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Artykuły w czasopismach na temat „Synergistic Botanicals”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Maradi, Ramesh M., S. B. Jagginavar, Keerthana A, and Gangadhara Doggalli. "Synergistic Strategies for the Management of Thrips, Scirtothrips dorsalis in Pomegranate Ecosystem." Journal of Experimental Agriculture International 46, no. 9 (2024): 354–61. http://dx.doi.org/10.9734/jeai/2024/v46i92832.

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Thrips management in pomegranate cultivation is critical due to the significant damage these pests can inflict on fruit yield and quality. The study was carried out in farmers field at Managuli, Vijayapura, College of Agriculture, Vijayapura, Karnataka during 2020-2021. The integrated management of thrips, Scirtothrips dorsalis in pomegranate revealed that the in-situ vermiculture technique along with chemicals (86.93 per cent) and botanicals (59.40 %) found to be more effective in controlling thrips than in-situ vermiculture technique alone (39.22 %). It also revealed that in-situ vermicultur

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Wang, Chong-Zhi, Tyler Calway, and Chun-Su Yuan. "Herbal Medicines as Adjuvants for Cancer Therapeutics." American Journal of Chinese Medicine 40, no. 04 (2012): 657–69. http://dx.doi.org/10.1142/s0192415x12500498.

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In the United States, many patients, including cancer patients, concurrently take prescription drugs and herbal supplements. Co-administration of prescription medicines and herbal supplements may have negative outcomes via pharmacodynamic and pharmacokinetic herb-drug interactions. However, multiple constituents in botanicals may also yield beneficial pharmacological activities. Botanicals could possess effective anticancer compounds that may be used as adjuvants to existing chemotherapy to improve efficacy and/or reduce drug-induced toxicity. Herbal medicines, such as ginseng, potentiated the

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Sontakke, Pritin P., G. T. Behere, D. M. Firake, and D. P. Thubru. "EVALUATION OF TOXICITY AND COTOXICITY OF BIOPESTICIDES AGAINSTDIAMONDBACK MOTH, PLUTELLA XYLOSTELLA (L.)." Journal of Biopesticides 07, no. 01 (2014): 90–97. http://dx.doi.org/10.57182/jbiopestic.7.1.90-97.

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ABSTRACT In India, the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is an important pest of cruciferous vegetables and causes severe economic losses. This pest has ability to evolveresistance in laboratory and field to almost all groups of synthetic insecticides. Despite of these, management with synthetic insecticides has been considered to be the easy and favorable option byfarmers in India which indeed increase the cost of cultivation and obviously reduction in the actual net profit. The use of microbial and botanicals pesticides are also available in the market an

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SINGH, S., and P. P. DAVE AND H. CHOUDHARY. "Botanical Compositions for the Management of Sucking and Lepidopteran Pests of Groundnut (Arachis hypogaea L.) Under Field Conditions." BIOPESTICIDES INTERNATIONAL 20, no. 01 (2024): 65. http://dx.doi.org/10.59467/bi.2024.20.65.

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The efficacy of two botanical formulations, an oil-based (OF) and aqueous (AqF), was determined against sucking and lepidopteran pests of groundnut. The experiment was laid out in a randomized block design with seven treatments and three replicates for each. The treatments were botanical formulations at 10 and 20 mL/L concentrations, along with a standard chemical (Chlorpyriphos 20EC at the rate of 2.5 mL/L) and a botanical (neem oil at 3 mL/L) and a negative control. The results revealed that the whitefly population reduction was 92.8% in chlorpyriphos treatment, followed by 80.0% in AqF at 2

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Zuo, Hua-Li, Hsi-Yuan Huang, Yang-Chi-Dung Lin, et al. "Enzyme Activity of Natural Products on Cytochrome P450." Molecules 27, no. 2 (2022): 515. http://dx.doi.org/10.3390/molecules27020515.

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Drug-metabolizing enzymes, particularly the cytochrome P450 (CYP450) monooxygenases, play a pivotal role in pharmacokinetics. CYP450 enzymes can be affected by various xenobiotic substrates, which will eventually be responsible for most metabolism-based herb–herb or herb–drug interactions, usually involving competition with another drug for the same enzyme binding site. Compounds from herbal or natural products are involved in many scenarios in the context of such interactions. These interactions are decisive both in drug discovery regarding the synergistic effects, and drug application regard

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Anuj, Vashishtha, and Kumari Neerja. "Development of a Multifunctional Herbal Gel for Chronic Acne Using Turmeric Oil and Synergistic Botanicals." Journal of Advanced Research and Reviews in Virology & Microbiology 2, no. 1 (2025): 15–28. https://doi.org/10.5281/zenodo.15461147.

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<em>Chronic acne is a long-lasting condition characterized by ongoing inflammation and microbial imbalance, necessitating the development of new treatment options that are both effective and gentle on the skin. This research investigates the formulation and evaluation of a natural topical gel designed to tackle these challenges. The gel combines 3% turmeric oil, 2% EGCG green tea extract, 1.5% sea buckthorn oil, 5% witch hazel extract, 1% vitamin E oil, and a guar gum-based hydrogel. These plant-derived components were selected for their synergistic effects: curcuminoids in turmeric oil offer

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Babarinde, Samuel, Kehinde Kemabonta, Ifeoluwa Aderanti, Funmilayo Kolawole, and Adetayo Adeleye. "Synergistic effect of spinosad with selected botanical powders as biorational insecticides against adults of Tribolium castaneum Herbst, 1797 (Coleoptera: Tenebrionidae)." Journal of Agricultural Sciences, Belgrade 63, no. 1 (2018): 39–51. http://dx.doi.org/10.2298/jas1801039b.

