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Artykuły w czasopismach na temat „Steroid crystals”

Autor: Grafiati

Data publikacji: 27 lipca 2024

Data aktualizacji: 31 lipca 2025

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1

Lee, Chung Hun. "Physicochemical Stability and Compatibility of Mixtures of Ropivacaine with Dexamethasone or Betamethasone for Epidural Steroid Injections: An In Vitro Study." Pain Physician Journal 27, no. 1 (2024): E89—E98. http://dx.doi.org/10.36076/ppj.2024.27.e89.

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BACKGROUND: Epidural steroid injections are widely used to treat spinal and radiating pain. However, crystal formation has recently been reported in mixtures of ropivacaine and nonparticulate steroids, commonly used in epidural steroid injections. OBJECTIVES: Our study assessed the physicochemical stability of mixtures of different nonparticulate steroids and ropivacaine and aimed to propose a safe regimen for epidural steroid injections. STUDY DESIGN: An in vitro protocol was used to examine the physicochemical stability of epidural steroid injection mixtures most commonly used at our institu

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Wolf, Steven M., Zachary M. Marsh, Steven M. Quarin, et al. "Investigating the Electro-Optic Response of Steroid Doped Liquid Crystal Devices." Applied Sciences 13, no. 8 (2023): 5054. http://dx.doi.org/10.3390/app13085054.

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Nature is highly efficient at producing chiral compounds that are enantiomerically pure. The inherent chirality of naturally occurring biomolecules means that many have the potential to be used as chiral dopants for cholesteric liquid crystal (CLC) systems. Though many biomolecules have been identified as chiral dopants, many remain yet to be probed for their ability to function as chiral dopants. Here, 10 naturally occurring biomolecules comprised of steroids and bile acids were tested as chiral dopants for CLCs. Progesterone was identified as having high miscibility with nematic liquid cryst

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3

Bhadu, D., S. Vyas, and U. Kumar. "THU0415 MELTING OF TOPHI WITH LOCAL STEROIDS IN CHRONIC TOPHACEOUS GOUT: AN OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 445. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2918.

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Background:Chronic tophaceous gout is usually difficult to treat with urate lowering therapy (ULT) [1]. Faster resolution of tophi has been seen with use of pegloticase [2], but this drug is costly and not widely available. Local steroid use is recommended in acute gouty arthritis but its role in reduction of tophi has not been studied. This study was aimed to see the effect of local steroids in tophi resolution.Objectives:To study the change in size of gouty tophi with local steroid injection compared to conventional treatment.Methods:Four crystal proven chronic tophaceous gout patients with

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4

Fábián, László, Gyula Argay, Alajos Kálmán, and Mária Báthori. "Crystal structures of ecdysteroids: the role of solvent molecules in hydrogen bonding and isostructurality." Acta Crystallographica Section B Structural Science 58, no. 4 (2002): 710–20. http://dx.doi.org/10.1107/s0108768102005608.

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Three crystal forms of the steroid 20-hydroxyecdysone were identified by single-crystal X-ray diffraction analysis: a solvent-free modification, a methanol solvate hydrate and a trihydrate. The structure of a closely related steroid, polypodine B (the 5,20-dihydroxy derivative of ecdysone), was determined in its monohydrate form. Since the unit-cell volume of unsolvated 20-hydroxyecdysone was found to be considerably smaller than that of ecdysone [Huber & Hoppe (1965). Chem. Ber. 98, 2403–2424], a new structure determination of ecdysone was performed, which confirmed the unexpected differe

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5

Grishkovskaya, Irina, Gisela Sklenar, George V. Avvakumov, et al. "Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood." Acta Crystallographica Section D Biological Crystallography 55, no. 12 (1999): 2053–55. http://dx.doi.org/10.1107/s0907444999012883.

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The amino-teminal laminin G-like domain of human sex hormone-binding globulin (SHBG), which contains the steroid-binding site and the dimerization domain, has been produced in Escherichia coli, purified to homogeneity and crystallized in complex with 5α-dihydrotestosterone (DHT) in two different crystal forms. Native data sets have been collected for tetragonal crystals (space group P4122 or P4322; unit-cell parameters a = 52.2, c = 148.4 Å) diffracting to 3.3 Å and trigonal crystals (R32; a = 104.0, c = 84.4 Å) diffracting to better than 1.6 Å. Since both crystal forms can only accommodate a

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6

Frampton, Christopher S., and David D. MacNicol. "Structure of Equilenin at 100 K: an estrone-related steroid." Acta Crystallographica Section E Crystallographic Communications 73, no. 8 (2017): 1223–26. http://dx.doi.org/10.1107/s2056989017010532.

