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Artykuły w czasopismach na temat „Simons' control mechanisms”

Autor: Grafiati

Data publikacji: 9 listopada 2024

Data aktualizacji: 31 lipca 2025

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Pandithasekara, Dasuni Nirmani, Erabaddage Ayoma Gayathri Sumanasiri, and Áron Perényi. "Exploring the Impact of Sustainability Control Systems on Employees’ Green Creativity: The Mediating Role of Psychological Empowerment and Sustainability Learning Capabilities." Sustainability 15, no. 6 (2023): 4806. http://dx.doi.org/10.3390/su15064806.

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This paper investigates how sustainability control systems (SCSs) drive employees’ green creativity (EGC) with the purpose of assisting organisations in the Sri Lankan manufacturing sector to improve their environmental sustainability performance. Managers and staff of manufacturing firms often lack awareness of environmental issues, which leads to unsustainable strategies. EGC has been identified as an important resource for devising sustainable strategies. SCSs drive employee behaviour and support EGC by fostering a creative workplace. Utilising Simons’ Levers of Controls (LoC) framework, a

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Yuan, Yanru, and Nian Lu. "Strategic Use of Management Control Systems in Navigating Organizational Change: A Conceptual Framework." Frontiers in Business, Economics and Management 19, no. 3 (2025): 42–45. https://doi.org/10.54097/fhrevf56.

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Organizational change is an inevitable response to dynamic environments, competitive pressures, and technological advancement. However, executing strategic change effectively remains a persistent challenge for managers. In this context, Management Control Systems (MCS) play a crucial role not merely in monitoring performance, but in guiding and enabling organizations through uncertainty and transformation. This paper explores how MCS—particularly when used strategically—can support organizations in aligning employee behavior, managing risk, and fostering innovation during periods of change. Dr

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Zhao, Liang, Yang Bai, Jie Ma, and Yonghui Wang. "Local Control Mechanisms of Implicit and Explicit Conflicts." Experimental Psychology 62, no. 3 (2015): 153–60. http://dx.doi.org/10.1027/1618-3169/a000281.

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Congruency sequence effects are observed when the congruency effects following incongruent trials are smaller than those following congruent trials. It is typically assumed that such flexible adjustments are evidence of cognitively controlled dynamic modulations. The present study investigated whether cognitive control acts locally or globally when implicit and explicit conflicts exist simultaneously within a system. The implicit SNARC task and explicit Simon task were combined in a single task. The results showed that congruency effects of one type (e.g., SNARC effect) were only smaller follo

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BLUMENFELD, HENRIKE K., and VIORICA MARIAN. "Cognitive control in bilinguals: Advantages in Stimulus–Stimulus inhibition." Bilingualism: Language and Cognition 17, no. 3 (2013): 610–29. http://dx.doi.org/10.1017/s1366728913000564.

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Bilinguals have been shown to outperform monolinguals at suppressing task-irrelevant information and on overall speed during cognitive control tasks. Here, monolinguals’ and bilinguals’ performance was compared on two nonlinguistic tasks: a Stroop task (with perceptualStimulus–Stimulus conflictamong stimulus features) and a Simon task (withStimulus–Response conflict). Across two experiments testing bilinguals with different language profiles, bilinguals showed more efficient Stroop than Simon performance, relative to monolinguals, who showed fewer differences across the two tasks. Findings sug

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Soutschek, Alexander, Hermann J. Müller, and Torsten Schubert. "Conflict-Specific Effects of Accessory Stimuli on Cognitive Control in the Stroop Task and the Simon Task." Experimental Psychology 60, no. 2 (2013): 140–48. http://dx.doi.org/10.1027/1618-3169/a000181.

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Both the Stroop and the Simon paradigms are often used in research on cognitive control, however, there is evidence that dissociable control processes are involved in these tasks: While conflicts in the Stroop task may be resolved mainly by enhanced task-relevant stimulus processing, conflicts in the Simon task may be resolved rather by suppressing the influence of task-irrelevant information on response selection. In the present study, we show that these control mechanisms interact in different ways with the presentation of accessory stimuli. Accessory stimuli do not affect cognitive control

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Salzer, Yael, Daniela Aisenberg, Tal Oron-Gilad, and Avishai Henik. "In Touch With the Simon Effect *The first two authors contributed equally." Experimental Psychology 61, no. 3 (2014): 165–79. http://dx.doi.org/10.1027/1618-3169/a000236.

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Cognitive control has been extensively studied using the auditory and visual modalities. In the current study, a tactile version of the Simon task was created in order to test control mechanisms in a modality that was less studied, to provide comparative and new information. A significant Simon effect – reaction time gap between congruent (i.e., stimulus and response in the same relative location) and incongruent (i.e., stimulus and response in opposite locations) stimuli – provided grounds to further examine both general and tactile-specific aspects of cognitive control in three experiments.

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Struys, Esli, Ghazal Mohades, Peggy Bosch, and Maurits van den Noort. "Cognitive Control in Bilingual Children." Swiss Journal of Psychology 74, no. 2 (2015): 65–73. http://dx.doi.org/10.1024/1421-0185/a000152.

