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Rozprawy doktorskie na temat „Small animal imaging”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Evans, Eleanor. "Improved quantification in small animal PET/MR." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252640.

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In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a result of disease progression. The combination of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides excellent soft tissue contrast from MRI with exceptional sensitivity and specificity from PET. This thesis explores the use of sequentially acquired PET and MR images to improve the quantification of small animal PET data. The primary focus was to improve image-based estimates

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Weisenberger, Andrew Gerard. "Gamma-ray imaging detector for small animal research." W&M ScholarWorks, 1998. https://scholarworks.wm.edu/etd/1539623944.

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A novel radiation imaging technology for in vivo molecular imaging in small mammals is described. The goal of this project is to develop a new type of imaging detector system suitable for real-time in vivo probe imaging studies in small animals. This technology takes advantage of the gamma-ray and x-ray emission properties of the radioisotope iodine 125 (125I) which is employed as the label for molecular probes. The radioisotope 125I is a gamma-ray emitting radioisotope that can be commercially obtained already attached to biomedically interesting molecules to be used as tracers for biomedical

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MANFREDI, MARTINA. "IMAGING THE SENTINEL LYMPH NODE IN SMALL ANIMAL ONCOLOGY." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/829131.

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Sentinel lymph node (SLN) biopsy has become the cornerstone for tumor staging in patients affected by different solid tumors. To identify the first lymph node draining the tumor site, several mapping modalities have been investigated in human medicine and applied in veterinary oncology, either as experimental models or in clinical setting. In this dissertation, after an extensive literature review, we investigate the principal SLN imaging techniques, such as lymphoscintigraphy, which is considered the gold standard in human oncology, the use of blue dye and computed tomography (CT)-indirect ly

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4

Larsson, Daniel. "Small-Animal Imaging with Liquid-Metal-Jet X-Ray Sources." Doctoral thesis, KTH, Biomedicinsk fysik och röntgenfysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-163169.

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Small-animal x-ray imaging is an important tool for medical research. The penetration power of x-rays makes it possible to investigate the 3D structure of small animals and other thick biological samples by computed tomography (CT). However, small-animal x-ray imaging often requires high resolution due to the small structures involved, and short exposure times due to sample movement. This constitutes a challenge, since these two properties require compact x-ray sources with parameters that are not widely available. In this Thesis we present the first application of liquid-metal-jet sources for

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Qian, Jianguo. "A versatile imaging system for in vivo small animal research." W&M ScholarWorks, 2008. https://scholarworks.wm.edu/etd/1539623532.

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In vivo small animal imaging has become an essential technique for molecular biology studies. However, requirements of spatial resolution, sensitivity and image quality are quite challenging for the development of small-animal imaging systems. The capabilities of the system are also significant for carrying out small animal imaging in a wide range of biological studies. The goal of this dissertation is to develop a high-performance imaging system that can readily meet a wide range of requirements for a variety of small animal imaging applications. Several achievements have been made in order t

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6

Terrin, Massimo. "Micro-CT for small animal imaging : Optimization of the tube voltage for low-contrast imaging." Thesis, KTH, Skolan för teknik och hälsa (STH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176482.

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This master thesis evaluated the optimal tube voltage for low-contrast imaging of a micro-CT system (intended for small animal imaging) built at the School of Technology and Health (STH) of the Royal Institute of Technology (KTH). The main goal of this work was to calibrate the above-mentioned device (composed moreover by a Hamamatsu microfocus L10951-01 X-ray tube, a CMOS flat panel Hamamatsu C7942CA-22 and using a Cone-Beam CT reconstruction algorithm) for obtaining the best imaging of low-contrast structures. In order to do this, an analytical model, re-adapted from the previous state-of-t

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Manivannan, Niranchana. "Use of Multiple Imaging Views for Improving Image Quality in Small Animal MR Imaging Studies." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1436753010.

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Daibes, Figueroa Said. "Discrete NaI(TI) crystal detector optimization for small animal SPECT molecular imaging." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/5821.

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Thesis (Ph.D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (November 15, 2006) Vita. Includes bibliographical references.

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9

Cooper, Reynold James. "Performance of the SmartPET Positron Emission Tomography System for Small Animal Imaging." Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491374.

