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Rozprawy doktorskie na temat „Suppressor cells Identification”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 19 lutego 2022

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1

Francis, Christopher Ryan. "Identification and analysis of prohibitin in B16 Mouse Melanoma Cells." [Huntington, WV : Marshall University Libraries], 2008. http://www.marshall.edu/etd/descript.asp?ref=868.

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Thesis (M.S.)--Marshall University, 2008.<br>Title from document title page. Includes abstract. Document formatted into pages: contains vi, 69 p. : ill. Includes bibliographical references (p. 59-65).

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2

Sherger, Matthew George. "Identification of Myeloid Derived Suppressor Cells in Tumor Bearing Dogs." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337617975.

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Zhang, Liyi, and 張麗儀. "Identification and characterization of tumor suppressor gene and cancer stemness gene in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/208563.

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Esophageal squamous cell carcinoma (ESCC), the major histological subtype of esophageal cancer, is one of the most common malignancies with poor prognosis in the world. Despite continued development of diagnosis and treatment, ESCC remains the sixth leading cause of cancer death worldwide. Current treatment regimens in ESCC are often characterized by ineffectiveness and poor selectivity. Therapeutic methods directed at cancer-associated genes or cancer stem cells (CSCs) may be effective approaches to cure this deadly cancer. Therefore, this study aims to identify specific ESCC-related genes an

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Ring, Giselle Natasha. "Identification and characterization of TMEM 85, a novel suppressor of bax-mediated cell death in yeast." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112352.

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The ability to evade apoptosis is an acquired characteristic associated with many normal and pathophysiological processes. TMEM 85 represents a novel transmembrane domain containing human protein isolated in our previous screen for Bax suppressors, but whose function is currently unknown. Using viability and growth assays, we confirmed that TMEM 85 is anti-apoptotic. Four unique human cDNA sequences containing regions distinct from and of perfect identity to our cDNA were present in the database. Analysis of TMEM 85 suggests that it consists of five exons, alternatively spliced to produce at l

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Guo, Tianhuan, and 郭天欢. "Identification of tumor suppressor genes in the commonly deleted region of chromosome 6q in NK-cell malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43785761.

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Guo, Tianhuan. "Identification of tumor suppressor genes in the commonly deleted region of chromosome 6q in NK-cell malignancies." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43785761.

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Dahmani, Rajae. "Identification d’une nouvelle isoforme du gène suppresseur de tumeur LKB1 ayant des propriétés oncogéniques." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T053/document.

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LKB1 est un gène suppresseur de tumeur qui code une kinase « maitre » dont l’activité contrôle la polarité et la prolifération cellulaire en les coordonnant avec l’état métabolique de la cellule. Ce travail a abouti à l’identification d’une nouvelle isoforme LKB1 appelée ∆N-LKB1 qui est générée par transcription alternative et initiation interne de la traduction de l'ARNm LKB1. La protéine ∆N-LKB1 est délétée de sa partie N-terminale incluant une partie de son domaine kinase. Bien que la protéine N-LKB1 soit catalytiquement inactive, elle potentialise l'effet activateur de la protéine LKB1 su

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8

Wong, Chun-lam, and 黃俊霖. "Identification and functional analysis of candidate tumor suppressor genes in chromosome 9 in esophageal squamous cell carcinoma (ESCC)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45204214.

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Hamze, Zeinab. "Études fonctionnelles du gène suppresseur de tumeurs MEN1 : « Identification des bases moléculaires de la spécificité endocrine de sa fonction suppresseur de tumeurs »." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10094.

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La Néoplasie Endocrinienne Multiple de type1 (NEM1) est une maladie à transmission autosomique dominante liée à l'inactivation du gène MEN1 codant pour la protéine ménine. Bien que ménine soit exprimée dans tous les tissus testés de l'organisme, elle n'a un effet oncosuppresseur que dans les cellules endocrines. L'hypothèse de mon travail est que ménine interagit avec des fonctions endocrines spécifiques. J'ai ciblé mes études sur une lignée de cellules β pancréatiques INS-1 dans laquelle j'ai étudié la réponse cellulaire au glucose et la régulation du facteur de transcription MAFA en fonction

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10

Nothdurft, Silke [Verfasser], and Martin [Akademischer Betreuer] Schuler. "Identification and characterization of aryl hydrocarbon receptor (AHR) as a suppressor of non-small-cell lung cancer metastasis / Silke Nothdurft ; Betreuer: Martin Schuler." Duisburg, 2021. http://d-nb.info/1240145101/34.

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11

Rowntree, Clare Judith. "Identification and characterisation of candidate tumour suppressor genes from chromosome 13q14.3, an area of frequent deletion in patients with B-cell chronic lymphocytic leukaemia." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390595.

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12

Doumont, Gilles. "Identification et caractérisation de nouveaux médiateurs de l'activité biologique de la protéine suppresseur de tumeur p53." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211022.

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Le suppresseur de tumeur p53 permet à la cellule de se défendre contre différentes formes de stress. Il joue un rôle de barrière s'opposant à la tumorigenèse: en effet la perte de p53 chez la souris prédispose grandement ces animaux à développer des tumeurs; de même le locus p53 est inactivé dans près de 50% des tumeurs humaines.<p>p53 constitue un facteur de transcription qui se lie à des séquences particulières de l'ADN et active l'expression des gènes adjacents. L'expression orchestrée de ces gènes conduit, directement ou indirectement et suivant le contexte cellulaire, soit à la mort de la

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13

Chen, Chian-Feng, and 陳建鋒. "Identification of Homozygous Deletion at 13q12.11 in SK-Hep-1 cells and Positional Cloning of Candidate Tumor Suppressor Gene for Hepatocellular Carcinoma." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/83148368309467673174.

