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Rozprawy doktorskie na temat „Synaptic behaviour”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Joshi, Abhilasha. "Behaviour-dependent activity and synaptic organisation of septo-hippocampal GABAergic neurons." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:28b4b2bc-f782-4bc9-87af-233527171e60.

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Animal behaviour is coordinated by biological rhythms over multiple timescales. In the temporal cortex, rhythmic oscillatory activity in the 5 to 12 Hz theta frequency range supports behaviour through temporal windows of changes in excitability and circuit computation. Subcortical inputs, including those from the medial septum are thought to generate the theta oscillatory activity. However, the rules of innervation of identified types of cortical cells in different cortical regions by a diverse population of septal neurons are largely unknown. During my DPhil studies, I tested the hypothesis t

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King, Tanya Margaret. "Correlates between learning and the properties of the IMHV in vitro." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294374.

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VOLTA, Mattia. "Leucine-rich repeat kinase 2, synaptic morphology and motor behavior." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389441.

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Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are known to cause late-onset, familial forms of Parkinson’s Disease, with prevalence up to 40% in specific populations. These mutations are also linked to sporadic PD, highlighting the importance of the related protein in the development of the disease. LRRK2 is a large, complex, multi-domain protein, with two main enzymatic activities: a GTPase domain (bearing three pathogenic mutations) and a kinase domain, in which the most common mutation (G2019S) is found. Even though the precise cellular functions of LRRK2 are not known, LRRK2

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4

Jučaité, Aurelija. "Attention-deficit/hyperactivity disorder - alterations of motor behaviour and dopaminergic transmission /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-968-4.

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Panopoulou, Myrto [Verfasser]. "Cocaine-induced synaptic changes in the nucleus accumbens: role in drug-motivated behaviour and relapse risk / Myrto Panopoulou." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1233865757/34.

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Wong, Andrew Wai Kit. "Correlations between hippocampal synaptic plasticities and proteins, in inbred mice and in transgenic mice modelling Alzheimer's disease, and behaviour." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408247.

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Katona, Linda. "The role of cell-type selective synaptic connections in rhythmic neuronal network activity in the hippocampus." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:cebe42e9-4040-486b-8ff4-fa1bf642bea0.

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Olusakin, Jimmy. "Serotonin and emotional behaviours : developmental role of the 5-HT7 receptor Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS287.

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Les antidépresseurs qui bloquent le transporteur de sérotonine (Slc6a4 / SERT) améliorent l'humeur chez l'adulte, mais ont des effets paradoxaux sur le développement à long terme, augmentant le risque de développer l'anxiété et la dépression. La base de cet effet sur le développement n'est pas connue. Dans une étude précédente, nous avions identifié une sous-population de neurones pyramidaux de la couche corticale préfrontal 5 (PFC) qui exprimaient de manière transitoire le SERT au cours d'une période postnatale précoce chez la souris (P0 - P10). Ces neurones PFC-SERT + établissent des synapse

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9

Scholey, Andrew Belton. "Immunological investigations into synaptic plasticity." Thesis, Open University, 1991. http://oro.open.ac.uk/57339/.

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Antibody technology was applied to the study of synaptic plasticity resulting from passive avoidance training in the chick and long-term potentiation in the rat. These studies fell into three categories: 1) the disruption of memory for a one-trial passive avoidance task by intracranial injection of an anti-postsynaptic density antiserum 2) mapping time- and locus-specific changes in the chick brain using antisera to the cytoskeletal proteins (Xtubulin and microtubule-associated protein 2 following passive avoidance training and 3) using antibodies to synaptically-enriched antigens to map time-

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Torres, Herráez Arturo. "Electrophysiological characterization of cerebello-hippocampal interaction in mice across behavioural states." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS391.

