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1

Mohd, Abdul Hadi. "FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF FELODIPINE FOR THE TREATMENT OF HYPERTENSION." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4781–90. https://doi.org/10.5281/zenodo.1091572.

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Sublingual administration of the drug means placement of the drug under the tongue and drug reaches directly in to the blood stream through the ventral surface of the tongue and floor of the mouth. The concept of formulating Sublingual tablets of Felodipine (antihypertensive drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two synthetic superdisintegrants (crospovidone and sodium starch glycollate) In the present work comparison between crospovidone and s
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Sepuri, Vijayalaxmi and N. Umasri. "FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF TENOFOVIR DISOPROXIL FUMARATE (TDF) IMMEDIATE RELEASE TABLETS." Indo Am. J. P. Sci, 2017 04, no. 05 (2017): 1229–41. https://doi.org/10.5281/zenodo.583712.

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In the present work, an attempt has been made to develop immediate release tablets of Tenofovir Disoproxil Fumarate (TDF). In the present work Sodium starch glycollate and Cross carmellose sodium were employed as super disintegrating agents for the selected drug molecule.. All the formulations were prepared by wet granulation method. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Am
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Singh, Sudarshan, S. S. Shyale, and G. Bhosale. "Formulation and Evaluation of Mouth Dissolving Tablets of Piroxicam." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2941–46. http://dx.doi.org/10.37285/ijpsn.2015.8.3.8.

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Piroxicam, a non-steroidal anti-inflammatory agent, is widely used in rheumatoid arthritis, osteoarthritis, musculo-skeletal disorders, dysmenorrhoeal and post-operative pain. It has poor bioavailability due to its inherent properties. The objective of present study is to enhance water solubility of Piroxicam by solid dispersion technique and to develop novel method of preparing compressed tablets for Piroxicam with high porosity which dissolves rapidly in mouth, using camphor as sublimating agent and super disintegrants such as Crosscarmellose sodium and sodium starch glycollate. The tablets
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Shanmugam, S., Dr Senthil, and T. Ventrichelvan. "Formulation and evaluation of loratadine mouth dissolving tablet." Bangladesh Journal of Scientific and Industrial Research 48, no. 2 (2013): 137–42. http://dx.doi.org/10.3329/bjsir.v48i2.15745.

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Loratadine 10 mg mouth dissolving tablet (MDT) was prepared by using super disintegrant such as sodium starch glycollate, crosscarmellose sodium, crospovidone at various concentration, aspartame was used as sweetening agent. The excipients were used for this study was based on the compatibillity studies. All the formulation was prepared by direct compression method. Among all the formulations crospovidone at 10 mg/tab gives 99.1% drug release at end of 12th min. It was considered as optimized batch. The optimized batch was processed for all the evaluation parameter and stability studies. The f
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Maji, Subhajit, and Mrs Vasia. "Development Optimization and Evaluation of Fast Disintegrating Tablets of Antiepileptic Drug Carbamazepine." Journal of Drug Discovery and Therapeutics 11, no. 1 (2023): 19–27. http://dx.doi.org/10.32553/jddt.v11i1.452.

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Background: The main objective of present research work is to formulate the Carbamazepine as Fast Disintegrating tablets to give fast relief and an increase in the patient compliance. Carbamazepine, an antiepileptic, belongs to BCS Class-II and used to control some types of seizures in the treatment of epilepsy and Neuropathic Pain by blocking use-dependent sodium channels.
 Methods: The powdered materials were compressed by direct compression technique using super disintegrants like sodium starch glycollate, croscarmellose sodium and starch, Magnesium Stearate and Di Calcium Phosphate ar
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6

V., Rajesh Babu V. Mallikarjun Abdul Sayeed P. Rajasridhar Rao. "DESIGN AND EVALUATION OF MINI-TABLETS - PULSATILE DRUG DELIVERY SYSTEM OF RAMIPRIL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1839–49. https://doi.org/10.5281/zenodo.1211347.

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The aim of present study was to design and evaluate mini-tablets: pulsatile delivery of Ramipril based on chronophamaceutical approach for the treatment of hypertension. In the present study the immediate release core mini tablets were prepared by direct compression by using different superdisintegrantslike sodium starch glycollate, croscaramellose sodium and crospovidone. The optimized core tablets were then coated with PH sensitive polymers like Eudragit -S100 and Eudragit- L100. To get the desired dissolution profile various parameters like coating time and coat thickness studied. The formu
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7

Jeet, Kamal, Kapil Kumar, Aparna Joshi, Ikram Ikram, and Vaishali Rajput. "Development and Evaluation of Solid Dispersion Formulations of Olanzepine." Journal of Drug Delivery and Therapeutics 13, no. 10 (2023): 109–16. http://dx.doi.org/10.22270/jddt.v13i10.5985.

