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1

Patel, JS, MR Patel, Reddy B. A, and BL Raghunandan. "Spirulina: nutritional and therapeutic review." AgriSustain-An International Journal 01, no. 01 (2023): 11–15. https://doi.org/10.5281/zenodo.8385372.

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The current environmental conditions deteriorations, mental and physical stress, changes in the diet have been serious risk factors for the humans, increased the death rate and civilization diseases. These are the obvious reasons why new progressive trends are being extensively developed in modern medicine, pharmacology and biotechnology and more effective harmless medicaments are being sought for to treat and prevent various diseases. One of the trends in biotechnology is associated with Blue green microalgae Spirulina platensis which have been widely employed as food and feed additives in ag
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Ramos, Sergiana dos Passos, Monize Bürck, Stephanie Fabrícia Francisco da Costa, Marcelo Assis, and Anna Rafaela Cavalcante Braga. "Spirulina as a Key Ingredient in the Evolution of Eco-Friendly Cosmetics." BioTech 14, no. 2 (2025): 41. https://doi.org/10.3390/biotech14020041.

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Limnospira spp., commercially known as spirulina, is widely recognized for its remarkable benefits due to its rich composition of bioactive compounds like phycobiliproteins, carotenoids, and phenolic compounds. These natural bioactive compounds not only serve as colorants but also offer potent antioxidant, anti-inflammatory, immunomodulatory, anticancer, antimicrobial, and anti-aging properties. As a result, spirulina and its components are increasingly used in cosmetic formulations to promote skin hydration, reduce wrinkles, and protect against UV radiation damage. Its bioactive components en
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3

Ganga .C.S, Ganga C. S., Mrs Jiji Mohan M. U. Mrs. Jiji Mohan .M.U, Dr Daniel Xavier Prasad Dr. Daniel Xavier Prasad, Dr Prasobh G. R. Dr. Prasobh .G.R, Mr Ajai Franco S. R. Mr. Ajai Franco .S.R, and Mrs Gini Jameena Mrs. Gini Jameena. "A Review on the Potential Benefits and Future Prospects of Spirulina." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 2099–107. https://doi.org/10.35629/4494-100320992107.

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Spirulina is a cyanobacterium that has substantial nutritional and medicinal value due to its high protein, vitamin, mineral, and bioactive compound content. Its lipid-lowering, immunomodulatory, neuroprotective, antiinflammatory, and antioxidant qualities support its use in the treatment of diabetes, cancer, cardiovascular, and neurodegenerative illnesses. Its biomass yield and production of bioactive metabolites are intended to be increased by recent developments in cultivation, genetic engineering, and bioprocess optimization. Spirulina has a wide range of uses in food, medicine, biofuels,
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Michael, Angelina, Margareth Serapio Kyewalyanga, and Charles Venance Lugomela. "Biomass and nutritive value of Spirulina (Arthrospira fusiformis) cultivated in a cost-effective medium." Annals of Microbiology 69, no. 13 (2019): 1387–95. http://dx.doi.org/10.1007/s13213-019-01520-4.

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Abstract Introduction Cultivation of spirulina at commercial-scales relies on analytical grade–based media, which are expensive and so are the product. Purpose This study assessed the biomass, proximate composition, and other useful compounds in Spirulina (Arthrospira fusiformis) produced with a cost-effective culture medium (LCMA), and the results were compared with those from a standard Zarrouk medium–grown spirulina. Methods The LCMA medium was formulated by using a commercial NPK10-20-20 fertilizer as a source of the three major nutrients for spirulina growth, and other three ingredients f
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5

Sankarapandian, Vidya, Kirubakaran Nitharsan, Kavitha Parangusadoss, et al. "Prebiotic Potential and Value-Added Products Derived from Spirulina laxissima SV001—A Step towards Healthy Living." BioTech 11, no. 2 (2022): 13. http://dx.doi.org/10.3390/biotech11020013.