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L’implication du cervelet dans la cognition et navigation spatiale a été récemment remarqué par l’équipe de Rondi Reig chez l’homme et dans modèles murines. Également, ces études suggérèrent fortement que le cervelet interagit avec l’hippocampe dans un réseau fonctionnel. Cependant, à ce jour il nous manque d’information relative sur le substrat anatomique et les mécanismes physiologiques qui permet cette interaction. Cette information est fondamentale pour comprendre le rôle du cervelet dans ces fonctions et il a constitué le sujet de ma thèse. À cette fin, nous avons employé une combinaison

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11

Brioschi, Simone [Verfasser], and Dierk Frithjof [Akademischer Betreuer] Reiff. "Microglia promote synaptic loss and depressive-like behavior under chronic-stress exposure." Freiburg : Universität, 2019. http://d-nb.info/118819593X/34.

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O'Brien, Megan A. "Investigating the Role of the Synaptic Transcriptome in Ethanol-Responsive Behaviors." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3570.

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Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, compulsion to seek and imbibe ethanol, and chronic craving and relapse. It is suggested that the characteristic behaviors associated with the escalation of drug use are caused by long-term molecular adaptations precipitated by the drug’s continual administration. These lasting activity-dependent changes that underlie addiction-associated behavior are thought, in part, to depend on new protein synthesis and remodeling at the synapses. It is well established that mRNA can be transported to neuronal

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13

Khlghatyan, Jivan, and Jivan Khlghatyan. "Regulation of glutamatergic neurotransmission, synaptic plasticity, sleep and behavior by D2-GSK3B-FXR1." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/38090.

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Les études GWAS associent les variantes du gène Fxr1 à la schizophrénie, les maladies bipolaires, l’insomnie et la durée du sommeil. Gsk3β peut directement phosphoryler et ainsi réguler négativement Fxr1. De plus, les interactions fonctionnelles entre Gsk3β et Fxr1 sont associées avec la stabilité émotionnelle chez les humains. Comment Gsk3β-Fxr1 régule l’activité neuronale, la plasticité et le comportement reste inconnu. Gsk3β peut être activé en aval des récepteurs D2 de dopamine. L’activité de Gsk3β peut être modulée par les stabilisateurs d’humeur, les antipsychotiques et les antidépresseu

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14

Redondo, Pena Roger Lluis. "Tagging and capture hypothesis of synaptic plasticity : the roles of calmodulin kinases and the phenomenon of behavioural tagging." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4421.

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The aims of this thesis were (1) to learn about the identities of the molecules involved in the maintenance of long-term potentiation (LTP), and (2) to develop and test a behavioural paradigm capable of elucidating the interaction between these molecular processes and the persistence of long-term memories. By improving the stability of field recordings in in vitro electrophysiology, it was possible to investigate the molecular processes that determine the long-term changes in synaptic efficacy. In these experiments, the interactions between two convergent inputs onto the same neuronal populati

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15

Sowers, Levi Paul. "Humans and Mice with Prickle Mutations Show a Propensity for Epilepsy and Display Autism-Like Behaviors with Evidence for Hippocampal Synaptic Dysfunction." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/4914.

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The synapse is essential for normal neuronal communication and synaptic abnormalities could underlie many neuronal pathologies leading to such diseases as epilepsy and autism. Recent reports suggest that the Wnt signaling pathway is essential for normal synaptic development and function. However the role of specific Wnt ligands and their downstream signaling molecules play in synapse formation and function remain unclear. PRICKLE1 (PK1) and PRICKLE2 (PK2) are downstream Wnt signaling molecules which are suggested to play essential roles in neuronal function. PK1 was recently shown to be mutate

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16

Kloster, Alix H. "A high fructose diet alters affective-like behavior and metrics of synaptic mitochondrial function differentially in male and female rats." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5824.

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Fructose consumption has become a normalized part of the standard American diet over the past 40 years. While fructose consumption is a known risk factor of metabolic syndrome, there is increasing evidence that fructose consumption influences brain and behavior. Recently, more interest has been focused on mitochondrial dysfunction as a potential link between metabolic stress and modifications of the central nervous system. Mitochondria are in the unique position of both regulating and being vulnerable to alterations in energy homeostasis. Sex-differences are well categorized in the presentatio

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17

SEPMAN, HELENA. "Role of type 1 cannabinoid receptors in synaptic and behavioural alterations associated to experimental model of multiple sclerosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203128.

