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Artykuły w czasopismach na temat „Somatostatin positive interneuron”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Halabisky, Brian, Fran Shen, John R. Huguenard, and David A. Prince. "Electrophysiological Classification of Somatostatin-Positive Interneurons in Mouse Sensorimotor Cortex." Journal of Neurophysiology 96, no. 2 (2006): 834–45. http://dx.doi.org/10.1152/jn.01079.2005.

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Classification of inhibitory interneurons is critical in determining their role in normal information processing and pathophysiological conditions such as epilepsy. Classification schemes have relied on morphological, physiological, biochemical, and molecular criteria; and clear correlations have been demonstrated between firing patterns and cellular markers such as neuropeptides and calcium-binding proteins. This molecular diversity has allowed generation of transgenic mouse strains in which GFP expression is linked to the expression of one of these markers and presumably a single subtype of

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2

Friend, Lindsey, Ryan Williamson, Collin Merrill, et al. "Hippocampal Stratum Oriens Somatostatin-Positive Cells Undergo CB1-Dependent Long-Term Potentiation and Express Endocannabinoid Biosynthetic Enzymes." Molecules 24, no. 7 (2019): 1306. http://dx.doi.org/10.3390/molecules24071306.

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The hippocampus is thought to encode information by altering synaptic strength via synaptic plasticity. Some forms of synaptic plasticity are induced by lipid-based endocannabinoid signaling molecules that act on cannabinoid receptors (CB1). Endocannabinoids modulate synaptic plasticity of hippocampal pyramidal cells and stratum radiatum interneurons; however, the role of endocannabinoids in mediating synaptic plasticity of stratum oriens interneurons is unclear. These feedback inhibitory interneurons exhibit presynaptic long-term potentiation (LTP), but the exact mechanism is not entirely und

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3

Zhang, C., X. Liu, and T.-F. Yuan. "Somatostatin-positive GABAergic interneuron: new targets for depression." Molecular Psychiatry 22, no. 6 (2017): 790–91. http://dx.doi.org/10.1038/mp.2017.11.

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Yekhlef, Latefa, Gian Luca Breschi, Laura Lagostena, Giovanni Russo, and Stefano Taverna. "Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex." Journal of Neurophysiology 113, no. 5 (2015): 1616–30. http://dx.doi.org/10.1152/jn.00841.2014.

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GABAergic interneurons are thought to play a critical role in eliciting interictal spikes (IICs) and triggering ictal discharges in temporal lobe epilepsy, yet the contribution of different interneuronal subtypes to seizure initiation is still largely unknown. Here we took advantage of optogenetic techniques combined with patch-clamp and field recordings to selectively stimulate parvalbumin (PV)- or somatostatin (SOM)-positive interneurons expressing channelrhodopsin-2 (CHR-2) in layers II–III of adult mouse medial entorhinal cortical slices during extracellular perfusion with the proconvulsiv

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5

Jang, Hyun Jae, Hyowon Chung, James M. Rowland, Blake A. Richards, Michael M. Kohl, and Jeehyun Kwag. "Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex." Science Advances 6, no. 17 (2020): eaay5333. http://dx.doi.org/10.1126/sciadv.aay5333.

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Synchronization of precise spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)– and somatostatin (SST)–positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of sp

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6

Shen, Wei, Ru Ba, Yan Su, et al. "Foxg1 Regulates the Postnatal Development of Cortical Interneurons." Cerebral Cortex 29, no. 4 (2018): 1547–60. http://dx.doi.org/10.1093/cercor/bhy051.

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AbstractAbnormalities in cortical interneurons are closely associated with neurological diseases. Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of Foxg1 in the cortical interneuron development. Here, by conditional deletion of Foxg1, which was achieved by crossing Foxg1fl/fl with the Gad2-CreER line, we found the postnatal distributions of somatostatin-, calretinin-, and neuropeptide Y-positive interneurons in the cortex were impaired. Further investigations revealed an enhanced dendritic complexity and decreased migration capacity of Foxg1-deficient interne

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7

Molgaard, Simon, Maj Ulrichsen, Simon Boggild, et al. "Immunohistochemical visualization of mouse interneuron subtypes." F1000Research 3 (October 13, 2014): 242. http://dx.doi.org/10.12688/f1000research.5349.1.

