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Artykuły w czasopismach na temat „Steroid receptors”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Baker, ME. "Recent insights into the origins of adrenal and sex steroid receptors." Journal of Molecular Endocrinology 28, no. 3 (2002): 149–52. http://dx.doi.org/10.1677/jme.0.0280149.

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The recent cloning by Thornton (2001) of estrogen, progesterone and corticoid receptors from lamprey provides important insights into the early evolution of adrenal and sex steroid receptors and an opportunity to elucidate the ancient steroids that regulated gene transcription. Inclusion of lamprey sequences in a steroid receptor phylogeny indicates that the estrogen receptor is the most ancient of these receptors, followed by the progesterone receptor and the corticoid receptor. Thornton proposed that estradiol was the earliest of the steroids to activate a steroid receptor. An alternative hy

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2

Baker, ME. "Adrenal and sex steroid receptor evolution: environmental implications." Journal of Molecular Endocrinology 26, no. 2 (2001): 119–25. http://dx.doi.org/10.1677/jme.0.0260119.

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The nuclear receptor family responds to a diverse group of ligands, including steroids, retinoids, thyroid hormone, prostaglandins and fatty acids. Previous sequence analyses of adrenal and sex steroid receptors indicate that they form a clade separate from other nuclear receptors. However, the relationships of adrenal and sex steroid receptors to each other and to their ancestors are not fully understood. We have used new information from androgen, estrogen, mineralocorticoid and progesterone receptors in fish to better resolve the phylogeny of adrenal and sex steroid receptors. Sequence dive

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3

Marcinkowska, Ewa, and Antoni Wiedłocha. "Steroid signal transduction activated at the cell membrane: from plants to animals." Acta Biochimica Polonica 49, no. 3 (2002): 735–45. http://dx.doi.org/10.18388/abp.2002_3782.

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Steroid hormones in plants and in animals are very important for physiological and developmental regulation. In animals steroid hormones are recognized by nuclear receptors, which transcriptionally regulate specific target genes following binding of the ligand. In addition, numerous rapid effects generated by steroids appear to be mediated by a mechanism not depending on the activation of nuclear receptors. Although the existence of separate membrane receptors was postulated many years ago and hundreds of reports supporting this hypothesis have been published, no animal membrane steroid recept

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4

Wiseman, Helen, and Rosanna Duffy. "Steroids, steroid receptors and disease." Trends in Molecular Medicine 7, no. 4 (2001): 146–47. http://dx.doi.org/10.1016/s1471-4914(01)01978-5.

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Hammes, Stephen R., and Ellis R. Levin. "Extranuclear Steroid Receptors: Nature and Actions." Endocrine Reviews 28, no. 7 (2007): 726–41. http://dx.doi.org/10.1210/er.2007-0022.

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Rapid effects of steroid hormones result from the actions of specific receptors localized most often to the plasma membrane. Fast-acting membrane-initiated steroid signaling (MISS) 1leads to the modification of existing proteins and cell behaviors. Rapid steroid-triggered signaling through calcium, amine release, and kinase activation also impacts the regulation of gene expression by steroids, sometimes requiring integration with nuclear steroid receptor function. In this and other ways, the integration of all steroid actions in the cell coordinates outcomes such as cell fate, proliferation, d

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6

Adcock, I. M., S. J. Lane, C. R. Brown, M. J. Peters, T. H. Lee, and P. J. Barnes. "Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma." Journal of Immunology 154, no. 7 (1995): 3500–3505. http://dx.doi.org/10.4049/jimmunol.154.7.3500.

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Abstract Although glucocorticosteroids are a very effective treatment for asthma and other chronic inflammatory diseases, a small proportion of patients are resistant to their therapeutic effects. The molecular mechanism for this steroid resistance is unclear. Steroid resistance cannot be explained by pharmacokinetic mechanisms, by a defect in the binding of steroids to glucocorticoid receptors, nor by defective nuclear translocation of this receptor, thereby suggesting that the molecular abnormality lies distal to nuclear translocation. We examined the ability of nuclear translocated glucocor

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7

Godowski, Paul J., and Didier Picard. "Steroid receptors." Biochemical Pharmacology 38, no. 19 (1989): 3135–43. http://dx.doi.org/10.1016/0006-2952(89)90605-9.

