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Artykuły w czasopismach na temat „Synthetic Agents”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Brickner, Steven J. "Oxazolidinone Antibacterial Agents." Current Pharmaceutical Design 2, no. 2 (1996): 175–94. http://dx.doi.org/10.2174/1381612802666220921173820.

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The oxazolidinones are a new class of synthetic antibacterial agents. These compounds demonstrate potent in vitro and in vivo activity against important human pathogens, including multiple antibiotic-resistant strains of gram positive organisms including the staphylococci, streptococci, and enterococci. The oxazolidinones have a novel mechanism of action, inhibiting bacterial protein synthesis at a very early step prior to initiation. Literature disclosures have described the inability to detect in vitro bacterial resistance development to the oxazolidinones. Only the (S)-enantiomer is active;

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2

ROBINS, ROLAND K. "Synthetic Antiviral Agents." Chemical & Engineering News 64, no. 4 (1986): 28–40. http://dx.doi.org/10.1021/cen-v064n004.p028.

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Georgiev, Vassil St. "Synthetic immunomodulating agents." Medicinal Research Reviews 10, no. 3 (1990): 371–409. http://dx.doi.org/10.1002/med.2610100305.

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Georgiev, Vassil St. "New synthetic immunomodulating agents." Trends in Pharmacological Sciences 9, no. 12 (1988): 446–51. http://dx.doi.org/10.1016/0165-6147(88)90136-8.

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Nikita Sharma and Mamta Ahuja. "Pyrazoles as anticancer agents: Recent advances." International Journal of Scholarly Research in Chemistry and Pharmacy 3, no. 2 (2023): 013–22. http://dx.doi.org/10.56781/ijsrcp.2023.3.2.0033.

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The present review article offers a detailed account of the design strategies employed for the synthesis of nitrogen-containing anticancer agents. The results of different studies described the N-heterocyclic ring system as a core structure in many synthetic compounds exhibiting a broad range of anticancer activities.

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6

Haridas, V., and Sarala Naik. "Natural macromolecular antifreeze agents to synthetic antifreeze agents." RSC Advances 3, no. 34 (2013): 14199. http://dx.doi.org/10.1039/c3ra00081h.

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Keniche, Assia, Samia Bellifa, Hafida Hassaine, and Joseph Kajima Mulengi. "Development of new antibacterial agents." Medical Technologies Journal 1, no. 2 (2017): 31–32. http://dx.doi.org/10.26415/2572-004x-vol1iss2p31-32.

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Background: Antibiotics, as miraculous drugs, have been used extensively to confront fatal infection, even without prescriptions. However, the inappropriate and disproportionate use of antibiotics have led to the emergence of new drug-resistant bacteria1, which causes a high risk of serious diseases and dramatically aggravates the clinical complications in hospitals. Methods: By using the peptide coupling protocol, a simple straightforward synthesis of functionalized aziridines has been developed. By means of this synthetic strategy from readily available N-phtaloyl acide and 2-methylben

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8

Pinto, Cláudia, Honorina Cidade, Madalena Pinto, and Maria Elizabeth Tiritan. "Chiral Flavonoids as Antitumor Agents." Pharmaceuticals 14, no. 12 (2021): 1267. http://dx.doi.org/10.3390/ph14121267.

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Flavonoids are a group of natural products with a great structural diversity, widely distributed in plant kingdom. They play an important role in plant growth, development and defense against aggressors. Flavonoids show a huge variety of biological activities such as antioxidant, anti-inflammatory, anti-mutagenic, antimicrobial and antitumor, being able to modulate a large diversity of cellular enzymatic activities. Among natural flavonoids, some classes comprise chiral molecules including flavanones, flavan-3-ols, isoflavanones, and rotenoids, which have one or more stereogenic centers. Inter

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9

Myers, Christopher W. "Synthetic Agents as Full-fledged Teammates." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 53, no. 12 (2009): 789–93. http://dx.doi.org/10.1177/154193120905301206.

