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Rozprawy doktorskie na temat „Somnifera”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Raghavan, Aparna. "Neuroprotective Potential of Withania Somnifera in Cerebral Ischemia." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1416570371.

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Kumar, S. R. J. "Molecular studies on glycosyltransferase gene (s) from withania somnifera." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2011. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3806.

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Kulkarni, A. A. "Micropropagation and secondary metabolite studies in taxus spp. and withania somnifera(L.) dunal." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2000. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2286.

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Gupta, N. "Molecular studies on withanolides biosynthetic pathway gene (s) (squalene synthase) from withania somnifera." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2211.

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Teixeira, Silvia Torres. "Avaliação do extrato da Withania somnifera na resposta hematopoetica de camundongos infectados com Listeria monocytogenes." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311288.

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Orientador: Mary Luci de Souza Queiroz<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T02:14:58Z (GMT). No. of bitstreams: 1 Teixeira_SilviaTorres_M.pdf: 4055916 bytes, checksum: baff4036eb508a4117b2506e0204d392 (MD5) Previous issue date: 2004<br>Resumo: A Withania somnifera (WS) é uma planta popularmente conhecida na medicina hindu pela sua potente capacidade de reforçar a saúde e prevenir doenças. Diversas investigações científicas têm atribuído essa qualidade ao potencial adaptógeno das suas raízes, que

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Chandrasekaran, Sambamurthy, Jalaja Veronica, Shyam Sundar, and Radheshyam Maurya. "Alcoholic Fractions F5 and F6 from Withania somnifera Leaves Show a Potent Antileishmanial and Immunomodulatory Activities to Control Experimental Visceral Leishmaniasis." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/625511.

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Visceral leishmaniasis (VL) causes fatal life-threatening disease, if left untreated. The current drugs have various limitations; hence, natural products from medicinal plants are being focused in search of new drugs to treat leishmaniasis. The aim of the present study was to evaluate the antileishmanial and immunomodulatory activities of F5 and F6 alcoholic fractions from Withania somnifera leaves and purified withaferin-A in Leishmania donovani-infected peritoneal macrophages and BALB/c mice. We observed that F5 (15 mu g/mL), F6 (10 mu g/mL), and withaferin-A (1.5 mu M) reduce amastigote cou

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7

Melo, Adriana de. "Estudo da atividade imunomoduladora do extrato bruto de Withania somnifera em camundongos portadores do tumor ascitico de Ehrlich." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313443.

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Orientadores: Mary Luci de Souza Queiroz<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-03T23:28:36Z (GMT). No. of bitstreams: 1 Melo_Adrianade_D.pdf: 659613 bytes, checksum: 7fad6c2766a54d3e79d1362ad24ec460 (MD5) Previous issue date: 2004<br>Resumo: O câncer é uma das doenças mais prevalentes no Brasil e no mundo. Atualmente, a radioterapia e a quimioterapia são utilizadas como tratamento de primeira escolha para esta doença e caracterizam-se por não possuir toxicidade seletiva, causando sérios efeitos adversos c

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8

ANZANI, NICOLA. "Secondary Metabolites from Otanthus maritimus, Stachys glutinosa and Withania somnifera: Isolation, Structure Elucidation and Interactions with Cannabinoid and Opioid Systems." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266436.

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In our continuous search for plant secondary metabolites that bind to CB and/or opioid receptors, we selected four extracts that showed interesting affinity versus the above mentioned receptors . In particular: the DCM extract obtained from the aerial parts of Stachys glutinosa (SGE) was able to bind with a good affinity both MOR and DOR with a Ki of 10.3 and 9 μg/mL, respectively while the DCM extract from the leaves of Otanthus maritimus (OME) showed good binding affinity to CB1 (Ki = 2.2 μg/mL) and CB2 (Ki = 1.3 μg/mL) and moderate affinity to MOR and DOR. The third was an alkaloid fraction

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9

Mekbib, SB Regnier Thierry J. C. Sivakumar Dharini Korsten Lise, TJC Regnier, D. Sivakumar, and L. Korsten. "Evaluation of Ethiopian plant extracts, Acacia seyal and Withania somnifera, to control green mould and ensure quality maintenance of citrus (Citrus sinensis L.)." Cirad/EDP Sciences, 2009. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001695.

