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Artykuły w czasopismach na temat „Short-peptide Derivative”

Autor: Grafiati
Data publikacji: 7 września 2023
Data aktualizacji: 31 lipca 2025

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1

Sugiura, Takumi, Takurou Kanada, Daisuke Mori, et al. "Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative." Soft Matter 16, no. 4 (2020): 899–906. http://dx.doi.org/10.1039/c9sm01969c.

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2

Belyaeva, Veronika S., Yulia V. Stepenko, Igor I. Lyubimov, et al. "Non-hematopoietic erythropoietin-derived peptides for atheroprotection and treatment of cardiovascular diseases." Research Results in Pharmacology 6, no. 3 (2020): 75–86. http://dx.doi.org/10.3897/rrpharmacology.6.58891.

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Relevance: Cardiovascular diseases continue to be the leading cause of premature adult death. Lipid profile and atherogenesis: Dislipidaemia leads to subsequent lipid accumulation and migration of immunocompetent cells into the vessel intima. Macrophages accumulate cholesterol forming foam cells – the morphological substrate of atherosclerosis in its initial stage. Inflammation and atherogenesis: Pro-inflammatory factors provoke oxidative stress, vascular wall damage and foam cells formation. Endothelial and mitochondrial dysfunction in the development of atherosclerosis: Endothelial mitochond
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Belyaeva, Veronika S., Yulia V. Stepenko, Igor I. Lyubimov, et al. "Non-hematopoietic erythropoietin-derived peptides for atheroprotection and treatment of cardiovascular diseases." Research Results in Pharmacology 6, no. (3) (2020): 75–86. https://doi.org/10.3897/rrpharmacology.6.58891.

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Relevance: Cardiovascular diseases continue to be the leading cause of premature adult death. Lipid profile and atherogenesis: Dislipidaemia leads to subsequent lipid accumulation and migration of immunocompetent cells into the vessel intima. Macrophages accumulate cholesterol forming foam cells – the morphological substrate of atherosclerosis in its initial stage. Inflammation and atherogenesis: Pro-inflammatory factors provoke oxidative stress, vascular wall damage and foam cells formation. Endothelial and mitochondrial dysfunction in the development of atherosclerosis: Endothelial mitochond
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4

Mei, Jingjing, Xiaoli Zhang, Meifeng Zhu, Jianing Wang, Ling Wang та Lianyong Wang. "Barium-triggered β-sheet formation and hydrogelation of a short peptide derivative". RSC Adv. 4, № 3 (2014): 1193–96. http://dx.doi.org/10.1039/c3ra45023f.

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5

Radzishevsky, Inna S., Shahar Rotem, Fadia Zaknoon, Leonid Gaidukov, Arie Dagan, and Amram Mor. "Effects of Acyl versus Aminoacyl Conjugation on the Properties of Antimicrobial Peptides." Antimicrobial Agents and Chemotherapy 49, no. 6 (2005): 2412–20. http://dx.doi.org/10.1128/aac.49.6.2412-2420.2005.

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ABSTRACT To investigate the importance of increased hydrophobicity at the amino end of antimicrobial peptides, a dermaseptin derivative was used as a template for a systematic acylation study. Through a gradual increase of the acyl moiety chain length, hydrophobicity was monitored and further modulated by acyl conversion to aminoacyl. The chain lengths of the acyl derivatives correlated with a gradual increase in the peptide's global hydrophobicity and stabilization of its helical structure. The effect on cytolytic properties, however, fluctuated for different cells. Whereas acylation graduall
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6

Giannecchini, Simone, Armida Di Fenza, Anna Maria D'Ursi, Donatella Matteucci, Paolo Rovero, and Mauro Bendinelli. "Antiviral Activity and Conformational Features of an Octapeptide Derived from the Membrane-Proximal Ectodomain of the Feline Immunodeficiency Virus Transmembrane Glycoprotein." Journal of Virology 77, no. 6 (2003): 3724–33. http://dx.doi.org/10.1128/jvi.77.6.3724-3733.2003.

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ABSTRACT Feline immunodeficiency virus (FIV) provides a valuable animal model by which criteria for lentivirus control strategies can be tested. Previous studies have shown that a 20-mer synthetic peptide of the membrane-proximal ectodomain of FIV transmembrane glycoprotein, designated peptide 59, potently inhibited the growth of tissue culture-adapted FIV in feline fibroblastoid CrFK cells. In the present report we describe the potential of this peptide to inhibit the replication of primary FIV isolates in lymphoid cells. Because antiviral activity of peptide 59 was found to map to a short se
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7

Bai, Fengwei, Terrence Town, Deepti Pradhan, et al. "Antiviral Peptides Targeting the West Nile Virus Envelope Protein." Journal of Virology 81, no. 4 (2006): 2047–55. http://dx.doi.org/10.1128/jvi.01840-06.

