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Rozprawy doktorskie na temat „SUMO Protease”

Autor: Grafiati
Data publikacji: 6 września 2023
Data aktualizacji: 31 lipca 2025

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Sprawdź 26 najlepszych rozpraw doktorskich naukowych na temat „SUMO Protease”.

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1

Elmore, Zachary Cole. "SUMO-Dependent Substrate Targeting of the SUMO Protease Ulp1." W&M ScholarWorks, 2011. https://scholarworks.wm.edu/etd/1539626905.

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Hattersley, Neil. "Characterisation of the SUMO protease SenP6." Thesis, University of Dundee, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521677.

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Guillotte, Mark. "Identifying SUMO Protease Targets and Investigating E3 Ligase Interactions." W&M ScholarWorks, 2014. https://scholarworks.wm.edu/etd/1539626956.

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CASTELLUCCI, FEDERICA. "THE ROLE OF THE S. CEREVISIAE SUMO PROTEASE ULP2 IN DNA REPLICATION AND GENOME INTEGRITY." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/155578.

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Sumoylation has emerged as an important player in several biological processes involved in the maintenance of genome stability. A number of proteins implicated in DNA metabolism-associated processes, such as DNA replication, repair and chromosome segregation, were shown to sumoylated. Moreover, alterations in protein sumoylation and desumoylation, caused by deregulation of enzymes involved in the SUMO pathway, were associated with cancer development. Work done previously in our laboratory and by other groups suggested an important role for sumoylation in promoting DNA damage tolerance. However
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5

Era, Saho. "The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment." Kyoto University, 2013. http://hdl.handle.net/2433/174794.

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Eckhoff, Julia [Verfasser], Jürgen [Gutachter] Dohmen, and Kay [Gutachter] Hofmann. "Mechanistic and structural characterization of the SUMO-specific protease Ulp2 / Julia Eckhoff ; Gutachter: Jürgen Dohmen, Kay Hofmann." Köln : Universitäts- und Stadtbibliothek Köln, 2016. http://d-nb.info/1115330659/34.

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7

Maroui, Mohamed Ali. "Rôle et devenir de PML lors de l’infection par l’EMCV." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T008/document.

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PML et les corps nucléaires (CN) sont impliqués dans la défense antivirale. En effet, notre équipe a montré que la surexpression de PMLIII confère la résistance au virus de la stomatite vésiculaire, au virus de l'influenza, au virus foamy mais pas au virus de l’encéphalomyocardite (EMCV). J’ai montré dans mon travail de thèse que l’EMCV contrecarre le pouvoir antiviral de PMLIII en induisant sa dégradation par un processus dépendant du protéasome et de SUMO. Cependant, les cellules de souris invalidées pour PML sont plus sensibles à l’infection par l’EMCV que les cellules issues de souris pare
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8

Rouvière, Jérôme. "Etude du rôle de la sumoylation dans le métabolisme des ribonucléoparticules d'ARN messagers (mRNPs)." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS069.

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Au sein des cellules, les ARNms sont liés par de nombreuses protéines, générant ainsi des particules appelées mRNPs (Ribonucléoparticules de messagers). Leur formation est cotranscriptionnelle, et leur composition va réguler l’ensemble des étapes du métabolisme des ARNms : stabilité, maturation, export, localisation et traduction. Au vu de l’importance de ces mécanismes dans la physiologie cellulaire, le contenu protéique des mRNPs est finement régulé dans le temps et l’espace et fait l’objet de nombreux remodelages. Ces changements de composition dépendent notamment des hélicases, ainsi que d
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9

Ulbricht, David, Jan Pippel, Stephan Schultz, René Meier, Norbert Sträter та John T. Heiker. "A unique serpin P1′ glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin)". Portland Press, 2015. https://ul.qucosa.de/id/qucosa%3A33439.

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SerpinA12 (vaspin) is thought to be mainly expressed in adipose tissue and has multiple beneficial effects on metabolic, inflammatory and atherogenic processes related to obesity. KLK7 (kallikrein 7) is the only known protease target of vaspin to date and is inhibited with a moderate inhibition rate. In the crystal structure, the cleavage site (P1-P1′) of the vaspin reactive centre loop is fairly rigid compared with the flexible residues before P2, possibly supported by an ionic interaction of P1′ glutamate (Glu379) with an arginine residue (Arg302) of the β-sheet C. A P1′ glutamate seems high
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10

Alegre, Kamela Olivya. "Structural and Fumctional Analysis of the SUMO Proteases SENP6 and SENP7." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/121596.