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The structure of the estrone-related steroid, Equilenin, C18H18O2 (systematic name 3-hydroxy-13-methyl-11,12,13,14,15,16-hexahydrocyclopenta[a]phenanthren-17-one), has been determined at 100 K. The crystals are orthorhombic, P212121, and the absolute structure of the molecule in the crystal has been determined by resonant scattering [Flack parameter = −0.05 (4)]. The C atoms of the A and B rings are almost coplanar, with an r.m.s. deviation from planarity of 0.0104 Å. The C ring has a sofa conformation, while the D ring has an envelope conformation with the methine C atom as the flap. The keto

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7

Rychlewska, Urszula, Beata Warżajtis, Roman Joachimiak, and Zdzisław Paryzek. "Synthesis and structural characteristics of lithocholate triads: steroid-type channels occupied by spacer fragments." Acta Crystallographica Section B Structural Science 64, no. 3 (2008): 383–92. http://dx.doi.org/10.1107/s0108768108006514.

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Reported in this paper are the syntheses and X-ray investigations of C 2 symmetrical molecular A—B—A triads consisting of two steroid units (lithocholic acid or its methyl ester) joined together by linkers derived from bifunctional molecules such as terephthalic acid or N,N′-dicarboxypiperazine. Unlike their monomeric analogues, some of these compounds form inclusion complexes. All steroidal triads form crystals that are highly pseudo-centrosymmetric, in which the constituting molecules are held together either exclusively by van der Waals forces or form lattice inclusion complexes, with guest

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8

Turza, Alexandru, Maria O. Miclăuș, Aurel Pop, and Gheorghe Borodi. "Crystal and molecular structures of boldenone and four boldenone steroid esters." Zeitschrift für Kristallographie - Crystalline Materials 234, no. 10 (2019): 671–83. http://dx.doi.org/10.1515/zkri-2019-0030.

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Abstract Androsta-1,4-dien-17β-ol-3-one, also known as boldenone, is an anabolic-androgenic steroid derived from testosterone. The crystal structures of boldenone base, boldenone acetate, boldenone propionate, boldenone cypionate and a boldenone acetate polymorph obtained by high throughput screening were investigated. Hirshfeld surfaces and fingerprint plots breakdown revealed that the molecular packing in the crystals are driven by dominant H⋯H intermolecular contacts, followed by O⋯H/H⋯O contacts and to a lesser degree C⋯H/H⋯C contacts. The steroid skeleton rings, for all the reported compo

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9

Tsoi, Kevin, and Rod Hughes. "An unusual case of steroid responsive idiopathic ectopic calcification." Oxford Medical Case Reports 2019, no. 11 (2019): 466–68. http://dx.doi.org/10.1093/omcr/omz108.

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Abstract This case explores an unusual calcified lesion of the hand and its dramatic response to steroids. A 30-year-old lady presented to rheumatology with a 1-year history of swelling on the radial side of her right middle metacarpophalangeal joint. Over a 2-week period, she had developed swelling throughout her right hand. She was treated with intramuscular methylprednisolone injection and a weaning course of prednisolone. A series of photos and X-rays demonstrates the resolution of swelling and calcification after steroid treatment. This case reports a chronic calcified mass associated wit

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10

Sara, Katti Blessi, Rajan Sundaresan Vediappan, J. Prabaakharan, and Regi Thomas. "Primary Radical Extended Sinus Surgery for Management of Extensive Allergic Fungal Rhinosinusitis." Current Medical Issues 22, no. 3 (2024): 158–63. http://dx.doi.org/10.4103/cmi.cmi_3_24.

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Introduction: Allergic fungal rhinosinusitis (AFRS), a subset of sinusitis secondary to hypersensitivity, is clinically similar to chronic rhinosinusitis with nasal polyp but histologically different with rich eosinophils and Charcot Leyden crystals. Since the primary pathology in AFRS is immune mediated, the recurrence rates are high. In this study, we describe the application of radical extended sinus surgery (RESS) as the surgical technique with the usage of postoperative high-volume steroidal nasal irrigation and short-term oral steroid therapy – a threefold strategy – for the prevention o

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11

Vicatos, Alexios I., Zakiena Hoossen та Mino R. Caira. "Inclusion complexes of the steroid hormones 17β-estradiol and progesterone with β- and γ-cyclodextrin hosts: syntheses, X-ray structures, thermal analyses and API solubility enhancements". Beilstein Journal of Organic Chemistry 18 (22 грудня 2022): 1749–62. http://dx.doi.org/10.3762/bjoc.18.184.

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Overcoming the challenges of poor aqueous solubility of active pharmaceutical ingredients (APIs) is necessary to render them bioavailable. This study addresses the poor solubility of two potent steroid hormones, 17β-estradiol (BES) and progesterone (PRO), via their complexation with two water-soluble native cyclodextrins (CDs) namely β-CD and γ-CD. The hydrated inclusion complexes β-CD·BES, β-CD·PRO, γ-CD·BES and γ-CD·PRO were prepared via kneading and co-precipitation, and 1H NMR spectroscopic analysis of solutions of their pure complex crystals yielded the host–guest stoichiometries 2:1, 2:1

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12

Szyczewski, A. "EPR/ENDOR investigations of γ-irradiated steroid hormone single crystals". Applied Radiation and Isotopes 47, № 11-12 (1996): 1675–81. http://dx.doi.org/10.1016/s0969-8043(96)00234-5.