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Lately, microalgae-based value-added products have been gaining market value because they moderate the dependency on fossil fuel and high-value chemical products. To this end, the purpose of this study was to develop prebiotic products from the microalgae Spirulina sp. The microalgae were isolated from the fresh water and characterized at the molecular level. The dry biomass, chlorophyll content, phycocyanin, cytotoxicity and antimicrobial and antioxidant properties of the isolated strains were analyzed. Moreover, value-added products like Spirulina cake, chocolate, tea, vermicelli and Spiruli
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6

Sankarapandian, Vidya, Kirubakaran Nitharsan, Kavitha Parangusadoss, et al. "Prebiotic Potential and Value-Added Products Derived from Spirulina laxissima SV001—A Step towards Healthy Living." BioTech 11, no. 2 (2022): 13. http://dx.doi.org/10.3390/biotech11020013.

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Lately, microalgae-based value-added products have been gaining market value because they moderate the dependency on fossil fuel and high-value chemical products. To this end, the purpose of this study was to develop prebiotic products from the microalgae Spirulina sp. The microalgae were isolated from the fresh water and characterized at the molecular level. The dry biomass, chlorophyll content, phycocyanin, cytotoxicity and antimicrobial and antioxidant properties of the isolated strains were analyzed. Moreover, value-added products like Spirulina cake, chocolate, tea, vermicelli and Spiruli
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7

Nair, Keerthi G. S., Yamuna Ravikumar, Sathesh Kumar Sukumaran, and Ramaiyan Velmurugan. "Fabrication, Optimization and Characterization of Paclitaxel and Spirulina Loaded Nanoparticles for Enhanced Oral Bioavailability." Current Nanoscience 16, no. 5 (2020): 723–33. http://dx.doi.org/10.2174/1573413716666200203115101.

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Background: Paclitaxel and spirulina when administered as nanoparticles, are potentially useful. Methods: Nanoformualtions of Paclitaxel and Spirulina for gastric cancer were formulated and optimized with Central composite rotatable design (CCRD) using Response surface methodology (RSM). Results: The significant findings were the optimal formulation of polymer concentration 48 mg, surfactant concentration 45% and stirring time of 60 min gave rise to the EE of (98.12 ± 1.3)%, DL of (15.61 ± 1.9)%, mean diameter of (198 ± 4.7) nm. The release of paclitaxel and spirulina from the nanoparticle mat
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8

Tzachor, Asaf, Or Rozen, Soliman Khatib, Sophie Jensen та Dorit Avni. "Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-α Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy". Marine Biotechnology 23, № 1 (2021): 149–55. http://dx.doi.org/10.1007/s10126-021-10020-z.

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AbstractAn array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequentlyhypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respiratory distress syndrome (ARDS). Recognizing the therapeutic potential of Spirulina blue-green algae (Arthrospira platensis), in this in vitro stimulation study, LPS-activated macrophages and monocytes were treated with aqueous extracts of Spirulina, cultivated in either natural or controlled light
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9

Islam, Jahid M. M., Md Ismail, Md Rakibul Islam, Md Faruk Hossain, and Hossain Uddin Shekhar. "Boosting the Food Functionality (In Vivo and In Vitro) of Spirulina by Gamma Radiation: An Inspiring Approach." International Journal of Food Engineering 11, no. 4 (2015): 579–85. http://dx.doi.org/10.1515/ijfe-2014-0342.

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Abstract Foods (natural or processed) containing known biologically active compounds, which supplies clinically established and well-documented health benefits, are termed as functional food. Study objectives were to boost food functionality of spirulina, to optimize the required radiation dose, and to test functionality of spirulina both in vitro and in vivo. For this purpose fat binding capacity, sugar binding capacity, hydration property, antioxidative property, total polyphenol content were assessed at different radiation doses. A total of 30 rats were divided into three groups to carry ou
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10

Kulshreshtha, Archana, Anish J., Urmila Jarouliya, Pratiksha Bhadauriya, G. Prasad, and P. Bisen. "Spirulina in Health Care Management." Current Pharmaceutical Biotechnology 9, no. 5 (2008): 400–405. http://dx.doi.org/10.2174/138920108785915111.