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The experimental results presented in this study demonstrate the performance of a prototype Positron Emission Tomography system utilising planar HPGe detector technology. The experimental measurements undertaken provide evidence of the feasibility of such a system for small animal imaging. It has been shown how the use of digital Pulse Shape Analysis techniques may be employed in order to improve the achievable image quality. By performing high precision scans of one the SmartPET HPGe detectors with finely collimated gamma-ray beams at a range of energies the performance and response of the de

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Kujala, Naresh Gandhi Yu Ping. "Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/7021.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 26, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Ping Yu. Vita. Includes bibliographical references.

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11

Valastyán, Iván. "Software Solutions for Nuclear Imaging Systems in Cardiology, Small Animal Research and Education." Doctoral thesis, KTH, Medicinsk teknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12069.

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The sensitivity for observing physiological processes makes nuclear imaging an important tool in medical diagnostics. Different types of nuclear imaging modalities, with emphasis on the software components and image reconstructions, are presented in this thesis: the Cardiotom for myocardial heart studies at the Karolinska University Hospital, the small animal Positron Emission Tomograph (PET) scanners for research and the SPECT, PET, spiral CT and Cardiotom demonstrators for the Royal Institute of Technology medical imaging laboratory. A modular and unified software platform has been develope

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Citro, Lucas Abraham. "High-field Cardiac Magnetic Resonance Imaging in Small Animal Models of Cardiovascular Disease." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1365082830.

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13

Rasmussen, John C. "Development of a radiative transport based, fluorescence-enhanced, frequency-domain small animal imaging system." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1067.

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Konik, Arda Bekir. "Evaluation of attenuation and scatter correction requirements in small animal PET and SPECT imaging." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/691.

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Positron emission tomography (PET) and single photon emission tomography (SPECT) are two nuclear emission-imaging modalities that rely on the detection of high-energy photons emitted from radiotracers administered to the subject. The majority of these photons are attenuated (absorbed or scattered) in the body, resulting in count losses or deviations from true detection, which in turn degrades the accuracy of images. In clinical emission tomography, sophisticated correction methods are often required employing additional x-ray CT or radionuclide transmission scans. Having proven their potential

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15

Ambrosini, Valentina <1975&gt. "Pre-clinical imaging: small animal pet and CT applications in pneumology, oncology and cardiology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1087/1/Tesi_Ambrosini_Valentina.pdf.

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Ambrosini, Valentina <1975&gt. "Pre-clinical imaging: small animal pet and CT applications in pneumology, oncology and cardiology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1087/.

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Hesterman, Jacob Yost. "The Multi-Module, Multi-Resolution SPECT System: A Tool for Variable-Pinhole, Small-Animal Imaging." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/196056.

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The multi-module, multi-resolution SPECT system (M3R) was developed and evaluated at the University of Arizona's Center for Gamma-Ray Imaging (CGRI). The system consists of four modular gamma cameras stationed around a Cerrobend shielding assembly. Slots machined into the shielding allow for the easy interchange of pinhole apertures, providing M3R with excellent hardware flexibility. Motivation for the system included serving as a prototype for a tabletop, small-animal SPECT system, acting as a testbed for image quality by enabling the experimental validation of imaging theory, and aiding i

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Trumbull, Tara. "Simulation and Analysis of an Adaptive SPECT Imaging System for Tumor Estimation." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144580.

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We have developed a simulation of the AdaptiSPECT small-animal Single Photon Emission Computed Tomography (SPECT) imaging system. The simulation system is entitled SimAdaptiSPECT and is written in C, NVIDIA CUDA, and Matlab. Using this simulation, we have accomplished an analysis of the Scanning Linear Estimation (SLE) technique for estimating tumor parameters, and calculated sensitivity information for AdaptiSPECT configurations.SimAdaptiSPECT takes, as input, simulated mouse phantoms (generated by MOBY) contained in binary files and AdaptiSPECT configuration geometry contained in ASCII tex

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19

Kwon, Sun Kuk. "Dynamic fluorescence imaging with molecular agents for cancer detection." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1064.

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Vandervoort, Eric. "Improving attenuation corrections obtained using singles-mode transmission data in small-animal PET." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/608.

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The images in positron emission tomography (PET) represent three dimensional dynamic distributions of biologically interesting molecules labelled with positron emitting radionuclides (radiotracers). Spatial localisation of the radio-tracers is achieved by detecting in coincidence two collinear photons which are emitted when the positron annihilates with an ordinary electron. In order to obtain quantitatively accurate images in PET, it is necessary to correct for the effects of photon attenuation within the subject being imaged. These corrections can be obtained using singles-mode photon transm

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21

Roy, Debashish. "3D Cryo-Imaging System For Whole Mouse." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1259006676.