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González Rojas, Pedro Pablo, Jonathan Restrepo Pérez Restrepo, and Juan Felipe Mantilla Hernández. "Síndrome de la apófisis odontoides coronada, una manifestación inusual de dolor cervical. Presentación de un caso." Revista de la Facultad de Medicina 63, no. 3 (2020): 23–25. http://dx.doi.org/10.22201/fm.24484865e.2020.63.3.04.

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The calcium pyrophosphate dehydrate (CPPD) or hydroxyapatite (HA) crystal deposition disease can appear in any joint and the accumulation fo crystals in the cervical spine may be painful. Crowned dens syndrome is a rare clinical condition that involves crown-like calcification of the ligaments around the odontoid process. A 70-year-old man presented cervical pain, fever and a headache for over a week, therefore, a neurological condition was suspected. A CT scan revealed lentiform calcifications of the transverse ligament of the atlas. Steroid treatment and a non-steroidal anti-inflammatory dim

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14

Asthana, Deepak, Sudhir K. Keshri, Geeta Hundal, Gyaneswar Sharma, and Pritam Mukhopadhyay. "Self-assembly patterns of steroid-based all-organic ferroelectrics: valuable insights from the single-crystals derived from an organogel and solution." CrystEngComm 16, no. 22 (2014): 4861–66. http://dx.doi.org/10.1039/c4ce00013g.

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Gul, Muhammad Tayyab, Norhayati Muhammad, Aslia Natasha Pauzi, et al. "Evaluation of Phyllanthus niruri L. from Malaysia for In-vitro Anti-Urolithiatic Properties by Different Solvent Extraction." Biological Sciences - PJSIR 64, no. 1 (2021): 81–86. http://dx.doi.org/10.52763/pjsir.biol.sci.64.1.2021.81.86.

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 The Phyllanthus niruri is traditionally used for curing of kidney disorders and urinary stones in Malaysia. Hence the current work was aimed to evaluate the effect of different solvents extract (n- hexane, ethyl acetate, methanol and water) of P. niruri for in vitro anti-urolithiatic properties in terms of inhibition activity on CaOx by using the rate of CaOx aggregation assay and dissolution of calcium oxalate (CaOx) crystal by using titrimetry method. Cystone was used as positive control. The effects of cystone on slope of nucleation and aggregation as well as growth of CaOx were eval

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16

Gomes, Ana R., Ana S. Pires, Fernanda M. F. Roleira, and Elisiário J. Tavares-da-Silva. "The Structural Diversity and Biological Activity of Steroid Oximes." Molecules 28, no. 4 (2023): 1690. http://dx.doi.org/10.3390/molecules28041690.

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Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included. Oximes are a chemical group with the general formula R1R2C=N−OH and they exist as colorless crystals and are poorly soluble in water. Oximes can be easily obtained through the condensation of aldehydes or ketones with various amine derivatives, making them a very interesting chemical group in medicinal chemistry for the design of drugs as potential treatments for several diseases. In this review, we will fo

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17

Fatima, Syeda Saima, Rajesh Kumar, M. Iqbal Choudhary, and Sammer Yousuf. "Crystal engineering of exemestane to obtain a co-crystal with enhanced urease inhibition activity." IUCrJ 7, no. 1 (2020): 105–12. http://dx.doi.org/10.1107/s2052252519016142.

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Co-crystallization is a phenomenon widely employed to enhance the physio-chemical and biological properties of active pharmaceutical ingredients (APIs). Exemestane, or 6-methylideneandrosta-1,4-diene-3,17-dione, is an anabolic steroid used as an irreversible steroidal aromatase inhibitor, which is in clinical use to treat breast cancer. The present study deals with the synthesis of co-crystals of exemestane with thiourea by liquid-assisted grinding. The purity and homogeneity of the exemestane–thiourea (1:1) co-crystal were confirmed by single-crystal X-ray diffraction followed by thermal stab

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18

McEwan, Iain J. "From Antibodies to Crystals: Understanding the Structure of the Glucocorticoid Receptor and Related Proteins." Receptors 2, no. 3 (2023): 166–75. http://dx.doi.org/10.3390/receptors2030011.

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The steroid/thyroid hormone or nuclear receptor superfamily is quickly approaching its 40th anniversary. During this period, we have seen tremendous progress being made in our understanding of the mechanisms of action of these physiologically important proteins in the field of health and disease. Critical to this has been the insight provided by ever more detailed structural examination of nuclear receptor proteins and the complexes they are responsible for assembling on DNA. In this article, I will focus on the contributions made by Jan-Åke Gustafsson and colleagues at the Karolinska Institut

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19

Saxena, Rushali, Smita Singh, and Kiran Agarwal. "Steroid Cell Tumor NOS and Xanthogranulomatous Oophoritis: A Rare Association Mimicking Ovarian Malignancy." Annals of Pathology and Laboratory Medicine 10, no. 8 (2023): C126–131. http://dx.doi.org/10.21276/apalm.3272.