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The synergistic effect of spinosad with three botanical (Aframomum melegueta, Eugenia aromatica and Piper guineense) powders as biorational insecticides against Tribolium castaneum Herbst (Coleoptera: Tenebrionidae) infesting melon (Citrullus lanatus) seeds was investigated. Treatments included sole application of each botanical powder (50 g/kg of melon seed), sole application of spinosad (SASp) (1.0g/kg), mixture of spinosad (0.5 g/kg) + botanical powders (25 g/kg) and an untreated control. Data were collected on tenebronid mortality rate (%) (PM) and melon seed weight loss rate in % (PWL). P

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Odewole, Adeola Foluke, Fatai Olaitan Alao, Adedayo Akeem Agboola, and Bolawaye Folakemi Adedapo. "Comparative Efficacy of Plant Extracts with Synthetic against Insect Pests of Okra (Abelmoschus esculentus L. Monech)." International Letters of Natural Sciences 19 (July 2014): 52–58. http://dx.doi.org/10.18052/www.scipress.com/ilns.19.52.

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A field study was carried out during the two cropping seasons of okra to investigate the efficacy of plant extracts and synthetic insecticides applied singly and synergistic effect of botanicals with the synthetic insecticide on some insect pests of okra. Plots were arranged in a Randomized Complete Block Design (RCBD), with three replications. Three insect pests of okra (Podagrica uniformis, Podagrica sjostedti and Zenocerous variegatus) were observed on the field. Cypermethrin applied singly and Cypermethrin combined with plant extracts effectively controlled observed insect pests, followed

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Odewole, Adeola Foluke, F. A. Olaitan, Adedayo Akeem Agboola, and Bolawaye Folakemi Adedapo. "Comparative Efficacy of Plant Extracts with Synthetic against Insect Pests of Okra (<i>Abelmoschus esculentus</i> L. Monech)." International Letters of Natural Sciences 19 (July 16, 2014): 52–58. http://dx.doi.org/10.56431/p-6fr3q3.

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A field study was carried out during the two cropping seasons of okra to investigate the efficacy of plant extracts and synthetic insecticides applied singly and synergistic effect of botanicals with the synthetic insecticide on some insect pests of okra. Plots were arranged in a Randomized Complete Block Design (RCBD), with three replications. Three insect pests of okra (Podagrica uniformis, Podagrica sjostedti and Zenocerous variegatus) were observed on the field. Cypermethrin applied singly and Cypermethrin combined with plant extracts effectively controlled observed insect pests, followed

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Sobowale, A. A., and M. I. Adeyanju. "Mycotoxic potentials of Azadirachta indica Adr. Juss. and Aloe vera (L.) N. Burman extracts against Fungi associated with Rotting Capsicum annuum L. (Chilli Pepper)." Advances in Multidisciplinary and scientific Research Journal Publication 29 (December 15, 2021): 45–74. http://dx.doi.org/10.22624/aims/abmic2021-v2-p5.

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The mycotoxic potentials of Azadirachta indica Adr. Juss. and Aloe vera (L.) N. Burman extracts was tested against rot of Capsicum annuum L. (Chilli pepper). The fungi were isolated from rotting pepper fruits by placing them aseptically on acidified potato dextrose agar. Pure cultures were obtained by sub culturing onto fresh acidified PDA and later stored at room temperature. Aqueous and methanol extracts of Azadirachta indica and Aloe. vera were obtained using standard measures. The isolated fungi were identified and cultured on acidified potato dextrose agar impregnated aqueous and methanol

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Parihar, Aniket, and Sonali Verma. "Formulation of a Novel Emulgel for Wound Healing: A Synergistic Blend of Three Unique Botanical Extracts." PEXACY International Journal of Pharmaceutical Science 2, no. 12 (2023): 153–66. https://doi.org/10.5281/zenodo.10299164.

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<strong>Abstract: </strong>This study aimed to develop and evaluate a novel Emulgel formulation for wound healing, incorporating the extracts of Comfrey (<i>Symphytum officinale</i>), Yarrow (<i>Achillea millefolium</i>), and Myrrh (<i>Commiphora myrrha</i>). Phytochemical analysis of the extracts confirmed the presence of various bioactive compounds. The formulations were characterized for pH, viscosity, spreadability, and in vitro drug release, demonstrating properties conducive to effective wound healing applications. An in vitro wound healing assay using Human Fibroblast Cells indicat

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Ashish, Sharma, and Upadhyay Amit. "Formulation of an Advanced Herbal Shampoo: Harnessing Uncommon Botanicals for Advanced Hair Care." PEXACY International Journal of Pharmaceutical Science 2, no. 12 (2023): 129–40. https://doi.org/10.5281/zenodo.10275785.