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The activity of excitatory neurons is controlled by a small, but highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different markers, morphology and their electrophysiological properties. Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA, but parvalbumin, calbindin, so

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8

Molgaard, Simon, Maj Ulrichsen, Simon Boggild, et al. "Immunofluorescent visualization of mouse interneuron subtypes." F1000Research 3 (November 20, 2014): 242. http://dx.doi.org/10.12688/f1000research.5349.2.

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The activity of excitatory neurons is controlled by a highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different markers, morphology and their electrophysiological properties. Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA, but parvalbumin, calbindin, somatostatin,

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9

Molgaard, Simon, Maj Ulrichsen, Simon Boggild, et al. "Immunofluorescent visualization of mouse interneuron subtypes." F1000Research 3 (June 4, 2015): 242. http://dx.doi.org/10.12688/f1000research.5349.3.

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The activity of excitatory neurons is controlled by a highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different markers, morphology and their electrophysiological properties. Ideally, all can be marked using an antibody directed against the inhibitory neurotransmitter GABA, but parvalbumin, calbindin, somatostatin,

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10

Fee, Corey, Mounira Banasr, and Etienne Sibille. "Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives." Biological Psychiatry 82, no. 8 (2017): 549–59. http://dx.doi.org/10.1016/j.biopsych.2017.05.024.

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11

Guet-McCreight, Alexandre, Frank Mazza, Thomas D. Prevot, Etienne Sibille та Etay Hay. "Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity". PLOS Computational Biology 20, № 12 (2024): e1012693. https://doi.org/10.1371/journal.pcbi.1012693.

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Treatment for major depressive disorder (depression) often has partial efficacy and a large portion of patients are treatment resistant. Recent studies implicate reduced somatostatin (SST) interneuron inhibition in depression, and new pharmacology boosting this inhibition via positive allosteric modulators of α5-GABAA receptors (α5-PAM) offers a promising effective treatment. However, testing the effect of α5-PAM on human brain activity is limited, meriting the use of detailed simulations. We utilized our previous detailed computational models of human depression microcircuits with reduced SST

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12

Novák, Ondřej, Ondřej Zelenka, Tomáš Hromádka, and Josef Syka. "Immediate manifestation of acoustic trauma in the auditory cortex is layer specific and cell type dependent." Journal of Neurophysiology 115, no. 4 (2016): 1860–74. http://dx.doi.org/10.1152/jn.00810.2015.

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Exposure to loud sounds damages the auditory periphery and induces maladaptive changes in central parts of the auditory system. Diminished peripheral afferentation and altered inhibition influence the processing of sounds in the auditory cortex. It is unclear, however, which types of inhibitory interneurons are affected by acoustic trauma. Here we used single-unit electrophysiological recording and two-photon calcium imaging in anesthetized mice to evaluate the effects of acute acoustic trauma (125 dB SPL, white noise, 5 min) on the response properties of neurons in the core auditory cortex. E

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13

Fatima, Mahar, Xiangyu Ren, Haili Pan, et al. "Spinal somatostatin-positive interneurons transmit chemical itch." PAIN 160, no. 5 (2019): 1166–74. http://dx.doi.org/10.1097/j.pain.0000000000001499.

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14

Ukai, *Wataru, Kenta Deriha, Emi Nishimura, et al. "THE RECOVERY EFFECT OF STEM CELLS AND KAMPO MEDICINE KAMIKIHITO ON SOCIAL BEHAVIOR DYSFUNCTIONS IN REFRACTORY PSYCHIATRIC DISORDERS." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i150—i151. https://doi.org/10.1093/ijnp/pyae059.259.