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The purpose of present study was to enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeation, wettability, XRD and FTIR analysis. Solid dispersions showed higher solubility and an improved drug release profile than the pure drug. Solid dispersion and physical mixture w
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8

Reddy, Dr D. RamaBrahma, Dr Ch N. V. S. Mastan Rao, K. John Abhi K. John Abhi, et al. "An Overview on Immediate Drug Release of Pravastatin Drug." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 847–50. https://doi.org/10.35629/4494-1001847850.

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The objective of this research was to formulate fast dissolving tablets of Pravastatin sodium that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Pravastatin sodium is used for the treatment of myocardial infarction. Fast dissolving tablets of pravastatin sodium were prepared by direct compression method using three different superdisintegrants-Sodium starch glycollate, Croscarmellose sodium and Crosspovidone (2%, 4% and 6%) and three different diluents (mannitol and spray dried lactose) in different concentrations. Eighteen formulations wer
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9

Yash, Paul, Tyagi Sarvan, and Singh Bhupinder. "Formulation and Evaluation of Oral Dispersible Tablets of Zidovudine with different Superdisintegrants." International Journal of Current Pharmaceutical Review and Research 2, no. 2 (2011): 82–91. https://doi.org/10.5281/zenodo.12698580.

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Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrate ordispersed in mouth without the need of water. In the present investigation eight ODTformulations of zidovudine, an antiretroviral drug, were prepared using differentsuperdisintegrants viz. Crospovidone (PPXL), Crosscarmellose sodium (Ac-di-sol) andsodium starch glycollate by direct compression method. The effects of disintegrants indifferent concentration on the release profile of zidovudine ODTs were studied. DevelopedODTs were studied for their physicochemical properties and in vitro drug release pro
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10

Singh Chundawat, Lokendra, and Vishal Sharma. "FORMULATION EVALUATION AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF PANTOPRAZOLE SODIUM BY THE USING OF DIFFERENT SUPERDISINTEGRANTS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 84. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.24595.

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Objective: The objective of this study was to formulate and optimize an orodispersible formulation of pantoprazole sodium using a 32 factorial design for optimized the superdisintegrant concentration. Methods: Various concentrations (2%, 4%, and 6%) of superdisintegrants (sodium starch glycollate [SSG] and crospovidone [CP]) were added in the formulation, all processing steps are carried out at a temperature below 250c and relative humidity <35%. Procedure to manufacture orodispersible tablets by direct compression was established. Results: The results show that the presence of a superdisin
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11

Deepak, Kumar Sarangi, Chandra Sekhar Patro, CH. Niranjan Patra, and Sanjeeb Kumar Sahoo. "In Vivo Assessment, Formulation, Characterization and Enhancing Pharmacotherapy of Encapsulated Mini Tablets for Immediate Release Sildenafil Citrate and Sustained Release Bosentan." DER PHARMA CHEMICA 15, no. 6 (2023): 7. https://doi.org/10.4172/0975-413X.15.6.127- -133.

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The objective of the current study is to formulate encapsulated sildenafil citrate Immediate Release (IR) and Bosentan sustained release Minitablets (MTs) for treating pulmonary arterial hypertension. This piece of research work signifies a targeted dosage form that is designed in the form of encapsulated minitablets taking different super disintegrants and polymers which produces superior product quality. In vivo pharmacokinetic studies of prepared mini tablets are also showed promising results. Using different concentrations of polymers like HPMC K15M, ethyl cellulose and sodium CMC for Bose
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12

Singh, Sudarshan, S. S. Shyale, and H. G. Sandip. "Improved Dissolution Properties of Ketoconazole through Application of Liquisolid Techniques." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3053–59. http://dx.doi.org/10.37285/ijpsn.2015.8.4.9.

