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Artykuły w czasopismach na temat „Surfactant-Protein System - Biomolecular Devices”

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Data publikacji: 7 września 2023

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1

Montero-Jimenez, Marjorie, Francisco L. Amante, Gonzalo E. Fenoy, Juliana Scotto, Omar Azzaroni, and Waldemar A. Marmisolle. "PEDOT-Polyamine-Based Organic Electrochemical Transistors for Monitoring Protein Binding." Biosensors 13, no. 2 (2023): 288. http://dx.doi.org/10.3390/bios13020288.

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The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable the transduction of the biochemical event into a reliable electrical signal. In this work, PEDOT-polyamine blends are shown as versatile organic films that can act as both highly conducting channels of the transistors and non-denaturing platforms for the construction of the biomolecular architectures that operate as sensing surfaces. To achieve
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Espinosa, Francisco, Manuel Uhlig, and Ricardo Garcia. "Molecular Recognition by Silicon Nanowire Field-Effect Transistor and Single-Molecule Force Spectroscopy." Micromachines 13, no. 1 (2022): 97. http://dx.doi.org/10.3390/mi13010097.

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Silicon nanowire (SiNW) field-effect transistors (FETs) have been developed as very sensitive and label-free biomolecular sensors. The detection principle operating in a SiNW biosensor is indirect. The biomolecules are detected by measuring the changes in the current through the transistor. Those changes are produced by the electrical field created by the biomolecule. Here, we have combined nanolithography, chemical functionalization, electrical measurements and molecular recognition methods to correlate the current measured by the SiNW transistor with the presence of specific molecular recogn
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Cote, Sebastien, Delphine Bouilly, and Normand Mousseau. "The Electrostatic Gating of Carbon Nanotube Field-Effect Biosensors Characterized at the Molecular Scale Using Simulations." ECS Meeting Abstracts MA2022-01, no. 9 (2022): 721. http://dx.doi.org/10.1149/ma2022-019721mtgabs.

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Carbon nanotube field-effect biosensors (CNT-bioFETs) are ultraminiaturized devices that can be used to measure single-molecule kinetics of biomolecules on time scales going from a few microseconds to several minutes, as demonstrated for nucleic acid hybridization [1] and folding [2] as well as for enzyme function [3]. Experiments indicate that the sensitivity of CNT-bioFETs originates from the interplay between the nanotube’s conductance, which is monitored by the device, and the electrostatic potential generated by the biomolecule under investigation, which is localized on the nanotube [4,5]
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Samarentsis, Anastasios G., Alexandros K. Pantazis, Achilleas Tsortos, Jean-Michel Friedt, and Electra Gizeli. "Hybrid Sensor Device for Simultaneous Surface Plasmon Resonance and Surface Acoustic Wave Measurements." Sensors 20, no. 21 (2020): 6177. http://dx.doi.org/10.3390/s20216177.

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Surface plasmon resonance (SPR) and Love wave (LW) surface acoustic wave (SAW) sensors have been established as reliable biosensing technologies for label-free, real-time monitoring of biomolecular interactions. This work reports the development of a combined SPR/LW-SAW platform to facilitate simultaneous optical and acoustic measurements for the investigation of biomolecules binding on a single surface. The system’s output provides recordings of two acoustic parameters, phase and amplitude of a Love wave, synchronized with SPR readings. We present the design and manufacturing of a novel exper
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ZHANG, YONG. "INTEGRATION OF NANOPARTICLES WITH PROTEIN MICROARRAYS." International Journal of Nanoscience 05, no. 02n03 (2006): 189–94. http://dx.doi.org/10.1142/s0219581x0600422x.

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A variety of DNA, protein or cell microarray devices and systems have been developed and commercialized. In addition to the biomolecule related analysis, they are also being used for pharmacogenomic research, infectious and genetic disease and cancer diagnostics, and proteomic and cellular analysis.1 Currently, microarray is fabricated on a planar surface; this limits the amount of biomolecules that can be bounded on the surface. In this work, a planar protein microarray chip with nonplanar spot surface was fabricated to enhance the chip performance. A nonplanar spot surface was created by fir
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Firek, Piotr, Michal Cichomski, Michal Waskiewicz, Ireneusz Piwoński, and Aneta Kisielewska. "ISFET structures with chemically modified membrane for bovine serum albumin detection." Circuit World 44, no. 1 (2018): 45–50. http://dx.doi.org/10.1108/cw-10-2017-0061.