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Akinyi, Teckla G. "An Affordable Open-Source Small Animal MR and Hyperpolarized Gas Compatible Ventilator: Feasibility in preclinical imaging." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490354672385997.

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Şensoy, Levent. "Geo-Pet : a novel generic Organ-Pet for small animal organs and tissues." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3186.

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Reconstructed tomographic image resolution of small animal PET imaging systems is improving with advances in radiation detector development. However the trend towards higher resolution systems has come with an increase in price and system complexity. Recent developments in the area of solid-state photomultiplication devices like silicon photomultiplier arrays (SPMA) are creating opportunities for new high performance tools for PET scanner design. Imaging of excised small animal organs and tissues has been used as part of post-mortem studies in order to gain detailed, high-resolution anatomical

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Tapfer, Arne [Verfasser], Franz [Akademischer Betreuer] Pfeiffer, and Axel [Akademischer Betreuer] Haase. "Small Animal X-ray Phase-Contrast Imaging / Arne Tapfer. Gutachter: Axel Haase ; Franz Pfeiffer. Betreuer: Franz Pfeiffer." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/104227701X/34.

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Attarwala, Ali Asgar [Verfasser], and Frederik [Akademischer Betreuer] Wenz. "Development and evaluation of quantitative imaging for improved estimation of radiopharmaceutical bio-distribution in small animal imaging / Ali Asgar Attarwala ; Betreuer: Frederik Wenz." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1177688883/34.

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Edjlali, Ehsan. "Fluorescence diffuse optical tomographic iterative image reconstruction for small animal molecular imaging with continuous-wave near infrared light." Thèse, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/10673.

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L’approximation par harmoniques sphériques (SPN) simplifiées de l’équation de transfert radiatif a été proposée comme un modèle fiable de propagation de la lumière dans les tissus biologiques. Cependant, peu de solutions analytiques ont été trouvées pour ce modèle. De telles solutions analytiques sont d’une grande valeur pour valider les solutions numériques des équations SPN, auxquelles il faut recourir dans le cas de tissus avec des géométries courbes complexes. Dans la première partie de cette thèse, des solutions analytiques pour deux géométries courbes sont présentées pour la premiè

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Pesnel, Sabrina. "Développement de modalités d'imagerie in vivo pour l'oncologie expérimentale." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00597262.

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L'imagerie in vivo du petit animal est de plus en plus utilisée en pharmacologie pour identifier et caractériser l'activité de nouveaux agents anticancéreux.La première partie de ma thèse a consisté à développer des outils pour améliorer la quantification enbioluminescence. Une méthode, basée sur les caractéristiques spectrales des photons émis, a été établie pour corriger l'absorption tissulaire. La seconde, faisant appel aux méthodes de restauration d'images, avait pour but de corriger la diffusion pour augmenter la résolution. Dans un second temps, j'ai mis en place des modèles in vivo de t

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Choi, Woo Jhon. "Structural and functional imaging of the human and small animal eyes using ultrahigh speed Fourier domain optical coherence tomography." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/93058.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Optical coherence tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid noninvasively and in vivo, which have led OCT to be a clinical standard for the diagnosis of a

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Foudray, Angela Marie Klohs. "Design of an advanced positron emission tomography detector system and algorithms for imaging small animal models of human disease." Diss., [La Jolla, Calif.] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3344655.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed March 19, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 404-423).

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Ma, Rui Verfasser], Vasilis [Akademischer Betreuer] Ntziachristos, and Thorsten [Akademischer Betreuer] [Hugel. "Development of multispectral optoacoustic imaging for high resolution small animal visualization / Rui Ma. Gutachter: Thorsten Hugel ; Vasilis Ntziachristos. Betreuer: Vasilis Ntziachristos." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1031075488/34.

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Akkoul, Smaïl. "Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00585392.

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Cette thèse est consacrée au traitement d'images de bioluminescence chez le petit animal. Ce type d'imagerie, bien qu'utilisé en routine pour la recherche en cancérologie par exemple, présente néanmoins des problèmes liés aux phénomènes de diffusion et d'absorption par les tissus internes à l'animal. Il s'ajoute à cela le bruit du système d'acquisition ainsi que le bruit lié aux rayonnements cosmiques. Ceci influe sur la qualité des images acquises et rend leur exploitation délicate. Le but de cette thèse est de compenser ces effets perturbateurs. Les travaux menés ont abouti à la proposition

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Di, Sopra Lorenzo. "Geometric Misalignment Calibration and Detector Lag Effect Artifact Correction in a Cone-Beam Flat Panel micro-CT System for Small Animal Imaging." Thesis, KTH, Skolan för teknik och hälsa (STH), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-179873.