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ABSTRACT West Nile virus (WNV) can cause fatal murine and human encephalitis. The viral envelope protein interacts with host cells. A murine brain cDNA phage display library was therefore probed with WNV envelope protein, resulting in the identification of several adherent peptides. Of these, peptide 1 prevented WNV infection in vitro with a 50% inhibition concentration of 67 μM and also inhibited infection of a related flavivirus, dengue virus. Peptide 9, a derivative of peptide 1, was a particularly potent inhibitor of WNV in vitro, with a 50% inhibition concentration of 2.6 μM. Moreover, mi
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8

Falla, T. J., and R. E. Hancock. "Improved activity of a synthetic indolicidin analog." Antimicrobial Agents and Chemotherapy 41, no. 4 (1997): 771–75. http://dx.doi.org/10.1128/aac.41.4.771.

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A novel cationic peptide, CP-11, based on the structure of the bovine neutrophil peptide indolicidin, was designed to increase the number of positively charged residues, maintain the short length (13 amino acids), and enhance the amphipathicity relative to those of indolicidin. CP-11, and especially its carboxymethylated derivative, CP-11C, demonstrated improved activity against gram-negative bacteria and Candida albicans, while it maintained the activity of indolicidin against staphylococci and demonstrated a reduced ability to lyse erythrocytes. In Escherichia coli, CP-11 was better able tha
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9

Praveen, Praveen, Chao Wang, Thomas N. G. Handley, et al. "A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity." International Journal of Molecular Sciences 24, no. 7 (2023): 6616. http://dx.doi.org/10.3390/ijms24076616.

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Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore, relaxin’s receptor, relaxin family peptide receptor 1 (RXFP1), is a potential target for the treatment of fibrosis and related disorders, including heart failure. H2 relaxin has a complex two-chain structure (A and B) and three disulfide bridges. Our laboratory has recently developed B7-33 peptide, a single-chain agonist based on the B-chain of H2 relaxin. However, the peptide B7-33 has a short circulation time in vitro in serum (t1/2 = ~6 min).
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10

Rosa, Elisabetta, Enrico Gallo, Teresa Sibillano, et al. "Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices." Gels 8, no. 12 (2022): 831. http://dx.doi.org/10.3390/gels8120831.

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Generated by a hierarchical and multiscale self-assembling phenomenon, peptide-based hydrogels (HGs) are soft materials useful for a variety of applications. Short and ultra-short peptides are intriguing building blocks for hydrogel fabrication. These matrices can also be obtained by mixing low-molecular-weight peptides with other chemical entities (e.g., polymers, other peptides). The combination of two or more constituents opens the door to the development of hybrid systems with tunable mechanical properties and unexpected biofunctionalities or morphologies. For this scope, the formulation,
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11

Barreto-Santamaría, Adriana, Zuly Jenny Rivera, Javier Eduardo García, et al. "Shorter Antibacterial Peptide Having High Selectivity for E. coli Membranes and Low Potential for Inducing Resistance." Microorganisms 8, no. 6 (2020): 867. http://dx.doi.org/10.3390/microorganisms8060867.

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Antimicrobial peptides (AMPs) have been recognised as a significant therapeutic option for mitigating resistant microbial infections. It has been found recently that Plasmodium falciparum-derived, 20 residue long, peptide 35409 had antibacterial and haemolytic activity, making it an AMP having reduced selectivity, and suggesting that it should be studied more extensively for obtaining new AMPs having activity solely targeting the bacterial membrane. Peptide 35409 was thus used as template for producing short synthetic peptides (<20 residues long) and evaluating their biological activity and
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12

Lyons, R. H., B. Q. Ferguson, and M. Rosenberg. "Pentapeptide nuclear localization signal in adenovirus E1a." Molecular and Cellular Biology 7, no. 7 (1987): 2451–56. http://dx.doi.org/10.1128/mcb.7.7.2451-2456.1987.

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The adenovirus E1a gene products are nuclear proteins important in transcriptional control of viral functions during infection. By producing normal E1a proteins and derivatives of E1a in bacteria and microinjecting these proteins into cultured cells, we were able to examine their ability to localize to the nucleus. We showed that a short peptide sequence at the carboxyl terminus of E1a is necessary for the rapid (30-min) nuclear localization of that protein. Additionally, we showed that just the last five amino acids of E1a are sufficient to direct nuclear accumulation of a heterologous protei
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13

Lyons, R. H., B. Q. Ferguson, and M. Rosenberg. "Pentapeptide nuclear localization signal in adenovirus E1a." Molecular and Cellular Biology 7, no. 7 (1987): 2451–56. http://dx.doi.org/10.1128/mcb.7.7.2451.

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The adenovirus E1a gene products are nuclear proteins important in transcriptional control of viral functions during infection. By producing normal E1a proteins and derivatives of E1a in bacteria and microinjecting these proteins into cultured cells, we were able to examine their ability to localize to the nucleus. We showed that a short peptide sequence at the carboxyl terminus of E1a is necessary for the rapid (30-min) nuclear localization of that protein. Additionally, we showed that just the last five amino acids of E1a are sufficient to direct nuclear accumulation of a heterologous protei
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14

Navalkissoor, Shaunak, and Ashley Grossman. "Targeted Alpha Particle Therapy for Neuroendocrine Tumours: The Next Generation of Peptide Receptor Radionuclide Therapy." Neuroendocrinology 108, no. 3 (2018): 256–64. http://dx.doi.org/10.1159/000494760.