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Purpose The purpose of this paper is to present possibility of fast and certain identification of bovine serum albumin (BSA) by means of ion-sensitive field effect transistor (ISFET) structures. Because BSA can cause allergic reactions in humans, it is one of reasons for development of sensitive sensors to detect residual BSA. BSA is commonly used in biochemistry and molecular biology in laboratory experiments. Therefore, to better understand the mechanism of signal transduction in simulated biological environment and to elucidate the role of adsorption of biomolecules in the generation of a s
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Kasetsirikul, Surasak, Kimberley Clack, Muhammad J. A. Shiddiky, and Nam-Trung Nguyen. "Rapid, Simple and Inexpensive Fabrication of Paper-Based Analytical Devices by Parafilm® Hot Pressing." Micromachines 13, no. 1 (2021): 48. http://dx.doi.org/10.3390/mi13010048.

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Paper-based analytical devices have been substantially developed in recent decades. Many fabrication techniques for paper-based analytical devices have been demonstrated and reported. Herein, we report a relatively rapid, simple, and inexpensive method for fabricating paper-based analytical devices using parafilm hot pressing. We studied and optimized the effect of the key fabrication parameters, namely pressure, temperature, and pressing time. We discerned the optimal conditions, including a pressure of 3.8 MPa, temperature of 80 °C, and 3 min of pressing time, with the smallest hydrophobic b
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8

Ohshiro, Takahito, Yuki Komoto, and Masateru Taniguchi. "Single-Molecule Counting of Nucleotide by Electrophoresis with Nanochannel-Integrated Nano-Gap Devices." Micromachines 11, no. 11 (2020): 982. http://dx.doi.org/10.3390/mi11110982.

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We utilized electrophoresis to control the fluidity of sample biomolecules in sample aqueous solutions inside the nanochannel for single-molecule detection by using a nanochannel-integrated nanogap electrode, which is composed of a nano-gap sensing electrode, nanochannel, and tapered focusing channel. In order to suppress electro-osmotic flow and thermal convection inside this nanochannel, we optimized the reduction ratios of the tapered focusing channel, and the ratio of inlet 10 μm to outlet 0.5 μm was found to be high performance of electrophoresis with lower concentration of 0.05 × TBE (Tr
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9

Bhushan, Bharat, Kwang Joo Kwak, Samit Gupta, and Stephen C. Lee. "Nanoscale adhesion, friction and wear studies of biomolecules on silane polymer-coated silica and alumina-based surfaces." Journal of The Royal Society Interface 6, no. 37 (2008): 719–33. http://dx.doi.org/10.1098/rsif.2008.0398.

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Proteins on biomicroelectromechanical systems (BioMEMS) confer specific molecular functionalities. In planar FET sensors (field-effect transistors, a class of devices whose protein-sensing capabilities we demonstrated in physiological buffers), interfacial proteins are analyte receptors, determining sensor molecular recognition specificity. Receptors are bound to the FET through a polymeric interface, and gross disruption of interfaces that removes a large percentage of receptors or inactivates large fractions of them diminishes sensor sensitivity. Sensitivity is also determined by the distanc
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10

Kasoju, Naresh, Julian George, Hua Ye, and Zhanfeng Cui. "Sacrificial Core-Based Electrospinning: A Facile and Versatile Approach to Fabricate Devices for Potential Cell and Tissue Encapsulation Applications." Nanomaterials 8, no. 10 (2018): 863. http://dx.doi.org/10.3390/nano8100863.

