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Rozprawy doktorskie na temat „Signalling”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Schelfaut, Roselien. "Integrin Signalling." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6265.

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<p>Integrins are receptors presented on most cells. By binding ligand they can generate signalling pathways inside the cell. Those pathways are a linkage to proteins in the cytosol. It is known that tumor cells can survive and proliferate in the absence of a solid support while normal cells need to be bound to ligand. To understand why tumour cells act that way, we first have to know how ligand-binding to integrins affect the cell. This research field includes studies on activation of proteins by integrins and the following protein-protein interactions.</p><p>The part of the research that I di

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2

Demuth, Dirk Geoffrey. "Cannabinoid signalling." Thesis, University of Hertfordshire, 2004. http://hdl.handle.net/2299/14229.

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The general aim of the study was to investigate the signalling pathways utilised by cannabinoids. Cannabinoid CB1 receptor stimulation in DDT, MF-2 smooth muscle cells induces a rise in [Ca2], which is dependent on extracellular Cat' and modulated by thapsigargin-sensitive stores and MAP kinase suggesting capacitative Ca2+ entry (CCE). Non-capacitative calcium entry (NCCE) stimulated by arachidonic acid (AA) partly mediates histamine Hl receptor-evoked increases in [Ca2+]; in DDTI MF-2 cells. In the current study both Ca 2+ entry mechanisms and a possible link between MAP kinase activation and

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3

Potter, Timothy James. "Transmembrane signalling." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275041.

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4

O'Byrne, Declan. "CD28 and associated signalling elements of T lymphocyte signalling." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266468.

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5

Shivdasani, Anish Anil. "Hedgehog signalling, TGF-Î² signalling and spermatogenesis in Drosophila melanogaster." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408836.

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6

Jordan, Lindsay. "Signalling Towards IRES." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19946.

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XIAP and Bcl-xL are critical anti-apoptotic molecules that directly inhibit caspases and block mitochondrial membrane permeabilization, respectively. In addition to preventing apoptosis, both XIAP and Bcl-xL can be generated by cap-independent translation via the utilization of an IRES in the 5'-UTR of their mRNAs. In recent years it has been shown that activation of S6K2 induces the translational upregulation of these two apoptotic regulators. Here I have determined that activation of S6K2 enhances IRES-mediated translation of XIAP and Bcl-xL by inducing the degradation of PDCD4, which I have

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7

Anderson, Ian Paul. "Met receptor signalling." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526784.

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8

Clynes, David Alexander. "Signalling to chromatin." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496840.

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9

Samuels, Michael L. "Yeast stress signalling." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368116.

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10

Is'Harc, Hayaatun. "JAK/STAT signalling." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272414.

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11

Stephens, Sebastien. "Novel Osteoclast Signalling." Thesis, Griffith University, 2010. http://hdl.handle.net/10072/365823.

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When you say osteoporosis, people think of their grandma’s brittle bones, but scientists think of the osteoclast. When you say cancer, people think of death, but before this, many succumb to the osteoclast. The fact is all these things are true yet it is even truer to say that each disease in fact also has more of the other – osteoporosis and death, and cancer and brittle bones. However, the commonality is undeniably the osteoclast. Scratching the surface of the osteoclast reveals that it is the basis of a diversity of bone-related disorders yet the osteoclast itself is, even given the large a

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12

Halilagic, Aida. "Retinoid signalling in forebrain development and COUP-TF and retinoid signalling." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399574.

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13

Altosaar, Katrin. "Dimer-dependent allosteric modulation within GPCR signalling complexes can influence signalling diversity." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114353.

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G protein-coupled receptors (GPCRs) comprise the largest group of cell surface receptors, translating environmental signals into cellular responses via cognate G protein partners. Contrary to our initial understanding, most GPCRs do not function in living cells as monomers, but most likely dimers, or even larger arrays of receptors. Standard drug design approaches rely on the notion that drugs binding the two receptors in a given dimer likely function independently of one another. However, this view has been challenged by recent work showing that ligand binding at both receptors can modulate d

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14

Bryon, K. H. R. "Multiple dopamine signalling pathways antagonize RHO-1 signalling in the nervous system." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419852/.