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Neuroendocrine tumours (NETs) are being seen increasingly frequently, but to date only complete surgical resection is curative. However, among the various therapeutic options, peptide receptor radionuclide therapy, linking a radioactive moiety to an octreotide derivative, has been shown to be highly efficacious and a well-tolerated therapy, improving progression-free survival and probably overall survival. Nevertheless, the current radionuclides in use are beta particle emitters with non-optimal radiobiological properties. A new generation of alpha particle-emitting radionuclides is being deve
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15

Evans, AA, S. Khan, and ME Smith. "Evidence for a hormonal action of beta-endorphin to increase glucose uptake in resting and contracting skeletal muscle." Journal of Endocrinology 155, no. 2 (1997): 387–92. http://dx.doi.org/10.1677/joe.0.1550387.

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The uptake of 2-[3H]deoxyglucose, a non-metabolisable derivative of glucose, was studied in resting and contracting muscle. An isolated phrenic nerve/hemidiaphragm preparation of the mouse was used, and contractions of the muscle were elicited by electrical stimulation of the nerve. beta-Endorphin stimulated the uptake of 2-deoxyglucose in resting diaphragm muscle. The rate of uptake in the presence of the optimum concentration of beta-endorphin was similar to that in the presence of the optimum concentration of insulin over the short incubation period. beta-Endorphin also stimulated the uptak
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16

Santamaría, Carlos, Silda Larios, Steve Quirós, et al. "Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2." Antimicrobial Agents and Chemotherapy 49, no. 4 (2005): 1340–45. http://dx.doi.org/10.1128/aac.49.4.1340-1345.2005.

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ABSTRACT The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake Bothrops asper, have been shown to reproduce the bactericidal activity of the parent protein. They combine cationic and hydrophobic-aromatic amino acids, thus functionally resembling the antimicrobial peptides of innate defenses. This study evaluated the antimicrobial and antiendotoxic properties of a 13-mer derivative peptide of the C-terminal sequence from positions 115 to 129 of myotoxin II,
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17

Molotkov, Andrei, John W. Castrillon, Sreevidya Santha, et al. "The Radiolabeling of a Gly-Sar Dipeptide Derivative with Flourine-18 and Its Use as a Potential Peptide Transporter PET Imaging Agent." Molecules 25, no. 3 (2020): 643. http://dx.doi.org/10.3390/molecules25030643.

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We have developed a novel fluorine-18 radiotracer, dipeptide 1, radiolabeled in two steps from mesylate 3. The initial radiolabeling is achieved in a short reaction time (10 min) and purified through solid-phase extraction (SPE) with modest radiochemical yields (rcy = 10 ± 2%, n = 5) in excellent radiochemical purity (rcp > 99%, n = 5). The de-protection of the tert-butyloxycarbonyl (Boc) and trityl group was achieved with mild heating under acidic conditions to provide 18F-tagged dipeptide 1. Preliminary analysis of 18F-dipeptide 1 was performed to confirm uptake by peptide transporters (P
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18

Shan, Daming, Oliver W. Press, Theta T. Tsu, Martha S. Hayden, and Jeffrey A. Ledbetter. "Characterization of scFv-Ig Constructs Generated from the Anti-CD20 mAb 1F5 Using Linker Peptides of Varying Lengths." Journal of Immunology 162, no. 11 (1999): 6589–95. http://dx.doi.org/10.4049/jimmunol.162.11.6589.

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Abstract The heavy (VH) and light (VL) chain variable regions of the murine anti-human CD20 mAb 1F5 were cloned, and four single-chain Ab (scFv) molecules were constructed using linker peptides of variable lengths to join the VH and VL domains. Three constructs were engineered using linker peptides of 15, 10, and 5 aa residues consisting of (GGGGS)3, (GGGGS)2, and (GGGGS)1 sequences, respectively, whereas the fourth was prepared by joining the VH and VL domains directly. Each construct was fused to a derivative of human IgG1 (hinge plus CH2 plus CH3) to facilitate purification using staphyloco
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19

Saugar, José María, María Jesús Rodríguez-Hernández, Beatriz G. de la Torre, et al. "Activity of Cecropin A-Melittin Hybrid Peptides against Colistin-Resistant Clinical Strains of Acinetobacter baumannii: Molecular Basis for the Differential Mechanisms of Action." Antimicrobial Agents and Chemotherapy 50, no. 4 (2006): 1251–56. http://dx.doi.org/10.1128/aac.50.4.1251-1256.2006.

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ABSTRACT Acinetobacter baumannii has successfully developed resistance against all common antibiotics, including colistin (polymyxin E), the last universally active drug against this pathogen. The possible widespread distribution of colistin-resistant A. baumannii strains may create an alarming clinical situation. In a previous work, we reported differences in lethal mechanisms between polymyxin B (PXB) and the cecropin A-melittin (CA-M) hybrid peptide CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTGLPALIS-NH2) on colistin-susceptible strains (J. M. Saugar, T. Alarcón, S. López-Hernández, M. López-Bre
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20

Hinrichsen, M., M. Lenz, J. M. Edwards, et al. "A new method for post-translationally labeling proteins in live cells for fluorescence imaging and tracking." Protein Engineering, Design and Selection 30, no. 12 (2017): 771–80. http://dx.doi.org/10.1093/protein/gzx059.