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An important goal of training systems research is the ability to train teams to criterion while simultaneously minimizing training resources. One promising approach is to develop synthetic agents that act as full-fledged members of a team. Five experts will highlight successes, failures, and continuing challenges associated with the development, validation, and deployment of synthetic agents as full-fledged teammates. The panel will provide an intimate look “under the hood” of synthetic agents, describe what each has found useful for developing a synthetic teammate that “plays well with others

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Tidd, DM. "Synthetic oligonucleotides as therapeutic agents." British Journal of Cancer 63, no. 1 (1991): 6–8. http://dx.doi.org/10.1038/bjc.1991.3.

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Campo, Vanessa Leiria, Marcelo Fiori Marchiori, and Ivone Carvalho. "Insights into Anti-Trypanosomal Agents Based on Synthetic Glycoconjugates." Current Topics in Medicinal Chemistry 18, no. 5 (2018): 382–96. http://dx.doi.org/10.2174/1568026618666180509145305.

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Chagas disease is still a worldwide threat, with estimated 6 to 7 million infected people, mainly in Latin America. Current treatments still rely only on benznidazol and nifurtimox, drugs with poor efficacy in chronic infection phase and recognized toxicity. Thus, there is an urgent need for new therapeutic agents against this disease. In this review we present an updated selection over the last decade of synthetic glycoconjugates as anti-trypanosomal agents, properly addressed as monosaccharideand disaccharide-based agents, and multivalent-based derivatives, disclosing relevant methods for th

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12

Grillo, Alessandro, and Bruno Mattia Bizzarri. "Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents." Catalysts 12, no. 2 (2022): 150. http://dx.doi.org/10.3390/catal12020150.

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The Diels–Alder reaction (DAR) is one of the most effective and reliable strategies for the construction of six-membered carbocyclic and heterocyclic rings, and it is widely used in the synthesis of organic molecules and drugs. Due to the high regio- and stereo-selectivity and its versatility, DARs have represented a powerful tool for organic chemistry for many years. In addition, the asymmetric DAR has become a fundamental synthetic approach in the preparation of optically active six-membered rings and natural compounds. The COVID-19-related pandemic requires continuous research; DAR represen

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13

Moskalik, Mikhail Yu. "Sulfonamides with Heterocyclic Periphery as Antiviral Agents." Molecules 28, no. 1 (2022): 51. http://dx.doi.org/10.3390/molecules28010051.

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Sulfonamides are the basic motifs for a whole generation of drugs from a large group of antibiotics. Currently, research in the field of the new sulfonamide synthesis has received a “second wind”, due to the increase in the synthetic capabilities of organic chemistry and the study of their medical and biological properties of a wide spectrum of biological activity. New reagents and new reactions make it possible to significantly increase the number of compounds with a sulfonamide fragment in combination with other important pharmacophore groups, such as, for example, a wide class of N-containi

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14

Borrego-Muñoz, Paola, Felipe Ospina, and Diego Quiroga. "A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives." Molecules 26, no. 13 (2021): 3997. http://dx.doi.org/10.3390/molecules26133997.

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Vascular wilt caused by F. oxysporum (FOX) is one of the main limitations of producing several agricultural products worldwide, causing economic losses between 40% and 100%. Various methods have been developed to control this phytopathogen, such as the cultural, biological, and chemical controls, the latter being the most widely used in the agricultural sector. The treatment of this fungus through systemic fungicides, although practical, brings problems because the agrochemical agents used have shown mutagenic effects on the fungus, increasing the pathogen’s resistance. The design and the synt

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15

Karypidis, Michail, Evangelos Karanikas, Aikaterini Papadaki, and Eleftherios G. Andriotis. "A Mini-Review of Synthetic Organic and Nanoparticle Antimicrobial Agents for Coatings in Textile Applications." Coatings 13, no. 4 (2023): 693. http://dx.doi.org/10.3390/coatings13040693.

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Many synthetic compounds have been applied to impart antimicrobial properties to fabrics. In this review, the types of bacteria are described. Furthermore, synthetic antimicrobial agents, namely quaternary ammonium compounds (QACs), polyhexamethylene biguanide (PHMB), triclosan, and nitrogen-halamines (N-halamines), are discussed along with their properties, their advantages and disadvantages. Although synthetic antimicrobial agents neutralise microorganisms, some adversely affect the environment, safety and health. These problems led to a novel generation of antimicrobial coating treatments o

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16

Andreotti, Daniele, Stefano Biondi, Daniele Donati, Sergio Lociuro та Gilles Pain. "Synthesis of novel pentacyclic β-lactam antibacterial agents". Canadian Journal of Chemistry 78, № 6 (2000): 772–75. http://dx.doi.org/10.1139/v00-056.