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Abstract Introduction. Green mould, Penicillium digitatum (Pers.: Fr.) Sacc., causes economically important postharvest disease in citrus. Materials and methods. Ethiopian plant extracts of Acacia seyal (Del. Var. Seyal) and Withania somnifera (L.) Dual were used to test the control of green mould in wound-inoculated fruit, stored for 21 d at 7 °C and at > 85% RH. The chemical compositions of the two extracts were determined using high-performance chromatography. Thereafter, freshly harvested (naturally infected) fruit were subjected to different postharvest treatments and stored for 50 d to

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10

Elleuch, Habib. "Clonage du gène sam-1 d'Arabidopsis thaliana sous contrôle du promoteur inductible salt du riz : Expression et inactivation du transgène chez les lignées cellulaires de pavot." Compiègne, 1997. http://www.theses.fr/1997COMP1054.

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La plante de pavot (Papaver somniferum) est connue pour la production d'alcaloïdes morphiniques (codéine et morphine). Les cultures de cellules indifférenciées ne produisent pas de tels alcaloïdes. Dans l'espoir d'induire la production de ces métabolites chez les suspensions cellulaires nous avons réalisé le clonage du gène sam1 d'Arabidopsis thaliana sous le contrôle du promoteur sa/T du riz, inductible par un stress osmotique ou par application d'ABA. Quatre constructions de vecteurs binaires ont été réalisées, différant entre elles par la séquence du promoteur régulant l'expression du gène

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11

Fadl, Almoulah Nahla. "Études phytochimique et biologique de cinq plantes de la famille des Solanaceae." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0184/document.

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Ce travail de recherche a pour objectifs d’évaluer les activités antibactériennes, antiprolifératives et antioxydantes des extraits de feuilles de Solanum incanum L., S. schimperianum Hochst, S. nigrum L., Physalis lagascae Roem. & Schult. et Withania somnifera (L) Dunal. Plus précisément, les activités antibactériennes, anti-prolifératives et antioxydantes ont été déterminées à partir des extraits méthanoliques et des fractions de glycoalcaloïdes stéroïdiens (SGAF) de chaque plante. La sensibilité des bactéries, à Gram positif et à Gram négatif, était variable en présence de chacun des ex

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12

DE, ROSE FRANCESCAELENA. "Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266643.

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Drosophila melanogaster (Dm) is a valuable genetic model for exploring molecular, genetic and cellular aspects of neurodegeneration in Parkinson's disease (PD), for further understanding its etiology and pathogenesis and making valid contributions to drug screening. This study used two loss-of-function Dm mutants, PINK1B9 and LRRK2WD40 (deletion of WD40 domain), that both express essential phenotypic characteristics of PD in humans, albeit with a different biochemical mechanism and pathways. Since therapeutic treatments to limit the onset of PD are not yet available and the common approach to

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13

MACCIONI, RICCARDO. "Phytomedicinal approach toward the treatment of CNS disorders: behavioural and biochemical evaluation of the effects of a methanolic dry root extract of Withania somnifera and its isolated metabolite, Docosanyl Ferulate, in rodent models of anxiety and drug addiction." Doctoral thesis, Università degli Studi di Cagliari, 2022. http://hdl.handle.net/11584/332548.

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The use of phytomedicinal remedies has increased during the last decades thanks to the relative low cost, low toxicity, and potential synergic effects of plant-derived medications. Withania somnifera (WS), commonly known as Indian Ginseng, is a medical plant belonging to the Indian Traditional Medical System, the Ayurveda. In preclinical studies, WS has shown an impressive variety of therapeutic effects in several pathological conditions. Among these effects, the anxiolytic and antiaddictive properties of this plant are the ones discussed in this work of thesis. Both effects have been attribu

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14

Meade, Fergus. "Biosynthetic regulation of the major opiates of Papaver somniferum." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/11992/.

