase-DNA Regulatory Complex." Molecular Cell 30, no. 2 (2008): 145–55. http://dx.doi.org/10.1016/j.molcel.2008.02.023.

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4

Van Duyne, Gregory D., and Karen Rutherford. "Large serine recombinase domain structure and attachment site binding." Critical Reviews in Biochemistry and Molecular Biology 48, no. 5 (2013): 476–91. http://dx.doi.org/10.3109/10409238.2013.831807.

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5

Gaj, T., A. C. Mercer, C. A. Gersbach, R. M. Gordley, and C. F. Barbas. "Structure-guided reprogramming of serine recombinase DNA sequence specificity." Proceedings of the National Academy of Sciences 108, no. 2 (2010): 498–503. http://dx.doi.org/10.1073/pnas.1014214108.

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6

Keenholtz, Ross A., Sally-J. Rowland, Martin R. Boocock, W. Marshall Stark, and Phoebe A. Rice. "Structural Basis for Catalytic Activation of a Serine Recombinase." Structure 19, no. 6 (2011): 799–809. http://dx.doi.org/10.1016/j.str.2011.03.017.

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7

Rutherford, Karen, Kushol Gupta, and Gregory Van Duyne. "Solution Scattering Studies of Large Serine Recombinase-DNA Complexes." Biophysical Journal 104, no. 2 (2013): 368a. http://dx.doi.org/10.1016/j.bpj.2012.11.2046.

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8

Bibb, Lori A., Maria I. Hancox та Graham F. Hatfull. "Integration and excision by the large serine recombinase φRv1 integrase". Molecular Microbiology 55, № 6 (2005): 1896–910. http://dx.doi.org/10.1111/j.1365-2958.2005.04517.x.

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9

Sirk, Shannon J., Thomas Gaj, Andreas Jonsson, Andrew C. Mercer, and Carlos F. Barbas. "Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants." Nucleic Acids Research 42, no. 7 (2014): 4755–66. http://dx.doi.org/10.1093/nar/gkt1389.

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10

Shao, Min, Shashi Kumar, and James G. Thomson. "Precise excision of plastid DNA by the large serine recombinase Bxb1." Plant Biotechnology Journal 12, no. 3 (2013): 322–29. http://dx.doi.org/10.1111/pbi.12139.

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11

Askora, Ahmed, Takeru Kawasaki, Makoto Fujie та Takashi Yamada. "Resolvase-like serine recombinase mediates integration/excision in the bacteriophage ϕRSM". Journal of Bioscience and Bioengineering 111, № 2 (2011): 109–16. http://dx.doi.org/10.1016/j.jbiosc.2010.10.001.

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12

Hiraizumi, Masahiro, Nicholas T. Perry, Matthew G. Durrant, et al. "Structural mechanism of bridge RNA-guided recombination." Nature 630, no. 8018 (2024): 994–1002. http://dx.doi.org/10.1038/s41586-024-07570-2.

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AbstractInsertion sequence (IS) elements are the simplest autonomous transposable elements found in prokaryotic genomes1. We recently discovered that IS110 family elements encode a recombinase and a non-coding bridge RNA (bRNA) that confers modular specificity for target DNA and donor DNA through two programmable loops2. Here we report the cryo-electron microscopy structures of the IS110 recombinase in complex with its bRNA, target DNA and donor DNA in three different stages of the recombination reaction cycle. The IS110 synaptic complex comprises two recombinase dimers, one of which houses th

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13

Keenholtz, Ross A., Kent W. Mouw, Martin R. Boocock, Nan-Sheng Li, Joseph A. Piccirilli, and Phoebe A. Rice. "Arginine as a General Acid Catalyst in Serine Recombinase-mediated DNA Cleavage." Journal of Biological Chemistry 288, no. 40 (2013): 29206–14. http://dx.doi.org/10.1074/jbc.m113.508028.

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14

Wang, Hongmei, Margaret C. M. Smith, and Peter Mullany. "The Conjugative Transposon Tn5397 Has a Strong Preference for Integration into Its Clostridium difficile Target Site." Journal of Bacteriology 188, no. 13 (2006): 4871–78. http://dx.doi.org/10.1128/jb.00210-06.