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AbstractWe present a novel method to fluorescently label proteins, post-translationally, within live Saccharomycescerevisiae. The premise underlying this work is that fluorescent protein (FP) tags are less disruptive to normal processing and function when they are attached post-translationally, because target proteins are allowed to fold properly and reach their final subcellular location before being labeled. We accomplish this post-translational labeling by expressing the target protein fused to a short peptide tag (SpyTag), which is then covalently labeled in situ by controlled expression o
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21

Bojarska, Joanna, Martin Breza, Milan Remko, et al. "Structural and Biofunctional Insights into the Cyclo(Pro-Pro-Phe-Phe-) Scaffold from Experimental and In Silico Studies: Melanoma and Beyond." International Journal of Molecular Sciences 23, no. 13 (2022): 7173. http://dx.doi.org/10.3390/ijms23137173.

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Short peptides have great potential as safe and effective anticancer drug leads. Herein, the influence of short cyclic peptides containing the Pro-Pro-Phe-Phe sequence on patient-derived melanoma cells was investigated. Cyclic peptides such as cyclo(Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe-), called CLA, and cyclo(Pro-homoPro-β3homoPhe-Phe-), called P11, exert the cytotoxic and the cytostatic effects in melanoma cells, respectively. CLA was the most active peptide as it reduced the viability of melanoma cells to 50% of control at about 10 µM, whereas P11 at about 40 µM after 48 h incubation. Intere
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22

Giribaldi, Giuliana, Mauro Prato, Daniela Ulliers, et al. "Involvement of Inflammatory Chemokines in Survival of Human Monocytes Fed with Malarial Pigment." Infection and Immunity 78, no. 11 (2010): 4912–21. http://dx.doi.org/10.1128/iai.00455-10.

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ABSTRACT Hemozoin (HZ)-fed monocytes are exposed to strong oxidative stress, releasing large amounts of peroxidation derivatives with subsequent impairment of numerous functions and overproduction of proinflammatory cytokines. However, the histopathology at autopsy of tissues from patients with severe malaria showed abundant HZ in Kupffer cells and other tissue macrophages, suggesting that functional impairment and cytokine production are not accompanied by cell death. The aim of the present study was to clarify the role of HZ in cell survival, focusing on the qualitative and temporal expressi
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23

Antsiferov, Oleg V., Roman F. Cherevatenko, Mikhail V. Korokin, et al. "A new EPOR/CD131 heteroreceptor agonist EP-11-1: a neuroprotective effect in experimental traumatic brain injury." Research Results in Pharmacology 7, no. (4) (2021): 1–9. https://doi.org/10.3897/rrpharmacology.7.75301.

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Introduction: EP-11-1 (UEHLERALNSS) is a short-chain erythropoietin derivative without have erythropoietic activity. It was created by modifying a peptide mimicking the spatial structure of the erythropoietin a-helix B pHBSP. One of the promising directions of its administration is the correction of morphofunctional disorders that occur in traumatic brain injury (TBI). Materials and methods: The study was performed in 160 male Wistar rats, weighing 180–200 g.TBI was simulated using the drop-weight method. To assess the emerging morphofunctional disorders and a degree of their correction, we us
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24

Yasnopolsky, Yu V., A. V. Kokhanov, V. A. Zurnadzhyants, et al. "Test for the antimicrobial peptide lactoferricin in appendicitis and peritonitis." Astrakhan medical journal 19, no. 2 (2024): 111–19. http://dx.doi.org/10.17021/1992-6499-2024-2-111-119.

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The purpose of the study: was to compare the concentrations of bacterial infection indicators lactoferrin (LF) and lactoferricin (LFC) in the blood serum and peritoneal exudate of patients with destructive forms of acute appendicitis after laparoscopic and laparotomic appendectomy. The concentrations of LF protein and LFC peptide were studied in blood and peritoneal exudate samples of 45 patients with destructive forms of acute appendicitis of varying severity after laparoscopic or laparotomic appendectomy. When studying the levels of LF and LFC in patients with acute destructive appendicitis,
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25

Oliveira, Aline Cristina, Marcos Barrouin Melo, Daisy Motta-Santos, et al. "Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice." American Journal of Physiology-Heart and Circulatory Physiology 316, no. 1 (2019): H123—H133. http://dx.doi.org/10.1152/ajpheart.00075.2018.

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We have recently described a new peptide of the renin-angiotensin system, alamandine, a derivative of angiotensin-(1–7). Mas-related G protein-coupled receptor member D (MrgD) was identified as its receptor. Although similar cardioprotective effects of alamandine to those of angiotensin-(1–7) have been described, the significance of this peptide in heart function is still elusive. We aimed to evaluate the functional role of the alamandine receptor MrgD in the heart using MrgD-deficient mice. MrgD was localized in cardiomyocytes by immunofluorescence using confocal microscopy. High-resolution e
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26

Bingle, Wade H., Harry D. Kurtz Jr., and John Smit. "An ''all-purpose" cellulase reporter for gene fusion studies and application to the paracrystalline surface (S)-layer protein of Caulobacter crescentus." Canadian Journal of Microbiology 39, no. 1 (1993): 70–80. http://dx.doi.org/10.1139/m93-010.