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Electrospinning uses an electric field to produce fine fibers of nano and micron scale diameters from polymer solutions. Despite innovation in jet initiation, jet path control and fiber collection, it is common to only fabricate planar and tubular-shaped electrospun products. For applications that encapsulate cells and tissues inside a porous container, it is useful to develop biocompatible hollow core-containing devices. To this end, by introducing a 3D-printed framework containing a sodium chloride pellet (sacrificial core) as the collector and through post-electrospinning dissolution of the
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11

Lee, Ju Seok, Joon Jin Song, Russell Deaton, and Jin-Woo Kim. "Assessing the Detection Capacity of Microarrays as Bio/Nanosensing Platforms." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/310461.

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Microarray is one of the most powerful detection systems with multiplexing and high throughput capability. It has significant potential as a versatile biosensing platform for environmental monitoring, pathogen detection, medical therapeutics, and drug screening to name a few. To date, however, microarray applications are still limited to preliminary screening of genome-scale transcription profiling or gene ontology analysis. Expanding the utility of microarrays as a detection tool for various biological and biomedical applications requires information about performance such as the limits of de
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12

Roth, Shira, Michael Margulis, and Amos Danielli. "Recent Advances in Rapid and Highly Sensitive Detection of Proteins and Specific DNA Sequences Using a Magnetic Modulation Biosensing System." Sensors 22, no. 12 (2022): 4497. http://dx.doi.org/10.3390/s22124497.

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In early disease stages, biomolecules of interest exist in very low concentrations, presenting a significant challenge for analytical devices and methods. Here, we provide a comprehensive overview of an innovative optical biosensing technology, termed magnetic modulation biosensing (MMB), its biomedical applications, and its ongoing development. In MMB, magnetic beads are attached to fluorescently labeled target molecules. A controlled magnetic force aggregates the magnetic beads and transports them in and out of an excitation laser beam, generating a periodic fluorescent signal that is detect
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13

Jia, Xiao, Yang Liu, Yanmei Yang, et al. "Exploring the biotoxicity of carbon boride nanosheets (BC3) based on the villin headpiece protein model." Journal of Physics D: Applied Physics 55, no. 17 (2022): 175403. http://dx.doi.org/10.1088/1361-6463/ac4d4c.

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Abstract The recently synthesized single-layer carbon boride (BC3), has been explored for biomedical applications. However, the interaction between BC3 and biomolecules needs to be further explored to evaluate its potential toxicity to biological systems. Here, using the villin headpiece (HP35) as a representative protein model, the binding behavior of proteins to BC3 and the structure evolution of proteins were studied by molecular dynamics simulation. Our data revealed that HP35 can quickly load and form stable binding to BC3 surface. The BC3 caused moderate destruction of the HP35 by destro
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14

Demirhan, Alper, Ece Eksin, Yalin Kilic, and Arzum Erdem. "Low-Cost High-Resolution Potentiostat for Electrochemical Detection of Nucleic Acids and Biomolecular Interactions." Micromachines 13, no. 10 (2022): 1610. http://dx.doi.org/10.3390/mi13101610.

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A handheld USB-powered instrument developed for the electrochemical detection of nucleic acids and biomolecular interactions is presented. The proposed instrument is capable of scanning ± 2.25 V while measuring currents up to ±10 mA, with a minimum current resolution of 6.87 pA. Therefore, it is suitable for nucleic acid sensors, which have high background currents. A low-cost microcontroller with an on-chip 16-bit analog-to-digital converter, 12-bit digital-to-analog converter, and a built-in USB controller were used to miniaturize the system. The offset voltages and gain errors of the analog
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15

Sitkov, Nikita, Andrey Ryabko, Alexey Kolobov, et al. "Impedimetric Biosensor Coated with Zinc Oxide Nanorods Synthesized by a Modification of the Hydrothermal Method for Antibody Detection." Chemosensors 11, no. 1 (2023): 66. http://dx.doi.org/10.3390/chemosensors11010066.