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Abstract Background The brain pathophysiology of social dysfunctions in depression and autism spectrum disorder are complex, and there is a growing need to understand the relevant neuronal circuit alterations and to find direct and effective treatments for their recoveries. Aims & Objectives In this study, we have investigated the influences of bone marrow-derived mesenchymal stem cell (MSC) transplantation and Japanese Kampo medicine, Kamikihito on social behaviors as a novel treatment options for intractable psychiatric disorders, using refractory depression animal model related to stres

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15

Zichó, Krisztián, Katalin E. Sos, Péter Papp, et al. "Fear memory recall involves hippocampal somatostatin interneurons." PLOS Biology 21, no. 6 (2023): e3002154. http://dx.doi.org/10.1371/journal.pbio.3002154.

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Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could

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16

Szőnyi, András, Katalin E. Sos, Rita Nyilas, et al. "Brainstem nucleus incertus controls contextual memory formation." Science 364, no. 6442 (2019): eaaw0445. http://dx.doi.org/10.1126/science.aaw0445.

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Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which inhibit pyramidal cells that are not required for memory formation. Here, we found that γ-aminobutyric acid (GABA)–releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic i

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17

Fuchs, T., S. J. Jefferson, A. Hooper, P.-H. P. Yee, J. Maguire, and B. Luscher. "Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors." Molecular Psychiatry 22, no. 6 (2017): 787. http://dx.doi.org/10.1038/mp.2017.110.

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Anastasiades, Paul G., Christina Boada, and Adam G. Carter. "Cell-Type-Specific D1 Dopamine Receptor Modulation of Projection Neurons and Interneurons in the Prefrontal Cortex." Cerebral Cortex 29, no. 7 (2018): 3224–42. http://dx.doi.org/10.1093/cercor/bhy299.

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Abstract Dopamine modulation in the prefrontal cortex (PFC) mediates diverse effects on neuronal physiology and function, but the expression of dopamine receptors at subpopulations of projection neurons and interneurons remains unresolved. Here, we examine D1 receptor expression and modulation at specific cell types and layers in the mouse prelimbic PFC. We first show that D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets including contralateral cortex, striatum, and claustrum rather than to extratelencephalic struct

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19

Seizer, Lennart, Sadegh Rahimi, Sandra Santos-Sierra, and Meinrad Drexel. "Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons." PLOS ONE 17, no. 5 (2022): e0267860. http://dx.doi.org/10.1371/journal.pone.0267860.

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Toll-like receptors (TLR) are one of the main constituents of the innate immune system in mammals. They can detect conserved microbial structures (pathogen-associated molecular patterns) and host-derived ligands that are produced during cellular stress and damage (danger-associated molecular patterns) and may then initiate an intracellular signaling cascade leading to the expression of pro-inflammatory cytokines and immediate immune responses. Some TLR (TLR1, 2, 4, 5, and 6) are expressed on the cell surface while others (TLR3, 7, 8 and 9) are present on the surface of endosomes and their liga

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20

Song, You-Hyang, Yang-Sun Hwang, Kwansoo Kim, et al. "Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1." Science Advances 6, no. 17 (2020): eaaz0517. http://dx.doi.org/10.1126/sciadv.aaz0517.

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Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST application in the primary visual cortex (V1) improves visual discrimination in freely moving mice and enhances orientation selectivity of V1 neurons. We also found that SST reduced excitatory synaptic transmission to parvalbumin-positive (PV+) fast-spiking interneurons but not to regular-spiking neurons. Last, using serial block-face scanning ele

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21

Vardya, Irina, Kim R. Drasbek, Zita Dósa, and Kimmo Jensen. "Cell Type–Specific GABAA Receptor–Mediated Tonic Inhibition in Mouse Neocortex." Journal of Neurophysiology 100, no. 1 (2008): 526–32. http://dx.doi.org/10.1152/jn.01224.2007.