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The search for new antibacterial agents still represents an active area of research. In this paper the synthesis of a new class of β-lactam agents characterized by an interesting antibacterial profile is reported; together with a description of the most significant synthetic aspects encountered during this work.Key words: β-lactams, pentacyclic, O-alkylation, trinem.

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17

Moysa, A. A., and E. F. Kolesanova. "Synthetic peptide vaccines." Biomeditsinskaya Khimiya 57, no. 1 (2011): 14–30. http://dx.doi.org/10.18097/pbmc20115701104.

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This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections. An important role for the development and selection of efficient adjuvants for peptide immunogens is noted. Examples of synthetic peptide vaccine developments against three infectious diseases (malaria, hepatitis C, and foot-and-mouth disease) are given.

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18

Saha, Sudipta, and Priya Dutta. "Journey From Synthetic Cleaning Agents To Green Cleaning Agents- Review." Mapana Journal of Sciences 22, no. 3 (2023): 25–57. https://doi.org/10.12723/mjs.66.2.

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Cleaning reagents are a common substance in every household and are used in everyday lives, especially after the outbreak of COVID-19 around the world. These have been part of the household for hundreds of years. It is essential to remove dirt and germs not only from the clothes but also from the human skin. It is also used to remove stains, dust or unpleasant odours from the body and the clothes. These are available in various forms, such as powders, granules, liquids and sprays. Cleaning reagents are generally manufactured in two ways: naturally and synthetically. The most frequently used sy

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19

Xavier, Nuno M., and Amélia P. Rauter. "Environmentally friendly approaches to the synthesis of new antibiotics from sugars." Pure and Applied Chemistry 84, no. 3 (2012): 803–16. http://dx.doi.org/10.1351/pac-con-11-11-11.

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In light of the biological importance of carbohydrates and their role when present in antibiotic agents, the design and synthesis of carbohydrate-based antibiotics has occupied a prominent place in drug discovery. This review focuses on synthetic carbohydrate antimicrobial agents, giving special emphasis to novel structures easily accessible from readily available carbohydrate precursors.

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20

PELACHAUD, CATHERINE, and ISABELLA POGGI. "Multimodal embodied agents." Knowledge Engineering Review 17, no. 2 (2002): 181–96. http://dx.doi.org/10.1017/s0269888902000218.

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1 Believable interactive embodied agentsAmong the goals of research on autonomous agents one important aim is to build believable interactive embodied agents that are apt to application to friendly interfaces in e-commerce, tourist and service query systems, entertainment (e.g. synthetic actors) and education (pedagogical agents, agents for help and instruction to the hearing impaired).

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21

Sono, Karin, Diane Lye, Christine A. Moore, W. Christopher Boyd, Thomas A. Gorlin, and Jason M. Belitsky. "Melanin-Based Coatings as Lead-Binding Agents." Bioinorganic Chemistry and Applications 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/361803.

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Interactions between metal ions and different forms of melanin play significant roles in melanin biochemistry. The binding properties of natural melanin and related synthetic materials can be exploited for nonbiological applications, potentially including water purification. A method for investigating metal ion-melanin interactions on solid support is described, with lead as the initial target. 2.5 cm discs of the hydrophobic polymer PVDF were coated with synthetic eumelanin from the tyrosinase-catalyzed polymerization of L-dopa, and with melanin extracted from human hair. Lead (Pb2+) binding

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22

MacIntyre, C. Raina. "Reevaluating the Risk of Smallpox Reemergence." Military Medicine 185, no. 7-8 (2020): e952-e957. http://dx.doi.org/10.1093/milmed/usaa084.