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ABSTRACT Tn5397 is a conjugative transposon, originally isolated from Clostridium difficile. The Tn5397 transposase TndX is related to the phage-encoded serine integrases and the Clostridium perfringens Tn4451 transposase TnpX. TndX is required for the insertion and excision of the transposon. Tn5397 inserts at one locus, attBCd , in C. difficile but at multiple sites in Bacillus subtilis. Apart from a conserved 5′ GA dinucleotide at the recombination site, there appears to be little sequence conservation between the known target sites. To test the target site preference of Tn5397, attBCd was

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15

Bland, Michael J., Magaly Ducos-Galand, Marie-Eve Val, and Didier Mazel. "An att site-based recombination reporter system for genome engineering and synthetic DNA assembly." BMC Biotechnology 17, no. 1 (2017): 62. https://doi.org/10.1186/s12896-017-0382-1.

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<strong>Background: </strong>Direct manipulation of the genome is a widespread technique for genetic studies and synthetic biology applications. The tyrosine and serine site-specific recombination systems of bacteriophages HK022 and ΦC31 are widely used for stable directional exchange and relocation of DNA sequences, making them valuable tools in these contexts. We have developed site-specific recombination tools that allow the direct selection of recombination events by embedding the <i>attB</i> site from each system within the β-lactamase resistance coding sequence (<i>bla</i>).<strong>Resul

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16

Rowley, Paul A., та Margaret C. M. Smith. "Role of the N-Terminal Domain of φC31 Integrase in attB-attP Synapsis". Journal of Bacteriology 190, № 20 (2008): 6918–21. http://dx.doi.org/10.1128/jb.00612-08.

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ABSTRACT φC31 integrase is a serine recombinase containing an N-terminal domain (NTD) that provides catalytic activity and a large C-terminal domain that controls which pair of DNA substrates is able to synapse. We show here that substitutions in amino acid V129 in the NTD can lead to defects in synapsis and DNA cleavage, indicating that the NTD also has an important role in synapsis.

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17

Hartmann, Thomas, Michaela Dümig, Basem M. Jaber та ін. "Validation of a Self-Excising Marker in the Human Pathogen Aspergillus fumigatus by Employing the β-Rec/six Site-Specific Recombination System". Applied and Environmental Microbiology 76, № 18 (2010): 6313–17. http://dx.doi.org/10.1128/aem.00882-10.

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ABSTRACT Recyclable markers based on site-specific recombination allow repetitive gene targeting in filamentous fungi. Here we describe for the first time functionality of the bacterial recombination system employing β serine recombinase acting on six recognition sequences (β-rec/six) in a fungal host, the human pathogen Aspergillus fumigatus, and its use in establishing a self-excising resistance marker cassette for serial gene replacement.

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18

Mandali, Sridhar, Gautam Dhar, Nuraly K. Avliyakulov, Michael J. Haykinson, and Reid C. Johnson. "The site-specific integration reaction of Listeria phage A118 integrase, a serine recombinase." Mobile DNA 4, no. 1 (2013): 2. http://dx.doi.org/10.1186/1759-8753-4-2.

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19

Lucet, Isabelle S., Fleur E. Tynan, Vicki Adams, Jamie Rossjohn, Dena Lyras, and Julian I. Rood. "Identification of the Structural and Functional Domains of the Large Serine Recombinase TnpX fromClostridium perfringens." Journal of Biological Chemistry 280, no. 4 (2004): 2503–11. http://dx.doi.org/10.1074/jbc.m409702200.

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20

Bai, H., M. Sun, P. Ghosh, G. F. Hatfull, N. D. F. Grindley, and J. F. Marko. "Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase." Proceedings of the National Academy of Sciences 108, no. 18 (2011): 7419–24. http://dx.doi.org/10.1073/pnas.1018436108.

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21

Herisse, Marion, Jessica L. Porter, Romain Guerillot та ін. "The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia". PeerJ 6 (4 травня 2018): e4784. http://dx.doi.org/10.7717/peerj.4784.

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Plasmid vectors based on bacteriophage integrases are important tools in molecular microbiology for the introduction of foreign DNA, especially into bacterial species where other systems for genetic manipulation are limited. Site specific integrases catalyze recombination between phage and bacterial attachment sites (attP and attB, respectively) and the best studied integrases in the actinomycetes are the serine integrases from the Streptomyces bacteriophages ΦC31 and ΦBT1. As this reaction is unidirectional and highly stable, vectors containing phage integrase systems have been used in a numb

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22

Combes, Patricia, Rob Till, Sally Bee та Margaret C. M. Smith. "The Streptomyces Genome Contains Multiple Pseudo-attB Sites for the φC31-Encoded Site-Specific Recombination System". Journal of Bacteriology 184, № 20 (2002): 5746–52. http://dx.doi.org/10.1128/jb.184.20.5746-5752.2002.