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11

Antony, Tibor. "Biotechnology of Spirulina in Design: Sustainable Food Production in Urban Interiors." International Journal of Designed Objects 16, no. 1 (2022): 79–96. http://dx.doi.org/10.18848/2325-1379/cgp/v16i01/79-96.

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12

Lukavsky, J. "Vonshak, A. (Ed.): Spirulina platensis (Arthrospira). Physiology, Cell Biology and Biotechnology." Photosynthetica 38, no. 4 (2000): 552. http://dx.doi.org/10.1023/a:1012498515734.

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13

Ajeesh, M., C. P. N. Bohra, N. Gupta, and C. Rajasekaran. "Spirulina as ‘functional food’." New Biotechnology 25 (September 2009): S285. http://dx.doi.org/10.1016/j.nbt.2009.06.644.

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14

Gupta, N. "Spirulina as “functional food”." New Biotechnology 25 (September 2009): S294. http://dx.doi.org/10.1016/j.nbt.2009.06.670.

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15

Christaki, Efterpi, Maria Karatzia, Eleftherios Bonos, Panagiota Florou Paneri, and Charilaos Karatzias. "Dietary spirulina in dairy cows." Current Opinion in Biotechnology 22 (September 2011): S40. http://dx.doi.org/10.1016/j.copbio.2011.05.097.

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16

Christaki, Efterpi, Eleftherios Bonos, Domniki Paneri, Dimitrios Foskolos, and Panagiota Florou Paneri. "Dietary spirulina against aging brain." Current Opinion in Biotechnology 22 (September 2011): S90—S91. http://dx.doi.org/10.1016/j.copbio.2011.05.277.

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17

Mahajan, G., and M. Kamat. "?-Linolenic acid production from Spirulina platensis." Applied Microbiology and Biotechnology 43, no. 3 (1995): 466–69. http://dx.doi.org/10.1007/s002530050435.

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18

Lodi, A., L. Binaghi, C. Solisio, A. Converti, and M. Del Borghi. "Nitrate and phosphate removal by Spirulina platensis." Journal of Industrial Microbiology and Biotechnology 30, no. 11 (2003): 656–60. http://dx.doi.org/10.1007/s10295-003-0094-5.

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19

Converti, A., S. Scapazzoni, A. Lodi, and J. C. M. Carvalho. "Ammonium and urea removal by Spirulina platensis." Journal of Industrial Microbiology & Biotechnology 33, no. 1 (2005): 8–16. http://dx.doi.org/10.1007/s10295-005-0025-8.

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20

Khan, Z., P. Bhadouria, and P. Bisen. "Nutritional and Therapeutic Potential of Spirulina." Current Pharmaceutical Biotechnology 6, no. 5 (2005): 373–79. http://dx.doi.org/10.2174/138920105774370607.

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21

Abo-Shady, A. M., S. M. Abou-El-Souod, Abd El-Raheem, R. El-Shanshoury, and Y. A. G. Mahmoud. "Protoplasts from the cyanobacterium,Spirulina platensis." World Journal of Microbiology & Biotechnology 8, no. 4 (1992): 385–86. http://dx.doi.org/10.1007/bf01198750.

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22

Al Mahrouqi, Hafidh, Sergey Dobretsov, and Roberto Tefilo Abdala-Daz. "The effect of Spirulina (Arthrospira platensis) as a microbial diatory feed supplement for juvenile of Nile Tilapia (Oreochromis niloticus)." Applied Environmental Biotechnology 8, no. 1 (2023): 1–8. http://dx.doi.org/10.26789/aeb.2023.01.001.