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Alterations in RhoA (RHO-1) signalling cause neuronal signalling defects in both mammals and C. elegans. In the case of C. elegans, exaggerated RHO-1 signalling in cholinergic neurons (nRHO-1*) has numerous effects that include increased release of acetylcholine (ACh) and exaggerated body curvature during locomotion. A suppressor screen identified the mutation, nz99, that suppresses nRHO-1* exaggerated curvature, but not increased ACh release. Non-neuronal defects caused by heat-shock, expression of RHO-1* (sterility, death, tail-swelling and protruding vulva) were not suppressed, suggesting t

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15

Li, Xiaolei. "Quadgate forward-signalling pipelines." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442597.

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16

Melford, Steven K. "Calcium signalling in megakaryocytes." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364104.

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17

Rebocho, Ana Paula da Mota Torres. "Cellular signalling by Araf." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531334.

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18

McVeigh, P. "Neuropeptide signalling in nematodes." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411747.

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19

Lindqvist, Susanne. "Colonic crypt calcium signalling." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327537.

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20

Sun, Yan. "Cannabinoids and PPARa signalling." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431260.

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21

Greig, Aina Vibeke Hiller. "Purinergic signalling in skin." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407987.

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22

Brickell, Laura. "Wound signalling Arabidopsis thaliana." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286054.

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23

Jai-Yoon, Sul. "Calcium signalling in astrocytes." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391921.

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24

Sarafimidis, Ioannis. "Polyketide signalling in Dictyostelium." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615971.

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25

Lau, C. I. "Hedgehog signalling in haematopoiesis." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1428443/.

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The Hedgehog (Hh) family proteins and their signalling pathway are key mediators of, and important in, many mammalian developmental processes. Malfunction of the Hh signalling pathway contributes to developmental disorders and birth defects. This project aims to investigate the role of the Hh signalling pathway in murine haematopoiesis. In our study, we found that Dhh plays a negative regulatory role in normal erythropoiesis and under stress conditions. However, it is not required for regulating erythropoiesis in the fetal liver during embryo development. In contrast, analysis of conditional d

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26

Benford, Heather Elizabeth. "Signalling in hypothalamic tanycytes." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/62112/.

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Hypothalamic tanycytes are a specialised type of glial cell found lining the 3rd ventricle. They possess a cell body that contacts the cerebrospinal fluid (CSF) and a single long process that projects into the hypothalamic parenchyma, some of which are known to extend into the Arcuate nucleus (ARC) and Ventromedial nucleus (VMN), two key hypothalamic regions involved in control of energy homeostasis. Owing to their unique position, it has been hypothesised that hypothalamic tanycytes may be able to detect nutrient related signals in the CSF and influence the neurons of the ARC and VMN leading

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27

Gagliardi, M. "Endocytosis and wingless signalling." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1353109/.

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Wingless (Drosophila Wnt-1) is secreted glycoprotein that triggers an evolutionary conserved signal transduction pathway. The role of endocytosis in Wnt/Wingless signaling is not clearly understood and highly debated. In my thesis I explore the role that endocytosis/endocytic trafficking has on Wingless signalling activation and termination. In the canonical pathway Wingless binds to a member of the Frizzled family of seven-pass transmembrane receptor (Frizzled1 or Frizzled2) and to Arrow. Formation of this trimeric complex leads to the inactivation of the Armadillo degradation complex and tra

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28

Bond, Alistair. "Purinergic signalling in osteoblasts." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/11293/.

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ATP is now well established as an extracellular signalling molecule and has been shown to play a role in many different tissues including bone. ATP acting on P2 receptors has been reported to cause an increase in osteoblast proliferation, apoptosis, IL-6 production, AA release and a decrease in bone mineralization. It has also been shown in vivo, by using KO mice, that ATP can cause both an anabolic and catabolic response depending on the P2 receptor involved, with P2Y2 KO mice showing an increased bone formation whilst P2X7 mice have a decrease in the periosteal bone formation. ATP is release

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29

Káradóttir, Raghildur Póra. "Neurotransmitter signalling to oligodendrocytes." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1446463/.