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Cannabinoid receptors type 1 (CB1R) are important regulators of the neurodegenerative damage in multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis (EAE). In GABAergic striatal neurons, CB1R stimulation exerts protective effects by limiting inflammation-induced potentiation of glutamate-mediated spontaneous excitatory postsynaptic currents (sEPSCs). Mood disorders, including anxiety and depression, are frequently diagnosed in MS patients, even independently of the disabling symptoms associated with the disease. Anatomical, biochemical, and pharmacological ev

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18

Ziminski, Joseph. "Intrinsic and synaptic adaptations in neuronal ensembles following recall of appetitive associative memories : investigations in the striatum and prefrontal cortex with the Fos-GFP mouse." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/74246/.

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Learned associations between rewarding stimuli and environmental cues which predict their availability play an important role in guiding behaviour. These learned associations are thought to be encoded by neuroadaptations in disperse sets of strongly activated neurons, termed neuronal ensembles, located throughout motivationally-relevant brain areas. However to date, the nature of the adaptations which occur selectively on neuronal ensembles encoding appetitive associative memories remain largely unknown. Using the Fos-GFP mouse, which expresses green fluorescent protein (GFP) in recently activ

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19

Katsanevaki, Danai. "Cortical circuit and behavioural pathophysiology in rodent models of SYNGAP1 haploinsufficiency." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31062.

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SYNGAP1 haploinsufficiency is one of the most common monogenic causes of nonsyndromic moderate to severe intellectual disability (NSID) and autism (Hamdan et al., 2009; Pinto et al., 2010). De novo truncating or frameshift mutations in the SYNGAP1 gene lead to the loss of the encoded protein Synaptic GTPase activating protein (SynGAP), one of the most abundant of postsynaptic proteins (Hamdan et al., 2011). SynGAP, present at excitatory and inhibitory synapses (Kim et al., 1998), acts as a key regulator of highly conserved signaling pathways linked to AMPA- and NMDA-receptor dependent plastici

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Perna, Marla K. "The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etd/1432.

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Schizophrenia affects about 1% of the population. A hallmark of the disorder is increased dopamine D2 receptor sensitivity in the brain. Studies have shown that schizophrenics smoke cigarettes at approximately 4 times the rate of the general population. It has been suggested that nicotine use is a form of self-medication for symptoms in schizophrenia. Smoking behaviors typically begin in adolescence. We assessed effects of nicotine on behavior and brain plasticity in an adolescent rodent model of schizophrenia with the goal of identifying targets for smoking cessation. Methods: Rats were neona

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21

Pais, Gomes Luís Catarina [Verfasser], and Georg [Akademischer Betreuer] Köhr. "Linking addiction-related behavior to synaptic efficacy and network activity in the prefrontal-accumbal pathway of behaving rats / Catarina Pais Gomes Luís ; Betreuer: Georg Köhr." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1182317995/34.

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Shukla, Avani Verfasser], Oliver [Akademischer Betreuer] [Gutachter] Schlüter, and Tobias [Gutachter] [Moser. "Cocaine-induced synaptic plasticity in the nucleus accumbens and drug-associated behavior - An unexpected dissociation / Avani Shukla. Betreuer: Oliver Schlüter. Gutachter: Oliver Schlüter ; Tobias Moser." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1102535869/34.

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Luís, Catarina [Verfasser], and Georg [Akademischer Betreuer] Koehr. "Linking addiction-related behavior to synaptic efficacy and network activity in the prefrontal-accumbal pathway of behaving rats / Catarina Pais Gomes Luís ; Betreuer: Georg Köhr." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-243554.

