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Artykuły w czasopismach na temat „Stimulation cellulaire”

Autor: Grafiati

Data publikacji: 8 czerwca 2024

Data aktualizacji: 31 lipca 2025

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1

Abdoul-Azize, Souleymane. "La stimulation cellulaire liée aux glucocorticoïdes." médecine/sciences 41, no. 3 (2025): 226–28. https://doi.org/10.1051/medsci/2025030.

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Carmen Martínez, Maria, Corinne Kunzelmann, and Jean-Marie Freyssinet. "Remodelage de la membrane plasmique et stimulation cellulaire." médecine/sciences 20, no. 2 (2004): 189–95. http://dx.doi.org/10.1051/medsci/2004202189.

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Vallée, Alexandre. "Activation de la glycolyse aérobie par la voie canonique WNT/β-caténine". médecine/sciences 34, № 4 (2018): 326–30. http://dx.doi.org/10.1051/medsci/20183404013.

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L’énergie est le principal facteur déterminant de la viabilité neuronale. Dans cette synthèse, nous proposons l’hypothèse d’une activation anormale de la glycolyse aérobie par la stimulation de la voie de signalisation canonique WNT/β-caténine dans la sclérose latérale amyotrophique (SLA). La stimulation de la voie canonique WNT induit en effet l’activation de la glycolyse aérobie, appelée aussi effet Warburg, via la stimulation des enzymes glycolytiques comme PKM2, PDK1, LDH-A et MCT-1 et les transporteurs de glucose Glut. La glycolyse aérobie consiste en la conversion de la majeure partie du

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Mollard, Patrice. "L’hypophyse dévoilée : du couplage stimulation-sécrétion aux réseaux cellulaires câblant la glande." Biologie Aujourd’hui 216, no. 3-4 (2022): 83–87. http://dx.doi.org/10.1051/jbio/2022021.

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L’année 2021 s’est terminée par un événement de grande tristesse : le décès d’Andrée Tixier-Vidal. Elle fut non seulement une pionnière en biologie cellulaire mais également la promotrice charismatique de fédérations collaboratives multidisciplinaires particulièrement stimulantes et fructueuses. Cette note en retrace les succès en termes de découvertes à la fois sur le couplage stimulation-sécrétion des cellules endocrines de l’hypophyse et sur l’organisation de ces cellules hypophysaires en réseaux 3D multicellulaires à l’origine des sécrétions pulsées des hormones hypophysaires qui contrôlen

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5

SEYER, P., S. GRANDEMANGE, L. PESSEMESSE, F. CASAS, G. CABELLO, and C. WRUTNIAK-CABELLO. "L’activité mitochondriale est un régulateur majeur de la différenciation des myoblastes et de l’expression des isoformes de myosine." INRAE Productions Animales 19, no. 4 (2006): 279–86. http://dx.doi.org/10.20870/productions-animales.2006.19.4.3495.

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Parallèlement à son rôle dans le métabolisme énergétique, l’activité mitochondriale intervient également dans l’induction de l’apoptose, ainsi que dans la régulation de la prolifération et de la différenciation cellulaires. Il existe en particulier une véritable régulation de la différenciation des myoblastes par l’activité mitochondriale, indépendante de la production d’ATP. Elle implique notamment le contrôle de l’expression de myogénine et de l’activité des facteurs myogéniques. Dans cette étude, nous démontrons que l’expression du proto-oncogène c-Myc est respectivement stimulée ou d

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Gruffat, Henri, and Evelyne Manet. "Co-infection EBV/KSHV." médecine/sciences 34, no. 1 (2018): 79–82. http://dx.doi.org/10.1051/medsci/20183401017.

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Le virus herpétique humain associé au sarcome de Kaposi (KSHV) est l’agent étiologique du lymphome primitif des séreuses (PEL) dans lequel le virus d’Epstein-Barr (EBV) est aussi très souvent présent. Jusqu’à présent, seuls des modèles cellulaires permettaient d’explorer l’interaction des deux virus conduisant à la transformation des cellules. Un modèle de co-infection de souris humanisées, développé récemment permet désormais d’explorer ce phénomène in vivo. Il démontre que la co-infection par EBV et par KSHV augmente la persistance de KSHV et favorise la transformation cellulaire via la stim

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7

Kahn, A. "MAP-kinase, un intégrateur possible des différentes voies de stimulation de la division cellulaire." médecine/sciences 6, no. 4 (1990): 392. http://dx.doi.org/10.4267/10608/4154.

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Dumond, Aurore, Luc Demange, and Gilles Pagès. "Les neuropilines." médecine/sciences 36, no. 5 (2020): 487–96. http://dx.doi.org/10.1051/medsci/2020080.