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Neurotransmitter signalling to neurons and glial cells plays a key role in brain development, information processing and pathological processes. This thesis focuses on neurotransmitter signalling to oligodendrocytes, the glial cells which provide myelin to speed the propagation of action potentials along neuronal axons. In cerebellar and corpus callosal slices, I used patch-clamping and immunocytochemistry to examine the properties of precursor, immature and mature oligodendrocytes, characterizing their morphology and basic electrical properties, their response to glutamate, GABA and other neu

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30

Hiskens, Richard Andrew. "The interaction of activator of G protein signalling 1 (AGS1) with signalling components." Thesis, University of Warwick, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422078.

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31

Brodin, Greger. "Smad7 in TGF-β Signalling". Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1949.

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<p>Members of the transforming growth factor-β (TGF-β) superfamily of growth and differentiation factors regulate a vast array of biological functions in the adult, and are of great importance in governing cell fate determination and patterning in the developing embryo. The TGF-β signal is propagated intracellularly by Smad proteins resulting in transcriptional responses. Smad6 and Smad7 are inhibitory Smads known to downregulate the TGF-β signal and thereby possibly modulating the biological response. This thesis describes a functional analysis of the inhibitory Smad7 from an <i>in vitro </i>

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32

Cargill, James. "Multitone signalling on telephone lines." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5543.

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33

Law, Robert. "PDE3A signalling in blood platelets." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:13761.

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Cyclic 3’, 5’ adenosine monophosphate (cAMP) signalling downstream of prostacyclin (PGI₂) is a key inhibitory pathway in blood platelets. This pathway is dynamically regulated by phosphodiesterase 3A (PDE3A), which hydrolyses cAMP into metabolically inactive AMP. Although PDE3A is an established drug target in anti-platelet therapies, the molecular mechanisms that underlie its function in platelets remain unclear. Therefore, the major aim of this study was to further explore PDE3A signalling in human platelets. Using a combination of cell fractionation and immunoblotting we identified two PDE3

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34

Tadros, Amir. "Novel pathways in microvascular signalling." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29504.

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The regulation of microvascular survival impacts both developmental remodelling of the vasculature, and various pathologies. The aim of this thesis was to examine the role of a recently identified A20 binding inhibitor of NF-kB, a zinc finger protein termed ABIN-2 in endothelial protection. More specifically, looking at its effects on inflammation and apoptosis in endothelia both at the cellular level and in vivo. The involvement of ABIN-2 in the Tie2 receptor pathway was also examined. Tie2 is an endothelial receptor essential for blood vessel formation and promotes endothelial survival. A tr

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35

Kaplan, Andrew Daniel. "Purinoceptor signalling in skeletal cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq28500.pdf.

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36

Day, Jonathan Robert Stewart. "Therapeutic inhibition of thrombin signalling." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434321.

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37

Haines, Nicola. "Mutational analysis of hedgehog signalling." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365823.

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38

Saltmarsh, Esther Joy. "Calcium signalling in neutrophil behaviour." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55796/.

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Neutrophils are at the front line of defence in humans against attack by invading pathogens. They undergo complex behaviours, many of which are controlled by changes in the concentration of cytosolic free calcium ions (Ca2+). However, the control and mechanisms of these behaviours are still the subject of much research and debate. Ca2+ is known to be important in many different cell systems. There are a plethora of Ca2+ signalling events in the "Ca2+ toolkit", but not all cells have each element. It is not fully understood elements of the toolkit that neutrophils employ to make up their well-

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39

Ludlow, Melanie Joanna. "Purinergic signalling in dictyostelium discoideum." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/7450.

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The identification of five predicted proteins (dP2XA-E) with homology to vertebrate P2X receptors in Dictyostelium discoideum proved a unique opportunity to explore purinergic receptor function in a simple unicellular eukaryote from outside the animal kingdom. dP2XE was shown to be expressed as a trimer and trafficked to the cell surface in Xenopus oocytes. However, no currents were detected to extracellularly applied ligands. This lack of function was potentially due to inaccurate post-translational modifications since dP2XE expressed in oocytes and D. discoideum displayed different molecular

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40

Allen, John Cronin. "Neutrophil signalling via Fcγ receptors". Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494099.