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The cone-beam flat panel micro-CT is a high definition imaging system. It acquires projections of an object or animal to reconstruct a 3D image of its internal structure. The device is basically composed by a radiation tube and a detector panel, which are fixed to a gantry that rotates all around the test subject. The micro-CT system is affected by several imperfections and problems, that might lead to serious artifacts that deteriorate the quality of the reconstructed image. In particular, two issues have been discussed in the present work: the source-panel geometric misalignment and the dete

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Lefrançois, William. "Développements méthodologiques en imagerie cardiovasculaire par résonance magnétique chez le petit animal." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21833/document.

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L’imagerie cardiovasculaire du rongeur par RMN est un véritable défi en ce qui concerne la résolution spatiale et temporelle, le contraste et le temps d’expérience. S’il est aujourd’hui admis que l’acquisition 3D doit être privilégiée chez le petit animal, les temps d’acquisition en 3D sont parfois très longs. Ils doivent pourtant rester compatibles avec les temps d’expérience in vivo. L’objectif de cette thèse était donc de développer de nouvelles méthodes d’imagerie cardiovasculaire 3D rapides pour le petit animal à 4.7 et 9.4 T. Tout d’abord, nous avons développé deux méthodes d’IRM cardiaq

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Namati, Jacqueline Thiesse. "Phenotype characterization of lung structure in inbred mouse strains using multi modal imaging techniques." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/256.

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Research involved in modeling human lung disease conditions has provided insight into disease development, progression, and treatment. In particular, mouse models of human pulmonary disease are increasingly utilized to characterize lung disease conditions. With advancements in small animal imaging it is now possible to investigate the phenotypic differences expressed in inbred mouse strains in vivo to investigate specific disease conditions that affect the lung. In this thesis our aim was to generate a comprehensive characterization of the normative mouse lung phenotypes in three of the most u

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Cosette, Jérémie. "Design and optimization of small animal non-invasive imaging approaches for evaluating the effects of innovative treatments of Primary Central Nervous System Lymphomas." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T069/document.

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Pas de résumé en français<br>Primary central nervous system lymphomas (PCNSL) are very aggressive malignancies with poor survival rate even with treatments (survival median is 44 months). This disease affects immune cells (lymphocytes) and forms diffuse and non-surgically removable tumor in the central nervous system. High-dose chemotherapy and radiotherapy are the common treatments with severe side effects. New therapeutic approaches are required for increasing treatment efficiency. We focused on primary intraocular lymphomas (PIOL) and primary cerebral lymphomas (PCL), which are subtypes of

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Rabell, Montiel Adela. "Development of acoustic tissue mimicking materials for preclinical ultrasound imaging applications." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31342.

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Many applications of ultrasound test phantoms require that the acoustical properties of the phantom should closely match those of soft tissue. Numerous commercial test phantoms of this type are available for use with clinical ultrasound scanners, which use frequencies up to 20 MHz. However, scanners designed for imaging small animals in preclinical studies, typically operate at much higher frequencies. No commercially available test phantoms exist for use at frequencies above 20 MHz. The aim of this work was to develop a tissue-mimicking-material (TMM) that closely matches the acoustic propert

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Bergeron, Mélanie. "Construction et expérimentation d'un scanner bimodal TEP/TDM combiné de résolution spatiale submillimétrique pour petits animaux." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6755.

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Résumé : La tomographie d’émission par positrons (TEP) permet une imagerie fonctionnelle et moléculaire qui peut bénéficier de l’utilisation conjointe de la tomodensitométrie (TDM), d’abord pour fournir un support anatomique aux images TEP, mais aussi pour permettre une correction plus précise des images TEP. Les appareils existants sont composés de deux scanners juxtaposés nécessitant un déplacement du sujet entre les deux acquisitions, ce qui peut causer des artéfacts de mouvement dans l’image fusionnée TEP/TDM. De plus, le mode de fonctionnement des scanners TDM, basé sur l’intégration du f

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Dillenseger, Jean-Philippe. "Imagerie préclinique multimodale chez le petit animal : qualification des instruments et des méthodes (IRM, µTDM et µTEMP)." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAD026/document.