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Abstract Introduction Smallpox, caused by variola virus, was eradicated in 1980, but remains a category A bioterrorism agent. A decade ago, smallpox ranked second after anthrax in a multifactorial risk priority scoring analysis of category A bioterrorism agents. However, advances in genetic engineering and synthetic biology, including published methods for synthesizing an Orthopoxvirus, require the assumptions of this scoring for smallpox and other category A agents to be reviewed. Materials and Methods The risk priority framework was reviewed and revised to account for the capability for crea

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23

Li, Jing, Qing-Qing Zhi, Jie Zhang, et al. "Synthetic antimicrobial agents inhibit aflatoxin production." Brazilian Journal of Microbiology 52, no. 2 (2021): 821–35. http://dx.doi.org/10.1007/s42770-021-00423-4.

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Anwar, Ayaz, Ruqaiyyah Siddiqui, Abdul Hameed, Muhammad R. Shah, and Naveed A. Khan. "Synthetic Dihydropyridines as Novel Antiacanthamoebic Agents." Medicinal Chemistry 16, no. 7 (2020): 841–47. http://dx.doi.org/10.2174/1573406415666190722113412.

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Background: Acanthamoeba is an opportunistic pathogen widely spread in the environment. Acanthamoeba causes excruciating keratitis which can lead to blindness. The lack of effective drugs and its ability to form highly resistant cyst are one of the foremost limitations against successful prognosis. Current treatment involves mixture of drugs at high doses but still recurrence of infection can occur due to ineffectiveness of drugs against the cyst form. Pyridine and its natural and synthetic derivatives are potential chemotherapeutic agents due to their diverse biological activities. Objective:

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Stefanovic, Olgica, Ivana Radojevic, and Ljiljana Comic. "Synthetic cinnamates as potential antimicrobial agents." Chemical Industry 69, no. 1 (2015): 37–42. http://dx.doi.org/10.2298/hemind130928014s.

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This study deals with synthesis of methyl cinnamate, butyl cinnamate, and p-methoxy methyl cinnamate and testing of their in vitro antimicrobial activity. Antimicrobial activity was examined towards 29 microorganisms using microdilution method. It is shown that antimicrobial activity of methyl cinnamate and p-methoxy methyl cinnamate was better than that of butyl cinnamate. Sarcina lutea, Bacillus subtilis ATCC 6633, B. subtilis and B. subtilis IP 5832 (probiotic) were the most sensitive bacteria. It is established that p-methoxy methyl cinnamate can be a new, potential anti-Staphylococcus aur

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DODDS, E. C. "The significance of synthetic oestrogenic agents." Acta Medica Scandinavica 95, S90 (2009): 141–45. http://dx.doi.org/10.1111/j.0954-6820.1938.tb09025.x.

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Zhao, J., M. A. Johnson, R. Fisher, N. A. D. Burke, and H. D. H. Stöver. "Synthetic Polyampholytes as Macromolecular Cryoprotective Agents." Langmuir 35, no. 5 (2018): 1807–17. http://dx.doi.org/10.1021/acs.langmuir.8b01602.

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Curran, Dennis P. "Synthetic approaches to homocamptothecin antitumor agents." Comptes Rendus Chimie 11, no. 11-12 (2008): 1574–83. http://dx.doi.org/10.1016/j.crci.2008.10.002.

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Dallavalle, Sabrina, and Franco Zunino. "Synthetic retinoids as potential antitumour agents." Expert Opinion on Therapeutic Patents 15, no. 11 (2005): 1625–35. http://dx.doi.org/10.1517/13543776.15.11.1625.

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Clarke, W., and L. W. C. Miles. "Synthetic Thickening Agents for Textile Printing." Review of Progress in Coloration and Related Topics 13, no. 1 (2008): 27–31. http://dx.doi.org/10.1111/j.1478-4408.1983.tb03723.x.

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Arnon, Ruth, and Raphael Levi. "Synthetic Recombinant Vaccines against Viral Agents." International Archives of Allergy and Immunology 108, no. 4 (1995): 321–26. http://dx.doi.org/10.1159/000237175.

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Zoloev, G. K., V. D. Slepushkin, E. S. Argintaev, I. A. Prum, and G. E. Sokolovich. "Synthetic enkephalin analogs as antiatherogenic agents." Bulletin of Experimental Biology and Medicine 108, no. 4 (1989): 1466–69. http://dx.doi.org/10.1007/bf00841736.