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Steroid cell tumor, NOS is an infrequently reported ovarian tumor, rarely presenting without endocrine symptoms. Xanthogranulomatous inflammation of ovaries is an extremely rare finding which often mimics malignancy on imaging. This case report presents a unique co-incidental finding of these two rare entities as incidental findings. A 44 year old female with previous history of total abdominal hysterectomy for leiomyoma presented with abdominal discomfort. Clinical examination revealed bilateral adnexal mass. Imaging suggested a possibility of bilateral ovarian mucinous cystadenocarcinoma. CE

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Dietvorst, Martijn, Ramon Roerdink, Alexander C. A. P. Leenders, Menno A. Kiel, and L. Paul A. "Acute Mono-Arthritis of the Knee: A Case Report of Infection with Parvimonas Micra and Concomitant Pseudogout." Journal of Bone and Joint Infection 1, no. 1 (2016): 65–67. http://dx.doi.org/10.7150/jbji.16124.

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Abstract. Parvimonas micra is a rare pathogen for septic arthritis and is known for its subacute onset. We report a case of acute arthritis of the knee caused by P. micra and pseudogout. Initially, calcium pyrophosphate crystals were found in the knee, which were successfully treated with a steroid injection. Only anaerobic cultures became positive. A 16S rRNA PCR-analysis was necessary to identify P. micra as causative agent, a method which is never described before in similar cases. The infection was treated with clindamycin for 6 weeks. This is the third case report of a septic arthritis ca

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Siegal, Daniel S., Jim S. Wu, Joel S. Newman, Jose L. del Cura, and Mary G. Hochman. "Calcific Tendinitis: A Pictorial Review." Canadian Association of Radiologists Journal 60, no. 5 (2009): 263–72. http://dx.doi.org/10.1016/j.carj.2009.06.008.

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Calcific tendinitis is caused by the pathologic deposition of calcium hydroxyapatite crystals in tendons and is a common cause of joint pain. The disease typically affects the shoulder and hip, with characteristic imaging findings; however, any joint can be involved. Occasionally, calcific tendinitis can mimic aggressive disorders, such as infection and neoplasm, especially on magnetic resonance imaging. Radiologists should be familiar with the imaging findings to distinguish calcific tendinitis from more aggressive processes. Image-guided percutaneous needle aspiration and steroid injection o

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Koo, John, and Gregory D. Deans. "A Rare Case of Burkholderia cepacia Complex Septic Arthritis." Case Reports in Infectious Diseases 2018 (September 16, 2018): 1–3. http://dx.doi.org/10.1155/2018/6232760.

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Bacteria of the Burkholderia cepacia complex have rarely been reported to cause septic arthritis. Cases have been reported in patients who were immunocompromised, at extremes of age or who had history of steroid injection or penetrating trauma. A 67-year-old man with a history of opioid use disorder, osteoarthritis, and gout but no known immunocompromise was admitted to hospital with pain and swelling of his right knee. Cultures of synovial fluid and urine grew Burkholderia cepacia complex. Microscopy of synovial fluid also identified intracellular calcium pyrophosphate crystals. The patient’s

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Xiong, Jing, Dezhong Xu, Hui Zhang, Yan Shi, Xiangxiang Wu, and Sicen Wang. "Improving the Solubility and Bioavailability of Progesterone Cocrystals with Selected Carboxylic Acids." Pharmaceutics 16, no. 6 (2024): 816. http://dx.doi.org/10.3390/pharmaceutics16060816.

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Progesterone (PROG) is a natural steroid hormone with low solubility and high permeability that belongs to biopharmaceutics classification system class II. In this study, novel pharmaceutical cocrystals of PROG were successfully prepared by solvent evaporation or a liquid-assisted grinding process aimed at enhancing its solubility and bioavailability. The cocrystal formers selected based on crystal engineering principles were carboxylic acids, namely, 4-formylbenzeneboronic acid (BBA), isophthalic acid (IPA), and 3-nitrophthalic acid (NPA). The cocrystal structures were characterized using mul

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Okmanov, R. Ya, M. M. Makhmudova, I. D. Bobaev, and B. Tashkhodjaev. "Withanolides from Physalis angulata L." Acta Crystallographica Section E Crystallographic Communications 77, no. 8 (2021): 804–8. http://dx.doi.org/10.1107/s205698902100709x.

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The compounds (17S,20R,22R,24R,25S)-5β,6β:20,24-diepoxy-4β,25-dihydroxy-1-oxowith-2-en-26,22-olide and (20R,22R)-5α,14α,20-Trihydroxy-1-oxo-6α,7α-epoxywitha-2-enolide were isolated from a chloroform extract of the aerial parts of Physalis angulata L. (Solanaceae). Two products were isolated from the chromatographic separation extract. Compound I corresponds to physangulide B chloroform monosolvate, C28H38O7·CHCl3, while compound II is 14α-hydroxyixocarpanolide, C28H40O7. In the two molecular structures, the conformation of the steroid part (rings A, B, C, D) does not differ. In both crystals,

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Mwakyula, Issakwisa Habakkuk, Gloria Reginald Mbwile, Liset M. Torres, and Baraka Michael Chaula. "Atypical presentation of gouty tophi in a resource-limited setting." BMJ Case Reports 18, no. 1 (2025): e263343. https://doi.org/10.1136/bcr-2024-263343.

