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Artykuły w czasopismach na temat "Severe therapy-resistant asthma"

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Chung, Kian Fan. "Diagnosis and Management of Severe Asthma." Seminars in Respiratory and Critical Care Medicine 39, no. 01 (2018): 091–99. http://dx.doi.org/10.1055/s-0037-1607391.

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AbstractSevere therapy-resistant asthma has been defined as “asthma which requires treatment with high dose inhaled corticosteroids (ICSs) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming ‘uncontrolled’ or which remains ‘uncontrolled’ despite this therapy”. Patients who usually present with ‘difficult-to-treat asthma’ should first be assessed to determine whether he/she has asthma with the exclusion of other diagnoses and if so, whether the asthma can be classified as severe therapy-resistant. This necessitates an assessment of adherence to medications, co
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Porcaro, Federica, Nicola Ullmann, Annalisa Allegorico, Antonio Di Marco, and Renato Cutrera. "Difficult and Severe Asthma in Children." Children 7, no. 12 (2020): 286. http://dx.doi.org/10.3390/children7120286.

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Asthma is the most frequent chronic inflammatory disease of the lower airways affecting children, and it can still be considered a challenge for pediatricians. Although most asthmatic patients are symptom-free with standard treatments, a small percentage of them suffer from uncontrolled persistent asthma. In these children, a multidisciplinary systematic assessment, including comorbidities, treatment-related issues, environmental exposures, and psychosocial factors is needed. The identification of modifiable factors is important to differentiate children with difficult asthma from those with t
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Mandal, Anirban, and Puneet Kaur Sahi. "Is it Difficult to Treat Asthma in Children?" Journal of Medical Research and Innovation 1, no. 3 (2017): 23–30. http://dx.doi.org/10.15419/jmri.77.

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Asthma, the commonest chronic lung disease in childhood, is managed effectively with inhaled medications in most of the cases. But a subset of pediatric asthma patients continues to experience substantial morbidity even after higher doses of medications; they are referred to as problematic severe asthma. In many such cases, the apparent resistance to therapy is actually due to a number of remediable factors. These cases are called ‘difficult to treat asthma’. The physician dealing with a child with problematic severe asthma needs to follow a systematic step- wise approach to find any possible
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Mandal, A., and PK Shahi. "Is it difficult to treat asthma in children." Journal of Medical Research and Innovation 1, no. 3 (2017): 23–30. https://doi.org/10.5281/zenodo.825267.

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Asthma, the commonest chronic lung disease in childhood, is managed effectively with inhaled medications in most of the cases. But a subset of pediatric asthma patients continues to experience substantial morbidity even after higher doses of medications; they are referred to as problematic severe asthma. In many such cases, the apparent resistance to therapy is actually due to a number of remediable factors. These cases are called ‘difficult to treat asthma’. The physician dealing with a child with problematic severe asthma needs to follow a systematic step- wise approach to find any possible
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Kulikov, Ye S., L. M. Ogorodova, M. B. Freidin, I. V. Saltikova, I. A. Deyev, and P. A. Selivanova. "GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD." Bulletin of Siberian Medicine 13, no. 1 (2014): 47–55. http://dx.doi.org/10.20538/1682-0363-2014-1-47-55.

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Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: Ac
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Bush, Andrew. "Evaluating Severe Therapy-Resistant Asthma in Children: Diagnostic and Therapeutic Strategies." Medicina 60, no. 11 (2024): 1799. http://dx.doi.org/10.3390/medicina60111799.

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Introduction: Worldwide, asthma is the most common non-communicable respiratory disease and causes considerable morbidity and mortality. Most people with asthma can be treated effectively with low-dose medications if these are taken correctly and regularly. Around 10% of people with asthma have an uncontrolled form of the disease or can only achieve control with high-dose medications, incurring disproportionately high health care costs. Areas Covered: PubMed and personal archives were searched for relevant articles on the definition, management and pharmacotherapy of severe asthma. The WHO cla
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Chung, K. F. "Alternative treatments for difficult severe therapy-resistant asthma." Revue Française d'Allergologie et d'Immunologie Clinique 38, no. 9 (1998): 778–80. http://dx.doi.org/10.1016/s0335-7457(98)80192-5.

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Konradsen, J. R., B. Nordlund, C. Pedroletti, B. Dahlen, and G. Hedlin. "Identification Of Children With Severe Therapy Resistant Asthma." Journal of Allergy and Clinical Immunology 125, no. 2 (2010): AB70. http://dx.doi.org/10.1016/j.jaci.2009.12.276.