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Studies comparing the cognitive control of bilingual and monolingual speakers are inconclusive about the nature and underlying mechanisms of differences in language-related processing. In the present study, in order to disentangle the impact of second-language onset age of acquisition and bilingualism on cognitive control, we compared a group of bilingual Dutch/French children who had started acquisition of both languages at birth (simultaneous bilingual group) to a group of children who had started acquisition of their second language at the age of 3 years (early bilingual group). Both groups

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Suarez, Isabel, Franck Vidal, Boris Burle, and Laurence Casini. "A Dual-Task Paradigm to Study the Interference Reduction in the Simon Task." Experimental Psychology 62, no. 2 (2015): 75–88. http://dx.doi.org/10.1027/1618-3169/a000275.

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Analyzing RT distributions in the Simon task reveals that congruency effects decrease for the longest RTs. Four experiments were carried out to examine whether this decrease of the congruency effect with response speed was under a top-down control or due to bottom-up mechanisms. We specifically manipulated the availability of attentional resources by requiring participants to perform a Simon task concurrently to different secondary tasks. RT distribution analysis (in particular delta functions) was performed under both single-task and dual-task conditions. Results show that the reduction of th

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Mowery, Cody, Jacob Freimer, Jennifer Umhoefer, et al. "CRISPRi and KO screens reveal integrated cis- and trans-regulation of the CD28, CTLA4, and ICOS locus in primary human T cells." Journal of Immunology 208, no. 1_Supplement (2022): 56.17. http://dx.doi.org/10.4049/jimmunol.208.supp.56.17.

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Abstract Costimulation is essential for complete T cell activation, requiring the coordinated expression of various surface proteins including those encoded by CD28 family members CD28, CTLA4, and ICOS. Interestingly, these three genes lie adjacently in a topologically-associating domain (TAD) and are believed to have arisen through duplications of CD28, though they have evolved opposing functions and exhibit expression differences across cell states and T cell subsets. We hypothesized that distinct cis- and trans-regulatory circuits emerged to uniquely govern the expression of each gene. Ther

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Massaro, Maurizio, Andrea Moro, and Mike Lucas. "Approcci formali e informali al controllo negli innovation network. La relazione tra Leve del Controllo e Fattori della Fiducia." MANAGEMENT CONTROL, no. 1 (May 2012): 27–54. http://dx.doi.org/10.3280/maco2012-001003.

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In recent years, there has been a significant increase in inter-organisational collaboration resulting in the emergence of hybrid organisational forms. This has led to recognition that management control can no longer be confined to the boundaries of a single organisation. Management control systems (MCS) must encompass networks of organisations. Inter-organisational relationships require both formal and informal controls. The latter are essentially mechanisms for encouraging self regulation. Significant among these mechanisms is trust. In inter-organisational collaborations high levels of tru

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Forstmann, Birte U., Wery P. M. van den Wildenberg, and K. Richard Ridderinkhof. "Neural Mechanisms, Temporal Dynamics, and Individual Differences in Interference Control." Journal of Cognitive Neuroscience 20, no. 10 (2008): 1854–65. http://dx.doi.org/10.1162/jocn.2008.20122.

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Functional magnetic resonance imaging (fMRI) methods may help in understanding processes of response capture and response inhibition in conflict tasks, such as the Simon task. However, data-driven approaches thus far have not yielded consistent insights into these processes. Here, a theory-driven approach is introduced that capitalizes on individual differences in the processes of central interest. Based on the so-called activation-suppression model, specific behavioral parameters for each individual derived from reaction time (RT) distribution analysis were computed and entered into model-bas

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Lafargue, Audrey M., Hailun Wang, Sivarajan T. Chettiar, et al. "Abstract 2968: TWIST1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of TWIST1." Cancer Research 84, no. 6_Supplement (2024): 2968. http://dx.doi.org/10.1158/1538-7445.am2024-2968.

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Abstract Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription factor TWIST1 is strongly associated with metastatic cancers and treatment resistance. Additionally, TWIST1 can upregulate O-GlcNAcylation which (1) is required to suppress fail-safe programs such as oncogene (KRasG12D)-induced senescence (OIS) to accelerate tumorigenesis in primary NSCLC tumors, and (2) is a potential modulator of DNA repair/radiation response. To decipher the domains and transcriptional targets required for tumorigenic

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Correa, Ángel, Paola Cappucci, Anna C. Nobre, and Juan Lupiáñez. "The Two Sides of Temporal Orienting." Experimental Psychology 57, no. 2 (2010): 142–48. http://dx.doi.org/10.1027/1618-3169/a000018.

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Would it be helpful to inform a driver about when a conflicting traffic situation is going to occur? We tested whether temporal orienting of attention could enhance executive control to select among conflicting stimuli and responses. Temporal orienting was induced by presenting explicit cues predicting the most probable interval for target onset, which could be short (400 ms) or long (1,300 ms). Executive control was measured both by flanker and Simon tasks involving conflict between incompatible responses and by the spatial Stroop task involving conflict between perceptual stimulus features.