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Levin, Ellis R. "Extranuclear estrogen receptor's roles in physiology: lessons from mouse models." American Journal of Physiology-Endocrinology and Metabolism 307, no. 2 (2014): E133—E140. http://dx.doi.org/10.1152/ajpendo.00626.2013.

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Steroid receptors exist and function in multiple compartments of cells in most organs. Although the functions and nature of some of these receptors is being defined, important aspects of receptor localization and signaling to physiology and pathophysiology have been identified. In particular, extranuclear sex steroid receptors have been found in many normal cells and in epithelial tumors, where they enact signal transduction that impacts both nongenomic and genomic functions. Here, I focus on the progress made in understanding the roles of extranuclear estrogen receptors (ER) in physiology and

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9

Mukudai, Shigeyuki, Ken Ichi Matsuda, Takeshi Nishio, et al. "Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus." Endocrinology 156, no. 3 (2015): 1000–1009. http://dx.doi.org/10.1210/en.2014-1605.

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Abstract There is accumulating evidence that fibroblasts are target cells for steroids such as sex hormones and corticoids. The characteristics of fibroblasts vary among tissues and organs. Our aim in this study is to examine differences in responses to steroid hormones among fibroblasts from different cervicothoracic regions. We compared the actions of steroid hormones on cultured fibroblasts from the vocal folds, which are considered to be the primary target of steroid hormones, and the trachea and esophagus in adult male rats. Expression of steroid hormone receptors (androgen receptor, estr

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10

Knutti, Darko, Adesh Kaul, and Anastasia Kralli. "A Tissue-Specific Coactivator of Steroid Receptors, Identified in a Functional Genetic Screen." Molecular and Cellular Biology 20, no. 7 (2000): 2411–22. http://dx.doi.org/10.1128/mcb.20.7.2411-2422.2000.

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ABSTRACT Steroid receptors mediate responses to lipophilic hormones in a tissue- and ligand-specific manner. To identify nonreceptor proteins that confer specificity or regulate steroid signaling, we screened a human cDNA library in a steroid-responsive yeast strain. One of the identified cDNAs, isolated in the screen as ligand effect modulator 6, showed no homology to yeast or Caenorhabditis elegansproteins but high similarity to the recently described mouse coactivator PGC-1 and was accordingly termed hPGC-1. The hPGC-1 DNA encodes a nuclear protein that is expressed in a tissue-specific man

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11

Szczurowska, Ewa, Eszter Szánti-Pintér, Alena Randáková, Jan Jakubík, and Eva Kudova. "Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids." International Journal of Molecular Sciences 23, no. 21 (2022): 13075. http://dx.doi.org/10.3390/ijms232113075.

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Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research

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12

Simoncini, T., and AR Genazzani. "Non-genomic actions of sex steroid hormones." European Journal of Endocrinology 148, no. 3 (2003): 281–92. http://dx.doi.org/10.1530/eje.0.1480281.

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Steroid hormone receptors have been traditionally considered to act via the regulation of transcriptional processes, involving nuclear translocation and binding to specific response elements, and ultimately leading to regulation of gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called 'non-genomic' effects do not depend on gene transcription or protein synthesis and involve steroid-induced modulation of cytoplasmic or cell membrane-bound regulatory proteins. Several relevant biological actio

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13

Mahfouz, Ahmed, Boudewijn P. F. Lelieveldt, Aldo Grefhorst, et al. "Genome-wide coexpression of steroid receptors in the mouse brain: Identifying signaling pathways and functionally coordinated regions." Proceedings of the National Academy of Sciences 113, no. 10 (2016): 2738–43. http://dx.doi.org/10.1073/pnas.1520376113.