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Intercambiar la especifidad de las isoformas de SUMO1 y SUMO2/3 para SENP6/SENP7 SENP6 y SENP7 son los miembros más divergentes de la familia de proteasas SENP y los únicos miembros que llevan cuatro inserciónes o “loops” localizadas en su dominio catalítico. Al sobreponer el dominio catalítico de SENP7 sobre el complejo SENP2-SUMO podemos ver una posible interfaz entre el Loop1 de SENP7 y SUMO. También identificamos diferentes residuos de SUMO1 y SUMO2 que podrían formar parte de la interfaz. Diseñamos una serie de mutantes de SUMO1 y SUMO2 donde se intercambian entre ellos los residuos q
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11

Schergaut, Marion Petra. "Struktur-, Funktionsanalyse und Ubiquitinierung des Ubiquitin-ähnlichen Modifizierers SUMO1." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973065117.

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12

Yates, Gary. "Identification of a new class of SUMO proteases in plants, and investigation into the role of SUMOylation in pathogen perception." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12494/.

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Plants, as primary produces of energy and the main source of food for many organisms, are both ecologically and economically important to sustaining life. Understanding the molecular mechanisms by which plants respond to stress is key to optimizing food production and maintaining biodiversity in an increasingly uniform global ecosystem. Arabidopsis thaliana is the major model plant species in which primary research provides insights into the workings of more important plant species. The research presented here advances our understanding of the role of SUMOylation and deSUMOylation in plants. T
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13

Basu, Shrivastava Meenakshi. "Régulation de la stabilité de NFATc3 par SUMO et les E3 ubiquitine-ligases Trim39 et Trim17." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT043.

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Les facteurs de transcription NFAT (facteur nucléaire des cellules T activées) jouent un rôle physiologique important dans le développement et le fonctionnement de nombreux organes, notamment dans le système immunitaire et le système nerveux. Par conséquent, leur dérégulation a été impliquée dans diverses maladies humaines telles que le cancer, les maladies neurodégénératives et les maladies auto-immunes. La régulation de l'activité de NFAT par translocation nucléo-cytoplasmique a été largement étudiée. En revanche, la régulation du niveau protéique de NFAT par le système ubiquitine-protéasome
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14

Paolinelli, Francesca. "La serin proteasi HtrA1: studio del suo potenziale ruolo di "biomarker" tissutale, urinario e plasmatico del cancro uroteliale vescicale umano e del suo possibile coinvolgimento nello sviluppo della malattia neoplastica." Doctoral thesis, Università Politecnica delle Marche, 2013. http://hdl.handle.net/11566/242683.

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Il carcinoma della vescica è uno dei tumori di più frequente riscontro da parte dell’urologo, rappresentando la seconda principale causa di decesso fra tutte le neoplasie del tratto genitourinario. Più del 90% delle neoplasie maligne della vescica è rappresentato dai carcinomi delle cellule uroteliali. La scarsità di procedure non invasive attendibili per la diagnosi precoce, cui va aggiunta la complessa eterogeneità biologica che questo tumore riscontra nella pratica clinica, sono alla base dei decennali tentativi della comunità scientifica nell’individuazione di biomarcatori tumorali,
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15

Bailey, Mark. "An investigation into the role of SUMO proteases OVERLY TOLERANT to SALT1 and -2 in salicylic acid mediated defense signalling in Arabidopsis thaliana : toward understanding the role of SUMOylation in SA signalling." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/67030/.

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Enzymatic, covalent attachment of the Small Ubiquitin-like Modifier (SUMO) protein to a substrate protein, SUMOylation, is a stress inducible post-translational modification conserved throughout eukaryotes. SUMO conjugation to proteins alters protein interactions, regulating signalling pathways in the cell, and modulating response. SUMO proteases process SUMO into its mature form as a prerequisite to conjugation, in addition to providing reversibility to the SUMOylation pathway by cleaving SUMO from substrate proteins. Salicylic acid (SA) is a key hormone in propagating defense activation and
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16

Fadda, Elisa. "A new SOS-DFPT approximation for NMR shielding calculations : the Loc.3 correction applied to the catalytic mechanism of Serine Proteases." Thèse, [Montréal] : Université de Montréal, 2003. http://wwwlib.umi.com/cr/umontreal/fullcit?pNQ92745.

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Thèse (Ph.D.) -- Université de Montréal, 2004.<br>"Thése [sic] présentée à la Faculté des études supérieures en vue de l'obtention du grade de Philosophiae Doctor (Ph.D.) en chimie" Version électronique également disponible sur Internet.
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17

Chakraborty, Suryadeep. "Investigation of Psychrophilic SUMO Proteases: Towards a More Efficient SUMO Protease at Lower Temperature." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5897.

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Covalent attachment of the fusion protein, Small Ubiquitin-like modifier (SUMO), to recalcitrant target proteins (especially transmembrane proteins) make purification of the target protein much easier by enhancing its recombinant overexpression, protecting from degradation and improving protein folding, solubility and stability. After purification of the SUMO-tagged protein, SUMO protease (Ulp1), which specifically cleaves the SUMO-tag, is required to regenerate the native target protein. However, the known SUMO protease enzyme from Saccharomyces cerevisiae i.e., S.ce. Ulp1 enzyme
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18

Lourenço, Tiago Jorge Moreira. "Functional characterization of potential SUMO protease targets in Arabidopsis thaliana." Master's thesis, 2017. http://hdl.handle.net/1822/54829.

