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Artykuły w czasopismach na temat "Stearoyl CoA desaturase"

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Oatman, Nicole, Julie Reisz, Angelo D’Alessandro, and Biplab Dasgupta. "TAMI-55. THE EVOLUTIONARY ENIGMA OF FATTY ACID DESATURATION IN GLIOBLASTOMA." Neuro-Oncology 22, Supplement_2 (November 2020): ii225. http://dx.doi.org/10.1093/neuonc/noaa215.942.

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Abstract Fatty acid desaturation is an enzymatic reaction in which a double bond is introduced into an acyl chain. Of the four functionally distinct desaturase subfamilies, the First Desaturase Family of enzymes introduce the first double bond into a saturated fatty acid, resulting in the synthesis of monounsaturated fatty acids (MUFA). MUFA are essential components of membrane and storage lipids and exert a profound influence on the fluidity of biological membranes. A disequilibrium in saturated to unsaturated fatty acid ratio alters cell growth, differentiation and response to external stimu
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Oatman, Nicole, and Biplab Dasgupta. "DDRE-15. THE EVOLUTIONARY ENIGMA OF FATTY ACID DESATURATION IN GLIOBLASTOMA." Neuro-Oncology Advances 3, Supplement_1 (March 1, 2021): i9. http://dx.doi.org/10.1093/noajnl/vdab024.037.

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Abstract Fatty acid desaturation is an enzymatic reaction in which a double bond is introduced into an acyl chain. Of the four functionally distinct desaturase subfamilies, the First Desaturase Family of enzymes introduce the first double bond into a saturated fatty acid, resulting in the synthesis of monounsaturated fatty acids (MUFA). MUFA are essential components of membrane and storage lipids and exert a profound influence on the fluidity of biological membranes. A disequilibrium in saturated to unsaturated fatty acid ratio alters cell growth, differentiation and response to external stimu
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Kawashima, Y., N. Uy-Yu, and H. Kozuka. "Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol." Biochemical Journal 263, no. 3 (November 1, 1989): 897–904. http://dx.doi.org/10.1042/bj2630897.

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The effects of the peroxisome proliferators clofibric acid (p-chlorophenoxyisobutyric acid), tiadenol [2,2′-(decamethylenedithio)diethanol] and perfluoro-octanoic acid (PFOA) on hepatic stearoyl-CoA desaturation in male and female rats were compared. Treatment of male rats with the three peroxisome proliferators increased markedly the activity of stearoyl-CoA desaturase. Administration of clofibric acid or tiadenol to female rats increased greatly the hepatic activity of stearoyl-CoA desaturase, the extent of the increases being slightly less pronounced than those of male rats. In contrast wit
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Kikuchi, Kohtaro, and Hidekazu Tsukamoto. "Stearoyl-CoA desaturase and tumorigenesis." Chemico-Biological Interactions 316 (January 2020): 108917. http://dx.doi.org/10.1016/j.cbi.2019.108917.

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Lu, He, Xin Qin, Jing Zhang, Shuang Zhang, Yu Zhu, and Wei Hua Wu. "Molecular target analysis of stearoyl-CoA desaturase genes of protozoan parasites." Acta Parasitologica 63, no. 1 (March 26, 2018): 48–54. http://dx.doi.org/10.1515/ap-2018-0006.

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AbstractProtozoan parasites can synthesize polyunsaturated fatty acids. They possess stearoyl-CoA desaturase to convert stearate into oleate and linoleate. Stearoyl-CoA desaturase are the key enzymes required for the synthesis of unsaturated fatty acids. It seems attractive to evaluate the possibility of using unsaturated fatty acid biosynthesis pathways as drug targets. In this study, the authors investigate codon usage bias, base composition variations and protein sequence in ten available complete stearoyl-CoA desaturase gene sequences fromToxoplasma gondii,Neospora caninumetc. The results
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Hao, Pan, Xia Cui, Jing Liu, Muzi Li, Yong Fu, and Qun Liu. "Identification and characterization of stearoyl-CoA desaturase in Toxoplasma gondii." Acta Biochimica et Biophysica Sinica 51, no. 6 (May 29, 2019): 615–26. http://dx.doi.org/10.1093/abbs/gmz040.