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Opium poppy, Papaver somniferum, is the sole source of the analgesic alkaloids morphine and codeine as well as thebaine, a precursor for semi-synthetic opiates. T6ODM (thebaine 6-O-demethylase) and CODM (codeine O-demethylase) are dioxygenases involved in morphine biosynthesis and represent promising targets for metabolic engineering of the morphinan alkaloid pathway through reverse genetic screening. An EMS (ethyl methanesulfonate)-mutagenised population of a morphine accumulating cultivar (>4000 plants) was screened for mutations in CODM and T6ODM. Although nonsense mutations were found in b

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15

Weid, Marion. "Gewebe- und zellspezifische Lokalisation der Alkaloidbiosynthese in Papaver somniferum L." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=975600575.

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16

Míča, Luděk. "Analýza vlivu odrůd a ošetření osiva na vybrané parametry semen máku setého (Papaver somniferum L.)." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-259771.

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Czech Republic is one of the world's leading producers of the poppy seeds. Concerning the growing field area of poppy, the Czech Republic is lead producer of the poppy seeds at the international level (Vašák, 2010; Cihlář, 2012). Poppy seed is very sensitive on many internal and external factors during cultivation, especially in the beginning of germination and emergence. At present, there are not registered preparations available for seed dressing for poppy seed in the Czech Republic (Prokinová, 2006). However, there has been done many experiments based on testing of natural substances (eg. h

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17

Day, Keith B. "Papaver somniferum and P. bracteatum : tissue culture and morphinan alkaloid production." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35449.

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Papaver somniferum plants accumulate the secondary products codeine and morphine. P. bracteatum accumulates their precursor, thebaine. The aims of the project were to use tissue cultures for the production of these alkaloids and for the biotransformation of thebaine to codeine and morphine. Methods were evaluated for the extraction, separation and quantification of mg or mug amounts of morphinan alkaloids from plant material. TLC, IIPLC and RIA were useful. Poppy cells fron a range of seed sources and explants were grown in static and suspension culture. Manipulations were made in atterpts to

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18

Raymond, Michelle Jean. "Isolation and characterization of latex-specific promoters from Papaver somniferum L." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/34869.

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The pharmacologically important alkaloids morphine and codeine are found in latex of opium poppy (Papaver somniferum). Latex is harbored in laticifers, a specialized vascular cell-type. Isolation and characterization of latex-specific genes may provide a useful tool to metabolically engineer increased alkaloid production. Previous research in the Nessler laboratory identified genes that exhibit latex-specific gene expression. Latex-specific genes were an 2-oxoglutarate-dioxygense (DIOX), involved in hydroxylation, desaturation and epoxidation reactions, and two of the major latex proteins,

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19

Cabry, Marc P. "Structural analysis of a Papaver somniferum O-methyltransferase involved in noscapine biosynthesis." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19988/.

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Slowiaczek, Lukáš. "Tvorba výnosu a sušiny u genetických zdrojů máku setého (Papaver somniferum L.)." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-259766.

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Diploma thesis with the topic: Formation of yield and dry matter with genetic resources of opium poppy (Papaver somniferum L.) was worked out at the Department of botanics and plant physiology, Faculty of agrobiology, food and natural resources ČZU in Prague. The purpose of this thesis was to determine genotype and ontogenetic differences in amount of yield, production of dry mass, and value of growth-analytic characteristics in certain species of opium poppy. Diploma thesis was based on the fact that most of the studies about opium poppy (Papaver somniferum L.) are focused on the content of a

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Lainer, Johanna [Verfasser]. "Molekular-sensorische Charakterisierung des bitteren Fehlgeschmacks in Mohnsamen (Papaver Somniferum L.) / Johanna Lainer." München : Verlag Dr. Hut, 2019. http://d-nb.info/1192568168/34.