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Tilapia is the second most farmed fish in tropical and sub-tropical countries worldwide. This study investigated the effect of replacing fish meal by Spirulina platensis (groups fed with 5%, 10% and 15% Spirulina) on the growth of Nile tilapia O. niloticus juveniles. Intestinal microbiota of tilapia has been studied by MiSeq Illumina sequencing. No significant differences (P > 0.05) were observed for the protein, carbohydrate and lipids of fish fed with control food and different concentrations of spirulina. However, the Margalef species richness of the intestinal bacteria of tilapia fed wi
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23

Thip-uten, Tarika, Patcharaporn Tippayawat, Bundit Yuangsoi, and Sutee Wongmaneeprateep. "Dietary Spirulina (Arthrospira platensis) Supplementation on Growth Performance, Haematology, Immune Response and Disease Resistance of Rugose Frog (Hoplobatrachus rugulosus)." Journal of Pure and Applied Microbiology 15, no. 3 (2021): 1139–49. http://dx.doi.org/10.22207/jpam.15.3.03.

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The present study aimed to investigate the effects of dietary Spirulina (Arthrospira platensis) supplementation on the growth, survival, haematology, immune parameters and disease resistance of Rugose frog (Hoplobatrachus rugulosus) against Aeromonas hydrophila infection. Frogs were fed a formulated diet containing Spirulina as 0% (control), 1.5%, 3.0%, 4.5%, and 6.0% for a period of eight weeks. The results indicated that growth parameters; final body weight, weight gain, average daily gain, specific growth rate, feed conversion ratio, and survival rate of frog fed with A. platensis at the le
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24

Papini, Alessio. "Who discovered Spirulina? An answer to Soni et al. “Spirulina- from growth to nutritional product: A review”." Trends in Food Science & Technology 134 (April 2023): 230–31. http://dx.doi.org/10.1016/j.tifs.2023.03.008.

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25

Mahajan, G., та M. Kamat. "γ-Linolenic acid production from Spirulina platensis". Applied Microbiology and Biotechnology 43, № 3 (1995): 466–69. http://dx.doi.org/10.1007/bf00218450.

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Yada, Etsuko, Hiroyuki Nagata, Yukinori Noguchi, et al. "An Arginine Specific Protease from Spirulina platensis." Marine Biotechnology 7, no. 5 (2005): 474–80. http://dx.doi.org/10.1007/s10126-004-4115-9.

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Moraes, Iracema de Oliveira, Regina de Oliveira Moraes Arruda, Natália Rocha Maresca, Aline de Oliveira Antunes, and Rodrigo de Oliveira Moraes. "Spirulina platensis: process optimization to obtain biomass." Ciência e Tecnologia de Alimentos 33 (February 2013): 179–83. http://dx.doi.org/10.1590/s0101-20612013000500026.

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Vannela, Raveender, and Sanjay Kumar Verma. "Co2+, Cu2+, and Zn2+ Accumulation by Cyanobacterium Spirulina platensis." Biotechnology Progress 22, no. 5 (2008): 1282–93. http://dx.doi.org/10.1021/bp060075s.

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Xue, Shengzhang, Zhenfeng Su, and Wei Cong. "Growth of Spirulina platensis enhanced under intermittent illumination." Journal of Biotechnology 151, no. 3 (2011): 271–77. http://dx.doi.org/10.1016/j.jbiotec.2010.12.012.

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Pan, Yuelei, Ning Zou, Yan Liang, Jinpei Geng, Donghong Sun, and Linde Liu. "Large-scale cultivation of Spirulina platensis in Shandong." Journal of Biotechnology 136 (October 2008): S565. http://dx.doi.org/10.1016/j.jbiotec.2008.07.1331.

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LUCAS, Bárbara Franco, Ana Priscila Centeno da ROSA, Lisiane Fernandes de CARVALHO, Michele Greque de MORAIS, Thaisa Duarte SANTOS, and Jorge Alberto Vieira COSTA. "Snack bars enriched with Spirulina for schoolchildren nutrition." Food Science and Technology 40, suppl 1 (2020): 146–52. http://dx.doi.org/10.1590/fst.06719.

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32

Reinehr, Christian Oliveira, and Jorge Alberto Vieira Costa. "Repeated batch cultivation of the microalga Spirulina platensis." World Journal of Microbiology and Biotechnology 22, no. 9 (2006): 937–43. http://dx.doi.org/10.1007/s11274-006-9138-0.