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In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Ketoconazole. The liquisolid tablets were formulated with liquid medications, namely Propylene Glycol (PG) drug concentrations, 60% w/w, 70% w/w and 80% w/w. Avicel pH102 was used as a carrier material, Aerosil 200 as a coating material and Sodium starch glycollate as a super-disintegrant. Quality control tests, such as uniformity of tablet weight, uniformity of drug content, tablet hardness, friability test, disintegration and dissolution tests were performed t
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13

Singh, Sudarshan, S. S. Shyale, and P. Karade. "Formulation and Evaluation of Orally Disintegrating Tablets of Lamotrigine." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (2015): 2881–88. http://dx.doi.org/10.37285/ijpsn.2015.8.2.11.

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The aim of this study was to design orally disintegrating tablet (ODT) of Lamotrigine. It is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.46 mg/ml). Thus, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:1 molar ratios). The orally disintegrating tablet of lamotrigine was prepared by direct compression method using different concentration of superdisintegrants such as Sodium starch glycollate, croscarmell
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14

Preetesh, P. Sawant1 Rajashree Gude*2 Akshata J. Naik3 Saba Jamadar4. "Fabrication And Characterization of 3D Printed Fast Dissolving Oral Films of Ivabradine Hydrochloride." International Journal of Pharmacy and Biological Sciences (IJPBS) 15, no. 1 (2025): 6–17. https://doi.org/10.5281/zenodo.15035091.

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AbstractThree-dimensional (3D) printing technology is gaining significance due to its wide applications, rapid prototyping and customization. Fast-Dissolving Oral Films (FDOFs) provide an alternative approach to increase consumer acceptance by advantage of rapid disintegration and dissolution and administration without water. Combination of fused deposition modelling with preparation of the FDOFs seems to be extra advantageous in terms of pharmaceutical parameters. Ivabradine Hydrochloride was selected for formulating FDOF which is an Anti-Anginal drug. The aim of the present study is to fabri
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15

Kumar, Ravi Shankar, Loveleen, Indu Passi, Amandeep Kaur, and Sandeep Kumar Sharma. "Design Formulation and Evaluation of Anti Migraine Mouth Dissolving Tablets Using Different Super Disintegrants." Journal for Research in Applied Sciences and Biotechnology 3, no. 2 (2024): 282–94. http://dx.doi.org/10.55544/jrasb.3.2.44.

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The main objective of this research was to create and evaluate the efficacy of orally disintegrating tablets containing sumatriptan succinate at a dosage of 25 milligrammes, a medicine commonly prescribed for the treatment of migraines. The tablets are made using the direct compression method. In order to achieve best results, the formulations were enriched with microcrystalline cellulose of varying composition (Avicel PH 102), mannitol as a diluent, crospovidone, croscaramellose, and sodium starch glycollate as superdisintegrants. Carbomer (carbopol 940), Sodium CMC, and Sodium Alginate were
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16

Julie, E. James Sojan Abraham Joshua Bineesha K. B. Jicky T. Panicker Shaiju S. Dharan. "Formulation, Evaluation and Comparative Study of Effects of Super Disintegrants in Sublingual Fast Dissolving Niosomal Films of Nifedipine." British Journal of BioMedical Research 03, no. 04 (2019): 947–64. https://doi.org/10.24942/bjbmr.2019.526.

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The aim of the present work was to prepare and evaluate sublingual fast dissolving niosomal films containing Nifedipine with the purpose to achieve quick onset of action. Niosomes are utilized for prolonged release of the drug, and its film increases bioavailability via the sublingual route. Niosomes were prepared using span 60 and cholesterol at different drug to surfactant ratios. The niosomes were characterized for particle size and zeta-potential. The selected niosomal formulation was incorporated into polymeric films using hydroxypropyl methyl cellulose E15 and methyl cellulose as film-fo
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17

R., Subedi, Poudel K., Budhathoki U, and Thapa P. "Taste Masking and Formulation of Ondansetron Hydrochloride Mouth Dissolving Tablets." International Journal of Drug Delivery Technology 5, no. 3 (2015). http://dx.doi.org/10.25258/ijddt.v5i3.8877.

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This study was done to mask the bitter taste of ondansetron HCl using complexing agent, a polacrilex resin: Tulsion 335 and subsequently forming mouth dissolving tablet using superdisintegrants: Croscarmellose sodium and sodium starch glycollate. A preliminary screening was done. Batch process, a most preferential method for drug loading with ion exchange resins was selected. The process was optimized for drug: resin ratio to get maximum drug loading. A ratio of drug: resin at 1:3 was selected. Taste evaluation was carried out by selecting volunteers. Drug resin complex (DRC) was evaluated for
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18

K., L. Deepthi*1 B. Chatrapathi R. Bhaskar B. Jairam L. Gagan Kumar. "FORMULATION AND INVITRO EVALUATION OF MOUTH DISINTEGRATING TABLETS OF MONTELUKAST AND DESLORATADINE." November 30, 2018. https://doi.org/10.5281/zenodo.2530464.