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Ninan, Aleyamma. "The extraction and chemistry of the metabolites of Mimosa tenuiflora and Papaver somniferum." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760609.

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BELNY, MURIEL. "La transformation de suspensions cellulaires de papaver somniferum par agrobacterium tumefaciens avec le gene sam1 d'arabidopsis thaliana codant pour la sam synthetase." Amiens, 1995. http://www.theses.fr/1995AMIEP051.

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Goy, Julian Graham. "Studies on the biotransformation of codeinone to codeine by cell cultures of Papaver somniferum." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/12050.

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The aim of this project was to examine the process by which cultured cells of <i>Papaver somniferum</i> and related species, biotransform codeinone to codeine. It was confirmed in this study that plants of <i>P.somniferum</i> produce the morphinan alkaloids thebaine, codeine and morphine and therefore, possess the enzyme involved in the biotransformation of codeinone to codeine. However plants of <i>P.bracteatum</i> and <i>P.orientale</i> only accumulate thebaine apparently lacking one or more of the enzymes necessary to convert thebaine to morphine. Suspension cultures derived from <i>P.somni

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Gerardi, Richard David, and mikewood@deakin edu au. "Investigations into the analytical applications and fundamental chemistry of the chemiluminescent reactions of Tris(22-bipyridyl)ruthenium(III) with certain Papaver Somniferum alkaloids and other related compounds." Deakin University. School of Biological and Chemical Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20060630.100432.

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The reaction of tris(2,2-bipyridyl)ruthenium(III) (Ru(bipy) <sub>3</sub><sup>3+</sup>) with various analytes to generate chemiluminescence has been well documented. This investigation sought to undertake a chemiluminometic study of the reactions of Ru(bipy) <sub>3</sub><sup>3+</sup> with selected Papaver Somniferum alkaloids and specifically synthesised phenethylamines. The investigation, based on a kinetic study, primarily addressed the effect of varying reaction conditions (pH) on Ru(bipy) <sub>3</sub><sup>3+</sup> chemiluminescence production. To monitor these reactions, a batch chemilu

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26

Hrušková, Jana. "Vliv aplikace minerálních hnojiv před setím se zapravením sečkou na výnos máku (Papaver somniferum L.)." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-258000.

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Poppy (Papaver somniferum L.) is plant which is in Czech Republic cultivated and consumed for a long time. Czech Republic was the biggest producer of poppy seeds in the world. It is not true currently but Czech Republic is still one of the most important producers of poppy. Czech growers produce high quality poppy seeds but they had several problems during last years. For example fluctuation of price of poppy and bad weather condition. Those problems influenced crop. Those complications caused that growers of poppy try to have stable yields for good profit. Yield parameters, such as amount and

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Montane, Marie-Hélène. "Approche biophysicochimique de la transformation directe de protoplastes végétaux par des champs électriques pulsés : cas du tabac." Toulouse, INPT, 1989. http://www.theses.fr/1989INPT024A.

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Les champs electriques pulses qui permettent de declencher la fusion cellulaire et le transfert direct d'adn purifie dans des protoplastes est apte a un controle systematique des parametres. Le role des parametres electriques et biologiques est analyse a partir des caracteristiques electriques associees a quatre evenements induits par l'application d'impulsions permeabilisantes: fuite d'atp, incorporation de colorants, modulation de la division et letalite. Une specificite des protoplastes vegetaux est imposee par la presence d'un organite typiquement vegetal: la vacuole. Une deuxieme particul

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Luhmer, Katharina [Verfasser]. "Anbauoptimierung durch Mischanbau und inhaltsstoffliche sowie sensorische Qualitätseigenschaften morphinarmer Winter- und Sommermohnsorten (Papaver somniferum L.) / Katharina Luhmer." Bonn : Universitäts- und Landesbibliothek Bonn, 2021. http://d-nb.info/1234550466/34.