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Dissertação de mestrado em Plant Molecular Biology, Biotechnology and Bioentrepreneurship<br>Unpredictable environmental changes have a negative impact on plant development. To respond to these abiotic and biotic stresses, plants adapted by improving intricate molecular mechanisms, including post-translational modifications (PTMs) that are responsible for modifying proteins and consequently modulating their activity. An important PTM is the fast and reversible attachment of the SUMO peptide, known as sumoylation. It is well reported that sumoylation controls several essential processes in
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19

Schwarz, Michael [Verfasser]. "Charakterisierung der SUMO-bindenden Protease Wss1 / vorgelegt von Michael Sven Schwarz." 2010. http://d-nb.info/1010948415/34.

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20

Chen, Song-Yuan, and 陳松遠. "Regulation of Histone deacetylase 3 and Sentrin/SUMO-Specific Protease 1 by miR-X." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/21848108013291444532.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>MicroRNAs are endogenous, single-strand RNA molecules that regulate gene expression. MicroRNAs have been identified in different species such as Drosophila, mouse and human. MicroRNA genes located within introns, exons or intergenic areas were transcribed by RNA polymerase II or RNA polymerase III. MicroRNAs are important gene regulators that control cell growth, cell proliferation, cell differentiation and cell death. Recent results have shown that microRNA mutation, amplification, deletion or epigenetic silencing was correlated with various human diseases
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21

Gebura, Myroslav. "Nanobodies as new tools for studying large cargo transport and lamina organization." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-002E-E42F-E.

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22

Uzunova, Kristina Marinova. "Proteolytic control of SUMO conjugates /." 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017062212&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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23

"Structural and functional analysis of SUMO specific proteases." Thesis, 2007. http://library.cuhk.edu.hk/record=b6074355.

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During the activation and transferring process, E1 and E2 form a thioester-linkage with SUMOs. By using an in vitro assay, it is demonstrated that SENP1 is able to cleave the thioester-linkage between SUMO-1/SUMO-3 and E1/E2. This finding suggests that SUMO proteases regulate the sumoylation pathway, not only during maturation and deconjugation, but also in the E1 activation and E2 conjugation processes.<br>Recently, reactive oxygen species have been demonstrated to influence the equilibrium of sumoylation-desumoylation. Here, by in vitro assay, it is shown that H2O2 induces formation of inter
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Santos, Miguel Ângelo Costa e. Silva dos. "Functional characterization of ULP2 SUMO proteases in Arabidopsis thaliana." Master's thesis, 2014. http://hdl.handle.net/1822/34556.

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Dissertação de mestrado em Molecular Genetics<br>In modern times it has become crucial to provide sustenance for a constantly growing world population, and crop improvement is a current major issue, especially considering the added effects of a changing climate and continuous soil impoverishment. In order to address environmental challenges, plants have developed different defense mechanisms, and studying the way that cells respond to these stresses is an increasingly significant area of research. Post-translational modifications (PTM) are major regulators at the molecular level, increasi
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Huang, Pei-Tzu, and 黃珮慈. "Study of the Proteasome 19S Rpt5 ATPase Activity Affected by SUMO Modification." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/94353590322226340786.

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碩士<br>國立臺灣大學<br>生化科技學系<br>102<br>The 26S proteasome is composed of 20S core particle (CP) capped with 19S regulatory particle (RP). Regulatory particle triple-A ATPase 5 (Rpt5) is one of the subunits of the 19S RP, which forms the base of 19S RP together with Rpt1, Rpt2, Rpt3, Rpt4 and Rpt6. The 19S base performs several functions, such as polyubiquitin chain recognition, substrate unfolding, gate opening and also translocation of target proteins into 20S CP. Our previous study has revealed that Rpt5 was modified by small ubiquitin-like modifier 2 (SUMO2) in COS7 cells, and modified by SUMO1 a
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26

Picard, Nathalie. "Régulation dynamique de l’activité du récepteur des estrogènes beta (ERβ) par la phosphorylation,l’ubiquitination et la sumoylation". Thèse, 2011. http://hdl.handle.net/1866/6272.

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Les estrogènes jouent un rôle primordial dans le développement et le fonctionnement des tissus reproducteurs par leurs interactions avec les récepteurs des estrogènes ERα et ERβ. Ces récepteurs nucléaires agissent comme facteurs de transcription et contrôlent l’expression des gènes de façon hormono-dépendante et indépendante grâce à leurs deux domaines d’activation (AF-1 et AF-2). Une dérégulation de leur activité transcriptionnelle est souvent à l’origine de pathologies telles que le cancer du sein, de l’endomètre et des ovaires. Alors que ERα est utilisé comme facteur pronostic pour l’utilis
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