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Une angiogenèse exacerbée est une des caractéristiques (« hallmarks ») du cancer, définies par Hanahan et Weinberg1. Cependant, le ciblage de la voie de signalisation du VEGF (vascular endothelial growth factor) ou de ses récepteurs a montré ses limites thérapeutiques. Après un bénéfice thérapeutique indéniable pour les patients, les tumeurs récidivent après quelques mois, et deviennent généralement métastatiques et incurables. Les neuropilines 1 et 2 (NRP1, 2) dont l’activité a été décrite initialement dans le système nerveux, stimulent de nombreuses fonctions impliquées dans l’agressivité tu

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9

Gur, Serap, and Wayne J. G. Hellstrom. "Activation of P2Y1 and P2Y2 nucleotide receptors by adenosine 5′-triphosphate analogues augmented nerve-mediated relaxation of human corpus cavernosum." Canadian Urological Association Journal 3, no. 4 (2013): 314. http://dx.doi.org/10.5489/cuaj.1127.

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Introduction: Adenosine 5′-triphosphate (ATP) is a ubiquitous cellularenergy source. We evaluated the effect of ATP and its analogueson nonadrenergic and noncholinergic relaxation in precontractedhuman corpus cavernosal smooth muscle (HCCSM).Methods: We obtained specimens of human corpus cavernosum(HCC) from patients undergoing penile prosthesis surgery (patientage 46–70 yr, n = 17) with prior approval from the local institutionalreview board. Isolated HCC strips were placed in organbaths containing Krebs solution and functional experiments wereconducted. Immunohistochemical localization studi

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10

Crémoux, P., F. Calvo, C. Gauville, G. Lagier, and JP Abila. "STIMULATION PAR LA 1, 25 DIHYDROXYVITAMINE D3 (1, 25 (OH) 2 D3) DE L'ACTIVITE ADENYLATE CYCLASE DES CELLULES DE CANCER DU SEIN HUMAIN (T47D): MODE D'ACTION ET EFFET SUR LA PROLIFERATION CELLULAIRE." Reproduction Nutrition Développement 29, Suppl. 1 (1989): 9. http://dx.doi.org/10.1051/rnd:19890710.

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11

Danilov, Igor Val. "The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation Techniques." OBM Neurobiology 08, no. 04 (2024): 1–23. http://dx.doi.org/10.21926/obm.neurobiol.2404260.

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This narrative review of the literature on noninvasive brain stimulation techniques observes four neurostimulation domains: light therapy, photobiomodulation, a group of techniques within transcranial electric current and magnetic field stimulations, low-frequency sound stimulations, including vibroacoustic therapy, and rhythmic auditory stimulation. The review aims to determine whether or not different brain stimulation approaches rely upon a similar physicochemical sequence of actions. The study identifies relevant hypotheses about processes at the cellular level underlying noninvasive brain

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12

Lin, James C. A., Jimmy K. Li, and Walter H. Chang. "Signal Transduction Pathway of Ultrasound Stimulation on Osteoblasts(Cellular & Tissue Engineering)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2004.1 (2004): 87–88. http://dx.doi.org/10.1299/jsmeapbio.2004.1.87.

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Chang, Walter H., Jimmy K. Li, and James C. A. Lin. "Biological Response of Low Intensity Ultrasound Stimulation on Osteoblasts(Cellular & Tissue Engineering)." Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics 2004.1 (2004): 89–90. http://dx.doi.org/10.1299/jsmeapbio.2004.1.89.

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Di, Ya-Li, Xiao-Ming Lu, Zu-Qing Zhu, and Fu-Xing Zhu. "Time Course of Carbendazim Stimulation on Pathogenicity of Sclerotinia sclerotiorum Indicates a Direct Stimulation Mechanism." Plant Disease 100, no. 7 (2016): 1454–59. http://dx.doi.org/10.1094/pdis-11-15-1349-re.

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Previous studies have demonstrated that subtoxic doses of carbendazim have a stimulatory effect on pathogenicity of Sclerotinia sclerotiorum on rapeseed plants. The present study focused on the time-course profile of the stimulatory effect and its relevance to stimulation mechanisms. At 12 h postinoculation (HPI), initial necrotic lesions were visible only for rapeseed leaves treated with carbendazim at 0.2 and 1 μg/ml, whereas no disease symptoms were observed for the nontreated control. At 18 HPI, carbendazim stimulation on pathogenicity was more obvious than at 12 HPI. Study with scanning e

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15

Vilkhu, Ramandeep S., Sasidhar S. Madugula, Lauren E. Grosberg, et al. "Spatially patterned bi-electrode epiretinal stimulation for axon avoidance at cellular resolution." Journal of Neural Engineering 18, no. 6 (2021): 066007. http://dx.doi.org/10.1088/1741-2552/ac3450.