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Thomsen, Ragnar, Line M. Nielsen, Niels B. Holm, Henrik B. Rasmussen, and Kristian Linnet. "Synthetic cannabimimetic agents metabolized by carboxylesterases." Drug Testing and Analysis 7, no. 7 (2014): 565–76. http://dx.doi.org/10.1002/dta.1731.

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Antoniolli, Giorgio, Keli Lima, João Agostinho Machado-Neto, Carmen Silvia Passos Lima, and Fernando Coelho. "SYNTHETIC QUINAZOLINONES AS NEW ANTILEUKEMIC AGENTS." Hematology, Transfusion and Cell Therapy 47 (May 2025): 103763. https://doi.org/10.1016/j.htct.2025.103763.

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AR, Nannar. "Review on Pharmaceutical Gelling Agents." Physical Science & Biophysics Journal 8, no. 1 (2024): 1–11. http://dx.doi.org/10.23880/psbj-16000266.

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Topical gels are semisolid solutions with a liquid phase contained inside a three-dimensional polymeric matrix composed of gum, which can be synthetic or natural and has a high degree of cross-linking, either chemically or physically. Topical gels' behaviour in the midst of liquid and solid components makes them a great option for a variety of applications. Topical gels have garnered a lot of attention recently since scientists in industry, research and development, education, drug control administration, and professional domains are interested in this issue. The purpose of this page is to go

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Vishnuvardhini R and Priya R Iyer. "A review on antifungal agents against Candida albicans and Aspergillus niger." International Journal of Biological and Pharmaceutical Sciences Archive 2, no. 1 (2021): 042–54. http://dx.doi.org/10.53771/ijbpsa.2021.2.1.0061.

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Candidiasis is the fungal infection caused by Candida albicans. It causes different type of candidiasis infections in the blood, heart, eyes, brain, bones also other parts of our body. Different types of candidiasis are vaginal candidiasis, pulmonary candidiasis, oral candidiasis. It may be acute or chronic. It can be cured by using natural compounds or synthetic compounds or semisynthetic compounds. Apergillosis is the fungal infections in human caused by Aspergillus niger. Aspergillosis infections are classified into allergic pulmonary sinusitis, cutaneous aspergillosis, invasive aspergillos

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Salotra, Riddhi, and Divya Utreja. "A Comprehensive Appraisal of Chalcones and Their Heterocyclic Analogs as Antimicrobial Agents." Current Organic Chemistry 24, no. 23 (2020): 2755–81. http://dx.doi.org/10.2174/1385272824999200922090524.

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Owing to the growing demand for compelling antimicrobial agents, chalcones and their heterocyclic derivatives have engrossed prodigious attention of medicinal chemists as an effective clinical template for the synthesis of such agents on account of their structural diversity and molecular flexibility. Chalcones are considered as a fortunate scaffold in the field of both synthetic as well as natural product chemistry. They are reflected as a remarkable section of logically occurring pharmacophores that possess a comprehensive scale of biological activities, such as anti-cancer, anti-malarial, a

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Tella, Toluwani, Carolina Pohl, and Kovalchuk Igor. "A review on diabetes mellitus: complications, synthetic anti-diabetic agents and herbal treatment." F1000Research 13 (February 19, 2024): 124. http://dx.doi.org/10.12688/f1000research.141015.1.

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Background Diabetes mellitus is a metabolic disorder with multiple symptoms and complications. The management of these conditions involve the use of synthetic anti-diabetic agents, natural products and medicinal plants. Synthetic anti-diabetic agents are associated with side effects whereas medicinal plants have minimal side effects and are less expensive. The aim of this work is to highlight various (i) complications associated with diabetes (ii) synthetic anti-diabetic agents used for treatment (iii) medicinal plants as anti-diabetic agents. Methods Electronic databases such as Web of Scienc

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Rubab, Laila, Sumbal Afroz, Sajjad Ahmad, et al. "An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents." Molecules 27, no. 5 (2022): 1604. http://dx.doi.org/10.3390/molecules27051604.