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Shih, Pei-Chun, África Pérez-Santiago, Daniel Peña, Daniel Wazne, and Santiago Román. "Jumping to Conclusions: Mechanisms of Cognitive Control in Decision-Making Under Uncertainty." Behavioral Sciences 15, no. 2 (2025): 226. https://doi.org/10.3390/bs15020226.

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Cognitive control encompasses mental processes that regulate thoughts and actions to achieve specific goals. It is essential in decision-making, facilitating attention management, impulse inhibition, and adaptation to new information—skills critical for rational choices, particularly under uncertainty. In jumping to conclusions (JTC), where individuals make premature decisions based on limited evidence, cognitive control deficits are often implicated. Cognitive stability helps maintain focus and resist distractions but may lead to premature conclusions if excessive. In contrast, cognitive flex

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Wylie, Scott A., K. Richard Ridderinkhof, Theodore R. Bashore, and Wery P. M. van den Wildenberg. "The Effect of Parkinson's Disease on the Dynamics of On-line and Proactive Cognitive Control during Action Selection." Journal of Cognitive Neuroscience 22, no. 9 (2010): 2058–73. http://dx.doi.org/10.1162/jocn.2009.21326.

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Processing irrelevant visual information sometimes activates incorrect response impulses. The engagement of cognitive control mechanisms to suppress these impulses and make proactive adjustments to reduce the future impact of incorrect impulses may rely on the integrity of frontal–basal ganglia circuitry. Using a Simon task, we investigated the effects of basal ganglia dysfunction produced by Parkinson's disease (PD) on both on-line (within-trial) and proactive (between-trial) control efforts to reduce interference produced by the activation of an incorrect response. As a novel feature, we app

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Boutris, Panagiotis, Jessica Rees, Brodie Bevan, and Cristina Izura. "Bilingualism and cognitive reserve: It’s a matter of top-down or bottom-up process." Yearbook of the Poznan Linguistic Meeting 6, no. 1 (2020): 113–58. http://dx.doi.org/10.14746/yplm.2020.6.5.

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Cognitive performance declines with age following different trajectories. The cognitive trade-off, however, between age and cognitive reserve is still not clear. In addition, bilingualism has been thought to play a role in delaying cognitive decline by affecting cognitive control outside the scope of language. However, the effect has been unreliably reproduced and without exploring sufficiently the differences between cognitive functions that govern language control. In the current study 112 adults varying in age, level of bilingualism and cognitive reserve, completed a modified version of the

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Ueno, Fumihiko, Ippei Takahashi, Hisashi Ohseto, et al. "Deep-embedded clustering by relevant scales and genome-wide association study in autism." PLOS One 20, no. 5 (2025): e0322698. https://doi.org/10.1371/journal.pone.0322698.

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Autism spectrum disorder (ASD) presents with heterogeneous phenotypic and genetic characteristics. Despite investigation into the molecular mechanisms underlying ASD, its etiology remains elusive. In our previous investigation within the Simons Simplex Collection (SSC), we noted increased signals through a genome-wide association study (GWAS) by clustering patients with ASD and reducing the sample size. This study seeks to validate our previous study in a different population, the Simons Foundation Powering Autism Research for Knowledge (SPARK) population, while probing further into the geneti

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LILL, PHILIPP A., ANDREAS WALD, and RONALD GLEICH. "AGILITY AND THE ROLE OF PROJECT — INTERNAL CONTROL SYSTEMS FOR INNOVATION PROJECT PERFORMANCE." International Journal of Innovation Management 24, no. 07 (2019): 2050064. http://dx.doi.org/10.1142/s1363919620500644.

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As a reaction to the rapidly changing environment, organisations increasingly use agile project management (APM) methods to develop innovation. The associated process changes necessitate the adaption of organisational structures and control systems. This study draws on Simon’s Levers-of-Control framework (LOC) to explore the impact of different control levers on innovation project performance. Based on a survey of 316 project managers and product owners, the results suggest that the use of interactive project control systems and project-internal belief systems has a positive impact on the inno

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Grisetto, Fanny, Pierre Le Denmat, Yvonne N. Delevoye-Turrell, et al. "Imbalanced weighting of proactive and reactive control as a marker of risk-taking propensity." PLOS ONE 18, no. 1 (2023): e0277246. http://dx.doi.org/10.1371/journal.pone.0277246.

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According to the dual mechanisms of control (DMC), reactive and proactive control are involved in adjusting behaviors when maladapted to the environment. However, both contextual and inter-individual factors increase the weight of one control mechanism over the other, by influencing their cognitive costs. According to one of the DMC postulates, limited reactive control capacities should be counterbalanced by greater proactive control to ensure control efficiency. Moreover, as the flexible weighting between reactive and proactive control is key for adaptive behaviors, we expected that maladapti

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Vissers, Marlies E., K. Richard Ridderinkhof, Michael X. Cohen, and Heleen A. Slagter. "Oscillatory Mechanisms of Response Conflict Elicited by Color and Motion Direction: An Individual Differences Approach." Journal of Cognitive Neuroscience 30, no. 4 (2018): 468–81. http://dx.doi.org/10.1162/jocn_a_01222.