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Impedimetric biosensors are used for detecting a wide range of analytes. The detection principle is a perspective for the development of new types of analytical devices for biomolecular diagnosis of diseases. Of particular interest are biosensors with very high sensitivities, capable of detecting trace amounts of biomarkers or drugs in biological fluids. Impedimetric biosensors possess a potential for increased sensitivity, since their electrodes can be modified with nanostructured materials, in particular zinc oxide. In this work, a miniature biosensor with an array of zinc oxide nanorods syn
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16

Wan Ahamad, Wan Mohd Azwady, Dzaraini Kamarun, Mohd Kamil Abd Rahman, and Mohamad Shukri Kamarudin. "Modular Surface Plasmon Resonance (SPR) Biosensor Based on Wavelength Modulation." Advanced Materials Research 1107 (June 2015): 699–705. http://dx.doi.org/10.4028/www.scientific.net/amr.1107.699.

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This paper deals with a new invention of modular surface plasmon resonance (SPR) biosensor device based on wavelength modulation wherein the angle of incidence of the light source is fixed and the shift in wavelength at resonance is monitored. This device is capable of detecting biomolecular binding interactions of different species such as protein and viruses based on changes in the refractive index of the dielectric environment. White light source mounted with a polarizer is used to excite plasmons on the sensor surface which is thin gold film of ~21 μm thickness coated on BK-7 glass. A vari
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Wibowo, Nur Aji, Harsojo, and Edi Suharyadi. "Prospect of core-shell Fe3O4@Ag label integrated with spin-valve giant magnetoresistance for future point-of-care biosensor." Advances in Natural Sciences: Nanoscience and Nanotechnology 12, no. 4 (2021): 045013. http://dx.doi.org/10.1088/2043-6262/ac498e.

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Abstract Magnetic-based biosensors are the analytical instruments that convert the biological recognition into the electrical signal through the generating of the stray-field of the magnetic nanoparticles (MNPs) attached to the biomolecule target. The magnetic biosensor feature relies on the transducer and the MNPs label selection. Recently, the biosensor with a point-of-care feature is the most expected device in the nowadays medical diagnostic field. So that, a review of the recent research related to the novel integration of magnetoresistance-based transducers with MNPs for biosensor applic
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18

Akgönüllü, Semra, Erdoğan Özgür, and Adil Denizli. "Quartz Crystal Microbalance-Based Aptasensors for Medical Diagnosis." Micromachines 13, no. 9 (2022): 1441. http://dx.doi.org/10.3390/mi13091441.

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Aptamers are important materials for the specific determination of different disease-related biomarkers. Several methods have been enhanced to transform selected target molecule-specific aptamer bindings into measurable signals. A number of specific aptamer-based biosensors have been designed for potential applications in clinical diagnostics. Various methods in combination with a wide variety of nano-scale materials have been employed to develop aptamer-based biosensors to further increase sensitivity and detection limit for related target molecules. In this critical review, we highlight the
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19

Vogel, Viola. "Reverse Engineering: Learning from Proteins How to Enhance the Performance of Synthetic Nanosystems." MRS Bulletin 27, no. 12 (2002): 972–78. http://dx.doi.org/10.1557/mrs2002.304.

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AbstractProteins are nature's workhorses. They enable living systems to use available energy sources and convert energy from one form into another. Understanding the underlying design principles of how proteins have evolved to fulfill the necessary functions of life can provide researchers with new insights into how to enhance the performance of synthetic nanosystems with far greater sophistication. This review summarizes the relationship between various protein functions and the underlying engineering principles of their overall structures. For example, proteins can specifically recognize oth
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Kontziampasis, Dimitrios, David P. Klebl, Matthew G. Iadanza, et al. "A cryo-EM grid preparation device for time-resolved structural studies." IUCrJ 6, no. 6 (2019): 1024–31. http://dx.doi.org/10.1107/s2052252519011345.