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Coumarin is an important six-membered aromatic heterocyclic pharmacophore, widely distributed in natural products and synthetic molecules. The versatile and unique features of coumarin nucleus, in combination with privileged sulfonamide moiety, have enhanced the broad spectrum of biological activities. The research and development of coumarin, sulfonamide-based pharmacology, and medicinal chemistry have become active topics, and attracted the attention of medicinal chemists, pharmacists, and synthetic chemists. Coumarin sulfonamide compounds and analogs as clinical drugs have been used to cure

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Madhulika, G. S. S. V., and B. Ramya Kuber. "A review on natural and synthetic polymers employed in the formulation of oral disintegrating tablets." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 652–58. http://dx.doi.org/10.22270/jddt.v9i2-s.2553.

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The oral route is the most popular route of administration for numerous drugs because it is considered as a safest, most preferred and less economical. Disintegrating agents are the substances that disperse or dissolve within a matter of seconds. This disintegrating mechanism helps in dysphagia, pediatric and geriatric patients. Synthetic disintegrating agents are available as a highly economical and less effective when compared to natural disintegrating agents. Therefore natural disintegrants serve as the best alternative to overcome the problems of these synthetic substances. Due to their nu

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Wilson, Rebecca M., and Samuel J. Danishefsky. "Promising agents at the interface of biology and oncology derived through chemical synthesis." Pure and Applied Chemistry 79, no. 12 (2007): 2189–216. http://dx.doi.org/10.1351/pac200779122189.

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This account traces the development of our synthetic glycopeptide- and glycoprotein-based research program over the past decade. We recount the syntheses of a number of biologically relevant, natural product-inspired glycopeptide constructs, including those associated with prostate specific antigen (PSA) and with the gp120 surface envelope protein of HIV. We also describe our progress toward the synthesis of the multiply glycosylated protein, erythropoietin (EPO). Particular emphasis is placed on the development of enabling methodologies which allow for the ligation of complex glycopeptide fra

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Ricci, Alfredo, Alessandro Degl'Innocenti, Stefano Chimichi, Mariella Fiorenza, and Gabriele Rossini. "Heteroacylsilanes: synthesis and synthetic potentialities of new nucleophilic acylation agents." Journal of Organic Chemistry 50, no. 1 (1985): 130–33. http://dx.doi.org/10.1021/jo00201a029.

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Melen, Rebecca, Yashar Soltani, and Lewis Wilkins. "A Comparative Assessment of Modern Cyclization Methods of Substituted Alkynyl Esters, Ethers, and Acids." Synlett 29, no. 01 (2017): 01–07. http://dx.doi.org/10.1055/s-0036-1591862.

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Naturally occurring heterocycles such as pyrones, dihydropyrones, and isocoumarins have proven to be highly active biological agents with a vast plethora of applications. Therefore, their synthesis has attracted mentionable notice in recent decades. Of particular synthetic use is the cyclization of substituted alkynyl esters. More recently, main group compounds have been studied to affect this synthetic pathway giving access to a large family of heterocyclic derivatives.

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Sanjay, P. Mote, and A. Bulakhe Bhau. "An Active Ingredient In Drugs Synthesis: Derivetives Of Phenyl Carbamide And Carbamate." International Journal of Advance and Applied Research S6, no. 18 (2025): 315–18. https://doi.org/10.5281/zenodo.15259706.

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<em>Phenyl carbamides and carbamates represent pivotal scaffolds in medicinal chemistry, serving as core structures in numerous pharmacologically active compounds. Their unique chemical properties facilitate diverse synthetic routes, leading to the development of various therapeutic agents. This paper delves into the significance of phenyl carbamides and carbamates in drug synthesis, exploring their chemical characteristics, synthetic methodologies, and applications in medicinal chemistry. Emphasis is placed on recent advancements and the role of these compounds in the efficient synthesis of b

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Sarangi, P. K. N., J. Sahoo, B. D. Swain, S. K. Paidesetty, and G. P. Mohanta. "THIAZOLES AS POTENT ANTICANCER AGENTS: A REVIEW." INDIAN DRUGS 53, no. 11 (2016): 5–11. http://dx.doi.org/10.53879/id.53.11.10755.