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Goal-directed behavior requires control over automatic behavior, for example, when goal-irrelevant information from the environment captures an inappropriate response and conflicts with the correct, goal-relevant action. Neural oscillations in the theta band (∼6 Hz) measured at midfrontal electrodes are thought to form an important substrate of the detection and subsequent resolution of response conflict. Here, we examined the extent to which response conflict and associated theta-band activity depend on the visual stimulus feature dimension that triggers the conflict. We used a feature-based

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Lemaire, Patrick, and Thomas Hinault. "Age-Related Differences in Sequential Modulations of Poorer-Strategy Effects." Experimental Psychology 61, no. 4 (2014): 253–62. http://dx.doi.org/10.1027/1618-3169/a000244.

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To determine how younger and older adults modulate execution of strategies across successive trials, we asked participants to accomplish a computational estimation task (i.e., provide approximate products to two-digit multiplication problems like 38 × 74). For each problem, they were cued to execute a better versus a poorer strategy. Their performance revealed sequential modulations of poorer-strategy effects (i.e., longer solution times and larger error rates when asked to execute a poorer than a better strategy). That is, poorer-strategy effects were smaller on current problems after using a

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Klostermann, André. "Does the Simon Effect Interfere with the Synergy Between Perception and Action?" Perceptual and Motor Skills 128, no. 4 (2021): 1765–84. http://dx.doi.org/10.1177/00315125211022917.

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Research suggests that – particularly – the execution of precision-demanding far-aiming tasks necessitates an optimal coupling between perception and action. In this regard, the duration of the last fixation before initiating movement – i.e., the Quiet Eye (QE) – has been functionally related to subsequent motor performance. In the current study, we investigated potential mechanisms of QE by applying the Simon paradigm – i.e., cognitive interferences evoked by stimulus-effect incompatibilities over response selection. To this end, we had participants throw balls as precisely as possible, eithe

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Ficarella, Stefania C., Andrea Desantis, Alexandre Zénon, and Boris Burle. "Preparing to React: A Behavioral Study on the Interplay between Proactive and Reactive Action Inhibition." Brain Sciences 11, no. 6 (2021): 680. http://dx.doi.org/10.3390/brainsci11060680.

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Motor preparation, based on one’s goals and expectations, allows for prompt reactions to stimulations from the environment. Proactive and reactive inhibitory mechanisms modulate this preparation and interact to allow a flexible control of responses. In this study, we investigate these two control mechanisms with an ad hoc cued Go/NoGo Simon paradigm in a within-subjects design, and by measuring subliminal motor activities through electromyographic recordings. Go cues instructed participants to prepare a response and wait for target onset to execute it (Go target) or inhibit it (NoGo target). P

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Ivy, Julia. "Capabilities of Entrepreneurial Ventures that Successfully Navigate Regime Change: A Research Agenda." International Journal of Business and Management Research 8, no. 3 (2020): 73–83. http://dx.doi.org/10.37391/ijbmr.080303.

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The study provides a framework and research agenda for investigating factors that contribute to the sustainability and growth of entrepreneurial ventures operating in environments of regime change. The suggested framework builds on Herbert Simon’s [1] science of design, as later extended to concepts of entrepreneurship as creation [2] and effectuation [3], in order to describe the nature of entrepreneurial actions in an environment of regime change. The framework integrates theory on organizational capabilities [4] to locate mechanisms behind entrepreneurs’ successful efforts to equip their ve

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Ali, Nilufa, David W. Green, Ferath Kherif, Joseph T. Devlin, and Cathy J. Price. "The Role of the Left Head of Caudate in Suppressing Irrelevant Words." Journal of Cognitive Neuroscience 22, no. 10 (2010): 2369–86. http://dx.doi.org/10.1162/jocn.2009.21352.

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Suppressing irrelevant words is essential to successful speech production and is expected to involve general control mechanisms that reduce interference from task-unrelated processing. To investigate the neural mechanisms that suppress visual word interference, we used fMRI and a Stroop task, using a block design with an event-related analysis. Participants indicated with a finger press whether a visual stimulus was colored pink or blue. The stimulus was either the written word “BLUE,” the written word “PINK,” or a string of four Xs, with word interference introduced when the meaning of the wo

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Fang, Liang, Dimin Li, and Paul A. Welling. "Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms." American Journal of Physiology-Renal Physiology 299, no. 6 (2010): F1359—F1364. http://dx.doi.org/10.1152/ajprenal.00257.2010.