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Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different physiological states. An important target organ is the brain, but even though their effects are well studied in specific regions, brain-wide steroid receptor targets and mediators remain largely unknown due to the complexity of the brain. Here, we tested the idea that novel aspects of steroid action can be identified through spatial correlation of steroid receptors with genome-wide mRNA expression across different regions in the mouse brain. First, we observed significant coexpression of six nuclear

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14

Kadiyala, Vineela, and Catharine L. Smith. "Minireview: The Versatile Roles of Lysine Deacetylases in Steroid Receptor Signaling." Molecular Endocrinology 28, no. 5 (2014): 607–21. http://dx.doi.org/10.1210/me.2014-1002.

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AbstractLysine deacetylases have been known to regulate nuclear receptor function for many years. In the unliganded state, nuclear receptors that form heterodimers with retinoid X receptors, such as the retinoic acid and thyroid hormone receptors, associate with deacetylases to repress target genes. In the case of steroid receptors, binding of an antagonist ligand was initially reported to induce association of deacetylases to prevent activation of target genes. Since then, deacetylases have been shown to have diverse functions in steroid receptor signaling, from regulating interactions with m

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15

Plese, J. P. P., V. R. Martins, M. T. P. Lopes, and M. M. Brentani. "Steroid receptors in meningiomas." Arquivos de Neuro-Psiquiatria 43, no. 4 (1985): 365–71. http://dx.doi.org/10.1590/s0004-282x1985000400005.

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Cytosolic estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in 10 meningiomas using a dextran charcoal coated method. We consider as positive specific receptor values >10fMol/mg protein. In this study 20% of the meningiomas contained very low titers of specific ER. PR was detectable in 90% of the tumors, at high levels. The mean PR content of PR+ tumors was 60±38fMol/mg prot. GR and AR were present in moderate levels, in 70% of the tumors. Competition studies demonstrated steroid specificity for these hormone-binding proteins. Female patients h

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16

Chao, Helen M., Randall R. Sakai, Li Yun Ma, and Bruce S. McEwen. "Adrenal Steroid Regulation of Neurotrophic Factor Expression in the Rat Hippocampus." Endocrinology 139, no. 7 (1998): 3112–18. http://dx.doi.org/10.1210/endo.139.7.6114.

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Abstract Adrenal steroids and neurotrophic factors are important modulators of neuronal plasticity, function, and survival in the rat hippocampus. Adrenal steroids act through two receptor subtypes, the glucocorticoid receptor (GR) and the mineralocorticoid receptor, and activation of each receptor subtype has distinct biochemical and physiological consequences. Adrenal steroids may exert their effects on neuronal structure and function through the regulation of expression of neurotrophic and growth-associated factors. We have examined adrenal steroid regulation of the neurotrophins brain-deri

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17

Kahn, SM, DJ Hryb, AM Nakhla, NA Romas, and W. Rosner. "Sex hormone-binding globulin is synthesized in target cells." Journal of Endocrinology 175, no. 1 (2002): 113–20. http://dx.doi.org/10.1677/joe.0.1750113.

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Sex hormone-binding globulin (SHBG) is a multifunctional protein that acts in humans to regulate the response to steroids at several junctures. It was originally described as a hepatically secreted protein that is the major binding protein for sex steroids in plasma, thereby regulating the availability of free steroids to hormone-responsive tissues. SHBG also functions as part of a novel steroid-signaling system that is independent of the classical intracellular steroid receptors. Unlike the intracellular steroid receptors that are ligand-activated transcription factors, SHBG mediates androgen

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18

Evaul, Kristen, Michelle Jamnongjit, Bala Bhagavath та Stephen R. Hammes. "Testosterone and Progesterone Rapidly Attenuate Plasma Membrane Gβγ-Mediated Signaling in Xenopus laevis Oocytes by Signaling through Classical Steroid Receptors". Molecular Endocrinology 21, № 1 (2007): 186–96. http://dx.doi.org/10.1210/me.2006-0301.