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The chemistry of heterocyclic compounds plays a crucial role in the synthesis of medicinals. This review focuses on the use of the thiazole nucleus for the synthesis of newer drug molecules through rational drug discovery. Here the synthetic feasibility, biochemical compatibility and the therapeutic utility of the thiazole derivatives is discussed briefly. Recently, it was observed that many chemotherapeutic agents have a thiazole nucleus. Hence, this article highlights the profound anti-cancer activities of some major thiazole bearing drug molecules with their important target sites. Along wi

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Mittal, Rajinder Pal, Abhilash Rana, and Vikas Jaitak. "Essential Oils: An Impending Substitute of Synthetic Antimicrobial Agents to Overcome Antimicrobial Resistance." Current Drug Targets 20, no. 6 (2019): 605–24. http://dx.doi.org/10.2174/1389450119666181031122917.

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Antimicrobial resistance (AMR) is an emerging problem in the world that has a significant impact on our society. AMR made conventional drugs futile against microorganisms and diseases untreatable. Plant-derived medicines are considered to be safe alternatives as compared to synthetic drugs. Active ingredients and the mixtures of these natural medicines have been used for centuries, due to their easy availability, low cost, and negligible side effects. Essential oils (EOs) are the secondary metabolites that are produced by aromatic plants to protect them from microorganisms. However, these EOs

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Liu, Andrew H., Julia Hootman, Dongmei Li, and Zidian Xie. "Public perceptions of synthetic cooling agents in electronic cigarettes on Twitter." PLOS ONE 19, no. 3 (2024): e0292412. http://dx.doi.org/10.1371/journal.pone.0292412.

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Amid a potential menthol ban, electronic cigarette (e-cigarette) companies are incorporating synthetic cooling agents like WS-3 and WS-23 to replicate menthol/mint sensations. This study examines public views on synthetic cooling agents in e-cigarettes via Twitter data. From May 2021 to March 2023, we used Twitter Streaming Application Programming Interface (API), to collect tweets related to synthetic cooling agents with keywords such as ‘WS-23,’ ’ice,’ and ’frozen.’ The deep learning RoBERTa (Robustly Optimized BERT-Pretraining Approach) model that can be optimized for contextual language un

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Sirisha, N., and R. Raghunathan. "Regioselective Synthesis of Dispiro Pyrrolizidines as Potent Antimicrobial Agents for Human Pathogens." ISRN Medicinal Chemistry 2013 (September 10, 2013): 1–8. http://dx.doi.org/10.1155/2013/492604.

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Synthesis of a series of novel dispiro pyrrolizidines has been accomplished by 1,3-dipolar cycloaddition reaction of azomethine ylide generated from secondary amino acids and diketones with bischalcones. These compounds were evaluated for their antibacterial activity. Most of the synthetic compounds exhibited good antibacterial activity against microorganisms.

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Déléris, Gérard. "Use of Organosilicon Compounds towards the Rational Design of Antiparasitic and Antiviral Drugs." Metal-Based Drugs 2, no. 3 (1995): 143–51. http://dx.doi.org/10.1155/mbd.1995.143.

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One of the major problems met for the conception of antiviral or antiparasitic drugs is to reach a high level of selectivity towards the pathogenic agent versus the host. We shall describe two synthetic approaches where main group organometallics have been used towards this goal. A series of nucleoside sila-analogues was synthesized as potential therapeutic agents designed to inhibit HIV Reverse Transcriptase. In a second approach novel organosilicon derivatives have been synthesized as mimics of antisense oligonucleotides.Infectious agents, namely viruses or parasites, more or less use cellul

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Wei, Tu, Wang Ha, and Peng Guang. "Synthetic lethality as a promising approach for targeted cancer prevention." Biohelikon 2, no. 1 (2014): 1–2. https://doi.org/10.5281/zenodo.814329.

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Carcinogenesis is recognized as a multistep process. It occurs over a relative long span of time, which offers intervention opportunities for cancer prevention. Using drugs to prevent cancer rather than treat cancer is the major research goal in the field of ‘chemoprevention’. Tremendous research efforts have been devoted toward using natural, synthetic or biological agents to prevent, suppress or delay the initiation and or the progression of premalignant cells to cancer. However a big challenge for effective cancer prevention is to identify chemoprevention agents with demonstrable efficacy a

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