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The secreted endoglucanase (CenA) from the Gram-positive bacterium Cellulomonas fimi and a deletion derivative (ΔCenA) lacking the N-terminal leader peptide of native CenA were used to explore the potential of ΔCenA as a reporter molecule in Caulobacter crescentus. Expression of cenA in C. crescentus yielded extracellular endoglucanase activity, suggesting that the N-terminal leader peptide of CenA could direct the enzyme to the periplasm where it subsequently leaked into the medium. In contrast, expression of ΔcenA yielded only cell-associated endoglucanase activity; this suggested that the e
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27

Pfister, Joachim, Roland Bata, Isabella Hubmann, et al. "Siderophore Scaffold as Carrier for Antifungal Peptides in Therapy of Aspergillus fumigatus Infections." Journal of Fungi 6, no. 4 (2020): 367. http://dx.doi.org/10.3390/jof6040367.

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Antifungal resistance of human fungal pathogens represents an increasing challenge in modern medicine. Short antimicrobial peptides (AMP) display a promising class of antifungals with a different mode of action, but lack target specificity and metabolic stability. In this study the hexapeptide PAF26 (Ac-dArg-dLys-dLys-dTrp-dPhe-dTrp-NH2) and the three amino acid long peptide NLF (H2N-Asn-Leu-dPhe-COOH) were coupled to diacetylfusarinine C (DAFC), a derivative of the siderophore triacetylfusarinine C (TAFC) of Aspergillus fumigatus, to achieve targeted delivery for treatment of invasive aspergi
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28

Todorov, Petar, Borislav Assenov, Dimo Angelov, Elena Dzhambazova, and Daniela Pechlivanova. "Behavioral Effects and Analgesic Profile of Hemoglobin-Derived Valorphin and Its Synthetic Analog in Rodents." Biomedicines 11, no. 10 (2023): 2783. http://dx.doi.org/10.3390/biomedicines11102783.

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Valorphin (V1) is a naturally occurring peptide derived from hemoglobin that has been found to have an affinity for opioid receptors and exhibits antinociceptive and anticonvulsant activity. Some of its synthetic analogs containing an aminophosphonate moiety show structure-dependent potent antinociceptive effects. This study aimed to reveal a detailed picture of the antinociceptive mechanisms and behavioral effects of V1 and its recently synthesized phosphopeptide analog V2p in rodents using a range of methods. The studied peptides significantly reduced acute (mean V1–9.0, V2p–5.8 vs. controls
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29

Arend, Sandra M., Anrik C. F. Engelhard, Gertjan Groot, et al. "Tuberculin Skin Testing Compared with T-Cell Responses to Mycobacterium tuberculosis-Specific and Nonspecific Antigens for Detection of Latent Infection in Persons with Recent Tuberculosis Contact." Clinical Diagnostic Laboratory Immunology 8, no. 6 (2001): 1089–96. http://dx.doi.org/10.1128/cdli.8.6.1089-1096.2001.

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ABSTRACT The tuberculin skin test (TST) is used for the identification of latent tuberculosis (TB) infection (LTBI) but lacks specificity inMycobacterium bovis BCG-vaccinated individuals, who constitute an increasing proportion of TB patients and their contacts from regions where TB is endemic. In previous studies, T-cell responses to ESAT-6 and CFP-10, M. tuberculosis-specific antigens that are absent from BCG, were sensitive and specific for detection of active TB. We studied 44 close contacts of a patient with smear-positive pulmonary TB and compared the standard screening procedure for LTB
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30

Antsiferov, Oleg V., Roman F. Cherevatenko, Mikhail V. Korokin, et al. "A new EPOR/CD131 heteroreceptor agonist EP-11-1: a neuroprotective effect in experimental traumatic brain injury." Research Results in Pharmacology 7, no. 4 (2021): 1–9. http://dx.doi.org/10.3897/rrpharmacology.7.75301.

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Introduction: EP-11-1 (UEHLERALNSS) is a short-chain erythropoietin derivative without have erythropoietic activity. It was created by modifying a peptide mimicking the spatial structure of the erythropoietin a-helix B pHBSP. One of the promising directions of its administration is the correction of morphofunctional disorders that occur in traumatic brain injury (TBI). Materials and methods: The study was performed in 160 male Wistar rats, weighing 180–200 g.TBI was simulated using the drop-weight method. To assess the emerging morphofunctional disorders and a degree of their correction, we us
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31

Gollan, Timothy J., and Michael R. Green. "Selective Targeting and Inducible Destruction of Human Cancer Cells by Retroviruses with Envelope Proteins Bearing Short Peptide Ligands." Journal of Virology 76, no. 7 (2002): 3564–69. http://dx.doi.org/10.1128/jvi.76.7.3564-3569.2002.