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<strong>Abstract: </strong><strong>Objective:</strong> This study aimed to develop and evaluate a novel herbal shampoo incorporating a blend of Sapindus Mukorossi, Eclipta Alba, Nardostachys Jatamansi, Hedychium Spicatum, and Azadirachta Indica, known for their beneficial properties in hair care.<strong>Methods: </strong>The shampoo formulations were prepared and characterized for phytochemical content, pH, viscosity, spreadability, and in vitro drug release. Phytochemical analysis was conducted to identify the presence of key bioactive compounds, while TLC provided qualitative insights i

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Srushti, Phadtare* Sakshi Yadav Vansh Wagh Pradyna Yadav Shreya Yadav Sanket Wankhede. "Herbal Depigmentation Cream." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 305–14. https://doi.org/10.5281/zenodo.15333304.

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Skin pigmentation disorders like hyperpigmentation, melasma, dark spots, and post-inflammatory pigmentation affect millions worldwide, often triggered by UV exposure, hormonal changes, inflammation, and aging. While conventional depigmenting agents like hydroquinone and kojic acid are effective, they can cause skin irritation and sensitivity, leading to a demand for safer alternatives. Herbal ingredients have gained attention for their natural skin-brightening and healing properties. Botanicals such as turmeric, aloe vera, licorice, alum, honey, vitamin E, glycerin, and rose water show po

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V., Amrutha G., Aruna V., and Gayathri Rajagopal. "Psorolin B: a formulation with synchronized, synergistic scooping of botanicals and associated exodus therapeutic benefit to psoriasis." International Journal of Research in Dermatology 8, no. 1 (2021): 85. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20214918.

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<p><strong>Background:</strong> Psoriasis is an auto-inflammatory disease condition, with the clinical symptoms of scaling, inflammation and itching. This condition is triggered by external and internal factors such as environment, seasons and free radicles etc. Psorolin B is a proprietary Siddha Medicine indicated for the reduction in the psoriatic symptoms and also for inhibiting the various triggers of psoriasis</p><p><strong>Methods:</strong> In the present paper, the formulation is evaluated for its anti-oxidant effect, anti-glycation effect, enzy

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Kiran, R. Shireesh, Bandi Shivaji, Chakali Shivaleela, and Kilaru Eshitha. "Dry Shampoo: A Quick Fix for Fresh Hair." International Journal of Research and Innovation in Applied Science X, no. IV (2025): 1135–47. https://doi.org/10.51584/ijrias.2025.10040092.

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The growing demand for natural hair care products has led to the formulation of dry shampoos incorporating traditional botanicals known for their cleansing, nourishing, and therapeutic properties. This review explores the synergistic benefits of shikakai (Acacia concinna), amla (Emblica officinalis), reetha (Sapindus mukorossi), and turmeric (Curcuma longa) in dry shampoo products. Shikakai, with its mild saponin content, serves as a gentle cleanser that removes excess oil and dirt without stripping natural moisture from the hair. Reetha, rich in saponins, provides effective foaming action, ai

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Zhao, Yi, J. Jason Collier, E.-Chu Huang, and Jay Whelan. "Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling." Functional Foods in Health and Disease 4, no. 7 (2014): 312. http://dx.doi.org/10.31989/ffhd.v4i7.1.

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Background: Pre-clinical studies using bioactive compounds from botanicals appear to offer some protection against cancer. Research using single bioactives contributes greatly to our understanding of their mechanism of action, but in vitro studies demand concentrations that are higher than achievable in humans (µM). However, maintaining these bioactives in the presence of other compounds originally derived from the food or extract of origin may synergistically lower the bioactive dose so translatability becomes feasible. The objective of this study was to determine if bio-efficacy of phytonutr

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Ahmed, Kanwer Shahzad, Atif Idrees, Muhammad Zeeshan Majeed, et al. "Synergized Toxicity of Promising Plant Extracts and Synthetic Chemicals against Fall Armyworm Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae) in Pakistan." Agronomy 12, no. 6 (2022): 1289. http://dx.doi.org/10.3390/agronomy12061289.

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Fall armyworm, Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae), is a destructive pest of a wide array of agricultural and horticultural crops worldwide. This in vitro research assessed the combined effect of methanolic extracts of indigenous flora of Soone Valley (Khushab, Pakistan) and nine commonly used synthetic insecticides against 3rd instar larvae of S. frugiperda using the leaf-dip bioassay method. Toxicity bioassays with twelve plant extracts revealed that the extracts of Withania somnifera (L.) Dunal, Sophora mollis (Royle) Baker and Rhazya stricta Decne. were the most effec

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Sulaiman, Bello, Tersoo Poul Terna, and Onwuanuo Edith Kelechi. "Botanical Control of Cowpea Weevil (Callosobruchus maculatus) in Stored Cowpea Using Ocimum gratissimum and Allium sativum Powders in Lafia, Nasarawa State." UMYU Scientifica 4, no. 2 (2025): 1–6. https://doi.org/10.56919/usci.2542.001.

