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Rozprawy doktorskie na temat „Structural studies”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Naseer, Abeer. "Structural studies of higher order DNA structures." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515807.

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2

Bennett, J. E. "Structural and compositional studies of novel ribbon structures." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596574.

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This thesis documents the results of a structural and compositional study of selected mixed metal oxides possessing novel structures based upon 'ribbons' of corner sharing metal-oxygen octahedra. The techniques employed to characterise the specimens of interest have included Powder X-ray Diffraction (PXRD). High Resolution Transmission Electron Microscopy (HRTEM) and Energy Dispersive X-ray Spectroscopy (EDS). Compositional analysis of specimens containing strontium, lanthanum and titanium has been achieved to a high degree of accuracy using EDS analysis in the electron microscope. A mathemati

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3

Moran, Stephen John. "Structural Studies of Translation." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491502.

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Cellular translation is one of the fundamental processes that make life possible. It is the point at which stored information, coded by the nucleic acid, is read and converted into three-dimensional functional proteins. By linking together the correct sequence of amino acids, spontaneous order is created. It is truly a remarkable process. The plechanism by which this is achieved can be understood in physical terms, by the structure of the molecular machinery involved. These structures are dynamic and elegant and we can observe them in action. Through the application of the techniques of struct

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4

Ang, S. G. "Structural studies on peptides." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233709.

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The work presented in this thesis is primarily concerned with solving structural problems in peptides using a combination of classical chemical methods, mass spectrometry and nuclear magnetic resonance spectroscopy (NMR). Chapter One gives brief descriptions of the applications of fast atom bombardment mass spectrometry (FABMS) and NMR to the solution of structural problems in peptides. Chapter Two of this thesis describes the elucidation of the structure of vancomycin-type antibiotic, OA-7653, isolated from <i>Streptomyces hygroscopicus</i> subsp. <i>hiwasaensis</i> subsp. nov. Nishida. Chapt

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5

Spraggon, Glen. "Structural studies on proteins." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297295.

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6

Cockburn, Joseph John Berry. "Structural studies on bacteriophages." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442832.

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7

Diprose, Jonathan Marlborough. "Structural studies on orbiviruses." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365819.

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8

Wang, Wei. "Structural studies on chitosan." Thesis, Nottingham Trent University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389687.

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9

Wilkinson, Kay W. "Structural studies on metalloenzymes." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364295.

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10

Warburton, J. D. "Structural studies on carotenoproteins." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377126.

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11

Al-Saleh, S. S. H. "Structural studies on rhodopsins." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381264.

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12

Chapman, Allan Douglas Michael. "Structural studies of dehydrogenases." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310587.

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13

Weixlbaumer, Albert. "Structural studies on translation." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611985.

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14

Lee, Joo Hee. "Structural studies of glasses." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627292.

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15

Booth, Ewan D. "Structural studies in DNA." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/15191.

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Base pair mismatches may be formed during replication or genetic recombination. Not all mismatched base pairs are repaired with the same efficiency, in particular the A.G. mismatch is consistently under repaired. Why the A.G. mismatch is poorly repaired is not clear, although previous work has suggested the mismatch is conformationally flexible. In the present study the A.G. mismatch in the sequence dCGCAAATTGGCG was examined by X-ray crystallography and pH dependant UV melting studies. Crystals were grown at pH 6.6. The base pair has an A (<i>anti</i>).G(<i>syn</i>) conformation. From the pH

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16

Elbrghathi, Abdelhamid. "Structural studies on dehydrogenases." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7406/.

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The amino acid dehydrogenase superfamily has good potential for biotechnological use for example, either as enzymes for the production of non-natural amino acids, or for use as biosensors. Despite many years work on this family, there is still a gap understanding aspects of both substrate and cofactor binding and reaction mechanism. The crystal structures of M. smegmatis Glutamate dehydrogenase (GluDH) have been determined in two crystal forms, one of a ternary complex (GluDH/NADP+/2oxoglutarate) at 1.64A, and one of a binary complex (GluDH/NADPH) at 1.78A. The binary complex structures of C.

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17

Jamaluddin, Haryati. "Structural studies on glycosyltransferases." Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441452.

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18

de, Morais Cabral João Henrique Resende de Oliveira. "Structural studies on two lipocalins." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/28657.

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The number of proteins being included in the lipocalin structural family has been steadily increasing since the solution of the structures of beta-lactoglobulin and retinol-binding protein. The family now comprises some 21 proteins and these come from many different sources and display a variety of characteristics. The work described here focused on two of those proteins, beta-lactoglobulin (Blg) and apolipoprotein D (apo D). The structure of bovine beta-lactoglobulin from the trigonal crystals grown at pH 7.8, space group P3<SUB>2</SUB>21, presents several aspects that are in disagreement wit

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19

Parrish, Jonathan C. "Structural studies of cytochrome c." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq24760.pdf.

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20

Larsson, Anna. "Structural Studies of Three Glycosidases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6339.