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It has previously been shown that removal or blocking of the neutrophil receptor, FcyRIIIb (CD16b) completely prevented the ability of neutrophils to secrete reactive oxidants and granule enzymes in response to soluble immune complexes (SIC), but had no effect on the phagocytosis and killing of serum-opsonised Staphylococcus aureus. As soluble immune complexes are the major neutrophil activating factors in the synovial fluids of patients with rheumatoid arthritis, the aim of this work is to determine the intracellular signalling pathways regulated by FcYRIIIb to understand, in more detail, neu

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41

Brennan, Damian Frederick. "Structural studies of MAPK signalling." Thesis, Institute of Cancer Research (University Of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511162.

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42

Lee, Sue Chin. "Spatial signalling of phosphatidic acid." Thesis, University of Strathclyde, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510804.

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43

Dawson, M. A. F. "JAK-STAT signalling at chromatin." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598423.

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The aim of my work was to explore the possibility that the mammalian JAK2 signalling pathway influences the structure and function of chromatin. I have demonstrated that JAK2 is present in the nucleus of both human haematopoietic cell lines and primary cells. My results suggest that JAK2 functions as a histone tyrosine kinase and phosphorylates histone H3 at tyrosine-41 (H3Y41). This novel histone modification, the first described tyrosine phosphorylation on any of the non-variant histones, regulates the binding of heterochromatin protein 1-alpha (HP1α) at a new binding site on chromatin. HP1α

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44

McGouran, Joanna. "Probing sugar-plant-soil signalling." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526091.

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45

Moon, Alice E. "Immune signalling in insect cells." Thesis, Kingston University, 2009. http://eprints.kingston.ac.uk/20407/.

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Immune responses in insects include components and mechanisms that are highly evolutionarily conserved. In addition to providing insight into the insects themselves, knowledge of the conserved mechanisms involved in insect immunity can offer valuable insight that is broadly relevant to a wide variety of other species. Three aspects of insect immune cell signalling have been studied here. Cell signalling responses have been investigated in two insect cell lines following treatment with double stranded (ds) RNA, a common intermediate of viral replication. It has been established that both cell l

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46

Zhou, Zhigang. "TNF signalling in endothelial cells." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435077.

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Pleiotropic cytokine tumour necrosis factor a (TNF) is the archetypal member of a large super-family of ligands and associated receptors. Through its two surface presenting receptors, TNFRI and TNFR2, TNF can elicit responses such as differentiation, proliferation, and apoptosis, depending on several factors such as microenvironment, cell cycle, and cell type. Recent evidence indicated that TNF can be up-regulated in endothelial cells (EC) upon their stimulation and plays an important role in regulating EC responses which have been implicated in several cardiovascular diseases, such as heart f

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47

Iessi, Elisabetta. "TRAIL signalling regulation by ezrin." Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00695336.

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Background and Aim: TRAIL has sparked a growing interest in oncology due to its ability to selectively trigger cancer cell death while sparing normal cells. The Fas/actin association through ezrin, a member of the ERM protein family, has been reported to regulate early steps of Fas-mediated apoptosis. In this project, we addressed the role of ezrin regarding TRAIL-induced cell death in B lymphoma cell lines, or adherent cancer cell lines (HeLa WT, HCT116, SW480). Methods: Molecular and biochemical approaches were employed to study the relevance of ezrin and its phosphorylation status in TRAIL

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48

Chen, Daliang. "Cell signalling in Paracoccidioides brasiliensis." Thesis, Durham University, 2006. http://etheses.dur.ac.uk/2655/.

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Paracocidioides brasiliensis (P. brasiliensis or Pb) is the etiological agent of paracocidioidomycosis which is the most prevalent systemic mycosis in South America. About 60% of the clinical cases are found concentrated in Brazil and the disease is a major threat for the public health there, p. brasiliensis is a dimorphic fungus because it undergoes a morphological switching from a mycelium to yeast form after shifting the temperature from 26 c to 37 c. Similar morphological changes have been implicated to be important in the pathogenicity of other dimorphic fungi and they appear to be under

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49

Schweinzer, Paul Gernot. "Three essays on signalling games." Thesis, Birkbeck (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442064.

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Woodroffe, P. J. "Mathematical modelling of cell signalling." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416886.

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