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Montelukast sodium is a leukotriene receptor antagonist, used in the treatment of asthma and Desloratadine is a drug used to treat allergies. The combination formulation is used for the treatment of allergic rhinitis, chronic urticaria. The aim of the present study is to Formulate and evaluate the oral disintegrating tablets of Montelukast sodium and Desloratadine. ODTs were prepared by direct compression method and by using crospovidone, croscarmellose sodium and sodium starch glycollate as superdisintegrants which disintegrates in matter of seconds in the oral cavity, thereby reducing the ti
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19

Shaik, Asiya, and Nirmala D. "Formulation and in-vitro evaluation of floating pulsatile drug delivery of chronotherapeutic release of h2 receptor antagonist of famotidine." International Journal of Pharmaceutics and Drug Analysis, September 30, 2023, 86–91. http://dx.doi.org/10.47957/ijpda.v11i3.558.

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In the present study famotidine floating pulsatile drug delivery system was developed. Various type and different concentrations of superdisintegrants and polymer affect the drug release. FTIR studies concluded that there is no interaction between drug and excipients. Based on disintegration time and dissolution time the formulation (F2) which contains 8% sodium starch glycollate was optimised. The optimised formulation F2 was further coated with different concentrations of HPMC K4M,HPMC K 15M and HPMC K 100M..Based on the concentration of the coating layer and solubility of the coating layer
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Nath, Bipul, and Tushar Roy. "Compatibility Studies of Atorvastatin Calcium with Selected Excipients By Means of Thermal and FT-IR Spectroscopic Methods for the Development of Immediate Release Tablet." International Journal of Pharmaceutical Sciences and Drug Research 8, no. 03 (2016). http://dx.doi.org/10.25004/ijpsdr.2016.080310.

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The objectives of present investigation is to evaluate the compatibility of Atorvastatin calcium with immediate release excipients and to optimize the tablet which release is best comparable with innovator product by varying different super disintegrants. Various excipients used were sodium starch glycollate, cross carmellose sodium, cross-povidone, lactose, micro crystalline cellulose, mannitol, sodium lauryl sulfate, magnesium stearate, and stearic acid. Thermal characterization of the drug was done by DSC and FT-IR. From the DSC studies, the excipients such as microcrystalline cellulose (Av
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21

Ikhide B.O, Koreiocha J.N., Okon A.O., et al. "Processing of Natural Rubber Latex Concentrate (NRLC) Using A Novel Method of Creaming Based on Tamarind Kernel Powder (TKP) and Cassava Processing Effluents (CPE)." International Journal of Science & Technoledge, August 23, 2023. http://dx.doi.org/10.24940/theijst/2023/v11/i7/st2307-009.

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The purification and concentration of Natural Rubber Latex (NRL) can be achieved through the process of creaming. This is usually carried out by the addition of small quantities of some water-soluble colloids or creaming agents. Such include ammonium alginate, sodium alginate, sodium cellulose glycollate, methyl cellulose, aluminum cellulose glycollate, pectins, extract of carragheen moss, glue, gelatine, gum Arabic, gum acacia Senegal, locust bean gum, gum tragacanath, tamarind Kernel Powder, gum Karaya, and Polysaccharides such as maize, sorghum, rice, yam, potato starch and cassava starch.
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Ayesha, Naz Syeda Kulsum, Begum Mehraj, and Omer and Syed Naser Mohiuddin Mohammed. "FORMULATION AND INVITRO EVALUATION OF SOLID DISPERSION TABLETS OF SILYMARIN." December 20, 2021. https://doi.org/10.5281/zenodo.5824586.

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<strong>Objective:&nbsp;</strong>The research aims to formulate and evaluate Solid Dispersion tablets of Silymarin. <strong>Methods:&nbsp;</strong>Solid dispersions of Silymarin were prepared with various concentrations of carriers by using solvent evaporation method. The prepared solid dispersions were compressed into tablets by using 8 mm punch rotary tablet punching machine, with the hardness of 3.5kg /cm<sup>2</sup>.The formulated tablets were evaluated for various quality control parameters. <strong>Results:&nbsp;</strong>Silymarin was mixed with various proportions of excipients which sh
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