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Schöllhorn, Claudia. "I. Strukturchemische und immunologische Untersuchungen von Polysacchariden Withania somnifers (L.) Dunal. II. Untersuchungen zur Struktur-Wirkungs-Beziehung von Polysacchariden aus Echinacea purpurea-Zellsuspensionskulturen /." [S.l. : s.n.], 1994. http://www.gbv.de/dms/bs/toc/164249532.pdf.

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Pienkny, Silke [Verfasser], Wolfgang [Akademischer Betreuer] Brandt, Milton [Akademischer Betreuer] Stubbs, and Ulrike [Akademischer Betreuer] Holzgrabe. "Identifizierung und Charakterisierung einer neuen O-Methyltransferase aus Papaver somniferum / Silke Pienkny. Betreuer: Wolfgang Brandt ; Milton Stubbs ; Ulrike Holzgrabe." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, Halle, Hochschulschriften, 2011. http://d-nb.info/1025506944/34.

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Gevenkiris, Ali. "Determination Of Morphine And Total Phenolic Content In Poppy Seed Of Turkish Origin." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613052/index.pdf.

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Turkey is important major licid opium poppy (Papaver Somniferum) producer for medicinal and scientific purposes in the world and one of the two traditional producer country. The poppy seeds which are unique part of the opium poppy are used for food purpose. About 25.000 ton/year poppy seeds were produced for food purpose. Recent years morphine content of commercially available poppy seeds were speculated. Some studies have been reported that poppy seeds from different origins contain a wide variation of morphine (2 &ndash<br>294) &mu<br>g/g content. They have been used also different sample pr

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Lerchner, Alexandra. "Studien zur Gewinnung und gentechnischen Modifizierung von Phospholipase D aus Schlafmohn (Papaver somniferum L.) und Weisskohl (Brassica oleracea var. capitata)." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975652311.

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Le, Flem-Bonhomme Valérie. "Transformation génétique de plantes médicinales : Atropa belladonna et Papaver somniferum var. album par les gènes rol : impact sur le métabolisme alcaloi͏̈dique." Amiens, 2002. http://www.theses.fr/2002AMIED001.

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Dittbrenner, Anke [Verfasser], A. [Akademischer Betreuer] Börner, M. [Akademischer Betreuer] Röser, and J. W. [Akademischer Betreuer] Kadereit. "Morphologische, phytochemische und molekulare Untersuchungen zur intraspezifischen Diversität von Schlafmohn (Papaver somniferum L.) / Anke Dittbrenner. Betreuer: A. Börner ; M. Röser ; J. W. Kadereit." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2009. http://d-nb.info/1024874176/34.

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DUBEDOUT, MARTINE. "Analyse de descendances provenant d'un plan circulaire de croisements chez le pavot (papaver somniferum l. ). Variabilite revelee au sein d'hybrides triples, de leurs descendances autofecondees et d'haploides doubles." Paris 11, 1993. http://www.theses.fr/1993PA112482.

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Ce travail a ete entrepris dans le cadre d'un programme d'amelioration d'une population de pavot illette pour la creation varietale. Selon le principe d'une selection recurrente, un plan de croisements a ete mis en place, suivi d'une phase d'evaluation des meilleurs descendants issus de ce brassage. Ceux-ci constitueront les parents du plan de croisements suivant. L'ensemble des resultats est un bilan du premier cycle d'intercroisements. La population parentale, a base genetique large, est composee pour moitie de varietes performantes sous nos climats et pour moitie de cultivars exotiques. L'e

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Connerade, Florent. "L'opium dans les sociétés britannique et indienne au dix-neuvième siècle." Toulouse 2, 2002. http://www.theses.fr/2002TOU20044.