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Activity of extrasynaptic GABAA receptors mediating tonic inhibition is thought to play an important role for the excitability of the mammalian cerebral cortex. However, little is known about the cell type–specific expression of tonic inhibition in particular types of cortical interneurons. Here, we used transgenic mice expressing green fluorescent protein (GFP) in somatostatin-positive (SOM) interneurons and investigated tonic inhibition in SOM interneurons versus pyramidal cells in neocortical layers 2/3. In brain slices, pyramidal cells showed a tonic current of 66 ± 19 pA in response to th

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22

Patrick, Saundra L., Barry W. Connors, and Carole E. Landisman. "Developmental changes in somatostatin-positive interneurons in a freeze-lesion model of epilepsy." Epilepsy Research 70, no. 2-3 (2006): 161–71. http://dx.doi.org/10.1016/j.eplepsyres.2006.04.001.

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Funk, Chadd M., Kayla Peelman, Michele Bellesi, William Marshall, Chiara Cirelli, and Giulio Tononi. "Role of Somatostatin-Positive Cortical Interneurons in the Generation of Sleep Slow Waves." Journal of Neuroscience 37, no. 38 (2017): 9132–48. http://dx.doi.org/10.1523/jneurosci.1303-17.2017.

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Angara, Kartik, Emily Ling-Lin Pai, Stephanie M. Bilinovich, et al. "Nf1deletion results in depletion of theLhx6transcription factor and a specific loss of parvalbumin+cortical interneurons." Proceedings of the National Academy of Sciences 117, no. 11 (2020): 6189–95. http://dx.doi.org/10.1073/pnas.1915458117.

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Neurofibromatosis 1 (NF1) is caused by mutations in theNF1gene, which encodes the protein, neurofibromin, an inhibitor of Ras activity. Cortical GABAergic interneurons (CINs) are implicated in NF1 pathology, but the cellular and molecular changes to CINs are unknown. We deleted mouseNf1from the medial ganglionic eminence, which gives rise to both oligodendrocytes and CINs that express somatostatin and parvalbumin.Nf1loss led to a persistence of immature oligodendrocytes that prevented later-generated oligodendrocytes from occupying the cortex. Moreover, molecular and cellular properties of par

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25

Zhang, Siyu, Min Xu, Tsukasa Kamigaki, et al. "Long-range and local circuits for top-down modulation of visual cortex processing." Science 345, no. 6197 (2014): 660–65. http://dx.doi.org/10.1126/science.1254126.

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Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid–ergic (GABAergic) circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation

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26

Sosulina, Ludmila, Stéphanie Graebenitz, and Hans-Christian Pape. "GABAergic Interneurons in the Mouse Lateral Amygdala: A Classification Study." Journal of Neurophysiology 104, no. 2 (2010): 617–26. http://dx.doi.org/10.1152/jn.00207.2010.

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Whole cell patch-clamp recordings were performed in GABAergic interneurons labeled by green fluorescent protein (GFP) in the lateral amygdala (LA) in vitro from glutamic acid decarboxylase 67 (GAD67)-GFP mice. Neurons were characterized by electrotonic and electrogenic parameters. Cytoplasm was collected from individual neurons, and single-cell RT-PCR was used for detection of molecular markers typifying LA interneurons. Hierarchical cluster and multiple discriminant analysis demonstrated the existence of five types of GABAergic interneurons, which can be reliably identified through electrophy

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27

Schmid, Lena C., Manuel Mittag, Stefanie Poll, et al. "Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer’s Disease Model." Neuron 92, no. 1 (2016): 114–25. http://dx.doi.org/10.1016/j.neuron.2016.08.034.

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Crowley, Nikki, Nigel Dao, and Dakota Brockway. "S212. The Role of Somatostatin Positive Interneurons in the Prelimbic Cortex in Alcohol Consumption." Biological Psychiatry 85, no. 10 (2019): S379. http://dx.doi.org/10.1016/j.biopsych.2019.03.963.