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Abstract Many transcription-independent (nongenomic) steroid effects are regulated by G proteins. A well-established, biologically relevant example of steroid/G protein interplay is steroid-triggered oocyte maturation, or meiotic resumption, in Xenopus laevis. Oocyte maturation is proposed to occur through a release of inhibition mechanism whereby constitutive signaling by Gβγ and other G proteins maintains oocytes in meiotic arrest. Steroids (androgens in vivo, and androgens and progesterone in vitro) overcome this inhibition to promote meiotic resumption. To test this model, we used G protei

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19

Jones, Barbara B., and Martin Petkovich. "Targeting Transcription through Nuclear Receptors." Current Pharmaceutical Design 2, no. 1 (1996): 155–68. http://dx.doi.org/10.2174/1381612802666220920221247.

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Abstract: It has long been known that the structural modification of steroid hormones can alter their biological activity. Some of these changes in activity are attributable to altered uptake and metabolism. With the cDNA cloning and characterization of nuclear receptors for steroids and related compounds, it has become possible to ascribe changes in ligand activity to specific alterations in receptor function. In this review we will discuss the steroid/thyroid hormone receptor superfamily, and how knowledge of receptor structures and mechanism of action may be exploited therapeutically to alt

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20

Ruka, Kristen A., Laura L. Burger та Suzanne M. Moenter. "Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice". Endocrinology 157, № 2 (2015): 752–63. http://dx.doi.org/10.1210/en.2015-1688.

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Abstract Gonadal steroids regulate the pattern of GnRH secretion. Arcuate kisspeptin (kisspeptin, neurokinin B, and dynorphin [KNDy]) neurons may convey steroid feedback to GnRH neurons. KNDy neurons increase action potential firing upon the activation of neurokinin B receptors (neurokinin-3 receptor [NK3R]) and decrease firing upon the activation of dynorphin receptors (κ-opioid receptor [KOR]). In KNDy neurons from intact vs castrated male mice, NK3R-mediated stimulation is attenuated and KOR-mediated inhibition enhanced, suggesting gonadal secretions are involved. Estradiol suppresses spont

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Chow, Renee W. Y., David J. Handelsman, and Martin K. C. Ng. "Minireview: Rapid Actions of Sex Steroids in the Endothelium." Endocrinology 151, no. 6 (2010): 2411–22. http://dx.doi.org/10.1210/en.2009-1456.

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The endothelium is a dynamic interface between the blood vessel and the circulating blood that plays a pivotal role in vascular homeostasis. As such, studies on sex steroid regulation of endothelial function are critical to understanding the role of sex steroids in cardiovascular health and disease. The classical model of steroid action involves liganded steroid receptors binding to specific response elements on target genes to regulate gene transcription. In whole organisms, the time lag between steroid administration and observable effects produced by newly synthesized protein is typically i

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WEIGEL, Nancy L. "Steroid hormone receptors and their regulation by phosphorylation." Biochemical Journal 319, no. 3 (1996): 657–67. http://dx.doi.org/10.1042/bj3190657.

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The steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors encompasses not only the receptors for steroids, thyroid hormone, retinoids and vitamin D, but also a large number of proteins whose functions and/or ligands are unknown and which are thus termed orphan receptors. Recent studies have highlighted the importance of phosphorylation in receptor function. Although most of the phosphorylation sites are serine and threonine residues, a few of the family members are also phosphorylated on tyrosine. Those steroid receptor family members that are bound to heat-sho

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Meikle, A., C. Tasende, C. Sosa, and E. G. Garófalo. "The role of sex steroid receptors in sheep female reproductive physiology." Reproduction, Fertility and Development 16, no. 4 (2004): 385. http://dx.doi.org/10.1071/rd04036.

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Cell responsiveness to steroid hormones is related to the number and affinity of its receptors, thus factors affecting steroid expression will influence tissue sensitivity and functionality. The present review discusses the role of oestrogen and progesterone receptors in sheep female reproductive physiology. The mechanism of steroid hormone action in the target cell is introduced first; the tissue distribution, physiological functions and regulation of oestrogen receptor subtypes and progesterone receptor isoforms in ruminants are reported. The role of steroid receptors in target tissues (with

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Picard, D. "Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling." Pure and Applied Chemistry 75, no. 11-12 (2003): 1743–56. http://dx.doi.org/10.1351/pac200375111743.