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ABSTRACT The integrase from the Streptomyces phage φC31 is a member of the serine recombinase family of site-specific recombinases and is fundamentally different from that of λ or its relatives. Moreover, φC31 int/attP is used widely as an essential component of integration vectors (such as pSET152) employed in the genetic analysis of Streptomyces species. φC31 or integrating plasmids containing int/attP have been shown previously to integrate at a locus, attB, in the chromosome. The DNA sequences of the attB sites of various Streptomyces species revealed nonconserved positions. In particular,

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23

Keenholtz, Ross A., Nigel D. F. Grindley, Graham F. Hatfull, and John F. Marko. "Crossover-site sequence and DNA torsional stress control strand interchanges by the Bxb1 site-specific serine recombinase." Nucleic Acids Research 44, no. 18 (2016): 8921–32. http://dx.doi.org/10.1093/nar/gkw724.

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24

Adams, Vicki, Isabelle S. Lucet, Fleur E. Tynan, et al. "Two distinct regions of the large serine recombinase TnpX are required for DNA binding and biological function." Molecular Microbiology 60, no. 3 (2006): 591–601. http://dx.doi.org/10.1111/j.1365-2958.2006.05120.x.

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25

Yamada, Yohko, Mari Maeda, Mohamed Mahdi Alshahni, Michel Monod, Peter Staib, and Tsuyoshi Yamada. "Flippase (FLP) recombinase-mediated marker recycling in the dermatophyte Arthroderma vanbreuseghemii." Microbiology 160, no. 10 (2014): 2122–35. http://dx.doi.org/10.1099/mic.0.076562-0.

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Biological processes can be elucidated by investigating complex networks of relevant factors and genes. However, this is not possible in species for which dominant selectable markers for genetic studies are unavailable. To overcome the limitation in selectable markers for the dermatophyte Arthroderma vanbreuseghemii (anamorph: Trichophyton mentagrophytes), we adapted the flippase (FLP) recombinase-recombination target (FRT) site-specific recombination system from the yeast Saccharomyces cerevisiae as a selectable marker recycling system for this fungus. Taking into account practical applicabil

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26

Wang, Yali, Mengke Guo, Naisu Yang, et al. "Phylogenetic Relationships among TnpB-Containing Mobile Elements in Six Bacterial Species." Genes 14, no. 2 (2023): 523. http://dx.doi.org/10.3390/genes14020523.

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Some families of mobile elements in bacterial genomes encode not only a transposase but also an accessory TnpB gene. This gene has been shown to encode an RNA-guided DNA endonuclease, co-evolving with Y1 transposase and serine recombinase in mobile elements IS605 and IS607. In this paper, we reveal the evolutionary relationships among TnpB-containing mobile elements (TCMEs) in well-assembled genomes of six bacterial species: Bacillus cereus, Clostridioides difficile, Deinococcus radiodurans, Escherichia coli, Helicobacter pylori and Salmonella enterica. In total, 9996 TCMEs were identified in

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27

Buchner, John M., Anne E. Robertson, David J. Poynter, Shelby S. Denniston, and Anna C. Karls. "Piv Site-Specific Invertase Requires a DEDD Motif Analogous to the Catalytic Center of the RuvC Holliday Junction Resolvases." Journal of Bacteriology 187, no. 10 (2005): 3431–37. http://dx.doi.org/10.1128/jb.187.10.3431-3437.2005.

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ABSTRACT Piv, a unique prokaryotic site-specific DNA invertase, is related to transposases of the insertion elements from the IS110/IS492 family and shows no similarity to the site-specific recombinases of the tyrosine- or serine-recombinase families. Piv tertiary structure is predicted to include the RNase H-like fold that typically encompasses the catalytic site of the recombinases or nucleases of the retroviral integrase superfamily, including transposases and RuvC-like Holliday junction resolvases. Analogous to the DDE and DEDD catalytic motifs of transposases and RuvC, respectively, four

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28

Ritacco, Christopher J., Thomas A. Steitz, and Jimin Wang. "Exploiting large non-isomorphous differences for phase determination of a G-segment invertase–DNA complex." Acta Crystallographica Section D Biological Crystallography 70, no. 3 (2014): 685–93. http://dx.doi.org/10.1107/s1399004713032392.