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The renal outer medullary K+ (ROMK) channel plays a critical role in renal sodium handling. Recent genome sequencing efforts in the Framingham Heart Study offspring cohort (Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, and Lifton RP. Nat Genet 40: 592–599, 2008) recently revealed an association between suspected loss-of-function polymorphisms in the ROMK channel and resistance to hypertension, suggesting that ROMK activity may also be a determinant of blood pressure control in the general population. Here we examine whether these sequence variants do, i

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Fernandez Cruz, Ana Lucia, Chien-Ming Chen, Ryan Sanford, et al. "Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men." PLOS ONE 16, no. 7 (2021): e0243670. http://dx.doi.org/10.1371/journal.pone.0243670.

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Objective This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection. Methods Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and an inhibitory control (Simon) task while time-locked high-density EEG was acquired; 66 had usable EEG data from one or both tasks; structural MRI was available for 43. We investigated relationships between task-evoked EEG responses, cognitive ability and immunocompromise. We also explored the structural correlates of these EEG markers in

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Hoppe, Katharina, Edmund Wascher, and Kristina Küper. "Feature Overlap and Relevance Determine Sequential Modulations in the Simon Task." Journal of Psychophysiology 34, no. 2 (2020): 81–98. http://dx.doi.org/10.1027/0269-8803/a000239.

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Abstract. Subjects usually respond faster and more accurate in trials in which the response location corresponds to a task-irrelevant stimulus location compared to when not. Previous research has shown, that this so-called Simon effect is reduced after non-corresponding compared to after corresponding trials. As of now it is yet unclear what exact mechanisms drive such sequential modulations. One theory assumes a conflict adaptation mechanism that decreases the influence of incongruent information after non-corresponding trials via increased cognitive control. However, other authors claim that

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Abrasowicz, Gabriela. "Discourse on Corporeality and the Logic of Control in the Works of Contemporary post-Yugoslav Women Playwrights." AM Journal of Art and Media Studies, no. 18 (April 15, 2019): 51. http://dx.doi.org/10.25038/am.v0i18.296.

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The issue of corporeality is one of the dominant motifs in contemporary women’s playwriting in the countries formed after the collapse of Yugoslavia. At the turn of the 20th and 21st centuries women’s bodies function as a specific open register in their works, where real-life content is included. The body is also an instrument which detects the meanings of social actions and interactions. According to the authors – mainly from Serbia, Croatia, Bosnia and Herzegovina, and Montenegro – the body becomes a constantly-transforming palimpsestic, multi-layered body-text which delivers information abo

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Pinheiro, Pedro, and Goran Putnik. "Organizational efficiency prospects for management in Industry 4.0." FME Transactions 49, no. 4 (2021): 773–83. http://dx.doi.org/10.5937/fme2104773p.

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Industry 4.0 emerges as a tool to help organizations manage. Often identified with the Internet of Things and Cyber-Physical Systems, Industry 4.0 appears as a solution to many of the difficulties plaguing manufacturing. The history of management theories, e.g. by Taylor, Fayol, or Simon, shows that deterministic solutions do not ensure the permanent success of organizations. In manufacturing, the economy overlaps the technological, social, environmental, and cultural dimensions that influence organizations. This paper assesses the possible benefits for the efficiency of the organizations resu

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Haque, Mohammad Mozammel, Shihab Uddin Ahmad, and Md Shakhawat Hossain. "Anamika’s Deprivation of Higher Education in Fasting, Feasting: A Feminist Critique of Female Autonomy and Social Oppression." International Journal of English Literature and Social Sciences 10, no. 4 (2025): 001–7. https://doi.org/10.22161/ijels.104.1.

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This paper critically analyzes the character of Anamika in Anita Desai’s Fasting, Feasting (1999) as a representation of the systemic denial of female autonomy, particularly in relation to higher education. Employing feminist frameworks from Simone de Beauvoir and Gayatri Chakravorty Spivak, the study explores how patriarchal control within the domestic sphere suppresses women’s intellectual potential and silences their agency. De Beauvoir’s concept of woman as the “Other” reveals the structural mechanisms that confine women to roles of immanence, while Spivak’s theory of subalternity frames A

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Umbu Henggu, Krisman, and Yopi Nurdiansyah. "Review dari Metabolisme Karbohidrat, Lipid, Protein, dan Asam Nukleat." QUIMICA: Jurnal Kimia Sains dan Terapan 3, no. 2 (2022): 9–17. http://dx.doi.org/10.33059/jq.v3i2.5688.

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Artikel review ini mengulas tentang prinsip dan proses metabolisme karbohidrat, lipid, protein dan asam nukeat pada organisme. Telaah pustaka yang disajikan dalam review ini bersumber pada jurnal ilmiah maupun buku terakreditasi yang relevan. Lintasan metabolisme karbohidrat, lipid, protein, asam nukleat terdiri atas tiga bentuk lintasan yakni katabolik, anabolik dan amfibolik. Lintasan tersebut umumnya terjadi pada mitokondria melalui siklus Krebs. Katabolisme protein, karbohidrat dan lemak dapat menjadi derivat asam amino, glukosa, gliserol dan asam lemak yang mampu dikonversi menjadi energi

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Woodard, Tyler, Viju Gupta, Simona Miceska, Bisiayo Fashemi, Wendy Zhang, and Dineo Khabele. "Abstract 795: Entinostat restores responsiveness to Olaparib in ID8 TP53 null and ID8 TP53 null/BRCA2 null mouse ovarian cancer cell lines." Cancer Research 82, no. 12_Supplement (2022): 795. http://dx.doi.org/10.1158/1538-7445.am2022-795.