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Signaling pathways can be linear, but more complex patterns are common. Growth factors and many other extracellular signals cannot directly enter cells and transduce their information via membrane-bound receptors. In contrast, steroid receptors are members of the nuclear receptor superfamily and await their cognate hormones inside the cells. These two types of signaling pathways are extensively intertwined and crosstalk at many different levels. A wide range of extra- and intracellular signals, including a variety of growth factors, can activate the transcriptional activity of steroid receptor

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Bishop, J. Michael. "Steroid receptors: Oncogenes as hormone receptors." Nature 321, no. 6066 (1986): 112–13. http://dx.doi.org/10.1038/321112a0.

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Tejura, S., G. R. Rodgers, M. H. Dunion, M. A. Parsons, J. C. E. Underwood, and P. M. Ingleton. "Sex-steroid receptors in the diethylnitrosamine model of hepatocarcinogenesis: modifications by gonadal ablation and steroid replacement therapy." Journal of Molecular Endocrinology 3, no. 3 (1989): 229–37. http://dx.doi.org/10.1677/jme.0.0030229.

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ABSTRACT The results of this study confirm our previous report of increased androgen receptor expression in livers of female SUAH Wistar rats during development of liver tumours induced by diethylnitrosamine (DENA). In adult female rats not treated with DENA, removal of the ovary increased liver androgen receptor levels but testosterone did not further enhance the androgen receptor status of ovariectomized rats. In normal adult males the testis and/or testosterone maintained high levels of androgen receptors but oestrogen reduced them in castrated rats. Oestrogen receptor levels were not signi

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Das, Shampa, and Peter Thomas. "Pesticides Interfere with the Nongenomic Action of a Progestogen on Meiotic Maturation by Binding to its Plasma Membrane Receptor on Fish Oocytes." Endocrinology 140, no. 4 (1999): 1953–56. http://dx.doi.org/10.1210/endo.140.4.6781.

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Abstract Although many environmental contaminants disrupt endocrine function by binding to nuclear steroid receptors, it is not known whether they are capable of binding to steroid membrane receptors and interfering with nongenomic actions of steroids. The binding of several organochlorine pesticides to the plasma membrane receptor for the maturation-inducing steroid, 17,20β,21-trihydroxy-4-pregnen-3-one (20β-S), in the ovaries of spotted seatrout (Cynoscion nebulosus) was investigated in in vitro competition assays. Kepone and o,p′-DDD were competitive inhibitors of 20β-S binding and caused c

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Ide, Hiroki, and Hiroshi Miyamoto. "Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor." Disease Markers 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/840640.

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There is a substantial amount of preclinical or clinical evidence suggesting that steroid hormone receptor-mediated signals play a critical role in urothelial tumorigenesis and tumor progression. These receptors include androgen receptor, estrogen receptors, glucocorticoid receptor, progesterone receptor, vitamin D receptor, retinoid receptors, peroxisome proliferator-activated receptors, and others including orphan receptors. In particular, studies using urothelial cancer tissue specimens have demonstrated that elevated or reduced expression of these receptors as well as alterations of their

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Stephenson, G., and J. Funder. "Hippocampal and renal type I receptors are differentially regulated." American Journal of Physiology-Endocrinology and Metabolism 252, no. 4 (1987): E525—E529. http://dx.doi.org/10.1152/ajpendo.1987.252.4.e525.

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Previously, we have shown that renal mineralocorticoid receptors and hippocampal "corticosterone-perferring" sites have identical intrinsic steroid specificity in vitro. Others have shown that the aldosterone binding species in kidney and hippocampus have identical trypsin fragmentation patterns on isoelectric focusing. To further explore possible areas of identity, we determined levels of type I receptors in hippocampus, renal outer medulla cortex, and renal inner medulla papilla from 22 min to 16 days after adrenalectomy. Available type I sites in kidney fractions increased postadrenalectomy

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Cato, Laura, Antje Neeb, Myles Brown, and Andrew C. B. Cato. "Control of Steroid Receptor Dynamics and Function by Genomic Actions of the Cochaperones p23 and Bag-1L." Nuclear Receptor Signaling 12, no. 1 (2014): nrs.12005. http://dx.doi.org/10.1621/nrs.12005.