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Abstract Objective. Epiretinal prostheses are designed to restore vision to people blinded by photoreceptor degenerative diseases by stimulating surviving retinal ganglion cells (RGCs), which carry visual signals to the brain. However, inadvertent stimulation of RGCs at their axons can result in non-focal visual percepts, limiting the quality of artificial vision. Theoretical work has suggested that axon activation can be avoided with current stimulation designed to minimize the second spatial derivative of the induced extracellular voltage along the axon. However, this approach has not been v

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16

Prebet, Thomas, Quoc-Hung Le, Jean-Michel Boiron, et al. "Impact of Hematopoietic Stem Cell (HSC) Recruitment and Graft Composition on Transplant Outcome after Reduced Intensity Allogeneic Peripheral Blood Stem Cell Transplantation (PBSCT): A Study of the Société Française de Greffe de Moelle Osseuse et de Thérapie Cellulaire (SFGM-TC) Registry." Blood 106, no. 11 (2005): 1146. http://dx.doi.org/10.1182/blood.v106.11.1146.1146.

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Abstract Evidence of an impact of graft product on transplant outcome after PBSCT is actually rising. Here, we investigated retrospectively the potential impact of HSC recruitment procedure (i.e. G-CSF stimulation schedule and apheresis number) and graft composition (CD34+ and CD3+ cell number) on transplant outcome (GVHD, OS, EFS). Our analysis concerned 488 HLA matched sibling allogeneic reduced intensity conditioning (RIC) PBSCT for hematological malignancies (116 MM, 110 AML, 109 NHL, 41 CLL, 41 MDS, 24 CML, 19 HD, 17 ALL and 11 MPS) reported on the SFGM-TC registry between 1998 and 2004.

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Zalkhani, Raha, Ahmad Ali Moazedi, Zohreh Ghotbeddin, and Mahdi Pourmahdi Borujeni. "Interaction of Sodium Valproate With Low-Frequency Electrical Stimulation During Kindlingn." Basic and Clinical Neuroscience Journal 11, no. 6 (2020): 831–40. http://dx.doi.org/10.32598/bcn.11.6.1392.2.

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Introduction: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control seizures in patients with pharmacoresistance to drugs. So, the present study aimed to design to determine the effect of a subeffective dose of sodium valproate combined with low-frequency electrical stimulation during kindling. Methods: One tripolar electrode was implanted stereotactically in the CA1 hippocampus of male Wistar rats. One week after surgery, the rats were kindled by electrical stimulation of hippocampus in a rapid manner (12 stimulations/day) for 6 days wi

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18

Whisenant, N., B. X. Zhang, M. Khademazad, P. Loessberg, and S. Muallem. "Regulation of Na-K-2Cl cotransport in osteoblasts." American Journal of Physiology-Cell Physiology 261, no. 3 (1991): C433—C440. http://dx.doi.org/10.1152/ajpcell.1991.261.3.c433.

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Uptake of 86Rb was used to follow the activity of Na-K-2Cl cotransport in the osteosarcoma cell line UMR-106-01. The ouabain-resistant fraction of 86Rb uptake was sensitive to bumetanide and furosemide. Furosemide-sensitive 86Rb uptake required the presence of Na+, K+, and Cl- in the incubation medium. These observations indicate the presence of a Na-K-2Cl cotransport system in osteoblasts. Cotransporter activity was stimulated by agonists which increase adenosine 3',5'-cyclic monophosphate (cAMP), cytosolic free Ca2+ ([Ca2+]i), and protein kinase C (PKC) activity such as parathyroid hormone (

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19

Jia, Ying, Junmei Zhang, Bo Chen, et al. "Strain Stimulations with Different Intensities on Fibroblast Viability and Protein Expression." Open Life Sciences 12, no. 1 (2017): 285–93. http://dx.doi.org/10.1515/biol-2017-0033.

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AbstractBackgroundMechanical stimulation via acupuncture and tuina massage triggers various cell responses. This study aims to understand these cellular bio-physical mechanisms by investigating the effect of different stimulation intensities on cell viability and protein expression.MethodologyConnective tissue fibroblasts were cultured in vitro. Three varying intensities of mechanical strain stimulation were applied to the cells, either once or three times and compared with non-stimulated controls. Changes in fibroblast viability and fibroblast protein expression were observed.ResultsStrain st

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Xiao, Guihua, Yilin Song, Yu Zhang, et al. "Dopamine and Striatal Neuron Firing Respond to Frequency-Dependent DBS Detected by Microelectrode Arrays in the Rat Model of Parkinson’s Disease." Biosensors 10, no. 10 (2020): 136. http://dx.doi.org/10.3390/bios10100136.