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Study’s Excerpt:• This work offers an affordable, eco-friendly method for controlling Callosobruchus maculatus in stored cowpeas.• It deepens understanding of O. gratissimum and A. sativum powders, alone and in a synergistic mix.• The findings offer a viable post-harvest option for farmers using local botanicals in Lafia, Nigeria.Full Abstract:An infestation of storage cowpeas caused by Callosobruchus maculatus poses a significant risk, which can lead to food shortages and economic losses especially where cowpeas are a main crop. This study investigated the insecticidal potential of Allium sat

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Garvit, Singh* Deepak Singh Pankaj Vyas. "Harnessing Nature's Potential: Innovating Antibacterial Cream Through Garlic And Clove Extracts." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1811–16. https://doi.org/10.5281/zenodo.14014244.

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The onset of the antibiotics period was characterised by the clinical implementation of penicillin, the inaugural antibiotic, unearthed in 1928 by Alexander Fleming in the green mould Penicillium notatum. Garlic and clove have long been used as traditional treatments for different diseases, including infections. Their antibacterial qualities have been attributed to their sulfur-containing components, such as allicin and ajoene in garlic, and eugenol and isoeugenol in clove. In this study, we wanted to produce a novel antibacterial cream leveraging the synergistic properties of garlic and clove

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Sharma, Priyanka, Tadanobu Shimura, Jasjit K. Banwait та Ajay Goel. "Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer". Carcinogenesis 41, № 10 (2020): 1385–94. http://dx.doi.org/10.1093/carcin/bgaa090.

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Abstract Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU)-based chemotherapeutic regimens, attributing the increased overall morbidity and mortality. In view of the growing evidence that active principles in various naturally occurring botanicals can facilitate chemosensitization in cancer cells, herein, we undertook a comprehensive effort in interrogating the activity of one such botanical—andrographis—by analyzing its activity in CRC cell lines [both sensitive and 5FU

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Prakash, Anand, Jagadiswari Rao, and V. Nandagopal. "FUTURE OF BOTANICAL PESTICIDES IN RICE, WHEAT, PULSES AND VEGETABLES PEST MANAGEMENT." Journal of Biopesticides 01, no. 02 (2008): 154–69. http://dx.doi.org/10.57182/jbiopestic.1.2.154-169.

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ABSTRACT Use of botanicals is now emerging as one of the important means to be used in protection of crop produce and the environment from pesticidal pollution, which is a global problem. In this chapter, the authors focus on the future of botanical pesticides with special references to agriculture. Two main aspects of botanical pesticides , one search and exploitation of new botanicals as pesticides including isolation, identification and evaluation of the active components and another use of botanicals in agriculture in different forms like direct spray applications of the various plant mate

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Singh, Sneh, and Shubhra Saraswat. "Botanical Solutions: Exploring Herbal Therapies for Thyroid Disorders." International Journal of Health Sciences and Research 14, no. 12 (2024): 65–72. https://doi.org/10.52403/ijhsr.20241207.

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Thyroid disorders, encompassing conditions such as hypothyroidism, hyperthyroidism, and thyroid nodules, pose significant challenges in healthcare due to their prevalence and diverse clinical manifestations. While conventional medical treatments play a crucial role, increasing attention has been directed towards herbal interventions as adjunctive or alternative therapies. This review systematically examines the efficacy and underlying mechanisms of various herbs commonly used in the management of thyroid disorders. Through comprehensive literature analysis, we highlight the pharmacological pro

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Yimam, Mesfin, Teresa Horm, Laura Wright, et al. "Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised ofMorus alba,Scutellaria baicalensis, andAcacia catechu." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/7059068.

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Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition fromMorus alba,Scutellaria baicalensis, andAcacia catechuin maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA disease model. Study lasted for 6 weeks. 59.6%, 64.6%, 70.7%, 69

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XU, CAIMING, SILEI SUI, Keisuke Okuno, Silvia Pascual-Sabater, Cristina Fillat, and Ajay Goel. "Abstract 3821: Berberine and emodin synergistically suppress the EGFR signaling cascade by targeting LAMB3 in pancreatic ductal adenocarcinoma." Cancer Research 83, no. 7_Supplement (2023): 3821. http://dx.doi.org/10.1158/1538-7445.am2023-3821.

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Abstract Background: Pancreatic cancer is one of the most devastating malignancies due to the development of intrinsic chemoresistance following chemotherapy. Extracellular matrix (ECM) proteins are intimately linked to cellular proliferation, invasion, and acquisition of chemoresistance in PDAC cells, making them promising therapeutic targets in this malignancy. Naturally occurring dietary botanicals, including berberine (BER) and emodin (EMO), have been shown to suppress ECM as one of the mechanism(s) for their anti-tumorigenic activity, along with their time-tested safety and cost-effective

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Yimam, Mesfin, Ping Jiao, Breanna Moore, et al. "Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised ofSchisandra chinensis,Artemisia capillaris, andAloe barbadensis." Journal of Nutrition and Metabolism 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/3530971.

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Some botanicals have been reported to possess antioxidative activities acting as scavengers of free radicals rendering their usage in herbal medicine. Here we describe the potential use of “SAL,” a standardized blend comprised of three extracts fromSchisandra chinensis,Artemisia capillaris, andAloe barbadensis, in mitigating chemically induced acute liver toxicities. Acetaminophen and carbon tetrachloride induced acute liver toxicity models in mice were utilized. Hepatic functional tests from serum collected at T24 and hepatic glutathione and superoxide dismutases from liver homogenates were e

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Kamthe, Mr Prathamesh. "A Review: Preparation and Evaluation of Herbal Foot Cream by using Tridax Procumbens Extract." International Journal for Research in Applied Science and Engineering Technology 13, no. 4 (2025): 5369–74. https://doi.org/10.22214/ijraset.2025.69604.