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Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures of which they themselves do not remain a part. Chaperones associate with a large and diverse set of cofactors termed cochaperones that regulate their function and specificity. Chaperones and cochaperones regulate the activity of several classes of signaling molecules, including steroid receptors. Upon binding ligand, steroid receptors interact with discrete nucleotide sequences within the nucleus to control the expression of diverse physiological

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Szczurowska, Ewa, Eszter Szánti-Pintér, Nikolai Chetverikov, Alena Randáková, Eva Kudová, and Jan Jakubík. "Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids." International Journal of Molecular Sciences 24, no. 1 (2022): 507. http://dx.doi.org/10.3390/ijms24010507.

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Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer’s disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases a

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Wendler, Alexandra, Elisabetta Baldi, Brian J. Harvey, Angel Nadal, Anthony Norman, and Martin Wehling. "Position Paper: Rapid responses to steroids: current status and future prospects." European Journal of Endocrinology 162, no. 5 (2010): 825–30. http://dx.doi.org/10.1530/eje-09-1072.

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Steroids exert their actions through several pathways. The classical genomic pathway, which involves binding of steroids to receptors and subsequent modulation of gene expression, is well characterized. Besides this, rapid actions of steroids have been shown to exist. Since 30 years, research on rapid actions of steroids is an emerging field of science. Today, rapid effects of steroids are well established, and are shown to exist for every type of steroid. The classical steroid receptors have been shown to be involved in rapid actions, but there is also strong evidence that unrelated structure

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Clairardin, Sandrine G., Ryan T. Paitz, and Rachel M. Bowden. "In ovo inhibition of steroid metabolism by bisphenol-A as a potential mechanism of endocrine disruption." Proceedings of the Royal Society B: Biological Sciences 280, no. 1769 (2013): 20131773. http://dx.doi.org/10.1098/rspb.2013.1773.

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During embryonic development, endogenous signals, for example steroid hormones, and exogenous signals, for example endocrine disrupting chemicals (EDCs), have the capacity to produce phenotypic effects that persist into adulthood. As the actions of steroids are mediated through the binding of steroid receptors, most studies of EDCs have assumed that they too elicit their effects by binding steroid receptors. We tested an alternative hypothesis, namely that EDCs elicit their effects during embryonic development by disrupting the metabolism of maternally derived steroids, thereby allowing matern

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Weigel, Nancy L., and Nicole L. Moore. "Kinases and protein phosphorylation as regulators of steroid hormone action." Nuclear Receptor Signaling 5, no. 1 (2007): nrs.05005. http://dx.doi.org/10.1621/nrs.05005.

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Although the primary signal for the activation of steroid hormone receptors is binding of hormone, there is increasing evidence that the activities of cell signaling pathways and the phosphorylation status of these transcription factors and their coregulators determine the overall response to the hormone. In some cases, enhanced cell signaling is sufficient to cause activation of receptors in medium depleted of steroids. Steroid receptors are targets for multiple kinases. Many of the phosphorylation sites contain Ser/Thr-Pro motifs implicating proline-directed kinases such as the cyclin-depend

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Levin, Ellis R. "Rapid signaling by steroid receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295, no. 5 (2008): R1425—R1430. http://dx.doi.org/10.1152/ajpregu.90605.2008.

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Steroid receptors transcribe genes that lead to important biological processes, including normal organ development and function, tissue differentiation, and promotion of oncogenic transformation. These actions mainly result from nuclear steroid receptor action. However, for 50 years, it has been known that rapid effects of steroid hormones occur and could result from rapid signal transduction. Examples of these effects include stress responses to secreted glucocorticoids, rapid actions of thyroid hormones in the heart, and acute uterine/vaginal responses to injected estrogen. These types of re

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Parker, Malcolm G. "Steroid and related receptors." Current Opinion in Cell Biology 5, no. 3 (1993): 499–504. http://dx.doi.org/10.1016/0955-0674(93)90016-j.