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Abstract Few information of the function of stearoyl-coenzyme A (CoA) desaturase (SCD) in apicomplaxan parasite has been obtained. In this study, we retrieved a putative fatty acyl-CoA desaturase (TGGT1_238950) by a protein alignment with Plasmodium falciparum SCD in ToxoDB. A typical Δ9-desaturase domain was revealed in this protein. The putative desaturase was tagged with HA endogenously in Toxoplasma gondii, and the endoplasmic reticulum localization of the putative desaturase was revealed, which was consistent with the fatty acid desaturases in other organisms. Therefore, the TGGT1_238950
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Ntambi, James M., Makoto Miyazaki, and Agnieszka Dobrzyn. "Regulation of stearoyl-CoA desaturase expression." Lipids 39, no. 11 (November 2004): 1061–65. http://dx.doi.org/10.1007/s11745-004-1331-2.

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Ntambi, James M., Youngjin Choi, Yeonhwa Park, Jeffrey M. Peters, and Michael W. Pariza. "Effects of Conjugated Linoleic Acid (CLA) on Immune Responses, Body Composition and Stearoyl-CoA Desaturase." Canadian Journal of Applied Physiology 27, no. 6 (December 1, 2002): 617–27. http://dx.doi.org/10.1139/h02-036.

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Conjugated linoleic acid (CLA) has shown a wide range of biologically beneficial effects; reduction of incidence and severity of animal carcinogenesis, reduction of the adverse effects of immune stimulation, reduction of severity of atherosclerosis, growth promotion in young rats, and modulation of stearoyl-CoA desaturase (SCD). One of the most interesting aspects of CLA is its ability to reduce body fat while enhancing lean body mass which is associated with the trans-10,cis-12 isomer of CLA. The effects of CLA are unique characteristics that have not been observed with other polyunsaturated
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Sæther, Thomas, Thien N. Tran, Helge Rootwelt, Bjørn O. Christophersen та Trine B. Haugen. "Expression and Regulation of Δ5-Desaturase, Δ6-Desaturase, Stearoyl-Coenzyme A (CoA) Desaturase 1, and Stearoyl-CoA Desaturase 2 in Rat Testis". Biology of Reproduction 69, № 1 (1 липня 2003): 117–24. http://dx.doi.org/10.1095/biolreprod.102.014035.

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Murphy, D. J., I. E. Woodrow, and K. D. Mukherjee. "Substrate specificities of the enzymes of the oleate desaturase system from photosynthetic tissue." Biochemical Journal 225, no. 1 (January 1, 1985): 267–70. http://dx.doi.org/10.1042/bj2250267.

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In the microsomal fraction from young pea (Pisum sativum L.) leaves, the oleoyl moieties from oleoyl-CoA are principally transferred to the sn-2 position of phosphatidylcholine by oleoyl-CoA:1-acyl-lysophosphatidylcholine acyltransferase. The major product of this acyl transfer is 1-palmitoyl(stearoyl)-2-oleoyl phosphatidylcholine. The 1-palmitoyl(stearoyl)-2-oleoyl phosphatidylcholine is subsequently converted into 1-palmitoyl(stearoyl)-2-linoleoyl phosphatidylcholine by the oleate desaturase complex without equilibrating with the bulk membrane phosphatidylcholine pool. Hence, both the acyl t
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Rozprawy doktorskie na temat "Stearoyl CoA desaturase"

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Al-Jeryan, Lulwa A. "Characterization of a human stearoyl CoA desaturase gene." Thesis, Glasgow Caledonian University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251231.

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Dempsey, Kate E. "Characterisation of a human stearoyl CoA desaturase gene (SCD2)." Thesis, Glasgow Caledonian University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369995.

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MacDonald, Marcia Leigh. "Stearoyl-CoA desaturase : role in metabolic syndrome, atherosclerosis and inflammation." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24653.

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Combination of the risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the "metabolic syndrome," increases the risk of developing diabetes and cardiovascular disease. Stearoyl-coenzyme A desaturase (SCD) activity has been implicated in the metabolic syndrome; however, earlier studies on the beneficial metabolic effects of SCD1 deficiency have been confined to normolipidemic mice, and the role of SCD in the context of atherosclerosis has not been examined. The primary purpose of this thesis was to investigate the effect of decreased SCD activity on susc
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lefrevre, pascal. "Regulation genetique de la stearoyl coa desaturase hepatique de poulet." Rennes, Agrocampus Ouest, 1998. http://www.theses.fr/1998NSARIA07.