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A man in his early 50s from Tanzania presented with chronic nodular skin lesions and joint pain, likely due to gout complicated by obesity, after over 15 years of misdiagnosis and ineffective treatment. Despite various therapies for leprosy, tuberculosis and steroid use, his condition worsened, leading to hyperglycaemia and significant financial strain. Missed opportunities to use simple, low-cost diagnostic tests such as ultrasound and examining nodule fluid for urate crystals led to delays in diagnosis. Instead, unnecessary tests were performed, increasing costs without aiding diagnosis. Thi

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LUQUE CUBA, Edith Jacqueline, Freddy GARCIA RAMOS, Adolfo RECHKEMMER PRIETO, et al. "Tumor de células esteroideas de ovario: Reporte de un caso." Revista Medica Herediana 16, no. 1 (2012): 80. http://dx.doi.org/10.20453/rmh.v16i1.867.

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The suggestive clinical characteristics of hyperandrogenism are very common problems in women and have been related with excessive androgen production from ovaries, suprarenal glands or both. The most common identifiable cause of androgen excess is the polycystic ovary syndrome. The virilizing tumors are rare. We report the case of a postmenopausal women with virilizing signs and a left anexial mass. Testosterone 4.3ng/mL (0.2-0.95); DHEAS 56ug/dL (35-430); androstenedione: 10ng/ml (0.4-2.7); Cortisol 16ug/dL. Testosterone post dexamethasone suppression test 3.5ng/mL. Ovarian steroid cell tumo

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Kazymyrko, V. K., L. M. Ivanitska, T. S. Silantieva, and V. V. Kutovyi. "UNIVERSAL THEORY OF ATHEROSCLEROSIS PATHOGENESIS." Likarska sprava, no. 7-8 (December 31, 2019): 3–12. http://dx.doi.org/10.31640/jvd.7-8.2019(1).

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The paper shows that atherosclerosis results from disturbed cholesterol homeostasis in the body, the development of systemic stromal-vascular lipid-protein dystrophy (or lipidosis, or cholesterolosis) complicated by extracellular focal lipid deposits with a predominant cholesterol in the interstitial tissue of the inner arterial and aortic layer. These deposits are foreign to this body tissue. They induce the development of chronic productive granulomatous inflammation in it – granulomatosis around endogenous foreign bodies. Cholesterol deposition is promoted by a positive cholesterol balance

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Ikegami, Kazuhiko, Yoshiaki Kawashima, Hirofumi Takeuchi, et al. "Simultaneous particulate design of primary and agglomerated crystals of steroid by spherical agglomeration in liquid for dry powder inhalation." Powder Technology 130, no. 1-3 (2003): 290–97. http://dx.doi.org/10.1016/s0032-5910(02)00207-3.

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Vorontsova, Svetlana K., Igor V. Zavarzin, Valerii Z. Shirinian, et al. "Synthesis and crystal structures of D-annulated pentacyclic steroids: looking within and beyond AR signalling in prostate cancer." CrystEngComm 24, no. 11 (2022): 2089–99. http://dx.doi.org/10.1039/d1ce01417j.

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Crystal structures of D-annulated steroids were used for docking studies against the human androgen receptor. The combination of the selected steroid with bicalutamide was found to exhibit significant antiproliferative effects in 22Rv1 cells.

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Lequin, R. M., A. van den Boogaard, J. Vermeulen, and M. Danhof. "Progesterone in saliva: pitfalls and consequent implications for accuracy of the determination." Clinical Chemistry 32, no. 5 (1986): 831–34. http://dx.doi.org/10.1093/clinchem/32.5.831.

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Abstract The concentration of steroid hormones in saliva is believed to reflect the concentration of free hormone in blood. Because the assay for progesterone in saliva has not been rigorously validated, we investigated some of the analytical variables involved. Saliva samples were divided into two portions. One was centrifuged and the supernate used for extraction; the other was homogenized by sonication and used as such for extraction. Progesterone concentrations in homogenized whole saliva were double or triple those in supernates. By equilibrium dialysis we established that 85% of progeste

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Maranini, B., S. Mandrioli, M. Galiè, and M. Govoni. "POS0780 PSEUDOGOUT OF THE TEMPOROMANDIBULAR JOINT: A CASE REPORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 682.2–682. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1665.

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BackgroundDeposition of calcium pyrophosphate dihydrate crystals occurs in crystalline arthropathies, such as gout and chondrocalcinosis. Occasionally, crystal deposits may affect the temporomandibular joint (TMJ), especially involving the articular cartilage and fibrocartilage, causing pain and jaw claudication, mimicking giant cell arteritis (GCA). Ultrasound (US) images reveal spotted hyperechoic signals in the articular disk and sometimes a marked destruction of the condyle with erosive changes.ObjectivesTo highlight and discuss the potential role of TMJ US in guiding differential diagnosi

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Herzog, Konrad, Paula Bracco, Akira Onoda, Takashi Hayashi, Kurt Hoffmann, and Anett Schallmey. "Enzyme–substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation." Acta Crystallographica Section D Biological Crystallography 70, no. 11 (2014): 2875–89. http://dx.doi.org/10.1107/s1399004714019129.