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Auricchio, Ferdinando. "Phosphorylation of steroid receptors." Journal of Steroid Biochemistry 32, no. 4 (1989): 613–22. http://dx.doi.org/10.1016/0022-4731(89)90397-x.

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Fuller, Peter J. "Steroid receptors as oncogenes?" Molecular and Cellular Endocrinology 59, no. 3 (1988): 161–64. http://dx.doi.org/10.1016/0303-7207(88)90099-8.

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Marugo, Mario, G. Torre, D. Bernasconi, L. Fazzuoli, S. Berta, and G. Giordano. "Thyroid and steroid receptors." Journal of Endocrinological Investigation 12, no. 8 (1989): 565–70. http://dx.doi.org/10.1007/bf03350762.

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Dougherty, John J., Raj K. Puri, and David O. Toft. "Phosphorylation of steroid receptors." Trends in Pharmacological Sciences 6 (January 1985): 83–85. http://dx.doi.org/10.1016/0165-6147(85)90034-3.

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Challa, Venkata R. "Steroid receptors in meningiomas." Surgical Neurology 28, no. 3 (1987): 232. http://dx.doi.org/10.1016/0090-3019(87)90142-x.

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Sheppard, Karen E. "II. Intestinal corticosteroid receptors." American Journal of Physiology-Gastrointestinal and Liver Physiology 282, no. 5 (2002): G742—G746. http://dx.doi.org/10.1152/ajpgi.00531.2001.

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Two corticosteroid receptors have been cloned; they are the glucocorticoid receptor and the mineralocorticoid receptor. These receptors are members of the steroid/thyroid/retinoid receptor family of nuclear transactivating factors, which are characterized by two highly conserved zinc fingers in the central DNA binding domain, a COOH-terminal domain that encompasses the ligand binding site, and a variable NH2-terminal domain. In addition to these cloned receptors, other corticosteroid receptors have recently been identified in intestine. Steroid binding studies have identified two novel putativ

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Zheng, Yingfeng, and Leigh C. Murphy. "Regulation of Steroid Hormone Receptors and Coregulators during the Cell Cycle Highlights Potential Novel Function in Addition to Roles as Transcription Factors." Nuclear Receptor Signaling 14, no. 1 (2016): nrs.14001. http://dx.doi.org/10.1621/nrs.14001.

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Cell cycle progression is tightly controlled by several kinase families including Cyclin-Dependent Kinases, Polo-Like Kinases, and Aurora Kinases. A large amount of data show that steroid hormone receptors and various components of the cell cycle, including cell cycle regulated kinases, interact, and this often results in altered transcriptional activity of the receptor. Furthermore, steroid hormones, through their receptors, can also regulate the transcriptional expression of genes that are required for cell cycle regulation. However, emerging data suggest that steroid hormone receptors may h

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Keigley, Quinton J., Amy M. Fowler, Sophia R. O'Brien, and Farrokh Dehdashti. "Molecular Imaging of Steroid Receptors in Breast Cancer." Cancer Journal 30, no. 3 (2024): 142–52. http://dx.doi.org/10.1097/ppo.0000000000000715.

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Abstract Steroid receptors regulate gene expression for many important physiologic functions and pathologic processes. Receptors for estrogen, progesterone, and androgen have been extensively studied in breast cancer, and their expression provides prognostic information as well as targets for therapy. Noninvasive imaging utilizing positron emission tomography and radiolabeled ligands targeting these receptors can provide valuable insight into predicting treatment efficacy, staging whole-body disease burden, and identifying heterogeneity in receptor expression across different metastatic sites.

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Savory, Joanne G. A., Gratien G. Préfontaine, Claudia Lamprecht, et al. "Glucocorticoid Receptor Homodimers and Glucocorticoid-Mineralocorticoid Receptor Heterodimers Form in the Cytoplasm through Alternative Dimerization Interfaces." Molecular and Cellular Biology 21, no. 3 (2001): 781–93. http://dx.doi.org/10.1128/mcb.21.3.781-793.2001.