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L'importance de la stearoyl coa desaturase hepatique (scd1) a ete mise en evidence dans les mecanismes conduisant a la formation du tissu adipeux abdominal du poulet et plusieurs resultats suggerent l'implication du gene lui-meme dans la variabilite du caractere. Dans le but de verifier si l'hypothese d'une regulation essentiellement transcriptionnelle du gene scd1 hepatique etait verifiee ou non chez le poulet, l'etude de la regulation de l'expression de scd1 par des effecteurs hormonaux a ete entreprise. Ensuite, nous avons cherche a identifier des zones genomiques qui pourraient rendre comp
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Williams, Catherine Ann. "The role of stearoyl-CoA desaturase in lipid and lipoprotein metabolism." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537664.

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Pinnameneni, Srijan Kumar, and s3083722@student rmit edu au. "Role of stearoyl-CoA desaturase1 in fatty acid-induced insulin resistance." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070119.162450.

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Recent investigations suggest that reducing stearoyl CoA desaturase (SCD) 1 expression confers protection against obesity and insulin resistance, whereas others show that increasing SCD1 expression protects cells from lipotoxicity. The overall aim of this thesis was to establish the role of SCD1 expression in fatty acid metabolism and insulin stimulated glucose disposal in skeletal muscle. In vitro and in vivo studies were conducted to investigate the relationship between fatty acid subtype, SCD1 expression and fuel metabolism. The role of fatty acid subtype on fatty acid metabol
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Ferdous, Zannatul. "Functional and phenotypic characterization of the stearoyl CoA desaturase gene of Anopheles coluzzii." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/50707.

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Malaria is an infectious disease caused by Plasmodium parasites that are transmitted by the bite of female Anopheles mosquitoes. Successful acquisition and transmission of malaria parasites requires a female mosquito obtaining a blood meal from human hosts. The blood meal, which is rich in protein, is required for egg development. Most of the ingested protein is converted to lipid and stored in the fat body where vitellogenesis takes place. In this process, saturated fatty acids are converted to unsaturated fatty acids by the stearoyl-CoA desaturase (SCD1). Unsaturated fatty acids are also ess
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Oatman, Nicole. "Mechanisms regulating cancer cell sensitivity and acquired resistance to Stearoyl-CoA Desaturase inhibition." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573572568302598.

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Dance, Lyndsey Jane Elizabeth. "The genetic and molecular mechanism of CLA formation in cattle : the role of stearoyl-CoA desaturase." Thesis, University of Bristol, 2009. http://hdl.handle.net/1983/21aa24ed-b002-4155-a972-3daaabad56ac.

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Feng, Shulan. "Using milk somatic cells to study stearoyl-CoA desaturase enzyme activity in dairy cows." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479368.

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Książki na temat "Stearoyl CoA desaturase"

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Ntambi, Ph.D., James M., ed. Stearoyl-CoA Desaturase Genes in Lipid Metabolism. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7.

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Ph.D. James M. Ntambi. Stearoyl-CoA Desaturase Genes in Lipid Metabolism. Springer, 2013.

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James M. Ntambi Ph.D. Stearoyl-CoA Desaturase Genes in Lipid Metabolism. Springer, 2013.

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Części książek na temat "Stearoyl CoA desaturase"

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Schomburg, Dietmar, and Dörte Stephan. "Stearoyl-CoA desaturase." In Enzyme Handbook, 759–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57942-4_157.

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Popeijus, Herman E. "SCD (Stearoyl-CoA Desaturase)." In Encyclopedia of Signaling Molecules, 4847–53. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101551.

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Popeijus, Herman E. "SCD (Stearoyl-CoA Desaturase)." In Encyclopedia of Signaling Molecules, 1–7. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101551-1.

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Parimoo, Satish, and Pappas Apostolos. "Skin Stearoyl-CoA Desaturase Genes." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 13–25. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_2.

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Bond, Laura M., and James M. Ntambi. "Stearoyl-CoA Desaturase Isoforms 3 and 4: Avenues for Tissue-Specific ∆9 Desaturase Activity." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 131–40. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_11.

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Smith, Stephen B. "Functional Development of Stearoyl-CoA Desaturase Gene Expression in Livestock Species." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 141–59. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_12.

