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Rozprawy doktorskie na temat „Suppressive myeloid cells”

Autor: Grafiati

Data publikacji: 30 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Benner, Brooke Nicole. "Enhancing Immunotherapy for Cancer by Targeting Suppressive Myeloid cells." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1583766367545941.

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Ortiz, Myrna Lillian. "Immature Myeloid Cells Promote Tumor Formation Via Non-Suppressive Mechanism." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5089.

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ABSTRACT Although there is ample evidence linking chronic inflammation with cancer, the cellular mechanisms involved in early events leading to tumor development remain unclear. Myeloid cells are an intricate part of inflammation. They consist of mature cells represented by macrophages, dendritic cells and granulocytes and a population of Immature Myeloid Cells (IMC), which in healthy individuals are cells in transition to mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a re

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3

Collazo, Ruiz Michelle Marie. "The Role of Tumor Suppressors, SHIP and Rb, in Immune Suppressive Cells." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4016.

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Regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSC) have been extensively studied in the past 30-40 years. Their potent suppressive capacity shown in several pathological and clinical settings, such as cancer and transplantation, has made it evident that better understanding their development and function is critical. Specifically, Tregs play a pivotal role in preventing autoimmunity, graft-versus-host disease (GvHD), and organ graft rejection. We previously demonstrated that germline or induced SH2 domain-containing inositol 5-phosphatase (SHIP) deficiency in the host abr

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4

Zwing, Natalie [Verfasser], Falk [Akademischer Betreuer] Nimmerjahn, Falk [Gutachter] Nimmerjahn, and Gerhard [Gutachter] Krönke. "Spatial Distribution of Suppressive Myeloid Cells and Cytotoxic T Cells in Colorectal Cancer / Natalie Zwing ; Gutachter: Falk Nimmerjahn, Gerhard Krönke ; Betreuer: Falk Nimmerjahn." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/123423856X/34.

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5

Boyer, Thomas. "Impact des cellules myéloïdes immunosuppressives dans l’induction de cellules souches cancéreuses." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0221.

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Le micro-environnement tumoral est fortement influencé par les cellules myéloïdes, dont les macrophages, les neutrophiles et les monocytes sont des représentants majeurs. Les recherches des dernières décennies ont montré que presque toutes les tumeurs sont infiltrées par des cellules myéloïdes, rendant impossible l'existence de tumeurs "froides" en ce qui concerne ces cellules. De plus, les résultats de nombreuses études cliniques se focalisant sur le compartiment immunitaire myéloïde montrent clairement que ces cellules sont presque universellement associées avec un pronostique clinique négat

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6

Ricchetti, Giuseppe Antonio. "An examination of the suppression of IL-10 suppression of TNF in myeloid cells." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427864.

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7

Ko, Jennifer S. "Mechanism of Myeloid-Derived Suppressor Cell Accumulation in Cancer and Susceptibility to Reversal by Sunitinib." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1259869673.

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8

Cabbage, Sarah E. "Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5034.

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9

Corzo, Cesar Alexander. "Regulatory Mechanism of Myeloid Derived Suppressor Cell Activity." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3561.

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Myeloid-derived suppressor cells (MDSC) are a major component of the immune suppressive network that develops during cancer. MDSC down-regulate immune surveillance and antitumor immunity and facilitate tumor growth. The ability of MDSC to suppress T cell responses has been documented; however the mechanisms regulating this suppression remain to be understood. This work proposes a biological dichotomy of MDSC regulated by the tumor microenvironment. In peripheral lymphoid organs MDSC cause T-cell non-responsiveness that is antigen-specific. These MDSC have increased expression of NOX2, enabling

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10

TUMINO, NICOLA. "In HIV+ patients, Myeloid Derived Suppressor Cells induce T cell anergy by suppressing CD3ζ expression through ELF-1 inhibition". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/211078.