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(1) Background: Deep brain stimulation (DBS) is considered as an efficient treatment method for alleviating motor symptoms in Parkinson’s disease (PD), while different stimulation frequency effects on the specific neuron patterns at the cellular level remain unknown. (2) Methods: In this work, nanocomposites-modified implantable microelectrode arrays (MEAs) were fabricated to synchronously record changes of dopamine (DA) concentration and striatal neuron firing in the striatum during subthalamic nucleus DBS, and different responses of medium spiny projecting neurons (MSNs) and fast spiking int

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Lee, YY, I. Kurtz, K. Yamato, Z. el-Hajjoui, and HP Koeffler. "Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation." Blood 79, no. 9 (1992): 2262–66. http://dx.doi.org/10.1182/blood.v79.9.2262.2262.

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Abstract Several hormones and cytokines stimulate the cellular Na+/H+ antiporter and this stimulation may be a signal transduction mechanism to mediate gene expression. We find that tumor necrosis factor rapidly stimulates both the Na+/H+ antiporter and the accumulation of mRNA coding for granulocyte-macrophage colony-stimulating factor and interleukin-6 in fibroblasts. Further experiments show that these phenomena occur independent of each other.

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Lee, YY, I. Kurtz, K. Yamato, Z. el-Hajjoui, and HP Koeffler. "Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation." Blood 79, no. 9 (1992): 2262–66. http://dx.doi.org/10.1182/blood.v79.9.2262.bloodjournal7992262.

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Several hormones and cytokines stimulate the cellular Na+/H+ antiporter and this stimulation may be a signal transduction mechanism to mediate gene expression. We find that tumor necrosis factor rapidly stimulates both the Na+/H+ antiporter and the accumulation of mRNA coding for granulocyte-macrophage colony-stimulating factor and interleukin-6 in fibroblasts. Further experiments show that these phenomena occur independent of each other.

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Kachadorian, W. A., J. Muller, and V. A. DiScala. "Variability of cellular responsiveness to ADH stimulation in toad urinary bladder." American Journal of Physiology-Renal Physiology 256, no. 4 (1989): F590—F595. http://dx.doi.org/10.1152/ajprenal.1989.256.4.f590.

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The hydrosmotic response of toad bladder to antidiuretic hormone (ADH) is quantitatively linked to the induced fusion of aggrephores with, and the appearance of aggregates of tightly packed intramembrane particles in the luminal membrane of granular cells. We used these morphological indexes of hormonally induced cell activation 1) to assess the variability of individual cell responsiveness to a maximally stimulating concentration of ADH and 2) to compare cell response patterns in paired tissues where the extent of whole tissue stimulation, as evidenced by transtissue water flow, was either ma

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Song, Shijie, Shuojing Song, Chuanhai Cao, et al. "Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle." Stem Cells International 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/205878.

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We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to micro

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Huang, Xin, Zhengxiang Huang, Weidong Gao, et al. "Current Advances in 3D Dynamic Cell Culture Systems." Gels 8, no. 12 (2022): 829. http://dx.doi.org/10.3390/gels8120829.

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The traditional two-dimensional (2D) cell culture methods have a long history of mimicking in vivo cell growth. However, these methods cannot fully represent physiological conditions, which lack two major indexes of the in vivo environment; one is a three-dimensional 3D cell environment, and the other is mechanical stimulation; therefore, they are incapable of replicating the essential cellular communications between cell to cell, cell to the extracellular matrix, and cellular responses to dynamic mechanical stimulation in a physiological condition of body movement and blood flow. To solve the

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Zhu, Ercheng, Alain S. Comtois, Liwei Fang, Norman R. Comtois, and Alejandro E. Grassino. "Influence of tension time on muscle fiber sarcolemmal injury in rat diaphragm." Journal of Applied Physiology 88, no. 1 (2000): 135–41. http://dx.doi.org/10.1152/jappl.2000.88.1.135.