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Abstract: The growing demand for natural and sustainable skincare solutions has led to increased interest in herbal formulations for foot care. Foot creams enriched with plant extracts offer therapeutic benefits while minimizing the side effects associated with synthetic ingredients. Tridax procumbens, a medicinal plant with well-documented antimicrobial, antiinflammatory, and wound-healing properties, presents a promising candidate for developing an effective herbal foot cream. This review explores the preparation methods, formulation strategies, and pharmacological evaluation of Tridax procu

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Maloh, Jessica, Mincy Chakkalakal, Fatima Sulaiman, Waqas Burney, Cindy J. Chambers, and Raja K. Sivamani. "Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study." Journal of Clinical Medicine 11, no. 22 (2022): 6690. http://dx.doi.org/10.3390/jcm11226690.

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External and internal stressors have been found to adversely affect skin health and overall wellness. There is growing interest in the use of anti-inflammatory and antioxidant plant-derived ingredients, such as ashwagandha, saffron, l-theanine, and tocopherol, to mitigate the impact of these stressors. In this study, we evaluate the effectiveness of oral and topical products (InnerCalm and SuperCalm, respectively) that contain naturally derived ingredients on skin redness, skin pigmentation, sleep, and mood in healthy females with Fitzpatrick skin type 1–4 and self-perceived sensitive skin. Su

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C. O, Cookey, Dialoke S.A, Keyagha E.R, Bosah B.O, and Ogbedeh K.O. "Synergistic Effect of Poultry Manure and Some Botanicals on Cowpea Root-Gall Nematode Infection in a Naturally Infested Soil of Owerri, Imo State, Nigeria." Canadian Journal of Agriculture and Crops 4, no. 1 (2019): 17–25. http://dx.doi.org/10.20448/803.4.1.17.25.

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Younoussa, Lame, Francine Kenmoe, Mallam Kary Oumarou, Aurore Christelle Sengue Batti, Joseph Lebel Tamesse, and Elias Nchiwan Nukenine. "Combined Effect of Methanol Extracts and Essential Oils of Callistemon rigidus (Myrtaceae) and Eucalyptus camaldulensis (Myrtaceae) against Anopheles gambiae Giles larvae (Diptera: Culicidae)." International Journal of Zoology 2020 (April 28, 2020): 1–9. http://dx.doi.org/10.1155/2020/4952041.

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Biopesticides from botanicals are nowadays actively encouraged in the mosquito control program because of their low mammalian toxicity, biodegradability, and target specificity. However, leaf methanolic extracts and essential oils of Callistemon rigidus and Eucalyptus camaldulensis were evaluated individually and in combination on third- and fourth-instar larvae of Anopheles gambiae. The extracts were tested individually and in combination at doses of 125, 250, 500, and 1000 ppm while essential oils were applied at 25, 50, 100, and 200 according to the standard protocol of WHO. The commercial

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Miyazaki, Katsuki, Yuji Morine, Caiming Xu, et al. "Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma." Cells 12, no. 4 (2023): 612. http://dx.doi.org/10.3390/cells12040612.

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Lenvatinib is a multi-kinase inhibitor approved as a first-line treatment for patients with unresectable advanced hepatocellular carcinoma (HCC). However, its response rate is unsatisfactory, primarily due to the acquisition of resistance, which limits its clinical significance for treating patients with HCC. Recent evidence suggests that epidermal growth factor receptor (EGFR) activation can trigger Lenvatinib-resistance; and is considered an important therapeutic target in HCC. Curcumin, one of the most studied naturally occurring botanicals with robust anti-cancer activity, is also reported

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Pratiksha, Gore*1 Pawan Nimbalkar1 Vikas Kakde1 Shivam Patekar1 Rushikesh Veer1 Arti Gadekar1 Gulshan Rathi2 Dr. Rao Javvji3. "Formulation and Characterization of a Polyherbal Nanogel for Acne Management." International Journal of Scientific Research and Technology 2, no. 6 (2025): 87–101. https://doi.org/10.5281/zenodo.15573143.

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Acne vulgaris is a prevalent dermatological disorder primarily affecting adolescents and young adults, often associated with inflammation, microbial colonization, and excess sebum production. Conventional acne therapies, though effective, frequently cause adverse effects such as irritation, dryness, and antibiotic resistance. This study aimed to develop and evaluate a polyherbal nanogel formulation incorporating botanicals known for their anti-inflammatory, antibacterial, and antioxidant properties. The selected herbs—Curcuma longa (turmeric), Azadirachta indica (neem), Melaleuca alterni

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Demgne, Olive Monique F., Francois Damen, Aimé G. Fankam, et al. "Botanicals and phytochemicals from the bark of Hypericum roeperianum (Hypericaceae) had strong antibacterial activity and showed synergistic effects with antibiotics against multidrug-resistant bacteria expressing active efflux pumps." Journal of Ethnopharmacology 277 (September 2021): 114257. http://dx.doi.org/10.1016/j.jep.2021.114257.