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Lanza, Giuseppe. "Identification of early neurophysiological markers related to cognitive-behavioural disorders and progression of Vascular Cognitive Impairment: a Transcranial Magnetic Stimulation study." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/3932.

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Transcranial magnetic stimulation (TMS) highlighted functional changes in dementia, whereas there are few data in patients with Vascular Cognitive Impairment No Dementia (VCI-ND) at risk for cognitive worsening. Similarly, little is known about the neurophysiological impact of Vascular Depression (VD) on deterioration of cognitive functions. We performed a longitudinal TMS study to test whether the presence of depression might affect not only cognition but also the functioning of specific cortical circuits in patients with subcortical vascular damage. In this study, 16 VCI-ND and 11 VD patient

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Cardona, Alberich Aida [Verfasser], and Kent [Akademischer Betreuer] Duncan. "In vivo genome-wide analysis reveals that eIF2D coordinates motor neuronal synaptic function and locomotion behavior by regulating translation of specific mRNAs / Aida Cardona Alberich ; Betreuer: Kent Duncan." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1187444766/34.

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Steuer, Costa Wagner Verfasser], Alexander [Gutachter] Gottschalk, Martin [Gutachter] Grininger, Amparo [Gutachter] [Acker-Palmer, Bernd Gutachter] Ludwig, and Tobias [Gutachter] [Moser. "Neuropeptidergic control of synaptic vesicle filling and behavior in the nematode "Caenorhabditis elegans" / Wagner Steuer Costa ; Gutachter: Alexander Gottschalk, Martin Grininger, Amparo Acker-Palmer, Bernd Ludwig, Tobias Moser." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/114854822X/34.

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Cheung, Amy. "The Role of Neurexins in Serotonin Signaling and Complex Behaviors." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1134.

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Extensive serotonin (5-HT) fiber innervation throughout the brain corroborates 5-HT’s modulatory role in numerous behaviors including social behavior, emotion regulation, and learning and memory. Abnormal brain 5-HT levels and function are implicated in Autism Spectrum Disorder (ASD) which often co-occurs with other neuropsychiatric conditions. While 5-HT therapeutics are used to treat ASD, variable improvements in symptomatology require further investigation of 5-HT-mediated pathology. Neurexins (Nrxns) are presynaptic cell adhesion molecules that maintain synapse function for proper neural c

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Hoffmann, Hanne M. "Evidence of histamine H3 receptor crosstalk with dopamine D1 receptors and group 1 metabotropic glutamate receptors in the brain : possible link with cocaine addiction-like behavior in rodents." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20139.

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La modification de l'activité neuronale peut engendrer des altérations dans des circuits neuronaux. L'activation des récepteurs couplés aux protéines G (RCPG) peux participer à des mécanismes à la base du développement de maladies comme l'addiction à la cocaïne. La consommation de cocaïne conduit à une augmentation de neurotransmetteurs tels que la dopamine, l'histamine et le glutamate qui activent des RCPG dans le cerveau. La signalisation des RCPG peut se faire au travers de monomères, d'homo- ou d'hétéromères de RCPG ainsi que par des interactions protéine - protéine, permettant entre autre

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Vitet, Hélène. "Conséquences de la régulation du transport axonal par la huntingtine sur l'homéostasie de réseaux neuronaux et sur le comportement, en conditions saine et pathologique Traffic signaling: new functions of huntingtin and axonal transport in neurological disease Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin." Thesis, Université Grenoble Alpes, 2020. http://www.theses.fr/2020GRALV038.

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Les circuits neuronaux régissent les comportements tels que la coordination motrice ou la mémoire et l’apprentissage. Au sein d’un réseau, les neurones communiquent par des processus moléculaires et cellulaires finement réglés à la synapse. Un des mécanismes régulant l’homéostasie synaptique, le transport de vésicules dans les neurones, est dérégulé dans les maladies neurologiques telles que le syndrome de Rett, la maladie d’Alzheimer et la maladie d’Huntington. Ainsi, investiguer la régulation du transport de vésicules dans les neurites dans un contexte physiologique est important pour compre

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Cole, Christina Jean. "A Role for MEF2 in the Synaptic Plasticity Mechanisms Underlying Long-term Memory Formation." Thesis, 2011. http://hdl.handle.net/1807/31686.