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We hypothesized that the amount of sarcolemmal injury is directly related to the total tension time (TTtot), calculated as mean tension × total stimulation time. Diaphragm strips from Sprague-Dawley rats were superfused at optimal muscle length with Krebs containing procion orange to identify sarcolemmal injury. TTtot was induced by stimulation with 100 Hz for 3 min at duty cycles of 0.02, 0.15, 0.3, and 0.6, or with continuous contractions at 0.2, 0.4, 0.6, and 1.0 of maximal tension. A significant positive correlation between TTtot and the percentage of fibers with injured sarcolemma ( r 2 =

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Chen, Yafen, Yoon-Hee Cha, Diamond Gleghorn, et al. "Brain network effects by continuous theta burst stimulation in mal de débarquement syndrome: simultaneous EEG and fMRI study." Journal of Neural Engineering 18, no. 6 (2021): 066025. http://dx.doi.org/10.1088/1741-2552/ac314b.

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Abstract Objective. Heterogeneous clinical responses to treatment with non-invasive brain stimulation are commonly observed, making it necessary to determine personally optimized stimulation parameters. We investigated neuroimaging markers of effective brain targets of treatment with continuous theta burst stimulation (cTBS) in mal de débarquement syndrome (MdDS), a balance disorder of persistent oscillating vertigo previously shown to exhibit abnormal intrinsic functional connectivity. Approach. Twenty-four right-handed, cTBS-naive individuals with MdDS received single administrations of cTBS

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Whitlock, D. M., and R. L. Terjung. "ATP depletion in slow-twitch red muscle of rat." American Journal of Physiology-Cell Physiology 253, no. 3 (1987): C426—C432. http://dx.doi.org/10.1152/ajpcell.1987.253.3.c426.

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Rat slow-twitch muscle, in contrast to fast-twitch muscle, maintains its ATP content near normal during intense stimulation conditions that produce rapid fatigue. An extensive depletion of adenine nucleotide content by the deamination of AMP to IMP + NH3, typical of fast-twitch muscle, does not occur. We evaluated whether this response of slow-twitch muscle could be simply due to failure of synaptic transmission or related to cellular conditions influencing enzyme activity. Stimulation of soleus muscles in situ via the nerve or directly in the presence of curare at 120 tetani/min for 3 min res

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Takanezawa, Sota, Shin-ichi Morita, Yukihiro Ozaki, and Yasushi Sako. "2P199 Raman Micro-spectroscopy of the Dynamics of Cellular Chemical State upon Stimulation with Growth Factors(12. Cell biology,Poster)." Seibutsu Butsuri 54, supplement1-2 (2014): S228. http://dx.doi.org/10.2142/biophys.54.s228_1.

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Umashankar, Abishek, and Prashanth Prabhu. "The application of vagus nerve stimulation in individuals with misophonia." Neuroscience Research Notes 3, no. 5 (2021): 36–43. http://dx.doi.org/10.31117/neuroscirn.v3i5.105.

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Stimulating the Vagus nerve helps maintain the autonomic tone, indicating stabilising any hyperactivity in the nervous system. The vagus nerve stimulation is applied in individuals with seizures, depression, sepsis, pain, obesity, cardiovascular disease, lung disease, diabetes, stroke, and traumatic brain injury. Auditory neuroscience has been widely applied in individuals with tinnitus and has been demonstrated as a successful neuromodulation technique. Individuals with peripheral lesions of the hair cells induce a maladaptive change in the plasticity resulting in hyperactivity in the auditor

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Yang, Hong, Gerry Shaw, and Mohan K. Raizada. "ANG II stimulation of neuritogenesis involves protein kinase B in brain neurons." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283, no. 1 (2002): R107—R114. http://dx.doi.org/10.1152/ajpregu.00611.2001.

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Stimulation of the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB) signal transduction pathway has been linked to the neuromodulatory action of ANG II in the brain neurons of the spontaneously hypertensive rat (Yang H and Raizada MK. J Neurosci 19: 2413–2423, 1999). The cellular consequences of this signaling pathway, however, remain unknown in the brain neurons from the normotensive rat. The present study was designed to test the hypothesis that the PI3K-PKB signaling cascade activates an ANG II-mediated neuritogenic action by stimulating cellular growth-associated protein-43 (GAP

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Downing, J. R., C. W. Rettenmier, and C. J. Sherr. "Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line." Molecular and Cellular Biology 8, no. 4 (1988): 1795–99. http://dx.doi.org/10.1128/mcb.8.4.1795-1799.1988.