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Crystals of the G-segment invertase in complex with a 37-base-pair asymmetric DNA duplex substrate had an unusually high solvent content of 88% and diffracted to a maximal resolution of about 5.0 Å. These crystals exhibited a high degree of non-isomorphism and anisotropy, which presented a serious challenge for structure determination by isomorphous replacement. Here, a procedure of cross-crystal averaging is described that uses large non-isomorphous crystallographic data witha prioriinformation of an approximate molecular boundary as determined from a minimal amount of experimental phase info

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Bidnenko, Vladimir, Lei Shi, Ahasanul Kobir, et al. "B acillus subtilis serine/threonine protein kinase YabT is involved in spore development via phosphorylation of a bacterial recombinase." Molecular Microbiology 88, no. 5 (2013): 921–35. http://dx.doi.org/10.1111/mmi.12233.

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30

Senkevich, Tatiana G., Eugene V. Koonin, and Bernard Moss. "Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli." Virology 417, no. 2 (2011): 334–42. http://dx.doi.org/10.1016/j.virol.2011.06.017.

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Fan, Hsiu-Fang, Bo-Yu Su, Chien-Hui Ma, Paul A. Rowley, and Makkuni Jayaram. "A bipartite thermodynamic-kinetic contribution by an activating mutation to RDF-independent excision by a phage serine integrase." Nucleic Acids Research 48, no. 12 (2020): 6413–30. http://dx.doi.org/10.1093/nar/gkaa401.

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Abstract Streptomyces phage ϕC31 integrase (Int)—a large serine site-specific recombinase—is autonomous for phage integration (attP x attB recombination) but is dependent on the phage coded gp3, a recombination directionality factor (RDF), for prophage excision (attL x attR recombination). A previously described activating mutation, E449K, induces Int to perform attL x attR recombination in the absence of gp3, albeit with lower efficiency. E449K has no adverse effect on the competence of Int for attP x attB recombination. Int(E449K) resembles Int in gp3 mediated stimulation of attL x attR reco

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Yang, Qiaoyan, Qian Zhu, Xiaopeng Lu, et al. "G9a coordinates with the RPA complex to promote DNA damage repair and cell survival." Proceedings of the National Academy of Sciences 114, no. 30 (2017): E6054—E6063. http://dx.doi.org/10.1073/pnas.1700694114.

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Histone methyltransferase G9a has critical roles in promoting cancer-cell growth and gene suppression, but whether it is also associated with the DNA damage response is rarely studied. Here, we report that loss of G9a impairs DNA damage repair and enhances the sensitivity of cancer cells to radiation and chemotherapeutics. In response to DNA double-strand breaks (DSBs), G9a is phosphorylated at serine 211 by casein kinase 2 (CK2) and recruited to chromatin. The chromatin-enriched G9a can then directly interact with replication protein A (RPA) and promote loading of the RPA and Rad51 recombinas

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Zhang, Lin, Xijun Ou, Guoping Zhao та Xiaoming Ding. "Highly Efficient In Vitro Site-Specific Recombination System Based on Streptomyces Phage φBT1 Integrase". Journal of Bacteriology 190, № 19 (2008): 6392–97. http://dx.doi.org/10.1128/jb.00777-08.

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ABSTRACT The Streptomyces phage φBT1 encodes a site-specific integrase of the large serine recombinase subfamily. In this report, the enzymatic activity of the φBT1 integrase was characterized in vitro. We showed that this integrase has efficient integration activity with substrate DNAs containing attB and attP sites, independent of DNA supercoiling or cofactors. Both intra- and intermolecular recombinations proceed with rapid kinetics. The recombination is highly specific, and no reactions are observed between pairs of sites including attB and attL, attB and attR, attP and attL, or attP and a

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Qiu, Minli, Liudan Tu, Minjing Zhao, et al. "Ataxia-televangelist mutated (ATM)/ ATR serine/threonine kinase (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic differentiation and inhibits osteoclastogenesis in osteoporosis." Bioengineered 13, no. 2 (2022): 4201–11. http://dx.doi.org/10.1080/21655979.2022.2026729.