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The synaptic remodeling of neural circuits is thought to underly memory formation. Both long-term memory formation and remote memory formation are thought to involve a process restructuring of synapses in specific areas of the brain. The transcription factor myocyte enhancer factor 2 (MEF2) has been shown to restrict spine growth in both in vivo and in vitro. It has been suggested that MEF2 is a critical molecule involved in memory formation, however, MEF2‘s role in adult memory formation it is largely unexplored. Thus, we have sought to characterize MEF2’s involvement in the formation of

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Martin, Erin. "The behaviour of neurologic water during axonal and synaptic neurotransmission: An in silico study." 2011. http://hdl.handle.net/10222/14091.

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Water is known to take on highly organized structures to influence the reactivity of chemical and biological systems; despite this, water is often only implicitly or approximately included in theoretical studies of biochemical systems, if not omitted entirely. Many of the current models for biological processes predate an understanding of the complex behaviour of water, yet these models have not been updated. This thesis presents an exploration of how a better of water might affect the models used to describe neurotransmission. Two classes of systems are investigated, representing the two main

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Pinar, Cabeza de Vaca Cristina. "Effects of mild traumatic brain injury on hippocampal synaptic plasticity and behaviour in juvenile rats." Thesis, 2019. http://hdl.handle.net/1828/11359.

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Traumatic Brain Injury (TBI) is a global health problem and concussion, or mild TBI (mTBI), accounts for up to 75% of all brain injuries occurring annually in the US. There is also growing awareness that repeated mild traumatic brain injury (r-mTBI) can result in cumulative neuropathology and learning and memory deficits, however there is a paucity of preclinical data as to the extent these deficits manifest. R-mTBI in juvenile populations is of special interest as not only is this a high risk group, but this is also a time period when the human brain continues to mature. The hippocampus is a

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DEBACKER, JULIAN. "Resilient GluN2B-containing NMDARs contribute to dysfunctional synaptic plasticity associated with chronic cocaine intake." Thesis, 2012. http://hdl.handle.net/1974/7321.

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Learning and memory mechanisms that are normally related to natural rewards, such as long-term potentiation (LTP) and depression (LTD), may be usurped by the voluntary intake of drugs of abuse. The maladaptive behaviour that characterizes addiction is thought to arise from persistent changes in excitatory synaptic function in brain reward circuits. The oval region of the dorsal bed nucleus of the stria terminalis (ovBST) is one such region susceptible to drug-induced synaptic remodeling and is implicated in drug-driven behaviors, reinforcement and stress-induced relapse to drug-seeking. Using

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Huang, Wayne. "PAKs 1 & 3 Control Postnatal Brain Development and Cognitive Behaviour through Regulation of Axonal and Dendritic Arborizations." Thesis, 2012. http://hdl.handle.net/1807/33708.

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The molecular mechanisms that coordinate postnatal brain enlargement, synaptic properties and cognition remain an enigma. This study demonstrates that neuronal complexity controlled by p21-activated kinases (PAKs) is a key determinant for postnatal brain enlargement and synaptic properties. Double knockout (DK) mice lacking both PAK1 and PAK3 were severely impaired in postnatal brain growth, resulting in a dramatic reduction in brain volume at maturity. Remarkably, the reduced brain was accompanied by minimal changes in total cell count, due to a significant increase in cell density. However,

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Jung, Pei-Yu, and 鐘珮瑜. "Resistive Switching Behavior and Synaptic Properties in TaOx-based RRAM Device." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/y4gba7.