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Metabolic labeling of simian virus 40-immortalized murine macrophages with 32Pi and immunoblotting with antibodies to phosphotyrosine demonstrated that the c-fms proto-oncogene product (colony-stimulating factor 1 [CSF-1] receptor) was phosphorylated on tyrosine in vivo and rapidly degraded in response to CSF-1. Stimulation of the CSF-1 receptor also induced immediate phosphorylation of several other cellular proteins on tyrosine. By contrast, the mature cell surface glycoprotein encoded by the v-fms oncogene was phosphorylated on tyrosine in the absence of CSF-1, suggesting that it functions

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Downing, J. R., C. W. Rettenmier, and C. J. Sherr. "Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line." Molecular and Cellular Biology 8, no. 4 (1988): 1795–99. http://dx.doi.org/10.1128/mcb.8.4.1795.

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Metabolic labeling of simian virus 40-immortalized murine macrophages with 32Pi and immunoblotting with antibodies to phosphotyrosine demonstrated that the c-fms proto-oncogene product (colony-stimulating factor 1 [CSF-1] receptor) was phosphorylated on tyrosine in vivo and rapidly degraded in response to CSF-1. Stimulation of the CSF-1 receptor also induced immediate phosphorylation of several other cellular proteins on tyrosine. By contrast, the mature cell surface glycoprotein encoded by the v-fms oncogene was phosphorylated on tyrosine in the absence of CSF-1, suggesting that it functions

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Rosenberg, Nahum. "The role of the cytoskeleton in mechanotransduction in human osteoblastlike cells." Human & Experimental Toxicology 22, no. 5 (2003): 271–74. http://dx.doi.org/10.1191/0960327103ht362oa.

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The regulation of osteoblast proliferation is a key factor in maintaining bone mass. The enhancement of this process can be achieved by stimulating the proliferation of these cells. Mechanical stimulation is one of the important enhancing factors, but the exact cellular mechanisms of mechanical stimulation, i.e., mechanotransduction, are unknown. In order to investigate the role of the cytoskeleton components in mechanotransduction for cell proliferation, I compared the total DNA content in cultured replicates of osteoblast-like cells derived from three human donors following their exposure to

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Westerblad, H., J. A. Lee, J. Lannergren, and D. G. Allen. "Cellular mechanisms of fatigue in skeletal muscle." American Journal of Physiology-Cell Physiology 261, no. 2 (1991): C195—C209. http://dx.doi.org/10.1152/ajpcell.1991.261.2.c195.

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Prolonged activation of skeletal muscle leads to a decline of force production known as fatigue. In this review we outline the ionic and metabolic changes that occur in muscle during prolonged activity and focus on how these changes might lead to reduced force. We discuss two distinct types of fatigue: fatigue due to continuous high-frequency stimulation and fatigue due to repeated tetanic stimulation. The causes of force decline are considered under three categories: 1) reduced Ca2+ release from the sarcoplasmic reticulum, 2) reduced myofibrillar Ca2+ sensitivity, and 3) reduced maximum Ca(2+

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Levy, Estrella Mariel, María Paula Roberti, and José Mordoh. "Natural Killer Cells in Human Cancer: From Biological Functions to Clinical Applications." Journal of Biomedicine and Biotechnology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/676198.

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Natural killer (NK) cells are central components of the innate immunity. In murine models, it has been shown that NK cells can control both local tumor growth and metastasis due to their ability to exert direct cellular cytotoxicity without prior sensitization and to secrete immunostimulatory cytokines like IFN-γ. The latter participates in cancer elimination by inhibiting cellular proliferation and angiogenesis, promoting apoptosis, and stimulating the adaptive immune system, and it is instrumental for enhancing Ag processing and presentation. Nevertheless, NK cells display impaired functiona

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Hooper, S. L., and M. Moulins. "Cellular and synaptic mechanisms responsible for a long-lasting restructuring of the lobster pyloric network." Journal of Neurophysiology 64, no. 5 (1990): 1574–89. http://dx.doi.org/10.1152/jn.1990.64.5.1574.

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1. In the lobster Palinurus vulgaris a sensory input in the lateral posterolateral nerve (lpln) of the stomatogastric nervous system (STS) is able to turn on the cardiac sac (CS) network and to induce dramatic long-lasting alterations in the output of the pyloric network. This long-lasting alteration of pyloric network output consists primarily of changes in the activity of the two neurons that innervate the muscles of the cardiopyloric valve of the stomach, with the dilator neuron (the ventricular dilator, VD) transferring from the pyloric network to the CS network and the constrictor neuron

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Woller, Michael J., Gary T. Campbell, and Charles A. Blake. "Induction of Cellular Follicle-Stimulating Hormone in the Hamster Adenohypophysis Requires Intermittent Stimulation by Luteinizing Hormone Releasing Hormone." Journal of Neuroendocrinology 7, no. 5 (1995): 393–400. http://dx.doi.org/10.1111/j.1365-2826.1995.tb00774.x.