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ABSTRACT Steroid hormone receptors act to regulate specific gene transcription primarily as steroid-specific dimers bound to palindromic DNA response elements. DNA-dependent dimerization contacts mediated between the receptor DNA binding domains stabilize DNA binding. Additionally, some steroid receptors dimerize prior to their arrival on DNA through interactions mediated through the receptor ligand binding domain. In this report, we describe the steroid-induced homomeric interaction of the rat glucocorticoid receptor (GR) in solution in vivo. Our results demonstrate that GR interacts in solut

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Ma, Zhi-Qing, Zheng Liu, Elly S. W. Ngan, and Sophia Y. Tsai. "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors." Molecular and Cellular Biology 21, no. 23 (2001): 8056–67. http://dx.doi.org/10.1128/mcb.21.23.8056-8067.2001.

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ABSTRACT We have previously demonstrated that overexpression of Cdc25B in transgenic mice resulted in mammary gland hyperplasia and increased steroid hormone responsiveness. To address how Cdc25B enhances the hormone responsiveness in mammary glands, we showed that Cdc25B stimulates steroid receptor-dependent transcription in transient transfection assays and in a cell-free assay with chromatin templates. Surprisingly, the effect of Cdc25B on steroid receptors is independent of its protein phosphatase activity in vitro. The direct interactions of Cdc25B with steroid receptors, on the other han

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Branković-Magić, M., Z. Nešković-Konstantinović, D. Nikolić-Vukosavljević, and I. Spužić. "Steroid receptors in pleural effusions of advanced breast cancer patients." International Journal of Biological Markers 10, no. 3 (1995): 143–48. http://dx.doi.org/10.1177/172460089501000303.

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The steroid receptor content in breast carcinoma correlates with the responsiveness of malignant cells to endocrine manipulation. Although the steroid receptor status of the primary tumor is mostly used to select systemic therapy, it was suggested that steroid receptor content should be evaluated in metastatic lesions whenever possible. In this study the estrogen and progesterone receptor content was determined biochemically in 38 pleural effusions from advanced breast cancer patients. In 17/38 patients the steroid receptor status was assessed twice during the course of the disease - at diagno

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Fliss, Albert E., Yifang Fang, Frank Boschelli, and Avrom J. Caplan. "Differential In Vivo Regulation of Steroid Hormone Receptor Activation by Cdc37p." Molecular Biology of the Cell 8, no. 12 (1997): 2501–9. http://dx.doi.org/10.1091/mbc.8.12.2501.

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The CDC37 gene is essential for the activity of p60v-src when expressed in yeast cells. Since the activation pathway for p60v-src and steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37

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Fannon, Stacey A., Regina M. Vidaver, and Sherry A. Marts. "Historical Perspectives: An abridged history of sex steroid hormone receptor action." Journal of Applied Physiology 91, no. 4 (2001): 1854–59. http://dx.doi.org/10.1152/jappl.2001.91.4.1854.

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The field of steroid hormone action is well established, although it is barely more than four decades old. Pivotal experiments in the late 1950s and 1960s showed that hormone-binding components exist within nuclei of target tissues and that steroid hormones act by regulating gene expression, rather than directly influencing enzymatic processes. The understanding that steroid hormone receptors interact with the general transcription machinery and alter chromatin structure came in the 1970s and 1980s, and details of this mechanism continue to be elucidated. In addition, the discovery of rapid ce

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Moore, R. L., Y. Dai, and D. V. Faller. "Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer." Journal of Endocrinology 213, no. 1 (2011): 37–48. http://dx.doi.org/10.1530/joe-11-0217.

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Sirtuins, which are class III NAD-dependent histone deacetylases that regulate a number of physiological processes, play important roles in the regulation of metabolism, aging, oncogenesis, and cancer progression. Recently, a role for the sirtuins in the regulation of steroid hormone receptor signaling is emerging. In this mini-review, we will summarize current research into the regulation of estrogen, androgen, progesterone, mineralocorticoid, and glucocorticoid signaling by sirtuins in cancer. Sirtuins can regulate steroid hormone signaling through a variety of molecular mechanisms, includin

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