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Ramachandran, Cheppail, Ashley Juan, Karl-W. Quirin, et al. "Anticancer and Anti-metastatic Effects of Supercritical Extracts of Hops (Humulus lupulus L.) and Mango ginger (Curcuma amada Roxb.) in Human Glioblastoma." International Journal of Phytomedicine 10, no. 4 (2019): 191. http://dx.doi.org/10.5138/09750185.2285.

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Glioblastoma is one of the most aggressive, lethal and incurable primary brain tumors with a dismal prognosis in humans. Mango ginger (<em>Curcuma amada</em>) and hops <em>(Humulus lupulus</em>) are two botanicals containing phytochemicals with potential anticancer effects. We have investigated the anticancer and antimetastatic properties of supercritical CO<sub>2</sub> extract of mango ginger (CA) and ethanol extract of hops (HL) in the U-87MG human glioblastoma cell line. Both CA and HL individually demonstrate strong cytotoxicity against glioblastoma cell

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Husain, Tasneem. "Nutritional and Health Beneficial Properties of Psoralea corylifolia and Withania somnifera: A Comprehensive Review." SSN Journal of Management & Technology Research Communications 2, no. 1 (2025): 50–55. https://doi.org/10.21786/mntrc/2.1.6.

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Medicinal plants have been a cornerstone of traditional medicine for centuries, offering a wide range of bioactive compounds with therapeutic effects. Among them, Psoralea corylifolia (Babchi) and Withania somnifera (Ashwagandha) are medicinal plants extensively used in traditional and modern medicine for their diverse therapeutic and nutritional benefits. Psoralea corylifolia is a rich source of bioactive compounds such as flavonoids, coumarins, bakuchiol, and essential oils, which contribute to its potent antioxidant, antimicrobial, anti-inflammatory, and hepatoprotective properties. Traditi

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Okuno, Keisuke, Rachana Garg, Masanori Tokunaga, Yusuke Kinugasa, and Ajay Goel. "Abstract 1409: Synergistic antitumorigenic activity of Berberine and oligomeric proanthocyanidins through regulation of PI3-AKt signaling pathway in colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): 1409. http://dx.doi.org/10.1158/1538-7445.am2022-1409.

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Abstract Background: The development of chemo-resistance against conventional chemotherapeutic drugs presents a major clinical challenge in the management of patients with colorectal cancer (CRC). Accumulating body of data in recent years have shown that active principles within various naturally-occurring dietary botanicals not only offer time-tested safety and anti-cancer efficacy, but a combination of certain compounds can overcome the elusive chemotherapeutic resistance in cancer patients. In this regard, data in recent years have shown that berberine (BBR) and oligomeric proanthocyanidins

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Jensen, Gitte S., Dina Cruickshank та Debby E. Hamilton. "Effects of a β-Glucan-Rich Blend of Medicinal Mushrooms and Botanicals on Innate Immune Cell Activation and Function Are Enhanced by a Very Low Dose of Bovine Colostrum Peptides". Molecules 29, № 12 (2024): 2787. http://dx.doi.org/10.3390/molecules29122787.

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Nutraceutical immune support offers potential for designing blends with complementary mechanisms of action for robust support of innate immune alertness. We documented enhanced immune activation when bovine colostrum peptides (BC-Pep) were added to an immune blend (IB) containing β-glucans from yeast, shiitake, maitake, and botanical non-β-glucan polysaccharides. Human peripheral blood mononuclear cells (PBMCs) were cultured with IB, BC-Pep, and IB + BC-Pep for 20 h, whereafter expression of the activation marker CD69 was evaluated on NK cells, NKT cells, and T cells. Cytokine levels were test

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Mahmoud M, F. "Combining the botanical insecticides NSK extract, NeemAzal T 5%, Neemix 4.5% and the entomopathogenic nematode Steinernema feltiae Cross N 33 to control the peach fruit fly, Bactrocera zonata (Saunders)." Plant Protection Science 43, No. 1 (2008): 19–25. http://dx.doi.org/10.17221/2348-pps.

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Botanical insecticides based on azadirachtin and the entomopathogenic nematode Steinernema feltiae were evaluated for their control of the peach fruit fly, <i>Bactrocera zonata</i>. Laboratory bioassays determined the potential of combinations between the biological control agent S. feltiae and the botanical insecticides NSK, NeemAzal T 5%, Neemix 4.5% against 3rd instar larvae of <i>B. zonata</i>. Of 25 treatment combinations between azadirachtin from NSK extract and <i>S. feltiae</i>, 18 gave synergistic responses, 4 were additive, none antagonistic and 3

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J., A. Chavan, and P. Bhawane G. "Effect Of BmNPV Infection and Subsequent Oral Treatment Of Ethanolic Plant Extracts On Cocoon and Post Cocoon Characters In PM and CSR2 B. Mori L." Biolife 4, no. 3 (2022): 475–81. https://doi.org/10.5281/zenodo.7322141.