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Abstract Poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors (PARPi) reduce disease progression in patients diagnosed with ovarian cancer. The anticancer effects of PARPi are most effective in tumors with BRCA mutations and homologous recombination (HR) deficiency (HRD). One mechanism of PARPi resistance is through restoration of HR repair. Our group has shown that entinostat (an HDACi) potentiates the effects of olaparib (a PARPi). The objective of this study was to investigate mechanisms of intrinsic PARPi resistance by studying the combination of entinostat and olaparib in HR pr

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Anderson, Jack. "Doping, sport and the law: time for repeal of prohibition?" International Journal of Law in Context 9, no. 2 (2013): 135–59. http://dx.doi.org/10.1017/s1744552313000050.

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AbstractThis article concerns the legal issues that surround the prohibition of doping in sport. The current policy on the use of performance enhancing drugs (PEDs) in sport is underpinned by both a paternalistic desire to protect athletes' health and the long-term integrity or ‘spirit’ of sport. The policy is put into administrative effect globally by the World Anti-Doping Agency (WADA), which provides the regulatory and legal framework through which the vast majority of international sports federations harmonise their anti-doping programmes. On outlining briefly both the broad administrative

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Calderon-Aparicio, Ali Jose, and Nicole L. Simone. "Abstract 4677: Combating radioresistance in lung cancer: S6K1 signaling as a therapeutic target through metabolic modulation." Cancer Research 85, no. 8_Supplement_1 (2025): 4677. https://doi.org/10.1158/1538-7445.am2025-4677.

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Abstract Background: Locally advanced non-small cell lung cancer (NSCLC) is treated with a combination of chemotherapy, immunotherapy, and radiation but is unfortunately still associated with poor cancer survival. Improving radiation efficacy is essential to enhance tumor control and reduce resistance, ultimately improving outcomes for patients. Metabolic reprogramming could play a key role in this by targeting cancer cell metabolism to increase sensitivity to radiation and reduce tumor growth. S6K1 has emerged as a metabolic regulator that promotes chemo and radio-resistance in several cancer

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Daniya, Mumtaz &. Jasmeen Kaur. "The Subjugation of Muslim Women as 'other' in Qaisra Shahraz's The Holy Woman." Literary Druid Volume 4, Issue 3 (2022): 12–17. https://doi.org/10.5281/zenodo.7076106.

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<em>The research probes the anguish of Muslim women through the character Zarri Bano from “The Holy Woman” which represents the socially constructed norms under the name of religion to supply assured directions to women. The study scrutinizes the patriarchal norms that govern cultural and religious practices to maintain male hegemony in Pakistani society. It also depicts the role of women and their objectification in the society of Pakistan. The research examines how women’s stature is confined to the role of mother and daughter in Pakistani society, however, when they d

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Hobbs, Gabriela, Cansu Cimen Bozkus, Erin Moshier, et al. "PD-1 inhibition in advanced myeloproliferative neoplasms." Blood Advances 5, no. 23 (2021): 5086–97. http://dx.doi.org/10.1182/bloodadvances.2021005491.

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Abstract Myelofibrosis (MF) is a clonal stem cell neoplasm characterized by abnormal JAK-STAT signaling, chronic inflammation, cytopenias, and risk of transformation to acute leukemia. Despite improvements in the therapeutic options for patients with MF, allogeneic hematopoietic stem cell transplantation remains the only curative treatment. We previously demonstrated multiple immunosuppressive mechanisms in patients with MF, including increased expression of programmed cell death protein 1 (PD-1) on T cells compared with healthy controls. Therefore, we conducted a multicenter, open-label, phas

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Simon, M. Celeste. "Abstract IA017: Impact of oxygen and nutrient availability on sarcoma tumor neighborhood." Clinical Cancer Research 28, no. 18_Supplement (2022): IA017. http://dx.doi.org/10.1158/1557-3265.sarcomas22-ia017.

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Abstract Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous biochemical reactions, making it essential for most species on Earth. Accordingly, decreased oxygen concentration (hypoxia) is a major stressor that generally subverts life of aerobic species and is a prominent feature of pathological states encountered in bacterial infection, inflammation, wounds, cardiovascular defects and cancer. Therefore, key adaptive mechanisms to cope with hypoxia have evolved in mammals. Systemically, these adaptations include increased ventilation, cardiac output, blood ves

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O'Reilly, Eileen Mary, Maeve Aine Lowery, Kenneth H. Yu, et al. "Randomized phase II study of gemcitabine (G), cisplatin (C) with or without veliparib (V) (arms A, B) and a phase II single-arm study of single-agent veliparib (arm C) in patients with BRCA or PALB2-mutated pancreas adenocarcinoma (PC)." Journal of Clinical Oncology 31, no. 15_suppl (2013): TPS4144. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.tps4144.