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Après un bref récapitulatif des données historiques et scientifiques sur les stupéfiants, et plus particulièrement le Papaver somniferum et ses dérivés, cette thèse propose une étude exhaustive du rôle de l'opium et de ses dérivés dans les sociétés britanniques et indienne du dix-neuvième siècle. La première partie retrace l'histoire de la paviculture en Grande-Bretagne et décrit les circuits de commercialisation de l'opium d'importation, depuis ses aires de production en Asie Mineure jusqu'au consommateur final. Puis, cette thèse analyse les conséquences de l'utilisation croissante d'opiaciés

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Sagan, Sandrine. "Du pavot (pepaver somniferum) a la grenouille : utilisation des peptides opioides de la peau d'amphibien, dermorphine, dermenkephaline et deltorphine i, pour l'etude des mecanismes de reconnaissance des recepteur opioides mu et delta." Paris 6, 1991. http://www.theses.fr/1991PA066627.

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La peau d'amphibien represente une source formidable de peptides biologiquement actifs qui, pour un certain nombre, se retrouvent sous forme identique ou voisine dans le systeme nerveux central et le tractus gastro-intestinal des mammiferes. Ces peptides de la peau d'amphibien ont ainsi permis d'isoler de nouveaux peptides chez les mammiferes, ou d'en preciser les mecanismes de biosynthese et d'action. Dans ce cadre, les peptides opioides de la peau des rainettes phyllamedusae ont permis d'obtenir de nouvelles informations sur les mecanismes de reconnaissance mis en jeu par les recepteurs opio

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Le, Failler Philippe. "Le Mouvement international anti-opium et l'Indochine, 1906-1940." Aix-Marseille 1, 1993. http://www.theses.fr/1993AIX10046.

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Etude historique retracant sur l'ensemble de l'extreme-orient l'evolution du concept opium marchandise a celui de drogue au sens moderne du terme. L'emergence du mouvement international anti-opium y est etudie dans ses consequences politiques,diplomatiques et sociales sur l'ensemble de l'aire geographique. L'indochine sous administration francaise y est l'exemple d'une economie coloniale dependant de cette evolution conceptuelle retracee par les ambiguites de sa politique fiscale face a l'evolution des mentalites et a l'emergence du concept de sante publique<br>A historical study focusing ont

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Pillay, Nickita Nikki. "A Homoeopathic C4 trituration proving of Withania somnifera with a subsequent comparison to the conventional 30CH proving of Withania somnifera." Thesis, 2017. http://hdl.handle.net/10321/2916.

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Submitted in partial compliance with the requirements of the Master’s Degree in Technology: Homoeopathy, Durban University of Technology, Durban, South Africa, 2017.<br>The C4 trituration method is a unique method for homoeopathically proving a substance and determining its therapeutic properties. The process requires the use of a mortar and pestle and involves many rounds of grinding (triturating) the raw substance. During the trituration process symptoms are experienced by the triturator. Withania somnifera, commonly known as Ashwagandha in Ayurvedic medicine is highly regarded for its c

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Laidlaw, Marisa. "A homoeopathic drug proving of Withania somnifera 30CH." Thesis, 2016. http://hdl.handle.net/10321/1515.

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Submitted in fulfillment of the requirements for the degree of Master of Technology : Homeopathy, Durban University of Technology, Durban, South Africa, 2016.<br>Introduction The purpose of this study was to conduct a homoeopathic proving of Withania somnifera in the thirtieth centesimal potency [30CH], thereafter to determine and report the symptomatology in standard materia medica and repertory format, and then compare this symptomatology to the indigenous African and Ayurvedic medicinal usage of Withania somnifera. Methodology The homoeopathic drug proving of Withania somnifera 30CH was

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Marslin, Gregory. "Nanotechnological approaches using curcumin and Withania somnifera: neuroprotection and antimicrobial activities." Doctoral thesis, 2015. http://hdl.handle.net/1822/40423.

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Tese de Doutoramento em Biologia de Plantas<br>Neurological disorders contribute to 6.3% of the global burden of the diseases and this number is increasing every year due to aging population. Despite enormous efforts in brain and central nervous system related research, neurodegenerative diseases such as Alzheimer or Parkinson disease remain the world's leading cause of disability. Moreover, neurodegenerative diseases are multifactorial pathogenesis with a complex combination of genetic components and environmental factors. Although, several treatment methods are available to treat these

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Pinto, Inês Almeida. "In vitro and in vivo bioactivity evaluation of an Withania somnifera ethanolic extract." Master's thesis, 2017. http://hdl.handle.net/1822/47185.