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ABSTRACT In the accompanying study, we show how retroviral tropism can be redirected by insertion of short peptide ligands at multiple locations in envelope. Here we use this approach to selectively target and destroy human cancer cells. Many cancer cells overexpress specific cell surface receptors. We have generated Moloney murine leukemia virus (MLV) envelope derivatives bearing short peptide ligands for gastrin-releasing protein (GRP) and human epidermal growth factor receptors. Pseudotyped viruses containing these chimeric envelope derivatives selectively transduce human cancer cell lines
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32

Moskowitz, Keith A., Josh Dee, Jason Barnidge, et al. "Hemostatic Properties of Infusible Trehalose-Stabilized Lyophilized Platelet Derivatives." Blood 104, no. 11 (2004): 834. http://dx.doi.org/10.1182/blood.v104.11.834.834.

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Abstract Availability of platelet concentrates for treatment of bleeding associated with thrombocytopenia, trauma, or drug-induced coagulopathies is problematic due to the short 5 day platelet storage time and because platelets require controlled shaking at ambient temperature in order to remain viable, a condition which augments bacterial growth. To address the platelet availability problem we expanded upon trehalose cryo-preservation technology to create a lyophilized hemostatic platelet derivative. Washed platelets were stabilized by accumulation of 5–10 mM intracellular trehalose via fluid
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33

Vakhrushev, Alexander V., Dmitry A. Gruzdev, Alexander M. Demin, Galina L. Levit, and Victor P. Krasnov. "Synthesis of Novel Carborane-Containing Derivatives of RGD Peptide." Molecules 28, no. 8 (2023): 3467. http://dx.doi.org/10.3390/molecules28083467.

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Short peptides containing the Arg-Gly-Asp (RGD) fragment can selectively bind to integrins on the surface of tumor cells and are attractive transport molecules for the targeted delivery of therapeutic and diagnostic agents to tumors (for example, glioblastoma). We have demonstrated the possibility of obtaining the N- and C-protected RGD peptide containing 3-amino-closo-carborane and a glutaric acid residue as a linker fragment. The resulting carboranyl derivatives of the protected RGD peptide are of interest as starting compounds in the synthesis of unprotected or selectively protected peptide
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34

Kaur, Harsimran, and Sangita Roy. "Designing aromatic N-cadherin mimetic short-peptide-based bioactive scaffolds for controlling cellular behaviour." Journal of Materials Chemistry B 9, no. 29 (2021): 5898–913. http://dx.doi.org/10.1039/d1tb00598g.

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35

Zelder, Felix. "Modified vitamin B12 derivatives with a peptide backbone for biomimetic studies and medicinal applications." Journal of Porphyrins and Phthalocyanines 22, no. 07 (2018): 535–41. http://dx.doi.org/10.1142/s108842461830001x.

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This short review highlights the author’s group research on modified vitamin B[Formula: see text] derivatives with a peptide backbone as (1) inhibitors of B[Formula: see text]-dependent enzymes and as (2) models of cofactor B[Formula: see text]-protein complexes.
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36

Kola, Satish Shamrao, Vishnu Nayak Badavath, Mohammad Idrees M. Siddique, Naqui Siddiqui, Chandrashekhar Devkate, and Syed Abrar Ahmed. "Microwave-assisted green synthesis and molecular docking study of some new 4-thiazolidinone derivatives as possible bioactive agents." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 03 (2024): 327. http://dx.doi.org/10.59467/ijhc.2024.34.327.

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We have developed an economical and environmentally friendly microwave-assisted efficient method for the synthesis of a series of new 4-oxo-thiazolidine derivatives (4a-d). The method involves microwave irradiated cyclocondensation reaction of Schiff bases (3a-d) and thioglycolic acid in drug master file (DMF). 4-oxo-thiazolidine derivatives (4a-d) was also synthe 4-Oxo-Thiazolidine derivatives were also synthesized by conventional heating procedures and consequence were Compared with Microwave assisted green method. The results suggest that microwave-assisted syntheses lead to higher yields w
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37

Ciura, Krzesimir, Natalia Ptaszyńska, Hanna Kapica, et al. "Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?" Antibiotics 10, no. 10 (2021): 1237. http://dx.doi.org/10.3390/antibiotics10101237.

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The emergence and spread of multiple drug-resistant bacteria strains caused the development of new antibiotics to be one of the most important challenges of medicinal chemistry. Despite many efforts, the commercial availability of peptide-based antimicrobials is still limited. The presented study aims to explain that immobilized artificial membrane chromatography can support the characterization of antimicrobial peptides. Consequently, the chromatographic experiments of three groups of related peptide substances: (i) short cationic lipopeptides, (ii) citropin analogs, and (iii) conjugates of c
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38

Lagadinou, Eleni D., Panagiotis G. Ziros, Olga A. Tsopra, et al. "c-Jun N-Terminal Kinase (JNK) Activation Failure Confers a New Mechanism of Anthracycline Resistance in Acute Myeloid Leukemia (AML)." Blood 110, no. 11 (2007): 2377. http://dx.doi.org/10.1182/blood.v110.11.2377.2377.