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Olorunniji, Femi J., Arlene L. McPherson, Hania J. Pavlou, et al. "Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages." Nucleic Acids Research 43, no. 12 (2015): 6134–43. http://dx.doi.org/10.1093/nar/gkv521.

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Murphy, Ronan A., and E. Fidelma Boyd. "Three Pathogenicity Islands of Vibrio cholerae Can Excise from the Chromosome and Form Circular Intermediates." Journal of Bacteriology 190, no. 2 (2007): 636–47. http://dx.doi.org/10.1128/jb.00562-07.

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ABSTRACT Vibrio pathogenicity island-2 (VPI-2) is a 57-kb region integrated at a transfer RNA (tRNA)-serine locus that encompasses VC1758 to VC1809 on the V. cholerae N16961 genome and is present in pandemic isolates. VPI-2 encodes a P4-like integrase, a restriction modification system, a Mu phage-like region, and a sialic acid metabolism region, as well as neuraminidase (VC1784), which is a glycosylhydrolase known to release sialic acid from sialoglycoconjugates to unmask GM1 gangliosides, the receptor for cholera toxin. We examined the tRNA-serine locus among the sequenced V. cholerae genome

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Hewitt, Susannah, Suzzette Arnal, Ludovic Deriano, David Roth, and Jane Skok. "Control of RAG Cleavage Activity Contributes to Maintaining Genome Stability During V(D)J Recombination." Blood 118, no. 21 (2011): 2416. http://dx.doi.org/10.1182/blood.v118.21.2416.2416.

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Abstract Abstract 2416 Acute lymphoblastic leukemia (ALL) results from malignancy of lymphoid progenitor cells and affects both adults and children. It is the most common childhood cancer and despite advances in treatment that now result in above 80% cure rates for children, considerable problems remain with current therapies. These include low cure rates in children with high-risk ALL, the complexity and toxic effects of current treatments and the stubbornly poor prognosis of adults with ALL (with a less than 40% long-term survival rate). ALL can be initiated by errors in V(D)J recombination,

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Odekunle, Israel Ifeoluwa, Sydney Remington, Allison Racela, and David J. Seward. "Abstract 7227: An inducible, spatially restricted mouse model of lung cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 7227. https://doi.org/10.1158/1538-7445.am2025-7227.

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Abstract Accurately modeling human lung tumor initiation and progression in genetically engineered mouse models (GEMMs) remains a challenge. In contrast to human lung cancer development, where patients typically present with a solitary tumor nodule, the majority of GEMMs produce numerous independent primary lung lesions. Each of these lesions then evolves as an independent tumor, a situation not relevant to human lung cancer biology. The Cre-loxP recombination system is widely used to generate GEMMs, including the inducible, tamoxifen-dependent systems that allow cell-specific conditional acti

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Bjørkeng, Eva Katrin, Girum Tadesse Tessema, Eirik Wasmuth Lundblad, et al. "ccrAB Ent serine recombinase genes are widely distributed in the Enterococcus faecium and Enterococcus casseliflavus species groups and are expressed in E. faecium." Microbiology 156, no. 12 (2010): 3624–34. http://dx.doi.org/10.1099/mic.0.041491-0.

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The presence, distribution and expression of cassette chromosome recombinase (ccr) genes, which are homologous to the staphylococcal ccrAB genes and are designated ccrAB Ent genes, were examined in enterococcal isolates (n=421) representing 13 different species. A total of 118 (28 %) isolates were positive for ccrAB Ent genes by PCR, and a number of these were confirmed by Southern hybridization with a ccrA Ent probe (n=76) and partial DNA sequencing of ccrA Ent and ccrB Ent genes (n=38). ccrAB Ent genes were present in Enterococcus faecium (58/216, 27 %), Enterococcus durans (31/38, 82 %), En

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40

Sible, Emily, Mary Attaway, Tzippora Chwat, et al. "Elucidating the role of ATM in BER and MMR during B cell CSR." Journal of Immunology 206, no. 1_Supplement (2021): 63.17. http://dx.doi.org/10.4049/jimmunol.206.supp.63.17.