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Fuchs, T., S. J. Jefferson, A. Hooper, P.-HP Yee, J. Maguire, and B. Luscher. "Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state." Molecular Psychiatry 22, no. 6 (2016): 920–30. http://dx.doi.org/10.1038/mp.2016.188.

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Pombero, Ana, Raquel Garcia-Lopez, Emilio Geijo, and Salvador Martinez. "EFFECTS OF LIS1 MUTATION ON THE DEVELOPMENT OF SOMATOSTATIN-POSITIVE INTERNEURONS OF THE CINGULATE CORTEX." IBRO Neuroscience Reports 15 (October 2023): S127. http://dx.doi.org/10.1016/j.ibneur.2023.08.147.

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Song, You-Hyang, Jiwon Yoon, and Seung-Hee Lee. "The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders." Experimental & Molecular Medicine 53, no. 3 (2021): 328–38. http://dx.doi.org/10.1038/s12276-021-00580-4.

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AbstractSomatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein marker of inhibitory interneurons. Recent studies have identified the key functions of SST in modulating cortical circuits in the brain and cognitive function. Furthermore, reduced expression of SST is a hallmark of various neurological disorders, including Alzheimer’s disease and depression. In this review, we summarize the current knowledge on SST expression and function in the brain. In particular, we descr

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32

Kirchberger, Lisa, Sreedeep Mukherjee, Ulf H. Schnabel, et al. "The essential role of recurrent processing for figure-ground perception in mice." Science Advances 7, no. 27 (2021): eabe1833. http://dx.doi.org/10.1126/sciadv.abe1833.

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The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure-ground modulation (FGM) arises and whether it is necessary for perception. Here, we show, using optogenetic silencing in mice, that the delayed V1 response phase is necessary for figure-ground segregation. Neurons in higher visual areas also exhibit FGM and optogenetic silencing of higher areas reduced FGM in V1. In V1, figures elicited higher activ

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Uchida, Katsuya, Yusuke Taguchi, Chika Sato, et al. "Amelioration of improper differentiation of somatostatin-positive interneurons by triiodothyronine in a growth-retarded hypothyroid mouse strain." Neuroscience Letters 559 (January 2014): 111–16. http://dx.doi.org/10.1016/j.neulet.2013.11.052.

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Gibson, J. R., K. M. Huber, and T. C. Sudhof. "Neuroligin-2 Deletion Selectively Decreases Inhibitory Synaptic Transmission Originating from Fast-Spiking but Not from Somatostatin-Positive Interneurons." Journal of Neuroscience 29, no. 44 (2009): 13883–97. http://dx.doi.org/10.1523/jneurosci.2457-09.2009.

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Crowley, Nikki, and Bernhard Luscher. "Assessing the contribution of somatostatin-positive interneurons in the drinking in the dark binge-like ethanol consumption model." Alcohol 60 (May 2017): 239. http://dx.doi.org/10.1016/j.alcohol.2017.02.337.

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Ayoub, George S., and Gary Matthews. "Substance P modulates calcium current in retinal bipolar neurons." Visual Neuroscience 8, no. 6 (1992): 539–44. http://dx.doi.org/10.1017/s0952523800005630.

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AbstractRetinal bipolar cells are non-spiking interneurons that relay information from photoreceptors to amacrine and ganglion cells. In turn, bipolar cells receive extensive synaptic feedback from amacrine cells, some of which contain neuropeptides, including substance P. We have examined the effect of substance P on single bipolar neurons isolated from goldfish retina and find that substance P (0.1–1 nM) produced a voltage-dependent inhibition of calcium current in these cells. The inhibition was strongest at negative potentials, with the peak suppression occurring at –20 to –30 mV; at poten

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37

Yang, Xiao-Yu, Zhao-Liang Ma, Daniel R. Storm, Hong Cao, and Yu-Qiu Zhang. "Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice." World Journal of Psychiatry 11, no. 2 (2021): 21–35. http://dx.doi.org/10.5498/wjp.v11.i2.21.