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<strong>ABSTRACT</strong> In the present investigation BmNPV infection and subsequent oral treatment of ethanolic plant extracts effect was studied. After the inoculation and oral treatment of plant extractives observed the cocoon and post cocoon characters in both PM and CSR2 race. BmNPV inoculated group showed decreased the cocoon weight, shell weight, shell ratio, floss weight, filament length, filament weight and denier in both races. The maximum decrease was observed in CSR2 as compared to PM race. The significantly increased denier was observed in PM race treated with B. spectabilis as c

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Patel, D., T. Turner, E. Nelson, A. Kozin, G. Ruiz, and J. Langland. "TREATMENT OF HERPES VIRUS-ASSOCIATED LESIONS USING A SYNERGISTIC BOTANICAL BLEND." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 122, no. 5 (2016): e163. http://dx.doi.org/10.1016/j.oooo.2016.06.046.

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D’Antraccoli, Marco, Angelino Carta, Giovanni Astuti, et al. "A Comprehensive Approach to Improving Endemic Plant Species Research, Conservation, and Popularization." Journal of Zoological and Botanical Gardens 4, no. 2 (2023): 490–506. http://dx.doi.org/10.3390/jzbg4020036.

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Scientific research is the main driver to push forward and disseminate botanical knowledge. Despite many institutions having this fundamental aim as a core activity, many of them do not have a complete set of facilities, expertise, staff, and resources to cover all the steps involved in the study, management, conservation, and popularization of plant diversity. Accordingly, we propose a workflow formalizing the cooperation between a botanical garden and a botanical research center, focused on the study of plant endemic species. Specifically, the cooperation was implemented between the PLANTSEE

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Wu, Jianhui, Bo Yang, Xiaochen Zhang, Andrew G. S. Cuthbertson, and Shaukat Ali. "Synergistic Interaction between the Entomopathogenic Fungus Akanthomyces attenuatus (Zare & Gams) and the Botanical Insecticide Matrine against Megalurothrips usitatus (Bagrall)." Journal of Fungi 7, no. 7 (2021): 536. http://dx.doi.org/10.3390/jof7070536.

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The excessive use of synthetic chemicals for Megalurothrips usitatus (Bagrall) management has resulted in the development of insecticide resistance as well as adverse effects to the natural ecosystem. This has driven the need to develop alternative pest control strategies. This study reports a synergistic interaction between the entomopathogenic fungus Akanthomyces attenuatus (Zare & Gams) and the botanical insecticide matrine against M. usitatus. The results revealed that the germination rate and colony growth of A. attenuatus were inhibited by higher matrine concentrations. Percentage mo

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HARLIEN, ALLAN T. SHOWLER AND JESSICA L. "Effects of Three Desiccant Dusts and Two Dusts with Botanical Compounds on House Fly (Diptera: Muscidae) Eggs, Larval Development to Pupation and Adult Emergence and Survival." BIOPESTICIDES INTERNATIONAL 20, no. 01 (2024): 73. http://dx.doi.org/10.59467/bi.2024.20.73.

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The house fly, Musca domestica L. (Diptera: Muscidae), is considered to be a nuisance pest and a mechanical carrier of medical and veterinary pathogenic organisms. Because the fly has developed resistance to a variety of commonly used insecticides, novel alternative pest control tactics are being researched. Five desiccant dust-based formulations, silica gel (CimeXa), perlite (Imergard WP), diatomaceous earth (Celite 610, biologically produced in diatoms), silica gel + pyrethrins + piperonyl butoxide (PBO, a synergist) (Drione), and silica gel + thyme oil (EcoVia WD), were evaluated for effect

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Adams, Lynn S., Navindra P. Seeram, Mary L. Hardy, Catherine Carpenter, and David Heber. "Analysis of the Interactions of Botanical Extract Combinations Against the Viability of Prostate Cancer Cell Lines." Evidence-Based Complementary and Alternative Medicine 3, no. 1 (2006): 117–24. http://dx.doi.org/10.1093/ecam/nel001.

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Herbal medicines are often combinations of botanical extracts that are assumed to have additive or synergistic effects. The purpose of this investigation was to compare the effect of individual botanical extracts with combinations of extracts on prostate cell viability. We then modeled the interactions between botanical extracts in combination isobolographically.Scutellaria baicalensis,Rabdosia rubescens,Panax-pseudo ginseng,Dendranthema morifolium,Glycyrrhiza uralensisandSerenoa repenswere collected, taxonomically identified and extracts prepared. Effects of the extracts on cell viability wer

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N, Sakthivel. "EFFICACY OF BOTANICALS AGAINST JASSID EMPOASCA FLAVESCENS F. (HOMOPTERA: CICADELLIDAE) ON MULBERRY AND THEIR BIOSAFETY TO NATURAL ENEMIES." Journal of Biopesticides 5 (April 1, 2012): 246–49. https://doi.org/10.57182/jbiopestic.5.0.246-249.

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Efficacy of somepromising botanicals and the synergists were compared to the commonly usedchemical dichlorvos (76EC) against jassid Empoasca flavescens F.infesting mulberry as well as their biosafety to natural enemies. Among thebotanicals, sole application of neem oil (3%), FORS (2%) and pongamia oil (3%)recorded 48.73, 46.88 and 42.49% reduction in jassid population respectively,whereas the NSKE (5%) exhibited least among all (33.59% at 1 DAS).Thesynergistic effect of neem oil and FORS recorded the best, 72.64% reduction followedby Pongamia oil + FORS (62.81%) and neem oil + pongamia oil (60

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Prayogo, Yusmani. "SINERGISME CENDAWAN ENTOMOPATOGEN Lecanicillium lecanii DENGAN INSEKTISIDA NABATI UNTUK MENINGKATKAN EFIKASI PENGENDALIAN TELUR KEPIK COKLAT Riptortus linearis PADA KEDELAI." Jurnal Hama dan Penyakit Tumbuhan Tropika 11, no. 2 (2011): 166–76. http://dx.doi.org/10.23960/j.hptt.211166-176.