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Bernlohr, David A., and M. Daniel Lane. "Early Studies on Role of Stearoyl-CoA Desaturase During Preadipocyte Differentiation." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 1–11. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_1.

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Cantley, Jennifer L., Lucas M. O’Neill, James M. Ntambi, and Michael P. Czech. "The Cellular Function of Stearoyl-CoA Desaturase-2 in Development and Differentiation." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 119–30. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_10.

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Bernard, L., C. Leroux, and Y. Chilliard. "Expression and Nutritional Regulation of Stearoyl-CoA Desaturase Genes in the Ruminant Mammary Gland: Relationship with Milk Fatty Acid Composition." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 161–93. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_13.

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Watts, Jennifer L. "Physiological Functions and Regulation of C. elegans Stearoyl-CoA Desaturases." In Stearoyl-CoA Desaturase Genes in Lipid Metabolism, 195–207. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7969-7_14.

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Streszczenia konferencji na temat "Stearoyl CoA desaturase"

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Copland, John Alton, Laura A. Marlow, Ilah Bok, James L. Miller, Matsuda Akiko, Yan W. Asmann, Vivekananda Sarangi, et al. "Abstract 192: Targeting stearoyl CoA desaturase 1 (SCD1) in hepatobilliary carcinoma." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-192.

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Luyimbazi, D., A. Akcakanat, L. Zhang, Y. Zheng, and F. Meric-Bernstam. "mTOR modulates cellular fat metabolism by regulating stearoyl-CoA desaturase 1 transcription." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-6030.

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CORRÊA DA SILVA, FELIPE, Licio Augusto Velloso, ROBERTA HADDAD TÓVOLLI, JOSEANE MORARI, LUCAS F R NASCIMENTO, and DANIELA S RAZOLLI. "Characterization of Stearoyl-CoA Desaturase 2 (SCD2) in the Brain of Rodents." In XXIV Congresso de Iniciação Científica da UNICAMP - 2016. Campinas - SP, Brazil: Galoa, 2016. http://dx.doi.org/10.19146/pibic-2016-51647.

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Roemeling, Christina Anna Elizabeth Von, Thomas Caulfield, Yaqing Qie, Derek C. Radisky, Xiujie Liu, Yuanxin Chen, Joshua Knight, John Copland, and Betty Kim. "Abstract LB-189: Blockade of stearoyl CoA desaturase 1 promotes immunogenic clearance of tumors." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-189.

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Gleba, Justyna J., Laura A. Marlow, Erin E. Miller, James L. Miller, Aylin Alasonyalilar-Demirer, Yi Guo, Kabir Mody, et al. "Abstract 1004: Defining stearoyl-CoA desaturase 1 as a molecular therapeutic target against cholangiocarcinoma." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1004.

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Belkaid, Anissa, Rodney J. Ouellette, and Marc E. Surette. "Abstract 1706: Estrogen induces stearoyl-CoA desaturase expression in human MCF-7 breast carcinoma cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1706.

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Ma, Kin Fai, Eunice Yuen Ting Lau, Irene Oi Lin Ng, and Kin Wah Lee. "Abstract 4772: Stearoyl-CoA Desaturase (SCD1) regulates liver tumor initiating cells through modulating ER stress." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4772.

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Ma, Kin Fai, Jessica Lo, Eunice Yuen-Ting Lau, John A. Copland, Irene Oi-Lin Ng, and Terence Kin-Wah Lee. "Abstract 1003: Targeting liver-tumor initiating cells via hampering the lipogenesis pathways through stearoyl - CoA desaturase." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1003.

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Sugaru, Eiji, Yudai Furuta, Yuichi Fukunaga, Hiroki Umehara, Tsuguteru Otsubo, Manabu Watanabe, Futoshi Hasegawa, Shingo Tojo, Miki Hashizume, and Hitoshi Ban. "Abstract 3069: DSP-0692, a novel and selective stearoyl-CoA desaturase (SCD) inhibitor targeting cancer stem cells." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3069.

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Holder, Ashley M., Ana M. Gonzalez-Angulo, Huiqin Chen, Argun Akcakanat, Kim Anh-Do, Fraser Symmans, Lajos Pusztai, Gabriel Hortobagyi, Gordon B. Mills, and Funda Meric-Bernstam. "Abstract 682: Increased stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-682.

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