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Structural biology generally provides static snapshots of protein conformations that can provide information on the functional mechanisms of biological systems. Time-resolved structural biology provides a means to visualize, at near-atomic resolution, the dynamic conformational changes that macromolecules undergo as they function. X-ray free-electron-laser technology has provided a powerful tool to study enzyme mechanisms at atomic resolution, typically in the femtosecond to picosecond timeframe. Complementary to this, recent advances in the resolution obtainable by electron microscopy and the
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Pancera, S. M., H. Gliemann, D. F. S. Petri, and T. Schimmel. "Adsorption Behaviour of Creatine Phosphokinase onto Silicon Wafers: Comparison between Ellipsometric and Atomic Force Microscopy Data." Microscopy and Microanalysis 11, S03 (2005): 56–60. http://dx.doi.org/10.1017/s1431927605050889.

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Protein adsorption plays a major role in a variety of important technological and biological processes [1-2] and the understanding of the fundamental factors that determine protein adsorption are imperative to the development of biocompatible materials and biotechnological devices [3-4] as for example biosensors [5]. The adsorption of proteins on surfaces is a complex process. Due to the large size and different shapes of these adsorbing particles, the interactions between the adsorbed proteins on the surface can be strongly influentiated by the fact that the particles may undergo conformation
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Fuku, Xolile, Abdoulaye Diallo, and Malik Maaza. "Nanoscaled Electrocatalytic Optically Modulated ZnO Nanoparticles through Green Process ofPunica granatumL. and Their Antibacterial Activities." International Journal of Electrochemistry 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/4682967.

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Most recently, green synthesis of metal oxide nanoparticles has become an interesting subject of the nanoscience and nanotechnology. The use of plant systems has been deemed a green route and a dependable method for nanoparticle biosynthesis, owing to its environmental friendly nature. The present work demonstrates the bioreductive green synthesis of nanosized zinc oxide (ZnO) using peel extracts of pomegranate. Highly crystalline ZnO nanoparticles (ZnO NPs) which are 5 nm in particle size were characterised by HRTEM and XRD. FT-IR spectra confirmed the presence of the biomolecules and formati
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Serrano-De la Rosa, Laura, Abel Moreno, and Mauricio Pacio. "Electro-Infiltration of Cytochrome C into a Porous Silicon Network, and Its Effect on Nucleation and Protein Crystallization—Studies of the Electrical Properties of Porous Silicon Layer-Protein Systems for Applications in Electron-Transfer Biomolecular Devices." Crystals 7, no. 7 (2017): 194. http://dx.doi.org/10.3390/cryst7070194.

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Marvi, Fahimeh, and Kian Jafari. "A label-free biomarkers detection platform relied on a bilayer long-wave infrared metamaterials BioNEMS sensor." Nanotechnology 33, no. 26 (2022): 265502. http://dx.doi.org/10.1088/1361-6528/ac5ee1.

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Abstract A novel approach based on optical Biological-Nano-Electro-Mechanical-Systems (BioNEMS) sensor is presented in this paper to provide highly sensitive and precise detection of biomolecules. The proposed BioNEMS sensor is relied on a bi-layer metamaterials structure, tuned by its wavelength. The presented biosensor consists of a BioNEMS membrane coated by Complementary Split Ring Resonators and an array of Split Ring Resonators cells on the substrate. While the immobilized bioreceptors adsorb the biomarkers (i.e. mRNA or protein), it causes a bending of the suspended membrane. This is du
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Montdargent, Béatrice, and Didier Letourneur. "Toward New Biomaterials." Infection Control & Hospital Epidemiology 21, no. 6 (2000): 404–10. http://dx.doi.org/10.1086/501782.

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Polymers are widely used for a large range of medical devices used as biomaterials on a temporary, intermittent, and long-term basis. It is now well accepted that the initial rapid adsorption of proteins to polymeric surfaces affects the performance of these biomaterials. However, protein adsorption to a polymer surface can be modulated by an appropriate design of the interface. Extensive study has shown that these interactions can be minimized by coating with a highly hydrated layer (hydrogel), by grafting on the surface different biomolecules, or by creating domains with chemical functions (
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26

Zanut, Alessandra, Alessandro Cian, Nicola Cefarin, Alessandro Pozzato, and Massimo Tormen. "Nanoelectrode Arrays Fabricated by Thermal Nanoimprint Lithography for Biosensing Application." Biosensors 10, no. 8 (2020): 90. http://dx.doi.org/10.3390/bios10080090.