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Abstract Chemotherapy resistance remains a major challenge in the treatment of acute myeloid leukemia (AML). Besides the P-glycoprotein efflux of chemotherapeutics, additional cellular factors may contribute to drug resistance in AML. c- Jun N-terminal Kinase (JNK) is a protein kinase activated after exposure of cells to chemotherapeutic agents. Recently, studies in solid tumours have associated chemoresistance with failure of cancer cells to activate JNK. We asked whether drug resistance in AML is also attributed to intrinsic failure of the AML blasts to activate JNK. In vitro treatment of U9
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39

Gureev, Vladimir V., Mikhail V. Korokin, Ivan V. Golubev, Mikhail V. Pokrovsky, Adelaida V. Polyanskaya та Dmitriy B. Kuzmin. "Correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B". Курский научно-практический вестник «Человек и его здоровье», № 2 (червень 2020): 42–49. http://dx.doi.org/10.21626/vestnik/2020-2/06.

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Objective. The aim of the study is to investigate the correction of functional disorders in ADMA-like preeclampsia with derivatives of the peptide imitating erythropoietin α-helix B. Materials and methods. The study was performed in 120 white female Wistar rats weighing 250-300 g. ADMA-like preeclampsia was used as experimental preeclampsia. To assess the effectiveness of the pharmacological agents used, blood pressure, microcirculation in the placenta, and proteinuria were recorded, the content of final NO metabolites in the blood plasma was determined, and the coefficient of endothelial dysf
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40

Tereshchenkov, Andrey G., Zimfira Z. Khairullina, Inna A. Volynkina, et al. "Triphenylphosphonium Analogs of Short Peptide Related to Bactenecin 7 and Oncocin 112 as Antimicrobial Agents." Pharmaceutics 16, no. 1 (2024): 148. http://dx.doi.org/10.3390/pharmaceutics16010148.

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Antimicrobial peptides (AMPs) have recently attracted attention as promising antibacterial agents capable of acting against resistant bacterial strains. In this work, an approach was applied, consisting of the conjugation of a peptide related to the sequences of bactenecin 7 (Bac7) and oncocin (Onc112) with the alkyl(triphenyl)phosphonium (alkyl-TPP) fragment in order to improve the properties of the AMP and introduce new ones, expand the spectrum of antimicrobial activity, and reduce the inhibitory effect on the eukaryotic translation process. Triphenylphosphonium (TPP) derivatives of a decap
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41

Gollan, Timothy J., and Michael R. Green. "Redirecting Retroviral Tropism by Insertion of Short, Nondisruptive Peptide Ligands into Envelope." Journal of Virology 76, no. 7 (2002): 3558–63. http://dx.doi.org/10.1128/jvi.76.7.3558-3563.2002.

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ABSTRACT A potentially powerful approach for in vivo gene delivery is to target retrovirus to specific cells through interactions between cell surface receptors and appropriately modified viral envelope proteins. Previously, relatively large (>100 residues) protein ligands to cell surface receptors have been inserted at or near the N terminus of retroviral envelope proteins. Although viral tropism could be altered, the chimeric envelope proteins lacked full activity, and coexpression of wild-type envelope was required for production of transducing virus. Here we analyze more than 40 derivat
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42

Tivari, Sunil R., Siddhant V. Kokate, Enrique Delgado-Alvarado, et al. "A novel series of dipeptide derivatives containing indole-3-carboxylic acid conjugates as potential antimicrobial agents: the design, solid phase peptide synthesis, in vitro biological evaluation, and molecular docking study." RSC Advances 13, no. 35 (2023): 24250–63. http://dx.doi.org/10.1039/d3ra04100j.

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A new library of peptide-heterocycle hybrids consisting of an indole-3-carboxylic acid constituent conjugated with short dipeptide motifs was designed and synthesized by using the solid phase peptide synthesis methodology.
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43

Fu, Y. X., M. Vollmer, H. Kalataradi, et al. "Structural requirements for peptides that stimulate a subset of gamma delta T cells." Journal of Immunology 152, no. 4 (1994): 1578–88. http://dx.doi.org/10.4049/jimmunol.152.4.1578.

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Abstract Hybridomas representing the V gamma 1-positive subset of murine gamma delta T cells secrete lymphokines in response to synthetic peptides representing a short segment of the mycobacterial 60-kDa heat shock protein (HSP-60). Here we show the TCR dependency of this response by transfection of productively rearranged TCR genes derived from an HSP-60 reactive gamma delta T cell hybridoma. We also have defined structural requirements for the stimulatory peptide. The smallest HSP-60 peptide capable of stimulating these hybridomas is seven amino acids long, representing positions 181-187, an
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44

Chattopadhyay, Shital Kumar, Subhankar Ghosh, and Suman Sil. "Cross metathesis-mediated synthesis of hydroxamic acid derivatives." Beilstein Journal of Organic Chemistry 14 (December 17, 2018): 3070–75. http://dx.doi.org/10.3762/bjoc.14.285.

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An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N-benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs’ second generation catalyst within short time and in good yields (57–85%) with a range of substrates. Subsequent hydrogenation of each of the CM products delivers the title compounds in moderate to very good yield (70–89%). An important demonstration of the protocol is the preparation of the unusual amino acid component of the bioactive cyclic peptide Chap-31.
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45

Tomizaki, Kin-ya, Tomomi Iori, Hideyasu Fukushima, Yasuhiro Nakabayashi, Yoshiki Matsumoto та Takahito Imai. "Tandem-Homodimer of a β-Sheet-Forming Short Peptide Inhibits Random-to-β Structural Transition of Its Original Monomer". Processes 8, № 11 (2020): 1421. http://dx.doi.org/10.3390/pr8111421.