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CYP154C5 fromNocardia farcinicais a bacterial cytochrome P450 monooxygenase active on steroid molecules. The enzyme has recently been shown to exhibit exclusive regioselectivity and stereoselectivity in the conversion of various pregnans and androstans, yielding 16α-hydroxylated steroid products. This makes the enzyme an attractive candidate for industrial application in steroid hormone synthesis. Here, crystal structures of CYP154C5 in complex with four different steroid molecules were solved at resolutions of up to 1.9 Å. These are the first reported P450 structures from the CYP154 family in

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Tischler, Mark, Stephen W. Ayer, Raymond J. Andersen, John F. Mitchell, and Jon Clardy. "Anthosterones A and B, ring A contracted steroids from the sponge Anthoracuata graceae." Canadian Journal of Chemistry 66, no. 5 (1988): 1173–78. http://dx.doi.org/10.1139/v88-192.

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Four new steroids, anthosterone A (5), anthosterone B (6), and the Δ4-3,6-diketo steroids 7 and 8, have been isolated from the sponge Anthoarcuata graceae. The structures of anthosterones A (5) and B (6) were deduced from their spectral data and verified via single crystal X-ray diffraction analysis on 5. The proposed structures for steroids 7 and 8 were based on spectral analysis and confirmed by synthesis of a model compound 12. Anthosterones A and B represent the first examples of a new type of ring A contraction in a steroid nucleus.

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Anthony, Addlagatta, Mariusz Jaskólski, and Ashwini Nangia. "Crystal chemistry of some synthetic 2-oxa-steroids: conformation, packing motifs and isostructurality." Acta Crystallographica Section B Structural Science 56, no. 3 (2000): 512–25. http://dx.doi.org/10.1107/s0108768199015542.

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The crystal structures of six synthetic 2-oxa-steroids (A-ring lactone steroids) have been determined by single-crystal X-ray diffraction. The conformation and hydrogen bonding in these oxa-steroids is compared with packing motifs in the natural steroids and the anabolic agent, Anavar®. O—H...O hydrogen bonding with lactone carbonyl O is the preferred arrangement in molecules with a C—OH group. The donor H atoms of A, B and D rings participate in C—H...O interactions with lactone carbonyl O and D-ring hydroxyl/ketone O acceptor atoms. The conformation of the lactone ring in these analogues is

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Kiema, Tiila-Riikka, Chandan J. Thapa, Mikko Laitaoja, et al. "The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry." Biochemical Journal 476, no. 2 (2019): 307–32. http://dx.doi.org/10.1042/bcj20180788.

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Abstract The SCP2 (sterol carrier protein 2)-thiolase (type-1) functions in the vertebrate peroxisomal, bile acid synthesis pathway, converting 24-keto-THC-CoA and CoA into choloyl-CoA and propionyl-CoA. This conversion concerns the β-oxidation chain shortening of the steroid fatty acyl-moiety of 24-keto-THC-CoA. This class of dimeric thiolases has previously been poorly characterized. High-resolution crystal structures of the zebrafish SCP2-thiolase (type-1) now reveal an open catalytic site, shaped by residues of both subunits. The structure of its non-dimerized monomeric form has also been

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Msweli, Siphesihle M., Tiara Padayachee, Thembeka Khumalo, David R. Nelson, David C. Lamb, and Khajamohiddin Syed. "Structure–Function Analysis of the Steroid-Hydroxylating Cytochrome P450 109 (CYP109) Enzyme Family." International Journal of Molecular Sciences 26, no. 13 (2025): 6219. https://doi.org/10.3390/ijms26136219.

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Steroids are found in bacteria and eukaryotes, and genes potentially encoding steroid metabolic enzymes have also been identified in giant viruses. For decades, hydroxylated steroids have been utilized in medicine to treat various human diseases. The hydroxylation of steroids can be achieved using microbial enzymes, especially cytochrome P450 monooxygenases (CYPs/P450s) and is well documented. Understanding the structural determinants that govern the regio- and stereoselectivity of steroid hydroxylation by P450s is essential in order to fully exploit their potential. Herein, we present a compr

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Boyan, Barbara D., Niels C. Asmussen, Zhao Lin, and Zvi Schwartz. "The Role of Matrix-Bound Extracellular Vesicles in the Regulation of Endochondral Bone Formation." Cells 11, no. 10 (2022): 1619. http://dx.doi.org/10.3390/cells11101619.

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Matrix vesicles are key players in the development of the growth plate during endochondral bone formation. They are involved in the turnover of the extracellular matrix and its mineralization, as well as being a vehicle for chondrocyte communication and regulation. These extracellular organelles are released by the cells and are anchored to the matrix via integrin binding to collagen. The exact function and makeup of the vesicles are dependent on the zone of the growth plate in which they are produced. Early studies defined their role as sites of initial calcium phosphate deposition based on t

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Opdebeeck, Britt, Ellen Neven, Stuart Maudsley, et al. "A Proteomic Screen to Unravel the Molecular Pathways Associated with Warfarin-Induced or TNAP-Inhibited Arterial Calcification in Rats." International Journal of Molecular Sciences 24, no. 4 (2023): 3657. http://dx.doi.org/10.3390/ijms24043657.