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Electrochemical sensors are devices capable of detecting molecules and biomolecules in solutions and determining the concentration through direct electrical measurements. These systems can be miniaturized to a size less than 1 µm through the creation of small-size arrays of nanoelectrodes (NEA), offering advantages in terms of increased sensitivity and compactness. In this work, we present the fabrication of an electrochemical platform based on an array of nanoelectrodes (NEA) and its possible use for the detection of antigens of interest. NEAs were fabricated by forming arrays of nanoholes on
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Wu, Bingchen, Elisa Castagnola, and Xinyan Tracy Cui. "Zwitterionic Polymer Coated and Aptamer Functionalized Flexible Micro-Electrode Arrays for In Vivo Cocaine Sensing and Electrophysiology." Micromachines 14, no. 2 (2023): 323. http://dx.doi.org/10.3390/mi14020323.

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The number of people aged 12 years and older using illicit drugs reached 59.3 million in 2020, among which 5.2 million are cocaine users based on the national data. In order to fully understand cocaine addiction and develop effective therapies, a tool is needed to reliably measure real-time cocaine concentration and neural activity in different regions of the brain with high spatial and temporal resolution. Integrated biochemical sensing devices based upon flexible microelectrode arrays (MEA) have emerged as a powerful tool for such purposes; however, MEAs suffer from undesired biofouling and
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Ma, Gang, Jian Liu, Li Fu, and Elsa C. Y. Yan. "Probing Water and Biomolecules at the Air—Water Interface with a Broad Bandwidth Vibrational Sum Frequency Generation Spectrometer from 3800 to 900 cm−1." Applied Spectroscopy 63, no. 5 (2009): 528–37. http://dx.doi.org/10.1366/000370209788347057.

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We have built a broad bandwidth vibrational sum frequency generation (VSFG) spectrometer that can provide high-quality spectra over the range of 3800 to 900 cm−1. The spectrometer contains a commercial Ti:sapphire based 6 W regenerative amplifier as the master light source, a home-built pulse shaper to produce a narrow bandwidth 800 nm beam, a commercial optical parametric amplifier to generate a broad bandwidth femtosecond infrared (IR) pulse, and a detection system with a monochromator and a charge-coupled device (CCD). We applied this spectrometer to obtain VSFG spectra of a lipid monolayer
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BOYES, STEPHEN G., MISTY D. ROWE, NATALIE J. SERKOVA, FERNANDO J. KIM, JAMES R. LAMBERT, and PRIYA N. WERAHERA. "POLYMER-MODIFIED GADOLINIUM NANOPARTICLES FOR TARGETED MAGNETIC RESONANCE IMAGING AND THERAPY." Nano LIFE 01, no. 03n04 (2010): 263–75. http://dx.doi.org/10.1142/s1793984410000250.

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Functional imaging is a novel area in radiological sciences and allows for the non-invasive assessment and visualization of specific targets such as gene and protein expression, metabolic rates, and drug delivery in intact living subjects. As such, the field of molecular imaging has been defined as the non-invasive, quantitative, and repetitive imaging of biomolecules and biological processes in living organisms. For example, cancer cells may be genetically altered to attract molecules that alter the magnetic susceptibility, thereby permitting their identification by magnetic resonance imaging
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Zhang, Wenxian, Zhenzhen Chen, Yang Shi, Jiaqi Wang, and Jingjing Zhang. "Integration of CRISPR/Cas with functional nucleic acids as versatile toolbox for non-nucleic acid target diagnostics: a review." Flexible and Printed Electronics 8, no. 2 (2023): 023002. http://dx.doi.org/10.1088/2058-8585/ace0cb.