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Abstract Secondary immunoglobulin isotypes are produced by class switch recombination (CSR), which requires AID-dependent DNA deamination of intronic switch (S) regions within the immunoglobulin heavy chain gene. Non-canonical repair of deaminated DNA by mismatch repair (MMR) or base excision repair (BER) creates staggered DNA breaks that promote recombination between S regions. ATM-dependent phosphorylation of AID at serine-38 (pS38-AID) promotes its interaction with APE1, a BER protein, suggesting that ATM regulates CSR through BER. However, pS38-AID may also play a role in MMR during CSR, a

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41

Sible, Emily, Giuseppe Fiorica, Sadia Rahman, Mary Attaway, and Bao Q. Vuong. "Elucidating the role of ATM in BER and MMR during B cell CSR." Journal of Immunology 204, no. 1_Supplement (2020): 151.1. http://dx.doi.org/10.4049/jimmunol.204.supp.151.1.

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Abstract Secondary immunoglobulin isotypes are produced by class switch recombination (CSR), which requires AID-dependent DNA deamination of intronic switch (S) regions within the immunoglobulin heavy chain gene. Non-canonical repair of deaminated DNA by mismatch repair (MMR) or base excision repair (BER) creates staggered DNA breaks that promote recombination between S regions. ATM-dependent phosphorylation of AID at serine-38 (pS38-AID) promotes its interaction with a BER protein, suggesting that ATM regulates CSR through BER. However, the mechanism by which ATM participates in BER remains u

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Burgener, Sabrina S., Mathias Baumann, Paola Basilico, Eileen Remold-O’Donnell, Ivo P. Touw, and Charaf Benarafa. "Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1." Biological Chemistry 397, no. 9 (2016): 897–905. http://dx.doi.org/10.1515/hsz-2016-0132.

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Abstract Serpinb1 is an inhibitor of neutrophil granule serine proteases cathepsin G, proteinase-3 and elastase. One of its core physiological functions is to protect neutrophils from granule protease-mediated cell death. Mice lacking Serpinb1a (Sb1a-/-), its mouse ortholog, have reduced bone marrow neutrophil numbers due to cell death mediated by cathepsin G and the mice show increased susceptibility to lung infections. Here, we show that conditional deletion of Serpinb1a using the Lyz2-cre and Cebpa-cre knock-in mice effectively leads to recombination-mediated deletion in neutrophils but pro

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Sun, Tianhe, та Ursula Storb. "Insertion of Phosphoglycerine Kinase (Pgk)-Neo 5′ of Jλ1 Dramatically Enhances Vjλ1 Rearrangement". Journal of Experimental Medicine 193, № 6 (2001): 699–712. http://dx.doi.org/10.1084/jem.193.6.699.

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Gene-targeted mice were generated with a loxP-neomycin resistance gene (neor) cassette inserted upstream of the Jλ1 region and replacement of the glycine 154 codon in the Cλ1 gene with a serine codon. This insertion dramatically increases Vλ1-Jλ1 recombination. Jλ1 germline transcription levels in pre-B cells and thymus cells are also greatly increased, apparently due to the strong housekeeping phosphoglycerine kinase (PGK) promoter driving the neo gene. In contrast, deletion of the neo gene causes a significant decrease in VJλ1 recombination to levels below those in normal mice. This reductio

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Fang, Kuan-Te, Hsin Hung, Nga Yin Sadonna Lau, Jou-Hsi Chi, Deng-Chyang Wu, and Kuang-Hung Cheng. "Development of a Genetically Engineered Mouse Model Recapitulating LKB1 and PTEN Deficiency in Gastric Cancer Pathogenesis." Cancers 15, no. 24 (2023): 5893. http://dx.doi.org/10.3390/cancers15245893.

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The LKB1 and PTEN genes are critical in gastric cancer (G.C.) development. LKB1, a robust tumor suppressor gene, encodes a serine/threonine kinase that directly triggers the activation of AMPK—an integral cellular metabolic kinase. The role of the LKB1 pathway extends to maintaining the stability of epithelial junctions by regulating E-cadherin expression. Conversely, PTEN, a frequently mutated tumor suppressor gene in various human cancers, emerges as a pivotal negative regulator of the phosphoinositide 3-kinase (PI3K) signaling pathway. This study is set to leverage the H+/K+ ATPase Cre tran

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Hoevelmeyer, Nadine, Eva Maria Cox, Frank Thomas Wunderlich, and Ari Waisman. "Constitutive AKT activation impairs B cell homeostasis and class switch recombination (P1443)." Journal of Immunology 190, no. 1_Supplement (2013): 174.4. http://dx.doi.org/10.4049/jimmunol.190.supp.174.4.