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Dissertação de mestrado em Biologia Molecular, Biotecnologia e Bioempreendedorismo em Plantas<br>On recent years, an exponential increase in recognition of the therapeutic potential of various plant species has led to its applicability in the treatment of multiple neurodegenerative diseases. Withania somnifera (WS) is a multifunctional herb that has promising effects on the neurological system with capable antioxidant properties. Zebrafish (Danio rerio, Hamilton 1822) embryo toxicity (ZET) protocol has been predominantly used as an in vivo model to evaluate the potential toxic effects upo

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Venter, Claire Lynne. "The antioxidant and cellular effects of Withania somnifera alone and in combination with selenium." Diss., 2013. http://hdl.handle.net/2263/33161.

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The respiratory system is a target for environmental oxidants from airborne pollution and other contaminants. Chronic exposure may result in inflammatory conditions such as allergies and asthma. The ability of the body to counteract oxidation is dependent on the oxidative status of the individual, and can also benefit from the use of medicinal plant preparations such as Withania somnifera (WS), which is accredited with antioxidant and antiinflammatory properties. Selenium is an important cofactor of antioxidant enzymes such as glutathione peroxidase. A deficiency of Se will result in dec

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Krishnayya, Mridula. "Investigations on the behavioural effects of indigeneous plant medicine aswagandha (withania somnifera) on albino rats." Thesis, 1992. http://hdl.handle.net/2009/2718.

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Oberholzer, Hester Magdalena. "Investigating the effect of Withania somnifera on coagulation, blood count and bronchial lavage of Balb/c mice." 2008. http://upetd.up.ac.za/thesis/available/etd-08122008-090724.

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Motara, Farhad Essop. "Determination of the antimicrobial properties of Withania somnifera and Xysmalobium undulatum plant tinctures in terms of the disc diffusion assay and the agar dilution sensitivity test." Thesis, 2007. http://hdl.handle.net/10321/326.

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Thesis (M.Tech.: Homoeopathy) - Dept. of Homoeopathy, Durban Institute of Technology, 2003 xviii, 122 leaves<br>This study was designed to investigate the antimicrobial efficacy of Withania somnifera and Xysmalobium undulatum plant tinctures in 62% ethanol in inhibiting the in vitro growth of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.

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"Estudo da atividade imunomoduladora do extrato bruto de Withania somnifera em camundongos portadores do tumor ascitico de Ehrlich." Tese, Biblioteca Digital da Unicamp, 2021. http://libdigi.unicamp.br/document/?code=vtls000330619.

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Grover, Abhinav. "Studies on withanolides from Withania somnifera : in silico elucidation of their action mechanisms and engineering of their biosynthetic pathway." Thesis, 2011. http://localhost:8080/xmlui/handle/12345678/2782.

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Liebmann, André. "Zur In-vivo-Wirkung des Withania somnifera (indischer Ginseng)-Extraktes und Shilajit auf die cholinerge, glutamaterge und GABAerge Neurotransmission : eine autoradiographische Studie /." 1998. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=008163213&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Dummer, Karen Joanne. "A controlled in vitro study of the effectiveness of Withania somnifera herbal tincture and homoeopathic dilution (1X and 6X) against selected gram-positive and gram-negative bacteriaBACTERIA." Thesis, 2003. http://hdl.handle.net/10321/2124.

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Mini-dissertation submitted in partial compliance with the requirements of the Master's Degree in Technology: Homoeopathy, Durban Institute of Technology, 2003.<br>The aim of this study was to establish the efficacy of Withania somnifera in tincture, 1X and 6X homoeopathic dilutions (in 62% v/v ethanol) as an antimicrobial agent against the in vitro growth of Bacillus cereus, Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli and Staphylococcus aureus, as compared to 62% v/v ethanol only. The disc diffusion method was employed. W somnifera is indigenous to southern Africa and

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