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Arterial media calcification refers to the pathological deposition of calcium phosphate crystals in the arterial wall. This pathology is a common and life-threatening complication in chronic kidney disease, diabetes and osteoporosis patients. Recently, we reported that the use of a TNAP inhibitor, SBI-425, attenuated arterial media calcification in a warfarin rat model. Employing a high-dimensionality unbiased proteomic approach, we also investigated the molecular signaling events associated with blocking arterial calcification through SBI-425 dosing. The remedial actions of SBI-425 were stron

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Araki, Yoshihiro, Kei Hirose, Maki Hirose, Katsuhiro Hayashi, and Satoru Demura. "The occurrence of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) after arthroplasty mimicking a periprosthetic joint infection: A case report and literature review." Medicine 103, no. 44 (2024): e40344. http://dx.doi.org/10.1097/md.0000000000040344.

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Rationale: As the elderly population grows, the number of joint arthroplasty surgeries is also increasing. Periprosthetic joint infection (PJI) is a postoperative complication that occurs in 1%–2% of the arthroplasties. Once it occurs, PJI is refractory to treatment. Similar symptoms of PJI, including joint synovitis and elevated body temperature, sometimes arise because of crystal arthritis, rheumatoid arthritis, or other inflammatory diseases. Precise diagnosis is essential for determining the optimal treatment strategy. Patient concerns: An 81-year-old female patient with a history of bilat

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Gomes, Ligia R., John N. Low, Alan B. Turner, Alexander W. Nowicki, Thomas C. Baddeley, and James L. Wardell. "Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton – structural comparisons with reported tetrahydrobenz[e]indene derivatives." Zeitschrift für Naturforschung B 74, no. 9 (2019): 649–63. http://dx.doi.org/10.1515/znb-2019-0094.

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AbstractThe crystal structures and Hirshfeld surface analyses of the des-A-B-aromatic steroid derivative, (3a,9b)-1,2,3a,4,5,9b-hexahydro-7-methoxy-3a-methyl-3H-benz[e]-inden-3-one (or 5-methoxy-des-A-estra-5,7,9-triene-17-one) 1, its acetohydrazide derivative, 2, and its hydrazone derivative, 3, are reported. All three compounds crystallize in chiral space groups: compounds 1 and 2 in the orthorhombic space group P212121 each with one molecule in the asymmetric unit, and compound 3 in the monoclinic space group P21 with two similar but independent molecules, Mol A and Mol B, in the asymmetric

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Penning, Trevor M., Phumvadee Wangtrakuldee, and Richard J. Auchus. "Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes." Endocrine Reviews 40, no. 2 (2018): 447–75. http://dx.doi.org/10.1210/er.2018-00089.

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Abstract Aldo-keto reductases (AKRs) are monomeric NAD(P)(H)-dependent oxidoreductases that play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C enzymes acting as 3-ketosteroid, 17-ketosteroid, and 20-ketosteroid reductases are involved in the prereceptor regulation of ligands for the androgen, estrogen, and progesterone receptors and are considered drug targets to treat steroid hormone–dependent malignancies and endocrine disorders. In contrast, AKR1D1 is the only known steroid 5β-reductase and is essential for bile-acid biosynthesis, the generation of ligands fo

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Bouzidi, Lobna, Meriam Triki, Slim Charfi, et al. "Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review." Pediatric and Developmental Pathology 24, no. 2 (2021): 137–41. http://dx.doi.org/10.1177/1093526620980614.

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Ovarian adrenal rest tumors (OART) are tumors that develop in females with congenital adrenal hyperplasia (CAH). In contrast to their counterpart in testicles, they are exceptional and few cases have been reported in the literature. In this report, we present clinicopathological findings of a female patient with CAH due to 21-hydroxylase deficiency who was incidentally diagnosed with OART with a review of the literature. The 14-year-old patient, who was raised as a boy, developed a virilizing syndrome with high testosterone levels that were attributed to non adherence to her replacement cortic

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Nuzzi, Raffaele, Monica Gunetti, Deborah Rustichelli, et al. "Effect ofIn VitroExposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells." Stem Cells International 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/946090.

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Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several treatment options, AMD therapy remains difficult, especially for exudative AMD. Multipotent mesenchymal stem cells (MSCs), with great plasticity and immunomodulant properties, are a promising cell source for cellular therapy and tissue engineering. We evaluated the effects of steroid drugs, often used to treat AMD, in association with MSCs, in view of a possible

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Harrison, William T. A., Lutfun Nahar та Alan B. Turner. "Crystal structure of bis[3-methoxy-17β-estra-1,3,5(10)-trien-17-yl] oxalate". Acta Crystallographica Section E Structure Reports Online 70, № 8 (2014): 62–64. http://dx.doi.org/10.1107/s1600536814009349.