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Abstract The serine/threonine kinase AKT controls not only cellular metabolism, cell survival and proliferation but is also an important regulator for peripheral B cell maturation especially representing a critical check point in phases of proliferation and differentiation. In this study we investigated the role of constitutive AKT activation in B cell development and maturation through the use of a mouse strain allowing for the conditional expression of a N-terminally myristoylated AKT (ROSA-AKT-C) in cell types that express the Cre recombinase. The myristoylation signal recruits AKT-C to the

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Alvarez Narvaez, Sonsiray, and Susan Sanchez. "Exploring the Accessory Genome of Multidrug-Resistant Rhodococcus equi Clone 2287." Antibiotics 12, no. 11 (2023): 1631. http://dx.doi.org/10.3390/antibiotics12111631.

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Decades of antimicrobial overuse to treat respiratory disease in foals have promoted the emergence and spread of zoonotic multidrug-resistant (MDR) Rhodococcus equi worldwide. Three main R. equi MDR clonal populations—2287, G2106, and G2017—have been identified so far. However, only clones 2287 and G2016 have been isolated from sick animals, with clone 2287 being the main MDR R. equi recovered. The genetic mechanisms that make this MDR clone superior to the others at infecting foals are still unknown. Here, we performed a deep genetic characterization of the accessory genomes of 207 R. equi is

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Smith, Margaret C. M., William R. A. Brown, Andrew R. McEwan та Paul A. Rowley. "Site-specific recombination by φC31 integrase and other large serine recombinases". Biochemical Society Transactions 38, № 2 (2010): 388–94. http://dx.doi.org/10.1042/bst0380388.

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Most temperate phages encode an integrase for integration and excision of the prophage. Integrases belong either to the λ Int family of tyrosine recombinases or to a subgroup of the serine recombinases, the large serine recombinases. Integration by purified serine integrases occurs efficiently in vitro in the presence of their cognate (~50 bp) phage and host attachment sites, attP and attB respectively. Serine integrases require an accessory protein, Xis, to promote excision, a reaction in which the products of the integration reaction, attL and attR, recombine to regenerate attP and attB. Unl

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Gastineau, Romain, Gert Hansen, Michel Poulin, et al. "Haslea silbo, A Novel Cosmopolitan Species of Blue Diatoms." Biology 10, no. 4 (2021): 328. http://dx.doi.org/10.3390/biology10040328.

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Specimens of a new species of blue diatoms from the genus Haslea Simonsen were discovered in geographically distant sampling sites, first in the Canary Archipelago, then North Carolina, Gulf of Naples, the Croatian South Adriatic Sea, and Turkish coast of the Eastern Mediterranean Sea. An exhaustive characterization of these specimens, using a combined morphological and genomic approach led to the conclusion that they belong to a single new to science cosmopolitan species, Haslea silbo sp. nov. A preliminary characterization of its blue pigment shows similarities to marennine produced by Hasle

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Paolini-Bertrand, Marianne, Irène Rossitto-Borlat, Elsa Martins, and Oliver Hartley. "RB110 and RB157 antibodies recognize by ELISA specific phosphorylation patterns on CCR5 C-terminal peptides." Antibody Reports 3, no. 3 (2020): e155. http://dx.doi.org/10.24450/journals/abrep.2020.e155.

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Kersulyte, Dangeruta, Awdhesh Kalia, MaoJun Zhang, et al. "Sequence Organization and Insertion Specificity of the Novel Chimeric ISHp609 Transposable Element of Helicobacter pylori." Journal of Bacteriology 186, no. 22 (2004): 7521–28. http://dx.doi.org/10.1128/jb.186.22.7521-7528.2004.

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ABSTRACT Here we describe ISHp609 of Helicobacter pylori, a new member of the IS605 mobile element family that is novel and contains two genes whose functions are unknown, jhp960 and jhp961, in addition to homologs of two other H. pylori insertion sequence (IS) element genes, orfA, which encodes a putative serine recombinase-transposase, and orfB, whose homologs in other species are also often annotated as genes that encode transposases. The complete four-gene element was found in 10 to 40% of strains obtained from Africa, India, Europe, and the Americas but in only 1% of East Asian strains. S

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