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The CD3ζ chain is indispensable for coupling antigen recognition to T cell response. During HIV infection, a down-modulation of CD3ζ was found on T cells, contributing to T cell anergy. It has been shown that circulating myeloid derived suppressor cells (MDSC) are elevated in HIV+ patients, and correlate with disease progression. In this work, we studied the correlation between MDSC frequency and T cell CD3ζ expression. Moreover, we investigated the mechanisms of CD3ζ decrease exploited by MDSC. CD3ζ expression and MDSC frequency were evaluated by flow cytometry on PBMC from 105 HIV+

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11

Alkhateeb, Tuqa. "Development, Expansion and Role of Myeloid-Derived Suppressor Cells in Post-Sepsis Immune Suppression." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3787.

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Myeloid-derived suppressor cells (MDSCs) numbers increase significantly in sepsis and are associated with high mortality rates. These myeloid cell precursors promote immunosuppression, especially in the late (post sepsis) stage. However, the mechanisms that underlie MDSC expansion and programming are not completely understood. To investigate these mechanisms, we used a cecal-ligation and puncture (CLP) mouse model of polymicrobial sepsis that progresses from an early/acute proinflammatory phase to a late/chronic immunosuppressive phase. Previous studies in our laboratory showed that microRNA (

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12

Pinton, Laura. "The crosstalk between activated T cells and Myeloid Derived Suppressor Cells: characterization of molecular mechanisms involved in immune suppression." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423699.

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One of the mechanisms used by cancer to evade the immune response is the expansion of myeloid-derived suppressor cells (MDSCs), a population of immature myeloid cells able to inhibit immune responses in cancer patients and experimental animals with neoplasia. The role of MDSCs in promoting tumor growth and metastasis has gained importance over the years, highlighting the need to find specific target of intervention that could be used in the treatment of cancer patients. The aim of the present work was to analyze the signaling pathways active in MDSCs, using an in vitro model of MDSC gene

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13

Sandwick, Sarah [Verfasser], and Manfred [Akademischer Betreuer] Lutz. "Suppression of Experimental Autoimmune-Encephalomyelitis by Myeloid-Derived Suppressor Cells / Sarah Sandwick. Betreuer: Manfred Lutz." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1026211026/34.

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14

Horikawa, Naoki. "Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225478.

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15

Giunti, Giulia. "Immune suppression in multiple myeloma : strategies to overcome NK cell inhibition." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/immune-suppression-in-multiple-myeloma(9dc25961-3ae3-48e5-8adc-847cc6eaa0e1).html.

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Multiple myeloma (MM) is an essentially incurable malignancy associated with profound cellular and soluble immune deficiencies. Despite recent progresses in the treatment of MM, the prognosis remains frequently poor due to the difficulty in targeting MM progenitor cells, which are responsible for disease relapse. Immunotherapy, and in particular the employment of Natural Killer (NK) cells, offers the potential to target and eliminate MM cells within the bone marrow stromal sanctuaries, where they appear to be better protected against conventional therapeutic interventions. However, these strat

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16

Uhel, Fabrice. "Cellules suppressives d'origine myéloïde au cours du sepsis." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B002/document.

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Le sepsis est à l’origine d’une dysfonction immunitaire prolongée responsable d’infections nosocomiales et d’une mortalité tardive élevée. Sa physiologie complexe demeure mal connue et il n’existe aucun traitement spécifique en dehors de l’antibiothérapie et des thérapeutiques de suppléance d’organes. Nous nous sommes intéressés au rôle des cellules myéloïdes dans cette dysfonction immunitaire. Nous avons pu montrer qu’il existe chez les patients atteints de sepsis une augmentation du nombre de cellules suppressives d’origine myéloïde monocytaires (M-MDSC) CD14+HLA-DRlow/- et granulocytaires (

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17

Chretien, Marie-Lorraine. "Rôle de Tif1gamma dans les différenciations granulo-monocytaire et macrophagique." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS060/document.

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La LMMC est une pathologie clonale de la cellule souche hématopoïétique dont les caractéristiques la classent parmi les syndromes myélodysplasiques/myéloprolifératifs (SMD/SMP). L’invalidation conditionnelle de Tif1γ au niveau hématopoïétique chez la Souris (Tif1γΔ/Δ) est responsable du développement d’un SMD/SMP mimant la LMMC humaine lorsque la souris atteint l’âge de 6 mois, faisant de Tif1γ un gène suppresseur de tumeur. Par ailleurs, malgré une monocytose, la population macrophagique péritonéale de ces souris est diminuée.Les objectifs de mon travail étaient de caractériser chez les souri

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18

Ladoire, Sylvain. "Aspects fonctionnels et pronostiques des cellules myéloïdes suppressives et de Foxp3 dans le cancer." Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00692375.