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TPS4144 Background: Germline mutations in BRCA1, 2 predispose to PC (Lal, G. Cancer Res, 2000). 5-8% PC have BRCA 1,2 mutations; higher in Ashkenazi Jewish (10-15%). Pre-clinical data demonstrates that platinums and poly-ADP ribose polymerase inhibitors (PARPi) have activity in BRCA-mutated PC models. Early clinical data supporting (Lowery, M. Oncol, 2011). We are evaluating the role of platinum agents and PARPi, veliparib (ABT-888), in BRCA or PALB2-mutated PC. Methods: Arm A, B: Includes non-randomized phase to optimize V dose combined with G, C (Arm A). Subsequently randomized phase II stud

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Prabhakar, S., and A. K. Goel. "Learning about novel operating environments: Designing by adaptive modelling." Artificial Intelligence for Engineering Design, Analysis and Manufacturing 10, no. 2 (1996): 151–56. http://dx.doi.org/10.1017/s0890060400001438.

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According to Simon (1983), machine learning is a process that improves the performance of an intelligent system. The performance task of a design system is to arrive at a structural description of a device given its functional description. Machine learning can occur, to improve the performance of the design system, in a number of ways. The learning can make the process of arriving at a known structure to function mapping faster, either by improving the control strategy or by learning new world knowledge needed for the structure to function mapping. It can also improve the performance of the de

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Danesi, Marcel. "The Language of Power: Casini and Bancheri's In-Depth Analysis of Italian in Immigration and Global Contexts." Italica 99, no. 2 (2022): 282–98. http://dx.doi.org/10.5406/23256672.99.2.08.

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Abstract This review article looks at a groundbreaking book in sociolinguistics by Simone Casini and Salvatore Bancheri, What Is the Language of Power? Theoretical Reflections on Italian, Italiese and Other Languages, which focuses on the forms and uses of Italian in immigrant communities, as well as the role of the Italian language in the global village in which we now reside. Based on research conducted on the kind of Italian that takes shape in immigrant communities, called “Italiese,” one of the main insights that can be gleaned from this penetrating book is that the language that emerges

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Einstein, David Johnson, Atish Dipankar Choudhury, Philip James Saylor, et al. "A phase II study of onvansertib (PCM-075) in combination with abiraterone and prednisone in patients with metastatic castration-resistant prostate cancer." Journal of Clinical Oncology 37, no. 7_suppl (2019): TPS336. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.tps336.

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TPS336 Background: Metastatic castration-resistant prostate cancer (mCRPC) remains a leading cause of cancer-related deaths worldwide. Although abiraterone (abi) in either the castration-sensitive or castration-resistant setting increases survival, resistance is universal and limits the efficacy of subsequent hormonal therapies. Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase that regulates mitotic functions and promotes the progression of cells through mitosis, and it is highly upregulated in prostate cancer following castration. PLK1 inhibition enhances the efficacy of abi in

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Einstein, David Johnson, Atish Dipankar Choudhury, Philip James Saylor, et al. "A phase II study of onvansertib in combination with abiraterone and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC)." Journal of Clinical Oncology 38, no. 6_suppl (2020): TPS266. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.tps266.

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TPS266 Background: Metastatic CRPC remains a leading cause of cancer-related deaths worldwide. Although abiraterone (abi) in either the castration-sensitive or castration-resistant setting increases survival, resistance is universal and generally occurs within 9-16 months of initiating treatment. Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase that regulates mitotic functions and progression, and it is highly upregulated in prostate cancer following castration. PLK1 inhibition enhances the efficacy of abi in cell line models and patient-derived tumor xenografts via several mecha

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Contoux, C., G. Ramstein, and A. Jost. "Modelling the mid-Pliocene Warm Period climate with the IPSL coupled model and its atmospheric component LMDZ5A." Geoscientific Model Development 5, no. 3 (2012): 903–17. http://dx.doi.org/10.5194/gmd-5-903-2012.

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Abstract. This paper describes the experimental design and model results of the climate simulations of the mid-Pliocene Warm Period (mPWP, ca. 3.3–3 Ma) using the Institut Pierre Simon Laplace model (IPSLCM5A), in the framework of the Pliocene Model Intercomparison Project (PlioMIP). We use the IPSL atmosphere ocean general circulation model (AOGCM), and its atmospheric component alone (AGCM), to simulate the climate of the mPWP. Boundary conditions such as sea surface temperatures (SSTs), topography, ice-sheet extent and vegetation are derived from the ones imposed by the Pliocene Model Inter

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Nguyen, Anthony T., Tahir B. Dar, Jolene Viramontes, et al. "Abstract 6409: Non-redundant mechanisms of immune resistance to radiotherapy converge on innate immunity." Cancer Research 83, no. 7_Supplement (2023): 6409. http://dx.doi.org/10.1158/1538-7445.am2023-6409.