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L’imagerie préclinique se pratique majoritairement sur des modèles animaux murins principalement des souris (61%), elle représente une étape indispensable en recherche préclinique car elle suit les deux premières recommandations de la règle des 3R (réduction, raffinement et remplacement). Pour donner une signification biologique aux mesures extraites des images acquises in vivo chez la souris, il est nécessaire d’évaluer les performances des instruments utilisés mais également des procédures expérimentales en jeu. La qualification des appareils nécessite l’usage de fantômes spécifiques, et l’é

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Brard, Emmanuel. "La tomographie à émission de positrons à géométrie axiale : de l’imagerie de la souris au cerveau humain." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAE003/document.

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La tomographie par émission de positrons est une technique d’imagerie nucléaire utilisant des noyaux radioactifs. Elle est utilisée dans le domaine clinique et préclinique. Cette dernière nécessite l’utilisation de petits animaux, comme la souris. Comme en imagerie clinique, l’objectif est d’obtenir le meilleur signal avec la meilleure précision spatiale possible. Cependant, un rapport d’échelle homme-souris suggère une résolution inférieure à 1 mm3. Un imageur conventionnel est constitué de modules de détection entourant le patient, orientés radialement. Cette approche lie efficacité et résol

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Ma, Xiaopeng [Verfasser], Vasilis [Akademischer Betreuer] [Gutachter] Ntziachristos, Moritz G. F. [Gutachter] Wildgruber, and Bernhard [Gutachter] Wolfrum. "Assessment of hybrid FMT-XCT for respiratory and cardiovascular small animal imaging applications / Xiaopeng Ma ; Gutachter: Moritz G. F. Wildgruber, Bernhard Wolfrum, Vasilis Ntziachristos ; Betreuer: Vasilis Ntziachristos." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1126644110/34.

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Bled, Emilie. "Développements méthodologiques de l’IRM en 3D chez la souris : résolution temporelle et sensibilité du contraste." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21934.

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Pour répondre à des questions biologiques émergentes, l’IRM 3D in vivo est une approche de choix, mais elle souffre principalement d’une faible résolution temporelle en raison d’une faible sensibilité. Par ailleurs, l’IRM gagnerait à une meilleure sensibilité aux agents de contrastes exogènes. Il est proposé ici des développements en IRM du petit animal permettant de réduire considérablement la durée d’acquisition des images à trois dimensions chez la souris, ou la détection de très faibles quantités d’agents de contraste. Ces développements reposent sur la manipulation de l’espace-k (espace d

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Namati, Eman, and eman@namati com. "Pre-Clinical Multi-Modal Imaging for Assessment of Pulmonary Structure, Function and Pathology." Flinders University. Computer Science, Engineering and Mathematics, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081013.044657.

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In this thesis, we describe several imaging techniques specifically designed and developed for the assessment of pulmonary structure, function and pathology. We then describe the application of this technology within appropriate biological systems, including the identification, tracking and assessment of lung tumors in a mouse model of lung cancer. The design and development of a Large Image Microscope Array (LIMA), an integrated whole organ serial sectioning and imaging system, is described with emphasis on whole lung tissue. This system provides a means for acquiring 3D pathology of fixed w

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Omidvari, Negar [Verfasser], Stephan [Akademischer Betreuer] Paul, Stephan [Gutachter] Paul, and Sibylle [Gutachter] Ziegler. "Development and Characterization of MADPET4: A High Resolution Small Animal Positron Emission Tomography Insert for a 7 T Magnetic Resonance Imaging Scanner / Negar Omidvari ; Gutachter: Stephan Paul, Sibylle Ziegler ; Betreuer: Stephan Paul." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1170872611/34.

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Kastis, Georgios. "Multi-modality imaging of small animals." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/289830.

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Over the last few years there has been a great demand for noninvasive, dedicated, small-animal imaging systems for biomedical research applications. In this dissertation we will discuss the development and performance of two gamma-ray systems and a dual modality CT/SPECT system. Initially we introduce FASTSPECT, a stationary, scintillator-based, single-photon emission computed tomography (SPECT) system that was originally built as a brain imager. We discuss its transformation into a small-animal imaging system and validate its performance by presenting high-resolution images of phantoms and an

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Jiménez, González Xavier. "Improvements in the registration of multimodal medical imaging : application to intensity inhomogeneity and partial volume corrections." Doctoral thesis, Universitat Politècnica de Catalunya, 2016. http://hdl.handle.net/10803/458881.