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碩士<br>國立交通大學<br>電子研究所<br>107<br>Resistive random access memory (RRAM) is one of the most promising nonvolatile memory due to its low power consumption, high operation speed, and compatible with the conventional CMOS process. Most importantly, the synaptic plasticity of RRAM was explored for potential use as an electronic synapse for neuromorphic computing application. In this thesis, we demonstrated a novel approach to optimize conductance tuning linearity and switching stability in TaOx based RRAM device. Firstly, we got the analog resistive switching behavior instead of binary switching by u

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Wei-JuChen and 陳威儒. "Analog Switching Behavior of TaOx-based Bilayer Dielectrics for Synaptic Device Application." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/9vpbm5.

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Monteiro, Patrícia Isabel Rodrigues. "Synaptic and circuitry mechanisms of basal ganglia dysfunction in compulsive and repetitive behavior." Doctoral thesis, 2015. http://hdl.handle.net/10316/28690.

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Tese de doutoramento em Biociências, no ramo de Neurociências, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>As doenças neuropsiquiátricas abrangem um largo espectro de distúrbios comportamentais, incluindo auto-flagelação, défices cognitivos, problemas de interacção social e emocional, entre outros. Dada a ausência de biomarcadores concretos e a sobreposição de sintomas comportamentais, o diagnóstico das doenças neuropsiquiátricas é por vezes efectuado por exclusão relativamente a outras causas subjacentes. Estudos genómico

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Shukla, Avani. "Cocaine-induced synaptic plasticity in the nucleus accumbens and drug-associated behavior - An unexpected dissociation." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-8757-0.

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Ting-RueiLin and 林廷叡. "Photoresponse behavior of zinc tin oxide thin film transistors and its application to synaptic device." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/8xw5rn.

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Vuong, Billy. "Gestational Diabetes Mellitus Induces Neuroinflammation, Synaptic Reduction, Behavioural Changes, and Impaired Memory in the Offspring." 2016. http://hdl.handle.net/1993/31802.

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Gestational diabetes mellitus (GDM) is a common complication of pregnancy and population health studies have linked it to impaired cognitive performance in the offspring. GDM triggers inflammatory responses, which can critically affect development of neuronal circuitry. We hypothesized that GDM promotes inflammatory responses in the fetus that can disturb fine-tuning of neuronal networks during early development, resulting in lifelong impaired cognitive functions. The cognitive performance of 15 week old offspring exposed to diet induced GDM were assessed. The brain tissue of the 15 week old

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Fernandes, Ana Cristina Coelho. "Drosophila models of neuromuscular disorders: From morphology to behavior." Master's thesis, 2018. http://hdl.handle.net/10362/54384.

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RESUMO: As doenças neurodegenerativas, que podem originar ataxia ou demência, são doenças incuráveis e debilitantes que têm como consequência a degeneração progressiva seguida de morte neuronal. O mecanismo que provoca a neurodegeneração não é totalmente conhecido, sabendo-se apenas que está associado a múltiplas vias e contribuições genéticas. Dada a complexidade e variedade de mecanismos patológicos, um tratamento eficaz para este tipo de distúrbio é difícil de alcançar. Uma forma de contornar esta dificuldade, é através da promoção da complexidade neuronal de células ainda funcionais como m

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Wu, Han-Fang, and 吳函芳. "Investigation of Amygdala Mediated Synaptic Function and Behaviors in Autism Spectrum Disorder-like Animal Model." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/yvede5.

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博士<br>國立陽明大學<br>生理學研究所<br>106<br>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social communication, restricted and repetitive interests/behaviors and abnormal emotional responses. The amygdala and prefrontal cortex (PFC) have been reported in regulating socio-emotional behaviors and cognitive function in individual with ASD. The autism-like phenotypes of valproic acid (VPA)-exposed offspring have been observed the imbalances between synaptic excitation and inhibition (E/I) neurotransmission leading to abnormal synaptic flexibility associated with N-

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Lin, Chia-Wen, and 林佳玟. "Sarm1, a molecule involved in innate immunity, regulates synaptic plasticity and autistic-like behaviors in mice." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/30747293737626781239.