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Abstract Multiple studies have demonstrated synergy between immune checkpoint blockade (ICB) and radiotherapy (RT) in preclinical murine models; however, randomized trials of RT/ICB have been inconsistent in patients with solid tumors. To better understand this discordance, we hypothesized that there are non-redundant inhibitory immune pathways that restrain the efficacy of RT beyond T-cell oriented immune checkpoints. To this end, we performed scRNA-seq and CITE-seq analysis of the EO771 syngeneic murine model of breast cancer to characterize the immune landscape following RT±ICB. We found th

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Baer, Hallie, Jessica Simon, Lara McKean-Baste, et al. "Abstract 1487: Role of micro-RNA199a-3p in lymph node stromal extracellular vesicles on tumorigenesis in colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): 1487. http://dx.doi.org/10.1158/1538-7445.am2022-1487.

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Abstract Introduction: MicroRNAs (miRNAs) are short non-coding RNAs implicated in post-transcriptional regulation of gene expression. Abnormal expression of miRNAs in cancer is associated with enhanced tumorigenesis and metastatic potential. Our previous data has shown that extracellular vesicles (EV) secreted by human lymph node stromal cells (LNSC) enhance tumorigenesis in colorectal cancer (CRC). By systemic searching and modifying miRNAs carried by EV through overexpression and inhibition on LNSC, we aim to demonstrate their effect on CRC progression in vitro and orthotopic mouse model. Me

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Ishii, Toru, Makoto Kawai, Christina Chick, Isabelle Cotto, Joachim Hallmayer, and Ruth O'hara. "0789 Sleep Spindle Density is Associated with Core Symptom Severity in Autism Spectrum Disorder." SLEEP 46, Supplement_1 (2023): A348. http://dx.doi.org/10.1093/sleep/zsad077.0789.

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Abstract Introduction Converging evidence suggests that dysregulation of thalamocortical interactions, mediated by the thalamic reticular nucleus (TRN), contributes to the expression of autism spectrum disorder (ASD). Risk genes for ASD have been found to affect the TRN early in development. Two hallmarks of NREM sleep –slow oscillations (SO) and sleep spindles– reflect TRN function and distinct thalamic/thalamocortical circuits. While studies demonstrate disrupted sleep quality that correlates with symptoms in children with ASD, studies of spindles in ASD have produced inconsistent findings.

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Roksandić, Miodrag M. "On: “3-D seismic imaging and seismic attribute analysis of genetic sequences deposited in low‐ accommodation conditions” (B. A. Hardage, D. L. Carr, D.E. Lancaster, J. L. Simmons Jr., D. S. Hamilton, R. Y. Elphick, K. L. Oliver, and R. A. Johns, GEOPHYSICS, 61, 1351–1362)." GEOPHYSICS 62, no. 6 (1997): 1996–98. http://dx.doi.org/10.1190/1.1444300.

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The paper deals with the results of a multidisciplinary study of the Bend Conglomerate (Middle Pennsylvanian fluvio‐deltaic clastics) in a portion of Boonsville gas field in the Fort Worth Basin of North‐Central Texas, especially with those related to the Caddo sequence, at the top of the Bend Conglomerate. The purpose of the study was “to determine how modern geophysical, geological, and engineering techniques could be combined to understand the mechanisms by which fluvio‐deltaic depositional processes create reservoir compartmentalization in a low‐ to moderate‐accommodation basin.” According

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D'Angelo, Egidio, Paola Rossi, Simona Armano, and Vanni Taglietti. "Evidence for NMDA and mGlu Receptor-Dependent Long-Term Potentiation of Mossy Fiber–Granule Cell Transmission in Rat Cerebellum." Journal of Neurophysiology 81, no. 1 (1999): 277–87. http://dx.doi.org/10.1152/jn.1999.81.1.277.

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D'Angelo, Egidio, Paola Rossi, Simona Armano, and Vanni Taglietti. Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber–granule cell transmission in rat cerebellum. J. Neurophysiol. 81: 277–287, 1999. Long-term potentiation (LTP) is a form of synaptic plasticity that can be revealed at numerous hippocampal and neocortical synapses following high-frequency activation of N-methyl-d-aspartate (NMDA) receptors. However, it was not known whether LTP could be induced at the mossy fiber–granule cell relay of cerebellum. This is a particularly interesting issue because t

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Koffler, Daniel, Jacob Eckstein, Joseph Herman, et al. "Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon’s two-stage trial." BMJ Open 13, no. 4 (2023): e064809. http://dx.doi.org/10.1136/bmjopen-2022-064809.

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IntroductionCurative intent treatment of head and neck cancer (HNC) is frequently radiation therapy over 7 weeks with concurrent chemotherapy. This regimen is effective but carries a burden of toxicity leading to severe pain and treatment breaks portending inferior outcomes. Conventional palliation methods include opioids, anticonvulsants and local anaesthetics. Breakthrough toxicities are nevertheless ubiquitous and present an urgent unmet need. Ketamine is an inexpensive drug with mechanisms of analgesia outside the opioid pathway including N-methyl-D-aspartate (NMDA) receptor antagonism and

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