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博士<br>國防醫學院<br>生命科學研究所<br>93<br>Abstract Liver cancer is the sixth most common cancer worldwide especially in tropical Africa and south-east Asia. In Taiwan, hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality in the past decades. For revealing therapeutic and diagnostic targets in HCC treatment, we decided to search and clone cancer genes involved in HCC tumorgenesis. In our laboratory, we previously reported genome-wide loss of heterozygosity (LOH) analysis in HCC genome and revealed 33 minimal deletion regions (MDRs). To further identify putative tumor suppre

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Lin, Shi-Xian, and 林師賢. "Identification of proteins involved in the suppressed cell proliferation by knockdown of Ribose-5-phosphate Isomerase A in cancer cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/83569510961855346267.

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碩士<br>國立清華大學<br>生物科技研究所<br>104<br>Lung cancer and liver cancer are the first and the second leading cause of cancer related death from cancers worldwide. Our previous studies indicate the expression of ribose 5-phosphate isomerase A (RPIA) is higher in lung tumor and liver tumor biopsy than normal adjacent tissues. RPIA is able to regulate liver cancer cell proliferation and colony formation ability via modulating protein phosphatase 2A (PP2A) and extracellular signal-regulated kinases (ERK) signaling pathway. We want to further examine the role of RPIA in cancer cells. Therefore, we applied i

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15

Descoteaux, Catherine. "Identification de régulateurs de la voie de signalisation du suppresseur tumoral PAR-4/LKB1 chez C. elegans." Thèse, 2015. http://hdl.handle.net/1866/13459.

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Le gène par-4 code pour une kinase à sérine/thréonine très conservée qui régule la polarisation précoce et la division cellulaire asymétrique de l’embryon de C. elegans. Une mutation de par-4 entraîne la létalité embryonnaire en perturbant trois processus: la ségrégation asymétrique des déterminants cellulaires, la régulation asynchrone de la progression du cycle cellulaire et la contractilité du réseau d’actomyosine. Pour identifier des régulateurs des voies de signalisation de PAR-4, nous avons procédé à un criblage pour des suppresseurs de la létalité embryonnaire associée à une mutation de

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16

Ching-ChiWu and 吳靜琪. "Identification of DNA Methylation Biomarkers for Prognosis Prediction and Characterization of Candidate Tumor Suppressor Gene SOX17 in Esophageal Squamous Cell Carcinoma." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/90664129693002913128.

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17

"Epigenetic identification of paired box gene 5 as a functional tumor suppressor associated with poor prognosis in patients with gastric cancer." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074868.

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Background & aims. DNA methylation induced tumor suppressor gene silencing plays an important role in carcinogenesis. By using methylation-sensitive representational difference analysis, we identified paired box gene 5 (PAX5) being methylated in human cancer. PAX5 locates at human chromosome 9p13.2 and encodes a 391 amino acids transcription factor. However, the role of PAX5 in gastric cancer is still unclear. Hence, we analyzed its epigenetic inactivation, biological functions, and clinical implications in gastric cancer.<br>Conclusions. Our results demonstrated that PAX5 promoter methylat

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18

"Identification of novel candidate tumor suppressor genes at 11q and 15q for esophageal squamous cell carcinoma and nasopharyngeal carcinoma via integrative cancer epigenetics and genomics." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074865.

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In brief, mRNA expression profiling of candidate genes in each locus was performed using semi-quantitative RT-PCR in a panel of ESCC and NPC cell lines, normal tissues and immortalized epithelial cell lines. Genes downregulated in cancer cells but with high expression in normal tissues and immortalized epithelial cells were subjected to promoter methylation analysis using methylation-specific PCR (MSP), bisulfite genomic sequencing (BGS) and pharmacological demethylation treatment. Genes with tumor-specific downregulation and methylation were further selected as candidates and their tumor supp

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19

Brechmann, Markus [Verfasser]. "Identification and characterization of protein phosphatase 4 regulatory subunit 1 (PP4R1) as a suppressor of NF-κB [NF-kappaB] in T-lymphocytes and T-cell lymphomas / presented by Markus Brechmann". 2010. http://d-nb.info/1007422769/34.

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20

Chuan-Hsiang and 許全翔. "Isolation, identification and analysis of the major antioxidant compounds in the flower of lychee (Litchi chinensis Sonn.) cultivated in Taiwan and their suppression for NO production in LPS-stimulated RAW 264.7 cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/35862631380687603649.

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碩士<br>中山醫學大學<br>應用化學系碩士班<br>99<br>Litchi (Litchi chinensis Sonn.) belonging to Sapindaceae family is one of the important commercial crops in Taiwan, which blooms in late March and fruit matures in late June. The flower is usually considered as disposable byproducts. Our pervious study found that acetone extract of litchi flower had a notable amount of phenol and also exhibited good antioxidant capacity. In the investigation, the acetone extract was further separated through liquid-liquid partition, silica gel column chromatography and Sephadex LH-20 column chromatography in turn. The amounts

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