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Marks, J. D., D. F. Donnelly, and G. G. Haddad. "Adenosine-induced inhibition of vagal motoneuron excitability: receptor subtype and mechanisms." American Journal of Physiology-Lung Cellular and Molecular Physiology 264, no. 2 (1993): L124—L132. http://dx.doi.org/10.1152/ajplung.1993.264.2.l124.

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With the use of intracellular techniques and a medullary slice preparation, we examined the changes in cellular and membrane properties of single adult rat vagal motoneurons during exposure to potent and specific agonists and antagonists of adenosine A1 and A2 receptors. A1 receptor stimulation increased input resistance, but markedly reduced spontaneous neuronal firing and increased rheobase. A1 agonists also increased the amplitude of the action potential afterhyperpolarization (AHP) in a dose-dependent manner. Prior treatment with A1 antagonists blocked these electrophysiological effects. B

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Borsuk, Daria, Maryna Bondarenko, and Olga Zaytseva. "TRANSCRANIAL NEAR-INFRARED THERAPY FOR COGNITIVE PERFORMANCE AND NEUROLOGICAL STATUS ENHANCEMENT." Grail of Science, no. 36 (February 26, 2024): 447–52. http://dx.doi.org/10.36074/grail-of-science.16.02.2024.078.

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There is a growing interest in non-invasive treatment options in the field of neurotherapy with transcranial near-infrared (tNIR) light demonstrating promising results across a broad spectrum of neurological disorders. This paper explores the therapeutic potential of tNIR and its efficacy in stimulating cellular functions to improve outcomes in neurodegenerative diseases such as dementia, Parkinson’s disease, Alzheimer’s disease as well as traumatic brain injury, stroke recovery, neuroinflammatory conditions, depression, and BDNF stimulation. Through the direct transcranial application of low-

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Puissant, C., M. Bayat-Sarmadi, E. Devinoy, and L.-M. Houdebine. "Variation of transferrin mRNA concentration in the rabbit mammary gland during the pregnancy–lactation–weaning cycle and in cultured mammary cells. A comparison with the other major milk protein mRNAs." European Journal of Endocrinology 130, no. 5 (1994): 522–29. http://dx.doi.org/10.1530/eje.0.1300522.

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Puissant C, Bayat-Sarmadi M, Devinoy E, Houdebine L-M. Variation of transferrin mRNA concentration in the rabbit mammary gland during the pregnancy–lactation–weaning cycle and in cultured mammary cells. A comparison with the other major milk protein mRNAs. Eur J Endocrinol 1994;130:522–9. ISSN 0804–4643 The concentration of transferrin mRNA was evaluated during pregnancy and lactation in rabbit mammary gland and liver using northern blot and dot blot assays. Transferrin mRNA was present in the virgin rabbit mammary gland and its concentration increased as pregnancy proceeded, with a major enha

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Ariel, M., and T. X. Fan. "Electrophysiological evidence for a bisynaptic retinocerebellar pathway." Journal of Neurophysiology 69, no. 4 (1993): 1323–30. http://dx.doi.org/10.1152/jn.1993.69.4.1323.

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1. Electrical microstimulation was applied to an in vitro turtle brain preparation while recording extracellular activity from the cerebellar cortex. A visual input to the cerebellum was investigated by measuring spike responses evoked by stimulation of drifting visual patterns imaged onto the contralateral retinal eyecup. A vestibular input was assessed by extracellular field potentials following brief current pulses through monopolar suction electrodes holding the eighth cranial nerve (nVIII). 2. The cortical topography of visual and vestibular inputs was first examined. Visual units and ves

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Chalisova, N. I., and A. E. Korovin. "PROTECTIVE EFFECT OF AMINO ACIDS IN THE ORGANOTYPIC CULTURE OF THE ECTODERMAL GENESIS TISSUES AT THE CYCLOPHOSPHANE PRESENCE." Bulletin of the Russian Military Medical Academy 19, no. 4 (2017): 47–52. http://dx.doi.org/10.17816/brmma12431.

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The effect of the 20 coded amino acids was investigated on the development of the processes of the proliferation in the organotypic tissue culture of rat skin and brain cortex. Some amino acids at 0.05 ng/ml concentration stimulated the cellular proliferation in the growth zone of explants. The other inhibited it. The combination of the stimulating and inhibiting amino acids - Leucine with Proline or Tyrosine-, lead to the proliferation stimulation by 24-32%. The mustard-like agent cyclophosphane at 1 mg/ml concentration inhibited the cellular proliferation. However, the delay of this inhibiti

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Zhao, Yangbing, David Boczkowski, Smita K. Nair, and Eli Gilboa. "Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity." Blood 102, no. 12 (2003): 4137–42. http://dx.doi.org/10.1182/blood-2003-06-1867.