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Singh, Nirbhay Kumar, and Dolly Wattal Dhar. "Phylogenetic relatedness among Spirulina and related cyanobacterial genera." World Journal of Microbiology and Biotechnology 27, no. 4 (2010): 941–51. http://dx.doi.org/10.1007/s11274-010-0537-x.

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Abd El-Baky, Hanaa H., and Gamal S. El-Baroty. "Spirulina maxima L-asparaginase: Immobilization, Antiviral and Antiproliferation Activities." Recent Patents on Biotechnology 14, no. 2 (2020): 154–63. http://dx.doi.org/10.2174/1872208313666191114151344.

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Background: L-asparaginase (L-AsnA) enzyme has gained significant attention in the food, biocatalysts and pharmaceutics industry. It (L-AsnA) has been widely used in food processing industries as a promising acrylamide mitigating agent and as a therapeutic agent in the treatment of certain human cancers. Objective: Based on US Patent (4,433,054; 1984), L-asparaginase (L-AsnA) enzyme is immobilized by admixing the active enzyme on the polysaccharide to be in a gel form. The storage stability of immobilized L-AsnA enzyme and its anti-proliferation and antiviral activity were determined. Methods:
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35

Torre, Paolo, Carlos E. N. Sassano, Sunao Sato, Attilio Converti, Luiz A. Gioielli, and João C. M. Carvalho. "Fed-batch addition of urea for Spirulina platensis cultivation." Enzyme and Microbial Technology 33, no. 5 (2003): 698–707. http://dx.doi.org/10.1016/s0141-0229(03)00217-5.

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Abreu, Ana P., Rodrigo Martins, and João Nunes. "Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp." Bioengineering 10, no. 8 (2023): 955. http://dx.doi.org/10.3390/bioengineering10080955.

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Chlorella sp. and Spirulina (Arthrospira) sp. account for over 90% of the global microalgal biomass production and represent one of the most promising aquiculture bioeconomy systems. These microorganisms have been widely recognized for their nutritional and therapeutic properties; therefore, a significant growth of their market is expected, especially in the nutraceutical, food, and beverage segments. However, recent advancements in biotechnology and environmental science have led to the emergence of new applications for these microorganisms. This paper aims to explore these innovative applica
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Sun, Li, Shumei Wang, and Zhiyong Qiao. "Chemical stabilization of the phycocyanin from cyanobacterium Spirulina platensis." Journal of Biotechnology 121, no. 4 (2006): 563–69. http://dx.doi.org/10.1016/j.jbiotec.2005.08.017.

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Zheng, Jiang, and Yahui Gao. "Growth and calcium bioaccumulation of Spirulina in photoheterotrophic cultures." Journal of Biotechnology 136 (October 2008): S560. http://dx.doi.org/10.1016/j.jbiotec.2008.07.1318.

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Kwei, C. K., D. M. Lewis, K. D. King, W. Donohue, and B. A. Neilan. "Therapeutic potential of Spirulina for the treatment of HIV." Journal of Biotechnology 136 (October 2008): S580. http://dx.doi.org/10.1016/j.jbiotec.2008.07.1368.

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Terra, Ana Luiza Machado, Nidria Dias Cruz, Adriano Seizi Arruda Henrard, Jorge Alberto Vieira Costa, and Michele Greque de Morais. "Simultaneous Biosynthesis of Silver Nanoparticles with Spirulina sp. LEB 18 Cultivation." Industrial Biotechnology 15, no. 4 (2019): 263–67. http://dx.doi.org/10.1089/ind.2018.0022.

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Arbianti, Rita, Sri Amini, and Tania Surya Utami. "Produksi pelengkap nutrisi dari mikroalga laut Spirulina platensis dan Botyrococcus braunii." Jurnal Teknik Kimia Indonesia 12, no. 2 (2018): 243. http://dx.doi.org/10.5614/jtki.2013.12.2.3.