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博士<br>國防醫學院<br>生命科學研究所<br>101<br>Neurodevelopmental disorders, including autism, schizophrenia and attention deficiency and hyperactivity disorder, are complex neuropsychiatric diseases. Both environmental factors and genetic deficits contribute to the pathogenesis of neurodevelopmental disorders. The most well-known environmental factor is prenatal immune challenge caused by infection. Robust cytokine production induced by inflammatory response is believe to affect neural development and leads to several psychiatric disorders. However, the detail mechanism is not clear yet. In this study, I f

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Sertel, Sinem Meleknur. "Time- and gender- dependent differences in neuronal behaviors in culture." Thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-13BF-F.

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Voller, Jaroslav. "Role hmatových vousů v kompenzaci zrakového deficitu a vliv neurodegenerativního postižení na krosmodální plasticitu u myšího modelu retinální a olivocerebelární degenerace." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-333741.

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Sensory deprivation in one modality can enhance the development of the remaining modalities via mechanisms of synaptic plasticity. Mice of C3H strain suffers from RD1 retinal degeneration that leads to visual impairment at weaning age. Independently on the retinal degeneration there is also present olivocerebellar degeneration caused by Lurcher mutation. This neurodegenerative disorder causes motor deficits, increased CNS excitability as well as changes in synaptic plasticity. The aim of this study was to evaluate a role of whiskers in compensation of the visual deficit and to assess the influ

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Nuwal, Nidhi. "Optogenetic investigation of nervous system functions using walking behavior and genome wide transcript analysis of Synapsin and Sap47 mutants of Drosophila." Doctoral thesis, 2010. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-51694.

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PART I Animals need to constantly evaluate their external environment in order to survive. In some cases the internal state of the animal changes to cope with it’s surrounding. In our study we wanted to investigate the role of amines in modulating internal states of Drosophila. We have designed a behavioral paradigm where the flies are fixed in space but can walk on a small styrofoam ball suspended by a gentle stream of air. The walking activity of flies was used as behavioral readout. PART I Animals need to constantly evaluate their external environment in order to survive. In some cases the

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Nuwal, Nidhi [Verfasser]. "Optogenetic investigation of nervous system functions using walking behavior and genome wide transcript analysis of synapsin and Sap47 mutants of Drosophila / vorgelegt von Nidhi Nuwal." 2010. http://d-nb.info/1007658894/34.

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Silva, Ana Rita Vieira Trindade da. "Identifying the mechanistic role of TAU proteins in brain´s risk and protective factors." Master's thesis, 2013. http://hdl.handle.net/1822/45461.

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Dissertação de Mestrado em Ciências da Saúde<br>Tau is a cytoskeletal protein which binds to microtubules and regulates their assembly and stabilization. Interestingly, recent evidence suggests novel roles of Tau in synaptic structure and function. On the other hand, Tau hyperphosphorylation and subsequent malfunction is suggested to be a key parameter of synaptic dysfunction and atrophy and memory loss that characterized Alzheimer´s disease. Indeed, cumulative evidence from experimental studies demonstrated that absence of Tau blocked Aβ detrimental properties on synaptic dysfunction and loss

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Lin, Chih-Peng, and 林至芃. "Long term effects of neonatal inflammatory pain on the nocifensive behaviors and trans-synaptical transmission in the adult rat spinal cord dorsal horn neurons." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/78766242992586438823.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>93<br>Advances in medical technology have significantly improved survival among medically compromised premature babies. However, poorly managed pain during this period will result in long-term physiologic and behavioral consequences. Animal studies reveal that neonatal peripheral inflammatory pain results in long-standing changes on the development of nociceptive neuronal circuitry. Morphologically, fine primary afferent fibers termination area in spinal cord dorsal horn expands longitudinally and sprouts into deeper lamina. Electrophysiologic study shows increase in

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