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Yang, Xiao-Yu, Zhao-Liang Ma, Daniel R. Storm, Hong Cao, and Yu-Qiu Zhang. "Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice." World Journal of Psychiatry 11, no. 2 (2021): 35–49. http://dx.doi.org/10.5498/wjp.v11.i2.35.

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Zacharko-Siembida, Anna, Małgorzata Matysek, Radosław Szalak, and Marcin B. Arciszewski. "An Immunohistochemical Study of Cocaine- and Amphetamine-Regulated Transcript (Cart) Expression in the Pterygopalatine Ganglion of the Pig." Acta Veterinaria 67, no. 3 (2017): 397–408. http://dx.doi.org/10.1515/acve-2017-0032.

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AbstractAlthough, a great effort has been made to understand the synthesis, regulation, processing and function of cocaine- and amphetamine-regulated transcript (CART) peptide at the central level, its peripheral function(s) are still obscure. Moreover, scarce studies describing the presence of CART in peripheral autonomic ganglia are mainly limited to laboratory rodents. Thus, the aim of the present study was to immunohistochemically investigate the expression of CART in Hu C/D-positive neurons of the porcine pterygopalatine ganglion (PPG). The distribution pattern of CART-IR nerve elements i

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40

Niethard, Niels, Hong-Viet V. Ngo, Ingrid Ehrlich, and Jan Born. "Cortical circuit activity underlying sleep slow oscillations and spindles." Proceedings of the National Academy of Sciences 115, no. 39 (2018): E9220—E9229. http://dx.doi.org/10.1073/pnas.1805517115.

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Slow oscillations and sleep spindles are hallmarks of the EEG during slow-wave sleep (SWS). Both oscillatory events, especially when co-occurring in the constellation of spindles nesting in the slow oscillation upstate, are considered to support memory formation and underlying synaptic plasticity. The regulatory mechanisms of this function at the circuit level are poorly understood. Here, using two-photon imaging in mice, we relate EEG-recorded slow oscillations and spindles to calcium signals recorded from the soma of cortical putative pyramidal-like (Pyr) cells and neighboring parvalbumin-po

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Santos-Terra, Júlio, Iohanna Deckmann, Giovanna Carello-Collar, et al. "Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism." International Journal of Molecular Sciences 23, no. 8 (2022): 4075. http://dx.doi.org/10.3390/ijms23084075.

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Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by several alterations, including disorganized brain cytoarchitecture and excitatory/inhibitory (E/I) imbalance. We aimed to analyze aspects associated with the inhibitory components in ASD, using bioinformatics to develop notions about embryonic life and tissue analysis for postnatal life. We analyzed microarray and RNAseq datasets of embryos from different ASD models, demonstrating that regions involved in neuronal development are affected. We evaluated the effect of prenatal treatment with resveratrol (R

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Park, Kyerl, Hyowon Chung, Hyun Jae Jang, Michael Kohl та Jeehyun Kwag. "Dissociation of parvalbumin-positive and somatostatin-positive interneurons’ contributions to frequency-selective impairments of synaptic inhibition to hippocampal pyramidal cells induced by Aβ oligomers in vitro". IBRO Reports 6 (вересень 2019): S123. http://dx.doi.org/10.1016/j.ibror.2019.07.392.

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Wang, Alice Y., Kathryn M. Lohmann, C. Kevin Yang, et al. "Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region." Acta Neuropathologica 122, no. 5 (2011): 615–26. http://dx.doi.org/10.1007/s00401-011-0881-4.

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Göngrich, Christina, Favio A. Krapacher, Hermany Munguba, et al. "ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons." Journal of Cell Biology 219, no. 1 (2019). http://dx.doi.org/10.1083/jcb.201905002.