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Production of nutritional supplements from Spirulina platensis and Botyrococcus Braunii marine microalgae.The low level of health of pregnant women is one of the results from the deficiency of omega-3 and omega-6 fatty acids in Indonesia. Giving supplement containing DHA, EPA, and AA, can solve the problem. Usually, these nutritional supplements are produced from marine fish oil. However, this source has several deficiencies that influence the quality of the fatty acid produced. Therefore, alternative sources of oil need to be found that can replace fish oil to produce DHA, EPA, and AA. One of
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42

Christaki, Efterpi, Eleftherios Bonos, Dimitrios Foskolos, Domniki Paneri, Elina Sarikaki, and Panagiota Florou Paneri. "The effect of dietary spirulina in infant brain." Current Opinion in Biotechnology 22 (September 2011): S91. http://dx.doi.org/10.1016/j.copbio.2011.05.279.

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Moraes, Luiza, Gabriel Martins da Rosa, Bruna Barcelos Cardias, Lucielen Oliveira dos Santos, and Jorge Alberto Vieira Costa. "Microalgal biotechnology for greenhouse gas control: Carbon dioxide fixation by Spirulina sp. at different diffusers." Ecological Engineering 91 (June 2016): 426–31. http://dx.doi.org/10.1016/j.ecoleng.2016.02.035.

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44

Dheetcha, Arun, and Sandhya Mishra. "Biosequestering Potential of Spirulina platensis for Uranium." Current Microbiology 57, no. 5 (2008): 508–14. http://dx.doi.org/10.1007/s00284-008-9277-7.

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Barrocal, V. M., M. T. García-Cubero, G. García-Benito, M. Pinto, and M. Coca. "Utilization of beet vinasse for cultivation of microalga spirulina platensis." Journal of Biotechnology 150 (November 2010): 249. http://dx.doi.org/10.1016/j.jbiotec.2010.09.121.

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Danesi, Eliane Dalva Godoy, Ailton Cesar Lemes, Katiuchia Pereira Takeuchi, and João Carlos Monteiro Carvalho. "Development of Fresh Pasta with Addition of Spirulina platensis Biomass." Journal of Biotechnology 150 (November 2010): 310. http://dx.doi.org/10.1016/j.jbiotec.2010.09.285.

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47

Carlozzi, P., and G. Torzillo. "Productivity of Spirulina in a strongly curved outdoor tubular photobioreactor." Applied Microbiology and Biotechnology 45, no. 1-2 (1996): 18–23. http://dx.doi.org/10.1007/s002530050642.

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48

Rakow, Allen, and Daniel Fernald. "Concentration of Spirulina Suspensions by Radial Migration with Flow Through Vertical Tees." Biotechnology Progress 7, no. 4 (1991): 343–47. http://dx.doi.org/10.1021/bp00010a600.

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Ginting, M. Iqbal Maulana, Eko Agus Suyono, Mochammad Donny Koerniawan, Lucia Tri Suwanti, Ulfah Juniarti Siregar, and Arief Budiman. "The Effect of Liquid Organic Fertilizer “Bio Ferti” Application on the Growth Rate of <i>Spirulina platensis</i> by Using Haldane Model." Journal of Tropical Biodiversity and Biotechnology 7, no. 2 (2022): 68944. http://dx.doi.org/10.22146/jtbb.68944.

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This experimental research was performed to observe the influence of an agricultural liquid organic fertilizer called Bio Ferti on the growth and biomass of Spirulina platensis, aiming at replacing inorganic fertilizer with the liquid organic one. The cultivation of the microalgae was conducted over seven days at Nogotirto Algae Park. The liquid organic fertilizer, namely Bio Ferti, was obtained from the Faculty of Biology, Universitas Gadjah Mada, and prepared to have doses of 2, 4, 6, 8, and 10 mL. For comparison, an inorganic fertilizer with the same doses was also prepared. The variables t
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Cogne, Guillaume, J. B. Gros, and C. G. Dussap. "Identification of a metabolic network structure representative ofarthrospira (spirulina) platensis metabolism." Biotechnology and Bioengineering 84, no. 6 (2003): 667–76. http://dx.doi.org/10.1002/bit.10808.

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