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21

Pearce, Clive Michael. "Structural studies on natural products." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259614.

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22

Verrall, Diane Jane. "Structural studies of chalcogenide glasses." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333353.

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23

Gladden, L. F. "Structural studies of inorganic glasses." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233932.

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The present work has been concerned with a study of the structure of germanium and silicon dichalcogenide glasses. Initially, the aim of this research was to obtain direct structural evidence of reversible photostructural changes in bulk germanium chalcogenide glasses. However, having confirmed the existence of such changes using EXAFS and neutron scattering techniques, it became obvious that a more comprehensive understanding of the as-quenched, annealed glass structure is required before a valid interpretation of the data can be made; in particular, the extent of medium-range order in these

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24

Rohou, Alexis Lawrence. "Structural studies of Î±-latrotoxin." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441979.

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25

Da, Fonseca Paula Cristina Alves. "Structural studies of cyanobacterial PSII." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249460.

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26

Long, Alexandra. "Structural studies on penicillin biosynthesis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393574.

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27

Tate, John Graham. "Structural studies on bovine enterovirus." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318546.

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28

Grimes, Jonathan Mark. "Structural studies on Bluetongue virus." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260746.

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29

Zaccai, Nathan R. "Structural studies on immune receptors." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393447.

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30

Bartlam, Mark Gerrard. "Structural studies of amyloid proteins." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342536.

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31

Ren, Jingshan. "Structural studies on biological macromolecules." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334959.

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32

Anthis, Nicholas J. "Structural studies of integrin activation." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:caf0f76f-b05a-4b72-8394-5f24de3fd5df.

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Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that link the extracellular matrix to the actin cytoskeleton. Uniquely, these adhesion receptors mediate inside-out signal transduction, whereby extracellular adhesion is activated from within the cell by talin, a large cytoskeletal protein that binds to the cytoplasmic tail of the β integrin subunit via its PTB-like F3 domain. Features of the interface between talin1 and small β3 fragments only have been described previously. Through NMR studies of full-length integrin β tails, we have found that β

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33

Mullan, C. L. "Structural studies of Ionic Liquids." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527876.

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34

Brennan, Damian Frederick. "Structural studies of MAPK signalling." Thesis, Institute of Cancer Research (University Of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511162.

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35

Malkova, Barbora. "Structural studies of cytoplasmic dynein." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540206.

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36

Ball, L. J. "Structural studies of transcriptional regulators." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596318.

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Both of the proteins studied in this work are involved in the control of gene expression at the transcriptional level. The first project described in this thesis involves the elucidation of the precise zinc co-ordination in the native zinc form of the PPR1 DNA-binding domain. PPR1 is a transcriptional activator found in the yeast, <I>Saccharomyces cerevisiae</I>, which specifically binds DNA in order to activate a series of genes involved in pyrimidine biosynthesis. The zinc-binding domain of PPR1 is highly conserved across a large number of yeast transcriptional activators and is important fo

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37

Leath, Kirstin J. "Structural Studies of Complement Regulators." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526076.

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38

O'Connell, M. J. "Structural studies in alicyclic systems." Thesis, University of Canterbury. Chemistry, 1987. http://hdl.handle.net/10092/7252.

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The crystal structures of exo- (22) and endo- (23) adducts of tetracyclone and cyclopentadiene have been determined and the relative orientations of the four phenyl rings shown to be similar in the two structures. The reactions between hemicyclone and a number of substituted benzoquinones gave a series of Diels-Alder adducts. Photolysis of the adducts gave derivatives of (21) and/or (29) other reactions of the parent compound with various reagents were studied. The X-ray crystal structures of oxetane (29) and cyanohydrin (55) were determined. The reactions of the diene (37) with twenty-two d

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39

Shum, Kwok-yan Daisy, and 岑國欣. "Structural studies on urinary glycosaminoglycans." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31230933.

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40

Hunt, James. "Structural studies of immunoglobulin E." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/structural-studies-of-immunoglobulin-e(251aec27-5e3a-4ce5-9fbe-9493d158129d).html.

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41

Smith, Linda J. "Structural studies of adsorbed proteins." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320864.

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42

Briggs, David Christopher. "Structural studies of bacterial toxins." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414899.

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43

Walas, Fabien Patrick. "Structural studies of multidrug transporters." Thesis, Birkbeck (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425356.

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44

Picken, Nichola Caryl. "Structural studies of porphobilinogen deaminase." Thesis, Birkbeck (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314290.

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45

Hodgson, Susan Marie. "Structural studies of lithium compounds." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244863.

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46

Yewdall, S. J. "Structural studies of Beta-lactoglobulin." Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233792.

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47

Turnbull, Andrew Paul. "Structural studies on leucine dehydrogenase." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245693.

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48

Fawcett, Ian D. "Structural studies of disordered molybdates." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320188.

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49

Moroz, Olga. "Structural studies on human S100A12." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403963.

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50

Done, Sarah Helen. "Structural studies of penicillin acylase." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481793.

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