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There is an increasing interest in designing fibrillogenesis modulators for treating amyloid β (Aβ)-peptide-associated diseases. The use of Aβ fragment peptides and their derivatives, as well as nonpeptidyl natural products, is one promising approach to prevent Aβ fibrillation. In this study, we demonstrate that tandem-homodimers (TDs) of a β-sheet-forming short peptide in which the amino acid sequence is duplicated in series and joined via an amino alkanoic acid linker of different chain lengths, preventing the random-to-β structural transition of the original monomer. Ape5-TD, containing 5-a
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46

Pouzar, Vladimír, та Ivan Černý. "Preparation of (17E)-3β-Hydroxyandrost-5-en-17-one (O-Carboxymethyl)oxime Derivatives with Short Peptide Chain". Collection of Czechoslovak Chemical Communications 59, № 9 (1994): 2042–56. http://dx.doi.org/10.1135/cccc19942042.

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17-(O-Carboxymethyl)oxime (CMO) derivatives of 3β-acetoxy-, 3β-methoxymethoxy-, 3β-hydroxyandrost-5-en-17-one, and of -androst-4-ene-3,17-dione (IV - VI, XXIX) were prepared. Methods for the attachment of amino acids to the CMO group and for the peptide chain elongation were tested. The mixed anhydride method was used for linking the first amino acid unit (Gly, βAla, or Gly-Gly dipeptide), further units were added by the N-hydroxysuccinimide method. Compounds with one to four amino acids were prepared. This concept is suitable for the preparation of haptens with variable bridge length for the
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47

Karamać, M., E. Sendrejová, A. Kosińska, and D. Urminská. "Presence of ferulic acid in wheat glutenin fraction and its enzymatic hydrolysates – a short report." Czech Journal of Food Sciences 25, No. 6 (2008): 359–64. http://dx.doi.org/10.17221/751-cjfs.

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Three protein fractions: albumin-globulin, gliadin, and glutenin were extracted from wheat grains. Enzymatic hydrolysates were obtained from each fraction using trypsin, protease from <I>Bacillus subtilis</I> and Subtilisin Carlsberg. Ferulic acid was detected neither in albumin-globulin and gliadin fractions nor in their hydrolysates. The RP-HPLC and SE-HPLC chromatograms of the glutenin fraction and its hydrolysates revealed the presence of peaks originated from ferulic acid and ferulic acid derivative/complex. The content of ferulic acid in the glutenin fraction was 1.12 mg/g. D
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48

Kang, Yubin, Jian Wu, Xiaobei Wang, et al. "Development of Thioredoxin Monothiol Derivatives for Mitigating Radiation Induced Hematopoietic Injury." Blood 142, Supplement 1 (2023): 3639. http://dx.doi.org/10.1182/blood-2023-185355.

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Hematopoietic stem cells (HSCs) are among the most sensitive cells to radiation injury and contribute to many of the manifestations of acute radiation syndrome. There is an unmet need for effective agents that can be used to rescue radiation injury and enhance HSC recovery especially when administered post-irradiation. We previously identified the stress-protective human thioredoxin-1 protein (TRX) as a novel molecule for enhancing HSC recovery in mouse models of radiation injury. Treatment of lethally irradiated mice with recombinant TRX 24 hours after irradiation increased survival by 45%. H
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49

Albada, H. Bauke, Alina-Iulia Chiriac, Michaela Wenzel, et al. "Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups." Beilstein Journal of Organic Chemistry 8 (October 15, 2012): 1753–64. http://dx.doi.org/10.3762/bjoc.8.200.

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A series of small synthetic arginine and tryptophan containing peptides was prepared and analyzed for their antibacterial activity. The effect of N-terminal substitution with metallocenoyl groups such as ferrocene (FcCO) and ruthenocene (RcCO) was investigated. Antibacterial activity in different media, growth inhibition, and killing kinetics of the most active peptides were determined. The toxicity of selected derivatives was determined against erythrocytes and three human cancer cell lines. It was shown that the replacement of an N-terminal arginine residue with a metallocenoyl moiety modula
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50

Navon-Venezia, Shiri, Rina Feder, Leonid Gaidukov, Yehuda Carmeli, and Amram Mor. "Antibacterial Properties of Dermaseptin S4 Derivatives with In Vivo Activity." Antimicrobial Agents and Chemotherapy 46, no. 3 (2002): 689–94. http://dx.doi.org/10.1128/aac.46.3.689-694.2002.

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ABSTRACT Derivatives of the cytotoxic peptide dermaseptin S4 have recently emerged as potential antimicrobial agents. Here, we report on the antibacterial properties of three derivatives with improved toxicity profiles: a 28-residues K4K20-S4 and two shorter versions, K4-S4(1-16) and K4-S4(1-13). The range of MICs of K4K20-S4 against clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli were, respectively, 1 to 4, 1 to 4, and 1 to 16 μg/ml. MICs of the short derivatives were rather similar or two to fourfold higher. Each of the three peptides was rapidly bact
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