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CHOUDHURY, RAKIN, HELEN HASHEMI, and MARK MILLARD. "SEVERE ASTHMA CAUSED BY THERAPY-RESISTANT ASTHMATIC GRANULOMATOSIS." Chest 154, no. 4 (2018): 744A. http://dx.doi.org/10.1016/j.chest.2018.08.672.

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Fassakhov, R. S. "Severe eosinophilic asthma: therapeutic potential of Reslizumab." Medical Council, no. 15 (October 12, 2018): 70–75. http://dx.doi.org/10.21518/2079-701x-2018-15-70-75.

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The review discusses the problems associated with the treatment of patients with severe resistant to therapy asthma: prevalence, socio-economic burden, impact on quality of life. The phenotype of bronchial asthma with eosinophilic inflammation, frequency of occurrence, clinical features, and modern approaches to therapy are discussed in detail, including the use of a drug of monoclonal antibodies against interleukin 5-reslizumab.
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Rozprawy doktorskie na temat "Severe therapy-resistant asthma"

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Gupta, Atul. "Vitamin D and severe therapy resistant asthma in children." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40890.

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Background There is increasing evidence that low vitamin D levels are implicated in paediatric asthma Hypotheses Children with severe, therapy resistant (STRA) have low serum vitamin D levels which are associated with worse asthma control and airway pathology. In vitro, steroid responsiveness of peripheral blood mononuclear cells (PBMCs) from STRA is improved by vitamin D. Methods Serum 25-hydroxyvitamin D (25[OH]D3) was measured in 36 STRA, 26 mild/moderate asthmatics (MA) and 24 non-asthmatic controls, and related to asthma control and exacerbations. 22/36 children with STRA underwent bronch
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Adams, Alexandra. "The IL-17 family in paediatric severe therapy resistant asthma." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/54753.

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Paediatric asthma has traditionally been considered a T Helper 2 (TH2) cell mediated disease with the TH2 cytokines interleukin (IL)-4, IL-5 and IL-13 promoting eosinophilic airway inflammation, hyper-responsiveness and remodelling. In the majority of patients airway inflammation can be well controlled with low dose inhaled corticosteroids. There is however a small group in whom control is not achieved despite high dose corticosteroids, these children have severe therapy resistant asthma (STRA). Previous work in paediatric STRA showed a relative absence of the TH2 cytokines in the airways, but
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Części książek na temat "Severe therapy-resistant asthma"

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Adcock, Ian. "Chapter-09 Molecular and Immunological Basis for Severe Therapy-resistant Asthma." In Clinical Focus Series: Difficult Asthma. NULL, 2013. http://dx.doi.org/10.5005/jp/books/11898_9.

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Streszczenia konferencji na temat "Severe therapy-resistant asthma"

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Nagakumar, Prasad, Habib Ali, Priti Kenia, and Satish Rao. "Wet cough in paediatric severe therapy resistant asthma (STRA)." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa3355.

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Grime, Chris, Giorgia Garbato, Mark Rosenthal, Sejal Saglani, Louise Fleming, and Hui-Leng Tan. "Low prevalence of obstructive sleep apnoea in paediatric severe therapy resistant asthma." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa940.

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Kloosterman, Sanne F., Harm A. W. M. Tiddens, Joke L. Overweel, Johan C. De Jongste, and Hettie M. Janssens. "Small airways targeting of inhaled steroids for severe therapy resistant asthma in children." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa1283.

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Naime, S., K. Salka, E. Chorvinsky, M. A. Arroyo Morr, G. R. Nino, and D. K. Pillai. "Histone Deacetylase Activation in Bronchial Epithelium of Children with Severe Therapy Resistant Asthma." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3825.

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Irving, Samantha, Louise Fleming, Sejal Saglani, and Andrew Bush. "Scond may better discriminate severe therapy resistant asthma (STRA) from mild-moderate asthma than lung clearance index (LCI)." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa368.

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Cook, James, Andrew Bush, Sejal Saglani, and Louise Fleming. "Higher doses of inhaled steroid are associated with bacterial bronchitis in children with severe therapy resistant asthma (STRA)." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.oa4802.

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Konradsen, Jon, Anna James, Björn Nordlund, et al. "The Chitinase Like Protein YKL-40, Computerized Tomography And Airway Remodeling In Children With Severe Therapy Resistant Asthma." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3902.

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