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Although the role of transcription factors in fate specification of cortical interneurons is well established, how these interact with extracellular signals to regulate interneuron development is poorly understood. Here we show that the activin receptor ALK4 is a key regulator of the specification of somatostatin interneurons. Mice lacking ALK4 in GABAergic neurons of the medial ganglionic eminence (MGE) showed marked deficits in distinct subpopulations of somatostatin interneurons from early postnatal stages of cortical development. Specific losses were observed among distinct subtypes of som

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Rallapalle, Vyshnavi, Annesha C. King, and Michelle Gray. "BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington’s Disease." Frontiers in Neuroanatomy 15 (May 24, 2021). http://dx.doi.org/10.3389/fnana.2021.673177.

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Huntington’s disease (HD) is a dominantly inherited, adult-onset neurodegenerative disease characterized by motor, psychiatric, and cognitive abnormalities. Neurodegeneration is prominently observed in the striatum where GABAergic medium spiny neurons (MSN) are the most affected neuronal population. Interestingly, recent reports of pathological changes in HD patient striatal tissue have identified a significant reduction in the number of parvalbumin-expressing interneurons which becomes more robust in tissues of higher disease grade. Analysis of other interneuron populations, including somatos

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Reid, Hannah M. O., Owen Trepanier, Allyson Gross, et al. "Prenatal ethanol and cannabis exposure have sex‐ and region‐specific effects on somatostatin and neuropeptide Y interneurons in the rat hippocampus." Alcohol, Clinical and Experimental Research, May 24, 2024. http://dx.doi.org/10.1111/acer.15350.

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AbstractBackgroundCannabis is increasingly being legalized and socially accepted around the world and is often used with alcohol in social settings. We recently showed that in utero exposure to both substances can alter the density of parvalbumin‐expressing interneurons in the hippocampus. Here we investigate the effects of in utero alcohol and cannabis exposure, alone or in combination, on somatostatin‐ and neuropeptide Y‐positive (NPY) interneurons. These are separate classes of interneurons important for network synchrony and inhibition in the hippocampus.MethodsA 2 (Ethanol, Air) × 2 (tetr

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McGarry. "Quantitative classification of somatostatin-positive neocortical interneurons identifies three interneuron subtypes." Frontiers in Neural Circuits, 2010. http://dx.doi.org/10.3389/fncir.2010.00012.

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Zucca, Stefano, Giulia D'Urso, Valentina Pasquale, et al. "An inhibitory gate for state transition in cortex." eLife, May 16, 2017. https://doi.org/10.7554/eLife.26177.

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Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state tran

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Shen, Kaiyuan, Yandong Zhang, Yunyun Huang, Yunli Xie, Jing Ding, and Xin Wang. "Prenatal Valproic Acid Exposure Impairs Offspring Cognition Through Disturbing Interneuron Development." CNS Neuroscience & Therapeutics 31, no. 2 (2025). https://doi.org/10.1111/cns.70303.

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ABSTRACTAimsValproic acid (VPA) exposure during the gestational period has been found to impair the cognition of the offspring. The study aimed to investigate whether VPA leads to offspring cognitive impairment through disturbing interneuron development.MethodsPregnant mice were injected with VPA peritoneally to establish the prenatal VPA exposure model. Cortical interneurons were labeled with Rosa26‐EYFP/− reporter mice activated by Nkx2.1‐Cre. Interneuron subtypes both in the cortex and the hippocampus were detected by immunofluorescence. A battery of behavioral tests was conducted on postna

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Voelkl, Kerstin, Elena Katharina Schulz-Trieglaff, Rüdiger Klein, and Irina Dudanova. "Distinct histological alterations of cortical interneuron types in mouse models of Huntington’s disease." Frontiers in Neuroscience 16 (September 26, 2022). http://dx.doi.org/10.3389/fnins.2022.1022251.

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Huntington’s disease (HD) is a debilitating hereditary motor disorder caused by an expansion of the CAG triplet repeat in the Huntingtin gene. HD causes neurodegeneration particularly in the basal ganglia and neocortex. In the cortex, glutamatergic pyramidal neurons are known to be severely affected by the disease, but the involvement of GABAergic interneurons remains unclear. Here, we use a combination of immunostaining and genetic tracing to investigate histological changes in three major cortical interneuron types — parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VI

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