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Abstract Non-nucleic acid targets, consisting primarily of metal ions, organic small molecules and proteins. They act as important biomolecules or cell surface markers, supplying integrated and comprehensive bio-diagnostic information for the early diagnosis and treatment of diseases. Meanwhile, the analysis of non-nucleic acid targets also offers the foundation for individualized medicine and precision therapy. Therefore, a versatile platform for non-nucleic acid targets requires development. Clustered regularly interspaced short palindromic repeats-associated protein (CRISPR/Cas) systems is
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Gurukandure, Asanka, Kacey G. Ortiz, Rashad R. Karimov, and Christopher J. Easley. "Electrochemical Sensing of Cortisol in Human Saliva and Serum Using DNA-Steroid Conjugation with a Versatile DNA Nanostructure Sensor." ECS Meeting Abstracts MA2022-02, no. 61 (2022): 2270. http://dx.doi.org/10.1149/ma2022-02612270mtgabs.

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Having a generalizable point of care (POC) method for clinically relevant biomolecules would greatly enhance healthcare management and disease diagnosis. Recently our group developed a novel DNA nanostructure architecture for versatile detection of analytes which is generalizable for assaying several small molecules and their larger protein binding partners (e.g. antibodies) in human serum. The DNA nanostructure is built through on-electrode enzymatic ligation of three oligos for electrode attachment, anchor binding, and electrochemical signaling. In this study, we developed an economical synt
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Correira, Joshua M., Paul R. Handali, and Lauren J. Webb. "Characterizing Protein-Surface and Protein-Nanoparticle Conjugates: Activity, Binding, and Structure." Journal of Chemical Physics, August 5, 2022. http://dx.doi.org/10.1063/5.0101406.

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Many sensors and catalysts composed of proteins immobilized on inorganic materials have been reported over the past few decades. Despite some examples of functional protein-surface and protein-nanoparticle conjugates, thorough characterization of the biological-abiological interface at the heart of these materials and devices is often overlooked in lieu of demonstrating acceptable system performance. This has resulted in a focus on generating functioning protein-based devices without a concerted effort to develop reliable tools necessary to measure the fundamental properties of the bio-abio in
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Naraprawatphong, Rinyarat, Genta Kawanaka, Masayoshi Hayashi, Akifumi Kawamura, and Takashi Miyata. "Development of protein-recognition SPR devices by combination of SI-ATRP with biomolecular imprinting using protein ligands." Molecular Imprinting 4, no. 1 (2016). http://dx.doi.org/10.1515/molim-2016-0003.

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AbstractMolecularly imprinted polymer brush layers and gel layers with both a lectin (ConA) and an antibody-IgG as biomolecular ligands for a target protein were formed on surface plasmon resonance (SPR) sensor chips via surface-initiated atom transfer radical polymerization (SIATRP) without and with a crosslinker, respectively. While the IgG-imprinted brush layers chip had almost the same affinity constant for target IgG as the nonimprinted brush layer chip, the affinity constant of the IgG-imprinted gel layer chip was approximately twice than that of the nonimprinted gel layer chip. These in
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"Precision Nanomedicine Vol. 3, Issue 1 Table of Contents." Precision Nanomedicine 3, no. 1 (2020). http://dx.doi.org/10.33218/prnano3(1).toc.

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Hunziker P. et al.: Schistosomiasis: from established diagnostic assays to emerging micro/nanotechnology-based rapid field testing for clinical management and epidemiology Precis. Nanomed. 2020 January;3(1):439-458 POTENTIAL CLINICAL SIGNIFICANCE Abstract Schistosomiasis is a neglected invasive worm disease with a huge disease burden in developing countries, particularly in children, and is seen increasingly in non-endemic regions through transfer by travellers, expatriates, and refugees. Undetected and untreated infections may be responsible for the persistence of transmission. Rapid and accu
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Romero-Muñiz, C., J. G. Vilhena, R. Pérez, J. C. Cuevas, and L. A. Zotti. "Recent Advances in Understanding the Electron Transport Through Metal-Azurin-Metal Junctions." Frontiers in Physics 10 (July 4, 2022). http://dx.doi.org/10.3389/fphy.2022.950929.