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Alignment or registration of medical images has a relevant role on clinical diagnostic and treatment decisions as well as in research settings. With the advent of new technologies for multimodal imaging, robust registration of functional and anatomical information is still a challenge, particular in small-animal imaging given the lesser structural content of certain anatomical parts, such as the brain, than in humans. Besides, patient-dependent and acquisition artefacts affecting the images information content further complicate registration, as is the case of intensity inhomogeneities (IIH) s

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Manook, André [Verfasser], Markus [Akademischer Betreuer] Schwaiger, and Johann [Akademischer Betreuer] Förstl. "Preclinical PET as Translational Tool for Imaging Alzheimer's Disease : Small-Animal PET Imaging of Beta-Amyloid Plaques with [11C]PiB, its Multi-Modal Validation and Application to the Evaluation and Ranking of New AD Tracers / André Manook. Gutachter: Markus Schwaiger ; Johann Förstl. Betreuer: Markus Schwaiger." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1047883465/34.

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Portal, Loriane. "Etude de la tomographie à comptage de rayons X avec des pixels hybrides en Si et en CdTe et application au suivi longitudinal du carcinome hépatocellulaire chez la souris." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0351/document.

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Ma thèse de doctorat s’inscrit à l’interface entre la physique expérimentale et la biologie. Ce travail a été développé au sein de l’équipe imXgam du CPPM, qui a construit un prototype de micro-tomographie pour le suivi non-invasif du petit animal, équipé d’une caméra à pixels hybrides XPAD3 fonctionnant en mode comptage de rayons X. Le comptage de rayons X rendu possible par la technologie des pixels hybrides, permet de s’affranchir du bruit électronique et d’augmenter ainsi la détectabilité des tissus faiblement contrastés. Elle présente de plus la capacité d'appliquer à chaque pixel un seui

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Marchadier, Arnaud. "Analyses d'images de tomographie X chez le petit animal : applications aux études de phénotypage ex vivo et in vivo." Phd thesis, Université d'Orléans, 2011. http://tel.archives-ouvertes.fr/tel-00779806.

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L'imagerie du petit animal est incontournable pour le développement des recherches dans les secteurs de labiologie, de la médecine et de l'industrie pharmaceutique. Parmi les différentes modalités d'imagerie développéeschez l'humain et adaptées à l'animal, l'imagerie tomographique à rayons X est devenue une référencepour l'analyse des caractères anatomiques et phénotypiques chez la souris. Elle permet de réaliser des étudeslongitudinales in vivo et des analyses haute résolution ex vivo de façon non invasives et en 3D. L'analyse deces images 3D nécessite des outils spécifiques à chaque probléma

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Brullé, Laura. "Développement de stratégies d'imagerie multimodalités pour la pharmacologie des agents anticancéreux." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00747343.

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L'imagerie préclinique dans le domaine de la cancérologie est en plein essor. Elle permet grâce à des modèles animaux représentatifs de cancers humains de comprendre les mécanismes de développement des pathologies et d'évaluer l'efficacité thérapeutique d'un nouveau traitement. Le principal objectif de ce travail a été de développer deux modèles orthotopiques de cancer (pancréas et colon) et d'évaluer des traitements de références ainsi qu'une nouvelle stratégie thérapeutique par plasma froid fibré appelée Plasma Gun. Les 2 modèles de cancers développés ont montré une bonne représentativité vi

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El, Ketara Samir. "Développement d'une micro-sonde bêta⁺ télémétrique basée sur la technologie CMOS pixélisée pour des études cérébrales in vivo chez le rat vigile et libre de ses mouvements." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASP159.

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La Tomographie par émission de Positrons (TEP) est une technique d’imagerie qui se distingue par sa grande sensibilité (pmole/ml) et sa capacité de quantification adaptés à l’analyse de nombreux mécanismes cérébraux à l’échelle moléculaire. De par ses caractéristiques, elle présente un grand intérêt en neurosciences que ce soit dans le domaine clinique (TEP chez l’humain) ou préclinique (micro-TEP adapté au rongeur) et permet de mieux diagnostiquer et suivre des maladies ou troubles cérébraux (dépression, addiction, psychiatrie). Dans ce contexte, la corrélation entre la neuroimagerie molécula

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