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L'échappement des cellules tumorales au processus d'immunosurveillance semble être une condition nécessaire au développement tumoral dans les modèles précliniques, comme chez l'homme. Les mécanismes par lesquels la tumeur parvient à médier une immunosubvertion sont multiples et font intervenir la plupart des cellules du système immunitaire, au sein desquelles, les cellules immunorégulatrices telles les cellules myéloides suppressives (MDSCs) ou les lymphocytes T régulateurs (Tregs, exprimant le facteur de transcription Foxp3), semblent jouer un rôle prépondérant. Les résultats présentés dans c

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19

Gerard, Claire. "Développement d’une stratégie thérapeutique immunosuppressive dérivée de cellules myéloïdes dans la maladie du greffon contre l’hôte." Thesis, Bourgogne Franche-Comté, 2020. https://nuxeo.u-bourgogne.fr/nuxeo/site/esupversions/a02d57d7-6368-477d-8e8d-0badac13bda0.

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Résumé :Notre équipe a développé une thérapie cellulaire originale dérivant de la lignée monocytaire. Cette sous-population de cellules humaines suppressives d’origine myéloide, appelée Human Monocyte-derived Suppressor Cells (HuMoSC, cellules CD33+), est capable d’inhiber la prolifération des lymphocytes T effecteurs et d’induire des CD4 et CD8 Treg. De plus, les HuMoSC préviennent l’apparition de la maladie du greffon contre l’hôte (GvHD).Dans un premier temps, nous avons montré qu’un environnement inflammatoire ou la présence d’immunosuppresseurs ne diminuaient pas la capacité des HuMoSC à

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20

Sandwick, Sarah. "Suppression of Experimental Autoimmune-Encephalomyelitis by Myeloid-Derived Suppressor Cells." Doctoral thesis, 2012. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-72690.

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Autoimmune diseases, unwanted overshooting immune responses against self antigens, are due to an imbalance in immunity and tolerance. Although negatively impacting cancer prognosis, myeloid derived suppressor cells (MDSC), with their potent suppressive capabilities, might be applicable in a more beneficial light when applied in to autoimmunity. As previous shown MDSC have protective roles in Experimental Autoimmune Encephalomyelitis (EAE) (Zhu et al., 2007), the established inducible mouse model for the autoimmune disease multiple sclerosis (MS). This decrease in disease severity indicates in

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21

Steding, Catherine E. "The Role of Interleukin-12 on Modulating Myeloid-Derived Suppressor Cells." Thesis, 2011. http://hdl.handle.net/1805/2491.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>More than 200,000 American women are diagnosed with breast cancer each year. Although therapies effective in treating metastatic breast cancer currently exist, each year approximately 40,000 women die from this disease. Current evidence indicates that anti-cancer immune responses can be induced by vaccination in situ to the growth of metastasis and protect patients from the tumor recurrence. However, induction of anticancer immune responses may be limited in their efficacy due to immune suppression mechanisms induced by the developi

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22

Zhao, Wei. "Decreased JMJD3 expression in mesenchymal stem cells contributes to longterm suppression of osteoblast differentiation in multiple myeloma." Diss., 2018. https://doi.org/10.7912/C2107D.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Multiple myeloma (MM) is the most frequent cancer to involve the skeleton, with over 80% of myeloma patients developing lytic bone disease (MMBD). Importantly, MM-associated bone lesions rarely heal even when patients are in complete remission. Bone marrow stromal cells (BMSCs) isolated from MM patients have a distinct genetic profile and an impaired osteoblast (OB) differentiation capacity when compared to BMSCs from healthy donors. Utilizing an in vivo model of MMBD and patient samples, we showed that BMSCs from tumor-bearing

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