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Azurin proteins are the workhorse of protein electronics. This is a branch of biomolecular electronics, a recent research field which investigates electronics based on biomolecules such as proteins, peptides, amino acids, bacterial nanowires or DNA. In general, the possibility of including biosystems in solid-state junctions has opened the way to the development of novel electrical devices, and proteins have attracted enormous attention thanks to their many interesting properties. In the particular case of metal-azurin-metal junctions, experimental measurements have revealed extremely efficien
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Teker, Kasif. "A Scheme for Blocking Non-Specific Antibody Binding on Single Wall Carbon Nanotubes." MRS Proceedings 1092 (2008). http://dx.doi.org/10.1557/proc-1092-bb02-07.

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AbstractCarbon nanotubes have many unique properties such as high surface area, hollow cavities, and excellent mechanical and electrical properties. Interfacing carbon nanotubes with biological systems could lead to significant applications in various disease diagnoses. Significant progress in interfacing carbon nanotubes with biological materials has been made in key areas such as aqueous solubility, chemical and biological functionalization for biocompatibility and specificity, and electronic sensing of proteins. Bioconjugated nanotubes combined with the sensitive nanotube-based electronic d
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Ho, Dean, Benjamin Chu, Hyeseung Lee, Karen Kuo, and Carlo D. Montemagno. "Block Copolymer-Based Biomembranes Functionalized with Energy Transduction Proteins." MRS Proceedings 823 (2004). http://dx.doi.org/10.1557/proc-823-w11.8.

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AbstractBlock copolymer-based membranes can be functionalized with energy transducing proteins to reveal a versatile family of nanoscale materials. Our work has demonstrated the fabrication of protein-functionalized ABA triblock copolymer nanovesicles that possess a broad applicability towards areas like biosensing and energy production. ABA triblock copolymers possess certain advantages over lipid systems. For example, they can mimic biomembrane environments necessary for membrane protein refolding in a single chain (hydrophilic(A)- hydrophobic(B)-hydrophilic(A)), enabling large-area membrane
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Dey, Swarup, Adam Dorey, Leeza Abraham, et al. "A reversibly gated protein-transporting membrane channel made of DNA." Nature Communications 13, no. 1 (2022). http://dx.doi.org/10.1038/s41467-022-28522-2.

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AbstractControlled transport of biomolecules across lipid bilayer membranes is of profound significance in biological processes. In cells, cargo exchange is mediated by dedicated channels that respond to triggers, undergo a nanomechanical change to reversibly open, and thus regulate cargo flux. Replicating these processes with simple yet programmable chemical means is of fundamental scientific interest. Artificial systems that go beyond nature’s remit in transport control and cargo are also of considerable interest for biotechnological applications but challenging to build. Here, we describe a
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Turhan, Berk, and Zeynep H. Gümüş. "A Brave New World: Virtual Reality and Augmented Reality in Systems Biology." Frontiers in Bioinformatics 2 (April 6, 2022). http://dx.doi.org/10.3389/fbinf.2022.873478.

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How we interact with computer graphics has not changed significantly from viewing 2D text and images on a flatscreen since their invention. Yet, recent advances in computing technology, internetworked devices and gaming are driving the design and development of new ideas in other modes of human-computer interfaces (HCIs). Virtual Reality (VR) technology uses computers and HCIs to create the feeling of immersion in a three-dimensional (3D) environment that contains interactive objects with a sense of spatial presence, where objects have a spatial location relative to, and independent of the use
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Rocha, Igor, Gabrielle Cerqueira, Felipe Varella Penteado, and Susana I. Córdoba de Torresi. "Electrical Stimulation and Conductive Polymers as a Powerful Toolbox for Tailoring Cell Behaviour in vitro." Frontiers in Medical Technology 3 (July 29, 2021). http://dx.doi.org/10.3389/fmedt.2021.670274.

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Electrical stimulation (ES) is a well-known method for guiding the behaviour of nerve cells in in vitro systems based on the response of these cells to an electric field. From this perspective, understanding how the electrochemical stimulus can be tuned for the design of a desired cell response is of great importance. Most biomedical studies propose the application of an electrical potential to cell culture arrays while examining the cell response regarding viability, morphology, and gene expression. Conversely, various studies failed to evaluate how the fine physicochemical properties of the
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