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The aim of the research was to study the synergism of entomopathogenic fungi Lecanicillium lecanii with botanical insecticides to control brown stink bug. The research was carried out in the field experiment station (Kendalpayak) of Indonesian Legume and Tuber Crops Research Institute (ILETRI). Randomized block design (RBD) was used, each treatment was repeated three times. The treatments were three types of botanical insecticides i.e; Aglaia odorata leaf powder (ALP), Annona squamosa seed powder (ASP), and Jatropha curcas seed powder (JSP) of 25, 50 and 75 g/l respectively were combined with

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Marin, Grace, Subramanian Arivoli, and Samuel Tennyson. "Synergistic larvicidal action of Citrus limon (L.) Osbeck (Rutaceae) and Bacillus thuringiensis Berliner 1915 (Bacillaceae) against the dengue vector Aedes aegypti Linnaeus 1762 (Diptera: Culicidae)." GSC Biological and Pharmaceutical Sciences 10, no. 1 (2020): 025–30. https://doi.org/10.5281/zenodo.4280671.

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Botanical and microbial insecticides are promising alternatives to synthetic pesticides for mosquito control because of lower toxicity to non-target organisms and their innate biodegradation ability. The present study was aimed to determine the synergistic larvicidal action of <em>Citrus limon</em> and <em>Bacillus thuringiensis</em> on the dengue vector <em>Aedes aegypti</em>. The crude methanolic leaf extract of <em>Citrus limon</em> and <em>Bacillus thuringiensis</em> were tested separately on the third instar larvae of <em>Aedes aegypti</em

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Hofer, Stefanie, Marcel Jenny, Angela Klein, et al. "Myrobalan Fruit Extracts Modulate Immunobiochemical Pathways In Vitro." Antioxidants 14, no. 3 (2025): 350. https://doi.org/10.3390/antiox14030350.

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Myrobalan fruits are important ingredients of traditional remedies, such as the Ayurvedic formulation Triphala or the Tibetan formulation Bras bu 3. Myrobalan-containing remedies are described to have positive effects on metabolism, the cardiovascular system, and the immune system. The chemical composition of botanical mixtures can be very complex, and it is often impossible to identify individual compounds as specific active ingredients, which suggests a multi-target mode of action. In this in vitro study, the effect of myrobalan extracts in human cell models was investigated to gain more inf

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Prijono, Djoko, Maya Anggraini, Sri Riski Maryani, and Elina Diana Surya. "INSECTICIDAL JOINT ACTION OF TERNARY EXTRACT MIXTURES OF FOUR SPECIES OF TROPICAL PLANTS AGAINST Plutella xylostella AND Crocidolomia pavonana." Jurnal Hama dan Penyakit Tumbuhan Tropika 21, no. 1 (2021): 34–42. http://dx.doi.org/10.23960/j.hptt.12134-42.

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The diamondback moth (DBM), Plutella xylostella, and the cabbage head caterpillar (CHC), Crocidolomia pavonana, were two main pests of cruciferous vegetable crops. Among the viable alternative ingredients that could be utilized to control those two pests were eco-friendly botanical insecticides. This study was conducted to evaluate the joint action of ternary extract mixtures of four tropical plant species, i.e. Piper aduncum (Pa), Piper retrofractum (Pr), Sapindus rarak (Sr), and Tephrosia vogelii (Tv), against DBM and CHC. Results of leaf-residue feeding bioassays showed that based on co-tox

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Jha, Sudhanshu Kumar, Abhishek Gupta, and Vitthal G. Huddar. "Botanical breakthroughs: The growing impact of plant-derived compounds in cancer treatment." Ayush Journal of Integrative Oncology 2, no. 2 (2025): 62–67. https://doi.org/10.4103/ajio.ajio_17_25.

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Abstract Growing evidence of phytochemicals’ diverse biological activity and advantageous safety profiles is fueling a renewed interest in them as anticancer treatments. About half of the anticancer medications that were approved between 1940 and 2014 came from natural sources or their derivatives. With an emphasis on their mechanisms of action, clinical significance, and difficulties in therapeutic translation, this review provides an integrated examination of important plant-derived anticancer drugs, such as vinca alkaloids, taxanes, camptothecin, and podophyllotoxin. These substances target

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Panossian, Alexander, Terry Lemerond, and Thomas Efferth. "State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives." Pharmaceuticals 17, no. 4 (2024): 483. http://dx.doi.org/10.3390/ph17040483.

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Background: Despite some evidence supporting the synergy concept, the commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet to be unambiguously and explicitly studied. Study aim: The study aimed to reveal the molecular interactions in situ of host cells in response to botanical hybrid preparations (BHP) intervention and justify the benefits of implementing BHP in clinical practice. Results: This prospective literature review provides the results of recent clinical and network pharmacology studies

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