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In the title compound, C40H50O6, a symmetrical steroid oxalate diester, the dihedral angle between the CO2planes of the oxalate linker is 61.5 (5)° and the C—C bond length is 1.513 (6) Å. The steroidB,CandDrings adopt half-chair, chair and envelope conformations, respectively, in both halves of the molecule, which adopts an overall shallow V-shaped conformation. In the crystal, molecules are linked by weak C—H...O interactions, forming a three-dimensional network.

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Daśko, Mateusz, Anna Dołęga, Magdalena Siedzielnik, et al. "Novel 1,2,3-Triazole Derivatives as Mimics of Steroidal System—Synthesis, Crystal Structures Determination, Hirshfeld Surfaces Analysis and Molecular Docking." Molecules 26, no. 13 (2021): 4059. http://dx.doi.org/10.3390/molecules26134059.

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Herein, we present the synthesis and crystal structures determination of five 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives containing halogen atoms, 6a–e, which may be used as an excellent mimic of steroids in the drug development process. Good quality crystals obtained for all of the synthesized compounds allowed the analysis of their molecular structures. Subsequently, the determined crystal structures were used to calculate the Hirshfeld surfaces for each of the synthesized compounds. Furthermore, results of our docking studies indicated that synthesized derivatives are able to bind

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Alam, Mahboob. "Exploration of Binding Affinities of a 3β,6β-Diacetoxy-5α-cholestan-5-ol with Human Serum Albumin: Insights from Synthesis, Characterization, Crystal Structure, Antioxidant and Molecular Docking". Molecules 28, № 16 (2023): 5942. http://dx.doi.org/10.3390/molecules28165942.

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The present study describes the synthesis, characterization, and in vitro molecular interactions of a steroid 3β,6β-diacetoxy-5α-cholestan-5-ol. Through conventional and solid-state methods, a cholestane derivative was successfully synthesized, and a variety of analytical techniques were employed to confirm its identity, including high-resolution mass spectrometry (HRMS), Fourier transforms infrared (FT-IR), nuclear magnetic resonance (NMR), elemental analysis, and X-ray single-crystal diffraction. Optimizing the geometry of the steroid was undertaken using density functional theory (DFT), and

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Latsch, Silvia, Torsten Selzer, Lothar Fink, Michael Horstmann, and Jörg Kreuter. "Use of isothermal heat conduction microcalorimetry, X-ray diffraction, and optical microscopy for characterisation of crystals grown in steroid combination-containing transdermal drug delivery systems." European Journal of Pharmaceutics and Biopharmaceutics 57, no. 2 (2004): 397–410. http://dx.doi.org/10.1016/s0939-6411(03)00120-6.

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Gupta, AK, Rijuneeta LNU, H. Verma, and A. Chakrabarti. "Allergic Fungal Rhinosinusitis Involving Frontal Sinus: A Prospective Study comparing Surgical Modalities." An International Journal Clinical Rhinology 6, no. 1 (2013): 10–15. http://dx.doi.org/10.5005/jp-journals-10013-1141.

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ABSTRACT Allergic fungal rhinosinusitis (AFRS) represents a hypersensitivity response to extramucosal fungi within the sinus cavity without evidence of tissue invasion. AFRS is characterized by fungal element with allergic mucin, Charcot-Leyden crystals, type I hypersensitivity, bony erosion with sinus infection on computed tomographic (CT) scan. Surgery remains the treatment of choice for AFRS followed by prolonged steroid therapy. Surgical approaches for frontal sinus disease can be either endonasal endoscopic or external. This is a nonrandomized prospective study, where the postoperative re

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Fábián, László, Gyula Argay, and Alajos Kálmán. "On the polymorphism of a sapogenin monohydrate induced by different rotations of water molecules." Acta Crystallographica Section B Structural Science 55, no. 5 (1999): 788–92. http://dx.doi.org/10.1107/s0108768199005315.

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The structure of 1β,3β,11α-trihydroxyspirosta-5,25(27)-diene (C27H40O5; a steroidal sapogenin) isolated from Helleborus serbicus Adam 1906 (Ranunculaceae) and crystallized from absolute ethanol as a monohydrate (melting point 519–522 K) had been characterized by two symmetry-independent binary (steroid–water) layers, cross-linked by hydrogen bonds [Kálmán et al. (1985). Acta Cryst. C41, 1645–1647]. Recently, a novel monohydrate was crystallized again from absolute ethanol (source: Helleborus multifidus subspecies serbicus) with a somewhat higher melting point of 525–526 K. X-ray analysis of th

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Albert, Dieter, Martin Feigel, Jordi Benet-Buchholz та Roland Boese. "Crystal Structure of a Peptide-Steroid Macrocycle—Intramolecular Attraction between Steroids and Peptidicβ(I) Turns". Angewandte Chemie International Edition 37, № 19 (1998): 2727–29. http://dx.doi.org/10.1002/(sici)1521-3773(19981016)37:19<2727::aid-anie2727>3.0.co;2-g.

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