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Abstract Induction of potent and sustained antiviral or antitumor immunity is dependent on the efficient activation of CD8+ and CD4+ T cells. While dendritic cells constitute a powerful platform for stimulating cellular immunity, presentation of endogenous antigens by dendritic cells transfected with nucleic acid-encoded antigens favors the stimulation of CD8+ T cells over that of CD4+ T cells. A short incubation of mRNA-transfected dendritic cells with antisense oligonucleotides directed against the invariant chain enhances the presentation of mRNA-encoded class II epitopes and activation of

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Zhang, Jianwei, Wenjin Zhu, Jingyi Liang, et al. "In Situ Synthesis of Gold Nanoparticles from Chitin Nanogels and Their Drug Release Response to Stimulation." Polymers 16, no. 3 (2024): 390. http://dx.doi.org/10.3390/polym16030390.

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In this study, gold nanoparticles (AuNPs) were synthesized in situ using chitin nanogels (CNGs) as templates to prepare composites (CNGs@AuNPs) with good photothermal properties, wherein their drug release properties in response to stimulation by near-infrared (NIR) light were investigated. AuNPs with particle sizes ranging from 2.5 nm to 90 nm were prepared by varying the reaction temperature and chloroauric acid concentration. The photothermal effect of different materials was probed by near-infrared light. Under 1 mg/mL of chloroauric acid at 120 °C, the prepared CNGs@AuNPs could increase t

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DESSAUGE, Frédéric, Cindy SCHLEDER, Marie-Héléne PERRUCHOT, and Karl ROUGER. "Développement des modèles de culture cellulaire de muscle en 3D : de nouvelles opportunités pour les productions animales." INRAE Productions Animales 36, no. 2 (2023). http://dx.doi.org/10.20870/productions-animales.2023.36.2.7626.

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Le muscle squelettique est organisé en faisceau de fibres musculaires de différentes tailles et parcouru par des réseaux vasculaires et nerveux. Les cellules satellites sont des cellules souches logées le long des fibres musculaires et sont à la base des progéniteurs myogéniques (myoblastes). Les cellules satellites peuvent être aisément extraites du muscle et cultivées. Les modèles typiques de culture en deux dimensions (2D) de cellules dérivées du muscle squelettique ne peuvent pas recréer complètement l'organisation et la fonction des tissus musculaires vivants, ce qui limite leurs utilités

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Mellal, Yasmine, and Yasmine Lounici. "Pre- and Post-transplantation immunological tests." Batna Journal of Medical Sciences (BJMS), June 30, 2017, 77–82. http://dx.doi.org/10.48087/bjmstfa.2017.4116.

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Le système immunitaire a pour rôle essentiel de reconnaître le soi et de le tolérer et de reconnaître le non soi et de l’éliminer. Ce dernier point est à l’origine des rejets de greffes entre individus génétiquement différents. Dans la transplantation rénale, la recon-naissance des alloantigènes par le système immunitaire du receveur est responsable d’une réaction immune dirigée contre le greffon ; cette réponse est médiée soit par des mécanismes faisant intervenir les lymphocytes T (rejet cellulaire) et/ou les lymphocytes B (rejet humoral). Les alloantigènes à l’origine de cette stimulation i

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"Effect of P2-purinergic stimulation on single calcium channel activity F. Scamps, N. Nilius, J. Alvarez, G. Vassort. Laboratoire de Physiologie Cellulaire Cardiaque, INSERM U-241, 91405 Orsay, France." Journal of Molecular and Cellular Cardiology 24 (November 1992): 43. http://dx.doi.org/10.1016/0022-2828(92)93316-c.

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"Effect of P2-purinergic stimulation on single calcium channel activity F. Scamps, B. Nilius, J. Alvarez, G. Vassort. Laboratoire de Physiologie Cellulaire Cardiaque, INSERM U-241, 91405 Orsay, France." Journal of Molecular and Cellular Cardiology 24 (July 1992): 36. http://dx.doi.org/10.1016/0022-2828(92)93429-n.

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"P2-purinergic stimulation increases the Ca current in single frog cardiac cells G. Vassort, J. Alvarez, K. Mongo, Scamps F. Physiologie Cellulaire Cardiaque INSERM U-241, Universit� 91405 Orsay France." Journal of Molecular and Cellular Cardiology 21 (April 1989): S19. http://dx.doi.org/10.1016/0022-2828(89)91558-7.

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